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1.

Hussmann M, Janke K, Kranz P, Neumann F, Mersch E, Baumann M, Goepelt K, Brockmeier U, Metzen E. Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics. Oncotarget. 2015 Nov 17;6(36):39247-61.

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2.

Janke K, Brockmeier U, Kuhlmann K, Eisenacher M, Nolde J, Meyer HE, Mairbäurl H, Metzen E. - Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2). - J Cell Sci. 2013 Jun 15;126(12):2629-40.

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3.

Jin F, Brockmeier U, Otterbach F, Metzen E. - New insight into the SDF-1/CXCR4 axis in a breast carcinoma model: hypoxia-induced endothelial SDF-1 and tumor cell CXCR4 are required for tumor cell intravasation. - Mol Cancer Res. 2012 Aug;10(8):1021-31.

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4.

Ströfer M, Jelkmann W, Metzen E, Brockmeier U, Dunst J, Depping R. - Stabilisation and Knockdown of HIF - Two Distinct Ways Comparably Important in Radiotherapy. - Cell Physiol Biochem. 2011;28(5):805-12. Epub 2011 Dec 15.

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5.

Brockmeier U, Platzek C, Schneider K, Patak P, Bernardini A, Fandrey J, Metzen E. - The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. - PLoS One. 2011 Apr 29;6(4):e19151.

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6.

Rantanen K, Pursiheimo J, Högel H, Himanen V, Metzen E, Jaakkola PM - Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation - Mol Biol Cell. 2008 May;19(5):2231-40.

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7.

Metzen E - PHDs in adult life: not simple, not redundant - Blood, Mar 2008; 111: 2947 - 2948.

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8.

Laugsch M, Metzen E, Svensson T, Depping R, Jelkmann W. - Lack of functional erythropoietin receptors of cancer cell lines. - Int J Cancer, 2008 Mar 1;122(5):1005-11

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9.

Bruegge K, Jelkmann W, Metzen E - Hydroxylation of Hypoxia-inducible Transcription Factors and Chemical Compounds Targeting the HIF-α Hydroxylases - Curr Med Chem 2007 Jul; 14(17): 1853 – 1862

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10.

Wotzlaw C, Otto T, Berchner-Pfannschmidt U, Metzen E, Acker H, Fandrey J - Optical analysis of the HIF-1 complex in living cells by FRET and FRAP - FASEB J, 2007 Mar; 21(3):700-7

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11.

Doege K, Heine S, Jensen I, Jelkmann W, Metzen E. - Inhibition of mitochondrial respiration elevates oxygen concentration, but leaves regulation of hypoxia-inducible factor (HIF) intact - Blood, 2005 Oct 01; 106(7): 2311-2317

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12.

Metzen E, Stiehl DP, Doege K, Marxsen JH, Hellwig-Bürgel T, Jelkmann W. - Regulation of the Prolyl Hydroxylase Domain Protein 2 (phd2/egln-1) gene: Identification of a functional hypoxia-responsive element - Biochem J 2005 May 01; 387 (Pt 3): 711-717.

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13.

Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E. - Hypoxia-Inducible Factor-1 Promotes its Degradation by Induction of HIF-α - Prolyl-4-Hydroxylases - Biochem J. 2004 Aug 1; 381(Pt 3): 761-767.

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14.

Metzen E, Ratcliffe PJ. - HIF Hydroxylation and Cellular Oxygen Sensing. - Biol Chem. 2004 Mar-Apr; 385(3-4): 223-230.

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15.

Metzen E, Zhou J, Jelkmann W, Fandrey J, Brüne B. - Nitric oxide impairs normoxic degradation of HIF-1α by inhibition of prolyl hydroxylases. - Mol Biol Cell. 2003 Aug; 14(8): 3470-3481.

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16.

Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-Burgel T, Jelkmann W, Acker H, Fandrey J. - Intracellular localisation of human HIF-1α hydroxylases: implications for oxygen sensing. - J Cell Sci. 2003 Apr 1; 116(Pt 7): 1319-1326.

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17.

Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. - C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. - Cell. 2001 Oct 5; 107(1): 43-54.

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