Welcome to ZMB
Welcome to ZMB
The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.
News & Events

Medbio Alumnus Congratulations Dr. Tim Nierhaus
We cordially congratulate Tim Nierhaus, an alumnus of our degree program „Medical Biology“. Tim successfully completed his doctorate at Cambridge University under the supervision of Jan Löwe, research leader at the MRC Laboratory of Molecular Biology (LMB).
Nierhaus, T. (2020). The bacterial actin-like cell division protein FtsA forms antiparallel double filaments upon binding of FtsN.
Thesis
Paper

Neu an der UDE/am UK Essen: Sebastian Bauer Personalisierte Krebs-Therapie
[13.10.2021] Krebskranke mit einer Tablette ohne große Nebenwirkungen behandeln – ein onkologischer Traum. „Als ich mit der Tumorforschung begann, habe ich dieses – leider noch zu seltene – medizinische Wunder erlebt“, sagt Dr. Sebastian Bauer. Der neue Professor für Translationale Onkologie erforscht an der UDE-Fakultät für Medizin unter anderem personalisierte Tumortherapien. Er ist zugleich ärztlicher Leiter des Sarkomzentrums des UK Essen.

Save the date Auf zu neuen Kooperationen
Seminar zum Austausch der Disziplinen
***
NEUE TERMINE
22.06.2022
21.09.2022
14.12.2022
von 14:30 – 16 Uhr
***
Interessierte SprecherInnen können sich gerne bei Dr. Maike Müller melden.

KFO 337 "PhenoTImE" International Symposium
„Phenotypic Therapy and Immune Escape in Cancer“
4th March 2022
Press Releases 2021/2022

Neue Methoden für verschiedene Disziplinen Wissenschaftsrat empfiehlt Forschungsbau zu Katalyse
[29.04.2022] Meilenstein für die Grundlagenforschung an der UDE: Der Wissenschaftsrat hat den geplanten Forschungsbau ACTIVE SITES als förderungswürdig eingestuft. Das Vorhaben wird damit – vorbehaltlich der abschließenden Entscheidung der Gemeinsamen Wissenschaftskonferenz (GWK) – realisiert. Die Kosten für Bau und Ausstattung von 69 Millionen Euro übernehmen jeweils zur Hälfte der Bund und das Land Nordrhein-Westfalen. Die UDE erhält mit ACTIVE SITES ein Zentrum von internationaler Strahlkraft, an dem sogenannte aktive Zentren erforscht werden.

Folgeförderung für Krebsforschung Überlebensstrategie gefährlicher Tumore entschlüsselt
[06.04.2022] Wie schaffen es einige Tumore, sich gegen etablierte Krebstherapien und Medikamente erfolgreich zu wehren? Forschende der Medizinischen Fakultät der UDE verstehen das immer besser. Seit 2018 beschäftigen sie sich damit im Krebsforschungsverbund PhenoTImE, den die Deutsche Forschungsgemeinschaft (DFG) fördert. Dank vielversprechender Ergebnisse hat die DFG die Förderung jetzt um drei Jahre verlängert und stattet den Verbund mit weiteren knapp vier Millionen Euro aus.

NRW fördert Netzwerke CANTAR (CANcer TARgeting) - Netzwerk zwischen Forschenden aus Chemie, Biologie und Medizin
[01.04.2022] Mit über 81 Millionen Euro fördert die NRW-Landesregierung ab August fünf herausragende Forschungsnetzwerke, um sie nachhaltig zu stärken. Es geht um die zukunftweisenden Themen Hirnforschung, Künstliche Intelligenz, Informationstechnik, Krebsbekämpfung und Teilchenphysik. An zwei der geförderten Verbünde ist die UDE beteiligt: terahertz.NRW sowie CANTAR erhalten in den kommenden vier Jahren bis zu 19,4 Millionen Euro, damit sie ihre Ideen weiterentwickeln können.

HNO-Krebs verstehen Blick ins Mikromilieu von Kopf-Hals-Tumoren
[07.02.2022] Krebs der Schleimhäute im HNO-Bereich, also in Mundhöhle, Rachen oder Kehlkopf ist die sechsthäufigste Tumorerkrankung. Wissenschaftler:innen der Medizinischen Fakultät der UDE haben nun mithilfe einer neuen Technik HNO-Plattenepithelkarzinome untersucht, um das Milieu im Tumor besser zu verstehen. Sie möchten so Ursachen für die Krebsentstehung klären und bessere Früherkennungs- und Behandlungsmethoden entwickeln. Ihre Erkenntnisse sind in „Nature Communications“ veröffentlicht.

Neue Emmy Noether-Gruppe Therapien für Hautkrebs verbessern
[12.01.2022] Die Deutsche Forschungsgemeinschaft (DFG) hat Prof. Dr. Dr. Alpaslan Tasdogan von der Medizinischen Fakultät der UDE in ihr renommiertes Emmy Noether-Programm aufgenommen. Damit fördert sie auch sein neues Krebsforschungsprojekt mit 1,9 Millionen Euro für die kommenden sechs Jahre. Tasdogan und sein Team suchen nach neuen Therapien, mit denen die Ausbreitung des Schwarzen Hautkrebses (Malignes Melanom) besser verhindert werden kann.

Breakdown of 3D Protein Structures Threaded as an Eyelet
[29.11.2021] It’s an old needlework trick, and a protein in our body knows it: Instead of threading yarn into the eye from the end, it can be easier to pass a loop through it. This is how a protein in our body works, unfolding or separating other protein structures. UDE's Biologists have made this discovery and published it in Nature Structural & Molecular Biology.

Über 15 Mio. Euro für Tumorforschung Resistente Krebszellen besser bekämpfen
[22.11.2021] Im Laufe einer Krebserkrankung verändern sich Tumorzellen immer wieder und können so unempfindlich werden gegen ansonsten wirksame Behandlungsmethoden. Forschende der Medizinischen Fakultät der UDE suchen als Teil des Forschungsnetzwerkes SATURN3 nach den Gründen für entstandene Therapie-Resistenzen besonders gefährlicher Krebsarten. Sie möchten neue Wege finden, um widerstandsfähige Tumorzellen besser bekämpfen zu können. Das Bundesministerium für Bildung und Forschung (BMBF) fördert SATURN3 im Zuge der Nationalen Dekade gegen Krebs für 5 Jahre mit über 15 Millionen Euro.

Möglicher Zusammenhang mit COVID-19-Infektionen Veränderungen im Darmmikrobiom nachgewiesen
[18.11.2021] Personen mit einer COVID-19-Infektion haben eine weniger vielfältige Darmflora. Das hat ein Forschungsteam der Medizinischen Fakultät der Universität Duisburg-Essen (UDE) festgestellt. Bei COVID-19-Erkrankten häufen sich Bakterien, die mit verschiedenen entzündlichen Erkrankungen in Verbindung stehen – gleichzeitig gibt es weniger entzündungshemmende Bakterien. Die kürzlich in „Frontiers in Cellular and Infection Microbiology“ veröffentlichte Studie wurde von der Stiftung Universitätsmedizin Essen gefördert.

RESOLV: Cluster of Excellence Supercomputer im Kampf gegen Antibiotikaresistenzen
[18.11.2021] ZMB Mitglied Professorin Elsa Sánchez-García hat mit einem internationalen Team unter der Leitung von Forschern des Exzellenzclusters "Ruhr Explores Solvation" (RESOLV) eine Strategie entwickelt, mit Supercomputern der Gefahr von Krankheiten durch antibiotikaresistente Bakterien entgegenzuwirken. Dank Simulationsstrategien können Supercomputer dazu beitragen, die dringend benötigte Entwicklung neuer Antibiotikavarianten zu beschleunigen. Die Ergebnisse wurden am 16. November in der Zeitschrift Proceedings of the National Academy of Science, kurz PNAS, veröffentlicht. „Wir hoffen, mit dieser Studie zeigen zu können, dass die Resistenzmechanismen von Bakterien systematisch mit computergestützten Strategien angegangen werden können, die dazu beitragen, die Entwicklung neuer Antibiotika-Derivate schneller und kostengünstiger zu machen", erklärt Elsa Sanchez-Garcia, Leiterin der Gruppe Computational Biochemistry an der UDE und Principal Investigator von RESOLV.

Neuer SFB an der UDE Molekulare Mechanismen der Zellvermehrung entschlüsseln
[25.05.2021] Damit sich ein Organismus entwickeln und regenerieren kann, müssen sich Zellen vermehren. Während der Vermehrung werden nacheinander mehrere genau definierte Zustände durchlaufen, deren Übergänge strikt reguliert werden. Die hierfür zentralen molekularen Mechanismen untersucht jetzt ein neuer Sonderforschungsbereich (SFB), den die Deutsche Forschungsgemeinschaft (DFG) an der Universität Duisburg-Essen (UDE) eingerichtet hat. Dafür stehen in den nächsten vier Jahren rund 10 Millionen Euro zur Verfügung.
10.05.2022 - 09:30:00
6,9 Millionen Euro für Krebsforschung: Wie entziehen sich Tumoren der Strahlentherapie?
ZMB Research Programs
Oncology
The concept of this research program is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments.
Participating researchers from biology, experimental and clinical medicine study tumors as “biological systems" and so called “neo-organs”.
A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.
Immunology, Infectious Diseases and Transplantation
The immune system responds to various pathogens including viruses and bacteria in different ways to prevent severe disease and persistence in the host. Many pathogens, however, have developed mechanisms to evade immune defence.
The molecular and cellular interactions of pathogens with the immune system are studied within this program.
Molecular and Chemical Cell Biology
Molecular and chemical cell biology is an interdisciplinary research program connecting molecular cell biology and genetics with chemistry and structural biology. Scientists of the participating disciplines collaborate to advance the understanding of basic molecular mechanisms of important biological processes.
The analysis of regulation and deregulation of key pathways is linking basic biology with pathophysiology.
Latest Publications
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20-Year Steady Increase in Survival of Adult Patients with Relapsed Philadelphia-Positive Acute Lymphoblastic Leukemia Post Allogeneic Hematopoietic Cell TransplantationIn: Clinical Cancer Research Vol. 28 (2022) Nr. 5, pp. 1004 - 1012
ISSN: 1557-3265; 1078-0432Online Full Text: dx.doi.org/ -
ACKR3 regulates platelet activation and ischemia-reperfusion tissue injuryIn: Nature Communications Vol. 13 (2022) Nr. 1,
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor MicroenvironmentIn: Cancer Research Vol. 82 (2022) Nr. 2, pp. 264 - 277
ISSN: 1538-7445; 0099-7374Online Full Text: dx.doi.org/ -
Cardiotoxicity from chimeric antigen receptor-T cell therapy for advanced malignanciesIn: European Heart Journal (2022) in press
ISSN: 0195-668X; 1522-9645Online Full Text: dx.doi.org/ -
Cellular plasticity upon proton irradiation determines tumor cell radiosensitivityIn: Cell Reports Vol. 38 (2022) Nr. 8,
ISSN: 2211-1247Online Full Text: dx.doi.org/ (Open Access) -
DJ-1 depletion prevents immunoaging in T-cell compartmentsIn: EMBO Reports Vol. 23 (2022) Nr. 3,
ISSN: 1469-3178; 1469-221XOnline Full Text: dx.doi.org/ (Open Access) -
Gastrointestinal stromal tumours : ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-upIn: Annals of Oncology Vol. 33 (2022) Nr. 1, pp. 20 - 33
ISSN: 1569-8041; 0923-7534Online Full Text: dx.doi.org/ (Open Access) -
Imaging innate immunity*In: Immunological Reviews Vol. 306 (2022) Nr. 1, pp. 293 - 303
ISSN: 0105-2896; 1600-065XOnline Full Text: dx.doi.org/ (Open Access) -
Isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa-KRd) in front-line treatment of high-risk multiple myeloma : Interim analysis of the GMMG-CONCEPT trialIn: Leukemia Vol. 36 (2022) Nr. 3, pp. 885 - 888
ISSN: 1476-5551; 0887-6924Online Full Text: dx.doi.org/ (Open Access) -
Mapping the Regioisomeric Space and Visible Color Range of Purely Organic Dual Emitters with Ultralong Phosphorescence Components : From Violet to Red Towards Pure White LightIn: Angewandte Chemie International Edition Vol. 61 (2022) Nr. 4,
ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/ (Open Access) -
On the role of phase separation in the biogenesis of membraneless compartmentsIn: The EMBO Journal Vol. 41 (2022) Nr. 5,
ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/ (Open Access) -
Preneoplastic somatic mutations including MYD88L²⁶⁵P in lymphoplasmacytic lymphomaIn: Science Advances Vol. 8 (2022) Nr. 3,
ISSN: 2375-2548Online Full Text: dx.doi.org/ (Open Access) -
Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expressionIn: Nature Communications Vol. 13 (2022) Nr. 1,
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced MelanomaIn: The New England Journal of Medicine Vol. 386 (2022) Nr. 1, pp. 24 - 34
ISSN: 1533-4406; 0028-4793Online Full Text: dx.doi.org/ -
Results from a First-in-Human Phase I Study of Siremadlin (HDM201) in Patients with Advanced Wild-Type TP53 Solid Tumors and Acute LeukemiaIn: Clinical Cancer Research Vol. 28 (2022) Nr. 5, pp. 870 - 881
ISSN: 1557-3265; 1078-0432Online Full Text: dx.doi.org/ (Open Access) -
SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphomaIn: Blood Vol. 139 (2022) Nr. 4, pp. 538 - 553
ISSN: 1528-0020; 0006-4971Online Full Text: dx.doi.org/ -
Stroke induces disease-specific myeloid cells in the brain parenchyma and piaIn: Nature Communications Vol. 13 (2022) Nr. 1,
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochoresIn: The EMBO Journal (2022)
ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Targeting early stages of cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapyIn: European Heart Journal Vol. 43 (2022) Nr. 4, pp. 316 - 329
ISSN: 0195-668X; 1522-9645Online Full Text: dx.doi.org/ -
The role of DNA nanostructures in the catalytic properties of an allosterically regulated proteaseIn: Science Advances Vol. 8 (2022) Nr. 1,
ISSN: 2375-2548Online Full Text: dx.doi.org/ (Open Access) -
A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargosIn: Advanced Drug Delivery Reviews Vol. 173 (2021) pp. 479 - 491
ISSN: 1872-8294; 0169-409XOnline Full Text: dx.doi.org/ (Open Access) -
Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1In: Blood Vol. 137 (2021) Nr. 5, pp. 646 - 660
ISSN: 1528-0020; 0006-4971Online Full Text: dx.doi.org/ -
Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomasIn: Blood Vol. 137 (2021) Nr. 20, pp. 2785 - 2799
ISSN: 1528-0020; 0006-4971Online Full Text: dx.doi.org/ -
Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trialIn: The Lancet Oncology Vol. 22 (2021) Nr. 5, pp. 643 - 654
ISSN: 1474-5488; 1470-2045Online Full Text: dx.doi.org/ -
Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trialIn: The Lancet Oncology Vol. 22 (2021) Nr. 5, pp. 655 - 664
ISSN: 1474-5488; 1470-2045Online Full Text: dx.doi.org/ -
Agony of choice : How anesthetics affect the composition and function of extracellular vesiclesIn: Advanced Drug Delivery Reviews Vol. 175 (2021)
ISSN: 1872-8294; 0169-409XOnline Full Text: dx.doi.org/ -
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infectionIn: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1726
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Altered mitochondria functionality defines a metastatic cell state in lung cancer and creates an exploitable vulnerabilityIn: Cancer Research Vol. 81 (2021) Nr. 3, pp. 567 - 579
ISSN: 0008-5472; 1538-7445Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular VulnerabilitiesIn: Cancer Discovery Vol. 2 (2021) Nr. 1, pp. 70 - 91
ISSN: 2159-8290; 2159-8274Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Antibody-guided in vivo imaging of Aspergillus fumigatus lung infections during antifungal azole treatmentIn: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1707
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Assembly principles and stoichiometry of a complete human kinetochore moduleIn: Science Advances Vol. 7 (2021) Nr. 27,
ISSN: 2375-2548Online Full Text: dx.doi.org/ (Open Access) -
BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in MitosisIn: Molecular Cell Vol. 81 (2021) Nr. 1, pp. 67 - 87.e9
ISSN: 1097-4164; 1097-2765Online Full Text: dx.doi.org/ (Open Access) -
Bacterial protein domains with a novel Ig-like fold target human CEACAM receptorsIn: The EMBO Journal Vol. 40 (2021) Nr. 7, pp. e106103
ISSN: 1460-2075; 0261-4189Online Full Text: dx.doi.org/ (Open Access) -
CDC20 assists its catalytic incorporation in the mitotic checkpoint complexIn: Science Vol. 371 (2021) Nr. 6524, pp. 67 - 71
ISSN: 1095-9203; 0036-8075Online Full Text: dx.doi.org/ -
Cdc4 phospho-degrons allow differential regulation of ame1ceⁿp⁻u protein stability across the cell cycleIn: eLife Vol. 10 (2021)
ISSN: 2050-084XOnline Full Text: dx.doi.org/ (Open Access) -
Cellular model system to dissect the isoform-selectivity of Akt inhibitorsIn: Nature Communications Vol. 12 (2021) Nr. 1,
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib : A clinical validation studyIn: The Lancet Oncology Vol. 22 (2021) Nr. 3, pp. 370 - 380
ISSN: 1470-2045; 1474-5488Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS StudyIn: Clinical Cancer Research Vol. 27 (2021) Nr. 23, pp. 6333 - 6342
ISSN: 1557-3265; 1078-0432Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Coating of cochlear implant electrodes with bioactive DNA-loaded calcium phosphate nanoparticles for the local transfection of stimulatory proteinsIn: Biomaterials Vol. 276 (2021)
ISSN: 1878-5905; 0142-9612Online Full Text: dx.doi.org/ -
Comorbid medical conditions are a key factor to understand the relationship between psychiatric disorders and COVID-19-related mortality : Results from 49,089 COVID-19 inpatientsIn: Molecular Psychiatry (2021) in press
ISSN: 1359-4184; 1476-5578Online Full Text: dx.doi.org/ (Open Access) -
Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare CancersIn: Cancer Discovery Vol. 11 (2021) Nr. 11, pp. 2780 - 2795
ISSN: 2159-8290; 2159-8274Online Full Text: dx.doi.org/ -
Corrigendum to “Inhibiting fibroblast growth factor receptors in cancer – The next generation”In: Annals of Oncology Vol. 32 (2021) Nr. 1, pp. 126
ISSN: 1569-8041; 0923-7534Online Full Text: dx.doi.org/ (Open Access) -
EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumoursIn: Annals of Oncology Vol. 32 (2021) Nr. 11, pp. 1332 - 1347
ISSN: 0923-7534; 1569-8041Online Full Text: dx.doi.org/ (Open Access) -
Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypesIn: Nature Communications Vol. 12 (2021) Nr. 1, pp. 2048
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ SignalingIn: Hepatology Vol. 73 (2021) Nr. 2, pp. 486 - 502
ISSN: 1527-3350; 0270-9139Online Full Text: dx.doi.org/ -
GPR15 facilitates recruitment of regulatory T cells to promote colorectal cancerIn: Cancer Research Vol. 81 (2021) Nr. 11, pp. 2970 - 2982
ISSN: 1538-7445; 0008-5472Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access) -
In situ photothermal response of single gold nanoparticles through hyperspectral imaging anti-stokes thermometryIn: ACS Nano Vol. 15 (2021) Nr. 2, pp. 2458 - 2467
ISSN: 1936-0851; 1936-086XOnline Full Text: dx.doi.org/ (Open Access) -
Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infectionsIn: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1112
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Leadership challenges defusedIn: Science Vol. 371 (2021) Nr. 6533, pp. 1070
ISSN: 1095-9203; 0036-8075Online Full Text: dx.doi.org/ (Open Access) -
MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-IIn: Nature Communications Vol. 12 (2021) Nr. 1,
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Mapping the human genetic architecture of COVID-19In: Nature Vol. 600 (2021) pp. 472 - 477
ISSN: 0028-0836; 1476-4687Online Full Text: dx.doi.org/ (Open Access) -
Metabolic requirements of NK cells during the acute response against retroviral infectionIn: Nature Communications Vol. 12 (2021) Nr. 1,
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Molecular biology of Hodgkin lymphomaIn: Leukemia Vol. 35 (2021) Nr. 4, pp. 968 - 981
ISSN: 1476-5551; 0887-6924Online Full Text: dx.doi.org/ (Open Access) -
Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasionIn: Nature Genetics Vol. 53 (2021) Nr. 3, pp. 332 - 341
ISSN: 1061-4036; 1546-1718Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access) -
Multiple Hepatic and Pulmonary Tumors Combined with Bilateral Adrenal Masses in a Young Woman with von Hippel–Lindau DiseaseIn: Gastroenterology Vol. 161 (2021) Nr. 4, pp. e1 - e4
ISSN: 1528-0012; 0016-5085Online Full Text: dx.doi.org/ -
Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomasIn: Leukemia Vol. 35 (2021) pp. 2002 - 2016
ISSN: 0887-6924; 1476-5551Online Full Text: dx.doi.org/ (Open Access) -
Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatmentIn: Clinical Cancer Research Vol. 27 (2021) Nr. 12, pp. 3432 - 3442
ISSN: 1557-3265; 1078-0432Online Full Text: dx.doi.org/ -
NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defenceIn: Nature Communications Vol. 12 (2021) Nr. 1,
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Nab-paclitaxel plus gemcitabine versus nab-paclitaxel plus gemcitabine followed by FOLFIRINOX induction chemotherapy in locally advanced pancreatic cancer (NEOLAP-AIO-PAK-0113) : a multicentre, randomised, phase 2 trialIn: The Lancet Gastroenterology & Hepatology Vol. 6 (2021) Nr. 2, pp. 128 - 138
ISSN: 2468-1253Online Full Text: dx.doi.org/ -
Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal FluidIn: Immunity Vol. 54 (2021) Nr. 1, pp. 164
ISSN: 1097-4180; 1074-7613Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defectsIn: Molecular Psychiatry Vol. 26 (2021) Nr. 12, pp. 7403 - 7416
ISSN: 1476-5578; 1359-4184Online Full Text: dx.doi.org/ (Open Access) -
Neutrophils self-limit swarming to contain bacterial growth in vivoIn: Science Vol. 372 (2021) Nr. 6548,
ISSN: 1095-9203; 0036-8075Online Full Text: dx.doi.org/ -
New players in the regulation of DNA-PK activity : Survivin joins the crowdIn: Cancer Research Vol. 81 (2021) Nr. 9, pp. 2270 - 2271
ISSN: 1538-7445; 0008-5472Online Full Text: dx.doi.org/ -
Nuclear receptor coactivator NCOA3 regulates UV radiation⇓induced DNA damage and melanoma susceptibilityIn: Cancer Research Vol. 81 (2021) Nr. 11, pp. 2956 - 2969
ISSN: 1538-7445; 0008-5472Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilizationIn: Science Advances Vol. 7 (2021) Nr. 3, pp. eabc8590
ISSN: 2375-2548Online Full Text: dx.doi.org/ (Open Access) -
PI3KC2β inactivation stabilizes VE‐cadherin junctions and preserves vascular integrityIn: EMBO Reports (2021) pp. e51299
ISSN: 1469-3178; 1469-221XOnline Full Text: dx.doi.org/ Online Full Text (Open Access) -
PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected miceIn: EMBO Reports (2021)
ISSN: 1469-3178; 1469-221XOnline Full Text: dx.doi.org/ (Open Access) -
PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman PrimatesIn: Clinical Cancer Research Vol. 27 (2021) Nr. 7, pp. 2050 - 2060
ISSN: 1557-3265; 1078-0432Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access) -
Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DMIn: Blood Vol. 137 (2021) Nr. 7, pp. 923 - 928
ISSN: 0006-4971; 1528-0020Online Full Text: dx.doi.org/ -
Phase I assessment of safety and therapeutic activity of BAY1436032 in patients with IDH1-mutant solid tumorsIn: Clinical Cancer Research Vol. 27 (2021) Nr. 10, pp. 2723 - 2733
ISSN: 1078-0432; 1557-3265Online Full Text: dx.doi.org/ (Open Access) -
Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochoreIn: The EMBO Journal Vol. 40 (2021) Nr. 18,
ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/ (Open Access) -
Post-transplantation cyclophosphamide GvHD prophylaxis after hematopoietic stem cell transplantation from 9/10 or 10/10 HLA-matched unrelated donors for acute leukemiaIn: Leukemia Vol. 35 (2021) Nr. 2, pp. 585 - 594
ISSN: 1476-5551; 0887-6924Online Full Text: dx.doi.org/ -
Pralsetinib for patients with advanced or metastatic RET-altered thyroid cancer (ARROW) : a multi-cohort, open-label, registrational, phase 1/2 studyIn: The Lancet Diabetes and Endocrinology Vol. 9 (2021) Nr. 8, pp. 491 - 501
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Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to ImmunotherapiesIn: Cancer Research Vol. 81 (2021) Nr. 21, pp. 5540 - 5554
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Reply to E. HindiéIn: Journal of Clinical Oncology Vol. 39 (2021) Nr. 8, pp. 944 - 946
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Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19 : Current evidence and potential mechanismsIn: Molecular Psychiatry Vol. 26 (2021) Nr. 12, pp. 7098 - 7099
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Resistance to avapritinib in pdgfra-driven gist is caused by secondary mutations in the pdgfra kinase domainIn: Cancer Discovery Vol. 11 (2021) Nr. 1, pp. 108 - 125
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Role of Tumor-Infiltrating B Cells in Clinical Outcome of Patients with Melanoma Treated With Dabrafenib Plus TrametinibIn: Clinical Cancer Research Vol. 27 (2021) Nr. 16, pp. 4500 - 4510
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SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1813
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Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache : A multicentre, double-blind, randomised controlled trialIn: The Lancet Neurology Vol. 20 (2021) Nr. 1, pp. 29 - 37
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Scaled preparation of extracellular vesicles from conditioned mediaIn: Advanced Drug Delivery Reviews Vol. 177 (2021)
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Silica-coated calcium phosphate nanoparticles for gene silencing of NF-κB p65 by siRNA and their impact on cellular players of inflammationIn: Biomaterials Vol. 276 (2021) pp. 121013
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Single-Particle Hyperspectral Imaging Reveals Kinetics of Silver Ion Leaching from Alloy NanoparticlesIn: ACS Nano (2021) pp. 8363 - 8375
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Soft tissue and visceral sarcomas : ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆In: Annals of Oncology Vol. 32 (2021) Nr. 11,
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Sotorasib for Lung Cancers with KRAS p.G12C MutationIn: The New England Journal of Medicine (2021) in press
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Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezersIn: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1505
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Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasisIn: Cell Reports Vol. 37 (2021) Nr. 8,
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Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assembliesIn: Science Advances Vol. 7 (2021) Nr. 2, pp. eabd4413
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Sugar-modified B-cell receptors in DLBCLIn: Blood Vol. 138 (2021) Nr. 17, pp. 1512 - 1514
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TRIP6 functions in brain ciliogenesisIn: Nature Communications Vol. 12 (2021) Nr. 1,
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Targeted substrate loop insertion by VCP/p97 during PP1 complex disassemblyIn: Nature Structural & Molecular Biology Vol. 28 (2021) Nr. 12, pp. 964 - 971
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The West German heart and vascular center at university medicine EssenIn: European Heart Journal Vol. 42 (2021) Nr. 10, pp. 963 - 964
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The acid sphingomyelinase/ceramide system in COVID-19In: Molecular Psychiatry (2021) in press
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The biology of thermoacidophilic archaea from the order SulfolobalesIn: FEMS Microbiology Reviews Vol. 45 (2021) Nr. 4,
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Tumor-associated hematopoietic stem and progenitor cells positively linked to glioblastoma progressionIn: Nature Communications Vol. 12 (2021) Nr. 1,
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Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapyIn: Nature Communications Vol. 12 (2021) Nr. 1, pp. 346
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UMI or not UMI, that is the question for scRNA-seq zero-inflationIn: Nature Biotechnology Vol. 39 (2021) Nr. 2, pp. 158 - 159
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