Prof. Dr. Jadwiga Jablonska-Koch

ENT Department
West German Cancer Center (WTZ)
German Cancer Research Center (DKFZ), Partnersite Essen/Düsseldorf
University Hospital Essen
45147 Essen

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• ZMB Research Program
  Oncology

Research Overview

We focus on the myeloid cell/ neutrophil-dependent immunoregulatory mechanisms that are responsible for the progression of cancerogenesis and inflammation. We study the molecular mechanisms involved in neutrophil polarization, mobilization and activation, but also complex interaction between regulatory myeloid cells, such as neutrophils, monocytes/macrophages and DCs.
Moreover, we are interested in overall neutrophil biology, i.e. development, differentiation, activation, migration and responses to various inflammatory stimuli in disease. We analyze the role of multiple cytokines (with focus on type I interferons) and growth factors (e.g. G-CSF) in the regulation of emergency myelopoiesis, and neutrophil polarization and homing. Over the last years we have established and worked on the following main research themes:

1. Neutrophil heterogeneity and immunoregulatory activity in disease
2. Identification of intracellular factors/signaling pathways contributing to the tumorigenic transformation of neutrophils
3. Neutrophil-mediated regulation of angiogenesis
4. Type I interferons (IFNs) as immunomodulators
5. Exosome-mediated suppression of immune responses in tumor
6. The impact of tumor-mediated immunosuppression on the susceptibility to bacterial infections