ZMB Member Andrea Vortkamp
ZMB Member
Andrea Vortkamp
Next ZMB-Member
Prof. Dr. Andrea Vortkamp
Group
Developmental Biology
Center of Medical Biotechnology (ZMB)
Faculty of Biology
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen
- +49 201 183 4298
- Selected Publications
- Publication Metrics
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- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
Genetically induced skeletal malformations and degenerating bone diseases, like osteoarthritis and rheumatoid arthritis, represent major challenges of modern medicine. Both can result in severe pain, mobility restrictions and significantly impair the quality of human life. To identify the molecular basis of skeletal disorders and to pave the way for the development of targeted repair strategies we are investigating the mechanisms that regulate differentiation and growth of the skeletal elements during embryonic development and postnatal life. We are concentrating our research on the differentiation of chondrocytes in the growth plate of endochondral bones, the formation of bone tumors and the development and maintenance of the articular cartilage in the joints.
- Signaling factors regulating chondrocyte differentiation
- Gene regulation and Chromatin modification
- Heparan sulfate: an extracellular regulator of growth factor signaling and cellular interactions
- Degenerating Joint Diseases: Osteoarthrosis
Selected Publications
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Wnt5a is a transcriptional target of Gli3 and Trps1 at the onset of chondrocyte hypertrophyIn: Developmental Biology Vol. 457 (2020) Nr. 1, pp. 104 - 118
ISSN: 0012-1606; 1095-564XOnline Full Text: dx.doi.org/ (Open Access) -
A network of trans-cortical capillaries as mainstay for blood circulation in long bonesIn: Nature Metabolism Vol. 1 (2019) Nr. 2, pp. 236 - 250
ISSN: 2522-5812Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
A newly discovered stem cell that keeps bones growingIn: Nature Vol. 567 (2019) Nr. 7747, pp. 178 - 179
ISSN: 0028-0836; 1476-4687Online Full Text: dx.doi.org/ -
A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytesIn: Proceedings of the National Academy of Sciences of the United States of America Vol. 107 (2010) Nr. 5, pp. 2054 - 2059
ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
The resorption of nanocrystalline calcium phosphates by osteoclast-like cellsIn: Acta Biomaterialia Vol. 6 (2010) Nr. 8, pp. 3223 - 3233
ISSN: 1878-7568; 1742-7061Online Full Text: dx.doi.org/ -
Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3In: Developmental Biology Vol. 328 (2009) Nr. 1, pp. 40 - 53
ISSN: 0012-1606Online Full Text: dx.doi.org/ -
The rodent Four-jointed ortholog Fjx1 regulates dendrite extensionIn: Developmental Biology Vol. 312 (2007) Nr. 1, pp. 461 - 470
ISSN: 0012-1606Online Full Text: dx.doi.org/ -
Gli3 has repressing and activating functions downstream of Ihh in regulating two distinct steps of chondrocyte differentiationIn: Development Vol. 132 (2005) pp. 5249 - 5260
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BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation.In: Development Vol. 128 (2001) pp. 4523 - 4534
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Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt).In: Development Vol. 116 (1992) pp. 799 - 804
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GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families.In: Nature Vol. 352 (1991) Nr. 8. August, pp. 535 - 540
ISSN: 0028-0836; 1476-4687