ZMB Member Cläre von Neubeck

ZMB Member
Cläre von Neubeck

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Cläre von Neubeck portrait

Prof. Dr. Cläre von Neubeck

Clinic for Particle Therapy
University Hospital Essen
Hufelandstraße 55
45122 Essen

Research Overview

  • Particle radiation (investigating the relative biological effectiveness (RBE) in mono/ co-cultures, organotypic models, organ slice cultures and animal models)
  • Experimental radiotherapy (investigating in established and primary tumor models in vivo/ ex vivo, biomarkers for radiosensitivity, tumor micromilieu, and combined radio-oncological therapy modalities)

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Selected Publications

    Journal articles

  • Suckert, Theresa; Müller, Johannes; Beyreuther, Elke; Azadegan, Behnam; Brüggemann, Anja; Bütof, Rebecca; Dietrich, Antje; Gotz, Malte; Haase, Robert; Schürer, Michael; Tillner, Falk; von Neubeck, Cläre; Krause, Mechthild; Lühr, Armin
    High-precision image-guided proton irradiation of mouse brain sub-volumes
    In: Radiotherapy and Oncology Vol. 146 (2020) pp. 205 - 212
    ISSN: 1879-0887; 0167-8140
  • Rassamegevanon, Treewut; Löck, Steffen; Baumann, Michael; Krause, Mechthild; von Neubeck, Cläre
    Comparable radiation response of ex vivo and in vivo irradiated tumor samples determined by residual γH2AX
    In: Radiotherapy and Oncology Vol. 139 (2019) pp. 94 - 100
    ISSN: 0167-8140
  • Seidlitz, Therese; Merker, Sebastian R.; Rothe, Alexander; Zakrzewski, Falk; von Neubeck, Cläre; Grützmann, Konrad; Sommer, Ulrich; Schweitzer, Christine; Schölch, Sebastian; Uhlemann, Heike; Gaebler, Anne-Marlene; Werner, Kristin; Krause, Mechthild; Baretton, Gustavo B.; Welsch, Thilo; Koo, Bon-Kyoung; Aust, Daniela E.; Klink, Barbara; Weitz, Jürgen; Stange, Daniel E.
    Human gastric cancer modelling using organoids
    In: Gut Vol. 68 (2019) Nr. 2, pp. 207 - 217
    ISSN: 1468-3288; 0017-5749
  • Meneceur, Sarah; Löck, Steffen; Gudziol, Volker; Hering, Sandra; Bütof, Rebecca; Rehm, Maximilian; Baumann, Michael; Krause, Mechthild; von Neubeck, Cläre
    Residual gammaH2AX foci in head and neck squamous cell carcinomas as predictors for tumour radiosensitivity : Evaluation in pre-clinical xenograft models and clinical specimens
    In: Radiotherapy and Oncology Vol. 137 (2019) pp. 24 - 31
    ISSN: 0167-8140
  • Linge, Annett; Schötz, Ulrike; Löck, Steffen; Lohaus, Fabian; von Neubeck, Cläre; Gudziol, Volker; Nowak, Alexander; Tinhofer, Inge; Budach, Volker; Sak, Ali; Stuschke, Martin; Balermpas, Panagiotis; Rödel, Claus; Bunea, Hatice; Grosu, Anca-Ligia; Abdollahi, Amir; Debus, Jürgen; Ganswindt, Ute; Lauber, Kirsten; Pigorsch, Steffi; Combs, Stephanie E.; Mönnich, David; Zips, Daniel; Baretton, Gustavo B.; Buchholz, Frank; Krause, Mechthild; Belka, Claus; Baumann, Michael
    Comparison of detection methods for HPV status as a prognostic marker for loco-regional control after radiochemotherapy in patients with HNSCC
    In: Radiotherapy and Oncology Vol. 127 (2018) Nr. 1, pp. 27 - 35
    ISSN: 1879-0887; 0167-8140
  • Schmidt, Stefan; Linge, Annett; Zwanenburg, Alex; Leger, Stefan; Lohaus, Fabian; Krenn, Constanze; Appold, Steffen; Gudziol, Volker; Nowak, Alexander; von Neubeck, Cläre; Tinhofer, Inge; Budach, Volker; Sak, Ali; Stuschke, Martin; Balermpas, Panagiotis; Rodel, Claus; Bunea, Hatice; Grosu, Anca-Ligia; Abdollahi, Amir; Debus, Jurgen; Ganswindt, Ute; Belka, Claus; Pigorsch, Steffi; Combs, Stephanie E.; Monnich, David; Zips, Daniel; Baretton, Gustavo B.; Buchholz, Frank; Baumann, Michael; Krause, Mechthild; Lock, Steffen
    Development and Validation of a Gene Signature for Patients with Head and Neck Carcinomas Treated by Postoperative Radio(chemo)therapy
    In: Clinical Cancer Research Vol. 24 (2018) Nr. 6, pp. 1364 - 1374
    ISSN: 1557-3265; 1078-0432
  • Willers, Henning; Allen, Antino; Grosshans, David; McMahon, Stephen J.; von Neubeck, Cläre; Wiese, Claudia; Vikram, Bhadrasain
    Toward A variable RBE for proton beam therapy
    In: Radiotherapy and Oncology Vol. 128 (2018) Nr. 1, pp. 68 - 75
    ISSN: 0167-8140
  • Lühr, Armin; von Neubeck, Cläre; Pawelke, Jörg; Seidlitz, Annekatrin; Peitzsch, Claudia; Bentzen, Søren M.; Bortfeld, Thomas; Debus, Jürgen; Deutsch, Eric; Langendijk, Johannes A.; Loeffler, Jay S.; Mohan, Radhe; Scholz, Michael; Sørensen, Brita S.; Weber, Damien C.; Baumann, Michael; Krause, Mechthild
    “Radiobiology of Proton Therapy” : Results of an international expert workshop
    In: Radiotherapy and Oncology Vol. 128 (2018) Nr. 1, pp. 56 - 67
    ISSN: 0167-8140
  • Lühr, Armin; von Neubeck, Cläre; Helmbrecht, Stephan; Baumann, Michael; Enghardt, Wolfgang; Krause, Mechthild
    Modeling in vivo relative biological effectiveness in particle therapy for clinically relevant endpoints
    In: Acta Oncologica Vol. 56 (2017) Nr. 11, pp. 1392 - 1398
    ISSN: 0284-186X
  • Müller, Johannes; Neubert, Christian; von Neubeck, Cläre; Baumann, Michael; Krause, Mechthild; Enghardt, Wolfgang; Bütof, Rebecca; Dietrich, Antje; Lühr, Armin
    Proton radiography for inline treatment planning and positioning verification of small animals
    In: Acta Oncologica Vol. 56 (2017) Nr. 11, pp. 1399 - 1405
    ISSN: 0284-186X
  • Rassamegevanon, Treewut; Löck, Steffen; Range, Ursula; Krause, Mechthild; Baumann, Michael; von Neubeck, Cläre
    Tumor heterogeneity determined with a γH2AX foci assay : A study in human head and neck squamous cell carcinoma (hHNSCC) models
    In: Radiotherapy and Oncology Vol. 124 (2017) Nr. 3, pp. 379 - 385
    ISSN: 0167-8140
  • Linge, Annett; Lohaus, Fabian; Löck, Steffen; Nowak, Alexander; Gudziol, Volker; Valentini, Chiara; von Neubeck, Cläre; Jütz, Martin; Tinhofer, Inge; Budach, Volker; Sak, Ali; Stuschke, Martin; Balermpas, Panagiotis; Rödel, Claus; Grosu, Anca-Ligia; Abdollahi, Amir; Debus, Jürgen; Ganswindt, Ute; Belka, Claus; Pigorsch, Steffi; Combs, Stephanie E; Mönnich, David; Zips, Daniel; Buchholz, Frank; Aust, Daniela E; Baretton, Gustavo B; Thames, Howard D; Dubrovska, Anna; Alsner, Jan; Overgaard, Jens; Krause, Mechthild; Baumann, Michael
    HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy : A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)
    In: Radiotherapy and Oncology Vol. 121 (2016) Nr. 3, pp. 364 - 373
    ISSN: 0167-8140
  • Linge, Annett; Löck, Steffen; Gudziol, Volker; Nowak, Alexander; Lohaus, Fabian; von Neubeck, Cläre; Jütz, Martin; Abdollahi, Amir; Debus, Jürgen; Tinhofer, Inge; Budach, Volker; Sak, Ali; Stuschke, Martin; Balermpas, Panagiotis; Rödel, Claus; Avlar, Melanie; Grosu, Anca-Ligia; Bayer, Christine; Belka, Claus; Pigorsch, Steffi; Combs, Stephanie E; Welz, Stefan; Zips, Daniel; Buchholz, Frank; Aust, Daniela E; Baretton, Gustavo B; Thames, Howard D; Dubrovska, Anna; Alsner, Jan; Overgaard, Jens; Baumann, Michael; Krause, Mechthild
    Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(-) HNSCC after Postoperative Radiochemotherapy : A Multicenter Study of the DKTK-ROG
    In: Clinical Cancer Research Vol. 22 (2016) Nr. 11, pp. 2639 - 2649
    ISSN: 1078-0432
  • Lohaus, Fabian; Linge, Annett; Tinhofer, Inge; Budach, Volker; Gkika, Eleni; Stuschke, Martin; Balermpas, Panagiotis; Rödel, Claus; Avlar, Melanie; Grosu, Anca-Ligia; Abdollahi, Amir; Debus, Jürgen; Bayer, Christine; Belka, Claus; Pigorsch, Steffi; Combs, Stephanie E.; Mönnich, David; Zips, Daniel; von Neubeck, Cläre; Baretton, Gustavo B.; Löck, Steffen; Thames, Howard D.; Krause, Mechthild; Baumann, Michael
    Corrigendum to “HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: Results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)” [Radiother. Oncol. 113 (2014) 317–323]
    In: Radiotherapy and Oncology Vol. 114 (2015) Nr. 3, pp. 419
    ISSN: 0167-8140
  • Menegakis, Apostolos; von Neubeck, Cläre; Yaromina, Ala; Thames, Howard; Hering, Sandra; Hennenlotter, Joerg; Scharpf, Marcus; Noell, Susan; Krause, Mechthild; Zips, Daniel; Baumann, Michael
    γh2AX assay in ex vivo irradiated tumour specimens : A novel method to determine tumour radiation sensitivity in patient-derived material
    In: Radiotherapy and Oncology Vol. 116 (2015) Nr. 3, pp. 473 - 479
    ISSN: 0167-8140
  • Lohaus, Fabian; Linge, Annett; Tinhofer, Inge; Budach, Volker; Gkika, Eleni; Stuschke, Martin; Balermpas, Panagiotis; Rödel, Claus; Avlar, Melanie; Grosu, Anca-Ligia; Abdollahi, Amir; Debus, Jürgen; Bayer, Christine; Belka, Claus; Pigorsch, Steffi; Combs, Stephanie E; Mönnich, David; Zips, Daniel; von Neubeck, Cläre; Baretton, Gustavo B; Löck, Steffen; Thames, Howard D; Krause, Mechthild; Baumann, Michael; DKTK-ROG
    HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma : Results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)
    In: Radiotherapy and Oncology Vol. 113 (2014) Nr. 3, pp. 317 - 323
    ISSN: 0167-8140
  • Koch, Ulrike; Höhne, Katharina; von Neubeck, Cläre; Thames, Howard D.; Yaromina, Ala; Dahm-Daphi, Jochen; Baumann, Michael; Krause, Mechthild
    Residual γh2AX foci predict local tumour control after radiotherapy
    In: Radiotherapy and Oncology Vol. 108 (2013) Nr. 3, pp. 434 - 439
    ISSN: 0167-8140; 1879-0887