ZMB Member Silvia Vega-Rubín-de-Celis
ZMB Member
Silvia Vega-Rubín-de-Celis
Next ZMB-Member
Dr. Silvia Vega-Rubín-de-Celis
Junior Research Group
Autophagy in CancerInstitute of Cell Biology (Tumor Research)
University Hospital Essen
Virchowstr. 173
45122 Essen
- +49 201 723 3941
- Website
- Publications
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- ZMB Research Program
Oncology
Research Overview
The research focus of my group revolves around understanding the role of autophagy in cancer and exploring the use of autophagy modulating agents as potential therapeutic targets in tumors. We undertake a variety of approaches, from understanding basic molecular biology mechanisms in cell lines and patient samples to ultimately translate the findings into the clinic.
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Publications
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HHLA2 activates c-Met and identifies patients for targeted therapy in hepatocellular carcinomaIn: Journal of Experimental & Clinical Cancer Research , Vol. 44 2025 , Nr. 1 , 153DOI (Open Access)
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Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinomaIn: Autophagy 2025 , in pressDOI (Open Access)
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GRB2 is a BECN1 interacting protein that regulates autophagyIn: Cell Death and Disease , Vol. 15 2024 , Nr. 1 , 14DOI, Online Full Text (Open Access)
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TROP2 expression and SN38 antitumor activity in malignant pleural mesothelioma cells provide a rationale for antibody-drug conjugate therapyIn: Lung Cancer , Vol. 178 2023 , pp. 237 - 246
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Nintedanib and Dasatinib Treatments Induce Protective Autophagy as a Potential Resistance Mechanism in MPM CellsIn: Frontiers in Cell and Developmental Biology , Vol. 10 2022 , 852812DOI, Online Full Text (Open Access)
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A BAP1 synonymous mutation results in exon skipping, loss of function and worse patient prognosisIn: iScience , Vol. 24 2021 , Nr. 3 , 102173DOI (Open Access)
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Abrogating GPT2 in triple-negative breast cancer inhibits tumor growth and promotes autophagyIn: International Journal of Cancer , Vol. 148 2021 , Nr. 8 , pp. 1993 - 2009DOI (Open Access)
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Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in NeuroblastomaIn: Cells , Vol. 10 2021 , Nr. 5 , 1001DOI (Open Access)
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Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdownIn: iScience , Vol. 24 2021 , Nr. 11 , 103366DOI (Open Access)
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Regulation of beclin 1-mediated autophagy by oncogenic tyrosine kinasesIn: International Journal of Molecular Sciences (IJMS) , Vol. 21 2020 , Nr. 23 , pp. 9210DOI, Online Full Text (Open Access)
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TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancerIn: Cell Death Discovery , Vol. 6 2020 , Nr. 1 , 12DOI (Open Access)
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The Role of Beclin 1-Dependent Autophagy in CancerIn: Biology , Vol. 9 2020 , Nr. 1 , pp. 4DOI (Open Access)
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Increased autophagy blocks HER2-mediated breast tumorigenesisIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 115 2018 , Nr. 16 , pp. 4176 - 4181DOI (Open Access)
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Multistep regulation of TFEB by MTORC1In: Autophagy , Vol. 13 2017 , Nr. 3 , pp. 464 - 472DOI (Open Access)
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DDIT4 (DNA-damage-inducible transcript 4)In: Atlas of Genetics and Cytogenetics in Oncology and Haematology , Vol. 17 2013 , Nr. 6 , pp. 404 - 410DOI (Open Access)
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BAP1 loss defines a new class of renal cell carcinomaIn: Nature Genetics , Vol. 44 2012 , Nr. 7 , pp. 751 - 759DOI (Open Access)
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Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxiaIn: Molecular and Cellular Biology (MCB) , Vol. 31 2011 , Nr. 9 , pp. 1870 - 1884DOI (Open Access)
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Regulation of TFEB and V-ATPases by mTORC1In: The EMBO Journal , Vol. 30 2011 , Nr. 16 , pp. 3242 - 3258DOI (Open Access)
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Structural analysis and functional implications of the negative mTORC1 regulator REDD1In: Biochemistry , Vol. 49 2010 , Nr. 11 , pp. 2491 - 2501DOI (Open Access)
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Conjugated linoleic acid affects lipid composition, metabolism, and gene expression in gilthead sea bream (Sparus aurata L)In: The Journal of Nutrition , Vol. 137 2007 , Nr. 6 , pp. 1363 - 1369DOI (Open Access)
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Regulation of the somatotropic axis by dietary factors in rainbow trout (Oncorhynchus mykiss)In: British Journal of Nutrition: BJN , Vol. 94 2005 , Nr. 3 , pp. 353 - 361DOI (Open Access)
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Nutritional assessment of somatolactin function in gilthead sea bream (Sparus aurata) : Concurrent changes in somatotropic axis and pancreatic hormonesIn: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology , Vol. 138 2004 , Nr. 4 , pp. 533 - 542
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Production and characterization of recombinantly derived peptides and antibodies for accurate determinations of somatolactin, growth hormone and insulin-like growth factor-I in European sea bass (Dicentrarchus labrax)In: General and Comparative Endocrinology , Vol. 139 2004 , Nr. 3 , pp. 266 - 277
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Expression and characterization of European sea bass (Dicentrarchus labrax) somatolactin : Assessment of in vivo metabolic effectsIn: Marine Biotechnology , Vol. 5 2003 , Nr. 1 , pp. 92 - 101
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In vitro effect of leptin on somatolactin release in the European sea bass (Dicentrarchus labrax) : Dependence on the reproductive status and interaction with NPY and GnRHIn: General and Comparative Endocrinology , Vol. 132 2003 , Nr. 2 , pp. 284 - 292
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Molecular cloning and characterization of gilthead sea bream (Sparus aurata) growth hormone receptor (GHR) : Assessment of alternative splicingIn: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology , Vol. 136 2003 , Nr. 1 , pp. 1 - 13
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Endocrine mediators of seasonal growth in gilthead sea bream (Sparus aurata) : The growth hormone and somatolactin paradigmIn: General and Comparative Endocrinology , Vol. 128 2002 , Nr. 2 , pp. 102 - 111
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Overview of fish growth hormone family : New insights in genomic organization and heterogeneity of growth hormone receptorsIn: Fish Physiology and Biochemistry , Vol. 27 2002 , Nr. 3-4 , pp. 243 - 258