Jadwiga Jablonska-Koch

ZMB Member
Jadwiga Jablonska-Koch

Next ZMB-Member
portrait photo of ZMB member Jadwiga Jablonska-Koch
© Koch/UKE

Prof. Dr. Jadwiga Jablonska-Koch

Group

Otorhinolaryngology (ENT)

ENT Department
West German Cancer Center (WTZ)
German Cancer Research Center (DKFZ), Partnersite Essen/Düsseldorf
University Hospital Essen
45147 Essen

Research Overview

We focus on the myeloid cell/ neutrophil-dependent immunoregulatory mechanisms that are responsible for the progression of cancerogenesis and inflammation. We study the molecular mechanisms involved in neutrophil polarization, mobilization and activation, but also complex interaction between regulatory myeloid cells, such as neutrophils, monocytes/macrophages and DCs.
Moreover, we are interested in overall neutrophil biology, i.e. development, differentiation, activation, migration and responses to various inflammatory stimuli in disease. We analyze the role of multiple cytokines (with focus on type I interferons) and growth factors (e.g. G-CSF) in the regulation of emergency myelopoiesis, and neutrophil polarization and homing. Over the last years we have established and worked on the following main research themes:

  1. Neutrophil heterogeneity and immunoregulatory activity in disease
  2. Identification of intracellular factors/signaling pathways contributing to the tumorigenic transformation of neutrophils
  3. Neutrophil-mediated regulation of angiogenesis
  4. Type I interferons (IFNs) as immunomodulators
  5. Exosome-mediated suppression of immune responses in tumor
  6. The impact of tumor-mediated immunosuppression on the susceptibility to bacterial infections
Read more

Selected Publications

    Journal articles

  • Zec, Kristina; Thiebes, Stephanie; Bottek, Jenny; Siemes, Devon; Spangenberg, Philippa; Trieu, Duc Viet; Kirstein, Nils; Subramaniam, Nirojah; Christ, Robin; Klein, Diana; Jendrossek, Verena; Loose, Maria; Wagenlehner, Florian; Jablonska, Jadwiga; Bracht, Thilo; Sitek, Barbara; Budeus, Bettina; Klein-Hitpaß, Ludger; Theegarten, Dirk; Shevchuk, Olga; Engel, Daniel Robert
    Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infection
    In: Frontiers in Immunology Vol. 14 (2023) 1227191
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Wandrey, Madita; Jablonska, Jadwiga; Stauber, Roland H.; Gül, Désirée
    Exosomes in Cancer Progression and Therapy Resistance : Molecular Insights and Therapeutic Opportunities
    In: Life Vol. 13 (2023) Nr. 10, 2033
    Online Full Text: dx.doi.org/ (Open Access)
  • Martins Nascentes Melo, Luiza; Herrera-Rios, Dayana; Hinze, Daniel; Löffek, Stefanie; Oezel, Irem; Turiello, Roberta; Klein, Juliane; Leonardelli, Sonia; Westedt, Isa-Vanessa; Al-Matary, Yahya; Egea-Rodriguez, Sara; Brenzel, Alexandra; Bau, Maja; Sucker, Antje; Hadaschik, Eva; Wirsdörfer, Florian; Hanenberg, Helmut; Uhlenbrock, Niklas; Rauh, Daniel; Poźniak, Joanna; Rambow, Florian; Marine, Jean-Christophe; Effern, Maike; Glodde, Nicole; Schadendorf, Dirk; Jablonska, Jadwiga; Hölzel, Michael; Helfrich, Iris
    Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma
    In: Journal for ImmunoTherapy of Cancer Vol. 11 (2023) Nr. 4, e004150
    Online Full Text: dx.doi.org/ (Open Access)
  • Duerig, Inga; Pylaeva, Ekaterina; Ozel, Irem; Wainwright, Sami; Thiel, Ilona; Bordbari, Sharareh; Domnich, Maksim; Siakaeva, Elena; Lakomek, Antonia; Toppe, Felicia; Schleupner, Carolin; Geisthoff, Urban; Lang, Stephan; Droege, Freya; Jablonska, Jadwiga
    Nonfunctional TGF-β/ALK1/ENG signaling pathway supports neutrophil proangiogenic activity in hereditary hemorrhagic telangiectasia
    In: Journal of Leukocyte Biology (JLB) Vol. 114 (2023) Nr. 6, pp. 639 - 650
    Online Full Text: dx.doi.org/ (Open Access)
  • Tengler, Luisa; Schütz, Julia; Tiedtke, Moritz; Jablonska, Jadwiga; Theodoraki, Marie-Nicole; Nitschke, Katja; Weiß, Christel; Seiz, Elena; Affolter, Annette; Jungbauer, Frederic; Lammert, Anne; Rotter, Nicole; Ludwig, Sonja
    Plasma-derived small extracellular vesicles unleash the angiogenic potential in head and neck cancer patients
    In: Molecular Medicine Vol. 29 (2023) Nr. 1, 69
    Online Full Text: dx.doi.org/ (Open Access)
  • Pylaeva, Ekaterina; Jablonska, Jadwiga
    Sellhi neutrophils : A key to triumph in cancer therapy
    In: Signal Transduction and Targeted Therapy Vol. 8 (2023) Nr. 1, 421
    Online Full Text: dx.doi.org/ (Open Access)
  • Wrobeln, Anna; Leu, Tristan; Jablonska, Jadwiga; Geisthoff, Urban; Lang, Stephan; Fandrey, Joachim; Droege, Freya
    Altered hypoxia inducible factor regulation in hereditary haemorrhagic telangiectasia
    In: Scientific Reports Vol. 12 (2022) Nr. 1, 5877
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Pylaeva, Ekaterina; Korschunow, Georg; Spyra, Ilona; Bordbari, Sharareh; Siakaeva, Elena; Ozel, Irem; Domnich, Maksim; Squire, Anthony; Hasenberg, Anja; Thangavelu, Kruthika; Hussain, Timon; Goetz, Moritz; Lang, Karl S.; Gunzer, Matthias; Hansen, Wiebke; Buer, Jan; Bankfalvi, Agnes; Lang, Stephan; Jablonska, Jadwiga
    During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes
    In: Cell Reports Vol. 40 (2022) Nr. 7, 111171
    Online Full Text: dx.doi.org/ (Open Access)
  • Chetty, Venkatesh Kumar; Ghanam, Jamal; Anchan, Srishti; Reinhardt, Katarina; Brenzel, Alexandra; Gelléri, Márton; Cremer, Christoph; Grueso-Navarro, Elena; Schneider, Markus; von Neuhoff, Nils; Reinhardt, Dirk; Jablonska, Jadwiga; Nazarenko, Irina; Thakur, Basant Kumar
    Efficient Small Extracellular Vesicles (EV) Isolation Method and Evaluation of EV-Associated DNA Role in Cell–Cell Communication in Cancer
    In: Cancers Vol. 14 (2022) Nr. 9, 2068
    Online Full Text: dx.doi.org/ (Open Access)
  • Jablonska, Jadwiga; Rist, Malwina; Spyra, Ilona; Tengler, Luisa; Domnich, Maksim; Kansy, Benjamin; Giebel, Bernd; Thakur, Basant Kumar; Rotter, Nicole; Lang, Stephan; Ludwig, Sonja
    Evaluation of Immunoregulatory Biomarkers on Plasma Small Extracellular Vesicles for Disease Progression and Early Therapeutic Response in Head and Neck Cancer
    In: Cells Vol. 11 (2022) Nr. 5, 902
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Hussain, Timon; Domnich, Maksim; Bordbari, Sharareh; Pylaeva, Ekaterina; Siakaeva, Elena; Spyra, Ilona; Ozel, Irem; Droege, Freya; Squire, Anthony; Lienenklaus, Stefan; Sutter, Kathrin; Hasenberg, Anja; Gunzer, Matthias; Lang, Stephan; Jablonska, Jadwiga
    IFNAR1 Deficiency Impairs Immunostimulatory Properties of Neutrophils in Tumor-Draining Lymph Nodes
    In: Frontiers in Immunology Vol. 13 (2022)
    Online Full Text: dx.doi.org/ (Open Access)
  • Jablonska, Jadwiga; Brandau, Sven
    PMN‐MDSC in newborns : Regulation of the regulators
    In: Journal of Leukocyte Biology (JLB) Vol. 112 (2022) Nr. 5, pp. 949 - 950
    Online Full Text: dx.doi.org/ (Open Access)
  • Bordbari, Sharareh; Mörchen, Britta; Pylaeva, Ekaterina; Siakaeva, Elena; Spyra, Ilona; Domnich, Maksim; Droege, Freya; Kanaan, Oliver; Lang, Karl S.; Schadendorf, Dirk; Lang, Stephan; Helfrich, Iris; Jablonska, Jadwiga
    SIRT1‐mediated deacetylation of FOXO3a transcription factor supports pro‐angiogenic activity of interferon‐deficient tumor‐associated neutrophils
    In: International Journal of Cancer Vol. 150 (2022) Nr. 7, pp. 1198 - 1211
    Online Full Text: dx.doi.org/ (Open Access)
  • Antoni, Anne-Charlotte; Pylaeva, Ekaterina; Budeus, Bettina; Jablonska, Jadwiga; Klein-Hitpaß, Ludger; Dudda, Marcel; Flohé, Stefanie B.
    TLR2-induced CD8⁺ T-cell deactivation shapes dendritic cell differentiation in the bone marrow during sepsis
    In: Frontiers in Immunology Vol. 13 (2022) 945409
    Online Full Text: dx.doi.org/ (Open Access)
  • Ozel, Irem; Duerig, Inga; Domnich, Maksim; Lang, Stephan; Pylaeva, Ekaterina; Jablonska, Jadwiga
    The Good, the Bad, and the Ugly : Neutrophils, Angiogenesis, and Cancer
    In: Cancers Vol. 14 (2022) Nr. 3, 536
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Pylaeva, Ekaterina; Ozel, Irem; Squire, Anthony; Spyra, Ilona; Wallner, Charlotte; Korek, Magdalena; Korschunow, Georg; Domnich, Maksim; Siakaeva, Elena; Goetz, Moritz; Bankfalvi, Agnes; Lang, Stephan; Kansy, Benjamin; Jablonska, Jadwiga
    B-helper neutrophils in regional lymph nodes correlate with improved prognosis in patients with head and neck cancer
    In: Cancers Vol. 13 (2021) Nr. 12, 3092
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Mülling, Kerstin; Fischer, Alexa Josephine; Siakaeva, Elena; Richter, Mathis; Bordbari, Sharareh; Spyra, Ilona; Köster, Christian; Hermann, Dirk M.; Gunzer, Matthias; Felderhoff-Müser, Ursula; Bendix, Ivo; Jablonska, Jadwiga; Herz, Josephine
    Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia-ischemia
    In: Brain, Behavior and Immunity Vol. 92 (2021) pp. 234 - 244
    Online Full Text: dx.doi.org/ (Open Access)
  • Lang, Stephan; Brandau, Sven; Marchesi, Julian Roberto; Jablonska, Jadwiga; Thurnher, Dietmar; Mattheis, Stefan; Buer, Jan; Hussain, Timon
    Das Mikrobiom bei Kopf-Hals-Tumoren – erste Erkenntnisse und Ausblick
    In: HNO Vol. 68 (2020) Nr. 12, pp. 905 - 910
    Online Full Text: dx.doi.org/
  • Ludwig, S.; Rotter, N.; Theodoraki, M.-N.; Jablonska, Jadwiga; Lammert, A.; Lang, Stephan
    Exosomen als Immunregulatoren in Kopf-Hals-Karzinomen
    In: HNO (2020)
    Online Full Text: dx.doi.org/
  • Dröge, Freya; Pylaeva, Ekaterina; Siakaeva, Elena; Bordbari, Sharareh; Spyra, Ilona; Thangavelu, Kruthika; Lueb, Carolin; Domnich, Maksim; Lang, Stephan; Geisthoff, Urban; Jablonska, Jadwiga
    Impaired Release of Neutrophil Extracellular Traps and Anemia-Associated T Cell Deficiency in Hereditary Hemorrhagic Telangiectasia
    In: Journal of Clinical Medicine (JCM) Vol. 9 (2020) Nr. 3, 767
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Jablonska, Jadwiga; Rist, M.; Lang, Stephan; Brandau, Sven
    Neutrophile Granulozyten im Tumormikromilieu – Feind oder Freund?
    In: HNO (2020)
    Online Full Text: dx.doi.org/
  • Domnich, Maksim; Riedesel, Jana; Pylaeva, Ekaterina; Kürten, Cornelius H. L.; Buer, Jan; Lang, Stephan; Jablonska, Jadwiga
    Oral Neutrophils : Underestimated Players in Oral Cancer
    In: Frontiers in Immunology Vol. 11 (2020) pp. 565683
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Jablonska, Jadwiga; Pietrowska, Monika; Ludwig, Sonja; Lang, Stephan; Thakur, Basant Kumar
    Challenges in the Isolation and Proteomic Analysis of Cancer Exosomes : Implications for Translational Research
    In: Proteomes Vol. 7 (2019) Nr. 2, 22
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Pylaeva, Ekaterina; Bordbari, Sharareh; Spyra, Ilona; Decker, Anna; Häussler, Susanne; Vybornov, Vadim; Lang, Stephan; Jablonska, Jadwiga
    Detrimental Effect of Type I IFNs During Acute Lung Infection With Pseudomonas aeruginosa Is Mediated Through the Stimulation of Neutrophil NETosis.
    In: Frontiers in Immunology Vol. 10 (2019) pp. 2190
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Umansky, Viktor; Adema, Gosse J.; Baran, Jaroslaw; Brandau, Sven; van Ginderachter, Jo; Hu, Xiaoying; Jablonska, Jadwiga; Mojsilovic, Slavko; Papadaki, Helen A.; Pico de Coaña, Yago; Santegoets, Kim C. M.; Santibanez, Juan F.; Serre, Karine; Si, Yu; Sieminska, Isabela; Velegraki, Maria; Fridlender, Zvi G.
    Interactions among myeloid regulatory cells in cancer
    In: Cancer Immunology, Immunotherapy Vol. 68 (2019) Nr. 4, pp. 645 - 660
    Online Full Text: dx.doi.org/
  • Pylaeva, Ekaterina; Harati, Mozhgan Dehghan; Spyra, Ilona; Bordbari, Sharareh; Strachan, Sarah; Thakur, Basant Kumar; Höing, Benedikt; Franklin, Cindy; Skokowa, Julia; Welte, Karl; Schadendorf, Dirk; Bankfalvi, Agnes; Brandau, Sven; Lang, Stephan; Jablonska, Jadwiga
    NAMPT signaling is critical for the proangiogenic activity of tumor-associated neutrophils
    In: International Journal of Cancer Vol. 144 (2019) Nr. 1, pp. 136 - 149
    Online Full Text: dx.doi.org/ (Open Access)
  • Siakaeva, Elena; Pylaeva, Ekaterina; Spyra, Ilona; Bordbari, Sharareh; Höing, Benedikt; Kürten, Cornelius; Lang, Stephan; Jablonska, Jadwiga
    Neutrophil maturation and survival is controlled by IFN-dependent regulation of NAMPT signaling
    In: International Journal of Molecular Sciences (IJMS) Vol. 20 (2019) Nr. 22, pp. 5584
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Decker, Anna Sophie; Pylaeva, Ekaterina; Brenzel, Alexandra; Spyra, Ilona; Dröge, Freya; Hussain, Timon; Lang, Stephan; Jablonska, Jadwiga
    Prognostic Role of Blood NETosis in the Progression of Head and Neck Cancer
    In: Cells Vol. 8 (2019) Nr. 9, pp. 946
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Pylaeva, Ekaterina; Spyra, Ilona; Bordbari, Sharareh; Lang, Stephan; Jablonska, Jadwiga
    Transfer of manipulated tumor-associated neutrophils into tumor-bearing mice to study their angiogenic potential in vivo
    In: JoVE Vol. 2019 (2019) Nr. 149, pp. e59807
    Online Full Text: dx.doi.org/
  • Jablonska, Jadwiga; Dubinska-Magiera, Magda; Jagla, Teresa; Jagla, Krzysztof; Daczewska, Malgorzata
    Drosophila Hsp67Bc hot-spot variants alter muscle structure and function
    In: Cellular and Molecular Life Sciences - CMLS Vol. 75 (2018) Nr. 23, pp. 4341 - 4356
    Online Full Text: dx.doi.org/ (Open Access)
  • Jablonska, Jadwiga; Granot, Zvi
    Neutrophil, quo vadis?
    In: Journal of Leukocyte Biology (JLB) Vol. 102 (2017) Nr. 3, pp. 685 - 688
    Online Full Text: dx.doi.org/
  • Jablonska, Jadwiga; Lang, Stephan; Sionov, Ronit Vogt; Granot, Zvi
    The regulation of pre-metastatic niche formation by neutrophils
    In: OncoTarget Vol. 8 (2017) Nr. 67, pp. 112132 - 112144
    Online Full Text: dx.doi.org/ (Open Access)
  • Bordbari, S.; Pylaeva, E.; Spyra, I.; Lang, Stephan; Jablonska-Koch, Jadwiga
    The regulatory effect of Type I IFNs on neutrophil angiogenic capability in tumor microenvironment
    In: European Journal of Immunology Vol. 47 (2017) Nr. S2, Special Issue: 47th Annual Meeting of the German Society for Immunology, 12–15 September, 2017, Erlangen, Germany, pp. 306
    Online Full Text: dx.doi.org/
  • Andzinski, Lisa; Spanier, Julia; Kasnitz, Nadine; Kröger, Andrea; Jin, Lei; Brinkmann, Melanie M.; Kalinke, Ulrich; Weiss, Siegfried; Jablonska, Jadwiga; Lienenklaus, Stefan
    Growing tumors induce a local STING dependent Type I IFN response in dendritic cells
    In: International Journal of Cancer Vol. 139 (2016) Nr. 6, pp. 1350 - 1357
    Online Full Text: dx.doi.org/
  • Nocera, David Andrés; Roselli, Emiliano; Araya, Paula; Nuñez, Nicolás Gonzalo; Lienenklaus, Stefan; Jablonska, Jadwiga; Weiss, Siegfried; Gatti, Gerardo; Brinkmann, Melanie M; Kröger, Andrea; Morón, Gabriel; Maccioni, Mariana
    In Vivo Visualizing the IFN-β Response Required for Tumor Growth Control in a Therapeutic Model of Polyadenylic-Polyuridylic Acid Administration
    In: The Journal of Immunology (JI) Vol. 196 (2016) Nr. 6, pp. 2860 - 2869
    Online Full Text: dx.doi.org/
  • Pylaeva, Ekaterina; Lang, Stephan; Jablonska, Jadwiga
    The Essential Role of Type I Interferons in Differentiation and Activation of Tumor-Associated Neutrophils
    In: Frontiers in Immunology Vol. 7 (2016) pp. 629
    Online Full Text: dx.doi.org/ (Open Access)
  • Andzinski, Lisa; Kasnitz, Nadine; Stahnke, Stephanie; Wu, Ching-Fang; Gereke, Marcus; Von Köckritz-Blickwede, Maren; Schilling, Bastian; Brandau, Sven; Weiss, Siegfried; Jablonska, Jadwiga
    Type i IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human
    In: International Journal of Cancer Vol. 138 (2016) Nr. 8, pp. 1982 - 1993
    Online Full Text: dx.doi.org/ (Open Access)
  • Andzinski, Lisa; Harati, Mozhgan Dehghan; Zyla, Edyta; Kasnitz, Nadine; Stahnke, Stephanie; Wu, Ching-Fang; Gereke, Marcus; von Kockritz-Blickwede, Maren; Schilling, Bastian; Brandau, Sven; Kanz, Lothar; Welte, Karl; Weiss, Siegfried; Skokowa, Julia; Jablonska, Jadwiga
    The Mechanism of Type I Interferon-Mediated Polarization of Tumor-Associated Neutrophils in Mice and Human
    In: Blood Vol. 126 (2015) Nr. 23,