ZMB Member Sebastian Bauer

ZMB Member
Sebastian Bauer

Next ZMB-Member
Sebastian Bauer
© UKE/S.Bauer

Prof. Dr. Sebastian Bauer

Group

Translational Sarcoma Research

West German Cancer Center (WTZ)
University Hospital Essen
Hufelandstr. 55
45147 Essen

Research Overview

  1. Analysis of oncogenetic signalling pathways in soft-tissue sarcoma (esp. GIST)
  2. Evaluation of purposive, small molecular inhibitors of tyrosine kinases in soft-tissue sarcoma
  3. Development of soft-tissue sarcoma models (cell lines and Xenografts)
  4. Evaluation of preclinical diagnostic techniques/methods (in vitro/in vivo) for GIST and other soft-tissue sarcoma
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Selected Publications

    Journal articles

  • Teuber, A.; Schulz, T.; Fletcher, B.S.; Gontla, R.; Mühlenberg, Thomas; Zischinsky, M.-L.; Niggenaber, J.; Weisner, J.; Kleinbölting, S.B.; Lategahn, J.; Sievers, S.; Müller, M.P.; Bauer, Sebastian; Rauh, D.
    Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA
    In: Nature Communications, Vol. 15, 2024, Nr. 1, 63
    DOI (Open Access)
  • Heinrich, Michael C.; Zhang, Xinhua; Jones, Robin L.; George, Suzanne; Serrano, César; Deng, Yanhong; Bauer, Sebastian; Cai, Shirong; Wu, Xin; Zhou, Yongjian; Tao, Kaixiong; Zheng, Zhichao; Zhang, Jun; Cui, Yuehong; Cao, Hui; Wang, Meining; Hu, Jin; Yang, Jason; Li, Jian; Shen, Lin
    Clinical Benefit of Avapritinib in KIT-Mutant Gastrointestinal Stromal Tumors : A Post Hoc Analysis of the Phase I NAVIGATOR and Phase I/II CS3007-001 Studies
    In: Clinical Cancer Research, Vol. 30, 2024, Nr. 4, pp. 719 – 728
    DOI
  • Tretter, Celina; de Andrade Krätzig, Niklas; Pecoraro, Matteo; Lange, Sebastian; Seifert, Philipp; von Frankenberg, Clara; Untch, Johannes; Zuleger, Gabriela; Wilhelm, Mathias; Zolg, Daniel P.; Dreyer, Florian S.; Bräunlein, Eva; Engleitner, Thomas; Uhrig, Sebastian; Boxberg, Melanie; Steiger, Katja; Slotta-Huspenina, Julia; Ochsenreither, Sebastian; von Bubnoff, Nikolas; Bauer, Sebastian; Boerries, Melanie; Jost, Philipp J.; Schenck, Kristina; Dresing, Iska; Bassermann, Florian; Friess, Helmut; Reim, Daniel; Grützmann, Konrad; Pfütze, Katrin; Klink, Barbara; Schröck, Evelin; Haller, Bernhard; Kuster, Bernhard; Mann, Matthias; Weichert, Wilko; Fröhling, Stefan; Rad, Roland; Hiltensperger, Michael; Krackhardt, Angela M.
    Correction to: Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification
    In: Nature Communications, Vol. 15, 2024, Nr. 1, 2364
    DOI (Open Access)
  • Heinrich, Michael C.; Jones, Robin L.; George, Suzanne; Gelderblom, Hans; Schöffski, Patrick; von Mehren, Margaret; Zalcberg, John R.; Kang, Yoon-Koo; Razak, Albiruni Abdul; Trent, Jonathan; Attia, Steven; Le Cesne, Axel; Siontis, Brittany L.; Goldstein, David; Boye, Kjetil; Sanchez, Cesar; Steeghs, Neeltje; Rutkowski, Piotr; Druta, Mihaela; Serrano, César; Somaiah, Neeta; Chi, Ping; Reichmann, William; Sprott, Kam; Achour, Haroun; Sherman, Matthew L.; Ruiz-Soto, Rodrigo; Blay, Jean-Yves; Bauer, Sebastian
    Ripretinib versus sunitinib in gastrointestinal stromal tumor : ctDNA biomarker analysis of the phase 3 INTRIGUE trial
    In: Nature Medicine, Vol. 30, 2024, Nr. 2, pp. 498 – 506
    DOI (Open Access)
  • Joensuu, Heikki; Wardelmann, Eva; Eriksson, Mikael; Reichardt, Annette; Hall, Kirsten Sundby; Schütte, Jochen; Cameron, Silke; Hohenberger, Peter; Sihto, Harri; Jost, Philipp J.; Lindner, Lars H.; Bauer, Sebastian; Nilsson, Bengt; Kallio, Raija; Pesonen, Tommi; Reichardt, Peter
    KIT and PDGFRA Mutations and Survival of Gastrointestinal Stromal Tumor Patients Treated with Adjuvant Imatinib in a Randomized Trial
    In: Clinical Cancer Research, Vol. 29, 2023, Nr. 17, pp. 3313 – 3319
    DOI (Open Access)
  • Tretter, Celina; de Andrade Krätzig, Niklas; Pecoraro, Matteo; Lange, Sebastian; Seifert, Philipp; von Frankenberg, Clara; Untch, Johannes; Zuleger, Gabriela; Wilhelm, Mathias; Zolg, Daniel P.; Dreyer, Florian S.; Bräunlein, Eva; Engleitner, Thomas; Uhrig, Sebastian; Boxberg, Melanie; Steiger, Katja; Slotta-Huspenina, Julia; Ochsenreither, Sebastian; von Bubnoff, Nikolas; Bauer, Sebastian; Boerries, Melanie; Jost, Philipp J.; Schenck, Kristina; Dresing, Iska; Bassermann, Florian; Friess, Helmut; Reim, Daniel; Grützmann, Konrad; Pfütze, Katrin; Klink, Barbara; Schröck, Evelin; Haller, Bernhard; Kuster, Bernhard; Mann, Matthias; Weichert, Wilko; Fröhling, Stefan; Rad, Roland; Hiltensperger, Michael; Krackhardt, Angela M.
    Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification
    In: Nature Communications, Vol. 14, 2023, Nr. 1, 4632
    DOI (Open Access)
  • Koch, Raphael; Haveman, Lianne; Ladenstein, Ruth; Brichard, Benedicte; Jürgens, Heribert; Cyprova, Sona; van den Berg, Henk; Hassenpflug, Wolf; Raciborska, Anna; Ek, Torben; Baumhoer, Daniel; Egerer, Gerlinde; Kager, Leo; Renard, Marleen; Hauser, Peter; Burdach, Stefan; Bovee, Judith V M G; Hong, Angela M.; Reichardt, Peter; Kruseova, Jarmila; Streitbürger, Arne; Kühne, Thomas; Kessler, Torsten; Bernkopf, Marie; Butterfaß-Bahloul, Trude; Dhooge, Catharina; Bauer, Sebastian; Kiss, János; Paulussen, Michael; Bonar, Fiona; Ranft, Andreas; Timmermann, Beate; Rascon, Jelena; Vieth, Volker; Kanerva, Jukka; Faldum, Andreas; Hartmann, Wolfgang; Hjorth, Lars; Bhadri, Vivek A.; Metzler, Markus; Gelderblom, Hans; Dirksen, Uta
    Zoledronic Acid Add-on Therapy for Standard-Risk Ewing Sarcoma Patients in the Ewing 2008R1 Trial
    In: Clinical Cancer Research, Vol. 29, 2023, Nr. 24, pp. 5057 – 5068
    DOI
  • Vincenzi, Bruno; Napolitano, Andrea; Fiocco, Marta; Mir, Olivier; Rutkowski, Piotr; Blay, Jean-Yves; Reichardt, Peter; Joensuu, Heikki; Fumagalli, Elena; Gennatas, Spyridon; Hindi, Nadia; Nannini, Margherita; Ceruso, Mariella Spalato; Italiano, Antoine; Grignani, Giovanni; Brunello, Antonella; Gasperoni, Silvia; De Pas, Tommaso; Badalamenti, Giuseppe; Pantaleo, Maria A.; Van Houdt, Winan J.; IJzerman, Nikki S.; Steeghs, Neeltje; Gelderblom, Hans; Desar, Ingrid M.E.; Falkenhorst, Johanna; Silletta, Marianna; Sbaraglia, Marta; Tonini, Giuseppe; Martin-Brot, Javier; Hohenberger, Peter; Le Cesne, Axel; Jones, Robin L.; Dei Tos, Angelo P.; Gronchi, Alessandro; Bauer, Sebastian; Casali, Paolo G.
    Adjuvant Imatinib in Patients with GIST Harboring Exon 9 KIT Mutations : Results from a Multi-institutional European Retrospective Study
    In: Clinical Cancer Research, Vol. 28, 2022, Nr. 8, pp. 1672 – 1679
    DOI (Open Access)
  • Abdul Razak, Albiruni R.; Bauer, Sebastian; Suarez, Cristina; Lin, Chia-Chi; Quek, Richard; Hütter-Krönke, Marie Luise; Cubedo, Ricardo; Ferretti, Stephane; Guerreiro, Nelson; Jullion, Astrid; Orlando, Elena J.; Clementi, Giorgia; Dejmek, Janna Sand; Halilovic, Ensar; Fabre, Claire; Blay, Jean-Yves; Italiano, Antoine; Sand Dejmek, Janna
    Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma : Results from a Proof-of-Concept, Phase Ib Study
    In: Clinical Cancer Research, Vol. 28, 2022, Nr. 6, pp. 1087 – 1097
    DOI (Open Access)
  • Stein, Eytan M.; DeAngelo, Daniel J.; Chromik, Jörg; Chatterjee, Manik; Bauer, Sebastian; Lin, Chia-Chi; Suarez, Cristina; de Vos, Filip; Steeghs, Neeltje; Cassier, Philippe A.; Tai, David; Kiladjian, Jean-Jacques; Yamamoto, Noboru; Mous, Rogier; Esteve, Jordi; Minami, Hironobu; Ferretti, Stephane; Guerreiro, Nelson; Meille, Christophe; Radhakrishnan, Rajkumar; Pereira, Bernard; Mariconti, Luisa; Halilovic, Ensar; Fabre, Claire; Carpio, Cecilia; Cassier, Phillippe A.
    Results from a First-in-Human Phase I Study of Siremadlin (HDM201) in Patients with Advanced Wild-Type TP53 Solid Tumors and Acute Leukemia
    In: Clinical Cancer Research, Vol. 28, 2022, Nr. 5, pp. 870 – 881
    DOI (Open Access)
  • Fendler, Wolfgang P.; Pabst, Kim M.; Kessler, Lukas; Fragoso Costa, Pedro; Ferdinandus, Justin; Weber, Manuel; Lippert, Maria; Lückerath, Katharina; Umutlu, Lale; Kostbade, Karina; Mavroeidi, Ilektra A.; Schuler, Martin; Ahrens, Marit; Rischpler, Christoph; Bauer, Sebastian; Herrmann, Ken; Siveke, Jens T.; Hamacher, Rainer
    Safety and Efficacy of 90Y-FAPI-46 Radioligand Therapy in Patients with Advanced Sarcoma and Other Cancer Entities
    In: Clinical Cancer Research, Vol. 28, 2022, Nr. 19, pp. 4346 – 4353
    DOI (Open Access)
  • Bauer, Sebastian; Heinrich, Michael C.; George, Suzanne; Zalcberg, John R.; Serrano, César; Gelderblom, Hans; Jones, Robin L.; Attia, Steven; D'Amato, Gina; Chi, Ping; Reichardt, Peter; Meade, Julie; Su, Ying; Ruiz-Soto, Rodrigo; Blay, Jean-Yves; von Mehren, Margaret; Schöffski, Patrick
    Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study
    In: Clinical Cancer Research, Vol. 27, 2021, Nr. 23, pp. 6333 – 6342
    DOI, Online Full Text (Open Access)
  • Gröschel, Stefan; Hübschmann, Daniel; Raimondi, Francesco; Horak, Peter; Warsow, Gregor; Fröhlich, Martina; Klink, Barbara; Gieldon, Laura; Hutter, Barbara; Kleinheinz, Kortine; Bonekamp, David; Marschal, Oliver; Chudasama, Priya; Mika, Jagoda; Groth, Marie; Uhrig, Sebastian; Krämer, Stephen; Heining, Christoph; Heilig, Christoph E.; Richter, Daniela; Reisinger, Eva; Pfütze, Katrin; Eils, Roland; Wolf, Stephan; Kalle, Christof von; Brandts, Christian; Scholl, Claudia; Weichert, Wilko; Richter, Stephan; Bauer, Sebastian; Penzel, Roland; Schröck, Evelin; Stenzinger, Albrecht; Schlenk, Richard F.; Brors, Benedikt; Russell, Robert B.; Glimm, Hanno; Schlesner, Matthias; Fröhling, Stefan
    Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
    In: Nature Communications, Vol. 10, 2019, Nr. 1, pp. 1635
    DOI (Open Access)
  • Chudasama, Priya; Mughal, Sadaf S.; Schröck, Evelin; Glimm, Hanno; Kleinheinz, Kortine; Klink, Barbara; Brors, Benedikt; Hlevnjak, Mario; Gröschel, Stefan; Wolf, Stephan; Omlor, Georg; Ernst, Aurélie; Ulrich, Alexis; Deeg, Katharina I.; Mechtersheimer, Gunhild; Schimmack, Simon; Eils, Roland; Egerer, Gerlinde; Kasper, Bernd; Wong, Siao-Han; von Kalle, Christof; Hohenberger, Peter; Lehner, Burkhard; Rippe, Karsten; Chung, Inn; Bauer, Sebastian; Scholl, Claudia; Sieverling, Lina; Sanders, Mathijs A.; Hübschmann, Daniel; Heilig, Christoph E.; Hutter, Barbara; Renner, Marcus; Weichert, Wilko; Stenzinger, Albrecht; Schlesner, Matthias; Hoogenboezem, Remco M.; Kopp, Hans-Georg; Rabe, Sophie; Zapatka, Marc; Fröhling, Stefan
    Integrative genomic and transcriptomic analysis of leiomyosarcoma
    In: Nature Communications, Vol. 9, 2018, Nr. 1, pp. 144
    DOI (Open Access)
  • Schaefer, Inga-Marie; Wang, Yuexiang; Liang, Cher-Wei; Bahri, Nacef; Quattrone, Anna; Doyle, Leona; Marinõ-Enríquez, Adrian; Lauria, Alexandra; Zhu, Meijun; Debiec-Rychter, Maria; Grunewald, Susanne; Hechtman, Jaclyn F.; Dufresne, Armelle; Antonescu, Cristina R.; Beadling, Carol; Sicinska, Ewa T.; Van De Rijn, Matt; Demetri, George D.; Ladanyi, Marc; Corless, Christopher L.; Heinrich, Michael C.; Raut, Chandrajit P.; Bauer, Sebastian; Fletcher, Jonathan A.
    MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation
    In: Nature Communications, Vol. 8, 2017, 14674
    DOI (Open Access)
  • Kim, Won Kyu; Yun, SeongJu; Park, Cheol Keun; Bauer, Sebastian; Kim, Jiyoon; Lee, Min Goo; Kim, Hoguen
    Sustained mutant KIT activation in the Golgi complex is mediated by PKC-θ in gastrointestinal stromal tumors
    In: Clinical Cancer Research, Vol. 23, 2017, Nr. 3, pp. 845 – 856
    DOI
  • Garner, Andrew P.; Gozgit, Joseph M.; Anjum, Rana; Vodala, Sadanand; Schrock, Alexa; Zhou, Tianjun; Serrano, César; Eilers, Grant; Zhu, Meijun; Ketzer, Julia; Wardwell, Scott D.; Ning, Yaoyu; Song, Youngchul; Kohlmann, Anna; Wang, Frank; Clackson, Tim P.; Heinrich, Michael C.; Fletcher, Jonathan A.; Bauer, Sebastian; Rivera, Víctor M.
    Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients
    In: Clinical Cancer Research, Vol. 20, 2014, Nr. 22, pp. 5745 – 5755
    DOI
  • Simon, Susanne; Grabellus, Florian; Ferrera, Loretta; Galietta, Luis; Schwindenhammer, Benjamin; Mühlenberg, Thomas; Täger, Georg; Eilers, Grant; Treckmann, Jürgen-Walter; Breitenbücher, Frank; Schuler, Martin; Taguchi, Takahiro; Fletcher, Jonathan A.; Bauer, Sebastian
    DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
    In: Cancer Research, Vol. 73, 2013, Nr. 12, pp. 3661 – 3670
    DOI
  • Demetri, G. D.; Jeffers, M.; Reichardt, P.; Kang, Y. K.; Blay, J. Y.; Rutkowski, P.; Gelderblom, H.; Hohenberger, P.; Leahy, M.; von Mehren, M.; Joensuu, H.; Badalamenti, G.; Blackstein, M.; Le Cesne, A.; Schoffski, P.; Maki, R. G.; Bauer, Sebastian; Nguyen, B. B.; Xu, J. M.; Nishida, T.; Chung, J.; Lathia, C. D.; Kappeler, C.; Kuss, I.; Laurent, D.; Casali, P. G.
    Detection of oncogenic kinase mutations in circulating plasma DNA and correlation with clinical benefit in the phase III GRID study of regorafenib vs placebo in TKI-refractory metastatic GIST
    In: Cancer Research, Vol. 73, 2013, Nr. Suppl. 8
    DOI
  • Bauer, Sebastian; Parry, Joshua A.; Mühlenberg, Thomas; Brown, Matthew F.; Seneviratne, Danushka; Chatterjee, Payel; Chin, Anna; Rubin, Brian P.; Kuan, Shih-Fan; Fletcher, Jonathan A.; Duensing, Stefan; Duensing, Anette
    Proapoptotic activity of bortezomib in gastrointestinal stromal tumor cells
    In: Cancer Research, Vol. 70, 2010, Nr. 1, pp. 150 – 159
    DOI
  • Mühlenberg, Thomas; Zhang, Yixiang; Wagner, Andrew J.; Grabellus, Florian; Bradner, James; Täger, Georg; Lang, Hauke; Taguchi, Takahiro; Schuler, Martin; Fletcher, Jonathan A.; Bauer, Sebastian
    Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors
    In: Cancer Research, Vol. 69, 2009, Nr. 17, pp. 6941 – 6950
    DOI (Open Access)
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