ZMB Member Bernd Giebel

ZMB Member
Bernd Giebel

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Bernd Giebel portrait
© B. Giebel

Prof. Dr. Bernd Giebel

Group Giebel

Institute for Transfusion Medicine
University Hospital Essen
Hufelandstraße 55
45122 Essen

Research Overview

The group of Bernd Giebel investigates lineage relationships of early human hematopoietic progenitors as well as mechanisms controlling their self-renewal and lineage specification. In this context the group is especially interested in dissecting roles of asymmetric cell division, which they have proven to occur in at least a proportion of the cells. Since 2009, as a second topic the group is also working in the fast expanding field of extracellular vesicles (EVs), often termed exosomes or microvesicles, respectively. Here, the group is especially interested in deciphering the therapeutic potential of EVs released from mesenchymal stem/stromal cells (MSCs). After demonstrating therapeutic potentials in different systems including the treatment of a graft-versus-host disease patient, the group now aims to optimize and qualify the MSC-EV production for the clinical setting.
Keywords: Hematopoietic stem cells, hematopoiesis, mesenchymal stem cells, extracellular vesicles, exosomes
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Selected Publications

    Journal articles

  • Tertel, Tobias; Schoppet, Melanie; Stambouli, Oumaima; Al-Jipouri, Ali; James, Patrick F.; Giebel, Bernd
    Imaging flow cytometry challenges the usefulness of classically used extracellular vesicle labeling dyes and qualifies the novel dye Exoria for the labeling of mesenchymal stromal cell–extracellular vesicle preparations
    In: Cytotherapy Vol. 24 (2022) Nr. 6, pp. 619 - 628
    ISSN: 1477-2566; 1465-3249
    Online Full Text: dx.doi.org/ (Open Access)
  • Wang, Chen; Börger, Verena; Mohamud Yusuf, Ayan; Tertel, Tobias; Stambouli, Oumaima; Murke, Florian; Freund, Nico; Kleinschnitz, Christoph; Herz, Josephine; Gunzer, Matthias; Popa-Wagner, Aurel; Döppner, Thorsten R.; Giebel, Bernd; Hermann, Dirk M.
    Postischemic Neuroprotection Associated With Anti-Inflammatory Effects by Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Aged Mice
    In: Stroke Vol. 53 (2022) Nr. 1, pp. E14 - E18
    ISSN: 1524-4628; 0039-2499
    Online Full Text: dx.doi.org/ (Open Access)
  • Hermann, Dirk M.; Döppner, Thorsten R.; Giebel, Bernd
    Circulating MicroRNAs : Posttranscriptional Regulators and Disease Markers Holding Promise in Stroke Prediction
    In: Stroke Vol. 52 (2021) Nr. 3, pp. 954 - 956
    ISSN: 1524-4628; 0039-2499
    Online Full Text: dx.doi.org/ (Open Access)
  • Gimona, Mario; Brizzi, Maria Felice; Choo, Andre Boon Hwa; Dominici, Massimo; Davidson, Sean M.; Grillari, Johannes; Hermann, Dirk M.; Hill, Andrew F.; de Kleijn, Dominique; Lai, Ruenn Chai; Lai, Charles P.; Lim, Rebecca; Monguió-Tortajada, Marta; Muraca, Maurizio; Ochiya, Takahiro; Ortiz, Luis A.; Toh, Wei Seong; Yi, Yong Weon; Witwer, Kenneth W.; Giebel, Bernd; Lim, Sai Kiang
    Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles
    In: Cytotherapy Vol. 23 (2021) Nr. 5, pp. 373 - 380
    ISSN: 1477-2566; 1465-3249
    Online Full Text: dx.doi.org/ (Open Access)
  • Stambouli, O.; Dittrich, Robin; Nardi-Bauer, Fabiola; Tertel, Tobias; Horn, Peter; Giebel, Bernd
    Impact of mesenchymal stromal/stem cell isolation strategies on the immunomodulatory activity of their extracellular vesicles
    In: Cytotherapy Vol. 23 (2021) Nr. Suppl. 5, pp. 113
    ISSN: 1477-2566; 1465-3249
  • Hermann, Dirk M.; Döppner, Thorsten R.; Giebel, Bernd
    New Light on the Horizon : Extracellular Vesicles as Diagnostic Tool in Transient Ischemic Attack and Ischemic Stroke
    In: Stroke Vol. 52 (2021) Nr. 10, pp. 3348 - 3350
    ISSN: 0039-2499; 1524-4628
    Online Full Text: dx.doi.org/
  • Börger, Verena; Weiss, Daniel J.; Anderson, Johnathon D.; Borràs, Francesc E.; Bussolati, Benedetta; Carter, David R.F.; Dominici, Massimo; Falcón-Pérez, Juan M.; Gimona, Mario; Hill, Andrew F.; Hoffman, Andrew M.; de Kleijn, Dominique; Levine, Bruce L.; Lim, Rebecca; Lötvall, Jan; Mitsialis, S. Alex; Monguió-Tortajada, Marta; Muraca, Maurizio; Nieuwland, Rienk; Nowocin, Anna; O'Driscoll, Lorraine; Ortiz, Luis A.; Phinney, Donald G; Reischl, Ilona; Rohde, Eva; Sanzenbacher, Ralf; Théry, Clotilde; Toh, Wei Seong; Witwer, Kenneth W.; Lim, Sai Kiang; Giebel, Bernd
    International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells : considerations for potential therapeutic agents to suppress coronavirus disease-19
    In: Cytotherapy Vol. 22 (2020) Nr. 9, pp. 482 - 485
    ISSN: 1477-2566; 1465-3249
    Online Full Text: dx.doi.org/ (Open Access)
  • Wang, Chen; Börger, Verena; Sardari, Maryam; Murke, Florian; Skuljec, Jelena; Pul, Refik; Hagemann, Nina; Dzyubenko, Egor; Dittrich, Robin; Gregorius, Jonas; Hasenberg, Mike; Kleinschnitz, Christoph; Popa-Wagner, Aurel; Döppner, Thorsten R.; Gunzer, Matthias; Giebel, Bernd; Hermann, Dirk M.
    Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils
    In: Stroke Vol. 9 (2020) Nr. 10, pp. 1825 - 1834
    ISSN: 1524-4628; 0039-2499
    Online Full Text: dx.doi.org/ (Open Access)
  • Sokolova, Viktoriya; Nzou, Goodwell; van der Meer, Selina; Ruks, Tatjana; Heggen, Marc; Loza, Kateryna; Hagemann, Nina; Murke, Florian; Giebel, Bernd; Hermann, Dirk M.; Atala, Anthony J.; Epple, Matthias
    Ultrasmall gold nanoparticles (2 nm) can penetrate and enter cell nuclei in an in vitro 3D brain spheroid model
    In: Acta Biomaterialia Vol. 111 (2020) pp. 349 - 362
    ISSN: 1878-7568; 1742-7061
    Online Full Text: dx.doi.org/
  • Bremer, M.; Börger, Verena; Horn, Peter; Giebel, Bernd
    A mixed lymphocyte reaction as a functional assay for extracellular vesicles of different origins
    In: Cytotherapy Vol. 21 (2019) Nr. 5, pp. 57
    ISSN: 1477-2566; 1465-3249
    Online Full Text: dx.doi.org/
  • Gussenhoven, Ruth; Klein, Luise; Ophelders, Daan R M G; Habets, Denise H J; Giebel, Bernd; Kramer, Boris W; Schurgers, Leon J; Reutelingsperger, Chris P M; Wolfs, Tim G A M
    Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy.
    In: Journal of Clinical Medicine Vol. 8 (2019) Nr. 2, pp. 137
    ISSN: 2077-0383
    Online Full Text: dx.doi.org/ (Open Access)
  • Staubach, S.; Reiter, C.; Weber, G.; Giebel, Bernd
    Free flow electrophoresis allows preparation of extracellular vesicles with high purity
    In: Cytotherapy Vol. 21 (2019) Nr. Suppl. 5, pp. 57 - S58
    ISSN: 1477-2566; 1465-3249
    Online Full Text: dx.doi.org/
  • Madel, R.; Borger, V.; Bremer, M.; Horn, Peter; Baba, Hideo Andreas; Brandau, Sven; Buer, Jan; Giebel, Bernd; Kirschning, Carsten Jürgen
    MSC-EVS protect mice from graft-versus-host disease pathology in a preparation dependent manner
    In: Cytotherapy Vol. 21 (2019) Nr. Suppl. 5, pp. 57
    ISSN: 1477-2566; 1465-3249
    Online Full Text: dx.doi.org/
  • Börger, Verena; Dittrich, R.; Staubach, S.; Zumegen, S.; Horn, Peter; Giebel, Bernd
    Tangential flow filtration, a potential method for the scaled preparation of extracellular vesicles
    In: Cytotherapy Vol. 21 (2019) Nr. Suppl. 5, pp. 57
    ISSN: 1477-2566; 1465-3249
    Online Full Text: dx.doi.org/
  • Thivakaran, Aniththa; Botezatu, Lacramioara; Hönes, Judith M.; Schütte, Judith; Vassen, Lothar; Al-Matary, Yahya S.; Patnana, Pradeep; Zeller, Amos; Heuser, Michael; Thol, Felicitas; Gabdoulline, Razif; Olberding, Nadine; Frank, Daria; Suslo, Marina; Köster, Renata; Lennartz, Klaus; Görgens, Andre; Giebel, Bernd; Opalka, Bertram; Dührsen, Ulrich; Khandanpour, Cyrus
    Gfi1b : A key player in the genesis and maintenance of acute myeloid leukemia and myelodysplastic syndrome
    In: Haematologica Vol. 103 (2018) Nr. 4, pp. 614 - 625
    ISSN: 1592-8721; 0390-6078
    Online Full Text: dx.doi.org/ (Open Access)
  • Van Deun, Jan; Mestdagh, Pieter; Agostinis, Patrizia; Akay, Özden; Anand, Sushma; Anckaert, Jasper; Martinez, Zoraida Andreu; Baetens, Tine; Beghein, Els; Bertier, Laurence; Berx, Geert; Boere, Janneke; Boukouris, Stephanie; Bremer, Michel; Buschmann, Dominik; Byrd, James B.; Casert, Clara; Cheng, Lesley; Cmoch, Anna; Daveloose, Delphine; De Smedt, Eva; Demirsoy, Seyma; Depoorter, Victoria; Dhondt, Bert; Driedonks, Tom A.P.; Dudek, Aleksandra; Elsharawy, Abdou; Floris, Ilaria; Foers, Andrew D.; Gärtner, Kathrin; Garg, Abhishek D.; Geeurickx, Edward; Gettemans, Jan; Ghazavi, Farzaneh; Giebel, Bernd; Kormelink, Tom Groot; Hancock, Grace; Helsmoortel, Hetty; Hill, Andrew F.; Hyenne, Vincent; Kalra, Hina; Kim, David; Kowal, Joanna; Kraemer, Sandra; Leidinger, Petra; Leonelli, Carina; Liang, Yaxuan; Lippens, Lien; Liu, Shu; Lo Cicero, Alessandra; Martin, Shaun; Mathivanan, Suresh; Mathiyalagan, Prabhu; Matusek, Támas; Milani, Gloria; Monguió-Tortajada, Marta; Mus, Liselot M.; Muth, Dillon C.; Németh, Andrea; Nolte-'T Hoen, Esther N.M.; O'Driscoll, Lorraine; Palmulli, Roberta; Pfaffl, Michael W.; Primdal-Bengtson, Bjarke; Romano, Erminia; Rousseau, Quentin; Sahoo, Susmita; Sampaio, Natalia; Samuel, Monisha; Scicluna, Benjamin; Soen, Bieke; Steels, Anneleen; Swinnen, Johannes V.; Takatalo, Maarit; Thaminy, Safia; Théry, Clotilde; Tulkens, Joeri; Van Audenhove, Isabel; Van Der Grein, Susanne; Van Goethem, Alan; Van Herwijnen, Martijn J.; Van Niel, Guillaume; Van Roy, Nadine; Van Vliet, Alexander R.; Vandamme, Niels; Vanhauwaert, Suzanne; Vergauwen, Glenn; Verweij, Frederik; Wallaert, Annelynn; Wauben, Marca; Witwer, Kenneth W.; Zonneveld, Marijke I.; De Wever, Olivier; Vandesompele, Jo; Hendrix, An
    EV-TRACK : Transparent reporting and centralizing knowledge in extracellular vesicle research
    In: Nature Methods Vol. 14 (2017) Nr. 3, pp. 228 - 232
    ISSN: 1548-7091; 1548-7105
    Online Full Text: dx.doi.org/
  • König, Lisa; Rebmann, Vera; Hoffmann, Oliver; Bittner, A. K.; Wagner, B.; Manvailer, L. F. S.; Schramm, S.; Bankfalvi, Agnes; Giebel, Bernd; Kimmig, Rainer; Horn, Peter A.; Kasimir-Bauer, Sabine
    Breast cancer-derived extracellular vesicles : clinical and prognostic impact
    In: Cancer Research Vol. 76 (2016) Nr. 14 Suppl., pp. 3152
    ISSN: 0008-5472; 1538-7445
    Online Full Text: dx.doi.org/
  • Fais, Stefano; O'Driscoll, Lorraine; Borras, Francesc E.; Buzas, Edit; Camussi, Giovanni; Cappello, Francesco; Carvalho, Joana; Cordeiro Da Silva, Anabela; Del Portillo, Hernando; El Andaloussi, Samir; Ficko Trček, Tanja; Furlan, Roberto; Hendrix, An; Gursel, Ihsan; Kralj-Iglic, Veronika; Kaeffer, Bertrand; Kosanovic, Maja; Lekka, Marilena E.; Lipps, Georg; Logozzi, Mariantonia; Marcilla, Antonio; Sammar, Marei; Llorente, Alicia; Nazarenko, Irina; Oliveira, Carla; Pocsfalvi, Gabriella; Rajendran, Lawrence; Raposo, Graça; Rohde, Eva; Siljander, Pia; Van Niel, Guillaume; Vasconcelos, M. Helena; Yáñez-Mó, María; Yliperttula, Marjo L.; Zarovni, Natasa; Zavec, Apolonija Bedina; Giebel, Bernd
    Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine
    In: ACS Nano Vol. 10 (2016) Nr. 4, pp. 3886 - 3899
    ISSN: 1936-086X; 1936-0851
    Online Full Text: dx.doi.org/
  • Hönes, J M; Botezatu, L; Helness, A; Vadnais, C; Vassen, L; Robert, F; Hergenhan, S M; Thivakaran, A; Schütte, J; Al-Matary, Y S; Lams, R F; Fraszscak, J; Makishima, H; Radivoyevitch, T; Przychodzen, B; da Conceição Castro, S V; Görgens, A; Giebel, Bernd; Klein-Hitpaß, Ludger; Lennartz, K; Heuser, M; Thiede, C; Ehninger, G; Dührsen, Ulrich; Maciejewski, J; Möröy, T; Khandanpour, Cyrus
    GFI1 as a novel prognostic and therapeutic factor for AML/MDS
    In: Leukemia Vol. 30 (2016) Nr. 6, pp. 1237 - 1245
    ISSN: 0887-6924; 1476-5551
    Online Full Text: dx.doi.org/
  • Radtke, Stefan; Görgens, André; Kordelas, Lambros; Schmidt, Markus; Kimmig, Rainer; Köninger, Angela; Horn, Peter; Giebel, Bernd
    CD133 allows elaborated discrimination and quantification of haematopoietic progenitor subsets in human haematopoietic stem cell transplants
    In: British Journal of Haematology Vol. 169 (2015) Nr. 6, pp. 868 - 878
    ISSN: 0007-1048; 1365-2141
    Online Full Text: dx.doi.org/
  • Goergens, Andre; Ludwig, Anna-Krist; Moellmann, Michael; Krawczyk, Adalbert; Dürig, Jan; Hanenberg, Helmut; Horn, PeterA; Giebel, Bernd
    Multipotent Hematopoietic Progenitors Divide Asymmetrically to Create Progenitors of the Lymphomyeloid and Erythromyeloid Lineages (vol 3, 1058, 2014)
    In: Stem Cell Reports Vol. 5 (2015) Nr. 1, pp. 154 - 155
    ISSN: 2213-6711
    Online Full Text: dx.doi.org/ (Open Access)
  • Malyar, Mohammad; Radtke, Stefan; Malyar, Khalil; Arjumand, Jawed; Horn, Peter; Kröger, Knut; Freisinger, Eva; Reinecke, Holger; Giebel, Bernd; Brock, Franz-Eduard
    Autologous bone marrow mononuclear cell therapy improves symptoms in patients with end-stage peripheral arterial disease and reduces inflammation-associated parameters
    In: Cytotherapy Vol. 16 (2014) Nr. 9, pp. 1270 - 1279
    ISSN: 1477-2566; 1465-3249
    Online Full Text: dx.doi.org/
  • Hemeda, Hatim; Giebel, Bernd; Wagner, Wolfgang
    Evaluation of human platelet lysate versus fetal bovine serum for culture of mesenchymal stromal cells
    In: Cytotherapy Vol. 16 (2014) Nr. 2, pp. 170 - 180
    ISSN: 1477-2566; 1465-3249
    Online Full Text: dx.doi.org/
  • Kordelas, L; Rebmann, Vera; Ludwig, A-K; Radtke, Stefan; Ruesing, J; Döppner, Thorsten R.; Epple, Matthias; Horn, Peter; Beelen, Dietrich; Giebel, Bernd
    MSC-derived exosomes : a novel tool to treat therapy-refractory graft-versus-host disease
    In: Leukemia Vol. 28 (2014) Nr. 4, pp. 970 - 973
    ISSN: 0887-6924; 1476-5551
    Online Full Text: dx.doi.org/
  • Gorgens, A.; Ludwig, A. K.; Mollmann, M.; Krawczyk, Adalbert; Dürig, Jan; Hanenberg, H.; Horn, Peter; Giebel, Bernd
    Multipotent hematopoietic progenitors divide asymmetrically to create progenitors of the lymphomyeloid and erythromyeloid lineages
    In: Stem Cell Reports Vol. 3 (2014) Nr. 6, pp. 1058 - 1072
    ISSN: 2213-6711
    Online Full Text: dx.doi.org/ (Open Access)
  • Görgens, André; Radtke, Stefan; Möllmann, Michael; Cross, Michael; Dürig, Jan; Horn, Peter; Giebel, Bernd
    Revision of the Human Hematopoietic Tree: Granulocyte Subtypes Derive from Distinct Hematopoietic Lineages
    In: Cell Reports Vol. 3 (2013) Nr. 5, pp. 1539 - 1552
    ISSN: 2211-1247
    Online Full Text: dx.doi.org/
  • Weide, Benjamin; Schilling, Bastian; Paschen, Annette; Görgens, Andre; Sucker, Antje; Zhao, Fang; Giebel, Bernd; Griewank, Klaus; Schadendorf, Dirk
    Vemurafenib reverses immunosuppression by myeloid derived suppressor cells
    In: Cancer Research Vol. 73 (2013) Nr. 8 Suppl., pp. 4714
    ISSN: 0008-5472
    Online Full Text: dx.doi.org/
  • Goebel, Maria; Möllmann, Michael; Gorgens, A.; Dührsen, Ulrich; Huttmann, A.; Giebel, Bernd; Unger, A.; Choidas, A.; Dürig, Jan
    Preclinical Testing of a Novel Axl-Kinase Inhibitor in Chronic Lymphocytic Leukemia
    In: Blood Vol. 120 (2012) Nr. 21,
    ISSN: 0006-4971; 1528-0020
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