ZMB Member Bernd Giebel
ZMB Member
Bernd Giebel
Next ZMB-Member
Prof. Dr. Bernd Giebel
Institute for Transfusion Medicine
University Hospital Essen
Hufelandstraße 55
45122 Essen
- +49 201 723 4204
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- Selected Publications
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- ZMB Research Program
Immunology, Infectious Diseases and Transplantation
Research Overview
The group of Bernd Giebel investigates lineage relationships of early human hematopoietic progenitors as well as mechanisms controlling their self-renewal and lineage specification. In this context the group is especially interested in dissecting roles of asymmetric cell division, which they have proven to occur in at least a proportion of the cells. Since 2009, as a second topic the group is also working in the fast expanding field of extracellular vesicles (EVs), often termed exosomes or microvesicles, respectively. Here, the group is especially interested in deciphering the therapeutic potential of EVs released from mesenchymal stem/stromal cells (MSCs). After demonstrating therapeutic potentials in different systems including the treatment of a graft-versus-host disease patient, the group now aims to optimize and qualify the MSC-EV production for the clinical setting.
Keywords: Hematopoietic stem cells, hematopoiesis, mesenchymal stem cells, extracellular vesicles, exosomes
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Selected Publications
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Imaging flow cytometry challenges the usefulness of classically used extracellular vesicle labeling dyes and qualifies the novel dye Exoria for the labeling of mesenchymal stromal cell–extracellular vesicle preparationsIn: Cytotherapy Vol. 24 (2022) Nr. 6, pp. 619 - 628
ISSN: 1477-2566; 1465-3249Online Full Text: dx.doi.org/ (Open Access) -
Postischemic Neuroprotection Associated With Anti-Inflammatory Effects by Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Aged MiceIn: Stroke Vol. 53 (2022) Nr. 1, pp. E14 - E18
ISSN: 1524-4628; 0039-2499Online Full Text: dx.doi.org/ (Open Access) -
Circulating MicroRNAs : Posttranscriptional Regulators and Disease Markers Holding Promise in Stroke PredictionIn: Stroke Vol. 52 (2021) Nr. 3, pp. 954 - 956
ISSN: 1524-4628; 0039-2499Online Full Text: dx.doi.org/ (Open Access) -
Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesiclesIn: Cytotherapy Vol. 23 (2021) Nr. 5, pp. 373 - 380
ISSN: 1477-2566; 1465-3249Online Full Text: dx.doi.org/ (Open Access) -
Impact of mesenchymal stromal/stem cell isolation strategies on the immunomodulatory activity of their extracellular vesiclesIn: Cytotherapy Vol. 23 (2021) Nr. Suppl. 5, pp. 113
ISSN: 1477-2566; 1465-3249 -
New Light on the Horizon : Extracellular Vesicles as Diagnostic Tool in Transient Ischemic Attack and Ischemic StrokeIn: Stroke Vol. 52 (2021) Nr. 10, pp. 3348 - 3350
ISSN: 0039-2499; 1524-4628Online Full Text: dx.doi.org/ -
International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells : considerations for potential therapeutic agents to suppress coronavirus disease-19In: Cytotherapy Vol. 22 (2020) Nr. 9, pp. 482 - 485
ISSN: 1477-2566; 1465-3249Online Full Text: dx.doi.org/ (Open Access) -
Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically NeutrophilsIn: Stroke Vol. 9 (2020) Nr. 10, pp. 1825 - 1834
ISSN: 1524-4628; 0039-2499Online Full Text: dx.doi.org/ (Open Access) -
Ultrasmall gold nanoparticles (2 nm) can penetrate and enter cell nuclei in an in vitro 3D brain spheroid modelIn: Acta Biomaterialia Vol. 111 (2020) pp. 349 - 362
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
A mixed lymphocyte reaction as a functional assay for extracellular vesicles of different originsIn: Cytotherapy Vol. 21 (2019) Nr. 5, pp. 57
ISSN: 1477-2566; 1465-3249Online Full Text: dx.doi.org/ -
Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy.In: Journal of Clinical Medicine Vol. 8 (2019) Nr. 2, pp. 137
ISSN: 2077-0383Online Full Text: dx.doi.org/ (Open Access) -
Free flow electrophoresis allows preparation of extracellular vesicles with high purityIn: Cytotherapy Vol. 21 (2019) Nr. Suppl. 5, pp. 57 - S58
ISSN: 1477-2566; 1465-3249Online Full Text: dx.doi.org/ -
MSC-EVS protect mice from graft-versus-host disease pathology in a preparation dependent mannerIn: Cytotherapy Vol. 21 (2019) Nr. Suppl. 5, pp. 57
ISSN: 1477-2566; 1465-3249Online Full Text: dx.doi.org/ -
Tangential flow filtration, a potential method for the scaled preparation of extracellular vesiclesIn: Cytotherapy Vol. 21 (2019) Nr. Suppl. 5, pp. 57
ISSN: 1477-2566; 1465-3249Online Full Text: dx.doi.org/ -
Gfi1b : A key player in the genesis and maintenance of acute myeloid leukemia and myelodysplastic syndromeIn: Haematologica Vol. 103 (2018) Nr. 4, pp. 614 - 625
ISSN: 1592-8721; 0390-6078Online Full Text: dx.doi.org/ (Open Access) -
EV-TRACK : Transparent reporting and centralizing knowledge in extracellular vesicle researchIn: Nature Methods Vol. 14 (2017) Nr. 3, pp. 228 - 232
ISSN: 1548-7091; 1548-7105Online Full Text: dx.doi.org/ -
Breast cancer-derived extracellular vesicles : clinical and prognostic impactIn: Cancer Research Vol. 76 (2016) Nr. 14 Suppl., pp. 3152
ISSN: 0008-5472; 1538-7445Online Full Text: dx.doi.org/ -
Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in NanomedicineIn: ACS Nano Vol. 10 (2016) Nr. 4, pp. 3886 - 3899
ISSN: 1936-086X; 1936-0851Online Full Text: dx.doi.org/ -
GFI1 as a novel prognostic and therapeutic factor for AML/MDSIn: Leukemia Vol. 30 (2016) Nr. 6, pp. 1237 - 1245
ISSN: 0887-6924; 1476-5551Online Full Text: dx.doi.org/ -
CD133 allows elaborated discrimination and quantification of haematopoietic progenitor subsets in human haematopoietic stem cell transplantsIn: British Journal of Haematology Vol. 169 (2015) Nr. 6, pp. 868 - 878
ISSN: 0007-1048; 1365-2141Online Full Text: dx.doi.org/ -
Multipotent Hematopoietic Progenitors Divide Asymmetrically to Create Progenitors of the Lymphomyeloid and Erythromyeloid Lineages (vol 3, 1058, 2014)In: Stem Cell Reports Vol. 5 (2015) Nr. 1, pp. 154 - 155
ISSN: 2213-6711Online Full Text: dx.doi.org/ (Open Access) -
Autologous bone marrow mononuclear cell therapy improves symptoms in patients with end-stage peripheral arterial disease and reduces inflammation-associated parametersIn: Cytotherapy Vol. 16 (2014) Nr. 9, pp. 1270 - 1279
ISSN: 1477-2566; 1465-3249Online Full Text: dx.doi.org/ -
Evaluation of human platelet lysate versus fetal bovine serum for culture of mesenchymal stromal cellsIn: Cytotherapy Vol. 16 (2014) Nr. 2, pp. 170 - 180
ISSN: 1477-2566; 1465-3249Online Full Text: dx.doi.org/ -
MSC-derived exosomes : a novel tool to treat therapy-refractory graft-versus-host diseaseIn: Leukemia Vol. 28 (2014) Nr. 4, pp. 970 - 973
ISSN: 0887-6924; 1476-5551Online Full Text: dx.doi.org/ -
Multipotent hematopoietic progenitors divide asymmetrically to create progenitors of the lymphomyeloid and erythromyeloid lineagesIn: Stem Cell Reports Vol. 3 (2014) Nr. 6, pp. 1058 - 1072
ISSN: 2213-6711Online Full Text: dx.doi.org/ (Open Access) -
Revision of the Human Hematopoietic Tree: Granulocyte Subtypes Derive from Distinct Hematopoietic LineagesIn: Cell Reports Vol. 3 (2013) Nr. 5, pp. 1539 - 1552
ISSN: 2211-1247Online Full Text: dx.doi.org/ -
Vemurafenib reverses immunosuppression by myeloid derived suppressor cellsIn: Cancer Research Vol. 73 (2013) Nr. 8 Suppl., pp. 4714
ISSN: 0008-5472Online Full Text: dx.doi.org/ -
Preclinical Testing of a Novel Axl-Kinase Inhibitor in Chronic Lymphocytic LeukemiaIn: Blood Vol. 120 (2012) Nr. 21,
ISSN: 0006-4971; 1528-0020