ZMB Member Dirk M. Hermann

ZMB Member
Dirk M. Hermann

Next ZMB-Member
Dirk M. Hermann portrait
© UKE/Hermann

Prof. Dr. Dirk M. Hermann

Group

Vascular Neurology, Dementia and Age Research

Clinic for Neurology
University Hospital Essen
Hufelandstr. 55
45122 Essen

Research Overview

  • ATP-binding cassette transporters in the ischemic brain
  • Diseases of the peripheral nervous system
  • Clinical and Experimental Neuroimmunology
  • Mechanisms of neuronal plasticity
  • Neuron-glia interactions and extracellular matrix post-stroke
  • Restorative therapies
  • Acid sphingomyelinase/ceramide system in neurovascular remodeling
  • Secondary neurodegeneration after strategic brain infarcts with cognitive deficits
  • Thromboinflammation
  • Vascular risk factors, subclinical atherosclerosis and stroke risk

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Selected Publications

    Journal articles

  • Richter, Mathis; Diesterbeck, Eva; Pylaeva, Ekaterina; Labusek, Nicole; Köster, Christian; Nagel, Dennis; Karsch, Laura; Fischer, Alexa Josephine; Sous, Marah; Jung, Marcel; Chevre, Raphael; Hagemann, Nina; Andersson, Erik Axel; Ek, C. Joakim; Singh, Vikramjeet; Hermann, Dirk M.; Gunzer, Matthias; Jablonska, Jadwiga; Felderhoff-Müser, Ursula; Bendix, Ivo; Soehnlein, Oliver; Herz, Josephine
    Hypoxic-ischemic brain injury in neonatal mice sequentially recruits neutrophils with dichotomous phenotype and function
    In: Nature Communications, Vol. 16, 2025, Nr. 1, 9696
    DOI (Open Access)
  • Hermann, Dirk M.; Peruzzotti-Jametti, Luca; Giebel, Bernd; Pluchino, Stefano
    Extracellular vesicles set the stage for brain plasticity and recovery by multimodal signalling
    In: Brain: A Journal of Neurology, Vol. 147, 2024, Nr. 2, pp. 372 – 389
    DOI (Open Access)
  • Rohlfing, Anne-Katrin; Kolb, Kyra; Sigle, Manuel; Ziegler, Melanie; Bild, Alexander; Münzer, Patrick; Sudmann, Jessica; Dicenta, Valerie; Harm, Tobias; Manke, Mailin-Christin; Geue, Sascha; Kremser, Marcel; Chatterjee, Madhumita; Liang, Chunguang; von Eysmondt, Hendrik; Dandekar, Thomas; Heinzmann, David; Günter, Manina; von Ungern-Sternberg, Saskia; Büttcher, Manuela; Castor, Tatsiana; Mencl, Stine; Langhauser, Friederike; Sies, Katharina; Ashour, Diyaa; Beker, Mustafa Caglar; Lämmerhofer, Michael; Autenrieth, Stella E.; Schäffer, Tilman E.; Laufer, Stefan; Szklanna, Paulina; Maguire, Patricia; Heikenwalder, Matthias; Müller, Karin Anne Lydia; Hermann, Dirk M.; Kilic, Ertugrul; Stumm, Ralf; Ramos, Gustavo; Kleinschnitz, Christoph; Borst, Oliver; Langer, Harald F.; Rath, Dominik; Gawaz, Meinrad
    ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury
    In: Nature Communications, Vol. 13, 2022, Nr. 1, 1823
    DOI (Open Access)
  • Beuker, Carolin; Schafflick, David; Strecker, Jan-Kolja; Heming, Michael; Li, Xiaolin; Wolbert, Jolien; Schmidt-Pogoda, Antje; Thomas, Christian; Kuhlmann, Tanja; Aranda-Pardos, Irene; A-Gonzalez, Noelia; Kumar, Praveen Ashok; Werner, Yves; Kilic, Ertugrul; Hermann, Dirk M.; Wiendl, Heinz; Stumm, Ralf; Hörste, Gerd Meyer Zu; Minnerup, Jens
    Stroke induces disease-specific myeloid cells in the brain parenchyma and pia
    In: Nature Communications, Vol. 13, 2022, Nr. 1, 945
    DOI (Open Access)
  • Hermann, Dirk M.; Bassetti, Claudio L.; Marx, Ute; Audoli-Inthavong, Marie-Laure; Chabriat, Hugues
    Refining endpoints for stroke recovery trials
    In: The Lancet Neurology, Vol. 19, 2020, Nr. 5, pp. 381 – 382
    DOI
  • Chabriat, Hugues; Bassetti, Claudio L; Marx, Ute; Audoli-Inthavong, Marie-Laure; Sors, Aurore; Lambert, Estelle; Wattez, Marine; Hermann, Dirk M.; Diener, Hans Christoph; Restore Brain Study Investigators
    Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke : A multicentre, double-blind, randomised, placebo-controlled trial
    In: The Lancet Neurology, Vol. 19, 2020, Nr. 3, pp. 226 – 233
    DOI, Online Full Text (Open Access)
  • Sokolova, Viktoriya; Nzou, Goodwell; van der Meer, Selina; Ruks, Tatjana; Heggen, Marc; Loza, Kateryna; Hagemann, Nina; Murke, Florian; Giebel, Bernd; Hermann, Dirk M.; Atala, Anthony J.; Epple, Matthias
    Ultrasmall gold nanoparticles (2 nm) can penetrate and enter cell nuclei in an in vitro 3D brain spheroid model
    In: Acta Biomaterialia, Vol. 111, 2020, pp. 349 – 362
    DOI
  • Merz, Simon F.; Korste, Sebastian; Bornemann, Lea; Michel, Lars; Stock, Pia; Squire, Anthony; Soun, Camille; Engel, Daniel Robert; Detzer, Julia; Lörchner, Holger; Hermann, Dirk M.; Kamler, Markus; Klode, Joachim; Hendgen-Cotta, Ulrike B.; Rassaf, Tienush; Gunzer, Matthias; Totzeck, Matthias
    Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response
    In: Nature Communications, Vol. 10, 2019, Nr. 1, pp. 2312
    DOI (Open Access)
  • Merz, Simon F.; Korste, Sebastian; Bornemann, Lea; Michel, Lars; Stock, Pia; Squire, Anthony; Soun, Camille; Engel, Daniel Robert; Detzer, Julia; Lörchner, Holger; Hermann, Dirk M.; Kamler, Markus; Klode, Joachim; Hendgen-Cotta, Ulrike B.; Rassaf, Tienush; Gunzer, Matthias; Totzeck, Matthias
    Publisher Correction: Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response
    In: Nature Communications, Vol. 10, 2019, Nr. 1, pp. 2768
    DOI (Open Access)
  • Minnerup, Jens; Strecker, Jan-Kolja; Wachsmuth, Lydia; Hoppen, Maike; Schmidt, Antje; Hermann, Dirk M.; Wiendl, Heinz; Meuth, Sven; Faber, Cornelius; Diederich, Kai; Schäbitz, Wolf-Rüdiger
    Defining mechanisms of neural plasticity after brainstem ischemia in rats
    In: Annals of Neurology, Vol. 83, 2018, Nr. 5, pp. 1003 – 1015
    DOI
  • Jin, Fengyan; Hagemann, Nina; Sun, Li; Wu, Jiang; Döppner, Thorsten R.; Dai, Yun; Hermann, Dirk M.
    High-density lipoprotein (HDL) promotes angiogenesis via S1P3-dependent VEGFR2 activation
    In: Angiogenesis, Vol. 21, 2018, Nr. 2, pp. 381 – 394
    DOI
  • Hermann, Dirk M.; Bassetti, Claudio L
    Author Response : Role Of Sleep-Disordered Breathing And Sleep-Wake Disturbances For Stroke And Stroke Recovery
    In: Neurology, Vol. 88, 2017, Nr. 2, pp. 220 – 221
    DOI
  • Hermann, Dirk M.; Bassetti, Claudio L
    Role of sleep-disordered breathing and sleep-wake disturbances for stroke and stroke recovery
    In: Neurology, Vol. 87, 2016, Nr. 13, pp. 1407 – 1416
    DOI (Open Access)
  • Zang, Meirong; Li, Zengjun; Liu, Lanting; Li, Fei; Li, Xin; Dai, Yun; Li, Wei; Kuckelkorn, Ulrike; Döppner, Thorsten R.; Hermann, Dirk M.; Zhou, Wen; Qiu, Lugui; Jin, Fengyan
    Anti-tumor activity of the proteasome inhibitor BSc2118 against human multiple myeloma
    In: Cancer Letters, Vol. 366, 2015, Nr. 2, pp. 173 – 181
    DOI
  • Reitmeir, Raluca; Kilic, Ertugrul; Reinboth, Barbara S.; Guo, Zeyun; ElAli, Ayman; Zechariah, Anil; Kilic, Ülkan; Hermann, Dirk
    Erratum to : Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain
    In: Acta Neuropathologica, Vol. 130, 2015, Nr. 4, pp. 603
    DOI
  • Neumann, Jens; Riek-Burchardt, Monika; Herz, Josephine; Döppner, Thorsten R.; König, Rebecca; Hütten, Heiko; Etemire, Eloho; Männ, Linda; Klingberg, Anika; Fischer, Thomas; Görtler, Michael W; Heinze, Hans-Jochen; Reichardt, Peter; Schraven, Burkhart; Hermann, Dirk M.; Reymann, Klaus G; Gunzer, Matthias
    Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke
    In: Acta Neuropathologica, Vol. 129, 2015, Nr. 2, pp. 259 – 277
    DOI
  • Jin, Fengyan; Hagemann, Nina; Brockmeier, Ulf; Schäfer, Simon T.; Zechariah, Anil; Hermann, Dirk M.
    LDL attenuates VEGF-induced angiogenesis via mechanisms involving VEGFR2 internalization and degradation following endosome-trans-Golgi network trafficking
    In: Angiogenesis, Vol. 16, 2013, Nr. 3, pp. 625 – 637
    DOI
  • Döppner, Thorsten R.; Doehring, Maria; Bretschneider, Eva; Zechariah, Anil; Kaltwasser, Britta; Müller, Barbara; Koch, Jan C.; Bähr, Mathias; Hermann, Dirk M.; Michel, Uwe
    MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation
    In: Acta Neuropathologica, Vol. 126, 2013, Nr. 2, pp. 251 – 265
    DOI
  • Hermann, Dirk M.; Chopp, Michael
    Promoting brain remodelling and plasticity for stroke recovery : Therapeutic promise and potential pitfalls of clinical translation
    In: The Lancet Neurology, Vol. 11, 2012, Nr. 4, pp. 369 – 380
    DOI
  • Hermann, Dirk M.; ElAli, Ayman
    The abluminal endothelial membrane in neurovascular remodeling in health and disease
    In: Science Signaling, Vol. 5, 2012, Nr. 236, pp. re4
    DOI
  • Döppner, Thorsten R.; Mlynarczuk-Bialy, Izabela; Kuckelkorn, Ulrike; Kaltwasser, Britta; Herz, Josephine; Hasan, Mohammad R.; Hermann, Dirk M.; Bähr, Mathias
    The novel proteasome inhibitor BSc2118 protects against cerebral ischaemia through HIF1A accumulation and enhanced angioneurogenesis
    In: Brain: A Journal of Neurology, Vol. 135, 2012, Nr. 11, pp. 3282 – 3297
    DOI
  • Reitmeir, Raluca; Kilic, Ertugrul; Reinboth, Barbara S.; Guo, Zeyun; Elali, Ayman; Zechariah, Anil; Kilic, Ülkan; Hermann, Dirk M.
    Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain
    In: Acta Neuropathologica, Vol. 123, 2012, Nr. 2, pp. 273 – 284
    DOI
  • Hermann, Dirk M.; Keyvani, Kathy; van de Nes, Johannes; Weimar, Christian; Wiltfang, Jens; Nitsch, Roger M.; Szodorai, Anita
    Brain-reactive  β-amyloid antibodies in primary cns angiitis with cerebral amyloid angiopathy
    In: Neurology, Vol. 77, 2011, Nr. 5, pp. 503 – 505
    DOI
  • Döppner, Thorsten R.; Bretschneider, Eva; Doehring, Maria; Segura, Inmaculada; Sentürk, Aycan; Acker-Palmer, Amparo; Hasan, Mohammad R.; Elali, Ayman; Hermann, Dirk M.; Bähr, Mathias
    Enhancement of endogenous neurogenesis in ephrin-B3 deficient mice after transient focal cerebral ischemia
    In: Acta Neuropathologica, Vol. 122, 2011, Nr. 4, pp. 429 – 442
    DOI (Open Access)
  • Reitmeir, Raluca; Kilic, Ertugrul; Kilic, Ülkan; Bacigaluppi, Marco; Elali, Ayman; Salani, Giuliana; Pluchino, Stefano; Gassmann, Max; Hermann, Dirk M.
    Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity
    In: Brain: A Journal of Neurology, Vol. 134, 2011, Nr. 1, pp. 84 – 99
    DOI
  • ElAli, Ayman; Hermann, Dirk M.
    Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain
    In: Science Signaling, Vol. 3, 2010, Nr. 142, pp. ra72
    DOI
  • Bacigaluppi, M.; Pluchino, S.; Peruzzotti-Jametti, L.; Kilic, E.; Kilic, U.; Salani, G.; Brambilla, E.; West, M. J.; Comi, G.; Martino, G.; Hermann, Dirk M.
    Erratum: Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms
    In: Brain: A Journal of Neurology, Vol. 133, 2010, Nr. 11, pp. 3483
    DOI
  • Hermann, Dirk M.; VanHook, Annalisa M.
    Science Signaling podcast: 5 October 2010 [Podcast-Beitrag]
    In: Science Signaling, Vol. 3, 2010, Nr. 142, pp. c18
    DOI
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