ZMB Member Elke Cario

ZMB Member
Elke Cario

Next ZMB-Member
portrait picture Elke Cario
© Elke Cario

Prof. Dr. Elke Cario

Clinic for Gastroenterology and Hepatology
University Hospital Essen
Hufelandstr. 55
45147 Essen

Research Overview

  1. Elucidation of innate immune checkpoints to maintain gut homeostasis
  2. Role and regulation of the intestinal epithelium in health and disease
  3. Regulatory mechanisms of xenobiotic-host metabolism mediated by gut microbiota and their consequences for cancer therapy
© Elke Cario
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    Journal articles

  • David, Paul; Drabczyk-Pluta, Malgorzata; Pastille, Eva; Knuschke, Torben; Werner, Tanja; Honke, Nadine; Megger, Dominik A.; Akhmetzyanova, Ilseyar; Shaabani, Namir; Eyking-Singer, Annette; Cario, Elke; Kershaw, Olivia; Gruber, Achim D.; Tenbusch, Matthias; Dietze, Kirsten; Trilling, Mirko; Liu, Jia; Schadendorf, Dirk; Streeck, Hendrik; Lang, Karl S.; Xie, Youhua; Zimmer, Lisa; Sitek, Barbara; Paschen, Annette; Westendorf, Astrid; Dittmer, Ulf; Zelinskyy, Gennadiy
    Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology
    In: PLoS Pathogens Vol. 16 (2020) Nr. 3, e1008340
  • Eyking, Annette; Ferber, Frederike; Köhler, Stefanie; Reis, Henning; Cario, Elke
    TRIM58 Restrains Intestinal Mucosal Inflammation by Negatively Regulating TLR2 in Myeloid Cells
    In: The Journal of Immunology (JI) Vol. 203 (2019) Nr. 6, pp. 1636 - 1649
  • Hennenberg, Eva Maria; Eyking, Annette; Reis, Henning; Cario, Elke
    MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis
    In: PLoS ONE Vol. 12 (2017) Nr. 7, pp. e0180834
  • Cario, Elke
    P-glycoprotein multidrug transporter in inflammatory bowel diseases : More questions than answers
    In: World Journal of Gastroenterology Vol. 23 (2017) Nr. 9, pp. 1513 - 1520
  • Gedik, Nilgün; Krüger, Marcus; Thielmann, Matthias Klaus; Kottenberg, Eva; Skyschally, Andreas; Frey, Ulrich; Cario, Elke; Peters, Jürgen; Jakob, Heinz G.; Heusch, Gerd; Kleinbongard, Petra
    Proteomics/phosphoproteomics of left ventricular biopsies from patients with surgical coronary revascularization and pigs with coronary occlusion/reperfusion : Remote ischemic preconditioning
    In: Scientific Reports Vol. 7 (2017) Nr. 1,
  • Kraiczy, J.; Zilbauer, M.; Heuschkel, R; Cario, Elke; Gasparetto, M.; Mak, T N; Raine, T.; Nayak, K.; Rakyan, V.
    Assessing DNA methylation in the developing human intestinal epithelium : potential link to inflammatory bowel disease
    In: Mucosal Immunology Vol. 9 (2016) Nr. 3, pp. 647 - 658
  • Fielitz, Kathrin; Althoff, Kristina; De Preter, Katleen; Nonnekens, Julie; Ohli, Jasmin; Elges, Sandra; Hartmann, Wolfgang; Klöppel, Günter; Knösel, Thomas; Schulte, Marc; Klein-Hitpaß, Ludger; Beisser, Daniela; Reis, Henning; Eyking, Annette; Cario, Elke; Schulte, Johannes; Schramm, Alexander; Schüller, Ulrich
    Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells
    In: OncoTarget Vol. 7 (2016) Nr. 46, pp. 74415 - 74426
  • Eyking, Annette; Reis, Henning; Frank, Magdalena; Gerken, Guido; Schmid, Kurt Werner; Cario, Elke
    MiR-205 and MiR-373 Are Associated with Aggressive Human Mucinous Colorectal Cancer
    In: PLoS ONE Vol. 11 (2016) Nr. 6, pp. e0156871
  • Cario, Elke
    Toll-like receptors in the pathogenesis of chemotherapy-induced gastrointestinal toxicity
    In: Current Opinion in Supportive and Palliative Care Vol. 10 (2016) Nr. 2, pp. 157 - 164
  • Frank, Magdalena; Hennenberg, Eva Maria; Eyking, Annette; Rünzi, Michael; Gerken, Guido; Scott, Paul; Parkhill, Julian; Walker, Alan W; Cario, Elke
    TLR Signaling Modulates Side Effects of Anticancer Therapy in the Small Intestine
    In: The Journal of Immunology (JI) Vol. 194 (2015) Nr. 4, pp. 1983 - 1995
  • Baars, Theodor; Skyschally, Andreas; Klein-Hitpaß, Ludger; Cario, Elke; Erbel, Raimund; Heusch, Gerd; Kleinbongard, Petra
    microRNA expression and its potential role in cardioprotection by ischemic postconditioning in pigs
    In: Pflügers Archiv: European Journal of Physiology Vol. 466 (2014) Nr. 10, pp. 1953 - 1961
  • Ey, Birgit; Eyking, Annette; Klepak, Magdalena; Salzman, Nita H.; Göthert, Joachim Rudolf; Rünzi, Michael; Schmid, Kurt Werner; Gerken, Guido; Podolsky, Daniel K.; Cario, Elke
    Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis
    In: The Journal of Immunology (JI) Vol. 190 (2013) Nr. 11, pp. 5676 - 5688
  • Cario, Elke
    Microbiota and innate immunity in intestinal inflammation and neoplasia
    In: Current Opinion in Gastroenterology Vol. 29 (2013) Nr. 1, pp. 85 - 91
  • Cario, Elke
    The human TLR4 variant D299G mediates inflammation-associated cancer progression in the intestinal epithelium
    In: OncoImmunology Vol. 2 (2013) Nr. 7, e24890
  • Cario, Elke
    Commensal-Innate Immune Miscommunication in IBD Pathogenesis
    In: Digestive Diseases Vol. 30 (2012) Nr. 4, pp. 334 - 340
  • Cario, Elke
    Nanotechnology-based drug delivery in mucosal immune diseases : hype or hope?
    In: Mucosal Immunology Vol. 5 (2012) Nr. 1, pp. 2 - 3
  • Ey, Birgit; Gerken, Guido; Podolsky, Daniel K.; Cario, Elke
    IL-IR/MyD88 Signalling Mediates Severity of UC-Like Pancolitis in TLR2/MDRIA Double Deficient Mice
    In: Gastroenterology Vol. 140 (2011) Nr. 5 Suppl. 1, pp. S143 - S144
  • Klocke, Julia; Barcia, Rita N.; Heimer, Susan; Cario, Elke; Zieske, James; Gilmore, Michael S.; Ksander, Bruce R.; Gregory, Meredith S.
    Spontaneous bacterial keratitis in CD36 knockout mice
    In: Investigative Ophthalmology & Visual Science, IOVS Vol. 52 (2011) Nr. 1, pp. 256 - 263
  • Eyking, Annette; Ey, Birgit; Rünzi, Michael; Roig, Andres I.; Reis, Henning; Gerken, Guido; Schmid, Kurt Werner; Podolsky, Daniel K.; Cario, Elke
    The Toll-like receptor (TLR) 4 variant D299G promotes inflammation-associated colon cancer progression in the intestinal epithelium
    In: Inflammatory Bowel Diseases Vol. 17 (2011) Nr. Suppl. 2, pp. S84
  • Eyking, Annette; Ey, Birgit; Rünzi, Michael; Roig, Andres I.; Reis, Henning; Schmid, Kurt Werner; Gerken, Guido; Podolsky, Daniel K.; Cario, Elke
    Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer
    In: Gastroenterology Vol. 141 (2011) Nr. 6, pp. 2154 - 2165
  • Cario, Elke
    Heads up! How the intestinal epithelium safeguards mucosal barrier immunity through the inflammasome and beyond
    In: Current Opinion in Gastroenterology Vol. 26 (2010) Nr. 6, pp. 583 - 590
  • Cario, Elke
    Toll-like receptors in inflammatory bowel diseases: A decade later
    In: Inflammatory Bowel Diseases Vol. 16 (2010) Nr. 9, pp. 1583 - 1597