ZMB Member Ulf Dittmer

ZMB Member
Ulf Dittmer

Next ZMB-Member
Ulf Dittmer
© UKE/U.Dittmer

Prof. Dr. Ulf Dittmer

Director of:

Institute of Virology

University Hospital Essen
Hufelandstr. 55
45147 Essen

Research Overview

  1. Persistent viral infections
  2. Innate immunity to retroviruses
  3. Basics of cellular and molecular immune defense mechanisms
  4. Immune regulation in retrovirus infections
  5. Immunotherapy for retroviral infections and virus-induced tumors
  6. Development of vaccines against retroviruses
  7. Antiviral activity of interferons
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Selected Publications

    Journal articles

  • Stupia, Simone; Heeke, Christina; Brüggemann, Alicia; Zaremba-Montenari, Anne; Thier, Beatrice; Kretz, Julia; Sucker, Antje; Philip, Manuel; Zelinskyy, Gennadiy; Ferrone, Soldano; Rösch, Alexander; Horn, Susanne; Hadaschik, Eva; Schadendorf, Dirk; Trilling, Mirko; Dittmer, Ulf; Griewank, Klaus; Zhao, Fang; Paschen, Annette
    HLA class II loss and JAK1/2 deficiency coevolve in melanoma leading to CD4 T cell and IFNγ cross-resistance
    In: Clinical Cancer Research Vol. 29 (2023) Nr. 15, pp. 2894 - 2907
    Online Full Text: dx.doi.org/
  • Dewald, Felix; Pirkl, Martin; Paluschinski, Martha; Kühn, Joachim; Elsner, Carina; Schulte, Bianca; Knüfer, Jacqueline; Ahmadov, Elvin; Schlotz, Maike; Oral, Göksu; Bernhard, Michael; Michael, Mark; Luxenburger, Maura; Andrée, Marcel; Hennies, Marc Tim; Hafezi, Wali; Müller, Marlin Maybrit; Kümpers, Philipp; Risse, Joachim; Kill, Clemens; Manegold, Randi Katrin; von Frantzki, Ute; Richter, Enrico; Emmert, Dorian; Monzon-Posadas, Werner O.; Gräff, Ingo; Kogej, Monika; Büning, Antonia; Baum, Maximilian; Teipel, Finn; Mochtarzadeh, Babak; Wolff, Martin; Gruell, Henning; Di Cristanziano, Veronica; Burst, Volker; Streeck, Hendrik; Dittmer, Ulf; Ludwig, Stephan; Timm, Jörg; Klein, Florian
    Impaired humoral immunity to BQ.1.1 in convalescent and vaccinated patients
    In: Nature Communications Vol. 14 (2023) Nr. 1, 2835
    Online Full Text: dx.doi.org/ (Open Access)
  • Zehner, Matthias; Alt, Mira; Ashurov, Artem; Goldsmith, Jory A.; Spies, Rebecca; Weiler, Nina; Lerma, Justin; Gieselmann, Lutz; Stöhr, Dagmar; Gruell, Henning; Schultz, Eric P.; Kreer, Christoph; Schlachter, Linda; Janicki, Hanna; Laib Sampaio, Kerstin; Stegmann, Cora; Nemetchek, Michelle D.; Dähling, Sabrina; Ullrich, Leon; Dittmer, Ulf; Witzke, Oliver; Koch, Manuel; Ryckman, Brent J.; Lotfi, Ramin; McLellan, Jason S.; Krawczyk, Adalbert; Sinzger, Christian; Klein, Florian
    Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer
    In: Immunity Vol. 56 (2023) Nr. 11, pp. 2602 - 2620.e10
    Online Full Text: dx.doi.org/
  • Littwitz-Salomon, Elisabeth; Moreira, Diana; Frost, Joe N.; Choi, Chloe; Liou, Kevin T.; Ahern, David K.; O’Shaughnessy, Simon; Wagner, Bernd; Biron, Christine A.; Drakesmith, Hal; Dittmer, Ulf; Finlay, David K.
    Metabolic requirements of NK cells during the acute response against retroviral infection
    In: Nature Communications Vol. 12 (2021) Nr. 1, 5376
    Online Full Text: dx.doi.org/ (Open Access)
  • Heming, Michael; Li, Xiaolin; Räuber, Saskia; Mausberg, Anne K.; Börsch, Anna-Lena; Hartlehnert, Maike; Singhal, Arpita; Lu, I-Na; Fleischer, Michael; Szepanowski, Fabian; Witzke, Oliver; Brenner, Thorsten; Dittmer, Ulf; Yosef, Nir; Kleinschnitz, Christoph; Wiendl, Heinz; Stettner, Mark; Meyer zu Hörste, Gerd
    Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid
    In: Immunity Vol. 54 (2021) Nr. 1, pp. 164
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Wu, Jun; Liang, Boyun; Chen, Cunrong; Wang, Hua; Fang, Yaohui; Shen, Shu; Yang, Xiaoli; Wang, Baoju; Chen, Liangkai; Chen, Qi; Wu, Yang; Liu, Jia; Yang, Xuecheng; Li, Wei; Zhu, Bin; Zhou, Wenqing; Wang, Huan; Li, Sumeng; Lu, Sihong; Liu, Di; Li, Huadong; Krawczyk, Adalbert; Lu, Mengji; Yang, Dongliang; Deng, Fei; Dittmer, Ulf; Trilling, Mirko; Zheng, Xin
    SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1813
    Online Full Text: dx.doi.org/ (Open Access)
  • Bazinet, Michel; Pântea, Victor; Placinta, Gheorghe; Moscalu, Iurie; Cebotarescu, Valentin; Cojuhari, Lilia; Jimbei, Pavlina; Iarovoi, Liviu; Smesnoi, Valentina; Musteata, Tatiana; Jucov, Alina; Dittmer, Ulf; Krawczyk, Adalbert; Vaillant, Andrew
    Safety and Efficacy of 48 Weeks REP 2139 or REP 2165, Tenofovir Disoproxil, and Pegylated Interferon Alfa-2a in Patients With Chronic HBV Infection Naïve to Nucleos(t)ide Therapy
    In: Gastroenterology Vol. 158 (2020) Nr. 8, pp. 2180 - 2194
    Online Full Text: dx.doi.org/ (Open Access)
  • Stepanova, Tatyana; Haefeli, Walter-Emil; Dittmer, Ulf; Ciesek, Sandra; Bremer, Birgit; Dandri, Maura; Burhenne, Jürgen; Voronkova, Natalia; Wedemeyer, Heiner; Alexandrov, Alexander; Urban, Stephan; Allweiss, Lena; Bogomolov, Pavel O.; Schöneweis, Katrin; Chulanov, Vladimir
    Final results of a multicenter, open-label phase 2 clinical trial (MYR203) to assess safety and efficacy of myrcludex B in cwith PEG-interferon Alpha 2a in patients with chronic HBV/HDV co-infection
    In: Journal of Hepatology Vol. 70 (2019) Nr. 1 Suppl., pp. e81
    Online Full Text: dx.doi.org/
  • Yang, Shangqing; Wang, Lu; Pan, Wen; Bayer, Wibke; Thoens, Christine; Heim, Kathrin; Dittmer, Ulf; Timm, Jörg; Wang, Qin; Yu, Qing; Luo, Jinzhuo; Liu, Yanan; Hofmann, Maike; Thimme, Robert; Zhang, Xiaoyong; Chen, Hongtao; Wang, Hua; Feng, Xuemei; Yang, Xuecheng; Lu, Yinping; Lu, Mengji; Yang, Dongliang; Liu, Jia
    MMP2/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearance
    In: Journal of Hepatology Vol. 71 (2019) Nr. 4, pp. 685 - 698
    Online Full Text: dx.doi.org/
  • Khairnar, Vishal; Duhan, Vikas; Patil, Ashwini M.; Zhou, Fan; Bhat, Hilal; Thoens, Christine; Sharma, Piyush; Adomati, Tom; Friendrich, Sarah-Kim; Bezgovsek, Judith; Dreesen, Janine D.; Wennemuth, Gunther; Westendorf, Astrid; Zelinskyy, Gennadiy; Dittmer, Ulf; Hardt, Cornelia; Timm, Jörg; Göthert, Joachim Rudolf; Lang, Philipp A.; Singer, Bernhard B.; Lang, Karl S.
    CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infection
    In: Nature Communications Vol. 9 (2018) 2561
    Online Full Text: dx.doi.org/ (Open Access)
  • Klein, Johanna C.; Moses, Katrin; Zelinskyy, Gennadiy; Sody, Simon; Buer, Jan; Lang, Stephan; Helfrich, Iris; Dittmer, Ulf; Kirschning, Carsten Jürgen; Brandau, Sven
    Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth
    In: Nature Communications Vol. 8 (2017) pp. 14600
    Online Full Text: dx.doi.org/ (Open Access)
  • Schultz, Bruce T.; Teigler, Jeffrey E.; Pissani, Franco; Oster, Alexander F.; Kranias, Gregory; Alter, Galit; Marovich, Mary; Eller, Michael A.; Dittmer, Ulf; Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.; Bolton, Diane; Streeck, Hendrik
    Circulating HIV-Specific Interleukin-21
    In: Immunity Vol. 44 (2016) Nr. 1, pp. 167 - 178
    Online Full Text: dx.doi.org/ (Open Access)
  • Kordelas, Lambros; Verheyen, Jens; Beelen, Dietrich; Horn, Peter; Heinold, Andreas; Kaiser, Rolf; Trenschel, Rudolf; Schadendorf, Dirk; Dittmer, Ulf; Esser, Stefan
    Shift of HIV tropism in stem-cell transplantation with CCR5 Delta32 mutation
    In: The New England Journal of Medicine Vol. 371 (2014) Nr. 9, pp. 880 - 882
    Online Full Text: dx.doi.org/
  • Lavender, Kerry J.; Pang, Wendy W.; Messer, Ronald J.; Duley, Amanda K.; Race, Brent; Phillips, Katie; Scott, Dana; Peterson, Karin E.; Chan, Charles K.; Dittmer, Ulf; Dudek, Timothy; Allen, Todd M.; Weissman, Irving L.; Hasenkrug, Kim J.
    BLT-humanized C57BL/6 Rag2⁻/⁻γc⁻/⁻CD47⁻/⁻ mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection
    In: Blood Vol. 122 (2013) Nr. 25, pp. 4013 - 4020
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Drosten, Christian; Seilmaier, Michael; Corman, Victor M; Hartmann, Wulf; Scheible, Gregor; Sack, Stefan; Guggemos, Wolfgang; Kallies, Rene; Muth, Doreen; Junglen, Sandra; Müller, Marcel A; Haas, Walter; Guberina, Hana; Röhnisch, Tim; Schmid-Wendtner, Monika; Aldabbagh, Souhaib; Dittmer, Ulf; Gold, Hermann; Graf, Petra; Bonin, Frank; Rambaut, Andrew; Wendtner, Clemens-Martin
    Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection
    In: The Lancet Infectious Diseases Vol. 13 (2013) Nr. 9, pp. 745 - 751
    Online Full Text: dx.doi.org/
  • Balkow, Sandra; Krux, Frank; Loser, Karin; Becker, Jan U.; Grabbe, Stephan; Dittmer, Ulf
    Friend retrovirus infection of myeloid dendritic cells impairs maturation, prolongs contact to naïve T cells, and favors expansion of regulatory T cells
    In: Blood Vol. 110 (2007) Nr. 12, pp. 3949 - 3958
    Online Full Text: dx.doi.org/ (Open Access)
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