ZMB Member Joachim Fandrey

ZMB Member
Joachim Fandrey

Next ZMB-Member
Joachim Fandrey portrait
© J. Fandrey

Prof. Dr. Joachim Fandrey

University Hospital Essen
Virchowstr. 171
45147 Essen

Research Overview

  • Oxygen-dependent Gene Expression
    Activation of the transcription factor complex hypoxia-inducible factor-1 (HIF-1)
  • Mechanisms of Inflammatory Reactions Role of HIF-1 Complexes
    Non-hypoxic activation of hypoxia-inducible factor-1 by inflammatory cytokines and signalling molecules
    Role of reactive oxygen and nitrogen species for the function of cellular oxygen sensors
    Cross-talk of hypoxic and proinflammatory cytokine-mediated activation of genes important for angiogenesis and vascular permeability
    Pathophysiology of erythropoietin production in chronic inflammatory and malignant diseases
  • Role of HIF-1 Complexes in Muscle Trauma
    Activation of HIF-1 in traumatized tissue
    Role of HIF-1 activation for the severity of tissue trauma
    Influence of reactive oxygen and nitrogen species for regeneration processes in skeletal muscle

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Selected Publications

    Journal articles

  • Wrobeln, Anna; Jägers, Johannes; Quinting, Theresa; Schreiber, Timm; Kirsch, Michael; Fandrey, Joachim; Ferenz, Katja
    Albumin-derived perfluorocarbon-based artificial oxygen carriers can avoid hypoxic tissue damage in massive hemodilution
    In: Scientific Reports Vol. 10 (2020) Nr. 1, pp. 11950
    ISSN: 2045-2322
  • Bernardini, André; Wolf, Alexandra; Brockmeier, Ulf; Riffkin, Helena; Metzen, Eric; Acker-Palmer, Amparo; Fandrey, Joachim; Acker, Helmut
    Carotid body type I cells engage flavoprotein and Pin1 for oxygen sensing
    In: American Journal of Physiology: Cell Physiology Vol. 318 (2020) Nr. 4, pp. C719 - C731
    ISSN: 1522-1563; 0002-9513; 0363-6143
  • Kleszka, Kira; Leu, Tristan; Quinting, Theresa; Jastrow, Holger; Pechlivanis, Sonali; Fandrey, Joachim; Schreiber, Timm
    Hypoxia-inducible factor-2α is crucial for proper brain development
    In: Scientific Reports Vol. 10 (2020) Nr. 1, pp. 19146
    ISSN: 2045-2322
  • Settelmeier, Stephan; Schreiber, Timm; Mäki, Joni; Byts, Nadiya; Koivunen, Peppi; Myllyharju, Johanna; Fandrey, Joachim; Winning, Sandra
    Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice
    In: PLoS ONE Vol. 15 (2020) Nr. 5, pp. e0233261
    ISSN: 1932-6203
  • Korencak, Marek; Byrne, Morgan; Richter, Enrico; Schultz, Bruce T.; Juszczak, Patrick; Ake, Julie A.; Ganesan, Anuradha; Okulicz, Jason F.; Robb, Merlin L.; De Los Reyes, Buena; Winning, Sandra; Fandrey, Joachim; Burgess, Timothy H.; Esser, Stefan; Michael, Nelson L.; Agan, Brian K.; Streeck, Hendrik
    Effect of HIV infection and antiretroviral therapy on immune cellular functions
    In: JCI Insight Vol. 4 (2019) Nr. 12,
    ISSN: 2379-3708
  • Fandrey, Joachim; Schödel, Johannes; Eckardt, Kai-Uwe; Katschinski, Dörthe M.; Wenger, Roland H.
    Now a Nobel gas : oxygen
    In: Pflügers Archiv: European Journal of Physiology Vol. 471 (2019) Nr. 11/12, pp. 1343 - 1358
    ISSN: 1432-2013; 0031-6768
  • Schreiber, Timm; Quinting, Theresa; Dittmer, Ulf; Fandrey, Joachim; Sutter, Kathrin
    Hypoxia-inducible factor 1α is essential for macrophage-mediated erythroblast proliferation in acute friend retrovirus infection
    In: Scientific Reports Vol. 7 (2017) art. no. 17236
    ISSN: 2045-2322
  • Bäcker, Veronika; Cheung, Fung-Yi; Siveke, Jens; Fandrey, Joachim; Winning, Sandra
    Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis
    In: PLoS ONE Vol. 12 (2017) Nr. 12, pp. e0190074
    ISSN: 1932-6203
  • Krzywinska, Ewelina; Kantari-Mimoun, Chahrazade; Kerdiles, Yann; Sobecki, Michal; Isagawa, Takayuki; Gotthardt, Dagmar; Castells, Magali; Haubold, Johannes; Millien, Corinne; Viel, Thomas; Tavitian, Bertrand; Takeda, Norihiko; Fandrey, Joachim; Vivier, Eric; Sexl, Veronika; Stockmann, Christian
    Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.
    In: Nature Communications Vol. 8 (2017) pp. 1597
    ISSN: 2041-1723
  • Flück, Katharina; Fandrey, Joachim
    Oxygen sensing in intestinal mucosal inflammation
    In: Pflügers Archiv: European Journal of Physiology Vol. 468 (2016) Nr. 1, pp. 77 - 84
    ISSN: 1432-2013; 0031-6768
  • Klose, Ralph; Krzywinska, Ewelina; Castells, Magali; Gotthardt, Dagmar; Putz, Eva Maria; Kantari-Mimoun, Chahrazade; Chikdene, Naima; Meinecke, Anna-Katharina; Schrödter, Katrin; Helfrich, Iris; Fandrey, Joachim; Sexl, Veronika; Stockmann, Christian
    Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia
    In: Nature Communications Vol. 7 (2016) pp. 12528
    ISSN: 2041-1723
  • Hülsemann, M. F.; Patz, Michaela; Beckmann, L.; Brinkmann, K.; Otto, Teresa; Fandrey, Joachim; Becker, Hans Jiro; Theurich, Sebastian; Von Bergwelt-Baildon, Michael S.; Pallasch, Christian Philipp; Zahedi, P.; Kashkar, Hamid; Reinhardt, Hans Christian; Hallek, Michael J.; Wendtner, Clemens Martin; Frenzel, Lukas P.
    Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia
    In: Leukemia Vol. 29 (2015) Nr. 4, pp. 981 - 984
    ISSN: 0887-6924
  • Maxwell, Perry; Melendez-Rodríguez, Florinda; Matchett, Kyle B.; Aragones, Julian; Ben-Califa, Nathalie; Jaekel, Heidelinde; Hengst, Ludger; Lindner, Herbert; Bernardini, Andre; Brockmeier, Ulf; Fandrey, Joachim; Grunert, Fritz; Oster, Howard S.; Mittelman, Moshe; El-Tanani, Mohamed; Thiersch, Markus; Schneider Gasser, Edith M.; Gassmann, Max; Dangoor, David; Cuthbert, Robert J.; Irvine, Alexandra; Jordan, Anne; Lappin, Terence; Thompson, John; Neumann, Drorit
    Novel antibodies directed against the human erythropoietin receptor : Creating a basis for clinical implementation
    In: British Journal of Haematology Vol. 168 (2015) Nr. 3, pp. 429 - 442
    ISSN: 0007-1048
  • Kantari-Mimoun, Chahrazade; Castells, Magali; Klose, Ralph; Meinecke, Anna-Katharina; Lemberger, Ursula J.; Rautou, Pierre-Emmanuel; Pinot-Roussel, Helene; Badoual, Cecile; Schrödter, Katrin; Österreicher, Christoph H.; Fandrey, Joachim; Stockmann, Christian
    Resolution of liver fibrosis requires myeloid cell-driven sinusoidal angiogenesis
    In: Hepatology Vol. 61 (2015) Nr. 6, pp. 2042 - 2055
    ISSN: 0270-9139; 1527-3350
  • Funk, Kristina; Scheerer, Nina; Verhaegh, Rabea; Pütter, Carolin; Fandrey, Joachim; de Groot, Herbert
    Severe Blunt Muscle Trauma in Rats : Only Marginal Hypoxia in the Injured Area
    In: PLoS ONE Vol. 9 (2014) Nr. 10, pp. e111151
    ISSN: 1932-6203
  • Franke, Kristin; Kalucka, Joanna; Mamlouk, Soulafa; Singh, Rashim Pal; Muschter, Antje; Weidemann, Alexander; Iyengar, Vasuprada; Jahn, Steffen; Wieczorek, Kathrin; Geiger, Kathrin; Muders, Michael; Sykes, Alex M.; Poitz, David M.; Ripich, Tatsiana; Otto, Teresa; Bergmann, Sybille; Breier, Georg; Baretton, Gustavo; Fong, Guo-Hua; Greaves, David R.; Bornstein, Stefan; Chavakis, Triantafyllos; Fandrey, Joachim; Gassmann, Max; Wielockx, Ben
    HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis
    In: Blood Vol. 121 (2013) Nr. 8, pp. 1436 - 1445
    ISSN: 1528-0020; 0006-4971
  • Meinecke, Anna-Katharina; Nagy, Nadine; D'Amico Lago, Gabriela; Kirmse, Santina; Klose, Ralph; Schrödter, Katrin; Zimmermann, Annika; Helfrich, Iris; Rundqvist, Helene; Theegarten, Dirk; Anhenn, Olaf; Orian-Rousseau, Véronique; Johnson, Randall S.; Alitalo, Kari; Fischer, Jens W.; Fandrey, Joachim; Stockmann, Christian
    Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis
    In: Blood Vol. 119 (2012) Nr. 24, pp. 5931 - 5942
    ISSN: 1528-0020; 0006-4971
  • Wollenick, Kristin; Hu, Jun; Kristiansen, Glen; Schraml, Peter; Rehrauer, Hubert; Berchner-Pfannschmidt, Utta; Fandrey, Joachim; Wenger, Roland H.; Stiehl, Daniel P.
    Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling
    In: Nucleic Acids Research Vol. 40 (2012) Nr. 5, pp. 1928 - 1943
    ISSN: 1362-4962; 0301-5610; 0305-1048
  • Fandrey, Joachim
    Why not the liver instead of the kidney?
    In: Blood Vol. 120 (2012) Nr. 9, pp. 1760 - 1761
    ISSN: 0006-4971
  • Wotzlaw, Christoph; Bernardini, André; Berchner-Pfannschmidt, Utta; Papkovsky, Dmitri; Acker, Helmut; Fandrey, Joachim
    Multifocal animated imaging of changes in cellular oxygen and calcium concentrations and membrane potential within the intact adult mouse carotid body ex vivo
    In: American Journal of Physiology: Cell Physiology Vol. 301 (2011) Nr. 2, pp. C266 - 71
    ISSN: 1522-1563; 0002-9513; 0363-6143
  • Brockmeier, Ulf; Platzek, Corinna; Schneider, Kirsten; Patak, Pauline; Bernardini, André; Fandrey, Joachim; Metzen, Eric
    The Function of Hypoxia-Inducible Factor (HIF) Is Independent of the Endoplasmic Reticulum Protein OS-9
    In: PLoS ONE Vol. 6 (2011) Nr. 4, pp. e19151
    ISSN: 1932-6203
  • Wotzlaw, Christoph; Fandrey, Joachim
    Monitoring of cellular responses to hypoxia
    In: Methods in Molecular Biology Vol. 591 (2010) pp. 243 - 255
    ISSN: 1064-3745
  • Dürig, Jan; Nückel, Holger; Cremer, M.; Führer, A.; Halfmeyer, K.; Fandrey, Joachim; Möröy, Tarik; Klein-Hitpaß, Ludger; Dührsen, Ulrich
    ZAP-70 expression is a prognostic factor in chronic lymphocytic leukemia
    In: Leukemia Vol. 17 (2003) Nr. 12, pp. 2426 - 2434
    ISSN: 0887-6924; 1476-5551
  • Stolze, I.; Berchner-Pfannschmidt, Utta; Freitag, P.; Wotzlaw, C.; Rössler, J.; Frede, Stilla; Acker, H.; Fandrey, Joachim
    Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells
    In: Blood Vol. 100 (2002) Nr. 7, pp. 2623 - 2628
    ISSN: 0006-4971; 1528-0020