ZMB Member Ralf Küppers
ZMB Member
Ralf Küppers
Next ZMB-Member
Prof. Dr. Ralf Küppers
Group
Molecular GeneticsInstitute of Cell Biology (Tumor Research)
University Hospital Essen
Virchowstr. 173
45122 Essen
- +49 201 723 3384
- Website
- Selected Publications
- Publication Metrics
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- ZMB Research Program
Oncology
Research Overview
B lymphocytes represent the white blood cells that produce antibodies and that play an important role in immune responses against foreign antigens (e.g. bacteria). In rare instances, B lymphocytes may undergo malignant transformation and become tumour cells. Such tumours are called B cell lymphomas or leukemias. The main research topics of the group are:
- Investigation of B cell differentiation and function in the human
- The interplay of B cells with viruses (EBV, HCV, HIV)
- Pathogenesis of human B cell lymphomas, in particular Hodgkin lymphoma
Selected Publications
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UMI or not UMI, that is the question for scRNA-seq zero-inflationIn: Nature Biotechnology (2021) in press
ISSN: 1087-0156; 1546-1696; 0733-222XOnline Full Text: dx.doi.org/ -
Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samplesIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 6232
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypesIn: Blood Vol. 136 (2020) Nr. 12, pp. 1419 - 1432
ISSN: 1528-0020Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Identifying genetic lesions in ocular adnexal extranodal marginal zone lymphomas of the malt subtype by whole genome, whole exome and targeted sequencingIn: Cancers Vol. 12 (2020) Nr. 4, pp. 986
ISSN: 2072-6694Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphomaIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 2465
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Pan-cancer analysis of whole genomesIn: Nature Vol. 578 (2020) Nr. 7793, pp. 82 - 93
ISSN: 0028-0836; 1476-4687Online Full Text: dx.doi.org/ (Open Access) -
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samplesIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4748
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Sex differences in oncogenic mutational processesIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4330
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Fibroblasts in nodular sclerosing classical Hodgkin lymphoma are defined by a specific phenotype and protect tumor cells from brentuximab-Vedotin induced injuryIn: Cancers Vol. 11 (2019) Nr. 11, Article-No: 1687
ISSN: 2072-6694Online Full Text: dx.doi.org/ (Open Access) -
Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphomaIn: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1459
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt LymphomaIn: Cancer Research Vol. 79 (2019) Nr. 12, pp. 3125 - 3138
ISSN: 1538-7445; 0008-5472Online Full Text: dx.doi.org/ -
Migration properties distinguish tumor cells of classical hodgkin lymphoma from anaplastic large cell lymphoma cellsIn: Cancers Vol. 11 (2019) Nr. 10, pp. 1484
ISSN: 2072-6694Online Full Text: dx.doi.org/ (Open Access) -
An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphomaIn: Leukemia Vol. 32 (2018) Nr. 1, pp. 92 - 101
ISSN: 0887-6924; 1476-5551Online Full Text: dx.doi.org/ -
Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individualsIn: Blood Vol. 131 (2018) Nr. 5, pp. 546 - 557
ISSN: 1528-0020; 0006-4971Online Full Text: dx.doi.org/ (Open Access) -
Critical influences on the pathogenesis of follicular lymphomaIn: Blood Vol. 131 (2018) Nr. 21, pp. 2297 - 2306
ISSN: 1528-0020; 0006-4971Online Full Text: dx.doi.org/ -
Human CD30⁺ B cells represent a unique subset related to Hodgkin lymphoma cellsIn: The Journal of Clinical Investigation Vol. 128 (2018) Nr. 7, pp. 2996 - 3007
ISSN: 1558-8238; 0021-9738Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
IG-MYC⁺ neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomasIn: Blood Vol. 132 (2018) Nr. 21, pp. 2280 - 2285
ISSN: 1528-0020Online Full Text: dx.doi.org/ -
DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemiaIn: Nature Genetics Vol. 48 (2016) Nr. 3, pp. 253 - 264
ISSN: 1061-4036; 1546-1718Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphomaIn: Blood Vol. 128 (2016) Nr. 23, pp. 2666 - 2670
ISSN: 0006-4971; 1528-0020Online Full Text: dx.doi.org/ (Open Access) -
Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphomaIn: Leukemia Vol. 30 (2016) Nr. 4, pp. 844 - 853
ISSN: 0887-6924; 1476-5551Online Full Text: dx.doi.org/ -
Human memory B cellsIn: Leukemia Vol. 30 (2016) Nr. 12, pp. 2283 - 2292
ISSN: 0887-6924; 1476-5551Online Full Text: dx.doi.org/ -
The International Human Epigenome Consortium : A Blueprint for Scientific Collaboration and DiscoveryIn: Cell Vol. 167 (2016) Nr. 5, pp. 1145 - 1149
ISSN: 0092-8674Online Full Text: dx.doi.org/ (Open Access) -
DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional controlIn: Nature Genetics Vol. 47 (2015) Nr. 11, pp. 1316 - 1325
ISSN: 1061-4036; 1546-1718Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Genomic and epigenomic co-evolution in follicular lymphomasIn: Leukemia Vol. 29 (2015) Nr. 2, pp. 456 - 463
ISSN: 1476-5551Online Full Text: dx.doi.org/ -
Progressive Epigenetic Programming during B Cell Maturation Is Reflected in a Continuum of Epigenetic Disease Phenotypes in Chronic Lymphocytic LeukemiaIn: Blood Vol. 126 (2015) Nr. 23, pp. 2436
ISSN: 0006-4971; 1528-0020Online Full Text: dx.doi.org/ -
Whole-genome fingerprint of the DNA methylome during human B cell differentiationIn: Nature Genetics Vol. 47 (2015) Nr. 7, pp. 746 - 756
ISSN: 1061-4036; 1546-1718Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
A microRNA involved in the germinal center reactionIn: Blood Vol. 124 (2014) Nr. 2, pp. 158 - 159
ISSN: 1528-0020Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphomaIn: Blood Vol. 123 (2014) Nr. 8, pp. 1187 - 1198
ISSN: 1528-0020Online Full Text: dx.doi.org/ -
Characterization of the DNA Methylome during Human B-Cell DifferentiationIn: Blood Vol. 124 (2014) Nr. 21, pp. 4346
ISSN: 0006-4971; 1528-0020 -
Pathogenesis, diagnosis, and treatment of composite lymphomasIn: The Lancet Oncology Vol. 15 (2014) Nr. 10, pp. e435 - 46
ISSN: 1470-2045; 1474-5488Online Full Text: dx.doi.org/ -
The PRDX2 gene is transcriptionally silenced and de novo methylated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphomaIn: Blood Vol. 123 (2014) Nr. 23, pp. 3672 - 3674
ISSN: 1528-0020; 0006-4971Online Full Text: dx.doi.org/ -
Role of early B-cell factor 1 (EBF1) in Hodgkin lymphomaIn: Leukemia Vol. 27 (2013) Nr. 3, pp. 671 - 679
ISSN: 1476-5551; 0887-6924Online Full Text: dx.doi.org/ -
Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphomaIn: Blood Vol. 120 (2012) Nr. 23, pp. 4609 - 4620
ISSN: 0006-4971; 1528-0020Online Full Text: dx.doi.org/ -
Array-based DNA methylation analysis in classical Hodgkin lymphoma reveals new insights into the mechanisms underlying silencing of B cell-specific genesIn: Leukemia Vol. 26 (2012) Nr. 1, pp. 185 - 188
ISSN: 0887-6924; 1476-5551Online Full Text: dx.doi.org/ -
BLUEPRINT to decode the epigenetic signature written in bloodIn: Nature Biotechnology Vol. 30 (2012) Nr. 3, pp. 224 - 226
ISSN: 1087-0156; 1546-1696Online Full Text: dx.doi.org/ -
Combined SNP Microarray Based Genomic Mapping and Next Generation Transcriptome Sequencing Confirms the Presence of Somatic STAT3 Mutations and Identifies Novel Chromosomal Imbalances and Candidate Genes in T Large Granular Lymphocytic Leukemia (T-LGL)In: Blood Vol. 120 (2012) Nr. 21, pp. 3512
ISSN: 0006-4971; 1528-0020Online Full Text: dx.doi.org/ -
Dysregulation of global microRNA expression in splenic marginal zone lymphoma and influence of chronic hepatitis C virus infectionIn: Leukemia Vol. 26 (2012) Nr. 7, pp. 1654 - 1662
ISSN: 0887-6924; 1476-5551Online Full Text: dx.doi.org/ -
Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencingIn: Nature Genetics Vol. 44 (2012) Nr. 12, pp. 1316 - 1320
ISSN: 1061-4036; 1546-1718Online Full Text: dx.doi.org/ -
CCR7 & lymphotoxin in lymphoma nicheIn: Blood Vol. 118 (2011) Nr. 4, pp. 831 - 832
ISSN: 0006-4971; 1528-0020Online Full Text: dx.doi.org/ -
Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphomaIn: Leukemia Vol. 25 (2011) Nr. 12, pp. 1797 - 1807
ISSN: 0887-6924; 1476-5551Online Full Text: dx.doi.org/ -
NPAT mutations in Hodgkin lymphomaIn: Blood Vol. 118 (2011) Nr. 3, pp. 484 - 485
ISSN: 0006-4971; 1528-0020Online Full Text: dx.doi.org/ -
Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adultsIn: Blood Vol. 118 (2011) Nr. 1, pp. 139 - 147
ISSN: 0006-4971; 1528-0020Online Full Text: dx.doi.org/ -
From pathogenesis to treatment of chronic lymphocytic leukaemiaIn: Nature Reviews Cancer Vol. 10 (2010) Nr. 1, pp. 37 - 50
ISSN: 1474-175X; 1474-1768Online Full Text: dx.doi.org/ -
Genomic imbalances in Hodgkin lymphomaIn: Blood Vol. 116 (2010) Nr. 3, pp. 309 - 311
ISSN: 1528-0020; 0006-4971Online Full Text: dx.doi.org/ (Open Access) -
Mechanisms of aberrant GATA3 expression in classical Hodgkin lymphoma and its consequences for the cytokine profile of Hodgkin and Reed/Sternberg cellsIn: Blood Vol. 116 (2010) Nr. 20, pp. 4202 - 4211
ISSN: 1528-0020; 0006-4971Online Full Text: dx.doi.org/ (Open Access) -
Mutations of CARD11 but not TNFAIP3 may activate the NF-κB pathway in primary CNS lymphomaIn: Acta Neuropathologica Vol. 120 (2010) Nr. 4, pp. 529 - 535
ISSN: 1432-0533; 0001-6322Online Full Text: dx.doi.org/ -
The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemiaIn: Leukemia Vol. 24 (2010) Nr. 6, pp. 1152 - 1159
ISSN: 0887-6924; 1476-5551Online Full Text: dx.doi.org/