ZMB Member Silvia Vega-Rubín-de-Celis
ZMB Member
Silvia Vega-Rubín-de-Celis
Next ZMB-Member
Dr. Silvia Vega-Rubín-de-Celis
Junior Research Group
Autophagy in CancerInstitute of Cell Biology (Tumor Research)
University Hospital Essen
Virchowstr. 173
45122 Essen
- +49 201 723 3941
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- Publications
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- ZMB Research Program
Oncology
Research Overview
The research focus of my group revolves around understanding the role of autophagy in cancer and exploring the use of autophagy modulating agents as potential therapeutic targets in tumors. We undertake a variety of approaches, from understanding basic molecular biology mechanisms in cell lines and patient samples to ultimately translate the findings into the clinic.
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Publications
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TROP2 expression and SN38 antitumor activity in malignant pleural mesothelioma cells provide a rationale for antibody-drug conjugate therapyIn: Lung Cancer Vol. 178 (2023) pp. 237 - 246ISSN: 1872-8332; 0169-5002Online Full Text: dx.doi.org/
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Nintedanib and Dasatinib Treatments Induce Protective Autophagy as a Potential Resistance Mechanism in MPM CellsIn: Frontiers in Cell and Developmental Biology Vol. 10 (2022)ISSN: 2296-634XOnline Full Text: dx.doi.org/ Online Full Text (Open Access)
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A BAP1 synonymous mutation results in exon skipping, loss of function and worse patient prognosisIn: iScience Vol. 24 (2021) Nr. 3,ISSN: 2589-0042Online Full Text: dx.doi.org/ (Open Access)
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Abrogating GPT2 in triple-negative breast cancer inhibits tumor growth and promotes autophagyIn: International Journal of Cancer Vol. 148 (2021) Nr. 8, pp. 1993 - 2009ISSN: 0020-7136; 1097-0215Online Full Text: dx.doi.org/ (Open Access)
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Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in NeuroblastomaIn: Cells Vol. 10 (2021) Nr. 5,ISSN: 2073-4409Online Full Text: dx.doi.org/ (Open Access)
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Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdownIn: iScience Vol. 24 (2021) Nr. 11,ISSN: 2589-0042Online Full Text: dx.doi.org/ (Open Access)
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Regulation of beclin 1-mediated autophagy by oncogenic tyrosine kinasesIn: International Journal of Molecular Sciences (IJMS) Vol. 21 (2020) Nr. 23, pp. 9210ISSN: 1422-0067; 1661-6596Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancerIn: Cell Death Discovery Vol. 6 (2020) Nr. 1,ISSN: 2058-7716Online Full Text: dx.doi.org/ (Open Access)
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The Role of Beclin 1-Dependent Autophagy in CancerIn: Biology Vol. 9 (2020) Nr. 1, pp. 4ISSN: 2079-7737Online Full Text: dx.doi.org/ (Open Access)
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Increased autophagy blocks HER2-mediated breast tumorigenesisIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 115 (2018) Nr. 16, pp. 4176 - 4181ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/ (Open Access)
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Multistep regulation of TFEB by MTORC1In: Autophagy Vol. 13 (2017) Nr. 3, pp. 464 - 472ISSN: 1554-8635; 1554-8627Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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DDIT4 (DNA-damage-inducible transcript 4)In: Atlas of Genetics and Cytogenetics in Oncology and Haematology Vol. 17 (2013) Nr. 6, pp. 404 - 410Online Full Text: dx.doi.org/ (Open Access)
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BAP1 loss defines a new class of renal cell carcinomaIn: Nature Genetics Vol. 44 (2012) Nr. 7, pp. 751 - 759ISSN: 1061-4036; 1546-1718Online Full Text: dx.doi.org/ (Open Access)
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Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxiaIn: Molecular and Cellular Biology Vol. 31 (2011) Nr. 9, pp. 1870 - 1884ISSN: 1098-5549; 0270-7306Online Full Text: dx.doi.org/ (Open Access)
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Regulation of TFEB and V-ATPases by mTORC1In: The EMBO Journal Vol. 30 (2011) Nr. 16, pp. 3242 - 3258ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/ (Open Access)
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Structural analysis and functional implications of the negative mTORC1 regulator REDD1In: Biochemistry Vol. 49 (2010) Nr. 11, pp. 2491 - 2501ISSN: 0006-2960; 1520-4995Online Full Text: dx.doi.org/ (Open Access)
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Conjugated linoleic acid affects lipid composition, metabolism, and gene expression in gilthead sea bream (Sparus aurata L)In: The Journal of Nutrition Vol. 137 (2007) Nr. 6, pp. 1363 - 1369ISSN: 1541-6100; 0022-3166Online Full Text: dx.doi.org/ (Open Access)
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Regulation of the somatotropic axis by dietary factors in rainbow trout (Oncorhynchus mykiss)In: British Journal of Nutrition (BJN) Vol. 94 (2005) Nr. 3, pp. 353 - 361ISSN: 0007-1145; 1475-2662Online Full Text: dx.doi.org/ (Open Access)
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Nutritional assessment of somatolactin function in gilthead sea bream (Sparus aurata) : Concurrent changes in somatotropic axis and pancreatic hormonesIn: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology Vol. 138 (2004) Nr. 4, pp. 533 - 542ISSN: 1095-6433; 1531-4332Online Full Text: dx.doi.org/
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Production and characterization of recombinantly derived peptides and antibodies for accurate determinations of somatolactin, growth hormone and insulin-like growth factor-I in European sea bass (Dicentrarchus labrax)In: General and Comparative Endocrinology Vol. 139 (2004) Nr. 3, pp. 266 - 277ISSN: 1095-6840; 0016-6480Online Full Text: dx.doi.org/
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Expression and characterization of European sea bass (Dicentrarchus labrax) somatolactin : Assessment of in vivo metabolic effectsIn: Marine Biotechnology Vol. 5 (2003) Nr. 1, pp. 92 - 101ISSN: 1436-2228; 1436-2236Online Full Text: dx.doi.org/
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In vitro effect of leptin on somatolactin release in the European sea bass (Dicentrarchus labrax) : Dependence on the reproductive status and interaction with NPY and GnRHIn: General and Comparative Endocrinology Vol. 132 (2003) Nr. 2, pp. 284 - 292ISSN: 0016-6480; 1095-6840Online Full Text: dx.doi.org/
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Molecular cloning and characterization of gilthead sea bream (Sparus aurata) growth hormone receptor (GHR) : Assessment of alternative splicingIn: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology Vol. 136 (2003) Nr. 1, pp. 1 - 13ISSN: 1096-4959; 1879-1107; 0305-0491Online Full Text: dx.doi.org/
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Endocrine mediators of seasonal growth in gilthead sea bream (Sparus aurata) : The growth hormone and somatolactin paradigmIn: General and Comparative Endocrinology Vol. 128 (2002) Nr. 2, pp. 102 - 111ISSN: 1095-6840; 0016-6480Online Full Text: dx.doi.org/
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Overview of fish growth hormone family : New insights in genomic organization and heterogeneity of growth hormone receptorsIn: Fish Physiology and Biochemistry Vol. 27 (2002) Nr. 3-4, pp. 243 - 258ISSN: 0920-1742; 1573-5168Online Full Text: dx.doi.org/