Jadwiga Jablonska-Koch

ZMB Member
Jadwiga Jablonska-Koch

Next ZMB-Member
portrait photo of ZMB member Jadwiga Jablonska-Koch
© Koch/UKE

PD Dr. Jadwiga Jablonska-Koch

ENT Department
West German Cancer Center (WTZ)
German Cancer Research Center (DKFZ), Partnersite Essen/Düsseldorf
University Hospital Essen
45147 Essen

Research Overview

We focus on the myeloid cell/ neutrophil-dependent immunoregulatory mechanisms that are responsible for the progression of cancerogenesis and inflammation. We study the molecular mechanisms involved in neutrophil polarization, mobilization and activation, but also complex interaction between regulatory myeloid cells, such as neutrophils, monocytes/macrophages and DCs.
Moreover, we are interested in overall neutrophil biology, i.e. development, differentiation, activation, migration and responses to various inflammatory stimuli in disease. We analyze the role of multiple cytokines (with focus on type I interferons) and growth factors (e.g. G-CSF) in the regulation of emergency myelopoiesis, and neutrophil polarization and homing. Over the last years we have established and worked on the following main research themes:

  1. Neutrophil heterogeneity and immunoregulatory activity in disease
  2. Identification of intracellular factors/signaling pathways contributing to the tumorigenic transformation of neutrophils
  3. Neutrophil-mediated regulation of angiogenesis
  4. Type I interferons (IFNs) as immunomodulators
  5. Exosome-mediated suppression of immune responses in tumor
  6. The impact of tumor-mediated immunosuppression on the susceptibility to bacterial infections
Read more

Selected Publications

    Journal articles

  • Pylaeva, Ekaterina; Ozel, Irem; Squire, Anthony; Spyra, Ilona; Wallner, Charlotte; Korek, Magdalena; Korschunow, Georg; Domnich, Maksim; Siakaeva, Elena; Goetz, Moritz; Bankfalvi, Agnes; Lang, Stephan; Kansy, Benjamin; Jablonska, Jadwiga
    B-helper neutrophils in regional lymph nodes correlate with improved prognosis in patients with head and neck cancer
    In: Cancers Vol. 13 (2021) Nr. 12,
    ISSN: 2072-6694
  • Mülling, Kerstin; Fischer, Alexa Josephine; Siakaeva, Elena; Richter, Mathis; Bordbari, Sharareh; Spyra, Ilona; Köster, Christian; Hermann, Dirk M.; Gunzer, Matthias; Felderhoff-Müser, Ursula; Bendix, Ivo; Jablonska, Jadwiga; Herz, Josephine
    Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia-ischemia
    In: Brain, Behavior, and Immunity Vol. 92 (2021) pp. 234 - 244
    ISSN: 1090-2139; 0889-1591
  • Bordbari, Sharareh; Mörchen, Britta; Pylaeva, Ekaterina; Siakaeva, Elena; Spyra, Ilona; Domnich, Maksim; Droege, Freya; Kanaan, Oliver; Lang, Karl S.; Schadendorf, Dirk; Lang, Stephan; Helfrich, Iris; Jablonska, Jadwiga
    SIRT1‐mediated deacetylation of FOXO3a transcription factor supports pro‐angiogenic activity of interferon‐deficient tumor‐associated neutrophils
    In: International Journal of Cancer (2021) in press
    ISSN: 0020-7136; 1097-0215
  • Lang, Stephan; Brandau, Sven; Marchesi, Julian Roberto; Jablonska, Jadwiga; Thurnher, Dietmar; Mattheis, Stefan; Buer, Jan; Hussain, Timon
    Das Mikrobiom bei Kopf-Hals-Tumoren – erste Erkenntnisse und Ausblick
    In: HNO Vol. 68 (2020) Nr. 12, pp. 905 - 910
    ISSN: 1433-0458; 0017-6192
  • Ludwig, S.; Rotter, N.; Theodoraki, M.-N.; Jablonska, Jadwiga; Lammert, A.; Lang, Stephan
    Exosomen als Immunregulatoren in Kopf-Hals-Karzinomen
    In: HNO (2020)
    ISSN: 1433-0458; 0017-6192
  • Dröge, Freya; Pylaeva, Ekaterina; Siakaeva, Elena; Bordbari, Sharareh; Spyra, Ilona; Thangavelu, Kruthika; Lueb, Carolin; Domnich, Maksim; Lang, Stephan; Geisthoff, Urban; Jablonska, Jadwiga
    Impaired Release of Neutrophil Extracellular Traps and Anemia-Associated T Cell Deficiency in Hereditary Hemorrhagic Telangiectasia
    In: Journal of Clinical Medicine Vol. 9 (2020) Nr. 3, pp. 767
    ISSN: 2077-0383
  • Jablonska, Jadwiga; Rist, M.; Lang, Stephan; Brandau, Sven
    Neutrophile Granulozyten im Tumormikromilieu – Feind oder Freund?
    In: HNO (2020)
    ISSN: 1433-0458; 0017-6192
  • Domnich, Maksim; Riedesel, Jana; Pylaeva, Ekaterina; Kürten, Cornelius H. L.; Buer, Jan; Lang, Stephan; Jablonska, Jadwiga
    Oral Neutrophils : Underestimated Players in Oral Cancer
    In: Frontiers in Immunology Vol. 11 (2020) pp. 565683
    ISSN: 1664-3224
  • Jablonska, Jadwiga; Pietrowska, Monika; Ludwig, Sonja; Lang, Stephan; Thakur, Basant Kumar
    Challenges in the Isolation and Proteomic Analysis of Cancer Exosomes : Implications for Translational Research
    In: Proteomes Vol. 7 (2019) Nr. 2, pp. 22
    ISSN: 2227-7382
  • Pylaeva, Ekaterina; Bordbari, Sharareh; Spyra, Ilona; Decker, Anna; Häussler, Susanne; Vybornov, Vadim; Lang, Stephan; Jablonska, Jadwiga
    Detrimental Effect of Type I IFNs During Acute Lung Infection With Pseudomonas aeruginosa Is Mediated Through the Stimulation of Neutrophil NETosis.
    In: Frontiers in Immunology Vol. 10 (2019) pp. 2190
    ISSN: 1664-3224
  • Umansky, Viktor; Adema, Gosse J.; Baran, Jaroslaw; Brandau, Sven; van Ginderachter, Jo; Hu, Xiaoying; Jablonska, Jadwiga; Mojsilovic, Slavko; Papadaki, Helen A.; Pico de Coaña, Yago; Santegoets, Kim C. M.; Santibanez, Juan F.; Serre, Karine; Si, Yu; Sieminska, Isabela; Velegraki, Maria; Fridlender, Zvi G.
    Interactions among myeloid regulatory cells in cancer
    In: Cancer Immunology, Immunotherapy Vol. 68 (2019) Nr. 4, pp. 645 - 660
    ISSN: 1432-0851; 0340-7004
  • Pylaeva, Ekaterina; Harati, Mozhgan Dehghan; Spyra, Ilona; Bordbari, Sharareh; Strachan, Sarah; Thakur, Basant Kumar; Höing, Benedikt; Franklin, Cindy; Skokowa, Julia; Welte, Karl; Schadendorf, Dirk; Bankfalvi, Agnes; Brandau, Sven; Lang, Stephan; Jablonska, Jadwiga
    NAMPT signaling is critical for the proangiogenic activity of tumor-associated neutrophils
    In: International Journal of Cancer Vol. 144 (2019) Nr. 1, pp. 136 - 149
    ISSN: 0020-7136; 1097-0215
  • Siakaeva, Elena; Pylaeva, Ekaterina; Spyra, Ilona; Bordbari, Sharareh; Höing, Benedikt; Kürten, Cornelius; Lang, Stephan; Jablonska, Jadwiga
    Neutrophil maturation and survival is controlled by IFN-dependent regulation of NAMPT signaling
    In: International Journal of Molecular Sciences Vol. 20 (2019) Nr. 22, pp. 5584
    ISSN: 1422-0067; 1661-6596
  • Decker, Anna Sophie; Pylaeva, Ekaterina; Brenzel, Alexandra; Spyra, Ilona; Dröge, Freya; Hussain, Timon; Lang, Stephan; Jablonska, Jadwiga
    Prognostic Role of Blood NETosis in the Progression of Head and Neck Cancer
    In: Cells Vol. 8 (2019) Nr. 9, pp. 946
    ISSN: 2073-4409
  • Pylaeva, Ekaterina; Spyra, Ilona; Bordbari, Sharareh; Lang, Stephan; Jablonska, Jadwiga
    Transfer of manipulated tumor-associated neutrophils into tumor-bearing mice to study their angiogenic potential in vivo
    In: Journal of Visualized Experiments Vol. 2019 (2019) Nr. 149, pp. e59807
    ISSN: 1940-087X
  • Jablonska, Jadwiga; Dubinska-Magiera, Magda; Jagla, Teresa; Jagla, Krzysztof; Daczewska, Malgorzata
    Drosophila Hsp67Bc hot-spot variants alter muscle structure and function
    In: Cellular and Molecular Life Sciences - CMLS Vol. 75 (2018) Nr. 23, pp. 4341 - 4356
    ISSN: 1420-682X; 1420-9071; 0014-4754
  • Jablonska, Jadwiga; Granot, Zvi
    Neutrophil, quo vadis?
    In: Journal of Leukocyte Biology Vol. 102 (2017) Nr. 3, pp. 685 - 688
    ISSN: 1938-3673; 0741-5400
  • Jablonska, Jadwiga; Lang, Stephan; Sionov, Ronit Vogt; Granot, Zvi
    The regulation of pre-metastatic niche formation by neutrophils
    In: Oncotarget Vol. 8 (2017) Nr. 67, pp. 112132 - 112144
    ISSN: 1949-2553
  • Bordbari, S.; Pylaeva, E.; Spyra, I.; Lang, Stephan; Jablonska-Koch, Jadwiga
    The regulatory effect of Type I IFNs on neutrophil angiogenic capability in tumor microenvironment
    In: European Journal of Immunology Vol. 47 (2017) Nr. S2, Special Issue: 47th Annual Meeting of the German Society for Immunology, 12–15 September, 2017, Erlangen, Germany, pp. 306
    ISSN: 0014-2980
  • Andzinski, Lisa; Spanier, Julia; Kasnitz, Nadine; Kröger, Andrea; Jin, Lei; Brinkmann, Melanie M.; Kalinke, Ulrich; Weiss, Siegfried; Jablonska, Jadwiga; Lienenklaus, Stefan
    Growing tumors induce a local STING dependent Type I IFN response in dendritic cells
    In: International Journal of Cancer Vol. 139 (2016) Nr. 6, pp. 1350 - 1357
    ISSN: 0020-7136; 1097-0215
  • Nocera, David Andrés; Roselli, Emiliano; Araya, Paula; Nuñez, Nicolás Gonzalo; Lienenklaus, Stefan; Jablonska, Jadwiga; Weiss, Siegfried; Gatti, Gerardo; Brinkmann, Melanie M; Kröger, Andrea; Morón, Gabriel; Maccioni, Mariana
    In Vivo Visualizing the IFN-β Response Required for Tumor Growth Control in a Therapeutic Model of Polyadenylic-Polyuridylic Acid Administration
    In: The Journal of Immunology Vol. 196 (2016) Nr. 6, pp. 2860 - 2869
    ISSN: 0022-1767
  • Pylaeva, Ekaterina; Lang, Stephan; Jablonska, Jadwiga
    The Essential Role of Type I Interferons in Differentiation and Activation of Tumor-Associated Neutrophils
    In: Frontiers in Immunology Vol. 7 (2016) pp. 629
    ISSN: 1664-3224
  • Andzinski, Lisa; Kasnitz, Nadine; Stahnke, Stephanie; Wu, Ching-Fang; Gereke, Marcus; Von Köckritz-Blickwede, Maren; Schilling, Bastian; Brandau, Sven; Weiss, Siegfried; Jablonska, Jadwiga
    Type i IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human
    In: International Journal of Cancer Vol. 138 (2016) Nr. 8, pp. 1982 - 1993
    ISSN: 0020-7136; 1097-0215
  • Andzinski, Lisa; Harati, Mozhgan Dehghan; Zyla, Edyta; Kasnitz, Nadine; Stahnke, Stephanie; Wu, Ching-Fang; Gereke, Marcus; von Kockritz-Blickwede, Maren; Schilling, Bastian; Brandau, Sven; Kanz, Lothar; Welte, Karl; Weiss, Siegfried; Skokowa, Julia; Jablonska, Jadwiga
    The Mechanism of Type I Interferon-Mediated Polarization of Tumor-Associated Neutrophils in Mice and Human
    In: Blood Vol. 126 (2015) Nr. 23, -
    ISSN: 0006-4971; 1528-0020