ZMB Member Silvia Vega-Rubín-de-Celis

ZMB Member
Silvia Vega-Rubín-de-Celis

Next ZMB-Member

© UKE/Vega-Rubín-de-Celis

Dr. Silvia Vega-Rubín-de-Celis

Junior Research Group

Autophagy in Cancer

Institute of Cell Biology (Tumor Research)
University Hospital Essen
Virchowstr. 173
45122 Essen

Research Overview

The research focus of my group revolves around understanding the role of autophagy in cancer and exploring the use of autophagy modulating agents as potential therapeutic targets in tumors. We undertake a variety of approaches, from understanding basic molecular biology mechanisms in cell lines and patient samples to ultimately translate the findings into the clinic.
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Publications

    Journal articles

  • Vega-Rubín-de-Celis, Silvia; Kristani, Amanda; Kudla, Matthias; Mergener, Svenja; Corrochano-Ruiz, Andrés; Larafa, Safa; Montero-Vergara, Jetsy; Ahle, Laura-Marie; Will, Rainer; Lever, Mael; Grünwald, Viktor; Hadaschik, Boris; Jendrossek, Verena; Bechrakis, Nikolaos E.; Peña-Llopis, Samuel
    Autophagy suppression via SRC induction represents a therapeutic vulnerability for BAP1-mutant cancers
    In: Autophagy, 2025, in press
    DOI (Open Access)
  • Huang, Xubo; Fang, Runya; Pang, Yuqian; Zhang, Zhe; Huang, Jieru; Li, Yingchang; Yuan, Tao; Zeng, Yuyi; Yao, Ziying; Vega-Rubín-de-Celis, Silvia; Thinwa, Josephine; Zhang, Qisheng; Shen, Hao; Wang, Jiahong; Shen, Feng; Wei, Yongjie
    HHLA2 activates c-Met and identifies patients for targeted therapy in hepatocellular carcinoma
    In: Journal of Experimental & Clinical Cancer Research, Vol. 44, 2025, Nr. 1, 153
    DOI (Open Access)
  • Shi, Hao; Yang, Yajie; Gao, Jiwei; Kumar, Satendra; Xie, Hong; Chen, Ziqing; Lyu, Jiawen; Sihto, Harri; Koljonen, Virve; Vega-Rubín-de-Celis, Silvia; Vukojevic, Vladana; Farnebo, Filip; Björnhagen, Viveca; Höög, Anders; Juhlin, C. Christofer; Lee, Linkiat; Wickström, Malin; Becker, Jürgen; Johnsen, John Inge; Larsson, Catharina; Lui, Weng-Onn
    Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma
    In: Autophagy, Vol. 21, 2025, Nr. 7, pp. 1523 – 1543
    DOI (Open Access)
  • Montero-Vergara, Jetsy; Plachetta, Kira; Kinch, Lisa; Bernhardt, Stephan; Kashyap, Kriti; Levine, Beth; Thukral, Lipi; Vetter, Martina; Thomssen, Christoph; Wiemann, Stefan; Peña-Llopis, Samuel; Jendrossek, Verena; Vega-Rubin-de-Celis, Silvia
    GRB2 is a BECN1 interacting protein that regulates autophagy
    In: Cell Death and Disease, Vol. 15, 2024, Nr. 1, 14
    DOI, Online Full Text (Open Access)
  • Hegedüs, Luca; Okumus, Özlem; Mairinger, Fabian; Ploenes, Till; Reuter, Sebastian; Schuler, Martin; Welt, Anja; Vega-Rubin-de-Celis, Silvia; Theegarten, Dirk; Bankfalvi, Agnes; Aigner, Clemens; Hegedüs, Balazs
    TROP2 expression and SN38 antitumor activity in malignant pleural mesothelioma cells provide a rationale for antibody-drug conjugate therapy
    In: Lung Cancer, Vol. 178, 2023, pp. 237 – 246
    DOI
  • Hegedüs, Luca; Szücs, Kata D.; Kudla, Matthias; Heidenreich, Julian; Jendrossek, Verena; Peña-Llopis, Samuel; Garay, Tamas; Czirok, Andras; Aigner, Clemens; Plönes, Till; Vega-Rubin-de-Celis, Silvia; Hegedüs, Balazs
    Nintedanib and Dasatinib Treatments Induce Protective Autophagy as a Potential Resistance Mechanism in MPM Cells
    In: Frontiers in Cell and Developmental Biology, Vol. 10, 2022, 852812
    DOI, Online Full Text (Open Access)
  • Niersch, Jennifer; Vega-Rubín-de-Celis, Silvia; Bazarna, Anna; Mergener, Svenja; Jendrossek, Verena; Siveke, Jens T.; Peña-Llopis, Samuel
    A BAP1 synonymous mutation results in exon skipping, loss of function and worse patient prognosis
    In: iScience, Vol. 24, 2021, Nr. 3, 102173
    DOI (Open Access)
  • Mitra, Devina; Vega-Rubín-de-Celis, Silvia; Royla, Nadine; Bernhardt, Stephan; Wilhelm, Heike; Tarade, Nooraldeen; Poschet, Gernot; Buettner, Michael; Binenbaum, Ilona; Borgoni, Simone; Vetter, Martina; Kantelhardt, Eva Johanna; Thomssen, Christoph; Chatziioannou, Aristotelis; Hell, Rüdiger; Kempa, Stefan; Müller-Decker, Karin; Wiemann, Stefan
    Abrogating GPT2 in triple-negative breast cancer inhibits tumor growth and promotes autophagy
    In: International Journal of Cancer, Vol. 148, 2021, Nr. 8, pp. 1993 – 2009
    DOI (Open Access)
  • Körholz, Katharina; Ridinger, Johannes; Krunic, Damir; Najafi, Sara; Gerloff, Xenia F.; Frese, Karen; Meder, Benjamin; Peterziel, Heike; Vega-Rubin-de-Celis, Silvia; Witt, Olaf; Oehme, Ina
    Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma
    In: Cells, Vol. 10, 2021, Nr. 5, 1001
    DOI (Open Access)
  • Krysztofiak, Adam; Szymonowicz, Klaudia; Hlouschek, Julian; Xiang, Kexu; Waterkamp, Christoph; Larafa, Safa; Goetting, Isabell; Vega-Rubin-de-Celis, Silvia; Theiss, Carsten; Matschke, Veronika; Hoffmann, Daniel; Jendrossek, Verena; Matschke, Johann
    Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown
    In: iScience, Vol. 24, 2021, Nr. 11, 103366
    DOI (Open Access)
  • Vega-Rubín-de-Celis, Silvia; Kinch, Lisa; Peña-Llopis, Samuel
    Regulation of beclin 1-mediated autophagy by oncogenic tyrosine kinases
    In: International Journal of Molecular Sciences (IJMS), Vol. 21, 2020, Nr. 23, pp. 9210
    DOI, Online Full Text (Open Access)
  • Zhao, Ben; Dierichs, Laura; Gu, Jiang-Ning; Trajkovic-Arsic, Marija; Axel Hilger, Ralf; Savvatakis, Konstantinos; Vega-Rubín-de-Celis, Silvia; Liffers, Sven-Thorsten; Peña-Llopis, Samuel; Behrens, Diana; Hahn, Stephan; Siveke, Jens T.; Lueong, Smiths S.
    TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancer
    In: Cell Death Discovery, Vol. 6, 2020, Nr. 1, 12
    DOI (Open Access)
  • Vega-Rubín-de-Celis, Silvia
    The Role of Beclin 1-Dependent Autophagy in Cancer
    In: Biology, Vol. 9, 2020, Nr. 1, pp. 4
    DOI (Open Access)
  • Vega-Rubín-de-Celis, Silvia; Zou, Zhongju; Fernández, Álvaro F.; Ci, Bo; Kim, Min; Xiao, Guanghua; Xie, Yang; Levine, Beth
    Increased autophagy blocks HER2-mediated breast tumorigenesis
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 115, 2018, Nr. 16, pp. 4176 – 4181
    DOI (Open Access)
  • Vega-Rubín-de-Celis, Silvia; Peña-Llopis, Samuel; Konda, Meghan; Brugarolas, James
    Multistep regulation of TFEB by MTORC1
    In: Autophagy, Vol. 13, 2017, Nr. 3, pp. 464 – 472
    DOI, Online Full Text (Open Access)
  • Vega-Rubín-de-Celis, Silvia; Brugarolas, James
    DDIT4 (DNA-damage-inducible transcript 4)
    In: Atlas of Genetics and Cytogenetics in Oncology and Haematology, Vol. 17, 2013, Nr. 6, pp. 404 – 410
    DOI (Open Access)
  • Peña-Llopis, Samuel; Vega-Rubín-de-Celis, Silvia; Liao, Arnold; Leng, Nan; Pavía-Jiménez, Andrea; Wang, Shanshan; Yamasaki, Toshinari; Zhrebker, Leah; Sivanand, Sharanya; Spence, Patrick; Kinch, Lisa; Hambuch, Tina; Jain, Suneer; Lotan, Yair; Margulis, Vitaly; Sagalowsky, Arthur I.; Summerour, Pia Banerji; Kabbani, Wareef; Wong, S W Wendy; Grishin, Nick; Laurent, Marc; Xie, Xian-Jin; Haudenschild, Christian D.; Ross, Mark T.; Bentley, David R.; Kapur, Payal; Brugarolas, James
    BAP1 loss defines a new class of renal cell carcinoma
    In: Nature Genetics, Vol. 44, 2012, Nr. 7, pp. 751 – 759
    DOI (Open Access)
  • Wolff, Nicholas C.; Vega-Rubín-de-Celis, Silvia; Xie, Xian-Jin; Castrillon, Diego H.; Kabbani, Wareef; Brugarolas, James
    Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia
    In: Molecular and Cellular Biology (MCB), Vol. 31, 2011, Nr. 9, pp. 1870 – 1884
    DOI (Open Access)
  • Peña-Llopis, Samuel; Vega-Rubín-de-Celis, Silvia; Schwartz, Jacob C.; Wolff, Nicholas C.; Tran, Tram Anh T.; Zou, Lihua; Xie, Xian-Jin; Corey, David R.; Brugarolas, James
    Regulation of TFEB and V-ATPases by mTORC1
    In: The EMBO Journal, Vol. 30, 2011, Nr. 16, pp. 3242 – 3258
    DOI (Open Access)
  • Vega-Rubín-de-Celis, Silvia; Abdallah, Zeina; Kinch, Lisa; Grishin, Nick V.; Brugarolas, James; Zhang, Xuewu
    Structural analysis and functional implications of the negative mTORC1 regulator REDD1
    In: Biochemistry, Vol. 49, 2010, Nr. 11, pp. 2491 – 2501
    DOI (Open Access)
  • Diez, Amalia; Menoyo, David; Pérez-Benavente, Susana; Calduch-Giner, Josep A.; Vega-Rubín-de-Celis, Silvia; Obach, Alex; Favre-Krey, Laurence; Boukouvala, Evridiki; Leaver, Michael J.; Tocher, Douglas R.; Pérez-Sanchez, Jaume; Krey, Grigorios; Bautista, José M.
    Conjugated linoleic acid affects lipid composition, metabolism, and gene expression in gilthead sea bream (Sparus aurata L)
    In: The Journal of Nutrition, Vol. 137, 2007, Nr. 6, pp. 1363 – 1369
    DOI (Open Access)
  • Gómez-Requeni, Pedro; Calduch-Giner, Josep; Vega-Rubín-de-Celis, Silvia; Médale, Françoise; Kaushik, Sadasivam J.; Pérez-Sánchez, Jaume
    Regulation of the somatotropic axis by dietary factors in rainbow trout (Oncorhynchus mykiss)
    In: British Journal of Nutrition: BJN, Vol. 94, 2005, Nr. 3, pp. 353 – 361
    DOI (Open Access)
  • Vega-Rubín-de-Celis, Silvia; Rojas, Pablo; Gómez-Requeni, Pedro; Albalat, Amaya; Gutiérrez, Joaquim; Médale, Françoise; Kaushik, Sadasivam J.; Navarro, Isabel; Pérez-Sánchez, Jaume
    Nutritional assessment of somatolactin function in gilthead sea bream (Sparus aurata) : Concurrent changes in somatotropic axis and pancreatic hormones
    In: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, Vol. 138, 2004, Nr. 4, pp. 533 – 542
    DOI
  • Vega-Rubín-de-Celis, Silvia; Gómez-Requeni, Pedro; Pérez-Sánchez, Jaume
    Production and characterization of recombinantly derived peptides and antibodies for accurate determinations of somatolactin, growth hormone and insulin-like growth factor-I in European sea bass (Dicentrarchus labrax)
    In: General and Comparative Endocrinology, Vol. 139, 2004, Nr. 3, pp. 266 – 277
    DOI
  • Vega-Rubín-de-Celis, Silvia; Gómez, Pedro; Calduch-Giner, Josep Àlvar; Médale, Françoise; Pérez-Sánchez, Jaume
    Expression and characterization of European sea bass (Dicentrarchus labrax) somatolactin : Assessment of in vivo metabolic effects
    In: Marine Biotechnology, Vol. 5, 2003, Nr. 1, pp. 92 – 101
    DOI
  • Peyon, Pierre; Vega-Rubín-de-Celis, Silvia; Gómez-Requeni, Pedro; Zanuy, Silvia; Pérez-Sánchez, Jaume; Carrillo, Manuel
    In vitro effect of leptin on somatolactin release in the European sea bass (Dicentrarchus labrax) : Dependence on the reproductive status and interaction with NPY and GnRH
    In: General and Comparative Endocrinology, Vol. 132, 2003, Nr. 2, pp. 284 – 292
    DOI
  • Calduch-Giner, Josep A.; Mingarro, Mónica; Vega-Rubín-de-Celis, Silvia; Boujard, Daniel; Pérez-Sánchez, Jaume
    Molecular cloning and characterization of gilthead sea bream (Sparus aurata) growth hormone receptor (GHR) : Assessment of alternative splicing
    In: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, Vol. 136, 2003, Nr. 1, pp. 1 – 13
    DOI
  • Mingarro, Mónica; Vega-Rubín-de-Celis, Silvia; Astola, Antonio; Pendón, Carlos; Valdivia, Manuel Martínez; Pérez-Sánchez, Jaume
    Endocrine mediators of seasonal growth in gilthead sea bream (Sparus aurata) : The growth hormone and somatolactin paradigm
    In: General and Comparative Endocrinology, Vol. 128, 2002, Nr. 2, pp. 102 – 111
    DOI
  • Pérez-Sánchez, Jaume; Calduch-Giner, Josep Àlvar; Mingarro, Mónica; Vega-Rubín-de-Celis, Silvia; Gómez-Requeni, Pedro; Saera-Vila, Alfonso; Astola, Antonio; Valdivia, Manuel
    Overview of fish growth hormone family : New insights in genomic organization and heterogeneity of growth hormone receptors
    In: Fish Physiology and Biochemistry, Vol. 27, 2002, Nr. 3-4, pp. 243 – 258
    DOI
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