ZMB Member Ralf Küppers

ZMB Member
Ralf Küppers

Next ZMB-Member
Ralf Küppers portrait
© UKE/Küppers

Prof. Dr. Ralf Küppers

Group

Molecular Genetics

Institute of Cell Biology (Tumor Research)
University Hospital Essen
Virchowstr. 173
45122 Essen

Research Overview

B lymphocytes represent the white blood cells that produce antibodies and that play an important role in immune responses against foreign antigens (e.g. bacteria). In rare instances, B lymphocytes may undergo malignant transformation and become tumour cells. Such tumours are called B cell lymphomas or leukemias. The main research topics of the group are:

  • Investigation of B cell differentiation and function in the human
  • The interplay of B cells with viruses (EBV, HCV, HIV)
  • Pathogenesis of human B cell lymphomas, in particular Hodgkin lymphoma

Read more

Selected Publications

    Journal articles

  • Cao, Yingying; Kitanovski, Simo; Küppers, Ralf; Hoffmann, Daniel
    UMI or not UMI, that is the question for scRNA-seq zero-inflation
    In: Nature Biotechnology (2021) in press
    ISSN: 1087-0156; 1546-1696; 0733-222X
    Online Full Text: dx.doi.org/
  • Küppers, Ralf; Schadendorf, Dirk
    Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 6232
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Nadeu, Ferran; Martin-Garcia, David; Clot, Guillem; Díaz-Navarro, Ander; Duran-Ferrer, Martí; Navarro, Alba; Vilarrasa-Blasi, Roser; Kulis, Marta; Royo, Romina; Gutiérrez-Abril, Jesús; Valdés-Mas, Rafael; López, Cristina; Chapaprieta, Vicente; Puiggros, Montserrat; Castellano, Giancarlo; Costa, Dolors; Aymerich, Marta; Jares, Pedro; Espinet, Blanca; Muntañola, Ana; Ribera-Cortada, Inmaculada; Siebert, Reiner; Colomer, Dolors; Torrents, David; Gine, Eva; López-Guillermo, Armando; Küppers, Ralf; Martin-Subero, Jose I.; Puente, Xose S.; Beà, Sílvia; Campo, Elias
    Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes
    In: Blood Vol. 136 (2020) Nr. 12, pp. 1419 - 1432
    ISSN: 1528-0020
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Johansson, Patricia; Klein-Hitpaß, Ludger; Budeus, Bettina; Kuhn, Matthias; Lauber, Chris; Seifert, Michael; Roeder, Ingo; Pförtner, Roman; Stuschke, Martin; Dührsen, Ulrich; Eckstein, Anja; Dürig, Jan; Küppers, Ralf
    Identifying genetic lesions in ocular adnexal extranodal marginal zone lymphomas of the malt subtype by whole genome, whole exome and targeted sequencing
    In: Cancers Vol. 12 (2020) Nr. 4, pp. 986
    ISSN: 2072-6694
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Thurner, Lorenz; Hartmann, Sylvia; Fadle, Natalie; Regitz, Evi; Kemele, Maria; Kim, Yoo-Jin; Bohle, Rainer Maria; Nimmesgern, Anna; von Müller, Lutz; Kempf, Volkhard A. J.; Weniger, Marc; Neumann, Frank; Schneider, Nadine; Vornanen, Martine; Sundström, Christer; de Leval, Laurence; Engert, Andreas; Eichenauer, Dennis A.; Küppers, Ralf; Preuss, Klaus-Dieter; Hansmann, Martin-Leo; Pfreundschuh, Michael
    Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 2465
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium; et al.
    Pan-cancer analysis of whole genomes
    In: Nature Vol. 578 (2020) Nr. 7793, pp. 82 - 93
    ISSN: 0028-0836; 1476-4687
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk
    Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4748
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; PCAWG Tumour Subtypes and Clinical Translation; PCAWG Consortium
    Sex differences in oncogenic mutational processes
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4330
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Bankov, Katrin; Döring, Claudia; Ustaszewski, Adam; Giefing, Maciej; Herling, Marco; Cencioni, Chiara; Spallotta, Francesco; Gaetano, Carlo; Küppers, Ralf; Hansmann, Martin-Leo; Hartmann, Sylvia
    Fibroblasts in nodular sclerosing classical Hodgkin lymphoma are defined by a specific phenotype and protect tumor cells from brentuximab-Vedotin induced injury
    In: Cancers Vol. 11 (2019) Nr. 11, Article-No: 1687
    ISSN: 2072-6694
    Online Full Text: dx.doi.org/ (Open Access)
  • López, Cristina; Kleinheinz, Kortine; Aukema, Sietse M.; Rohde, Marius; Bernhart, Stephan H.; Hübschmann, Daniel; Wagener, Rabea; Toprak, Umut H.; Raimondi, Francesco; Kreuz, Markus; Waszak, Sebastian M.; Huang, Zhiqin; Sieverling, Lina; Paramasivam, Nagarajan; Seufert, Julian; Sungalee, Stephanie; Russell, Robert B.; Bausinger, Julia; Kretzmer, Helene; Ammerpohl, Ole; Bergmann, Anke K.; Binder, Hans; Borkhardt, Arndt; Brors, Benedikt; Claviez, Alexander; Doose, Gero; Feuerbach, Lars; Haake, Andrea; Hansmann, Martin-Leo; Hoell, Jessica; Hummel, Michael; Korbel, Jan O.; Lawerenz, Chris; Lenze, Dido; Radlwimmer, Bernhard; Richter, Julia; Rosenstiel, Philip; Rosenwald, Andreas; Schilhabel, Markus B.; Stein, Harald; Stilgenbauer, Stephan; Stadler, Peter F.; Szczepanowski, Monika; Weniger, Marc; Zapatka, Marc; Eils, Roland; Lichter, Peter; Loeffler, Markus; Möller, Peter; Trümper, Lorenz; Klapper, Wolfram; Wagner, Susanne; Richter, Gesine; Eils, Jürgen; Kerssemakers, Jules; Jaeger-Schmidt, Christina; Scholz, Ingrid; Borst, Christoph; Braulke, Friederike; Dreyling, Martin; Eberth, Sonja; Einsele, Hermann; Frickhofen, Norbert; Haas, Siegfried; Karsch, Dennis; Klepl, Nicole; Kneba, Michael; Lisfeld, Jasmin; Mantovani-Löffler, Luisa; Ott, German; Stadler, Christina; Staib, Peter; Zenz, Thorsten; Kube, Dieter; Kostezka, Ulrike; Binder, Vera; Leich, Ellen; Nagel, Inga; Pischimariov, Jordan; Schreiber, Stefan; Vater, Inga; Hopp, Lydia; Langenberger, David; Rosolowski, Maciej; Hoffmann, Steve; Küppers, Ralf; Burkhardt, Birgit; Schlesner, Matthias; Siebert, Reiner
    Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1459
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Hüllein, Jennifer; Słabicki, Mikołaj; Rosolowski, Maciej; Jethwa, Alexander; Habringer, Stefan; Tomska, Katarzyna; Kurilov, Roma; Lu, Junyan; Scheinost, Sebastian; Wagener, Rabea; Huang, Zhiqin; Lukas, Marina; Yavorska, Olena; Helfrich, Hanne; Scholtysik, René; Bonneau, Kyle; Tedesco, Donato; Küppers, Ralf; Klapper, Wolfram; Pott, Christiane; Stilgenbauer, Stephan; Burkhardt, Birgit; Löffler, Markus; Trümper, Lorenz H.; Hummel, Michael; Brors, Benedikt; Zapatka, Marc; Siebert, Reiner; Kreuz, Markus; Keller, Ulrich; Huber, Wolfgang; Zenz, Thorsten
    MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma
    In: Cancer Research Vol. 79 (2019) Nr. 12, pp. 3125 - 3138
    ISSN: 1538-7445; 0008-5472
    Online Full Text: dx.doi.org/
  • Goncharova, Olga; Flinner, Nadine; Bein, Julia; Döring, Claudia; Donnadieu, Emmanuel; Rikirsch, Sandy; Herling, Marco; Küppers, Ralf; Hansmann, Martin-Leo; Hartmann, Sylvia
    Migration properties distinguish tumor cells of classical hodgkin lymphoma from anaplastic large cell lymphoma cells
    In: Cancers Vol. 11 (2019) Nr. 10, pp. 1484
    ISSN: 2072-6694
    Online Full Text: dx.doi.org/ (Open Access)
  • Lollies, Anna; Hartmann, Sylvia; Schneider, Markus; Bracht, Thilo; Weiß, A.L.; Arnolds, Judith; Klein-Hitpaß, Ludger; Sitek, Barbara; Hansmann, Martin Leo; Küppers, Ralf; Weniger, Marc
    An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma
    In: Leukemia Vol. 32 (2018) Nr. 1, pp. 92 - 101
    ISSN: 0887-6924; 1476-5551
    Online Full Text: dx.doi.org/
  • Tucci, Felicia A.; Kitanovski, Simo; Johansson, Patricia; Klein-Hitpaß, Ludger; Kahraman, Alisan; Dürig, Jan; Hoffmann, Daniel; Küppers, Ralf
    Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individuals
    In: Blood Vol. 131 (2018) Nr. 5, pp. 546 - 557
    ISSN: 1528-0020; 0006-4971
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Stevenson, Freda K.
    Critical influences on the pathogenesis of follicular lymphoma
    In: Blood Vol. 131 (2018) Nr. 21, pp. 2297 - 2306
    ISSN: 1528-0020; 0006-4971
    Online Full Text: dx.doi.org/
  • Weniger, Marc; Tiacci, Enrico; Schneider, Stefanie; Arnolds, Judith; Rüschenbaum, Sabrina; Duppach, Janine; Seifert, Marc; Döring, Claudia; Hansmann, Martin-Leo; Küppers, Ralf
    Human CD30⁺ B cells represent a unique subset related to Hodgkin lymphoma cells
    In: The Journal of Clinical Investigation Vol. 128 (2018) Nr. 7, pp. 2996 - 3007
    ISSN: 1558-8238; 0021-9738
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Wagener, Rabea; López, Cristina; Kleinheinz, Kortine; Bausinger, Julia; Aukema, Sietse M.; Nagel, Inga; Toprak, Umut H.; Seufert, Julian; Altmüller, Janine; Thiele, Holger; Schneider, Christof; Kolarova, Julia; Park, Jeongbin; Hübschmann, Daniel; Murga Penas, Eva M.; Drexler, Hans G.; Attarbaschi, Andishe; Hovland, Randi; Kjeldsen, Eigil; Kneba, Michael; Kontny, Udo; de Leval, Laurence; Nürnberg, Peter; Oschlies, Ilske; Oscier, David; Schlegelberger, Brigitte; Stilgenbauer, Stephan; Wössmann, Wilhelm; Schlesner, Matthias; Burkhardt, Birgit; Klapper, Wolfram; Jaffe, Elaine S.; Küppers, Ralf; Siebert, Reiner
    IG-MYC⁺ neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas
    In: Blood Vol. 132 (2018) Nr. 21, pp. 2280 - 2285
    ISSN: 1528-0020
    Online Full Text: dx.doi.org/
  • Oakes, Christopher C; Seifert, Marc; Assenov, Yassen; Gu, Lei; Przekopowitz, Martina; Ruppert, Amy S; Wang, Qi; Imbusch, Charles D; Serva, Andrius; Koser, Sandra D; Brocks, David; Lipka, Daniel B; Bogatyrova, Olga; Weichenhan, Dieter; Brors, Benedikt; Rassenti, Laura; Kipps, Thomas J; Mertens, Daniel; Zapatka, Marc; Lichter, Peter; Döhner, Hartmut; Küppers, Ralf; Zenz, Thorsten; Stilgenbauer, Stephan; Byrd, John C; Plass, Christoph
    DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia
    In: Nature Genetics Vol. 48 (2016) Nr. 3, pp. 253 - 264
    ISSN: 1061-4036; 1546-1718
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Mansouri, Larry; Noerenberg, Daniel; Young, Emma; Mylonas, Elena; Abdulla, Maysaa; Frick, Mareike; Asmar, Fazila; Ljungström, Viktor; Schneider, Markus; Yoshida, Kenichi; Skaftason, Aron; Pandzic, Tatjana; Gonzalez, Blanca; Tasidou, Anna; Waldhueter, Nils; Rivas-Delgado, Alfredo; Angelopoulou, Maria; Ziepert, Marita; Arends, Christopher Maximilian; Couronné, Lucile; Lenze, Dido; Baldus, Claudia D; Bastard, Christian; Okosun, Jessica; Fitzgibbon, Jude; Dörken, Bernd; Drexler, Hans G; Roos-Weil, Damien; Schmitt, Clemens A; Munch-Petersen, Helga D; Zenz, Thorsten; Hansmann, Martin-Leo; Strefford, Jonathan C; Enblad, Gunilla; Bernard, Olivier A; Ralfkiaer, Elisabeth; Erlanson, Martin; Korkolopoulou, Penelope; Hultdin, Magnus; Papadaki, Theodora; Grønbæk, Kirsten; Lopez-Guillermo, Armando; Ogawa, Seishi; Küppers, Ralf; Stamatopoulos, Kostas; Stavroyianni, Niki; Kanellis, George; Rosenwald, Andreas; Campo, Elias; Amini, Rose-Marie; Ott, German; Vassilakopoulos, Theodoros P; Hummel, Michael; Rosenquist, Richard; Damm, Frederik
    Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma
    In: Blood Vol. 128 (2016) Nr. 23, pp. 2666 - 2670
    ISSN: 0006-4971; 1528-0020
    Online Full Text: dx.doi.org/ (Open Access)
  • Hartmann, S; Schuhmacher, B; Rausch, T; Fuller, L; Döring, C; Weniger, Marc; Lollies, A; Weiser, C; Thurner, L; Rengstl, B; Brunnberg, U; Vornanen, M; Pfreundschuh, M; Benes, V; Küppers, Ralf; Newrzela, S; Hansmann, M-L
    Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphoma
    In: Leukemia Vol. 30 (2016) Nr. 4, pp. 844 - 853
    ISSN: 0887-6924; 1476-5551
    Online Full Text: dx.doi.org/
  • Seifert, M; Küppers, Ralf
    Human memory B cells
    In: Leukemia Vol. 30 (2016) Nr. 12, pp. 2283 - 2292
    ISSN: 0887-6924; 1476-5551
    Online Full Text: dx.doi.org/
  • Stunnenberg, Hendrik G; Hirst, Martin; Abrignani, Sergio; Adams, David; de Almeida, Melanie; Altucci, Lucia; Amin, Viren; Amit, Ido; Antonarakis, Stylianos E; Aparicio, Samuel; Arima, Takahiro; Arrigoni, Laura; Arts, Rob; Asnafi, Vahid; Esteller, Manel; Bae, Jae-Bum; Bassler, Kevin; Beck, Stephan; Berkman, Benjamin; Bernstein, Bradley E; Bilenky, Mikhail; Bird, Adrian; Bock, Christoph; Boehm, Bernhard; Bourque, Guillaume; Breeze, Charles E; Brors, Benedikt; Bujold, David; Burren, Oliver; Bussemakers, Marion J; Butterworth, Adam; Campo, Elias; Carrillo-de-Santa-Pau, Enrique; Chadwick, Lisa; Chan, Kui Ming; Chen, Wei; Cheung, Tom H; Chiapperino, Luca; Choi, Nak Hyen; Chung, Ho-Ryun; Clarke, Laura; Connors, Joseph M; Cronet, Philippe; Danesh, John; Dermitzakis, Manolis; Drewes, Gerard; Durek, Pawel; Dyke, Stephanie; Dylag, Tomasz; Eaves, Connie J; Ebert, Peter; Eils, Roland; Eils, Jürgen; Ennis, Catherine A; Enver, Tariq; Feingold, Elise A; Felder, Bärbel; Ferguson-Smith, Anne; Fitzgibbon, Jude; Flicek, Paul; Foo, Roger S-Y; Fraser, Peter; Frontini, Mattia; Furlong, Eileen; Gakkhar, Sitanshu; Gasparoni, Nina; Gasparoni, Gilles; Geschwind, Daniel H; Gla?ar, Petar; Graf, Thomas; Grosveld, Frank; Guan, Xin-Yuan; Guigo, Roderic; Gut, Ivo G; Hamann, Alf; Han, Bok-Ghee; Harris, R Alan; Heath, Simon; Helin, Kristian; Hengstler, Jan G; Heravi-Moussavi, Alireza; Herrup, Karl; Hill, Steven; Hilton, Jason A; Hitz, Benjamin C; Horsthemke, Bernhard; Hu, Ming; Hwang, Joo-Yeon; Ip, Nancy Y; Ito, Takashi; Javierre, Biola-Maria; Jenko, Sasa; Jenuwein, Thomas; Joly, Yann; Jones, Steven J M; Kanai, Yae; Kang, Hee Gyung; Karsan, Aly; Kiemer, Alexandra K; Kim, Song Cheol; Kim, Bong-Jo; Kim, Hyeon-Hoe; Kimura, Hiroshi; Kinkley, Sarah; Klironomos, Filippos; Koh, In-Uk; Kostadima, Myrto; Kressler, Christopher; Kreuzhuber, Roman; Kundaje, Anshul; Küppers, Ralf; Larabell, Carolyn; Lasko, Paul; Lathrop, Mark; Lee, Daniel H S; Lee, Suman; Lehrach, Hans; Leitão, Elsa; Lengauer, Thomas; Lernmark, Åke; Leslie, R David; Leung, Gilberto K K; Leung, Danny; Loeffler, Markus; Ma, Yussanne; Mai, Antonello; Manke, Thomas; Marcotte, Eric R; Marra, Marco A; Martens, Joost H A; Martin-Subero, Jose Ignacio; Maschke, Karen; Merten, Christoph; Milosavljevic, Aleksandar; Minucci, Saverio; Mitsuyama, Totai; Moore, Richard A; Müller, Fabian; Mungall, Andrew J; Netea, Mihai G; Nordström, Karl; Norstedt, Irene; Okae, Hiroaki; Onuchic, Vitor; Ouellette, Francis; Ouwehand, Willem; Pagani, Massimiliano; Pancaldi, Vera; Pap, Thomas; Pastinen, Tomi; Patel, Ronak; Paul, Dirk S; Pazin, Michael J; Pelicci, Pier Giuseppe; Phillips, Anthony G; Polansky, Julia; Porse, Bo; Pospisilik, J Andrew; Prabhakar, Shyam; Procaccini, Dena C; Radbruch, Andreas; Rajewsky, Nikolaus; Rakyan, Vardham; Reik, Wolf; Ren, Bing; Richardson, David; Richter, Andreas; Rico, Daniel; Roberts, David J; Rosenstiel, Philip; Rothstein, Mark; Salhab, Abdulrahman; Sasaki, Hiroyuki; Satterlee, John S; Sauer, Sascha; Schacht, Claudia; Schmidt, Florian; Schmitz, Gerd; Schreiber, Stefan; Schröder, Christopher; Schübeler, Dirk; Schultze, Joachim L; Schulyer, Ronald P; Schulz, Marcel; Seifert, Martin; Shirahige, Katsuhiko; Siebert, Reiner; Sierocinski, Thomas; Siminoff, Laura; Sinha, Anupam; Soranzo, Nicole; Spicuglia, Salvatore; Spivakov, Mikhail; Steidl, Christian; Strattan, J Seth; Stratton, Michael; Südbeck, Peter; Sun, Hao; Suzuki, Narumi; Suzuki, Yutaka; Tanay, Amos; Torrents, David; Tyson, Frederick L; Ulas, Thomas; Ullrich, Sebastian; Ushijima, Toshikazu; Valencia, Alfonso; Vellenga, Edo; Vingron, Martin; Wallace, Chris; Wallner, Stefan; Walter, Jörn; Wang, Huating; Weber, Stephanie; Weiler, Nina; Weller, Andreas; Weng, Andrew; Wilder, Steven; Wiseman, Sam M; Wu, Angela R; Wu, Zhenguo; Xiong, Jieyi; Yamashita, Yasuhiro; Yang, Xinyi; Yap, Desmond Y; Yip, Kevin Y; Yip, Stephen; Yoo, Jae-Il; Zerbino, Daniel; Zipprich, Gideon
    The International Human Epigenome Consortium : A Blueprint for Scientific Collaboration and Discovery
    In: Cell Vol. 167 (2016) Nr. 5, pp. 1145 - 1149
    ISSN: 0092-8674
    Online Full Text: dx.doi.org/ (Open Access)
  • Kretzmer, Helene; Bernhart, Stephan H; Wang, Wei; Haake, Andrea; Weniger, Marc; Bergmann, Anke K; Betts, Matthew J; Carrillo-de-Santa-Pau, Enrique; Doose, Gero; Gutwein, Jana; Richter, Julia; Hovestadt, Volker; Huang, Bingding; Rico, Daniel; Jühling, Frank; Kolarova, Julia; Lu, Qianhao; Otto, Christian; Wagener, Rabea; Arnolds, Judith; Burkhardt, Birgit; Claviez, Alexander; Drexler, Hans G; Eberth, Sonja; Eils, Roland; Flicek, Paul; Haas, Siegfried; Hummel, Michael; Karsch, Dennis; Kerstens, Hinrik H D; Klapper, Wolfram; Kreuz, Markus; Lawerenz, Chris; Lenze, Dido; Loeffler, Markus; López, Cristina; MacLeod, Roderick A F; Martens, Joost H A; Kulis, Marta; Martín-Subero, José Ignacio; Möller, Peter; Nagel, Inga; Picelli, Simone; Vater, Inga; Rohde, Marius; Rosenstiel, Philip; Rosolowski, Maciej; Russell, Robert B; Schilhabel, Markus; Schlesner, Matthias; Stadler, Peter F; Szczepanowski, Monika; Trümper, Lorenz; Stunnenberg, Hendrik G; Küppers, Ralf; Ammerpohl, Ole; Lichter, Peter; Siebert, Reiner; Hoffmann, Steve; Radlwimmer, Bernhard
    DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control
    In: Nature Genetics Vol. 47 (2015) Nr. 11, pp. 1316 - 1325
    ISSN: 1061-4036; 1546-1718
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Loeffler, M.; Kreuz, M.; Haake, A.; Hasenclever, D.; Trautmann, H.; Arnold, C.; Winter, K.; Koch, K.; Klapper, W.; Scholtysik, R.; Rosolowski, M.; Hoffmann, S.; Ammerpohl, O.; Szczepanowski, M.; Herrmann, D.; Küppers, Ralf; Pott, C.; Siebert, R.
    Genomic and epigenomic co-evolution in follicular lymphomas
    In: Leukemia Vol. 29 (2015) Nr. 2, pp. 456 - 463
    ISSN: 1476-5551
    Online Full Text: dx.doi.org/
  • Oakes, C. C.; Seifert, Marc; Assenov, Y.; Gu, L.; Przekopowitz, M.; Ruppert, A. S.; Wang, Q.; Imbusch, C.; Serva, A.; Koser, S.; Brocks, D.; Lipka, D. B.; Bogatyrova, O.; Brors, B.; Weichenhan, D.; Rassenti, L. Z.; Kipps, T. J.; Mertens, D.; Zapatka, M.; Lichter, P.; Dohner, H.; Küppers, Ralf; Zenz, T.; Stilgenbauer, S.; Byrd, J. C.; Plass, C.
    Progressive Epigenetic Programming during B Cell Maturation Is Reflected in a Continuum of Epigenetic Disease Phenotypes in Chronic Lymphocytic Leukemia
    In: Blood Vol. 126 (2015) Nr. 23, pp. 2436
    ISSN: 0006-4971; 1528-0020
    Online Full Text: dx.doi.org/
  • Kulis, Marta; Merkel, Angelika; Heath, Simon; Queirós, Ana C.; Schuyler, Ronald P.; Castellano, Giancarlo; Beekman, Renée; Raineri, Emanuele; Esteve, Anna; Clot, Guillem; Verdaguer-Dot, Néria; Duran-Ferrer, Martí; Russiñol, Nuria; Vilarrasa-Blasi, Roser; Ecker, Simone; Pancaldi, Vera; Rico, Daniel; Agueda, Lidia; Blanc, Julie; Richardson, David; Clarke, Laura; Datta, Avik; Pascual, Marien; Agirre, Xabier; Prosper, Felipe; Alignani, Diego; Paiva, Bruno; Caron, Gersende; Fest, Thierry; Muench, Marcus O.; Fomin, Marina E.; Lee, Seung-Tae; Wiemels, Joseph L.; Valencia, Alfonso; Gut, Marta; Flicek, Paul; Stunnenberg, Hendrik G.; Siebert, Reiner; Küppers, Ralf; Gut, Ivo G.; Campo, Elías; Martín-Subero, José I.
    Whole-genome fingerprint of the DNA methylome during human B cell differentiation
    In: Nature Genetics Vol. 47 (2015) Nr. 7, pp. 746 - 756
    ISSN: 1061-4036; 1546-1718
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Küppers, Ralf
    A microRNA involved in the germinal center reaction
    In: Blood Vol. 124 (2014) Nr. 2, pp. 158 - 159
    ISSN: 1528-0020
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Salaverria, I.; Martin-Guerrero, I.; Wagener, R.; Kreuz, M.; Kohler, C. W.; Richter, J.; Pienkowska-Grela, B.; Adam, Patrick; Burkhardt, B.; Claviez, A.; Damm-Welk, C.; Drexler, H. G.; Hummel, Michael; Jaffe, E. S.; Küppers, Ralf; Lefebvre, C.; Lisfeld, J.; Lof̈fler, M.; Macleod,~R.~A.~F.; Nagel, I.; Oschlies, I.; Rosolowski, M.; Russell, R. B.; Rymkiewicz, G.; Schindler, D.; Schlesner, M.; Scholtysik, Rene; Schwaenen, C.; Spang, R.; Szczepanowski, M.; Trum̈per, L.; Vater, I.; Wessendorf, S.; Klapper, W.; Siebert, Reiner
    A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma
    In: Blood Vol. 123 (2014) Nr. 8, pp. 1187 - 1198
    ISSN: 1528-0020
    Online Full Text: dx.doi.org/
  • Kulis, Marta; Heath, Simon; Castellano, Giancarlo; Beekman, Renee; Merkel, Angelika; Raineri, Emanuele; Esteve, Anna; Queiros, AnaC; Clot, Guillem; Schuyler, Ronald; Ecker, Simone; Pancaldi, Vera; Rico, Daniel; Agueda, Lidia; Blanc, Julie; Richardson, David; Clarke, Laura; Datta, Avik; Russinol, Nuria; Pascual, Marien; Aguirre, Xavier; Prosper, Felipe; Alignani, Diego; Caron, Gersende; Fest, Thierry; Muench, MarcusO; Fomin, Marina; Lee, Seung-Tae; Wiemels, JosephL; Valencia, Alfonso; Gut, Marta; Flicek, Paul; Stunnenberg, HendrikG; Siebert, Reiner; Küppers, Ralf; Gut, IvoG; Campo, Elias; Martin-Subero, JoseI
    Characterization of the DNA Methylome during Human B-Cell Differentiation
    In: Blood Vol. 124 (2014) Nr. 21, pp. 4346
    ISSN: 0006-4971; 1528-0020
    Online Full Text
  • Küppers, Ralf; Dührsen, Ulrich; Hansmann, Martin-Leo
    Pathogenesis, diagnosis, and treatment of composite lymphomas
    In: The Lancet Oncology Vol. 15 (2014) Nr. 10, pp. e435 - 46
    ISSN: 1470-2045; 1474-5488
    Online Full Text: dx.doi.org/
  • Schneider, Markus; Szaumkessel, Marcin; Richter, Julia; Ammerpohl, Ole; Hansmann, Martin-Leo; Küppers, Ralf; Siebert, Reiner; Giefing, Maciej
    The PRDX2 gene is transcriptionally silenced and de novo methylated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma
    In: Blood Vol. 123 (2014) Nr. 23, pp. 3672 - 3674
    ISSN: 1528-0020; 0006-4971
    Online Full Text: dx.doi.org/
  • Bohle, V.; Döring, C.; Hansmann, M.-L.; Küppers, Ralf
    Role of early B-cell factor 1 (EBF1) in Hodgkin lymphoma
    In: Leukemia Vol. 27 (2013) Nr. 3, pp. 671 - 679
    ISSN: 1476-5551; 0887-6924
    Online Full Text: dx.doi.org/
  • Tiacci, Enrico; Döring, Claudia; Brune, Verena; Van Noesel, Carel J. M.; Klapper, Wolfram; Mechtersheimer, Gunhild; Falini, Brunangelo; Küppers, Ralf; Hansmann, Martin-Leo; Hansmann, M.-L.
    Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma
    In: Blood Vol. 120 (2012) Nr. 23, pp. 4609 - 4620
    ISSN: 0006-4971; 1528-0020
    Online Full Text: dx.doi.org/
  • Ammerpohl, O; Haake, A; Pellissery, S; Giefing, M; Richter, J; Balint, B; Kulis, M; Le, J; Bibikova, M; Drexler, H G; Seifert, Marc; Shaknovic, R; Korn, B; Küppers, Ralf; Martín-Subero, J I; Siebert, R
    Array-based DNA methylation analysis in classical Hodgkin lymphoma reveals new insights into the mechanisms underlying silencing of B cell-specific genes
    In: Leukemia Vol. 26 (2012) Nr. 1, pp. 185 - 188
    ISSN: 0887-6924; 1476-5551
    Online Full Text: dx.doi.org/
  • Adams, David; Altucci, Lucia; Antonarakis, Stylianos E; Ballesteros, Juan; Beck, Stephan; Bird, Adrian; Bock, Christoph; Boehm, Bernhard; Campo, Elias; Caricasole, Andrea; Dahl, Fredrik; Dermitzakis, Emmanouil T; Enver, Tariq; Esteller, Manel; Estivill, Xavier; Ferguson-Smith, Anne; Fitzgibbon, Jude; Flicek, Paul; Giehl, Claudia; Graf, Thomas; Grosveld, Frank; Guigo, Roderic; Gut, Ivo; Helin, Kristian; Jarvius, Jonas; Küppers, Ralf; Lehrach, Hans; Lengauer, Thomas; Lernmark, Åke; Leslie, David; Loeffler, Markus; Macintyre, Elizabeth; Mai, Antonello; Martens, Joost H A; Minucci, Saverio; Ouwehand, Willem H; Pelicci, Pier Giuseppe; Pendeville, Hèléne; Porse, Bo; Rakyan, Vardhman; Reik, Wolf; Schrappe, Martin; Schübeler, Dirk; Seifert, Martin; Siebert, Reiner; Simmons, David; Soranzo, Nicole; Spicuglia, Salvatore; Stratton, Michael; Stunnenberg, Hendrik G; Tanay, Amos; Torrents, David; Valencia, Alfonso; Vellenga, Edo; Vingron, Martin; Walter, Jörn; Willcocks, Spike
    BLUEPRINT to decode the epigenetic signature written in blood
    In: Nature Biotechnology Vol. 30 (2012) Nr. 3, pp. 224 - 226
    ISSN: 1087-0156; 1546-1696
    Online Full Text: dx.doi.org/
  • Johansson, Patricia; Klein-Hitpaß, Ludger; Scholtysik, René; Seifert, Marc; Jäger, Ulrich; Tschurtschenthaler, Gertraud; Dührsen, Ulrich; Küppers, Ralf; Dürig, Jan
    Combined SNP Microarray Based Genomic Mapping and Next Generation Transcriptome Sequencing Confirms the Presence of Somatic STAT3 Mutations and Identifies Novel Chromosomal Imbalances and Candidate Genes in T Large Granular Lymphocytic Leukemia (T-LGL)
    In: Blood Vol. 120 (2012) Nr. 21, pp. 3512
    ISSN: 0006-4971; 1528-0020
    Online Full Text: dx.doi.org/
  • Peveling-Oberhag, J.; Crisman, G.; Schmidt, A.; Döring, C.; Lucioni, M.; Arcaini, L.; Rattotti, S.; Hartmann, S.; Piiper, A.; Hofmann, W.-P.; Paulli, M.; Küppers, Ralf; Zeuzem, S.; Hansmann, M.-L.
    Dysregulation of global microRNA expression in splenic marginal zone lymphoma and influence of chronic hepatitis C virus infection
    In: Leukemia Vol. 26 (2012) Nr. 7, pp. 1654 - 1662
    ISSN: 0887-6924; 1476-5551
    Online Full Text: dx.doi.org/
  • Richter, Julia; Schlesner, Matthias; Hoffmann, Steve; Kreuz, Markus; Leich, Ellen; Burkhardt, Birgit; Rosolowski, MacIej; Ammerpohl, Ole; Wagener, Rabea; Bernhart, Stephan H.; Lenze, Dido; Szczepanowski, Monika; Paulsen, Maren; Lipinski, Simone; Russell, Robert B.; Adam-Klages, Sabine; Apic, Gordana; Claviez, Alexander; Hasenclever, Dirk; Hovestadt, Volker; Hornig, Nadine; Korbel, Jan O.; Kube, Dieter; Langenberger, David; Lawerenz, Chris; Lisfeld, Jasmin; Meyer, Katharina; Picelli, Simone; Pischimarov, Jordan; Radlwimmer, Bernhard; Rausch, Tobias; Rohde, Marius; Schilhabel, Markus; Scholtysik, René; Spang, Rainer; Trautmann, Heiko; Zenz, Thorsten; Borkhardt, Arndt; Drexler, Hans G.; Möller, Peter; MacLeod, Roderick A. F.; Pott, Christiane; Schreiber, Stefan; Trümper, Lorenz; Loeffler, Markus; Stadler, Peter F.; Lichter, Peter; Eils, Roland; Küppers, Ralf; Hummel, Michael; Klapper, Wolfram; Rosenstiel, Philip; Rosenwald, Andreas; Brors, Benedikt; Siebert, Reiner
    Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing
    In: Nature Genetics Vol. 44 (2012) Nr. 12, pp. 1316 - 1320
    ISSN: 1061-4036; 1546-1718
    Online Full Text: dx.doi.org/
  • Küppers, Ralf
    CCR7 & lymphotoxin in lymphoma niche
    In: Blood Vol. 118 (2011) Nr. 4, pp. 831 - 832
    ISSN: 0006-4971; 1528-0020
    Online Full Text: dx.doi.org/
  • Deckert, M.; Engert, A.; Brück, W.; Ferreri, A.J.M.; Finke, J.; Illerhaus, G.; Klapper, W.; Korfel, A.; Küppers, Ralf; Maarouf, M.; Montesinos-Rongen, M.; Paulus, W.; Schlegel, U.; Lassmann, H.; Wiestler, O.D.; Siebert, R.; Deangelis, L.M.
    Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma
    In: Leukemia Vol. 25 (2011) Nr. 12, pp. 1797 - 1807
    ISSN: 0887-6924; 1476-5551
    Online Full Text: dx.doi.org/
  • Küppers, Ralf
    NPAT mutations in Hodgkin lymphoma
    In: Blood Vol. 118 (2011) Nr. 3, pp. 484 - 485
    ISSN: 0006-4971; 1528-0020
    Online Full Text: dx.doi.org/
  • Salaverria, Itziar; Philipp, Claudia; Oschlies, Ilske; Kohler, Christian W.; Kreuz, Markus; Szczepanowski, Monika; Burkhardt, Birgit; Trautmann, Heiko; Gesk, Stefan; Andrusiewicz, Miroslaw; Berger, Hilmar; Fey, Miriam; Harder, Lana; Hasenclever, Dirk; Hummel, Michael; Loeffler, Markus; Mahn, Friederike; Martin-Guerrero, Idoia; Pellissery, Shoji; Pott, Christiane; Pfreundschuh, Michael; Reiter, Alfred; Richter, Julia; Rosolowski, Maciej; Schwaenen, Carsten; Stein, Harald; Trümper, Lorenz; Wessendorf, Swen; Spang, Rainer; Küppers, Ralf; Klapper, Wolfram; Siebert, Reiner
    Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults
    In: Blood Vol. 118 (2011) Nr. 1, pp. 139 - 147
    ISSN: 0006-4971; 1528-0020
    Online Full Text: dx.doi.org/
  • Zenz, Thorsten; Mertens, Daniel; Küppers, Ralf; Döhner, Hartmut; Stilgenbauer, Stephan
    From pathogenesis to treatment of chronic lymphocytic leukaemia
    In: Nature Reviews Cancer Vol. 10 (2010) Nr. 1, pp. 37 - 50
    ISSN: 1474-175X; 1474-1768
    Online Full Text: dx.doi.org/
  • Küppers, Ralf
    Genomic imbalances in Hodgkin lymphoma
    In: Blood Vol. 116 (2010) Nr. 3, pp. 309 - 311
    ISSN: 1528-0020; 0006-4971
    Online Full Text: dx.doi.org/ (Open Access)
  • Stanelle, Jens; Döring, Claudia; Hansmann, Martin-Leo; Küppers, Ralf
    Mechanisms of aberrant GATA3 expression in classical Hodgkin lymphoma and its consequences for the cytokine profile of Hodgkin and Reed/Sternberg cells
    In: Blood Vol. 116 (2010) Nr. 20, pp. 4202 - 4211
    ISSN: 1528-0020; 0006-4971
    Online Full Text: dx.doi.org/ (Open Access)
  • Montesinos-Rongen, Manuel; Schmitz, Roland; Brunn, Anna; Gesk, Stefan; Richter, Julia; Hong, Ke; Wiestler, Otmar D.; Siebert, Reiner; Küppers, Ralf; Deckert, Martina
    Mutations of CARD11 but not TNFAIP3 may activate the NF-κB pathway in primary CNS lymphoma
    In: Acta Neuropathologica Vol. 120 (2010) Nr. 4, pp. 529 - 535
    ISSN: 1432-0533; 0001-6322
    Online Full Text: dx.doi.org/
  • Nückel, Holger; Switala, Magdalena; Sellmann, Ludger; Horn, Peter; Dürig, Jan; Dührsen, Ulrich; Küppers, Ralf; Grosse-Wilde, Hans; Rebmann, Vera
    The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia
    In: Leukemia Vol. 24 (2010) Nr. 6, pp. 1152 - 1159
    ISSN: 0887-6924; 1476-5551
    Online Full Text: dx.doi.org/
Read more