ZMB Member Sebastian Bauer

ZMB Member
Sebastian Bauer

Next ZMB-Member
Sebastian Bauer
© UKE/S.Bauer

Prof. Dr. Sebastian Bauer

West German Cancer Center (WTZ)
University Hospital Essen
Hufelandstr. 55
45147 Essen

Research Overview

  1. Analysis of oncogenetic signalling pathways in soft-tissue sarcoma (esp. GIST)
  2. Evaluation of purposive, small molecular inhibitors of tyrosine kinases in soft-tissue sarcoma
  3. Development of soft-tissue sarcoma models (cell lines and Xenografts)
  4. Evaluation of preclinical diagnostic techniques/methods (in vitro/in vivo) for GIST and other soft-tissue sarcoma
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Selected Publications

    Journal articles

  • Vincenzi, Bruno; Napolitano, Andrea; Fiocco, Marta; Mir, Olivier; Rutkowski, Piotr; Blay, Jean-Yves; Reichardt, Peter; Joensuu, Heikki; Fumagalli, Elena; Gennatas, Spyridon; Hindi, Nadia; Nannini, Margherita; Ceruso, Mariella Spalato; Italiano, Antoine; Grignani, Giovanni; Brunello, Antonella; Gasperoni, Silvia; De Pas, Tommaso; Badalamenti, Giuseppe; Pantaleo, Maria A.; Van Houdt, Winan J.; IJzerman, Nikki S.; Steeghs, Neeltje; Gelderblom, Hans; Desar, Ingrid M.E.; Falkenhorst, Johanna; Silletta, Marianna; Sbaraglia, Marta; Tonini, Giuseppe; Martin-Brot, Javier; Hohenberger, Peter; Le Cesne, Axel; Jones, Robin L.; Dei Tos, Angelo P.; Gronchi, Alessandro; Bauer, Sebastian; Casali, Paolo G.
    Adjuvant Imatinib in Patients with GIST Harboring Exon 9 KIT Mutations : Results from a Multi-institutional European Retrospective Study
    In: Clinical Cancer Research Vol. 28 (2022) Nr. 8, pp. 1672 - 1679
    ISSN: 1557-3265; 1078-0432
  • Casali, P. G.; Blay, J. Y.; Bauer, Sebastian; Stacchiotti, S.; et al.
    Gastrointestinal stromal tumours : ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up
    In: Annals of Oncology Vol. 33 (2022) Nr. 1, pp. 20 - 33
    ISSN: 1569-8041; 0923-7534
  • Stork, Theresa; Hegedüs, Balazs; Guder, Wiebke; Hamacher, Rainer; Hardes, Jendrik; Kaths, Moritz; Plönes, Till; Pöttgen, Christoph; Schildhaus, Hans-Ulrich; Streitbürger, Arne; Treckmann, Juergen; Bauer, Sebastian; Aigner, Clemens; Collaud, Stéphane
    Prognostic Factors for Leiomyosarcoma with Isolated Metastases to the Lungs : Impact of Metastasectomy
    In: Annals of Surgical Oncology Vol. 29 (2022) Nr. 7, pp. 4429 - 4436
    ISSN: 1068-9265; 1534-4681
  • Stein, Eytan M.; DeAngelo, Daniel J.; Chromik, Jörg; Chatterjee, Manik; Bauer, Sebastian; Lin, Chia-Chi; Suarez, Cristina; de Vos, Filip; Steeghs, Neeltje; Cassier, Philippe A.; Tai, David; Kiladjian, Jean-Jacques; Yamamoto, Noboru; Mous, Rogier; Esteve, Jordi; Minami, Hironobu; Ferretti, Stephane; Guerreiro, Nelson; Meille, Christophe; Radhakrishnan, Rajkumar; Pereira, Bernard; Mariconti, Luisa; Halilovic, Ensar; Fabre, Claire; Carpio, Cecilia; Cassier, Phillippe A.
    Results from a First-in-Human Phase I Study of Siremadlin (HDM201) in Patients with Advanced Wild-Type TP53 Solid Tumors and Acute Leukemia
    In: Clinical Cancer Research Vol. 28 (2022) Nr. 5, pp. 870 - 881
    ISSN: 1557-3265; 1078-0432
  • Strauss, S.J.; Frezza, A.M.; Abecassis, N.; Bajpai, J.; Bauer, Sebastian; Biagini, R.; Bielack, S.; Blay, J.Y.; Bolle, S.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Boye, K.; Brennan, B.; Brodowicz, T.; Buonadonna, A.; de Álava, E.; Dei Tos, A.P.; Garcia del Muro, X.; Dufresne, A.; Eriksson, M.; Fagioli, F.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Gaspar, N.; Gasperoni, S.; Gelderblom, H.; Gouin, F.; Grignani, G.; Gronchi, A.; Haas, R.; Hassan, A.B.; Hecker-Nolting, S.; Hindi, N.; Hohenberger, P.; Joensuu, H.; Jones, R.L.; Jungels, C.; Jutte, P.; Kager, L.; Kasper, B.; Kawai, A.; Kopeckova, K.; Krákorová, D.A.; Le Cesne, A.; Le Grange, F.; Legius, E.; Leithner, A.; López Pousa, A.; Martin-Broto, J.; Merimsky, O.; Messiou, C.; Miah, A.B.; Mir, O.; Montemurro, M.; Morland, B.; Morosi, C.; Palmerini, E.; Pantaleo, M.A.; Piana, R.; Piperno-Neumann, S.; Reichardt, P.; Rutkowski, P.; Safwat, A.A.; Sangalli, C.; Sbaraglia, M.; Scheipl, S.; Schöffski, P.; Sleijfer, S.; Strauss, D.; Sundby Hall, K.; Trama, A.; Unk, M.; van de Sande, M.A.J.; van der Graaf, W.T.A.; van Houdt, W.J.; Frebourg, T.; Ladenstein, R.; Casali, P.G.; Stacchiotti, S.
    Bone sarcomas : ESMO–EURACAN–GENTURIS–ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up
    In: Annals of oncology Vol. 32 (2021) Nr. 12, pp. 1520 - 1536
    ISSN: 0923-7534; 1569-8041
  • Bauer, Sebastian; Heinrich, Michael C.; George, Suzanne; Zalcberg, John R.; Serrano, César; Gelderblom, Hans; Jones, Robin L.; Attia, Steven; D'Amato, Gina; Chi, Ping; Reichardt, Peter; Meade, Julie; Su, Ying; Ruiz-Soto, Rodrigo; Blay, Jean-Yves; von Mehren, Margaret; Schöffski, Patrick
    Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study
    In: Clinical Cancer Research Vol. 27 (2021) Nr. 23, pp. 6333 - 6342
    ISSN: 1557-3265; 1078-0432
  • Horak, Peter; Heining, Christoph; Kreutzfeldt, Simon; Hutter, Barbara; Mock, Andreas; Hüllein, Jennifer; Fröhlich, Martina; Uhrig, Sebastian; Jahn, Arne; Rump, Andreas; Gieldon, Laura; Möhrmann, Lino; Hanf, Dorothea; Teleanu, Veronica; Heilig, Christoph E.; Lipka, Daniel B.; Allgäuer, Michael; Ruhnke, Leo; Laßmann, Andreas; Endris, Volker; Neumann, Olaf; Penzel, Roland; Beck, Katja; Richter, Daniela; Winter, Ulrike; Wolf, Stephan; Pfütze, Katrin; Geörg, Christina; Meißburger, Bettina; Buchhalter, Ivo; Augustin, Marinela; Aulitzky, Walter E.; Hohenberger, Peter; Kroiss, Matthias; Schirmacher, Peter; Schlenk, Richard F.; Keilholz, Ulrich; Klauschen, Frederick; Folprecht, Gunnar; Bauer, Sebastian; Siveke, Jens; Brandts, Christian H.; Kindler, Thomas; Boerries, Melanie; Illert, Anna L.; von Bubnoff, Nikolas; Jost, Philipp J.; Spiekermann, Karsten; Bitzer, Michael; Schulze-Osthoff, Klaus; von Kalle, Christof; Klink, Barbara; Brors, Benedikt; Stenzinger, Albrecht; Schröck, Evelin; Hübschmann, Daniel; Weichert, Wilko; Glimm, Hanno; Fröhling, Stefan
    Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers
    In: Cancer Discovery Vol. 11 (2021) Nr. 11, pp. 2780 - 2795
    ISSN: 2159-8290; 2159-8274
  • Grunewald, Susanne; Klug, Lillian R.; Mühlenberg, Thomas; Lategahn, Jonas; Falkenhorst, Johanna; Town, Ajia; Ehrt, Christiane; Wardelmann, Eva; Hartmann, Wolfgang; Schildhaus, Hans-Ulrich; Treckmann, Jürgen-Walter; Fletcher, Jonathan A.; Jung, Sascha; Czodrowski, Paul; Miller, Stephen; Schmidt-Kittler, Oleg; Rauh, Daniel; Heinrich, Michael C.; Bauer, Sebastian
    Resistance to avapritinib in pdgfra-driven gist is caused by secondary mutations in the pdgfra kinase domain
    In: Cancer Discovery Vol. 11 (2021) Nr. 1, pp. 108 - 125
    ISSN: 2159-8290; 2159-8274
  • Gronchi, A.; Miah, A.B.; Dei Tos, A.P.; Abecassis, N.; Bajpai, J.; Bauer, Sebastian; Biagini, R.; Bielack, S.; Blay, J.Y.; Bolle, S.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Boye, K.; Brennan, B.; Brodowicz, T.; Buonadonna, A.; De Álava, E.; Del Muro, X.G.; Dufresne, A.; Eriksson, M.; Fagioli, F.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Frezza, A.M.; Gasperoni, S.; Gelderblom, H.; Gouin, F.; Grignani, G.; Haas, R.; Hassan, A.B.; Hecker-Nolting, S.; Hindi, N.; Hohenberger, P.; Joensuu, H.; Jones, R.L.; Jungels, C.; Jutte, P.; Kager, L.; Kasper, B.; Kawai, A.; Kopeckova, K.; Krákorová, D.A.; Le Cesne, A.; Le Grange, F.; Legius, E.; Leithner, A.; Lopez-Pousa, A.; Martin-Broto, J.; Merimsky, O.; Messiou, C.; Mir, O.; Montemurro, M.; Morland, B.; Morosi, C.; Palmerini, E.; Pantaleo, M.A.; Piana, R.; Piperno-Neumann, S.; Reichardt, P.; Rutkowski, P.; Safwat, A.A.; Sangalli, C.; Sbaraglia, M.; Scheipl, S.; Schöffski, P.; Sleijfer, S.; Strauss, D.; Strauss, S.; Sundby Hall, K.; Trama, A.; Unk, M.; van de Sande, M.A.J.; van der Graaf, W.T.A.; van Houdt, W.J.; Frebourg, T.; Casali, P.G.; Stacchiotti, S.
    Soft tissue and visceral sarcomas : ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆
    In: Annals of Oncology Vol. 32 (2021) Nr. 11,
    ISSN: 1569-8041; 0923-7534
  • Heinrich, Michael C.; Jones, Robin L.; von Mehren, Margaret; Schöffski, Patrick; Serrano, César; Kang, Yoon-Koo; Cassier, Philippe A.; Mir, Olivier; Eskens, Ferry; Tap, William D.; Rutkowski, Piotr; Chawla, Sant P.; Trent, Jonathan; Tugnait, Meera; Evans, Erica K.; Lauz, Tamieka; Zhou, Teresa; Roche, Maria; Wolf, Beni B.; Bauer, Sebastian; George, Suzanne
    Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR) : A multicentre, open-label, phase 1 trial
    In: The Lancet Oncology Vol. 21 (2020) Nr. 7, pp. 935 - 946
    ISSN: 1474-5488; 1470-2045
  • Heinrich, Michael C.; George, Suzanne; Zalcberg, John Raymond; Bauer, Sebastian; Gelderblom, Hans; Schoffski, Patrick; Serrano, Cesar; Jones, Robin L.; Attia, Steven; D'Amato, Gina Z.; Chi, Ping; Reichardt, Peter; Becker, Claus C.; Meade, Julie Nicole; Ruiz-Soto, Rodrigo; von Mehren, Margaret; Blay, Jean-Yves
    Quality of life (QoL) and self-reported function with ripretinib in ≥4th-line therapy for patients with gastrointestinal stromal tumors (GIST) : Analyses from INVICTUS
    In: Journal of Clinical Oncology Vol. 38 (2020) Nr. 15_Suppl., pp. 11535
    ISSN: 0732-183X; 1527-7755
  • Grünwald, Viktor; Karch, Annika; Schuler, Markus; Schöffski, Patrick; Kopp, Hans-Georg; Bauer, Sebastian; Kasper, Bernd; Lindner, Lars H.; Chemnitz, Jens-Marcus; Crysandt, Martina; Stein, Alexander; Steffen, Björn; Richter, Stephan; Egerer, Gerlinde; Ivanyi, Philipp; Zimmermann, Silke; Liu, Xiaofei; Kunitz, Annegret
    Randomized Comparison of Pazopanib and Doxorubicin as First-Line Treatment in Patients with Metastatic Soft Tissue Sarcoma Age 60 Years or Older : Results of a German Intergroup Study
    In: Journal of Clinical Oncology Vol. 38 (2020) Nr. 30, pp. 3555 - 3564
    ISSN: 1527-7755; 0732-183X
  • Blay, Jean-Yves; Serrano, César; Heinrich, Michael C.; Zalcberg, John; Bauer, Sebastian; Gelderblom, Hans; Schöffski, Patrick; Jones, Robin L; Attia, Steven; D'Amato, Gina; Chi, Ping; Reichardt, Peter; Meade, Julie; Shi, Kelvin; Ruiz-Soto, Rodrigo; George, Suzanne; von Mehren, Margaret
    Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS) : a double-blind, randomised, placebo-controlled, phase 3 trial
    In: The Lancet Oncology Vol. 21 (2020) Nr. 7, pp. 923 - 934
    ISSN: 1474-5488; 1470-2045
  • George, Suzanne; Heinrich, Michael C.; Zalcberg, John Raymond; Bauer, Sebastian; Gelderblom, Hans; Schoffski, Patrick; Serrano, Cesar; Jones, Robin L.; Attia, Steven; D'Amato, Gina Z.; Chi, Ping; Reichardt, Peter; Lacouture, Mario E.; Cha, Elva; Meade, Julie Nicole; Ruiz-Soto, Rodrigo; Blay, Jean-Yves; von Mehren, Margaret
    Safety profile of ripretinib, including impact of alopecia, and Palmar-Plantar Erythrodysesthesia Syndrome (PPES) on patient-reported outcomes (PROs), in ≥ fourth-line advanced gastrointestinal stromal tumors (GIST) : Analyses from INVICTUS
    In: Journal of Clinical Oncology Vol. 38 (2020) Nr. 15_Suppl., pp. 11539
    ISSN: 0732-183X; 1527-7755
  • Joensuu, Heikki; Eriksson, Mikael; Sundby Hall, Kirsten; Reichardt, Annette; Hermes, Barbara; Schütte, Jochen; Cameron, Silke; Hohenberger, Peter; Jost, Philipp J.; Al-Batran, Salah-Eddin; Lindner, Lars H.; Bauer, Sebastian; Wardelmann, Eva; Nilsson, Bengt; Kallio, Raija; Jaakkola, Panu; Junnila, Jouni; Alvegård, Thor; Reichardt, Peter
    Survival Outcomes Associated with 3 Years vs 1 Year of Adjuvant Imatinib for Patients with High-Risk Gastrointestinal Stromal Tumors : An Analysis of a Randomized Clinical Trial after 10-Year Follow-up
    In: JAMA Oncology Vol. 6 (2020) Nr. 8, pp. 1241 - 1246
    ISSN: 2374-2445; 2374-2437
  • Gröschel, Stefan; Hübschmann, Daniel; Raimondi, Francesco; Horak, Peter; Warsow, Gregor; Fröhlich, Martina; Klink, Barbara; Gieldon, Laura; Hutter, Barbara; Kleinheinz, Kortine; Bonekamp, David; Marschal, Oliver; Chudasama, Priya; Mika, Jagoda; Groth, Marie; Uhrig, Sebastian; Krämer, Stephen; Heining, Christoph; Heilig, Christoph E.; Richter, Daniela; Reisinger, Eva; Pfütze, Katrin; Eils, Roland; Wolf, Stephan; Kalle, Christof von; Brandts, Christian; Scholl, Claudia; Weichert, Wilko; Richter, Stephan; Bauer, Sebastian; Penzel, Roland; Schröck, Evelin; Stenzinger, Albrecht; Schlenk, Richard F.; Brors, Benedikt; Russell, Robert B.; Glimm, Hanno; Schlesner, Matthias; Fröhling, Stefan
    Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1635
    ISSN: 2041-1723
  • Tap, William D.; Gelderblom, Hans; Palmerini, Emanuela; Desai, Jayesh; Bauer, Sebastian; Blay, Jean-Yves; Alcindor, Thierry; Ganjoo, Kristen; Martín-Broto, Javier; Ryan, Christopher W.; Thomas, David M.; Peterfy, Charles; Healey, John H.; Sande, Michiel van de; Gelhorn, Heather L.; Shuster, Dale E.; Wang, Qiang; Yver, Antoine; Hsu, Henry H.; Lin, Paul S.; Tong-Starksen, Sandra; Stacchiotti, Silvia; Wagner, Andrew J.
    Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN) : a randomised phase 3 trial
    In: The Lancet Vol. 394 (2019) Nr. 10197, pp. 478 - 487
    ISSN: 1474-547X; 0140-6736
  • Schöffski, Patrick; Wozniak, A.; Kasper, B.; Aamdal, S.; Leahy, M.G.; Rutkowski, P.; Bauer, Sebastian; Gelderblom, H.; Italiano, A.; Lindner, L.H.; Hennig, I.; Strauss, S.; Zakotnik, B.; Anthoney, A.; Albiges, L.; Blay, J.-Y.; Reichardt, P.; Sufliarsky, J.; van der Graaf, W.T.A.; Debiec-Rychter, M.; Sciot, R.; Van Cann, T.; Marréaud, S.; Raveloarivahy, T.; Collette, S.; Stacchiotti, S.
    Activity and safety of crizotinib in patients with alveolar soft part sarcoma with rearrangement of TFE3 : European Organization for Research and Treatment of Cancer (EORTC) phase II trial 90101 'CREATE'
    In: Annals of Oncology Vol. 29 (2018) Nr. 3, pp. 758 - 765
    ISSN: 1569-8041; 0923-7534
  • Casali, P.G.; Bielack, S.; Abecassis, N.; Aro, H.T.; Bauer, Sebastian; Biagini, R.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Brennan, B.; Brodowicz, T.; Broto, J.M.; Brugières, L.; Buonadonna, A.; De Álava, E.; Dei Tos, A.P.; Del Muro, X.G.; Dileo, P.; Dhooge, C.; Eriksson, M.; Fagioli, F.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Ferrari, S.; Frezza, A.M.; Gaspar, N.; Gasperoni, S.; Gelderblom, H.; Gil, T.; Grignani, G.; Gronchi, A.; Haas, R.L.; Hassan, B.; Hecker-Nolting, S.; Hohenberger, P.; Issels, R.; Joensuu, H.; Jones, R.L.; Judson, I.; Jutte, P.; Kaal, S.; Kager, L.; Kasper, B.; Kopeckova, K.; Krákorová, D.A.; Ladenstein, R.; Le Cesne, A.; Lugowska, I.; Merimsky, O.; Montemurro, M.; Morland, B.; Pantaleo, M.A.; Piana, R.; Picci, P.; Piperno-Neumann, S.; Pousa, A.L.; Reichardt, P.; Robinson, M.H.; Rutkowski, P.; Safwat, A.A.; Schöffski, P.; Sleijfer, S.; Stacchiotti, S.; Strauss, S.J.; Sundby Hall, K.; Unk, M.; Van Coevorden, F.; Van Der Graaf, W.T.A.; Whelan, J.; Wardelmann, E.; Zaikova, O.; Blay, J.Y.
    Bone sarcomas : ESMO-PaedCan-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
    In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 4, pp. iv79 - iv95
    ISSN: 0923-7534
  • George, Suzanne; Bauer, Sebastian; Jones, Robin L.; Serrano, Christina S.; Mehren, Margaret M. von; Kang, Y.-K.; Schöffski, Patrick; Cassier, Philippe A.; Eskens, Ferry A.; Mir, Olivier; Tap, William D.; Chawla, Sant P.; Rutkowski, Piotr; Shi, H.; Schmidt-Kittler, Oleg; Mar, B.; Heinrich, Michael
    Correlation of ctDNA and response in patients (pts) with PDGFRα D842 GIST treated with avapritinib
    In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii584
    ISSN: 0923-7534; 1569-8041
  • Casali, P.G.; Abecassis, N.; Bauer, Sebastian; Biagini, R.; Bielack, S.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Brodowicz, T.; Broto, J.M.; Buonadonna, A.; De Álava, E.; Dei Tos, A.P.; Del Muro, X.G.; Dileo, P.; Eriksson, M.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Ferrari, S.; Frezza, A.M.; Gasperoni, S.; Gelderblom, H.; Gil, T.; Grignani, G.; Gronchi, A.; Haas, R.L.; Hannu, A.; Hassan, B.; Hohenberger, P.; Issels, R.; Joensuu, H.; Jones, R.L.; Judson, I.; Jutte, P.; Kaal, S.; Kasper, B.; Kopeckova, K.; Krákorová, D.A.; Le Cesne, A.; Lugowska, I.; Merimsky, O.; Montemurro, M.; Pantaleo, M.A.; Piana, R.; Picci, P.; Piperno-Neumann, S.; Pousa, A.L.; Reichardt, P.; Robinson, M.H.; Rutkowski, P.; Safwat, A.A.; Schöffski, P.; Sleijfer, S.; Stacchiotti, S.; Sundby Hall, K.; Unk, M.; Van Coevorden, F.; Van Der Graaf, W.; Whelan, J.; Wardelmann, E.; Zaikova, O.; Blay, J.Y.
    Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
    In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 4, pp. iv68 - iv78
    ISSN: 0923-7534; 0923-7534
  • Grünwald, Viktor; Schuler, Martin H.; Schöffski, Patrick; Kopp, Hans-Georg; Bauer, Sebastian; Kasper, Bernd; Lindner, Lars H.; Chemnitz, Jens M.; Crysandt, Martina; Stein, Alexander; Steffen, B.; Richter, Stephan; Kneba, Michael; Egerer, Gerlinde; Zimmermann, S.; Karch, Annika; Kunitz, Annegret
    Health-related quality of life (HR-QoL) in elderly soft tissue sarcoma (STS) patients from the randomized phase II EPAZ study comparing pazopanib (PAZ) and doxorubicin (DOX) in first line
    In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii577
    ISSN: 0923-7534; 1569-8041
  • Chudasama, Priya; Mughal, Sadaf S.; Schröck, Evelin; Glimm, Hanno; Kleinheinz, Kortine; Klink, Barbara; Brors, Benedikt; Hlevnjak, Mario; Gröschel, Stefan; Wolf, Stephan; Omlor, Georg; Ernst, Aurélie; Ulrich, Alexis; Deeg, Katharina I.; Mechtersheimer, Gunhild; Schimmack, Simon; Eils, Roland; Egerer, Gerlinde; Kasper, Bernd; Wong, Siao-Han; von Kalle, Christof; Hohenberger, Peter; Lehner, Burkhard; Rippe, Karsten; Chung, Inn; Bauer, Sebastian; Scholl, Claudia; Sieverling, Lina; Sanders, Mathijs A.; Hübschmann, Daniel; Heilig, Christoph E.; Hutter, Barbara; Renner, Marcus; Weichert, Wilko; Stenzinger, Albrecht; Schlesner, Matthias; Hoogenboezem, Remco M.; Kopp, Hans-Georg; Rabe, Sophie; Zapatka, Marc; Fröhling, Stefan
    Integrative genomic and transcriptomic analysis of leiomyosarcoma
    In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 144
    ISSN: 2041-1723
  • Casali, P.G.; Abecassis, N.; Bauer, Sebastian; Biagini, R.; Bielack, S.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Brodowicz, T.; Broto, J.M.; Buonadonna, A.; De Álava, E.; Dei Tos, A.P.; Del Muro, X.G.; Dileo, P.; Eriksson, M.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Ferrari, S.; Frezza, A.M.; Gasperoni, S.; Gelderblom, H.; Gil, T.; Grignani, G.; Gronchi, A.; Haas, R.L.; Hannu, A.; Hassan, B.; Hohenberger, P.; Issels, R.; Joensuu, H.; Jones, R.L.; Judson, I.; Jutte, P.; Kaal, S.; Kasper, B.; Kopeckova, K.; Krákorová, D.A.; Le Cesne, A.; Lugowska, I.; Merimsky, O.; Montemurro, M.; Pantaleo, M.A.; Piana, R.; Picci, P.; Piperno-Neumann, S.; Pousa, A.L.; Reichardt, P.; Robinson, M.H.; Rutkowski, P.; Safwat, A.A.; Schöffski, P.; Sleijfer, S.; Stacchiotti, S.; Sundby Hall, K.; Unk, M.; Van Coevorden, F.; Van Der Graaf, W.; Whelan, J.; Wardelmann, E.; Zaikova, O.; Blay, J.Y.
    Soft tissue and visceral sarcomas : ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
    In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 4, pp. iv51 - iv67
    ISSN: 1569-8041; 0923-7534
  • Hemming, M L; Heinrich, M C; Bauer, Sebastian; George, S
    Translational Insights into Gastrointestinal Stromal Tumor and Current Clinical Advances
    In: Annals of Oncology Vol. 29 (2018) Nr. 10, pp. 2037 - 2045
    ISSN: 0923-7534; 1569-8041
  • Bauer, Sebastian; George, Suzanne; Kang, Y.-K.; Tap, William D.; Zhou, T.; Picazio, N.; Boral, Andy L.; Heinrich, Michael
    VOYAGER : An open-label, randomised, phase III study of avapritinib vs regorafenib in patients (pts) with locally advanced (adv) metastatic or unresectable gastrointestinal stromal tumour (GIST)
    In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii595
    ISSN: 0923-7534; 1569-8041
  • Wagner, Andrew J.; Kindler, Hedy Lee; Gelderblom, Hans J.; Schöffski, Patrick; Bauer, Sebastian; Hohenberger, Peter; Kopp, Hans Georg; Lopez-Martin, José Antonio; Peeters, Marc A.; Reichardt, Peter; Qin, Amy; Nippgen, Johannes B.W.; Ilaria, Robert L.; Rutkowski, Piotr L.
    A phase II study of a human anti-PDGFRα monoclonal antibody (olaratumab, IMC-3G3) in previously treated patients with metastatic gastrointestinal stromal tumors
    In: Annals of Oncology Vol. 28 (2017) Nr. 3, pp. 541 - 546
    ISSN: 1569-8041; 0923-7534
  • Schöffski, Patrick; Wozniak, A.; Stacchiotti, S.; Rutkowski, P.; Blay, J.-Y.; Lindner, L.H.; Strauss, S.J.; Anthoney, A.; Duffaud, F.; Richter, S.; Grünwald, V.; Leahy, M.G.; Reichardt, P.; Sufliarsky, J.; van der Graaf, W.T.; Sciot, R.; Debiec-Rychter, M.; Van Cann, T.; Marréaud, S.; Lia, M.; Raveloarivahy, T.; Collette, L.; Bauer, Sebastian
    Activity and safety of crizotinib in patients with advanced clear-cell sarcoma with MET alterations : European Organization for Research and Treatment of Cancer phase II trial 90101 'CREATE'
    In: Annals of Oncology Vol. 28 (2017) Nr. 12, pp. 3000 - 3008
    ISSN: 1569-8041; 0923-7534
  • Joensuu, Heikki; Wardelmann, Eva; Sihto, Harri; Eriksson, Mikael; Sundby Hall, Kirsten; Reichardt, Annette; Hartmann, Jörg T.; Pink, Daniel; Cameron, Silke; Hohenberger, Peter; Al-Batran, Salah-Eddin; Schlemmer, Marcus; Bauer, Sebastian; Nilsson, Bengt; Kallio, Raija; Junnila, Jouni; Vehtari, Aki; Reichardt, Peter
    Effect of KIT and PDGFRA mutations on survival in patients with gastrointestinal stromal tumors treated with adjuvant imatinib : An exploratory analysis of a randomized clinical trial
    In: JAMA Oncology Vol. 3 (2017) Nr. 5, pp. 602 - 609
    ISSN: 2374-2445; 2374-2437
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    MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation
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    Sustained mutant KIT activation in the Golgi complex is mediated by PKC-θ in gastrointestinal stromal tumors
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    1401PD - Subgroup analysis of leiomyosarcoma (LMS) patients (pts) from a phase 3, open-label, randomized study of eribulin (ERI) versus dacarbazine (DTIC) in pts with advanced liposarcoma (LPS) and LMS
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  • Dummer, R.; Meille, C.; Demetri, G.; Van Bree, L.; Wuerthner, J.U.; Guerreiro, N.; Jeay, S.; Kumar, A.; Cassier, P.; Bauer, Sebastian; Tan, D.S.; Halilovic, E.
    A phase I, open-label, multi-center, dose escalation study of oral NVP-CGM097, a p53/HDM2-protein-protein interaction inhibitor, in adult patients with selected advanced solid tumors
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  • Kasper, Bernd; Gruenwald, Viktor; Reichardt, Peter; Bauer, Sebastian; Hohenberger, Peter; Haller, Florian
    Correlation of CTNNB1 Mutation Status with Progression Arrest Rate in RECIST Progressive Desmoid-Type Fibromatosis Treated with Imatinib : Translational Research Results from a Phase 2 Study of the German Interdisciplinary Sarcoma Group (GISG-01)
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    Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma : a randomised, open-label, multicentre, phase 3 trial
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    Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR
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    ISSN: 0570-0833; 1521-3773
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    Covalent-Allosteric Kinase Inhibitors
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  • Kasper, B; Sleijfer, S; Litière, S; Marreaud, S; Verweij, J; Hodge, R A; Bauer, Sebastian; Kerst, J M; van der Graaf, W T A
    Long-term responders and survivors on pazopanib for advanced soft tissue sarcomas : subanalysis of two European Organisation for Research and Treatment of Cancer (EORTC) clinical trials 62043 and 62072
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    Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients
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    ISSN: 1078-0432; 1557-3265
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    Targeting glucose metabolism by 2-deoxyglucose in gastrointestinal stromal tumors
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    DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
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    Detection of oncogenic kinase mutations in circulating plasma DNA and correlation with clinical benefit in the phase III GRID study of regorafenib vs placebo in TKI-refractory metastatic GIST
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    Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID) : an international, multicentre, randomised, placebo-controlled, phase 3 trial
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    Neoadjuvant Imatinib in Locally Advanced Gastrointestinal Stromal Tumors (GIST) : The EORTC STBSG Experience
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    One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor : a randomized trial
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    Evaluation of 47 soft tissue sarcoma resection specimens after isolated limb perfusion with TNF-α and melphalan : Histologically characterized improved margins correlate with absence of recurrences
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