ZMB Member Ivo Bendix
ZMB Member
Ivo Bendix
Next ZMB-Member
Prof. Dr. Ivo Bendix
Pediatrics Clinic I
University Hospital Essen
Hufelandstr. 55
45122 Essen
- +49 201 723 0
- Website
- Publications
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- Publication Metrics
- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
The questions of the experimental perinatal neurosciences are aimed at uncovering cellular and molecular mechanisms of typical diseases of premature babies and sick newborns, with the integrity of the central nervous system being the focus of research.
Publications
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A Novel Model for Simultaneous Evaluation of Hyperoxia-Mediated Brain and Lung Injury in Neonatal RatsIn: Cells, Vol. 14, 2025, Nr. 6, pp. 443DOI (Open Access)
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Hypoxic-ischemic brain injury in neonatal mice sequentially recruits neutrophils with dichotomous phenotype and functionIn: Nature Communications, Vol. 16, 2025, Nr. 1, 9696DOI (Open Access)
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Prenatal inflammation exacerbates hyperoxia-induced neonatal brain injuryIn: Journal of Neuroinflammation, Vol. 22, 2025, Nr. 1, 57DOI (Open Access)
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Prolonged Exposure to Neonatal Hyperoxia Impairs Neuronal and Oligodendrocyte Maturation Associated with Long-Lasting Neuroinflammatory Responses in Juvenile MiceIn: Cells, Vol. 14, 2025, Nr. 15, 1141DOI, Online Full Text (Open Access)
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Oxygen and HIF1α-dependent SDF1 expression in primary astrocytesIn: Developmental Neurobiology, Vol. 84, 2024, Nr. 3, pp. 113 – 127DOI (Open Access)
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Extracellular vesicles from immortalized mesenchymal stromal cells protect against neonatal hypoxic-ischemic brain injuryIn: Inflammation and Regeneration, Vol. 43, 2023, Nr. 1, 24DOI, Online Full Text (Open Access)
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Growth-Restricted Fetuses and Offspring Reveal Adverse Sex-Specific Metabolic Responses in Preeclamptic Mice Expressing Human sFLT1In: International Journal of Molecular Sciences (IJMS), Vol. 24, 2023, Nr. 8, 6885DOI, Online Full Text (Open Access)
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Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injuryIn: Journal of Neuroinflammation, Vol. 20, 2023, Nr. 1, 280DOI, Online Full Text (Open Access)
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Perinatal Hyperoxia and Developmental Consequences on the Lung-Brain AxisIn: Oxidative Medicine and Cellular Longevity, 2022, 5784146DOI (Open Access)
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Peripheral immune cells and perinatal brain injury : A double-edged sword?In: Pediatric Research, Vol. 91, 2022, Nr. 2, pp. 392 – 403DOI (Open Access)
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Regulatory T Cells Contribute to Sexual Dimorphism in Neonatal Hypoxic-Ischemic Brain InjuryIn: Stroke, Vol. 53, 2022, Nr. 2, pp. 381 – 390DOI (Open Access)
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Systemic Maternal Human sFLT1 Overexpression Leads to an Impaired Foetal Brain Development of Growth-Restricted Foetuses upon Experimental PreeclampsiaIn: Oxidative Medicine and Cellular Longevity, Vol. 2022, 2022, 3024032DOI, Online Full Text (Open Access)
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Taste-immune associative learning amplifies immunopharmacological effects and attenuates disease progression in a rat glioblastoma modelIn: Brain, Behavior and Immunity, Vol. 106, 2022, pp. 270 – 279DOI (Open Access)
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The Impact of Increased Maternal sFlt-1/PlGF Ratio on Motor Outcome of Preterm InfantsIn: Frontiers in Endocrinology, Vol. 13, 2022, 913514DOI, Online Full Text (Open Access)
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Circulating Maternal sFLT1 (Soluble fms-Like Tyrosine Kinase-1) Is Sufficient to Impair Spiral Arterial Remodeling in a Preeclampsia Mouse ModelIn: Hypertension, Vol. 78, 2021, Nr. 4, pp. 1067 – 1079DOI (Open Access)
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Hyperoxia Leads to Transient Endocrine Alterations in the Neonatal Rat During Postnatal DevelopmentIn: Frontiers in Pediatrics, Vol. 9, 2021, 723928DOI, Online Full Text (Open Access)
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Hypothermia modulates myeloid cell polarization in neonatal hypoxic–ischemic brain injuryIn: Journal of Neuroinflammation, Vol. 18, 2021, Nr. 1, 266DOI, Online Full Text (Open Access)
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Neurobehavioral effects in rats with experimentally induced glioblastoma after treatment with the mTOR-inhibitor rapamycinIn: Neuropharmacology, Vol. 184, 2021, 108424
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Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia-ischemiaIn: Brain, Behavior and Immunity, Vol. 92, 2021, pp. 234 – 244DOI (Open Access)
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Treatment with the calcineurin inhibitor and immunosuppressant cyclosporine A impairs sensorimotor gating in Dark Agouti ratsIn: Psychopharmacology, Vol. 238, 2021, Nr. 4, pp. 1047 – 1057DOI (Open Access)
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Involvement of CXCL1/CXCR2 During Microglia Activation Following Inflammation-Sensitized Hypoxic-Ischemic Brain Injury in Neonatal RatsIn: Frontiers in Neurology, Vol. 11, 2020, pp. 540878DOI, Online Full Text (Open Access)
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Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Neuroinflammation, Promote Neural Cell Proliferation and Improve Oligodendrocyte Maturation in Neonatal Hypoxic-Ischemic Brain InjuryIn: Frontiers in Cellular Neuroscience, Vol. 14, 2020, pp. 601176DOI, Online Full Text (Open Access)
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Prevention of Oxygen-Induced Inflammatory Lung Injury by Caffeine in Neonatal RatsIn: Oxidative Medicine and Cellular Longevity, 2020, pp. 3840124DOI (Open Access)
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RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent modelsIn: The Journal of Clinical Investigation (JCI), Vol. 130, 2020, Nr. 6, pp. 2928 – 2942DOI, Online Full Text (Open Access)
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Repetitive Erythropoietin Treatment Improves Long-Term Neurocognitive Outcome by Attenuating Hyperoxia-Induced Hypomyelination in the Developing BrainIn: Frontiers in Neurology, Vol. 11, 2020, pp. 804DOI, Online Full Text (Open Access)
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White Matter Brain Development after Exposure to Circulating Cell-Free Hemoglobin and Hyperoxia in a Rat Pup ModelIn: Developmental Neuroscience, Vol. 41, 2020, Nr. 3-4, pp. 234 – 246DOI (Open Access)
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Adverse neuropsychiatric development following perinatal brain injury : from a preclinical perspectiveIn: Pediatric Research, Vol. 85, 2019, Nr. 2, pp. 198 – 215
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Detrimental Impact of Energy Drink Compounds on Developing Oligodendrocytes and NeuronsIn: Cells, Vol. 8, 2019, Nr. 11, pp. 1381DOI, Online Full Text (Open Access)
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Early pro-inflammatory microglia activation after inflammation-sensitized hypoxic-ischemic brain injury in neonatal ratsIn: Frontiers in Cellular Neuroscience, Vol. 13, 2019, pp. 237DOI (Open Access)
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Diabetes mellitus in pregnancy leads to growth restriction and epigenetic modification of the Srebf2 gene in rat fetusesIn: Hypertension, Vol. 71, 2018, Nr. 5, pp. 911 – 920DOI (Open Access)
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Interaction between hypothermia and delayed mesenchymal stem cell therapy in neonatal hypoxic-ischemic brain injuryIn: Brain, Behavior and Immunity, Vol. 70, 2018, pp. 118 – 130DOI (Open Access)
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Peripheral T cell depletion by FTY720 exacerbates hypoxic-ischemic brain injury in neonatal miceIn: Frontiers in Immunology, Vol. 9, 2018, pp. 1696DOI (Open Access)
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Protection of oligodendrocytes through neuronal overexpression of the small GTPase ras in hyperoxia-induced neonatal brain injuryIn: Frontiers in Neurology, Vol. 9, 2018, pp. 175DOI, Online Full Text (Open Access)
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Repeated systemic treatment with rapamycin affects behavior and amygdala protein expression in ratsIn: The International Journal of Neuropsychopharmacology, Vol. 21, 2018, Nr. 6, pp. 595 – 602DOI (Open Access)
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Caffeine protects against anticonvulsant-induced neurotoxicity in the developing rat brainIn: Neurotoxicity Research, Vol. 32, 2017, Nr. 3, pp. 460 – 472
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Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic InjuryIn: BioMed Research International, 2017, 2924848DOI (Open Access)
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Hyperoxia and the immature brainIn: Developmental Neuroscience, Vol. 38, 2017, Nr. 5, pp. 311 – 330DOI (Open Access)
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Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injuryIn: Brain, Behavior and Immunity, Vol. 60, 2017, pp. 220 – 232DOI (Open Access)
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Sildenafil Enhances Quantity of Immature Neurons and Promotes Functional Recovery in the Developing Ischemic Mouse BrainIn: Developmental Neuroscience, Vol. 39, 2017, Nr. 1-4, pp. 287 – 297
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Dose-dependent effects of levetiracetam after hypoxia and hypothermia in the neonatal mouse brainIn: Brain Research, Vol. 1646, 2016, pp. 116 – 124
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ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade GliomasIn: Molecular Cancer Therapeutics, Vol. 15, 2016, Nr. 8, pp. 1975 – 1987DOI (Open Access)
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Endogenous hypothermic response to hypoxia reduces brain injury : Implications for modeling hypoxic-ischemic encephalopathy and therapeutic hypothermia in neonatal miceIn: Experimental Neurology, Vol. 283, Part A, 2016, pp. 264 – 275DOI (Open Access)
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Erythropoietin Restores Long-Term Neurocognitive Function Involving Mechanisms of Neuronal Plasticity in a Model of Hyperoxia-Induced Preterm Brain InjuryIn: Oxidative Medicine and Cellular Longevity, 2016, pp. 9247493DOI (Open Access)
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Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxiaIn: Brain, Behavior and Immunity, Vol. 52, 2016, pp. 106 – 119DOI (Open Access)
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Transient inhibition of protein synthesis in the rat insular cortex delays extinction of conditioned taste aversion with cyclosporine AIn: Neurobiology of Learning and Memory, Vol. 133, 2016, pp. 129 – 135
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Tumor necrosis factor-inducible gene 6 protein : A novel neuroprotective factor against inflammation-induced developmental brain injuryIn: Experimental Neurology, Vol. 279, 2016, pp. 283 – 289DOI (Open Access)
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Neuroprotective Effect of Dexmedetomidine on Hyperoxia-Induced Toxicity in the Neonatal Rat BrainIn: Oxidative Medicine and Cellular Longevity, Vol. 2015, 2015, pp. 530371DOI (Open Access)
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Oxygen Sensitivity of Placental Trophoblast Connexins 43 and 46 : A Role in Preeclampsia?In: Journal of Cellular Biochemistry, Vol. 116, 2015, Nr. 12, pp. 2924 – 2937
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Regulatory T Cells Ameliorate Intrauterine Growth Retardation in a Transgenic Rat Model for PreeclampsiaIn: Hypertension, Vol. 65, 2015, Nr. 6, pp. 1298 – 1306DOI (Open Access)
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Inhibition of Acetylcholinesterase Modulates NMDA Receptor Antagonist Mediated Alterations in the Developing BrainIn: International Journal of Molecular Sciences (IJMS), Vol. 15, 2014, Nr. 3, pp. 3784 – 3798DOI (Open Access)
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Modulation of Dendritic Cell Immunobiology via Inhibition of 3-Hydroxy-3-Methylglutaryl-CoA (HMG-CoA) ReductaseIn: PLoS ONE, Vol. 9, 2014, Nr. 7, pp. e100871DOI (Open Access)
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Neuroblastoma in dialog with its stroma : NTRK1 is a regulator of cellular cross-talk with Schwann cellsIn: OncoTarget, Vol. 5, 2014, Nr. 22, pp. 11180 – 11192DOI (Open Access)
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Sphingosin-1-phosphate-receptor modulation reduces hyperoxia mediated brain injuryIn: Journal of Neuroimmunology, Vol. 275, 2014, Nr. 1-2, pp. 114
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CEACAM1 Expression in Oligodendrocytes of the Developing Rat Brain Shows a Spatiotemporal Relation to Myelination and Is Altered in a Model of Encephalopathy of PrematurityIn: Developmental Neuroscience, Vol. 35, 2013, Nr. 2-3, pp. 226 – 240
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Effect of Propofol in the Immature Rat Brain on Short- and Long-Term Neurodevelopmental OutcomeIn: PLoS ONE, Vol. 8, 2013, Nr. 5, pp. e64480DOI, Online Full Text (Open Access)
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Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brainIn: Neonatology, Vol. 103, 2013, Nr. 1, pp. 35 – 43
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Oxygen toxicity is reduced by acetylcholinesterase inhibition in the developing rat brainIn: Developmental Neuroscience, Vol. 35, 2013, Nr. 2-3, pp. 255 – 264
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Strategies for repair of white matter: Influence of osmolarity and microglia on proliferation and apoptosis of oligodendrocyte precursor cells in different basal culture mediaIn: Frontiers in Cellular Neuroscience, Vol. 7, 2013, pp. 277
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Erythropoietin Modulates Autophagy Signaling in the Developing Rat Brain in an In Vivo Model of Oxygen-ToxicityIn: International Journal of Molecular Sciences (IJMS), Vol. 13, 2012, Nr. 10, pp. 12939 – 12951DOI, Online Full Text (Open Access)
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Hyperoxia changes the balance of the thioredoxin/peroxiredoxin system in the neonatal rat brainIn: Brain Research, Vol. 1484, 2012, pp. 68 – 75
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Interaction of Inflammation and Hyperoxia in a Rat Model of Neonatal White Matter DamageIn: PLoS ONE, Vol. 7, 2012, Nr. 11, pp. e49023DOI, Online Full Text (Open Access)
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Interaction of inflammation and hyperoxia in a rat model of neonatal white matter damageIn: Journal of Neuroimmunology, Vol. 253, 2012, Nr. 1-2, pp. 45 – 45
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Prevention of neonatal oxygen-induced brain damage by reduction of intrinsic apoptosisIn: Cell Death and Disease, Vol. 3, 2012, Nr. 1, e250DOI (Open Access)
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Impact of Experimental Neonatal Propofol Anaesthesia on Neurodevelopmental Short- and Long-Term OutcomeIn: Pediatric Research, Vol. 70, 2011, pp. 31 – 31
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111 Impact of the Caspase-2 Inhibitor Trp601 on Apoptotic Signaling in the Developing Brain During HyperoxiaIn: Pediatric Research, Vol. 68, 2010, Nr. Suppl. 1, pp. 59 – 59
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113 The Apoptotic Effect of Propofol in Immature Rat Brain and Possible Neuroprotection by ErythropoietinIn: Pediatric Research, Vol. 68, 2010, Nr. Suppl. 1, pp. 60 – 60
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Erythropoietin attenuates hyperoxia-induced oxidative stress in the developing rat brainIn: Brain, Behavior and Immunity, Vol. 24, 2010, Nr. 5, pp. 792 – 799
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MAPK3 deficiency drives autoimmunity via DC armingIn: European Journal of Immunology, Vol. 40, 2010, Nr. 5, pp. 1486 – 1495
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Neurotoxic effects of MDMA (Ecstasy) on the developing rodent brainIn: Developmental Neuroscience, Vol. 32, 2010, Nr. 3, pp. 197 – 207
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Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous systemIn: Nature Medicine, Vol. 15, 2009, Nr. 7, pp. 788 – 793
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Geranylgeranylation but not GTP-loading of Rho GTPases determines T cell functionIn: Science Signaling, Vol. 1, 2008, Nr. 12
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Sirt1 contributes critically to the redox-dependent fate of neural progenitorsIn: Nature Cell Biology, Vol. 10, 2008, Nr. 4, pp. 385 – 394
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Geranylgeranylation but not GTP loading determines rho migratory function in T cellsIn: The Journal of Immunology, Vol. 179, 2007, Nr. 9, pp. 6024 – 6032
