ZMB Member Sebastian Bauer

ZMB Member
Sebastian Bauer

Next ZMB-Member
Sebastian Bauer
© UKE/S.Bauer

Prof. Dr. Sebastian Bauer

Group

Translational Sarcoma Research

West German Cancer Center (WTZ)
University Hospital Essen
Hufelandstr. 55
45147 Essen

Research Overview

  1. Analysis of oncogenetic signalling pathways in soft-tissue sarcoma (esp. GIST)
  2. Evaluation of purposive, small molecular inhibitors of tyrosine kinases in soft-tissue sarcoma
  3. Development of soft-tissue sarcoma models (cell lines and Xenografts)
  4. Evaluation of preclinical diagnostic techniques/methods (in vitro/in vivo) for GIST and other soft-tissue sarcoma
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Selected Publications

    Journal articles

  • Teuber, A.; Schulz, T.; Fletcher, B.S.; Gontla, R.; Mühlenberg, Thomas; Zischinsky, M.-L.; Niggenaber, J.; Weisner, J.; Kleinbölting, S.B.; Lategahn, J.; Sievers, S.; Müller, M.P.; Bauer, Sebastian; Rauh, D.
    Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA
    In: Nature Communications Vol. 15 (2024) Nr. 1, 63
    Online Full Text: dx.doi.org/ (Open Access)
  • Tretter, Celina; de Andrade Krätzig, Niklas; Pecoraro, Matteo; Lange, Sebastian; Seifert, Philipp; von Frankenberg, Clara; Untch, Johannes; Zuleger, Gabriela; Wilhelm, Mathias; Zolg, Daniel P.; Dreyer, Florian S.; Bräunlein, Eva; Engleitner, Thomas; Uhrig, Sebastian; Boxberg, Melanie; Steiger, Katja; Slotta-Huspenina, Julia; Ochsenreither, Sebastian; von Bubnoff, Nikolas; Bauer, Sebastian; Boerries, Melanie; Jost, Philipp J.; Schenck, Kristina; Dresing, Iska; Bassermann, Florian; Friess, Helmut; Reim, Daniel; Grützmann, Konrad; Pfütze, Katrin; Klink, Barbara; Schröck, Evelin; Haller, Bernhard; Kuster, Bernhard; Mann, Matthias; Weichert, Wilko; Fröhling, Stefan; Rad, Roland; Hiltensperger, Michael; Krackhardt, Angela M.
    Correction to: Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification
    In: Nature Communications Vol. 15 (2024) Nr. 1, 2364
    Online Full Text: dx.doi.org/ (Open Access)
  • Heinrich, Michael C.; Jones, Robin L.; George, Suzanne; Gelderblom, Hans; Schöffski, Patrick; von Mehren, Margaret; Zalcberg, John R.; Kang, Yoon-Koo; Razak, Albiruni Abdul; Trent, Jonathan; Attia, Steven; Le Cesne, Axel; Siontis, Brittany L.; Goldstein, David; Boye, Kjetil; Sanchez, Cesar; Steeghs, Neeltje; Rutkowski, Piotr; Druta, Mihaela; Serrano, César; Somaiah, Neeta; Chi, Ping; Reichmann, William; Sprott, Kam; Achour, Haroun; Sherman, Matthew L.; Ruiz-Soto, Rodrigo; Blay, Jean-Yves; Bauer, Sebastian
    Ripretinib versus sunitinib in gastrointestinal stromal tumor : ctDNA biomarker analysis of the phase 3 INTRIGUE trial
    In: Nature Medicine (2024) in press
    Online Full Text: dx.doi.org/ (Open Access)
  • Serrano, C.; Bauer, Sebastian; Gómez-Peregrina, D.; Kang, Y.-K.; Jones, R.L.; Rutkowski, P.; Mir, O.; Heinrich, M.C.; Tap, W.D.; Newberry, K.; Grassian, A.; Shi, H.; Bialick, S.; Schöffski, P.; Pantaleo, M.A.; von Mehren, M.; Trent, J.C.; George, S.
    Circulating tumor DNA analysis of the phase III VOYAGER trial : KIT mutational landscape and outcomes in patients with advanced gastrointestinal stromal tumor treated with avapritinib or regorafenib
    In: Annals of Oncology Vol. 34 (2023) Nr. 7, pp. 615 - 625
    Online Full Text: dx.doi.org/
  • Joensuu, Heikki; Wardelmann, Eva; Eriksson, Mikael; Reichardt, Annette; Hall, Kirsten Sundby; Schütte, Jochen; Cameron, Silke; Hohenberger, Peter; Sihto, Harri; Jost, Philipp J.; Lindner, Lars H.; Bauer, Sebastian; Nilsson, Bengt; Kallio, Raija; Pesonen, Tommi; Reichardt, Peter
    KIT and PDGFRA Mutations and Survival of Gastrointestinal Stromal Tumor Patients Treated with Adjuvant Imatinib in a Randomized Trial
    In: Clinical Cancer Research Vol. 29 (2023) Nr. 17, pp. 3313 - 3319
    Online Full Text: dx.doi.org/ (Open Access)
  • Tretter, Celina; de Andrade Krätzig, Niklas; Pecoraro, Matteo; Lange, Sebastian; Seifert, Philipp; von Frankenberg, Clara; Untch, Johannes; Zuleger, Gabriela; Wilhelm, Mathias; Zolg, Daniel P.; Dreyer, Florian S.; Bräunlein, Eva; Engleitner, Thomas; Uhrig, Sebastian; Boxberg, Melanie; Steiger, Katja; Slotta-Huspenina, Julia; Ochsenreither, Sebastian; von Bubnoff, Nikolas; Bauer, Sebastian; Boerries, Melanie; Jost, Philipp J.; Schenck, Kristina; Dresing, Iska; Bassermann, Florian; Friess, Helmut; Reim, Daniel; Grützmann, Konrad; Pfütze, Katrin; Klink, Barbara; Schröck, Evelin; Haller, Bernhard; Kuster, Bernhard; Mann, Matthias; Weichert, Wilko; Fröhling, Stefan; Rad, Roland; Hiltensperger, Michael; Krackhardt, Angela M.
    Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification
    In: Nature Communications Vol. 14 (2023) Nr. 1, pp. 4632
    Online Full Text: dx.doi.org/ (Open Access)
  • Koch, Raphael; Haveman, Lianne; Ladenstein, Ruth; Brichard, Benedicte; Jürgens, Heribert; Cyprova, Sona; van den Berg, Henk; Hassenpflug, Wolf; Raciborska, Anna; Ek, Torben; Baumhoer, Daniel; Egerer, Gerlinde; Kager, Leo; Renard, Marleen; Hauser, Peter; Burdach, Stefan; Bovee, Judith V M G; Hong, Angela M.; Reichardt, Peter; Kruseova, Jarmila; Streitbürger, Arne; Kühne, Thomas; Kessler, Torsten; Bernkopf, Marie; Butterfaß-Bahloul, Trude; Dhooge, Catharina; Bauer, Sebastian; Kiss, János; Paulussen, Michael; Bonar, Fiona; Ranft, Andreas; Timmermann, Beate; Rascon, Jelena; Vieth, Volker; Kanerva, Jukka; Faldum, Andreas; Hartmann, Wolfgang; Hjorth, Lars; Bhadri, Vivek A.; Metzler, Markus; Gelderblom, Hans; Dirksen, Uta
    Zoledronic Acid Add-on Therapy for Standard-Risk Ewing Sarcoma Patients in the Ewing 2008R1 Trial
    In: Clinical Cancer Research Vol. 29 (2023) Nr. 24, pp. 5057 - 5068
    Online Full Text: dx.doi.org/
  • Vincenzi, Bruno; Napolitano, Andrea; Fiocco, Marta; Mir, Olivier; Rutkowski, Piotr; Blay, Jean-Yves; Reichardt, Peter; Joensuu, Heikki; Fumagalli, Elena; Gennatas, Spyridon; Hindi, Nadia; Nannini, Margherita; Ceruso, Mariella Spalato; Italiano, Antoine; Grignani, Giovanni; Brunello, Antonella; Gasperoni, Silvia; De Pas, Tommaso; Badalamenti, Giuseppe; Pantaleo, Maria A.; Van Houdt, Winan J.; IJzerman, Nikki S.; Steeghs, Neeltje; Gelderblom, Hans; Desar, Ingrid M.E.; Falkenhorst, Johanna; Silletta, Marianna; Sbaraglia, Marta; Tonini, Giuseppe; Martin-Brot, Javier; Hohenberger, Peter; Le Cesne, Axel; Jones, Robin L.; Dei Tos, Angelo P.; Gronchi, Alessandro; Bauer, Sebastian; Casali, Paolo G.
    Adjuvant Imatinib in Patients with GIST Harboring Exon 9 KIT Mutations : Results from a Multi-institutional European Retrospective Study
    In: Clinical Cancer Research Vol. 28 (2022) Nr. 8, pp. 1672 - 1679
    Online Full Text: dx.doi.org/ (Open Access)
  • Abdul Razak, Albiruni R.; Bauer, Sebastian; Suarez, Cristina; Lin, Chia-Chi; Quek, Richard; Hütter-Krönke, Marie Luise; Cubedo, Ricardo; Ferretti, Stephane; Guerreiro, Nelson; Jullion, Astrid; Orlando, Elena J.; Clementi, Giorgia; Dejmek, Janna Sand; Halilovic, Ensar; Fabre, Claire; Blay, Jean-Yves; Italiano, Antoine; Sand Dejmek, Janna
    Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma : Results from a Proof-of-Concept, Phase Ib Study
    In: Clinical Cancer Research Vol. 28 (2022) Nr. 6, pp. 1087 - 1097
    Online Full Text: dx.doi.org/ (Open Access)
  • Jahn, A.; Rump, A.; Widmann, T.J.; Heining, C.; Horak, P.; Hutter, B.; Paramasivam, N.; Uhrig, S.; Gieldon, L.; Drukewitz, S.; Kübler, A.; Bermudez, M.; Hackmann, K.; Porrmann, J.; Wagner, J.; Arlt, M.; Franke, M.; Fischer, J.; Kowalzyk, Z.; William, D.; Weth, V.; Oster, S.; Fröhlich, M.; Hüllein, J.; Valle González, C.; Kreutzfeldt, S.; Mock, A.; Heilig, C.E.; Lipka, D.B.; Möhrmann, L.; Hanf, D.; Oleś, M.; Teleanu, V.; Allgäuer, M.; Ruhnke, L.; Kutz, O.; Knurr, A.; Laßmann, A.; Endris, V.; Neumann, O.; Penzel, R.; Beck, K.; Richter, D.; Winter, U.; Wolf, S.; Pfütze, K.; Geörg, C.; Meißburger, B.; Buchhalter, I.; Augustin, M.; Aulitzky, W.E.; Hohenberger, P.; Kroiss, M.; Schirmacher, P.; Schlenk, R.F.; Keilholz, U.; Klauschen, F.; Folprecht, G.; Bauer, Sebastian; Siveke, Jens; Brandts, C.H.; Kindler, T.; Boerries, M.; Illert, A.L.; von Bubnoff, N.; Jost, P.J.; Metzeler, K.H.; Bitzer, M.; Schulze-Osthoff, K.; von Kalle, C.; Brors, B.; Stenzinger, A.; Weichert, W.; Hübschmann, D.; Fröhling, S.; Glimm, H.; Schröck, E.; Klink, B.
    Comprehensive cancer predisposition testing within the prospective MASTER trial identifies hereditary cancer patients and supports treatment decisions for rare cancers
    In: Annals of Oncology Vol. 33 (2022) Nr. 11, pp. 1186 - 1199
    Online Full Text: dx.doi.org/ (Open Access)
  • Casali, P. G.; Blay, J. Y.; Bauer, Sebastian; Stacchiotti, S.; et al.
    Gastrointestinal stromal tumours : ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up
    In: Annals of Oncology Vol. 33 (2022) Nr. 1, pp. 20 - 33
    Online Full Text: dx.doi.org/ (Open Access)
  • Stork, Theresa; Hegedüs, Balazs; Guder, Wiebke; Hamacher, Rainer; Hardes, Jendrik; Kaths, Moritz; Plönes, Till; Pöttgen, Christoph; Schildhaus, Hans-Ulrich; Streitbürger, Arne; Treckmann, Juergen; Bauer, Sebastian; Aigner, Clemens; Collaud, Stéphane
    Prognostic Factors for Leiomyosarcoma with Isolated Metastases to the Lungs : Impact of Metastasectomy
    In: Annals of Surgical Oncology Vol. 29 (2022) Nr. 7, pp. 4429 - 4436
    Online Full Text: dx.doi.org/ (Open Access)
  • Stein, Eytan M.; DeAngelo, Daniel J.; Chromik, Jörg; Chatterjee, Manik; Bauer, Sebastian; Lin, Chia-Chi; Suarez, Cristina; de Vos, Filip; Steeghs, Neeltje; Cassier, Philippe A.; Tai, David; Kiladjian, Jean-Jacques; Yamamoto, Noboru; Mous, Rogier; Esteve, Jordi; Minami, Hironobu; Ferretti, Stephane; Guerreiro, Nelson; Meille, Christophe; Radhakrishnan, Rajkumar; Pereira, Bernard; Mariconti, Luisa; Halilovic, Ensar; Fabre, Claire; Carpio, Cecilia; Cassier, Phillippe A.
    Results from a First-in-Human Phase I Study of Siremadlin (HDM201) in Patients with Advanced Wild-Type TP53 Solid Tumors and Acute Leukemia
    In: Clinical Cancer Research Vol. 28 (2022) Nr. 5, pp. 870 - 881
    Online Full Text: dx.doi.org/ (Open Access)
  • Fendler, Wolfgang; Pabst, Kim M.; Kessler, Lukas; Fragoso Costa, Pedro; Ferdinandus, Justin; Weber, Manuel; Lippert, Maria; Lückerath, Katharina; Umutlu, Lale; Kostbade, Karina; Mavroeidi, Ilektra A.; Schuler, Martin; Ahrens, Marit; Rischpler, Christoph; Bauer, Sebastian; Herrmann, Ken; Siveke, Jens; Hamacher, Rainer
    Safety and Efficacy of 90Y-FAPI-46 Radioligand Therapy in Patients with Advanced Sarcoma and Other Cancer Entities
    In: Clinical Cancer Research Vol. 28 (2022) Nr. 19, pp. 4346 - 4353
    Online Full Text: dx.doi.org/ (Open Access)
  • Strauss, S.J.; Frezza, A.M.; Abecassis, N.; Bajpai, J.; Bauer, Sebastian; Biagini, R.; Bielack, S.; Blay, J.Y.; Bolle, S.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Boye, K.; Brennan, B.; Brodowicz, T.; Buonadonna, A.; de Álava, E.; Dei Tos, A.P.; Garcia del Muro, X.; Dufresne, A.; Eriksson, M.; Fagioli, F.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Gaspar, N.; Gasperoni, S.; Gelderblom, H.; Gouin, F.; Grignani, G.; Gronchi, A.; Haas, R.; Hassan, A.B.; Hecker-Nolting, S.; Hindi, N.; Hohenberger, P.; Joensuu, H.; Jones, R.L.; Jungels, C.; Jutte, P.; Kager, L.; Kasper, B.; Kawai, A.; Kopeckova, K.; Krákorová, D.A.; Le Cesne, A.; Le Grange, F.; Legius, E.; Leithner, A.; López Pousa, A.; Martin-Broto, J.; Merimsky, O.; Messiou, C.; Miah, A.B.; Mir, O.; Montemurro, M.; Morland, B.; Morosi, C.; Palmerini, E.; Pantaleo, M.A.; Piana, R.; Piperno-Neumann, S.; Reichardt, P.; Rutkowski, P.; Safwat, A.A.; Sangalli, C.; Sbaraglia, M.; Scheipl, S.; Schöffski, P.; Sleijfer, S.; Strauss, D.; Sundby Hall, K.; Trama, A.; Unk, M.; van de Sande, M.A.J.; van der Graaf, W.T.A.; van Houdt, W.J.; Frebourg, T.; Ladenstein, R.; Casali, P.G.; Stacchiotti, S.
    Bone sarcomas : ESMO–EURACAN–GENTURIS–ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up
    In: Annals of Oncology Vol. 32 (2021) Nr. 12, pp. 1520 - 1536
    Online Full Text: dx.doi.org/ (Open Access)
  • Bauer, Sebastian; Heinrich, Michael C.; George, Suzanne; Zalcberg, John R.; Serrano, César; Gelderblom, Hans; Jones, Robin L.; Attia, Steven; D'Amato, Gina; Chi, Ping; Reichardt, Peter; Meade, Julie; Su, Ying; Ruiz-Soto, Rodrigo; Blay, Jean-Yves; von Mehren, Margaret; Schöffski, Patrick
    Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study
    In: Clinical Cancer Research Vol. 27 (2021) Nr. 23, pp. 6333 - 6342
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Horak, Peter; Heining, Christoph; Kreutzfeldt, Simon; Hutter, Barbara; Mock, Andreas; Hüllein, Jennifer; Fröhlich, Martina; Uhrig, Sebastian; Jahn, Arne; Rump, Andreas; Gieldon, Laura; Möhrmann, Lino; Hanf, Dorothea; Teleanu, Veronica; Heilig, Christoph E.; Lipka, Daniel B.; Allgäuer, Michael; Ruhnke, Leo; Laßmann, Andreas; Endris, Volker; Neumann, Olaf; Penzel, Roland; Beck, Katja; Richter, Daniela; Winter, Ulrike; Wolf, Stephan; Pfütze, Katrin; Geörg, Christina; Meißburger, Bettina; Buchhalter, Ivo; Augustin, Marinela; Aulitzky, Walter E.; Hohenberger, Peter; Kroiss, Matthias; Schirmacher, Peter; Schlenk, Richard F.; Keilholz, Ulrich; Klauschen, Frederick; Folprecht, Gunnar; Bauer, Sebastian; Siveke, Jens; Brandts, Christian H.; Kindler, Thomas; Boerries, Melanie; Illert, Anna L.; von Bubnoff, Nikolas; Jost, Philipp J.; Spiekermann, Karsten; Bitzer, Michael; Schulze-Osthoff, Klaus; von Kalle, Christof; Klink, Barbara; Brors, Benedikt; Stenzinger, Albrecht; Schröck, Evelin; Hübschmann, Daniel; Weichert, Wilko; Glimm, Hanno; Fröhling, Stefan
    Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers
    In: Cancer Discovery Vol. 11 (2021) Nr. 11, pp. 2780 - 2795
    Online Full Text: dx.doi.org/ (Open Access)
  • Grunewald, Susanne; Klug, Lillian R.; Mühlenberg, Thomas; Lategahn, Jonas; Falkenhorst, Johanna; Town, Ajia; Ehrt, Christiane; Wardelmann, Eva; Hartmann, Wolfgang; Schildhaus, Hans-Ulrich; Treckmann, Jürgen-Walter; Fletcher, Jonathan A.; Jung, Sascha; Czodrowski, Paul; Miller, Stephen; Schmidt-Kittler, Oleg; Rauh, Daniel; Heinrich, Michael C.; Bauer, Sebastian
    Resistance to avapritinib in pdgfra-driven gist is caused by secondary mutations in the pdgfra kinase domain
    In: Cancer Discovery Vol. 11 (2021) Nr. 1, pp. 108 - 125
    Online Full Text: dx.doi.org/ (Open Access)
  • Gronchi, A.; Miah, A.B.; Dei Tos, A.P.; Abecassis, N.; Bajpai, J.; Bauer, Sebastian; Biagini, R.; Bielack, S.; Blay, J.Y.; Bolle, S.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Boye, K.; Brennan, B.; Brodowicz, T.; Buonadonna, A.; De Álava, E.; Del Muro, X.G.; Dufresne, A.; Eriksson, M.; Fagioli, F.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Frezza, A.M.; Gasperoni, S.; Gelderblom, H.; Gouin, F.; Grignani, G.; Haas, R.; Hassan, A.B.; Hecker-Nolting, S.; Hindi, N.; Hohenberger, P.; Joensuu, H.; Jones, R.L.; Jungels, C.; Jutte, P.; Kager, L.; Kasper, B.; Kawai, A.; Kopeckova, K.; Krákorová, D.A.; Le Cesne, A.; Le Grange, F.; Legius, E.; Leithner, A.; Lopez-Pousa, A.; Martin-Broto, J.; Merimsky, O.; Messiou, C.; Mir, O.; Montemurro, M.; Morland, B.; Morosi, C.; Palmerini, E.; Pantaleo, M.A.; Piana, R.; Piperno-Neumann, S.; Reichardt, P.; Rutkowski, P.; Safwat, A.A.; Sangalli, C.; Sbaraglia, M.; Scheipl, S.; Schöffski, P.; Sleijfer, S.; Strauss, D.; Strauss, S.; Sundby Hall, K.; Trama, A.; Unk, M.; van de Sande, M.A.J.; van der Graaf, W.T.A.; van Houdt, W.J.; Frebourg, T.; Casali, P.G.; Stacchiotti, S.
    Soft tissue and visceral sarcomas : ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆
    In: Annals of Oncology Vol. 32 (2021) Nr. 11, 1348-1365
    Online Full Text: dx.doi.org/ (Open Access)
  • Heinrich, Michael C.; Jones, Robin L.; von Mehren, Margaret; Schöffski, Patrick; Serrano, César; Kang, Yoon-Koo; Cassier, Philippe A.; Mir, Olivier; Eskens, Ferry; Tap, William D.; Rutkowski, Piotr; Chawla, Sant P.; Trent, Jonathan; Tugnait, Meera; Evans, Erica K.; Lauz, Tamieka; Zhou, Teresa; Roche, Maria; Wolf, Beni B.; Bauer, Sebastian; George, Suzanne
    Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR) : A multicentre, open-label, phase 1 trial
    In: The Lancet Oncology Vol. 21 (2020) Nr. 7, pp. 935 - 946
    Online Full Text: dx.doi.org/
  • Blay, Jean-Yves; Serrano, César; Heinrich, Michael C.; Zalcberg, John; Bauer, Sebastian; Gelderblom, Hans; Schöffski, Patrick; Jones, Robin L; Attia, Steven; D'Amato, Gina; Chi, Ping; Reichardt, Peter; Meade, Julie; Shi, Kelvin; Ruiz-Soto, Rodrigo; George, Suzanne; von Mehren, Margaret
    Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS) : a double-blind, randomised, placebo-controlled, phase 3 trial
    In: The Lancet Oncology Vol. 21 (2020) Nr. 7, pp. 923 - 934
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Joensuu, Heikki; Eriksson, Mikael; Sundby Hall, Kirsten; Reichardt, Annette; Hermes, Barbara; Schütte, Jochen; Cameron, Silke; Hohenberger, Peter; Jost, Philipp J.; Al-Batran, Salah-Eddin; Lindner, Lars H.; Bauer, Sebastian; Wardelmann, Eva; Nilsson, Bengt; Kallio, Raija; Jaakkola, Panu; Junnila, Jouni; Alvegård, Thor; Reichardt, Peter
    Survival Outcomes Associated with 3 Years vs 1 Year of Adjuvant Imatinib for Patients with High-Risk Gastrointestinal Stromal Tumors : An Analysis of a Randomized Clinical Trial after 10-Year Follow-up
    In: JAMA Oncology Vol. 6 (2020) Nr. 8, pp. 1241 - 1246
    Online Full Text: dx.doi.org/ (Open Access)
  • Gröschel, Stefan; Hübschmann, Daniel; Raimondi, Francesco; Horak, Peter; Warsow, Gregor; Fröhlich, Martina; Klink, Barbara; Gieldon, Laura; Hutter, Barbara; Kleinheinz, Kortine; Bonekamp, David; Marschal, Oliver; Chudasama, Priya; Mika, Jagoda; Groth, Marie; Uhrig, Sebastian; Krämer, Stephen; Heining, Christoph; Heilig, Christoph E.; Richter, Daniela; Reisinger, Eva; Pfütze, Katrin; Eils, Roland; Wolf, Stephan; Kalle, Christof von; Brandts, Christian; Scholl, Claudia; Weichert, Wilko; Richter, Stephan; Bauer, Sebastian; Penzel, Roland; Schröck, Evelin; Stenzinger, Albrecht; Schlenk, Richard F.; Brors, Benedikt; Russell, Robert B.; Glimm, Hanno; Schlesner, Matthias; Fröhling, Stefan
    Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1635
    Online Full Text: dx.doi.org/ (Open Access)
  • Tap, William D.; Gelderblom, Hans; Palmerini, Emanuela; Desai, Jayesh; Bauer, Sebastian; Blay, Jean-Yves; Alcindor, Thierry; Ganjoo, Kristen; Martín-Broto, Javier; Ryan, Christopher W.; Thomas, David M.; Peterfy, Charles; Healey, John H.; Sande, Michiel van de; Gelhorn, Heather L.; Shuster, Dale E.; Wang, Qiang; Yver, Antoine; Hsu, Henry H.; Lin, Paul S.; Tong-Starksen, Sandra; Stacchiotti, Silvia; Wagner, Andrew J.
    Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN) : a randomised phase 3 trial
    In: Lancet Vol. 394 (2019) Nr. 10197, pp. 478 - 487
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Schöffski, Patrick; Wozniak, A.; Kasper, B.; Aamdal, S.; Leahy, M.G.; Rutkowski, P.; Bauer, Sebastian; Gelderblom, H.; Italiano, A.; Lindner, L.H.; Hennig, I.; Strauss, S.; Zakotnik, B.; Anthoney, A.; Albiges, L.; Blay, J.-Y.; Reichardt, P.; Sufliarsky, J.; van der Graaf, W.T.A.; Debiec-Rychter, M.; Sciot, R.; Van Cann, T.; Marréaud, S.; Raveloarivahy, T.; Collette, S.; Stacchiotti, S.
    Activity and safety of crizotinib in patients with alveolar soft part sarcoma with rearrangement of TFE3 : European Organization for Research and Treatment of Cancer (EORTC) phase II trial 90101 'CREATE'
    In: Annals of Oncology Vol. 29 (2018) Nr. 3, pp. 758 - 765
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Casali, P.G.; Bielack, S.; Abecassis, N.; Aro, H.T.; Bauer, Sebastian; Biagini, R.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Brennan, B.; Brodowicz, T.; Broto, J.M.; Brugières, L.; Buonadonna, A.; De Álava, E.; Dei Tos, A.P.; Del Muro, X.G.; Dileo, P.; Dhooge, C.; Eriksson, M.; Fagioli, F.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Ferrari, S.; Frezza, A.M.; Gaspar, N.; Gasperoni, S.; Gelderblom, H.; Gil, T.; Grignani, G.; Gronchi, A.; Haas, R.L.; Hassan, B.; Hecker-Nolting, S.; Hohenberger, P.; Issels, R.; Joensuu, H.; Jones, R.L.; Judson, I.; Jutte, P.; Kaal, S.; Kager, L.; Kasper, B.; Kopeckova, K.; Krákorová, D.A.; Ladenstein, R.; Le Cesne, A.; Lugowska, I.; Merimsky, O.; Montemurro, M.; Morland, B.; Pantaleo, M.A.; Piana, R.; Picci, P.; Piperno-Neumann, S.; Pousa, A.L.; Reichardt, P.; Robinson, M.H.; Rutkowski, P.; Safwat, A.A.; Schöffski, P.; Sleijfer, S.; Stacchiotti, S.; Strauss, S.J.; Sundby Hall, K.; Unk, M.; Van Coevorden, F.; Van Der Graaf, W.T.A.; Whelan, J.; Wardelmann, E.; Zaikova, O.; Blay, J.Y.
    Bone sarcomas : ESMO-PaedCan-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
    In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 4, pp. iv79 - iv95
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • George, Suzanne; Bauer, Sebastian; Jones, Robin L.; Serrano, Christina S.; Mehren, Margaret M. von; Kang, Y.-K.; Schöffski, Patrick; Cassier, Philippe A.; Eskens, Ferry A.; Mir, Olivier; Tap, William D.; Chawla, Sant P.; Rutkowski, Piotr; Shi, H.; Schmidt-Kittler, Oleg; Mar, B.; Heinrich, Michael
    Correlation of ctDNA and response in patients (pts) with PDGFRα D842 GIST treated with avapritinib
    In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii584
    Online Full Text: dx.doi.org/ (Open Access)
  • Casali, P.G.; Abecassis, N.; Bauer, Sebastian; Biagini, R.; Bielack, S.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Brodowicz, T.; Broto, J.M.; Buonadonna, A.; De Álava, E.; Dei Tos, A.P.; Del Muro, X.G.; Dileo, P.; Eriksson, M.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Ferrari, S.; Frezza, A.M.; Gasperoni, S.; Gelderblom, H.; Gil, T.; Grignani, G.; Gronchi, A.; Haas, R.L.; Hannu, A.; Hassan, B.; Hohenberger, P.; Issels, R.; Joensuu, H.; Jones, R.L.; Judson, I.; Jutte, P.; Kaal, S.; Kasper, B.; Kopeckova, K.; Krákorová, D.A.; Le Cesne, A.; Lugowska, I.; Merimsky, O.; Montemurro, M.; Pantaleo, M.A.; Piana, R.; Picci, P.; Piperno-Neumann, S.; Pousa, A.L.; Reichardt, P.; Robinson, M.H.; Rutkowski, P.; Safwat, A.A.; Schöffski, P.; Sleijfer, S.; Stacchiotti, S.; Sundby Hall, K.; Unk, M.; Van Coevorden, F.; Van Der Graaf, W.; Whelan, J.; Wardelmann, E.; Zaikova, O.; Blay, J.Y.
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    Online Full Text: dx.doi.org/ (Open Access)
  • Grünwald, Viktor; Schuler, Martin H.; Schöffski, Patrick; Kopp, Hans-Georg; Bauer, Sebastian; Kasper, Bernd; Lindner, Lars H.; Chemnitz, Jens M.; Crysandt, Martina; Stein, Alexander; Steffen, B.; Richter, Stephan; Kneba, Michael; Egerer, Gerlinde; Zimmermann, S.; Karch, Annika; Kunitz, Annegret
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    In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii577
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  • Chudasama, Priya; Mughal, Sadaf S.; Schröck, Evelin; Glimm, Hanno; Kleinheinz, Kortine; Klink, Barbara; Brors, Benedikt; Hlevnjak, Mario; Gröschel, Stefan; Wolf, Stephan; Omlor, Georg; Ernst, Aurélie; Ulrich, Alexis; Deeg, Katharina I.; Mechtersheimer, Gunhild; Schimmack, Simon; Eils, Roland; Egerer, Gerlinde; Kasper, Bernd; Wong, Siao-Han; von Kalle, Christof; Hohenberger, Peter; Lehner, Burkhard; Rippe, Karsten; Chung, Inn; Bauer, Sebastian; Scholl, Claudia; Sieverling, Lina; Sanders, Mathijs A.; Hübschmann, Daniel; Heilig, Christoph E.; Hutter, Barbara; Renner, Marcus; Weichert, Wilko; Stenzinger, Albrecht; Schlesner, Matthias; Hoogenboezem, Remco M.; Kopp, Hans-Georg; Rabe, Sophie; Zapatka, Marc; Fröhling, Stefan
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    Online Full Text: dx.doi.org/ (Open Access)
  • Casali, P.G.; Abecassis, N.; Bauer, Sebastian; Biagini, R.; Bielack, S.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Brodowicz, T.; Broto, J.M.; Buonadonna, A.; De Álava, E.; Dei Tos, A.P.; Del Muro, X.G.; Dileo, P.; Eriksson, M.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Ferrari, S.; Frezza, A.M.; Gasperoni, S.; Gelderblom, H.; Gil, T.; Grignani, G.; Gronchi, A.; Haas, R.L.; Hannu, A.; Hassan, B.; Hohenberger, P.; Issels, R.; Joensuu, H.; Jones, R.L.; Judson, I.; Jutte, P.; Kaal, S.; Kasper, B.; Kopeckova, K.; Krákorová, D.A.; Le Cesne, A.; Lugowska, I.; Merimsky, O.; Montemurro, M.; Pantaleo, M.A.; Piana, R.; Picci, P.; Piperno-Neumann, S.; Pousa, A.L.; Reichardt, P.; Robinson, M.H.; Rutkowski, P.; Safwat, A.A.; Schöffski, P.; Sleijfer, S.; Stacchiotti, S.; Sundby Hall, K.; Unk, M.; Van Coevorden, F.; Van Der Graaf, W.; Whelan, J.; Wardelmann, E.; Zaikova, O.; Blay, J.Y.
    Soft tissue and visceral sarcomas : ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
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    Online Full Text: dx.doi.org/ (Open Access)
  • Hemming, M L; Heinrich, M C; Bauer, Sebastian; George, S
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    Online Full Text: dx.doi.org/ (Open Access)
  • Bauer, Sebastian; George, Suzanne; Kang, Y.-K.; Tap, William D.; Zhou, T.; Picazio, N.; Boral, Andy L.; Heinrich, Michael
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    In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii595
    Online Full Text: dx.doi.org/ (Open Access)
  • Wagner, Andrew J.; Kindler, Hedy Lee; Gelderblom, Hans J.; Schöffski, Patrick; Bauer, Sebastian; Hohenberger, Peter; Kopp, Hans Georg; Lopez-Martin, José Antonio; Peeters, Marc A.; Reichardt, Peter; Qin, Amy; Nippgen, Johannes B.W.; Ilaria, Robert L.; Rutkowski, Piotr L.
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    Online Full Text: dx.doi.org/ (Open Access)
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    Effect of KIT and PDGFRA mutations on survival in patients with gastrointestinal stromal tumors treated with adjuvant imatinib : An exploratory analysis of a randomized clinical trial
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    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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  • Kim, Won Kyu; Yun, SeongJu; Park, Cheol Keun; Bauer, Sebastian; Kim, Jiyoon; Lee, Min Goo; Kim, Hoguen
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  • Kasper, B; Sleijfer, S; Litière, S; Marreaud, S; Verweij, J; Hodge, R A; Bauer, Sebastian; Kerst, J M; van der Graaf, W T A
    Long-term responders and survivors on pazopanib for advanced soft tissue sarcomas : subanalysis of two European Organisation for Research and Treatment of Cancer (EORTC) clinical trials 62043 and 62072
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    Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients
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  • Mühlenberg, T.; Grunewald, S.; Schuler, Martin; Bauer, Sebastian
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    DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
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  • Demetri, G. D.; Jeffers, M.; Reichardt, P.; Kang, Y. K.; Blay, J. Y.; Rutkowski, P.; Gelderblom, H.; Hohenberger, P.; Leahy, M.; von Mehren, M.; Joensuu, H.; Badalamenti, G.; Blackstein, M.; Le Cesne, A.; Schoffski, P.; Maki, R. G.; Bauer, Sebastian; Nguyen, B. B.; Xu, J. M.; Nishida, T.; Chung, J.; Lathia, C. D.; Kappeler, C.; Kuss, I.; Laurent, D.; Casali, P. G.
    Detection of oncogenic kinase mutations in circulating plasma DNA and correlation with clinical benefit in the phase III GRID study of regorafenib vs placebo in TKI-refractory metastatic GIST
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    Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID) : an international, multicentre, randomised, placebo-controlled, phase 3 trial
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    Neoadjuvant Imatinib in Locally Advanced Gastrointestinal Stromal Tumors (GIST) : The EORTC STBSG Experience
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    Online Full Text: dx.doi.org/
  • Joensuu, H.; Eriksson, M.; Sundby Hall, K.; Hartmann, J. T.; Pink, D.; Schütte, Jochen; Ramadori, G.; Hohenberger, P.; Duyster, J.; Al-Batran, S. E.; Schlemmer, M.; Bauer, Sebastian; Wardelmann, E.; Sarlomo-Rikala, M.; Nilsson, B.; Sihto, H.; Monge, O. R.; Bono, P.; Kallio, R.; Vehtari, A.; Leinonen, M.; Alvegård, T.; Reichardt, P.
    One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor : a randomized trial
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    Online Full Text: dx.doi.org/
  • Grabellus, Florian; Kraft, Corinna; Sheu, Sien-Yi; Ebeling, Peter; Bauer, Sebastian; Lendemans, Sven; Schmid, Kurt Werner; Täger, Georg
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    In: Annals of Surgical Oncology Vol. 16 (2009) Nr. 3, pp. 676 - 686
    Online Full Text: dx.doi.org/
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    Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors
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    Online Full Text: dx.doi.org/ (Open Access)
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