ZMB Member Silvia Vega-Rubín-de-Celis

ZMB Member
Silvia Vega-Rubín-de-Celis

Next ZMB-Member

© UKE/Vega-Rubín-de-Celis

Dr. Silvia Vega-Rubín-de-Celis

Junior Research Group

Autophagy in Cancer

Institute of Cell Biology (Tumor Research)
University Hospital Essen
Virchowstr. 173
45122 Essen

Research Overview

The research focus of my group revolves around understanding the role of autophagy in cancer and exploring the use of autophagy modulating agents as potential therapeutic targets in tumors. We undertake a variety of approaches, from understanding basic molecular biology mechanisms in cell lines and patient samples to ultimately translate the findings into the clinic.
Read more


    Journal articles

  • Hegedüs, Luca; Okumus, Özlem; Mairinger, Fabian; Ploenes, Till; Reuter, Sebastian; Schuler, Martin; Welt, Anja; Vega-Rubin-de-Celis, Silvia; Theegarten, Dirk; Bankfalvi, Agnes; Aigner, Clemens; Hegedüs, Balazs
    TROP2 expression and SN38 antitumor activity in malignant pleural mesothelioma cells provide a rationale for antibody-drug conjugate therapy
    In: Lung Cancer Vol. 178 (2023) pp. 237 - 246
    ISSN: 1872-8332; 0169-5002
  • Hegedüs, Luca; Szücs, Kata D.; Kudla, Matthias; Heidenreich, Julian; Jendrossek, Verena; Peña-Llopis, Samuel; Garay, Tamas; Czirok, Andras; Aigner, Clemens; Plönes, Till; Vega-Rubin-de-Celis, Silvia; Hegedüs, Balazs
    Nintedanib and Dasatinib Treatments Induce Protective Autophagy as a Potential Resistance Mechanism in MPM Cells
    In: Frontiers in Cell and Developmental Biology Vol. 10 (2022)
    ISSN: 2296-634X
  • Niersch, Jennifer; Vega-Rubín-de-Celis, Silvia; Bazarna, Anna; Mergener, Svenja; Jendrossek, Verena; Siveke, Jens; Peña-Llopis, Samuel
    A BAP1 synonymous mutation results in exon skipping, loss of function and worse patient prognosis
    In: iScience Vol. 24 (2021) Nr. 3,
    ISSN: 2589-0042
  • Mitra, Devina; Vega-Rubín-de-Celis, Silvia; Royla, Nadine; Bernhardt, Stephan; Wilhelm, Heike; Tarade, Nooraldeen; Poschet, Gernot; Buettner, Michael; Binenbaum, Ilona; Borgoni, Simone; Vetter, Martina; Kantelhardt, Eva Johanna; Thomssen, Christoph; Chatziioannou, Aristotelis; Hell, Rüdiger; Kempa, Stefan; Müller-Decker, Karin; Wiemann, Stefan
    Abrogating GPT2 in triple-negative breast cancer inhibits tumor growth and promotes autophagy
    In: International Journal of Cancer Vol. 148 (2021) Nr. 8, pp. 1993 - 2009
    ISSN: 0020-7136; 1097-0215
  • Körholz, Katharina; Ridinger, Johannes; Krunic, Damir; Najafi, Sara; Gerloff, Xenia F.; Frese, Karen; Meder, Benjamin; Peterziel, Heike; Vega-Rubin-de-Celis, Silvia; Witt, Olaf; Oehme, Ina
    Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma
    In: Cells Vol. 10 (2021) Nr. 5,
    ISSN: 2073-4409
  • Krysztofiak, Adam; Szymonowicz, Klaudia; Hlouschek, Julian; Xiang, Kexu; Waterkamp, Christoph; Larafa, Safa; Goetting, Isabell; Vega-Rubin-de-Celis, Silvia; Theiss, Carsten; Matschke, Veronika; Hoffmann, Daniel; Jendrossek, Verena; Matschke, Johann
    Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown
    In: iScience Vol. 24 (2021) Nr. 11,
    ISSN: 2589-0042
  • Vega-Rubín-de-Celis, Silvia; Kinch, Lisa; Peña-Llopis, Samuel
    Regulation of beclin 1-mediated autophagy by oncogenic tyrosine kinases
    In: International Journal of Molecular Sciences (IJMS) Vol. 21 (2020) Nr. 23, pp. 9210
    ISSN: 1422-0067; 1661-6596
  • Zhao, Ben; Dierichs, Laura; Gu, Jiang-Ning; Trajkovic-Arsic, Marija; Axel Hilger, Ralf; Savvatakis, Konstantinos; Vega-Rubín-de-Celis, Silvia; Liffers, Sven-Thorsten; Peña-Llopis, Samuel; Behrens, Diana; Hahn, Stephan; Siveke, Jens; Lueong, Smiths S.
    TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancer
    In: Cell Death Discovery Vol. 6 (2020) Nr. 1,
    ISSN: 2058-7716
  • Vega-Rubín-de-Celis, Silvia
    The Role of Beclin 1-Dependent Autophagy in Cancer
    In: Biology Vol. 9 (2020) Nr. 1, pp. 4
    ISSN: 2079-7737
  • Vega-Rubín-de-Celis, Silvia; Zou, Zhongju; Fernández, Álvaro F.; Ci, Bo; Kim, Min; Xiao, Guanghua; Xie, Yang; Levine, Beth
    Increased autophagy blocks HER2-mediated breast tumorigenesis
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 115 (2018) Nr. 16, pp. 4176 - 4181
    ISSN: 1091-6490; 0027-8424
  • Vega-Rubín-de-Celis, Silvia; Peña-Llopis, Samuel; Konda, Meghan; Brugarolas, James
    Multistep regulation of TFEB by MTORC1
    In: Autophagy Vol. 13 (2017) Nr. 3, pp. 464 - 472
    ISSN: 1554-8635; 1554-8627
  • Vega-Rubín-de-Celis, Silvia; Brugarolas, James
    DDIT4 (DNA-damage-inducible transcript 4)
    In: Atlas of Genetics and Cytogenetics in Oncology and Haematology Vol. 17 (2013) Nr. 6, pp. 404 - 410
  • Peña-Llopis, Samuel; Vega-Rubín-de-Celis, Silvia; Liao, Arnold; Leng, Nan; Pavía-Jiménez, Andrea; Wang, Shanshan; Yamasaki, Toshinari; Zhrebker, Leah; Sivanand, Sharanya; Spence, Patrick; Kinch, Lisa; Hambuch, Tina; Jain, Suneer; Lotan, Yair; Margulis, Vitaly; Sagalowsky, Arthur I.; Summerour, Pia Banerji; Kabbani, Wareef; Wong, S W Wendy; Grishin, Nick; Laurent, Marc; Xie, Xian-Jin; Haudenschild, Christian D.; Ross, Mark T.; Bentley, David R.; Kapur, Payal; Brugarolas, James
    BAP1 loss defines a new class of renal cell carcinoma
    In: Nature Genetics Vol. 44 (2012) Nr. 7, pp. 751 - 759
    ISSN: 1061-4036; 1546-1718
  • Wolff, Nicholas C.; Vega-Rubín-de-Celis, Silvia; Xie, Xian-Jin; Castrillon, Diego H.; Kabbani, Wareef; Brugarolas, James
    Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia
    In: Molecular and Cellular Biology Vol. 31 (2011) Nr. 9, pp. 1870 - 1884
    ISSN: 1098-5549; 0270-7306
  • Peña-Llopis, Samuel; Vega-Rubín-de-Celis, Silvia; Schwartz, Jacob C.; Wolff, Nicholas C.; Tran, Tram Anh T.; Zou, Lihua; Xie, Xian-Jin; Corey, David R.; Brugarolas, James
    Regulation of TFEB and V-ATPases by mTORC1
    In: The EMBO Journal Vol. 30 (2011) Nr. 16, pp. 3242 - 3258
    ISSN: 0261-4189; 1460-2075
  • Vega-Rubín-de-Celis, Silvia; Abdallah, Zeina; Kinch, Lisa; Grishin, Nick V.; Brugarolas, James; Zhang, Xuewu
    Structural analysis and functional implications of the negative mTORC1 regulator REDD1
    In: Biochemistry Vol. 49 (2010) Nr. 11, pp. 2491 - 2501
    ISSN: 0006-2960; 1520-4995
  • Diez, Amalia; Menoyo, David; Pérez-Benavente, Susana; Calduch-Giner, Josep A.; Vega-Rubín-de-Celis, Silvia; Obach, Alex; Favre-Krey, Laurence; Boukouvala, Evridiki; Leaver, Michael J.; Tocher, Douglas R.; Pérez-Sanchez, Jaume; Krey, Grigorios; Bautista, José M.
    Conjugated linoleic acid affects lipid composition, metabolism, and gene expression in gilthead sea bream (Sparus aurata L)
    In: The Journal of Nutrition Vol. 137 (2007) Nr. 6, pp. 1363 - 1369
    ISSN: 1541-6100; 0022-3166
  • Gómez-Requeni, Pedro; Calduch-Giner, Josep; Vega-Rubín-de-Celis, Silvia; Médale, Françoise; Kaushik, Sadasivam J.; Pérez-Sánchez, Jaume
    Regulation of the somatotropic axis by dietary factors in rainbow trout (Oncorhynchus mykiss)
    In: British Journal of Nutrition (BJN) Vol. 94 (2005) Nr. 3, pp. 353 - 361
    ISSN: 0007-1145; 1475-2662
  • Vega-Rubín-de-Celis, Silvia; Rojas, Pablo; Gómez-Requeni, Pedro; Albalat, Amaya; Gutiérrez, Joaquim; Médale, Françoise; Kaushik, Sadasivam J.; Navarro, Isabel; Pérez-Sánchez, Jaume
    Nutritional assessment of somatolactin function in gilthead sea bream (Sparus aurata) : Concurrent changes in somatotropic axis and pancreatic hormones
    In: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology Vol. 138 (2004) Nr. 4, pp. 533 - 542
    ISSN: 1095-6433; 1531-4332
  • Vega-Rubín-de-Celis, Silvia; Gómez-Requeni, Pedro; Pérez-Sánchez, Jaume
    Production and characterization of recombinantly derived peptides and antibodies for accurate determinations of somatolactin, growth hormone and insulin-like growth factor-I in European sea bass (Dicentrarchus labrax)
    In: General and Comparative Endocrinology Vol. 139 (2004) Nr. 3, pp. 266 - 277
    ISSN: 1095-6840; 0016-6480
  • Vega-Rubín-de-Celis, Silvia; Gómez, Pedro; Calduch-Giner, Josep Àlvar; Médale, Françoise; Pérez-Sánchez, Jaume
    Expression and characterization of European sea bass (Dicentrarchus labrax) somatolactin : Assessment of in vivo metabolic effects
    In: Marine Biotechnology Vol. 5 (2003) Nr. 1, pp. 92 - 101
    ISSN: 1436-2228; 1436-2236
  • Peyon, Pierre; Vega-Rubín-de-Celis, Silvia; Gómez-Requeni, Pedro; Zanuy, Silvia; Pérez-Sánchez, Jaume; Carrillo, Manuel
    In vitro effect of leptin on somatolactin release in the European sea bass (Dicentrarchus labrax) : Dependence on the reproductive status and interaction with NPY and GnRH
    In: General and Comparative Endocrinology Vol. 132 (2003) Nr. 2, pp. 284 - 292
    ISSN: 0016-6480; 1095-6840
  • Calduch-Giner, Josep A.; Mingarro, Mónica; Vega-Rubín-de-Celis, Silvia; Boujard, Daniel; Pérez-Sánchez, Jaume
    Molecular cloning and characterization of gilthead sea bream (Sparus aurata) growth hormone receptor (GHR) : Assessment of alternative splicing
    In: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology Vol. 136 (2003) Nr. 1, pp. 1 - 13
    ISSN: 1096-4959; 1879-1107; 0305-0491
  • Mingarro, Mónica; Vega-Rubín-de-Celis, Silvia; Astola, Antonio; Pendón, Carlos; Valdivia, Manuel Martínez; Pérez-Sánchez, Jaume
    Endocrine mediators of seasonal growth in gilthead sea bream (Sparus aurata) : The growth hormone and somatolactin paradigm
    In: General and Comparative Endocrinology Vol. 128 (2002) Nr. 2, pp. 102 - 111
    ISSN: 1095-6840; 0016-6480
  • Pérez-Sánchez, Jaume; Calduch-Giner, Josep Àlvar; Mingarro, Mónica; Vega-Rubín-de-Celis, Silvia; Gómez-Requeni, Pedro; Saera-Vila, Alfonso; Astola, Antonio; Valdivia, Manuel
    Overview of fish growth hormone family : New insights in genomic organization and heterogeneity of growth hormone receptors
    In: Fish Physiology and Biochemistry Vol. 27 (2002) Nr. 3-4, pp. 243 - 258
    ISSN: 0920-1742; 1573-5168