ZMB Member Ralf Küppers

ZMB Member
Ralf Küppers

Next ZMB-Member
Ralf Küppers portrait
© UKE/Küppers

Prof. Dr. Ralf Küppers

Director of:

Institute of Cell Biology (Tumor Research)

University Hospital Essen
Virchowstr. 173
45122 Essen

Research Overview

B lymphocytes represent the white blood cells that produce antibodies and that play an important role in immune responses against foreign antigens (e.g. bacteria). In rare instances, B lymphocytes may undergo malignant transformation and become tumour cells. Such tumours are called B cell lymphomas or leukemias. The main research topics of the group are:

  • Investigation of B cell differentiation and function in the human
  • The interplay of B cells with viruses (EBV, HCV, HIV)
  • Pathogenesis of human B cell lymphomas, in particular Hodgkin lymphoma

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Selected Publications

    Journal articles

  • Berg, Victoria; Lollies, Anna; Schneider, Markus; Johansson, Patricia; Weniger, Marc A.; Albertini, Emma; Facchetti, Fabio; Ascani, Stefano; Moawia, Abubakar; Bens, Susanne; Fischer, Anja; Siebert, Reiner; Klapper, Wolfram; Lorenzi, Luisa; Tiacci, Enrico; Hartmann, Sylvia; Budeus, Bettina; Hansmann, Martin-Leo; Küppers, Ralf
    Common origin and somatic mutation patterns of composite lymphomas and leukemias
    In: Leukemia, Vol. 39, 2025, Nr. 8, pp. 1960 – 1971
    DOI (Open Access)
  • Rausch, Tobias; Schäfer, Hendrik; Bein, Julia; Mölder, Felix; Beeck, Lilian Kara; Kölsch, Bernd; Borchert, Sabrina; Benes, Vladimir; Halbsguth, Teresa; Brunnberg, Uta; Oellerich, Thomas; Tousseyn, Thomas; Ponzoni, Maurilio; Köster, Johannes; Hansmann, Martin-Leo; Küppers, Ralf; Hartmann, Sylvia
    Genetic lesions in nodular lymphocyte-predominant Hodgkin lymphoma and T cell/histiocyte-rich large B-cell lymphoma identified by whole genome sequencing
    In: Leukemia, Vol. 39, 2025, Nr. 9, pp. 2215 – 2225
    DOI (Open Access)
  • Glaser, Selina; Fischer, Anja; Martínez-Manjón, Juan Emilio; López, Cristina; Kretzmer, Helene; Burkhardt, Birgit; Hübschmann, Daniel; Hummel, Michael; Klapper, Wolfram; Kolarova, Julia; Kreuz, Markus; Ott, German; Radlwimmer, Bernhard; Rosolowski, Maciej; Schlesner, Matthias; Rosenwald, Andreas; Stilgenbauer, Stephan; Wagener, Rabea; Zwir, Igor; Trümper, Lorenz; Küppers, Ralf; Lichter, Peter; Ammerpohl, Ole; del Val, Coral; Siebert, Reiner; ICGC MMML-Seq consortium
    Subgrouping germinal center-derived B-cell lymphomas based on machine learning-deduced DNA methylation modules
    In: Leukemia, Vol. 39, 2025, Nr. 4, pp. 967 – 971
    DOI (Open Access)
  • Weischenfeldt, Joachim; Beroukhim, Rameen; Campbell, Peter J.; Küppers, Ralf; Schadendorf, Dirk
    Author Correction : Patterns of somatic structural variation in human cancer genomes
    In: Nature, Vol. 614, 2023, Nr. 7948, pp. E38
    DOI (Open Access)
  • Weischenfeldt, Joachim; Beroukhim, Rameen; Martincorena, Iñigo; Küppers, Ralf
    Author Correction : Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
    In: Nature, Vol. 614, 2023, pp. E40
    DOI (Open Access)
  • Gerstung, Moritz; Jolly, Clemency; Leshchiner, Ignaty; Küppers, Ralf; Schadendorf, Dirk
    Author Correction : The evolutionary history of 2,658 cancers
    In: Nature, Vol. 614, 2023, E42
    DOI (Open Access)
  • Calabrese, Claudia; Brazma, Alvis; Brooks, Angela N.; Rätsch, Gunnar; Küppers, Ralf; Schadendorf, Dirk
    Author Correction : Genomic basis for RNA alterations in cancer
    In: Nature, Vol. 614, 2023, Nr. 7948, pp. E37
    DOI (Open Access)
  • Yakneen, Sergei; M. Waszak, Sebastian; Korbel, Jan O.; Küppers, Ralf; Schadendorf, Dirk
    Author Correction : Butler enables rapid cloud-based analysis of thousands of human genomes
    In: Nature Biotechnology, Vol. 41, 2023, Nr. 4, pp. 577
    DOI (Open Access)
  • Alexandrov, Ludmil B.; Kim, Jaegil; Haradhvala, Nicholas J.; Rozen, Steven G.; Stratton, Michael R.; Küppers, Ralf; Schadendorf, Dirk
    Author Correction: : The repertoire of mutational signatures in human cancer
    In: Nature, Vol. 614, 2023, pp. E41
    DOI (Open Access)
  • Cortés-Ciriano, Isidro; Küppers, Ralf; Schadendorf, Dirk; Park, Peter J.
    Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
    In: Nature Genetics, Vol. 55, 2023, Nr. 6, 1076
    DOI (Open Access)
  • Akdemir, Kadir C.; Küppers, Ralf; Schadendorf, Dirk; Futreal, P. Andrew
    Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
    In: Nature Genetics, Vol. 55, 2023, Nr. 6, pp. 1079
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk
    Author Correction: Pan-cancer analysis of whole genomes
    In: Nature, Vol. 614, 2023, Nr. 7948, pp. E39
    DOI (Open Access)
  • Cortés-Ciriano, Isidro; Küppers, Ralf; Schadendorf, Dirk; Park, Peter J.
    Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
    In: Nature Genetics, Vol. 52, 2023, pp. 331 – 341
    DOI (Open Access)
  • Akdemir, Kadir C.; Küppers, Ralf; Schadendorf, Dirk; Futreal, P. Andrew
    Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
    In: Nature Genetics, Vol. 52, 2023, Nr. 3, pp. 294 – 305
    DOI (Open Access)
  • Zapatka, Marc; Küppers, Ralf; Schadendorf, Dirk; Lichter, Peter
    The landscape of viral associations in human cancers
    In: Nature Genetics, 2023, Nr. 52, pp. 320 – 330
    DOI (Open Access)
  • Alexandrov, Ludmil B.; Kim, Jaegil; Haradhvala, Nicholas J.; Rozen, Steven G.; Stratton, Michael R.; Küppers, Ralf; Schadendorf, Dirk
    The repertoire of mutational signatures in human cancer
    In: Nature, Vol. 578, 2023, Nr. 7793, pp. 94 – 101
    DOI (Open Access)
  • Schleussner, Nikolai; Cauchy, Pierre; Franke, Vedran; Giefing, Maciej; Fornes, Oriol; Vankadari, Naveen; Assi, Salam A.; Costanza, Mariantonia; Weniger, Marc A.; Akalin, Altuna; Anagnostopoulos, Ioannis; Bukur, Thomas; Casarotto, Marco G.; Damm, Frederik; Daumke, Oliver; Edginton-White, Benjamin; Gebhardt, J. Christof M.; Grau, Michael; Grunwald, Stephan; Hansmann, Martin-Leo; Hartmann, Sylvia; Huber, Lionel; Kärgel, Eva; Lusatis, Simone; Noerenberg, Daniel; Obier, Nadine; Pannicke, Ulrich; Fischer, Anja; Reisser, Anja; Rosenwald, Andreas; Schwarz, Klaus; Sundararaj, Srinivasan; Weilemann, Andre; Winkler, Wiebke; Xu, Wendan; Lenz, Georg; Rajewsky, Klaus; Wasserman, Wyeth W.; Cockerill, Peter N.; Scheidereit, Claus; Siebert, Reiner; Küppers, Ralf; Grosschedl, Rudolf; Janz, Martin; Bonifer, Constanze; Mathas, Stephan
    Transcriptional reprogramming by mutated IRF4 in lymphoma
    In: Nature Communications, Vol. 14, 2023, Nr. 1, 6947
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Bristow, Robert G.; Boutros, Paul C.; PCAWG Consortium
    Author Correction : Divergent mutational processes distinguish hypoxic and normoxic tumours
    In: Nature Communications, Vol. 13, 2022, 7569
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Shuai, Shimin; Stein, Lincoln D.; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Consortium
    Author Correction : Combined burden and functional impact tests for cancer driver discovery using DriverPower
    In: Nature Communications, Vol. 13, 2022, 7571
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Stein, Lincoln D.; PCAWG Consortium
    Author Correction : A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
    In: Nature Communications, Vol. 13, 2022, 7573
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Creighton, Chad J.; PCAWG Consortium
    Author Correction : High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
    In: Nature Communications, Vol. 13, 2022, 7572
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Macintyre, Geoff; PCAWG Consortium
    Author Correction : Inferring structural variant cancer cell fraction
    In: Nature Communications, Vol. 13, 2022, 7568
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Morris, Quaid D.; PCAWG Consortium
    Author Correction : Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
    In: Nature Communications, Vol. 13, 2022, 7567
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Feuerbach, Lars; PCAWG Consortium
    Author Correction : Genomic footprints of activated telomere maintenance mechanisms in cancer
    In: Nature Communications, Vol. 13, 2022, 7574
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Reimand, Jüri; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Consortium
    Author Correction : Integrative pathway enrichment analysis of multivariate omics data
    In: Nature Communications, Vol. 13, 2022, 7570
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Reimand, Jüri; PCAWG Consortium
    Author Correction : Pathway and network analysis of more than 2500 whole cancer genomes
    In: Nature Communications, Vol. 13, 2022, 7566
    DOI (Open Access)
  • Johansson, Patricia; Eckstein, Anja; Küppers, Ralf
    The Biology of Ocular Adnexal Marginal Zone Lymphomas
    In: Cancers, Vol. 14, 2022, Nr. 5, 1264
    DOI, Online Full Text (Open Access)
  • Montesinos-Rongen, Manuel; Brunn, Anna; Sanchez-Ruiz, Monica; Küppers, Ralf; Siebert, Reiner; Deckert, Martina
    Impact of a faulty germinal center reaction on the pathogenesis of primary diffuse large b cell lymphoma of the central nervous system
    In: Cancers, Vol. 13, 2021, Nr. 24, 6334
    DOI (Open Access)
  • Weniger, Marc; Küppers, Ralf
    Molecular biology of Hodgkin lymphoma
    In: Leukemia, Vol. 35, 2021, Nr. 4, pp. 968 – 981
    DOI (Open Access)
  • Hübschmann, Daniel; Kleinheinz, Kortine; Wagener, Rabea; Bernhart, Stephan H.; López, Cristina; Toprak, Umut H.; Sungalee, Stephanie; Ishaque, Naveed; Kretzmer, Helene; Kreuz, Markus; Waszak, Sebastian M.; Paramasivam, Nagarajan; Ammerpohl, Ole; Aukema, Sietse M.; Beekman, Renée; Bergmann, Anke K.; Bieg, Matthias; Binder, Hans; Borkhardt, Arndt; Borst, Christoph; Brors, Benedikt; Bruns, Philipp; Carrillo de Santa Pau, Enrique; Claviez, Alexander; Doose, Gero; Haake, Andrea; Karsch, Dennis; Haas, Siegfried; Hansmann, Martin-Leo; Hoell, Jessica I.; Hovestadt, Volker; Huang, Bingding; Hummel, Michael; Jäger-Schmidt, Christina; Kerssemakers, Jules N. A.; Korbel, Jan O.; Kube, Dieter; Lawerenz, Chris; Lenze, Dido; Martens, Joost H. A.; Ott, German; Radlwimmer, Bernhard; Reisinger, Eva; Richter, Julia; Rico, Daniel; Rosenstiel, Philip; Rosenwald, Andreas; Schillhabel, Markus; Stilgenbauer, Stephan; Stadler, Peter F.; Martín-Subero, José I.; Szczepanowski, Monika; Warsow, Gregor; Weniger, Marc; Zapatka, Marc; Valencia, Alfonso; Stunnenberg, Hendrik G.; Lichter, Peter; Möller, Peter; Loeffler, Markus; Eils, Roland; Klapper, Wolfram; Hoffmann, Steve; Trümper, Lorenz; Küppers, Ralf; Schlesner, Matthias; Siebert, Reiner
    Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas
    In: Leukemia, Vol. 35, 2021, pp. 2002 – 2016
    DOI (Open Access)
  • Küppers, Ralf
    Sugar-modified B-cell receptors in DLBCL
    In: Blood, Vol. 138, 2021, Nr. 17, pp. 1512 – 1514
    DOI (Open Access)
  • Cao, Yingying; Kitanovski, Simo; Küppers, Ralf; Hoffmann, Daniel
    UMI or not UMI, that is the question for scRNA-seq zero-inflation
    In: Nature Biotechnology, Vol. 39, 2021, Nr. 2, pp. 158 – 159
    DOI, Online Full Text (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Stein, Lincoln D.; PCAWG Consortium
    A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
    In: Nature Communications, Vol. 11, 2020, 728
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk
    Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
    In: Nature Communications, Vol. 11, 2020, Nr. 1, pp. 6232
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Shuai, Shimin; Stein, Lincoln D.
    Combined burden and functional impact tests for cancer driver discovery using DriverPower
    In: Nature Communications, Vol. 11, 2020, 734
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Bristow, Robert G.; Boutros, Paul C.; PCAWG Consortium
    Divergent mutational processes distinguish hypoxic and normoxic tumours
    In: Nature Communications, Vol. 11, 2020, 737
    DOI (Open Access)
  • Nadeu, Ferran; Martin-Garcia, David; Clot, Guillem; Díaz-Navarro, Ander; Duran-Ferrer, Martí; Navarro, Alba; Vilarrasa-Blasi, Roser; Kulis, Marta; Royo, Romina; Gutiérrez-Abril, Jesús; Valdés-Mas, Rafael; López, Cristina; Chapaprieta, Vicente; Puiggros, Montserrat; Castellano, Giancarlo; Costa, Dolors; Aymerich, Marta; Jares, Pedro; Espinet, Blanca; Muntañola, Ana; Ribera-Cortada, Inmaculada; Siebert, Reiner; Colomer, Dolors; Torrents, David; Gine, Eva; López-Guillermo, Armando; Küppers, Ralf; Martin-Subero, Jose I.; Puente, Xose S.; Beà, Sílvia; Campo, Elias
    Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes
    In: Blood, Vol. 136, 2020, Nr. 12, pp. 1419 – 1432
    DOI, Online Full Text (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Feuerbach, Lars; PCAWG Consortium
    Genomic footprints of activated telomere maintenance mechanisms in cancer
    In: Nature Communications, Vol. 11, 2020, 733
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Creighton, Chad J.; PCAWG Consortium
    High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
    In: Nature Communications, Vol. 11, 2020, 736
    DOI (Open Access)
  • Johansson, Patricia; Klein-Hitpaß, Ludger; Budeus, Bettina; Kuhn, Matthias; Lauber, Chris; Seifert, Michael; Roeder, Ingo; Pförtner, Roman; Stuschke, Martin; Dührsen, Ulrich; Eckstein, Anja; Dürig, Jan; Küppers, Ralf
    Identifying genetic lesions in ocular adnexal extranodal marginal zone lymphomas of the malt subtype by whole genome, whole exome and targeted sequencing
    In: Cancers, Vol. 12, 2020, Nr. 4, 986
    DOI, Online Full Text (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Cmero, Marek; Macintyre, Geoff; PCAWG Consortium
    Inferring structural variant cancer cell fraction
    In: Nature Communications, Vol. 11, 2020, 730
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Reimand, Jüri; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Consortium
    Integrative pathway enrichment analysis of multivariate omics data
    In: Nature Communications, Vol. 11, 2020, 735
    DOI (Open Access)
  • Thurner, Lorenz; Hartmann, Sylvia; Fadle, Natalie; Regitz, Evi; Kemele, Maria; Kim, Yoo-Jin; Bohle, Rainer Maria; Nimmesgern, Anna; von Müller, Lutz; Kempf, Volkhard A. J.; Weniger, Marc; Neumann, Frank; Schneider, Nadine; Vornanen, Martine; Sundström, Christer; de Leval, Laurence; Engert, Andreas; Eichenauer, Dennis A.; Küppers, Ralf; Preuss, Klaus-Dieter; Hansmann, Martin-Leo; Pfreundschuh, Michael
    Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma
    In: Nature Communications, Vol. 11, 2020, Nr. 1, pp. 2465
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium; et al.
    Pan-cancer analysis of whole genomes
    In: Nature, Vol. 578, 2020, Nr. 7793, pp. 82 – 93
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk
    Pathway and network analysis of more than 2500 whole cancer genomes
    In: Nature Communications, Vol. 11, 2020, 729
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Morris, Quaid D.; PCAWG Consortium
    Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
    In: Nature Communications, Vol. 11, 2020, 731
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk
    Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
    In: Nature Communications, Vol. 11, 2020, Nr. 1, pp. 4748
    DOI (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; PCAWG Tumour Subtypes and Clinical Translation; PCAWG Consortium
    Sex differences in oncogenic mutational processes
    In: Nature Communications, Vol. 11, 2020, Nr. 1, pp. 4330
    DOI (Open Access)
  • Bankov, Katrin; Döring, Claudia; Ustaszewski, Adam; Giefing, Maciej; Herling, Marco; Cencioni, Chiara; Spallotta, Francesco; Gaetano, Carlo; Küppers, Ralf; Hansmann, Martin-Leo; Hartmann, Sylvia
    Fibroblasts in nodular sclerosing classical Hodgkin lymphoma are defined by a specific phenotype and protect tumor cells from brentuximab-Vedotin induced injury
    In: Cancers, Vol. 11, 2019, Nr. 11, Article-No: 1687
    DOI (Open Access)
  • López, Cristina; Kleinheinz, Kortine; Aukema, Sietse M.; Rohde, Marius; Bernhart, Stephan H.; Hübschmann, Daniel; Wagener, Rabea; Toprak, Umut H.; Raimondi, Francesco; Kreuz, Markus; Waszak, Sebastian M.; Huang, Zhiqin; Sieverling, Lina; Paramasivam, Nagarajan; Seufert, Julian; Sungalee, Stephanie; Russell, Robert B.; Bausinger, Julia; Kretzmer, Helene; Ammerpohl, Ole; Bergmann, Anke K.; Binder, Hans; Borkhardt, Arndt; Brors, Benedikt; Claviez, Alexander; Doose, Gero; Feuerbach, Lars; Haake, Andrea; Hansmann, Martin-Leo; Hoell, Jessica; Hummel, Michael; Korbel, Jan O.; Lawerenz, Chris; Lenze, Dido; Radlwimmer, Bernhard; Richter, Julia; Rosenstiel, Philip; Rosenwald, Andreas; Schilhabel, Markus B.; Stein, Harald; Stilgenbauer, Stephan; Stadler, Peter F.; Szczepanowski, Monika; Weniger, Marc; Zapatka, Marc; Eils, Roland; Lichter, Peter; Loeffler, Markus; Möller, Peter; Trümper, Lorenz; Klapper, Wolfram; Wagner, Susanne; Richter, Gesine; Eils, Jürgen; Kerssemakers, Jules; Jaeger-Schmidt, Christina; Scholz, Ingrid; Borst, Christoph; Braulke, Friederike; Dreyling, Martin; Eberth, Sonja; Einsele, Hermann; Frickhofen, Norbert; Haas, Siegfried; Karsch, Dennis; Klepl, Nicole; Kneba, Michael; Lisfeld, Jasmin; Mantovani-Löffler, Luisa; Ott, German; Stadler, Christina; Staib, Peter; Zenz, Thorsten; Kube, Dieter; Kostezka, Ulrike; Binder, Vera; Leich, Ellen; Nagel, Inga; Pischimariov, Jordan; Schreiber, Stefan; Vater, Inga; Hopp, Lydia; Langenberger, David; Rosolowski, Maciej; Hoffmann, Steve; Küppers, Ralf; Burkhardt, Birgit; Schlesner, Matthias; Siebert, Reiner
    Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma
    In: Nature Communications, Vol. 10, 2019, Nr. 1, pp. 1459
    DOI (Open Access)
  • Hüllein, Jennifer; Słabicki, Mikołaj; Rosolowski, Maciej; Jethwa, Alexander; Habringer, Stefan; Tomska, Katarzyna; Kurilov, Roma; Lu, Junyan; Scheinost, Sebastian; Wagener, Rabea; Huang, Zhiqin; Lukas, Marina; Yavorska, Olena; Helfrich, Hanne; Scholtysik, René; Bonneau, Kyle; Tedesco, Donato; Küppers, Ralf; Klapper, Wolfram; Pott, Christiane; Stilgenbauer, Stephan; Burkhardt, Birgit; Löffler, Markus; Trümper, Lorenz H.; Hummel, Michael; Brors, Benedikt; Zapatka, Marc; Siebert, Reiner; Kreuz, Markus; Keller, Ulrich; Huber, Wolfgang; Zenz, Thorsten
    MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma
    In: Cancer Research, Vol. 79, 2019, Nr. 12, pp. 3125 – 3138
    DOI (Open Access)
  • Goncharova, Olga; Flinner, Nadine; Bein, Julia; Döring, Claudia; Donnadieu, Emmanuel; Rikirsch, Sandy; Herling, Marco; Küppers, Ralf; Hansmann, Martin-Leo; Hartmann, Sylvia
    Migration properties distinguish tumor cells of classical hodgkin lymphoma from anaplastic large cell lymphoma cells
    In: Cancers, Vol. 11, 2019, Nr. 10, pp. 1484
    DOI (Open Access)
  • Lollies, Anna; Hartmann, Sylvia; Schneider, Markus; Bracht, Thilo; Weiß, A.L.; Arnolds, Judith; Klein-Hitpaß, Ludger; Sitek, Barbara; Hansmann, Martin Leo; Küppers, Ralf; Weniger, Marc
    An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma
    In: Leukemia, Vol. 32, 2018, Nr. 1, pp. 92 – 101
    DOI
  • Tucci, Felicia A.; Kitanovski, Simo; Johansson, Patricia; Klein-Hitpaß, Ludger; Kahraman, Alisan; Dürig, Jan; Hoffmann, Daniel; Küppers, Ralf
    Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individuals
    In: Blood, Vol. 131, 2018, Nr. 5, pp. 546 – 557
    DOI (Open Access)
  • Küppers, Ralf; Stevenson, Freda K.
    Critical influences on the pathogenesis of follicular lymphoma
    In: Blood, Vol. 131, 2018, Nr. 21, pp. 2297 – 2306
    DOI (Open Access)
  • Wagener, Rabea; López, Cristina; Kleinheinz, Kortine; Bausinger, Julia; Aukema, Sietse M.; Nagel, Inga; Toprak, Umut H.; Seufert, Julian; Altmüller, Janine; Thiele, Holger; Schneider, Christof; Kolarova, Julia; Park, Jeongbin; Hübschmann, Daniel; Murga Penas, Eva M.; Drexler, Hans G.; Attarbaschi, Andishe; Hovland, Randi; Kjeldsen, Eigil; Kneba, Michael; Kontny, Udo; de Leval, Laurence; Nürnberg, Peter; Oschlies, Ilske; Oscier, David; Schlegelberger, Brigitte; Stilgenbauer, Stephan; Wössmann, Wilhelm; Schlesner, Matthias; Burkhardt, Birgit; Klapper, Wolfram; Jaffe, Elaine S.; Küppers, Ralf; Siebert, Reiner
    IG-MYC⁺ neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas
    In: Blood, Vol. 132, 2018, Nr. 21, pp. 2280 – 2285
    DOI (Open Access)
  • Oakes, Christopher C; Seifert, Marc; Assenov, Yassen; Gu, Lei; Przekopowitz, Martina; Ruppert, Amy S; Wang, Qi; Imbusch, Charles D; Serva, Andrius; Koser, Sandra D; Brocks, David; Lipka, Daniel B; Bogatyrova, Olga; Weichenhan, Dieter; Brors, Benedikt; Rassenti, Laura; Kipps, Thomas J; Mertens, Daniel; Zapatka, Marc; Lichter, Peter; Döhner, Hartmut; Küppers, Ralf; Zenz, Thorsten; Stilgenbauer, Stephan; Byrd, John C; Plass, Christoph
    DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia
    In: Nature Genetics, Vol. 48, 2016, Nr. 3, pp. 253 – 264
    DOI, Online Full Text (Open Access)
  • Mansouri, Larry; Noerenberg, Daniel; Young, Emma; Mylonas, Elena; Abdulla, Maysaa; Frick, Mareike; Asmar, Fazila; Ljungström, Viktor; Schneider, Markus; Yoshida, Kenichi; Skaftason, Aron; Pandzic, Tatjana; Gonzalez, Blanca; Tasidou, Anna; Waldhueter, Nils; Rivas-Delgado, Alfredo; Angelopoulou, Maria; Ziepert, Marita; Arends, Christopher Maximilian; Couronné, Lucile; Lenze, Dido; Baldus, Claudia D; Bastard, Christian; Okosun, Jessica; Fitzgibbon, Jude; Dörken, Bernd; Drexler, Hans G; Roos-Weil, Damien; Schmitt, Clemens A; Munch-Petersen, Helga D; Zenz, Thorsten; Hansmann, Martin-Leo; Strefford, Jonathan C; Enblad, Gunilla; Bernard, Olivier A; Ralfkiaer, Elisabeth; Erlanson, Martin; Korkolopoulou, Penelope; Hultdin, Magnus; Papadaki, Theodora; Grønbæk, Kirsten; Lopez-Guillermo, Armando; Ogawa, Seishi; Küppers, Ralf; Stamatopoulos, Kostas; Stavroyianni, Niki; Kanellis, George; Rosenwald, Andreas; Campo, Elias; Amini, Rose-Marie; Ott, German; Vassilakopoulos, Theodoros P; Hummel, Michael; Rosenquist, Richard; Damm, Frederik
    Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma
    In: Blood, Vol. 128, 2016, Nr. 23, pp. 2666 – 2670
    DOI (Open Access)
  • Hartmann, S; Schuhmacher, B; Rausch, T; Fuller, L; Döring, C; Weniger, Marc; Lollies, A; Weiser, C; Thurner, L; Rengstl, B; Brunnberg, U; Vornanen, M; Pfreundschuh, M; Benes, V; Küppers, Ralf; Newrzela, S; Hansmann, M-L
    Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphoma
    In: Leukemia, Vol. 30, 2016, Nr. 4, pp. 844 – 853
    DOI
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    Combined SNP Microarray Based Genomic Mapping and Next Generation Transcriptome Sequencing Confirms the Presence of Somatic STAT3 Mutations and Identifies Novel Chromosomal Imbalances and Candidate Genes in T Large Granular Lymphocytic Leukemia (T-LGL)
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    Mutations of CARD11 but not TNFAIP3 may activate the NF-κB pathway in primary CNS lymphoma
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    The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia
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