ZMB Member Andrea Vortkamp

ZMB Member
Andrea Vortkamp

Next ZMB-Member
portrait photo of ZMB member Andrea Vortkamp

Prof. Dr. Andrea Vortkamp

Group

Center of Medical Biotechnology (ZMB)
Faculty of Biology
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

Research Overview

Genetically induced skeletal malformations and degenerating bone diseases, like osteoarthritis and rheumatoid arthritis, represent major challenges of modern medicine. Both can result in severe pain, mobility restrictions and significantly impair the quality of human life. To identify the molecular basis of skeletal disorders and to pave the way for the development of targeted repair strategies we are investigating the mechanisms that regulate differentiation and growth of the skeletal elements during embryonic development and postnatal life. We are concentrating our research on the differentiation of chondrocytes in the growth plate of endochondral bones, the formation of bone tumors and the development and maintenance of the articular cartilage in the joints.

  • Signaling factors regulating chondrocyte differentiation
  • Gene regulation and Chromatin modification
  • Heparan sulfate: an extracellular regulator of growth factor signaling and cellular interactions
  • Degenerating Joint Diseases: Osteoarthrosis

Selected Publications

    Journal articles

  • Wülling, Manuela; Schneider, Sabine; Schröther, Verena A.; Waterkamp, Christoph; Hoffmann, Daniel; Vortkamp, Andrea
    Wnt5a is a transcriptional target of Gli3 and Trps1 at the onset of chondrocyte hypertrophy
    In: Developmental Biology Vol. 457 (2020) Nr. 1, pp. 104 - 118
    ISSN: 0012-1606; 1095-564X
  • Grüneboom, Anika; Hawwari, Ibrahim; Weidner, Daniela; Culemann, Stephan; Müller, Sylvia; Henneberg, Sophie; Brenzel, Alexandra; Merz, Simon; Bornemann, Lea; Zec, Kristina; Wülling, Manuela; Kling, Lasse; Hasenberg, Mike; Voortmann, Sylvia; Lang, Stefanie; Baum, Wolfgang; Ohs, Alexandra; Kraff, Oliver; Quick, Harald H.; Jäger, Marcus; Landgraeber, Stefan; Dudda, Marcel; Danuser, Renzo; Stein, Jens V.; Rohde, Manfred; Gelse, Kolja; Garbe, Annette I.; Adamczyk, Alexandra; Westendorf, Astrid; Hoffmann, Daniel; Christiansen, Silke; Engel, Daniel Robert; Vortkamp, Andrea; Krönke, Gerhard; Herrmann, Martin; Kamradt, Thomas; Schett, Georg; Hasenberg, Anja; Gunzer, Matthias
    A network of trans-cortical capillaries as mainstay for blood circulation in long bones
    In: Nature Metabolism Vol. 1 (2019) Nr. 2, pp. 236 - 250
    ISSN: 2522-5812
  • Wülling, Manuela; Vortkamp, Andrea
    A newly discovered stem cell that keeps bones growing
    In: Nature Vol. 567 (2019) Nr. 7747, pp. 178 - 179
    ISSN: 0028-0836; 1476-4687
  • Jones, Kevin B.; Piombo, Virginia; Searby, Charles; Kurriger, Gail; Yang, Baoli; Grabellus, Florian; Roughley, Peter J.; Morcuende, Jose A.; Buckwalter, Joseph A.; Capecchi, Mario R.; Vortkamp, Andrea; Sheffield, Val C.
    A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 107 (2010) Nr. 5, pp. 2054 - 2059
    ISSN: 1091-6490; 0027-8424
  • Detsch, Rainer; Hagmeyer, Daniel; Neumann, Markus C; Schaefer, Susannne; Vortkamp, Andrea; Wülling, Manuela; Ziegler, Günter; Epple, Matthias
    The resorption of nanocrystalline calcium phosphates by osteoclast-like cells
    In: Acta Biomaterialia Vol. 6 (2010) Nr. 8, pp. 3223 - 3233
    ISSN: 1878-7568; 1742-7061
  • Wülling, Manuela; Kaiser, Frank J.; Buelens, Laetitia; Braunholz, Diana; Shivdasani, Ramesh A.; Depping, Reinhard; Vortkamp, Andrea
    Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3
    In: Developmental Biology Vol. 328 (2009) Nr. 1, pp. 40 - 53
    ISSN: 0012-1606
  • Probst, Barbara; Rock, Rebecca; Gessler, Manfred; Vortkamp, Andrea; Püschel, Andreas W.
    The rodent Four-jointed ortholog Fjx1 regulates dendrite extension
    In: Developmental Biology Vol. 312 (2007) Nr. 1, pp. 461 - 470
    ISSN: 0012-1606
  • Didt-Koziel, L.; Wülling, Manuela; Schneider, S.; Vortkamp, Andrea
    Gli3 has repressing and activating functions downstream of Ihh in regulating two distinct steps of chondrocyte differentiation
    In: Development Vol. 132 (2005) pp. 5249 - 5260
  • Minina, E.; Wenzel, M.; Kreschel, K.S.; Gaffield, W.; McMahon, A.P.; Vortkamp, A.
    BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation.
    In: Development Vol. 128 (2001) pp. 4523 - 4534
  • Schimmang, T.; Lemaistre, M.; Vortkamp, A.; Ruther, U.
    Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt).
    In: Development Vol. 116 (1992) pp. 799 - 804
  • Vortkamp, Andrea; Gessler, Manfred; Grzeschik, Karl-Heinz
    GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families.
    In: Nature Vol. 352 (1991) Nr. 8. August, pp. 535 - 540
    ISSN: 0028-0836; 1476-4687