Research Objective Group Professor Fandrey
- Oxygen-dependent Gene Expression
Activation of the transcription factor complex hypoxia-inducible factor-1 (HIF-1)
- Mechanisms of Inflammatory Reactions Role of HIF-1 Complexes
Non-hypoxic activation of hypoxia-inducible factor-1 by inflammatory cytokines and signalling molecules | Role of reactive oxygen and nitrogen species for the function of cellular oxygen sensors | Cross-talk of hypoxic and proinflammatory cytokine-mediated activation of genes important for angiogenesis and vascular permeability | Pathophysiology of erythropoietin production in chronic inflammatory and malignant diseases Dr. Sandra Winning | Dr. Teresa Otto.
- Role of HIF-1 Complexes in Muscle Trauma
Activation of HIF-1 in traumatized tissue | Role of HIF-1 activation for the severity of tissue trauma | Influence of reactive oxygen and nitrogen species for regeneration processes in skeletal muscle.