ZMB Member Joachim Fandrey

ZMB Member
Joachim Fandrey

Next ZMB-Member
Joachim Fandrey portrait
© J. Fandrey

Prof. Dr. Joachim Fandrey

Director of:

Institute of Physiology

University Hospital Essen
Virchowstr. 171
45147 Essen

Research Overview

  • Oxygen-dependent Gene Expression
    Activation of the transcription factor complex hypoxia-inducible factor-1 (HIF-1)
  • Mechanisms of Inflammatory Reactions Role of HIF-1 Complexes
    Non-hypoxic activation of hypoxia-inducible factor-1 by inflammatory cytokines and signalling molecules
    Role of reactive oxygen and nitrogen species for the function of cellular oxygen sensors
    Cross-talk of hypoxic and proinflammatory cytokine-mediated activation of genes important for angiogenesis and vascular permeability
    Pathophysiology of erythropoietin production in chronic inflammatory and malignant diseases
  • Role of HIF-1 Complexes in Muscle Trauma
    Activation of HIF-1 in traumatized tissue
    Role of HIF-1 activation for the severity of tissue trauma
    Influence of reactive oxygen and nitrogen species for regeneration processes in skeletal muscle

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Selected Publications

    Journal articles

  • Schneider, Pascal; Fandrey, Joachim; Leu, Tristan
    Primary cilia as antennas for oxygen
    In: American Journal of Physiology: Cell Physiology, Vol. 328, 2025, Nr. 2, pp. C381 – C386
    DOI
  • Schönberger, Tina; Jakobs, Marie; Friedel, Anna-Lena; Hörbelt-Grünheidt, Tina; Tebbe, Bastian; Witzke, Oliver; Schedlowski, Manfred; Fandrey, Joachim
    Exposure to normobaric hypoxia shapes the acute inflammatory response in human whole blood cells in vivo
    In: Pflügers Archiv: European Journal of Physiology, Vol. 476, 2024, Nr. 9, Special Issue: Oxygen Sensors – HIF-Hydroxylases in Physiology, Pathophysiology and Pharmacology, pp. 1369 – 1381
    DOI (Open Access)
  • Aboouf, Mostafa A.; Armbruster, Julia; Guscetti, Franco; Thiersch, Markus; Boss, Andreas; Gödecke, Axel; Winning, Sandra; Padberg, Claudia; Fandrey, Joachim; Kristiansen, Glen; Bicker, Anne; Hankeln, Thomas; Gassmann, Max; Gorr, Thomas A.
    Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice
    In: Scientific Reports, Vol. 13, 2023, Nr. 1, 7530
    DOI (Open Access)
  • Wrobeln, Anna; Leu, Tristan; Jablonska, Jadwiga; Geisthoff, Urban; Lang, Stephan; Fandrey, Joachim; Droege, Freya
    Altered hypoxia inducible factor regulation in hereditary haemorrhagic telangiectasia
    In: Scientific Reports, Vol. 12, 2022, Nr. 1, 5877
    DOI, Online Full Text (Open Access)
  • Leu, Tristan; Fandrey, Joachim; Schreiber, Timm
    (H)IF applicable: promotion of neurogenesis by induced HIF-2 signalling after ischaemia
    In: Pflügers Archiv: European Journal of Physiology, Vol. 473, 2021, Nr. 8, pp. 1287 – 1299
    DOI (Open Access)
  • Sobecki, Michal; Krzywinska, Ewelina; Nagarajan, Shunmugam; Audigé, Annette; Huỳnh, Khanh; Zacharjasz, Julian; Debbache, Julien; Kerdiles, Yann; Gotthardt, Dagmar; Takeda, Norihiko; Fandrey, Joachim; Sommer, Lukas; Sexl, Veronika; Stockmann, Christian
    NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence
    In: Nature Communications, Vol. 12, 2021, Nr. 1, 4700
    DOI (Open Access)
  • Wrobeln, Anna; Jägers, Johannes; Quinting, Theresa; Schreiber, Timm; Kirsch, Michael; Fandrey, Joachim; Ferenz, Katja
    Albumin-derived perfluorocarbon-based artificial oxygen carriers can avoid hypoxic tissue damage in massive hemodilution
    In: Scientific Reports, Vol. 10, 2020, Nr. 1, pp. 11950
    DOI, Online Full Text (Open Access)
  • Bernardini, André; Wolf, Alexandra; Brockmeier, Ulf; Riffkin, Helena; Metzen, Eric; Acker-Palmer, Amparo; Fandrey, Joachim; Acker, Helmut
    Carotid body type I cells engage flavoprotein and Pin1 for oxygen sensing
    In: American Journal of Physiology: Cell Physiology, Vol. 318, 2020, Nr. 4, pp. C719 – C731
    DOI (Open Access)
  • Kleszka, Kira; Leu, Tristan; Quinting, Theresa; Jastrow, Holger; Pechlivanis, Sonali; Fandrey, Joachim; Schreiber, Timm
    Hypoxia-inducible factor-2α is crucial for proper brain development
    In: Scientific Reports, Vol. 10, 2020, Nr. 1, 19146
    DOI, Online Full Text (Open Access)
  • Settelmeier, Stephan; Schreiber, Timm; Mäki, Joni; Byts, Nadiya; Koivunen, Peppi; Myllyharju, Johanna; Fandrey, Joachim; Winning, Sandra
    Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice
    In: PLoS ONE, Vol. 15, 2020, Nr. 5, pp. e0233261
    DOI (Open Access)
  • Korencak, Marek; Byrne, Morgan; Richter, Enrico; Schultz, Bruce T.; Juszczak, Patrick; Ake, Julie A.; Ganesan, Anuradha; Okulicz, Jason F.; Robb, Merlin L.; De Los Reyes, Buena; Winning, Sandra; Fandrey, Joachim; Burgess, Timothy H.; Esser, Stefan; Michael, Nelson L.; Agan, Brian K.; Streeck, Hendrik
    Effect of HIV infection and antiretroviral therapy on immune cellular functions
    In: JCI Insight, Vol. 4, 2019, Nr. 12, :e126675
    DOI (Open Access)
  • Fandrey, Joachim; Schödel, Johannes; Eckardt, Kai-Uwe; Katschinski, Dörthe M.; Wenger, Roland H.
    Now a Nobel gas : oxygen
    In: Pflügers Archiv: European Journal of Physiology, Vol. 471, 2019, Nr. 11/12, pp. 1343 – 1358
    DOI
  • Schreiber, Timm; Quinting, Theresa; Dittmer, Ulf; Fandrey, Joachim; Sutter, Kathrin
    Hypoxia-inducible factor 1α is essential for macrophage-mediated erythroblast proliferation in acute friend retrovirus infection
    In: Scientific Reports, Vol. 7, 2017, art. no. 17236
    DOI (Open Access)
  • Bäcker, Veronika; Cheung, Fung-Yi; Siveke, Jens T.; Fandrey, Joachim; Winning, Sandra
    Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis
    In: PLoS ONE, Vol. 12, 2017, Nr. 12, e0190074
    DOI (Open Access)
  • Krzywinska, Ewelina; Kantari-Mimoun, Chahrazade; Kerdiles, Yann; Sobecki, Michal; Isagawa, Takayuki; Gotthardt, Dagmar; Castells, Magali; Haubold, Johannes; Millien, Corinne; Viel, Thomas; Tavitian, Bertrand; Takeda, Norihiko; Fandrey, Joachim; Vivier, Eric; Sexl, Veronika; Stockmann, Christian
    Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.
    In: Nature Communications, Vol. 8, 2017, pp. 1597
    DOI (Open Access)
  • Flück, Katharina; Fandrey, Joachim
    Oxygen sensing in intestinal mucosal inflammation
    In: Pflügers Archiv: European Journal of Physiology, Vol. 468, 2016, Nr. 1, pp. 77 – 84
    DOI
  • Klose, Ralph; Krzywinska, Ewelina; Castells, Magali; Gotthardt, Dagmar; Putz, Eva Maria; Kantari-Mimoun, Chahrazade; Chikdene, Naima; Meinecke, Anna-Katharina; Schrödter, Katrin; Helfrich, Iris; Fandrey, Joachim; Sexl, Veronika; Stockmann, Christian
    Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia
    In: Nature Communications, Vol. 7, 2016, pp. 12528
    DOI (Open Access)
  • Hülsemann, M. F.; Patz, Michaela; Beckmann, L.; Brinkmann, K.; Otto, Teresa; Fandrey, Joachim; Becker, Hans Jiro; Theurich, Sebastian; Von Bergwelt-Baildon, Michael S.; Pallasch, Christian Philipp; Zahedi, P.; Kashkar, Hamid; Reinhardt, Hans Christian; Hallek, Michael J.; Wendtner, Clemens Martin; Frenzel, Lukas P.
    Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia
    In: Leukemia, Vol. 29, 2015, Nr. 4, pp. 981 – 984
    DOI
  • Maxwell, Perry; Melendez-Rodríguez, Florinda; Matchett, Kyle B.; Aragones, Julian; Ben-Califa, Nathalie; Jaekel, Heidelinde; Hengst, Ludger; Lindner, Herbert; Bernardini, Andre; Brockmeier, Ulf; Fandrey, Joachim; Grunert, Fritz; Oster, Howard S.; Mittelman, Moshe; El-Tanani, Mohamed; Thiersch, Markus; Schneider Gasser, Edith M.; Gassmann, Max; Dangoor, David; Cuthbert, Robert J.; Irvine, Alexandra; Jordan, Anne; Lappin, Terence; Thompson, John; Neumann, Drorit
    Novel antibodies directed against the human erythropoietin receptor : Creating a basis for clinical implementation
    In: British Journal of Haematology, Vol. 168, 2015, Nr. 3, pp. 429 – 442
    DOI
  • Kantari-Mimoun, Chahrazade; Castells, Magali; Klose, Ralph; Meinecke, Anna-Katharina; Lemberger, Ursula J.; Rautou, Pierre-Emmanuel; Pinot-Roussel, Helene; Badoual, Cecile; Schrödter, Katrin; Österreicher, Christoph H.; Fandrey, Joachim; Stockmann, Christian
    Resolution of liver fibrosis requires myeloid cell-driven sinusoidal angiogenesis
    In: Hepatology, Vol. 61, 2015, Nr. 6, pp. 2042 – 2055
    DOI (Open Access)
  • Funk, Kristina; Scheerer, Nina; Verhaegh, Rabea; Pütter, Carolin; Fandrey, Joachim; de Groot, Herbert
    Severe Blunt Muscle Trauma in Rats : Only Marginal Hypoxia in the Injured Area
    In: PLoS ONE, Vol. 9, 2014, Nr. 10, pp. e111151
    DOI (Open Access)
  • Franke, Kristin; Kalucka, Joanna; Mamlouk, Soulafa; Singh, Rashim Pal; Muschter, Antje; Weidemann, Alexander; Iyengar, Vasuprada; Jahn, Steffen; Wieczorek, Kathrin; Geiger, Kathrin; Muders, Michael; Sykes, Alex M.; Poitz, David M.; Ripich, Tatsiana; Otto, Teresa; Bergmann, Sybille; Breier, Georg; Baretton, Gustavo; Fong, Guo-Hua; Greaves, David R.; Bornstein, Stefan; Chavakis, Triantafyllos; Fandrey, Joachim; Gassmann, Max; Wielockx, Ben
    HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis
    In: Blood, Vol. 121, 2013, Nr. 8, pp. 1436 – 1445
    DOI
  • Meinecke, Anna-Katharina; Nagy, Nadine; D'Amico Lago, Gabriela; Kirmse, Santina; Klose, Ralph; Schrödter, Katrin; Zimmermann, Annika; Helfrich, Iris; Rundqvist, Helene; Theegarten, Dirk; Anhenn, Olaf; Orian-Rousseau, Véronique; Johnson, Randall S.; Alitalo, Kari; Fischer, Jens W.; Fandrey, Joachim; Stockmann, Christian
    Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis
    In: Blood, Vol. 119, 2012, Nr. 24, pp. 5931 – 5942
    DOI
  • Wollenick, Kristin; Hu, Jun; Kristiansen, Glen; Schraml, Peter; Rehrauer, Hubert; Berchner-Pfannschmidt, Utta; Fandrey, Joachim; Wenger, Roland H.; Stiehl, Daniel P.
    Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling
    In: Nucleic Acids Research, Vol. 40, 2012, Nr. 5, pp. 1928 – 1943
    DOI (Open Access)
  • Fandrey, Joachim
    Why not the liver instead of the kidney?
    In: Blood, Vol. 120, 2012, Nr. 9, pp. 1760 – 1761
    DOI (Open Access)
  • Wotzlaw, Christoph; Bernardini, André; Berchner-Pfannschmidt, Utta; Papkovsky, Dmitri; Acker, Helmut; Fandrey, Joachim
    Multifocal animated imaging of changes in cellular oxygen and calcium concentrations and membrane potential within the intact adult mouse carotid body ex vivo
    In: American Journal of Physiology: Cell Physiology, Vol. 301, 2011, Nr. 2, pp. C266 – 71
    DOI
  • Frede, Stilla; Freitag, Patricia; Geuting, Luise; Konietzny, Rebecca; Fandrey, Joachim
    Oxygen-regulated expression of the erythropoietin gene in the human renal cell line REPC
    In: Blood, Vol. 117, 2011, Nr. 18, pp. 4905 – 4914
    DOI (Open Access)
  • Brockmeier, Ulf; Platzek, Corinna; Schneider, Kirsten; Patak, Pauline; Bernardini, André; Fandrey, Joachim; Metzen, Eric
    The Function of Hypoxia-Inducible Factor (HIF) Is Independent of the Endoplasmic Reticulum Protein OS-9
    In: PLoS ONE, Vol. 6, 2011, Nr. 4, pp. e19151
    DOI, Online Full Text (Open Access)
  • Dürig, Jan; Nückel, Holger; Cremer, M.; Führer, A.; Halfmeyer, K.; Fandrey, Joachim; Möröy, Tarik; Klein-Hitpaß, Ludger; Dührsen, Ulrich
    ZAP-70 expression is a prognostic factor in chronic lymphocytic leukemia
    In: Leukemia, Vol. 17, 2003, Nr. 12, pp. 2426 – 2434
    DOI
  • Stolze, I.; Berchner-Pfannschmidt, Utta; Freitag, P.; Wotzlaw, C.; Rössler, J.; Frede, Stilla; Acker, H.; Fandrey, Joachim
    Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells
    In: Blood, Vol. 100, 2002, Nr. 7, pp. 2623 – 2628
    DOI
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