ZMB Member Dirk M. Hermann

ZMB Member
Dirk M. Hermann

Next ZMB-Member
Dirk M. Hermann portrait
© UKE/Hermann

Prof. Dr. Dirk M. Hermann

Clinic for Neurology
University Hospital Essen
Hufelandstr. 55
45122 Essen

Research Overview

  • ATP-binding cassette transporters in the ischemic brain
  • Diseases of the peripheral nervous system
  • Clinical and Experimental Neuroimmunology
  • Mechanisms of neuronal plasticity
  • Neuron-glia interactions and extracellular matrix post-stroke
  • Restorative therapies
  • Acid sphingomyelinase/ceramide system in neurovascular remodeling
  • Secondary neurodegeneration after strategic brain infarcts with cognitive deficits
  • Thromboinflammation
  • Vascular risk factors, subclinical atherosclerosis and stroke risk

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Selected Publications

    Journal articles

  • Hermann, Dirk M.; Bassetti, Claudio L.; Marx, Ute; Audoli-Inthavong, Marie-Laure; Chabriat, Hugues
    Refining endpoints for stroke recovery trials
    In: The Lancet Neurology Vol. 19 (2020) Nr. 5, pp. 381 - 382
    ISSN: 1474-4465; 1474-4422
  • Chabriat, Hugues; Bassetti, Claudio L; Marx, Ute; Audoli-Inthavong, Marie-Laure; Sors, Aurore; Lambert, Estelle; Wattez, Marine; Hermann, Dirk M.; Diener, Hans Christoph; Restore Brain Study Investigators
    Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke : A multicentre, double-blind, randomised, placebo-controlled trial
    In: The Lancet Neurology Vol. 19 (2020) Nr. 3, pp. 226 - 233
    ISSN: 1474-4465; 1474-4422
  • Sokolova, Viktoriya; Nzou, Goodwell; van der Meer, Selina; Ruks, Tatjana; Heggen, Marc; Loza, Kateryna; Hagemann, Nina; Murke, Florian; Giebel, Bernd; Hermann, Dirk M.; Atala, Anthony J.; Epple, Matthias
    Ultrasmall gold nanoparticles (2 nm) can penetrate and enter cell nuclei in an in vitro 3D brain spheroid model
    In: Acta Biomaterialia Vol. 111 (2020) pp. 349 - 362
    ISSN: 1878-7568; 1742-7061
  • Merz, Simon F.; Korste, Sebastian; Bornemann, Lea; Michel, Lars; Stock, Pia; Squire, Anthony; Soun, Camille; Engel, Daniel Robert; Detzer, Julia; Lörchner, Holger; Hermann, Dirk M.; Kamler, Markus; Klode, Joachim; Hendgen-Cotta, Ulrike B.; Rassaf, Tienush; Gunzer, Matthias; Totzeck, Matthias
    Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2312
    ISSN: 2041-1723
  • Merz, Simon F.; Korste, Sebastian; Bornemann, Lea; Michel, Lars; Stock, Pia; Squire, Anthony; Soun, Camille; Engel, Daniel Robert; Detzer, Julia; Lörchner, Holger; Hermann, Dirk M.; Kamler, Markus; Klode, Joachim; Hendgen-Cotta, Ulrike B.; Rassaf, Tienush; Gunzer, Matthias; Totzeck, Matthias
    Publisher Correction: Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2768
    ISSN: 2041-1723
  • Minnerup, Jens; Strecker, Jan-Kolja; Wachsmuth, Lydia; Hoppen, Maike; Schmidt, Antje; Hermann, Dirk M.; Wiendl, Heinz; Meuth, Sven; Faber, Cornelius; Diederich, Kai; Schäbitz, Wolf-Rüdiger
    Defining mechanisms of neural plasticity after brainstem ischemia in rats
    In: Annals of Neurology Vol. 83 (2018) Nr. 5, pp. 1003 - 1015
    ISSN: 1531-8249; 0364-5134
  • Jin, Fengyan; Hagemann, Nina; Sun, Li; Wu, Jiang; Döppner, Thorsten R.; Dai, Yun; Hermann, Dirk M.
    High-density lipoprotein (HDL) promotes angiogenesis via S1P3-dependent VEGFR2 activation
    In: Angiogenesis Vol. 21 (2018) Nr. 2, pp. 381 - 394
    ISSN: 1573-7209; 0969-6970
  • Hermann, Dirk M.; Bassetti, Claudio L
    Author Response : Role Of Sleep-Disordered Breathing And Sleep-Wake Disturbances For Stroke And Stroke Recovery
    In: Neurology Vol. 88 (2017) Nr. 2, pp. 220 - 221
    ISSN: 0028-3878; 1526-632X
  • Hermann, Dirk M.; Bassetti, Claudio L
    Role of sleep-disordered breathing and sleep-wake disturbances for stroke and stroke recovery
    In: Neurology Vol. 87 (2016) Nr. 13, pp. 1407 - 1416
    ISSN: 0028-3878; 1526-632X
  • Zang, Meirong; Li, Zengjun; Liu, Lanting; Li, Fei; Li, Xin; Dai, Yun; Li, Wei; Kuckelkorn, Ulrike; Döppner, Thorsten R.; Hermann, Dirk M.; Zhou, Wen; Qiu, Lugui; Jin, Fengyan
    Anti-tumor activity of the proteasome inhibitor BSc2118 against human multiple myeloma
    In: Cancer Letters Vol. 366 (2015) Nr. 2, pp. 173 - 181
    ISSN: 1872-7980; 0304-3835
  • Reitmeir, Raluca; Kilic, Ertugrul; Reinboth, Barbara S.; Guo, Zeyun; ElAli, Ayman; Zechariah, Anil; Kilic, Ülkan; Hermann, Dirk
    Erratum to : Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain
    In: Acta Neuropathologica Vol. 130 (2015) Nr. 4, pp. 603
    ISSN: 1432-0533; 0001-6322
  • Neumann, Jens; Riek-Burchardt, Monika; Herz, Josephine; Döppner, Thorsten R.; König, Rebecca; Hütten, Heiko; Etemire, Eloho; Männ, Linda; Klingberg, Anika; Fischer, Thomas; Görtler, Michael W; Heinze, Hans-Jochen; Reichardt, Peter; Schraven, Burkhart; Hermann, Dirk M.; Reymann, Klaus G; Gunzer, Matthias
    Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke
    In: Acta Neuropathologica Vol. 129 (2015) Nr. 2, pp. 259 - 277
    ISSN: 0001-6322; 1432-0533
  • Jin, Fengyan; Hagemann, Nina; Brockmeier, Ulf; Schäfer, Simon T.; Zechariah, Anil; Hermann, Dirk M.
    LDL attenuates VEGF-induced angiogenesis via mechanisms involving VEGFR2 internalization and degradation following endosome-trans-Golgi network trafficking
    In: Angiogenesis Vol. 16 (2013) Nr. 3, pp. 625 - 637
    ISSN: 0969-6970; 1573-7209
  • Hermann, Dirk M.; Chopp, Michael
    Promoting brain remodelling and plasticity for stroke recovery : Therapeutic promise and potential pitfalls of clinical translation
    In: The Lancet Neurology Vol. 11 (2012) Nr. 4, pp. 369 - 380
    ISSN: 1474-4422; 1474-4465
  • Hermann, Dirk M.; ElAli, Ayman
    The abluminal endothelial membrane in neurovascular remodeling in health and disease
    In: Science Signaling Vol. 5 (2012) Nr. 236, pp. re4
    ISSN: 1945-0877; 1937-9145
  • Döppner, Thorsten R.; Mlynarczuk-Bialy, Izabela; Kuckelkorn, Ulrike; Kaltwasser, Britta; Herz, Josephine; Hasan, Mohammad R.; Hermann, Dirk M.; Bähr, Mathias
    The novel proteasome inhibitor BSc2118 protects against cerebral ischaemia through HIF1A accumulation and enhanced angioneurogenesis
    In: Brain: A Journal of Neurology Vol. 135 (2012) Nr. 11, pp. 3282 - 3297
    ISSN: 0006-8950; 1460-2156
  • Reitmeir, Raluca; Kilic, Ertugrul; Reinboth, Barbara S.; Guo, Zeyun; Elali, Ayman; Zechariah, Anil; Kilic, Ülkan; Hermann, Dirk M.
    Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain
    In: Acta Neuropathologica Vol. 123 (2012) Nr. 2, pp. 273 - 284
    ISSN: 0001-6322; 1432-0533
  • Hermann, Dirk M.; Keyvani, Kathy; van de Nes, Johannes; Weimar, Christian; Wiltfang, Jens; Nitsch, Roger M.; Szodorai, Anita
    Brain-reactive  β-amyloid antibodies in primary cns angiitis with cerebral amyloid angiopathy
    In: Neurology Vol. 77 (2011) Nr. 5, pp. 503 - 505
    ISSN: 1526-632X; 0028-3878
  • Döppner, Thorsten R.; Bretschneider, Eva; Doehring, Maria; Segura, Inmaculada; Sentürk, Aycan; Acker-Palmer, Amparo; Hasan, Mohammad R.; Elali, Ayman; Hermann, Dirk M.; Bähr, Mathias
    Enhancement of endogenous neurogenesis in ephrin-B3 deficient mice after transient focal cerebral ischemia
    In: Acta Neuropathologica Vol. 122 (2011) Nr. 4, pp. 429 - 442
    ISSN: 1432-0533; 0001-6322
  • Reitmeir, Raluca; Kilic, Ertugrul; Kilic, Ülkan; Bacigaluppi, Marco; Elali, Ayman; Salani, Giuliana; Pluchino, Stefano; Gassmann, Max; Hermann, Dirk M.
    Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity
    In: Brain: A Journal of Neurology Vol. 134 (2011) Nr. 1, pp. 84 - 99
    ISSN: 0006-8950; 1460-2156
  • ElAli, Ayman; Hermann, Dirk M.
    Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain
    In: Science Signaling Vol. 3 (2010) Nr. 142, pp. ra72
    ISSN: 1937-9145; 1945-0877; 1937-9145
  • Bacigaluppi, M.; Pluchino, S.; Peruzzotti-Jametti, L.; Kilic, E.; Kilic, U.; Salani, G.; Brambilla, E.; West, M. J.; Comi, G.; Martino, G.; Hermann, Dirk M.
    Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. (vol 132, pg 2239, 2009)
    In: Brain: A Journal of Neurology Vol. 133 (2010) Nr. 3483-3483, pp. 3483
    ISSN: 0006-8950; 1460-2156
  • Hermann, Dirk M.; VanHook, Annalisa M.
    Science Signaling podcast: 5 October 2010 [Podcast-Beitrag]
    In: Science Signaling Vol. 3 (2010) Nr. 142, pp. c18
    ISSN: 1945-0877; 1937-9145