ZMB Member Sebastian Bauer

ZMB Member
Sebastian Bauer

Next ZMB-Member
Sebastian Bauer
© UKE/S.Bauer

Prof. Dr. Sebastian Bauer

West German Cancer Center (WTZ)
University Hospital Essen
Hufelandstr. 55
45147 Essen

Research Overview

  1. Analysis of oncogenetic signalling pathways in soft-tissue sarcoma (esp. GIST)
  2. Evaluation of purposive, small molecular inhibitors of tyrosine kinases in soft-tissue sarcoma
  3. Development of soft-tissue sarcoma models (cell lines and Xenografts)
  4. Evaluation of preclinical diagnostic techniques/methods (in vitro/in vivo) for GIST and other soft-tissue sarcoma
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Selected Publications

    Journal articles

  • Grunewald, Susanne; Klug, Lillian R.; Mühlenberg, Thomas; Lategahn, Jonas; Falkenhorst, Johanna; Town, Ajia; Ehrt, Christiane; Wardelmann, Eva; Hartmann, Wolfgang; Schildhaus, Hans-Ulrich; Treckmann, Jürgen Walter; Fletcher, Jonathan A.; Jung, Sascha; Czodrowski, Paul; Miller, Stephen; Schmidt-Kittler, Oleg; Rauh, Daniel; Heinrich, Michael C.; Bauer, Sebastian
    Resistance to avapritinib in pdgfra-driven gist is caused by secondary mutations in the pdgfra kinase domain
    In: Cancer Discovery Vol. 11 (2021) Nr. 1, pp. 108 - 125
    ISSN: 2159-8290; 2159-8274
  • Heinrich, Michael C.; Jones, Robin L.; von Mehren, Margaret; Schöffski, Patrick; Serrano, César; Kang, Yoon-Koo; Cassier, Philippe A.; Mir, Olivier; Eskens, Ferry; Tap, William D.; Rutkowski, Piotr; Chawla, Sant P.; Trent, Jonathan; Tugnait, Meera; Evans, Erica K.; Lauz, Tamieka; Zhou, Teresa; Roche, Maria; Wolf, Beni B.; Bauer, Sebastian; George, Suzanne
    Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR) : A multicentre, open-label, phase 1 trial
    In: The Lancet Oncology Vol. 21 (2020) Nr. 7, pp. 935 - 946
    ISSN: 1474-5488; 1470-2045
  • Heinrich, Michael C.; George, Suzanne; Zalcberg, John Raymond; Bauer, Sebastian; Gelderblom, Hans; Schoffski, Patrick; Serrano, Cesar; Jones, Robin L.; Attia, Steven; D'Amato, Gina Z.; Chi, Ping; Reichardt, Peter; Becker, Claus C.; Meade, Julie Nicole; Ruiz-Soto, Rodrigo; von Mehren, Margaret; Blay, Jean-Yves
    Quality of life (QoL) and self-reported function with ripretinib in ≥4th-line therapy for patients with gastrointestinal stromal tumors (GIST) : Analyses from INVICTUS
    In: Journal of Clinical Oncology Vol. 38 (2020) Nr. 15_Suppl., pp. 11535
    ISSN: 0732-183X; 1527-7755
  • Grünwald, Viktor; Karch, Annika; Schuler, Markus; Schöffski, Patrick; Kopp, Hans-Georg; Bauer, Sebastian; Kasper, Bernd; Lindner, Lars H.; Chemnitz, Jens-Marcus; Crysandt, Martina; Stein, Alexander; Steffen, Björn; Richter, Stephan; Egerer, Gerlinde; Ivanyi, Philipp; Zimmermann, Silke; Liu, Xiaofei; Kunitz, Annegret
    Randomized Comparison of Pazopanib and Doxorubicin as First-Line Treatment in Patients with Metastatic Soft Tissue Sarcoma Age 60 Years or Older : Results of a German Intergroup Study
    In: Journal of Clinical Oncology Vol. 38 (2020) Nr. 30, pp. 3555 - 3564
    ISSN: 1527-7755; 0732-183X
  • Blay, Jean-Yves; Serrano, César; Heinrich, Michael C.; Zalcberg, John; Bauer, Sebastian; Gelderblom, Hans; Schöffski, Patrick; Jones, Robin L; Attia, Steven; D'Amato, Gina; Chi, Ping; Reichardt, Peter; Meade, Julie; Shi, Kelvin; Ruiz-Soto, Rodrigo; George, Suzanne; von Mehren, Margaret
    Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS) : a double-blind, randomised, placebo-controlled, phase 3 trial
    In: The Lancet Oncology Vol. 21 (2020) Nr. 7, pp. 923 - 934
    ISSN: 1474-5488; 1470-2045
  • George, Suzanne; Heinrich, Michael C.; Zalcberg, John Raymond; Bauer, Sebastian; Gelderblom, Hans; Schoffski, Patrick; Serrano, Cesar; Jones, Robin L.; Attia, Steven; D'Amato, Gina Z.; Chi, Ping; Reichardt, Peter; Lacouture, Mario E.; Cha, Elva; Meade, Julie Nicole; Ruiz-Soto, Rodrigo; Blay, Jean-Yves; von Mehren, Margaret
    Safety profile of ripretinib, including impact of alopecia, and Palmar-Plantar Erythrodysesthesia Syndrome (PPES) on patient-reported outcomes (PROs), in ≥ fourth-line advanced gastrointestinal stromal tumors (GIST) : Analyses from INVICTUS
    In: Journal of Clinical Oncology Vol. 38 (2020) Nr. 15_Suppl., pp. 11539
    ISSN: 0732-183X; 1527-7755
  • Gröschel, Stefan; Hübschmann, Daniel; Raimondi, Francesco; Horak, Peter; Warsow, Gregor; Fröhlich, Martina; Klink, Barbara; Gieldon, Laura; Hutter, Barbara; Kleinheinz, Kortine; Bonekamp, David; Marschal, Oliver; Chudasama, Priya; Mika, Jagoda; Groth, Marie; Uhrig, Sebastian; Krämer, Stephen; Heining, Christoph; Heilig, Christoph E.; Richter, Daniela; Reisinger, Eva; Pfütze, Katrin; Eils, Roland; Wolf, Stephan; Kalle, Christof von; Brandts, Christian; Scholl, Claudia; Weichert, Wilko; Richter, Stephan; Bauer, Sebastian; Penzel, Roland; Schröck, Evelin; Stenzinger, Albrecht; Schlenk, Richard F.; Brors, Benedikt; Russell, Robert B.; Glimm, Hanno; Schlesner, Matthias; Fröhling, Stefan
    Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1635
    ISSN: 2041-1723
  • Tap, William D.; Gelderblom, Hans; Palmerini, Emanuela; Desai, Jayesh; Bauer, Sebastian; Blay, Jean-Yves; Alcindor, Thierry; Ganjoo, Kristen; Martín-Broto, Javier; Ryan, Christopher W.; Thomas, David M.; Peterfy, Charles; Healey, John H.; Sande, Michiel van de; Gelhorn, Heather L.; Shuster, Dale E.; Wang, Qiang; Yver, Antoine; Hsu, Henry H.; Lin, Paul S.; Tong-Starksen, Sandra; Stacchiotti, Silvia; Wagner, Andrew J.
    Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN) : a randomised phase 3 trial
    In: The Lancet Vol. 394 (2019) Nr. 10197, pp. 478 - 487
    ISSN: 1474-547X; 0140-6736
  • Rutkowski, Piotr; Gelderblom, Hans; Strauss, Sandra J.; Bauer, Sebastian; van der Graaf, Winette TA; Hennig, Ivo M.; Reichardt, Peter; Schoffski, Patrick; Anthoney, Alan; Geoerger, Birgit; Blay, Jean-Yves; Leahy, Michael Gordon; Kasper, Bernd; Lindner, Lars H; Italiano, Antoine; Marreaud, Sandrine; Zakotnik, Branko; Aamdal, Steinar; Wozniak, Agnieszka; Stacchiotti, Silvia
    Activity and safety of crizotinib in patients with advanced, metastatic alveolar soft part sarcoma (ASPS) with rearrangement of TFE3 : European Organization for Research and Treatment of Cancer (EORTC) phase 2 trial 90101 CREATE
    In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 15 Suppl., pp. 11540
    ISSN: 0732-183X; 1527-7755
  • Schöffski, Patrick; Wozniak, A.; Kasper, B.; Aamdal, S.; Leahy, M.G.; Rutkowski, P.; Bauer, Sebastian; Gelderblom, H.; Italiano, A.; Lindner, L.H.; Hennig, I.; Strauss, S.; Zakotnik, B.; Anthoney, A.; Albiges, L.; Blay, J.-Y.; Reichardt, P.; Sufliarsky, J.; van der Graaf, W.T.A.; Debiec-Rychter, M.; Sciot, R.; Van Cann, T.; Marréaud, S.; Raveloarivahy, T.; Collette, S.; Stacchiotti, S.
    Activity and safety of crizotinib in patients with alveolar soft part sarcoma with rearrangement of TFE3 : European Organization for Research and Treatment of Cancer (EORTC) phase II trial 90101 'CREATE'
    In: Annals of Oncology Vol. 29 (2018) Nr. 3, pp. 758 - 765
    ISSN: 1569-8041; 0923-7534
  • Wyrwicz, Lucjan; Mehnert, Janice M.; Bauer, Sebastian; Gulley, James L.; Gravenor, Donald; Chin, Kevin M.; Nemunaitis, John J.; Lee, Keun-Wook; Patel, Manish R.; Bourgeois, Hugues Pierre; Keilholz, Ulrich; Kasturi, Vijay; Taylor, Matthew H.; von Heydebreck, Anja
    Avelumab in patients with previously treated metastatic melanoma : Phase 1b results from the JAVELIN Solid Tumor trial.
    In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 5 Suppl., pp. 191
    ISSN: 0732-183X; 1527-7755
  • Casali, P.G.; Bielack, S.; Abecassis, N.; Aro, H.T.; Bauer, Sebastian; Biagini, R.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Brennan, B.; Brodowicz, T.; Broto, J.M.; Brugières, L.; Buonadonna, A.; De Álava, E.; Dei Tos, A.P.; Del Muro, X.G.; Dileo, P.; Dhooge, C.; Eriksson, M.; Fagioli, F.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Ferrari, S.; Frezza, A.M.; Gaspar, N.; Gasperoni, S.; Gelderblom, H.; Gil, T.; Grignani, G.; Gronchi, A.; Haas, R.L.; Hassan, B.; Hecker-Nolting, S.; Hohenberger, P.; Issels, R.; Joensuu, H.; Jones, R.L.; Judson, I.; Jutte, P.; Kaal, S.; Kager, L.; Kasper, B.; Kopeckova, K.; Krákorová, D.A.; Ladenstein, R.; Le Cesne, A.; Lugowska, I.; Merimsky, O.; Montemurro, M.; Morland, B.; Pantaleo, M.A.; Piana, R.; Picci, P.; Piperno-Neumann, S.; Pousa, A.L.; Reichardt, P.; Robinson, M.H.; Rutkowski, P.; Safwat, A.A.; Schöffski, P.; Sleijfer, S.; Stacchiotti, S.; Strauss, S.J.; Sundby Hall, K.; Unk, M.; Van Coevorden, F.; Van Der Graaf, W.T.A.; Whelan, J.; Wardelmann, E.; Zaikova, O.; Blay, J.Y.
    Bone sarcomas : ESMO-PaedCan-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
    In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 4, pp. iv79 - iv95
    ISSN: 0923-7534
  • George, Suzanne; Bauer, Sebastian; Jones, Robin L.; Serrano, Christina S.; Mehren, Margaret M. von; Kang, Y.-K.; Schöffski, Patrick; Cassier, Philippe A.; Eskens, Ferry A.; Mir, Olivier; Tap, William D.; Chawla, Sant P.; Rutkowski, Piotr; Shi, H.; Schmidt-Kittler, Oleg; Mar, B.; Heinrich, Michael
    Correlation of ctDNA and response in patients (pts) with PDGFRα D842 GIST treated with avapritinib
    In: Annals of Oncology: official journal of the European Society for Medical Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii584
    ISSN: 0923-7534; 1569-8041
  • Bauer, Sebastian; Sufliarsky, Jozef; Schoffski, Patrick; Rutkowski, Piotr; Escudier, Bernard; Van Herpen, Carla M.L.-; Raveloarivahy, Tiana; Lia, Michela; Grünwald, Viktor; Anthoney, Alan; Albiges, Laurence; Lindner, Lars; Lerut, Evelyne; Wozniak, Agnieszka; Zakotnik, Branko; Marreaud, Sandrine; Collette, Sandra; Debiec-Rychter, Maria
    Effect of crizotinib on disease control in patient with advanced papillary renal cell carcinoma type 1 with MET mutations or amplification : Final results of EORTC 90101 CREATE
    In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 6 Suppl., pp. 580 - 580
    ISSN: 0732-183X; 1527-7755
  • van de Sande, Michiel; Leithner, Andreas; Staals, Eric; López Bastida, Julio; Stacchiotti, Silvia; Bauer, Sebastian; Mastboom, Monique; Schreuder, Bart; Healey, John H.; Gelderblom, Hans; Palmerini, Emanuela
    First prospective observational study in diffuse-type tenosynovial giant cell tumors.
    In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 15 Suppl., pp. 11560
    ISSN: 0732-183X; 1527-7755
  • Casali, P.G.; Abecassis, N.; Bauer, Sebastian; Biagini, R.; Bielack, S.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Brodowicz, T.; Broto, J.M.; Buonadonna, A.; De Álava, E.; Dei Tos, A.P.; Del Muro, X.G.; Dileo, P.; Eriksson, M.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Ferrari, S.; Frezza, A.M.; Gasperoni, S.; Gelderblom, H.; Gil, T.; Grignani, G.; Gronchi, A.; Haas, R.L.; Hannu, A.; Hassan, B.; Hohenberger, P.; Issels, R.; Joensuu, H.; Jones, R.L.; Judson, I.; Jutte, P.; Kaal, S.; Kasper, B.; Kopeckova, K.; Krákorová, D.A.; Le Cesne, A.; Lugowska, I.; Merimsky, O.; Montemurro, M.; Pantaleo, M.A.; Piana, R.; Picci, P.; Piperno-Neumann, S.; Pousa, A.L.; Reichardt, P.; Robinson, M.H.; Rutkowski, P.; Safwat, A.A.; Schöffski, P.; Sleijfer, S.; Stacchiotti, S.; Sundby Hall, K.; Unk, M.; Van Coevorden, F.; Van Der Graaf, W.; Whelan, J.; Wardelmann, E.; Zaikova, O.; Blay, J.Y.
    Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
    In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 4, pp. iv68 - iv78
    ISSN: 0923-7534; 0923-7534
  • Grünwald, Viktor; Schuler, Martin H.; Schöffski, Patrick; Kopp, Hans-Georg; Bauer, Sebastian; Kasper, Bernd; Lindner, Lars H.; Chemnitz, Jens M.; Crysandt, Martina; Stein, Alexander; Steffen, B.; Richter, Stephan; Kneba, Michael; Egerer, Gerlinde; Zimmermann, S.; Karch, Annika; Kunitz, Annegret
    Health-related quality of life (HR-QoL) in elderly soft tissue sarcoma (STS) patients from the randomized phase II EPAZ study comparing pazopanib (PAZ) and doxorubicin (DOX) in first line
    In: Annals of Oncology: official journal of the European Society for Medical Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii577
    ISSN: 0923-7534; 1569-8041
  • Whelan, Jeremy; Le Deley, Marie-Cecile; Dirksen, Uta; Le Teuff, Gwénaël; Brennan, Bernadette; Gaspar, Nathalie; Hawkins, Douglas S.; Amler, Susanne; Bauer, Sebastian; Bielack, Stefan; Blay, Jean-Yves; Burdach, Stefan; Castex, Marie-Pierre; Dilloo, Dagmar; Eggert, Angelika; Gelderblom, Hans; Gentet, Jean-Claude; Hartmann, Wolfgang; Hassenpflug, Wolf-Achim; Hjorth, Lars; Jimenez, Marta; Klingebiel, Thomas; Kontny, Udo; Kruseova, Jarmila; Ladenstein, Ruth; Laurence, Valerie; Lervat, Cyril; Marec-Berard, Perrine; Marreaud, Sandrine; Michon, Jean; Morland, Bruce; Paulussen, Michael; Ranft, Andreas; Reichardt, Peter; Van Den Berg, Hendrik; Wheatley, Keith; Judson, Ian; Lewis, Ian; Craft, Alan; Juergens, Heribert; Oberlin, Odile
    High-dose chemotherapy and blood autologous stem-cell rescue compared with standard chemotherapy in localized high-risk ewing sarcoma : Results of Euro-E.W.I.N.G.99 and Ewing-2008
    In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 31, pp. 3110 - 3119
    ISSN: 0732-183X; 1527-7755
  • Chudasama, Priya; Mughal, Sadaf S.; Schröck, Evelin; Glimm, Hanno; Kleinheinz, Kortine; Klink, Barbara; Brors, Benedikt; Hlevnjak, Mario; Gröschel, Stefan; Wolf, Stephan; Omlor, Georg; Ernst, Aurélie; Ulrich, Alexis; Deeg, Katharina I.; Mechtersheimer, Gunhild; Schimmack, Simon; Eils, Roland; Egerer, Gerlinde; Kasper, Bernd; Wong, Siao-Han; von Kalle, Christof; Hohenberger, Peter; Lehner, Burkhard; Rippe, Karsten; Chung, Inn; Bauer, Sebastian; Scholl, Claudia; Sieverling, Lina; Sanders, Mathijs A.; Hübschmann, Daniel; Heilig, Christoph E.; Hutter, Barbara; Renner, Marcus; Weichert, Wilko; Stenzinger, Albrecht; Schlesner, Matthias; Hoogenboezem, Remco M.; Kopp, Hans-Georg; Rabe, Sophie; Zapatka, Marc; Fröhling, Stefan
    Integrative genomic and transcriptomic analysis of leiomyosarcoma
    In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 144
    ISSN: 2041-1723
  • von Heydebreck, Anja; Lee, Keun Wook; Bauer, Sebastian; Nemunaitis, John J.; Chin, Kevin M.; Keilholz, Ulrich; Gulley, James L.; Bourgeois, Hugues Pierre; Taylor, Matthew H; Wyrwicz, Lucjan; Mehnert, Janice M.; Patel, Manish R.; Gravenor, Donald; Kasturi, Vijay
    Phase 1b results of avelumab in patients (pts) with previously treated metastatic melanoma enrolled in the JAVELIN Solid Tumor trial, including updated subgroup analyses
    In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 15 Suppl., pp. e21531
    ISSN: 0732-183X; 1527-7755
  • Casali, P.G.; Abecassis, N.; Bauer, Sebastian; Biagini, R.; Bielack, S.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Brodowicz, T.; Broto, J.M.; Buonadonna, A.; De Álava, E.; Dei Tos, A.P.; Del Muro, X.G.; Dileo, P.; Eriksson, M.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Ferrari, S.; Frezza, A.M.; Gasperoni, S.; Gelderblom, H.; Gil, T.; Grignani, G.; Gronchi, A.; Haas, R.L.; Hannu, A.; Hassan, B.; Hohenberger, P.; Issels, R.; Joensuu, H.; Jones, R.L.; Judson, I.; Jutte, P.; Kaal, S.; Kasper, B.; Kopeckova, K.; Krákorová, D.A.; Le Cesne, A.; Lugowska, I.; Merimsky, O.; Montemurro, M.; Pantaleo, M.A.; Piana, R.; Picci, P.; Piperno-Neumann, S.; Pousa, A.L.; Reichardt, P.; Robinson, M.H.; Rutkowski, P.; Safwat, A.A.; Schöffski, P.; Sleijfer, S.; Stacchiotti, S.; Sundby Hall, K.; Unk, M.; Van Coevorden, F.; Van Der Graaf, W.; Whelan, J.; Wardelmann, E.; Zaikova, O.; Blay, J.Y.
    Soft tissue and visceral sarcomas : ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
    In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 4, pp. iv51 - iv67
    ISSN: 1569-8041; 0923-7534
  • Hemming, M L; Heinrich, M C; Bauer, Sebastian; George, S
    Translational Insights into Gastrointestinal Stromal Tumor and Current Clinical Advances
    In: Annals of Oncology Vol. 29 (2018) Nr. 10, pp. 2037 - 2045
    ISSN: 0923-7534; 1569-8041
  • Pink, Daniel; Reichardt, Peter; Brodowicz, Thomas; Hohenberger, Peter; Richter, Stephan; Bauer, Sebastian; Kasper, Bernd
    Treatment of angiosarcoma with pazopanib and paclitaxel : Results of the phase II trial of the German Interdisciplinary Sarcoma Group (GISG-06 EVA) study
    In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 15 Suppl., pp. 11570
    ISSN: 0732-183X; 1527-7755
  • Bauer, Sebastian; George, Suzanne; Kang, Y.-K.; Tap, William D.; Zhou, T.; Picazio, N.; Boral, Andy L.; Heinrich, Michael
    VOYAGER : An open-label, randomised, phase III study of avapritinib vs regorafenib in patients (pts) with locally advanced (adv) metastatic or unresectable gastrointestinal stromal tumour (GIST)
    In: Annals of Oncology: official journal of the European Society for Medical Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii595
    ISSN: 0923-7534; 1569-8041
  • Wagner, Andrew J.; Kindler, Hedy Lee; Gelderblom, Hans J.; Schöffski, Patrick; Bauer, Sebastian; Hohenberger, Peter; Kopp, Hans Georg; Lopez-Martin, José Antonio; Peeters, Marc A.; Reichardt, Peter; Qin, Amy; Nippgen, Johannes B.W.; Ilaria, Robert L.; Rutkowski, Piotr L.
    A phase II study of a human anti-PDGFRα monoclonal antibody (olaratumab, IMC-3G3) in previously treated patients with metastatic gastrointestinal stromal tumors
    In: Annals of Oncology Vol. 28 (2017) Nr. 3, pp. 541 - 546
    ISSN: 1569-8041; 0923-7534
  • Schöffski, Patrick; Wozniak, A.; Stacchiotti, S.; Rutkowski, P.; Blay, J.-Y.; Lindner, L.H.; Strauss, S.J.; Anthoney, A.; Duffaud, F.; Richter, S.; Grünwald, V.; Leahy, M.G.; Reichardt, P.; Sufliarsky, J.; van der Graaf, W.T.; Sciot, R.; Debiec-Rychter, M.; Van Cann, T.; Marréaud, S.; Lia, M.; Raveloarivahy, T.; Collette, L.; Bauer, Sebastian
    Activity and safety of crizotinib in patients with advanced clear-cell sarcoma with MET alterations : European Organization for Research and Treatment of Cancer phase II trial 90101 'CREATE'
    In: Annals of Oncology Vol. 28 (2017) Nr. 12, pp. 3000 - 3008
    ISSN: 1569-8041; 0923-7534
  • Joensuu, Heikki; Wardelmann, Eva; Sihto, Harri; Eriksson, Mikael; Sundby Hall, Kirsten; Reichardt, Annette; Hartmann, Jörg T.; Pink, Daniel; Cameron, Silke; Hohenberger, Peter; Al-Batran, Salah-Eddin; Schlemmer, Marcus; Bauer, Sebastian; Nilsson, Bengt; Kallio, Raija; Junnila, Jouni; Vehtari, Aki; Reichardt, Peter
    Effect of KIT and PDGFRA mutations on survival in patients with gastrointestinal stromal tumors treated with adjuvant imatinib : An exploratory analysis of a randomized clinical trial
    In: JAMA Oncology Vol. 3 (2017) Nr. 5, pp. 602 - 609
    ISSN: 2374-2445; 2374-2437
  • Schaefer, Inga-Marie; Wang, Yuexiang; Liang, Cher-Wei; Bahri, Nacef; Quattrone, Anna; Doyle, Leona; Marinõ-Enríquez, Adrian; Lauria, Alexandra; Zhu, Meijun; Debiec-Rychter, Maria; Grunewald, Susanne; Hechtman, Jaclyn F.; Dufresne, Armelle; Antonescu, Cristina R.; Beadling, Carol; Sicinska, Ewa T.; Van De Rijn, Matt; Demetri, George D.; Ladanyi, Marc; Corless, Christopher L.; Heinrich, Michael C.; Raut, Chandrajit P.; Bauer, Sebastian; Fletcher, Jonathan A.
    MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation
    In: Nature Communications Vol. 8 (2017) pp. 14674
    ISSN: 2041-1723
  • Scheulen, Max Ernst; Kaempgen, Eckhart; Keilholz, Ulrich; Heinzerling, Lucie; Ochsenreither, Sebastian; Abendroth, Annalena; Huger, Ralf A.; Grubert, Matthias; Wetter, Axel; Guberina, Nika; Bauer, Sebastian; Schuler, Gerold; Bornfeld, Norbert; Schuler, Martin; Richly, Heike
    STREAM : A randomized discontinuation, blinded, placebo-controlled phase II study of sorafenib (5) treatment of chemonaive patients (pts) with metastatic uveal melanoma (MUM)
    In: Journal of Clinical Oncology Vol. 35 (2017) Nr. 15, pp. 9511
    ISSN: 0732-183X; 1527-7755
  • Kim, Won Kyu; Yun, SeongJu; Park, Cheol Keun; Bauer, Sebastian; Kim, Jiyoon; Lee, Min Goo; Kim, Hoguen
    Sustained mutant KIT activation in the Golgi complex is mediated by PKC-θ in gastrointestinal stromal tumors
    In: Clinical Cancer Research Vol. 23 (2017) Nr. 3, pp. 845 - 856
    ISSN: 1557-3265; 1078-0432
  • Blay, Jean-Yves; Schoffski, Patrick; Bauer, Sebastian; Krarup-Hansen, Anders; Benson, Charlotte; D'Adamo, David R.; Guo, Matthew; Maki, R.
    1401PD - Subgroup analysis of leiomyosarcoma (LMS) patients (pts) from a phase 3, open-label, randomized study of eribulin (ERI) versus dacarbazine (DTIC) in pts with advanced liposarcoma (LPS) and LMS
    In: Annals of Oncology Vol. 27 (2016) Nr. Suppl. 6, pp. vi485
    ISSN: 1569-8041; 0923-7534
  • Dummer, R.; Meille, C.; Demetri, G.; Van Bree, L.; Wuerthner, J.U.; Guerreiro, N.; Jeay, S.; Kumar, A.; Cassier, P.; Bauer, Sebastian; Tan, D.S.; Halilovic, E.
    A phase I, open-label, multi-center, dose escalation study of oral NVP-CGM097, a p53/HDM2-protein-protein interaction inhibitor, in adult patients with selected advanced solid tumors
    In: Annals of Oncology Vol. 27 (2016) Nr. Suppl. 6, pp. 366PD
    ISSN: 1569-8041; 0923-7534
  • Joensuu, Heikki; Eriksson, Mikael; Sundby Hall, Kirsten; Reichardt, Annette; Hartmann, Jörg T; Pink, Daniel; Ramadori, Giuliano; Hohenberger, Peter; Al-Batran, Salah-Eddin; Schlemmer, Marcus; Bauer, Sebastian; Wardelmann, Eva; Nilsson, Bengt; Sihto, Harri; Bono, Petri; Kallio, Raija; Junnila, Jouni; Alvegård, Thor; Reichardt, Peter
    Adjuvant Imatinib for High-Risk GI Stromal Tumor : Analysis of a Randomized Trial
    In: Journal of Clinical Oncology Vol. 34 (2016) Nr. 3, pp. 244 - 250
    ISSN: 0732-183X; 1527-7755
  • Kasper, Bernd; Gruenwald, Viktor; Reichardt, Peter; Bauer, Sebastian; Hohenberger, Peter; Haller, Florian
    Correlation of CTNNB1 Mutation Status with Progression Arrest Rate in RECIST Progressive Desmoid-Type Fibromatosis Treated with Imatinib : Translational Research Results from a Phase 2 Study of the German Interdisciplinary Sarcoma Group (GISG-01)
    In: Annals of Surgical Oncology Vol. 23 (2016) Nr. 6, pp. 1924 - 1927
    ISSN: 1068-9265; 1534-4681
  • Schöffski, Patrick; Guo, Matthew; Hohenberger, Peter; Blay, Jean-Yves; Rha, Sun Young; Bauer, Sebastian; Choy, Edwin; Gelderblom, Hans; Italiano, Antoine; Maki, Robert; Chawla, Sant
    Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma : a randomised, open-label, multicentre, phase 3 trial
    In: The lancet Vol. 387 (2016) Nr. 10028, pp. 1629 - 1637
    ISSN: 0023-7507; 0140-6736
  • Engel, Julian; Becker, Christian; Lategahn, Jonas; Keul, Marina; Ketzer, Julia; Mühlenberg, Thomas; Kollipara, Laxmikanth; Schultz-Fademrecht, Carsten; Zahedi, René P; Bauer, Sebastian; Rauh, Daniel
    Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR
    In: Angewandte Chemie International Edition Vol. 55 (2016) Nr. 36, pp. 10909 - 10912
    ISSN: 0570-0833; 1521-3773
  • Schoffski, Patrick; Wozniak, Agnieszka; Stacchiotti, Silvia; Rutkowski, Piotr; Debiec-Rychter, Maria; Sciot, Raf; Blay, Jean-Yves; Lindner, Lars; Strauss, Sandra J; Anthoney, David Alan; Leahy, Michael Gordon; Reichardt, Peter; Marreaud, Sandrine; Collette, Sandra; Steuve, Jonathan; Raveloarivahy, Tiana; Bauer, Sebastian
    Activity of crizotinib (C) in patients (pts) with clear cell sarcoma (CCSA) in EORTC phase II trial 90101
    In: Journal of Clinical Oncology Vol. 33 (2015) Nr. 15_suppl, pp. 10542
    ISSN: 0732-183X; 1527-7755
  • Weisner, Jörn; Gontla, Rajesh; van der Westhuizen, Leandi; Oeck, Sebastian; Ketzer, Julia; Janning, Petra; Richters, André; Mühlenberg, Thomas; Fang, Zhizhou; Taher, Abu; Jendrossek, Verena; Pelly, Stephen C; Bauer, Sebastian; van Otterlo, Willem A L; Rauh, Daniel
    Covalent-Allosteric Kinase Inhibitors
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    ISSN: 0570-0833; 1521-3773; 1433-7851
  • Gruenwald, Viktor; Kunitz, Annegret; Schuler, Markus Kajo; Kopp, Hans-Georg; Kasper, Bernd; Lindner, Lars; Chemnitz, Jens Marcus; Stein, Alexander; Schoeffski, Patrick; Steffen, Bjoern; Bauer, Sebastian; Egerer, Gerlinde; Kneba, Michael; Crysandt, Martina; Koch, Achim
    EPAZ : A randomized phase II trial comparing pazopanib with doxorubicin as first line treatment in elderly patients with metastatic or advanced soft tissue sarcoma of the Working Group Medical Oncology (AIO) and German Interdisciplinary Sarcoma Group (GISG)
    In: Journal of Clinical Oncology Vol. 33 (2015) Nr. 15_suppl, pp. TPS10576
    ISSN: 0732-183X; 1527-7755
  • Mross, Klaus B.; Scharr, Dirk; Richly, Heike; Bauer, Sebastian; Krauss, Babett; Krauss, Rolf; Hauns, Bernhard; Prenzel, Tanja; Kohlhof, Hella; Baumgartner, Roland; Scheulen, Max Ernst
    Overcoming the proliferation rate paradox : Clinical evaluation of a continuous dosing scheme of the novel oral Eg5 inhibitor 4SC-205
    In: Journal of Clinical Oncology Vol. 33 (2015) Nr. 15_suppl, pp. 2528
    ISSN: 0732-183X; 1527-7755
  • Bauer, Sebastian; Herold, Thomas; Mühlenberg, Thomas; Reis, Anna-Carina; Falkenhorst, Johanna; Backs, Miriam; Ketzer, Julia; Breitenbücher, Frank; Schuler, Martin; Grunewald, Susanne
    Plasma sequencing to detect a multitude of secondary KIT resistance mutations in metastatic gastrointestinal stromal tumors (GIST)
    In: Journal of Clinical Oncology Vol. 33 (2015) Nr. 15_suppl, pp. 10518
    ISSN: 0732-183X; 1527-7755
  • Schoeffski, Patrick; Maki, Robert G.; Italiano, Antoine; Gelderblom, Hans; Grignani, Giovanni; De Camargo, Veridiana Pires; Bauer, Sebastian; Rha, Sun Young; Chawla, Sant P.; Blay, Jean-Yves; Hohenberger, Peter; D'Adamo, David R.; Wang, Benjamin; Chmielowski, Bartosz; Le Cesne, Axel; Demetri, George D.; Patel, Shreyaskumar
    Randomized, open-label, multicenter, phase III study of eribulin versus dacarbazine in patients (pts) with leiomyosarcoma (LMS) and adipocytic sarcoma (ADI)
    In: Journal of Clinical Oncology Vol. 33 (2015) Nr. 15_suppl, pp. LBA7005
    ISSN: 0732-183X; 1527-7755
  • Winer, Eric S.; Safran, Howard; Forget, Frederic; Karaszewska, Boguslawa; Bauer, Sebastian; Khan, Dilawar; Johnson, Brendan Mark; Burgess, Paul M.; Althouse, Denise C.; Chan, Geoffrey; Kamel, Yasser Mostafa
    Safety and efficacy of eltrombopag (EPAG) vs placebo (PBO) for treatment of chemotherapy (CTx)-induced thrombocytopenia (TCP) in patients (Pts) with solid tumors receiving gemcitabine (GEM)-based CTx : A phase 2 study
    In: Journal of Clinical Oncology Vol. 33 (2015) Nr. 15_suppl, pp. 9602
    ISSN: 0732-183X; 1527-7755
  • Joensuu, Heikki; Eriksson, Mikael; Hall, Kirsten Sundby; Reichardt, Annette; Ramadori, Giuliano; Hohenberger, Peter; Al-Batran, Salah-Eddin; Schlemmer, Marcus; Bauer, Sebastian; Pink, Daniel; Duyster, Justus; Nilsson, Bengt E; Monge, Odd R.; Kallio, Raija; Bono, Petri; Junnila, Jouni; Wardelmann, Eva; Alvegard, Thor; Reichardt, Peter
    Three vs. 1 year of adjuvant imatinib (IM) for operable high-risk GIST : The second planned analysis of the randomized SSGXVIII/AIO trial
    In: Journal of Clinical Oncology Vol. 33 (2015) Nr. 15_suppl, pp. 10505
    ISSN: 0732-183X; 1527-7755
  • Sobrero, Alberto F.; Bordonaro, Roberto; Bencardino, Katia; Pietrantonio, Filippo; Bauer, Sebastian; Taieb, Julien; Garreau-Laporte, Pascale; Zilocchi, Chiara; Dochy, Emmanuelle; Lledo, Gerard
    Ziv-aflibercept in combination with FOLFIRI for 2nd-line treatment of patients with metastatic colorectal cancer : Interim safety data from the global aflibercept safety and quality-of-life program (ASQoP/AFEQT) in patients pretreated with bevacizumab
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    ISSN: 0732-183X; 1527-7755
  • Holczyk, M.; Herbrik, M.; Grabellus, Florian; Podleska, Lars; Pöttgen, Christoph; Schwindenhammer, B.; Bekas, V.; Schuler, Martin; Bauer, Sebastian
    Brain metastases in sarcoma patients : Incidence and outcome
    In: Journal of Clinical Oncology Vol. 32 (2014) Nr. 15 Suppl., pp. 10591
    ISSN: 0732-183X; 1527-7755
  • Grunewald, Susanne; Mühlenberg, Thomas; Rubin, B.; Schuler, Martin; Fletcher, J. A.; Bauer, Sebastian
    Effect of secondary KIT mutations on growth of GIST cells in the absence of selective pressure by imatinib in isogenic models of imatinib resistance
    In: Journal of Clinical Oncology Vol. 32 (2014) Nr. 15 Suppl., pp. 10555
    ISSN: 0732-183X; 1527-7755
  • Mross, K. B.; Scharr, D.; Richly, Heike; Frost, A.; Bauer, Sebastian; Krause, B.; Krause, R.; Mals, A.; Hauns, B.; Hentsch, B.; Baumgartner, R.; Scheulen, Max Ernst
    First-in-human study of 4SC-205 (AEGIS), a novel oral inhibitor of Eg5 kinesin spindle protein
    In: Journal of Clinical Oncology Vol. 32 (2014) Nr. 15 Suppl., pp. 2564
    ISSN: 0732-183X; 1527-7755
  • Kasper, B; Sleijfer, S; Litière, S; Marreaud, S; Verweij, J; Hodge, R A; Bauer, Sebastian; Kerst, J M; van der Graaf, W T A
    Long-term responders and survivors on pazopanib for advanced soft tissue sarcomas : subanalysis of two European Organisation for Research and Treatment of Cancer (EORTC) clinical trials 62043 and 62072
    In: Annals of Oncology Vol. 25 (2014) Nr. 3, pp. 719 - 724
    ISSN: 0923-7534; 1569-8041
  • Mühlenberg, T.; Grunewald, S.; Schuler, Martin; Bauer, Sebastian
    Targeting glucose metabolism by 2-deoxyglucose in gastrointestinal stromal tumors
    In: Cancer Research Vol. 74 (2014) Nr. 19 Suppl.,
    ISSN: 0008-5472; 1538-7445
  • Ferry, D. R.; Sobrero, A. F.; Bordonaro, R.; Siena, S.; Pietrantonio, F.; Bauer, Sebastian; Taieb, J.; Garreau-Laporte, P.; Brette, S.; Dochy, E.; Lledo, G.
    Ziv-aflibercept (Z) in combination with FOLFIRI for second-line treatment of patients (pts) with metastatic colorectal cancer (mCRC) : Interim safety data from the global aflibercept safety and quality-of-life program in pts pretreated with bevacizumab (B)
    In: Journal of Clinical Oncology Vol. 33 (2014) Nr. 3 Suppl., pp. 528
    ISSN: 0732-183X; 1527-7755
  • Simon, Susanne; Grabellus, Florian; Ferrera, Loretta; Galietta, Luis; Schwindenhammer, Benjamin; Mühlenberg, Thomas; Täger, Georg; Eilers, Grant; Treckmann, Jürgen Walter; Breitenbücher, Frank; Schuler, Martin; Taguchi, Takahiro; Fletcher, Jonathan A.; Bauer, Sebastian
    DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
    In: Cancer Research Vol. 73 (2013) Nr. 12, pp. 3661 - 3670
    ISSN: 0008-5472; 1538-7445
  • Demetri, G. D.; Jeffers, M.; Reichardt, P.; Kang, Y. K.; Blay, J. Y.; Rutkowski, P.; Gelderblom, H.; Hohenberger, P.; Leahy, M.; von Mehren, M.; Joensuu, H.; Badalamenti, G.; Blackstein, M.; Le Cesne, A.; Schoffski, P.; Maki, R. G.; Bauer, Sebastian; Nguyen, B. B.; Xu, J. M.; Nishida, T.; Chung, J.; Lathia, C. D.; Kappeler, C.; Kuss, I.; Laurent, D.; Casali, P. G.
    Detection of oncogenic kinase mutations in circulating plasma DNA and correlation with clinical benefit in the phase III GRID study of regorafenib vs placebo in TKI-refractory metastatic GIST
    In: Cancer Research Vol. 73 (2013) Nr. Suppl. 8,
    ISSN: 0008-5472; 1538-7445
  • Demetri, G. D.; Reichardt, P.; Kang, Y. K.; Blay, J. Y.; Rutkowski, P.; Gelderblom, H.; Hohenberger, P.; Leahy, M.; von Mehren, M.; Joensuu, H.; Badalamenti, G.; Blackstein, M.; Le Cesne, A.; Schöffski, P.; Maki, R. G.; Bauer, Sebastian; Nguyen, B. B.; Xu, J.; Nishida, T.; Chung, J.; Kappeler, C.; Kuss, I.; Laurent, D.; Casali, P. G.; GRID study investigators
    Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID) : an international, multicentre, randomised, placebo-controlled, phase 3 trial
    In: The Lancet Vol. 381 (2013) Nr. 9863, pp. 295 - 302
    ISSN: 0140-6736; 1474-547X
  • Kasper, B.; Litiere, S.; Marreaud, S.; Sleijfer, S.; Verweij, J.; Bauer, Sebastian; Kerst, J. M.; Van der Graaf, WTA
    Long-term responders and survivors on pazopanib for soft tissue sarcomas (STS) : Subanalysis of two European Organisation for Research and Treatment of Cancer (EORTC) clinical trials 62043 and 62072
    In: Journal of Clinical Oncology Vol. 31 (2013) Nr. 15 Suppl., pp. 10553
    ISSN: 0732-183X; 1527-7755
  • Rutkowski, P.; Gronchi, A.; Hohenberger, P.; Bonvalot, S.; Schöffski, P.; Bauer, Sebastian; Fumagalli, E.; Nyckowski, P.; Nguyen, B. P.; Kerst, J. M.; Fiore, M.; Bylina, E.; Hoiczyk, M.; Cats, A.; Casali, P. G.; Le Cesne, A.; Treckmann, Jürgen Walter; Stoeckle, E.; de Wilt, J. H.; Sleijfer, S.; Tielen, R.; van der Graaf, W.; Verhoef, C.; van Coevorden, F.
    Neoadjuvant Imatinib in Locally Advanced Gastrointestinal Stromal Tumors (GIST) : The EORTC STBSG Experience
    In: Annals of Surgical Oncology Vol. 20 (2013) Nr. 9, pp. 2937 - 2943
    ISSN: 1068-9265; 1534-4681
  • Schuler, Martin; Zvirbule, Z.; Lordick, F.; Krilova, A.; Helbig, U.; Schulze-Bergkamen, H.; Thuss-Patience, P. C.; von Wichert, G.; Schulmann, K.; Trarbach, Tanja; Bauer, Sebastian; Mueller, C.; Al-Batran, S. E.; Huber, C.; Sahin, U.; Tureci, O.
    Safety, tolerability, and efficacy of the first-in-class antibody IMAB362 targeting claudin 18.2 in patients with metastatic gastroesophageal adenocarcinomas
    In: Journal of Clinical Oncology Vol. 31 (2013) Nr. 15 Suppl., pp. 4080
    ISSN: 0732-183X; 1527-7755
  • Heinrich, M. C.; Fletcher, J. A.; Anjum, R.; Serrano-Garcia, C.; Vodala, S.; Bauer, Sebastian; Town, A.; Zhu, M. J.; Ning, Y. Y.; Eilers, G.; Griffith, D.; Patterson, J.; McKinley, A.; Wang, F. Y.; Garner, A. P.; Rivera, V. M.
    Use of ponatinib to inhibit kinase mutations associated with drug-resistant gastrointestinal stromal tumors (GIST)
    In: Journal of Clinical Oncology Vol. 31 (2013) Nr. 15 Suppl., pp. 10509
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  • Joensuu, H.; Eriksson, M.; Sundby Hall, K.; Hartmann, J. T.; Pink, D.; Schütte, Jochen; Ramadori, G.; Hohenberger, P.; Duyster, J.; Al-Batran, S. E.; Schlemmer, M.; Bauer, Sebastian; Wardelmann, E.; Sarlomo-Rikala, M.; Nilsson, B.; Sihto, H.; Monge, O. R.; Bono, P.; Kallio, R.; Vehtari, A.; Leinonen, M.; Alvegård, T.; Reichardt, P.
    One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor : a randomized trial
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    ISSN: 0098-7484; 1538-3598
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    Phase I trial of panobinostat (P) and imatinib (IM) in patients with treatment-refractory gastrointestinal stromal tumors (GIST)
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    ISSN: 0732-183X; 1527-7755
  • Hoiczyk, M.; Kuschel, P.; Grabellus, Florian; Geffken, M.; Ahrens, M.; Schuler, Martin; Bauer, Sebastian
    Rechallenge with ifosfamide-containing regimen as salvage option for patients with metastatic soft tissue sarcomas progressing after multiple pretreatments
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    ISSN: 0732-183X; 1527-7755
  • Nguyen, B.; Grabellus, Florian; Hoiczyk, M.; Täger, Georg; Schuler, Martin; Bauer, Sebastian
    Long-term follow-up of patients with GIST undergoing metastasectomy in the era of imatinib (IM)
    In: Journal of Clinical Oncology Vol. 28 (2010) Nr. Suppl. 15, pp. 10047
    ISSN: 0732-183X; 1527-7755
  • Bauer, Sebastian; Parry, Joshua A.; Mühlenberg, Thomas; Brown, Matthew F.; Seneviratne, Danushka; Chatterjee, Payel; Chin, Anna; Rubin, Brian P.; Kuan, Shih-Fan; Fletcher, Jonathan A.; Duensing, Stefan; Duensing, Anette
    Proapoptotic activity of bortezomib in gastrointestinal stromal tumor cells
    In: Cancer Research Vol. 70 (2010) Nr. 1, pp. 150 - 159
    ISSN: 0008-5472; 1538-7445; 0099-7013; 0099-7374