ZMB Member Joachim Fandrey

ZMB Member
Joachim Fandrey

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Joachim Fandrey portrait
© J. Fandrey

Prof. Dr. Joachim Fandrey

University Hospital Essen
Virchowstr. 171
45147 Essen

Research Overview

  • Oxygen-dependent Gene Expression
    Activation of the transcription factor complex hypoxia-inducible factor-1 (HIF-1)
  • Mechanisms of Inflammatory Reactions Role of HIF-1 Complexes
    Non-hypoxic activation of hypoxia-inducible factor-1 by inflammatory cytokines and signalling molecules
    Role of reactive oxygen and nitrogen species for the function of cellular oxygen sensors
    Cross-talk of hypoxic and proinflammatory cytokine-mediated activation of genes important for angiogenesis and vascular permeability
    Pathophysiology of erythropoietin production in chronic inflammatory and malignant diseases
  • Role of HIF-1 Complexes in Muscle Trauma
    Activation of HIF-1 in traumatized tissue
    Role of HIF-1 activation for the severity of tissue trauma
    Influence of reactive oxygen and nitrogen species for regeneration processes in skeletal muscle

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Selected Publications