Welcome to ZMB

Welcome to ZMB

The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.

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News & Events

© Nierhaus

Medbio Alumnus Congratulations Dr. Tim Nierhaus

We cordially congratulate Tim Nierhaus, an alumnus of our degree program „Medical Biology“. Tim successfully completed his doctorate at Cambridge University under the supervision of Jan Löwe, research leader at the MRC Laboratory of Molecular Biology (LMB).

Nierhaus, T. (2020). The bacterial actin-like cell division protein FtsA forms antiparallel double filaments upon binding of FtsN.
Thesis
Paper

© UDE/Frank Preuß

Neu an der UDE/am UK Essen: Sebastian Bauer Personalisierte Krebs-Therapie

[13.10.2021] Krebskranke mit einer Tablette ohne große Nebenwirkungen behandeln – ein onkologischer Traum. „Als ich mit der Tumorforschung begann, habe ich dieses – leider noch zu seltene – medizinische Wunder erlebt“, sagt Dr. Sebastian Bauer. Der neue Professor für Translationale Onkologie erforscht an der UDE-Fakultät für Medizin unter anderem personalisierte Tumortherapien. Er ist zugleich ärztlicher Leiter des Sarkomzentrums des UK Essen.

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© pixabay

Save the date Auf zu neuen Kooperationen

Seminar zum Austausch der Disziplinen

***
NEUE TERMINE
22.06.2022
21.09.2022
14.12.2022
von 14:30 – 16 Uhr
***

Interessierte SprecherInnen können sich gerne bei Dr. Maike Müller melden.

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© KFO 337

KFO 337 "PhenoTImE" International Symposium

„Phenotypic Therapy and Immune Escape in Cancer“

4th March 2022

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Press Releases 2021/2022

© Carpus+Partner AG

Neue Methoden für verschiedene Disziplinen Wissenschaftsrat empfiehlt Forschungsbau zu Katalyse

[29.04.2022] Meilenstein für die Grundlagenforschung an der UDE: Der Wissenschaftsrat hat den geplanten Forschungsbau ACTIVE SITES als förderungswürdig eingestuft. Das Vorhaben wird damit – vorbehaltlich der abschließenden Entscheidung der Gemeinsamen Wissenschaftskonferenz (GWK) – realisiert. Die Kosten für Bau und Ausstattung von 69 Millionen Euro übernehmen jeweils zur Hälfte der Bund und das Land Nordrhein-Westfalen. Die UDE erhält mit ACTIVE SITES ein Zentrum von internationaler Strahlkraft, an dem sogenannte aktive Zentren erforscht werden.

ACTIVE SITES

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© UDE/Labor Rösch

Folgeförderung für Krebsforschung Überlebensstrategie gefährlicher Tumore entschlüsselt

[06.04.2022] Wie schaffen es einige Tumore, sich gegen etablierte Krebstherapien und Medikamente erfolgreich zu wehren? Forschende der Medizinischen Fakultät der UDE verstehen das immer besser. Seit 2018 beschäftigen sie sich damit im Krebsforschungsverbund PhenoTImE, den die Deutsche Forschungsgemeinschaft (DFG) fördert. Dank vielversprechender Ergebnisse hat die DFG die Förderung jetzt um drei Jahre verlängert und stattet den Verbund mit weiteren knapp vier Millionen Euro aus.

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© UDE/ZHO

NRW fördert Netzwerke CANTAR (CANcer TARgeting) - Netzwerk zwischen Forschenden aus Chemie, Biologie und Medizin

[01.04.2022] Mit über 81 Millionen Euro fördert die NRW-Landesregierung ab August fünf herausragende Forschungsnetzwerke, um sie nachhaltig zu stärken. Es geht um die zukunftweisenden Themen Hirnforschung, Künstliche Intelligenz, Informationstechnik, Krebsbekämpfung und Teilchenphysik. An zwei der geförderten Verbünde ist die UDE beteiligt: terahertz.NRW sowie CANTAR erhalten in den kommenden vier Jahren bis zu 19,4 Millionen Euro, damit sie ihre Ideen weiterentwickeln können.

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research image of cancer cells
© Ferris Lab, UPMC Hillman Cancer Center, University of Pittsburgh

HNO-Krebs verstehen Blick ins Mikromilieu von Kopf-Hals-Tumoren

[07.02.2022] Krebs der Schleimhäute im HNO-Bereich, also in Mundhöhle, Rachen oder Kehlkopf ist die sechsthäufigste Tumorerkrankung. Wissenschaftler:innen der Medizinischen Fakultät der UDE haben nun mithilfe einer neuen Technik HNO-Plattenepithelkarzinome untersucht, um das Milieu im Tumor besser zu verstehen. Sie möchten so Ursachen für die Krebsentstehung klären und bessere Früherkennungs- und Behandlungsmethoden entwickeln. Ihre Erkenntnisse sind in „Nature Communications“ veröffentlicht.

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© UDE/Frank Preuß

Neue Emmy Noether-Gruppe Therapien für Hautkrebs verbessern

[12.01.2022] Die Deutsche Forschungsgemeinschaft (DFG) hat Prof. Dr. Dr. Alpaslan Tasdogan von der Medizinischen Fakultät der UDE in ihr renommiertes Emmy Noether-Programm aufgenommen. Damit fördert sie auch sein neues Krebsforschungsprojekt mit 1,9 Millionen Euro für die kommenden sechs Jahre. Tasdogan und sein Team suchen nach neuen Therapien, mit denen die Ausbreitung des Schwarzen Hautkrebses (Malignes Melanom) besser verhindert werden kann.

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© UDE/AG Hemmo Meyer

Breakdown of 3D Protein Structures Threaded as an Eyelet

[29.11.2021] It’s an old needlework trick, and a protein in our body knows it: Instead of threading yarn into the eye from the end, it can be easier to pass a loop through it. This is how a protein in our body works, unfolding or separating other protein structures. UDE's Biologists have made this discovery and published it in Nature Structural & Molecular Biology.

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© Liffers,Siveke Lab/Deutsche Krebshilfe

Über 15 Mio. Euro für Tumorforschung Resistente Krebszellen besser bekämpfen

[22.11.2021] Im Laufe einer Krebserkrankung verändern sich Tumorzellen immer wieder und können so unempfindlich werden gegen ansonsten wirksame Behandlungsmethoden. Forschende der Medizinischen Fakultät der UDE suchen als Teil des Forschungsnetzwerkes SATURN3 nach den Gründen für entstandene Therapie-Resistenzen besonders gefährlicher Krebsarten. Sie möchten neue Wege finden, um widerstandsfähige Tumorzellen besser bekämpfen zu können. Das Bundesministerium für Bildung und Forschung (BMBF) fördert SATURN3 im Zuge der Nationalen Dekade gegen Krebs für 5 Jahre mit über 15 Millionen Euro.

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© pixabay.com

Möglicher Zusammenhang mit COVID-19-Infektionen Veränderungen im Darmmikrobiom nachgewiesen

[18.11.2021] Personen mit einer COVID-19-Infektion haben eine weniger vielfältige Darmflora. Das hat ein Forschungsteam der Medizinischen Fakultät der Universität Duisburg-Essen (UDE) festgestellt. Bei COVID-19-Erkrankten häufen sich Bakterien, die mit verschiedenen entzündlichen Erkrankungen in Verbindung stehen – gleichzeitig gibt es weniger entzündungshemmende Bakterien. Die kürzlich in „Frontiers in Cellular and Infection Microbiology“ veröffentlichte Studie wurde von der Stiftung Universitätsmedizin Essen gefördert.

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© Elsa Sánchez-García

RESOLV: Cluster of Excellence Supercomputer im Kampf gegen Antibiotikaresistenzen

[18.11.2021] ZMB Mitglied Professorin Elsa Sánchez-García hat mit einem internationalen Team unter der Leitung von Forschern des Exzellenzclusters "Ruhr Explores Solvation" (RESOLV) eine Strategie entwickelt, mit Supercomputern der Gefahr von Krankheiten durch antibiotikaresistente Bakterien entgegenzuwirken. Dank Simulationsstrategien können Supercomputer dazu beitragen, die dringend benötigte Entwicklung neuer Antibiotikavarianten zu beschleunigen. Die Ergebnisse wurden am 16. November in der Zeitschrift Proceedings of the National Academy of Science, kurz PNAS, veröffentlicht. „Wir hoffen, mit dieser Studie zeigen zu können, dass die Resistenzmechanismen von Bakterien systematisch mit computergestützten Strategien angegangen werden können, die dazu beitragen, die Entwicklung neuer Antibiotika-Derivate schneller und kostengünstiger zu machen", erklärt Elsa Sanchez-Garcia, Leiterin der Gruppe Computational Biochemistry an der UDE und Principal Investigator von RESOLV.

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© ZMB/ ICCE

Neuer SFB an der UDE Molekulare Mechanismen der Zellvermehrung entschlüsseln

[25.05.2021] Damit sich ein Organismus entwickeln und regenerieren kann, müssen sich Zellen vermehren. Während der Vermehrung werden nacheinander mehrere genau definierte Zustände durchlaufen, deren Übergänge strikt reguliert werden. Die hierfür zentralen molekularen Mechanismen untersucht jetzt ein neuer Sonderforschungsbereich (SFB), den die Deutsche Forschungsgemeinschaft (DFG) an der Universität Duisburg-Essen (UDE) eingerichtet hat. Dafür stehen in den nächsten vier Jahren rund 10 Millionen Euro zur Verfügung.

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ZMB Research Programs

Oncology

The concept of this research program is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments.

Participating researchers from biology, experimental and clinical medicine study tumors as “biological systems" and so called “neo-organs”.

A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.

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Immunology, Infectious Diseases and Transplantation

The immune system responds to various pathogens including viruses and bacteria in different ways to prevent severe disease and persistence in the host. Many pathogens, however, have developed mechanisms to evade immune defence.

The molecular and cellular interactions of pathogens with the immune system are studied within this program.

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Molecular and Chemical Cell Biology

Molecular and chemical cell biology is an interdisciplinary research program connecting molecular cell biology and genetics with chemistry and structural biology. Scientists of the participating disciplines collaborate to advance the understanding of basic molecular mechanisms of important biological processes.

The analysis of regulation and deregulation of key pathways is linking basic biology with pathophysiology.

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Latest Publications

    Journal articles

  • Bazarbachi, Ali; Labopin, Myriam; Aljurf, Mahmoud; Niittyvuopio, Riitta; Balsat, Marie; Blaise, Didier; Yakoub-Agha, Ibrahim; Grassi, Anna; Reinhardt, Hans Christian; Lenhoff, Stig; Jindra, Pavel; Passweg, Jakob; Abou Dalle, Iman; Stadler, Michael; Lioure, Bruno; Ceballos, Patrice; Brissot, Eolia; Giebel, Sebastian; Nagler, Arnon; Schmid, Christoph; Mohty, Mohamad
    20-Year Steady Increase in Survival of Adult Patients with Relapsed Philadelphia-Positive Acute Lymphoblastic Leukemia Post Allogeneic Hematopoietic Cell Transplantation
    In: Clinical Cancer Research Vol. 28 (2022) Nr. 5, pp. 1004 - 1012
    ISSN: 1557-3265; 1078-0432
  • Rohlfing, Anne-Katrin; Kolb, Kyra; Sigle, Manuel; Ziegler, Melanie; Bild, Alexander; Münzer, Patrick; Sudmann, Jessica; Dicenta, Valerie; Harm, Tobias; Manke, Mailin-Christin; Geue, Sascha; Kremser, Marcel; Chatterjee, Madhumita; Liang, Chunguang; von Eysmondt, Hendrik; Dandekar, Thomas; Heinzmann, David; Günter, Manina; von Ungern-Sternberg, Saskia; Büttcher, Manuela; Castor, Tatsiana; Mencl, Stine; Langhauser, Friederike; Sies, Katharina; Ashour, Diyaa; Beker, Mustafa Caglar; Lämmerhofer, Michael; Autenrieth, Stella E.; Schäffer, Tilman E.; Laufer, Stefan; Szklanna, Paulina; Maguire, Patricia; Heikenwalder, Matthias; Müller, Karin Anne Lydia; Hermann, Dirk M.; Kilic, Ertugrul; Stumm, Ralf; Ramos, Gustavo; Kleinschnitz, Christoph; Borst, Oliver; Langer, Harald F.; Rath, Dominik; Gawaz, Meinrad
    ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury
    In: Nature Communications Vol. 13 (2022) Nr. 1,
    ISSN: 2041-1723
  • Liu, Wei; Stachura, Paweł; Xu, Haifeng C.; Váraljai, Renáta; Shinde, Prashant; Ganesh, Nikkitha Umesh; Mack, Matthias; Van Lierop, Anke; Huang, Anfei; Sundaram, Balamurugan; Lang, Karl S.; Picard, Daniel; Fischer, Ute; Remke, Marc; Homey, Bernhard; Rösch, Alexander; Häussinger, Dieter; Lang, Philipp A.; Borkhardt, Arndt; Pandyra, Aleksandra A.; Stachura, Pawel; Umesh Ganesh, Nikkitha
    BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment
    In: Cancer Research Vol. 82 (2022) Nr. 2, pp. 264 - 277
    ISSN: 1538-7445; 0099-7374
  • Totzeck, Matthias; Michel, Lars; Lin, Yi; Herrmann, Joerg; Rassaf, Tienush
    Cardiotoxicity from chimeric antigen receptor-T cell therapy for advanced malignancies
    In: European Heart Journal (2022) in press
    ISSN: 0195-668X; 1522-9645
  • Schniewind, Iñaki; Hadiwikarta, Wahyu Wijaya; Grajek, Julia; Poleszczuk, Jan; Richter, Susan; Peitzsch, Mirko; Müller, Johannes; Klusa, Daria; Beyreuther, Elke; Löck, Steffen; Lühr, Armin; Frosch, Susanne; Groeben, Christer; Sommer, Ulrich; Krause, Mechthild; Dubrovska, Anna; von Neubeck, Cläre; Kurth, Ina; Peitzsch, Claudia
    Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity
    In: Cell Reports Vol. 38 (2022) Nr. 8,
    ISSN: 2211-1247
  • Zeng, Ni; Capelle, Christophe M.; Baron, Alexandre; Kobayashi, Takumi; Cire, Severine; Tslaf, Vera; Leonard, Cathy; Coowar, Djalil; Koseki, Haruhiko; Westendorf, Astrid; Buer, Jan; Brenner, Dirk; Krüger, Rejko; Balling, Rudi; Ollert, Markus; Hefeng, Feng Q.
    DJ-1 depletion prevents immunoaging in T-cell compartments
    In: EMBO Reports Vol. 23 (2022) Nr. 3,
    ISSN: 1469-3178; 1469-221X
  • Casali, P. G.; Blay, J. Y.; Bauer, Sebastian; Stacchiotti, S.; et al.
    Gastrointestinal stromal tumours : ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up
    In: Annals of Oncology Vol. 33 (2022) Nr. 1, pp. 20 - 33
    ISSN: 1569-8041; 0923-7534
  • Grüneboom, Anika; Aust, Oliver; Cibir, Zülal; Weber, Flora; Hermann, Dirk M.; Gunzer, Matthias
    Imaging innate immunity*
    In: Immunological Reviews Vol. 306 (2022) Nr. 1, pp. 293 - 303
    ISSN: 0105-2896; 1600-065X
  • Leypoldt, Lisa B.; Besemer, Britta; Asemissen, Anne Marie; Hänel, Mathias; Blau, Igor Wolfgang; Görner, Martin; Ko, Yon-Dschun; Reinhardt, Christian; Staib, Peter; Mann, Christoph; Lutz, Raphael; Munder, Markus; Graeven, Ullrich; Peceny, Rudolf; Salwender, Hans; Jauch, Anna; Zago, Manola; Benner, Axel; Tichy, Diana; Bokemeyer, Carsten; Goldschmidt, Hartmut; Weisel, Katja C.
    Isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa-KRd) in front-line treatment of high-risk multiple myeloma : Interim analysis of the GMMG-CONCEPT trial
    In: Leukemia Vol. 36 (2022) Nr. 3, pp. 885 - 888
    ISSN: 1476-5551; 0887-6924
  • Roy, Bibhisan; Maisuls, Iván; Zhang, Jianyu; Niemeyer, Felix; Rizzo, Fabio; Wölper, Christoph; Daniliuc, Constantin G.; Tang, Ben Zhong; Strassert, Cristian A.; Voskuhl, Jens
    Mapping the Regioisomeric Space and Visible Color Range of Purely Organic Dual Emitters with Ultralong Phosphorescence Components : From Violet to Red Towards Pure White Light
    In: Angewandte Chemie International Edition Vol. 61 (2022) Nr. 4,
    ISSN: 1521-3773; 1433-7851; 0570-0833
  • Musacchio, Andrea
    On the role of phase separation in the biogenesis of membraneless compartments
    In: The EMBO Journal Vol. 41 (2022) Nr. 5,
    ISSN: 0261-4189; 1460-2075
  • Rodriguez, Sara; Celay, Jon; Goicoechea, Ibai; Jimenez, Cristina; Botta, Cirino; Garcia-Barchino, Maria-José; Garces, Juan-Jose; Larrayoz, Marta; Santos, Susana; Alignani, Diego; Vilas-Zornoza, Amaia; Perez, Cristina; Garate, Sonia; Sarvide, Sarai; Lopez, Aitziber; Reinhardt, Christian; Carrasco, Yolanda R.; Sanchez-Garcia, Isidro; Larrayoz, Maria-Jose; Calasanz, Maria-Jose; Panizo, Carlos; Prosper, Felipe; Lamo-Espinosa, Jose-Maria; Motta, Marina; Tucci, Alessandra; Sacco, Antonio; Gentile, Massimo; Duarte, Sara; Vitoria, Helena; Geraldes, Catarina; Paiva, Artur; Puig, Noemi; Garcia-Sanz, Ramon; Roccaro, Aldo M.; Fuerte, Gema; San Miguel, Jesus F.; Martinez-Climent, Jose-Angel; Paiva, Bruno
    Preneoplastic somatic mutations including MYD88L²⁶⁵P in lymphoplasmacytic lymphoma
    In: Science Advances Vol. 8 (2022) Nr. 3,
    ISSN: 2375-2548
  • Cheung, Phyllis F.; Yang, JiaJin; Fang, Rui; Borgers, Arianna; Krengel, Kirsten; Stoffel, Anne; Althoff, Kristina; Yip, Chi Wai; Siu, Elaine H. L.; Ng, Linda W. C.; Lang, Karl S.; Cham, Lamin B.; Engel, Daniel Robert; Soun, Camille; Cima, Igor; Scheffler, Björn; Striefler, Jana K.; Sinn, Marianne; Bahra, Marcus; Pelzer, Uwe; Oettle, Helmut; Markus, Peter; Smeets, Esther M. M.; Aarntzen, Erik H. J. G.; Savvatakis, Konstantinos; Liffers, Sven-Thorsten; Lueong, Smiths S.; Neander, Christian; Bazarna, Anna; Zhang, Xin; Paschen, Annette; Crawford, Howard C.; Chan, Anthony W. H.; Cheung, Siu Tim; Siveke, Jens
    Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression
    In: Nature Communications Vol. 13 (2022) Nr. 1,
    ISSN: 2041-1723
  • Tawbi, Hussein A.; Schadendorf, Dirk; Lipson, Evan J.; Ascierto, Paolo A.; Matamala, Luis; Castillo Gutiérrez, Erika; Rutkowski, Piotr; Gogas, Helen J.; Lao, Christopher D.; De Menezes, Juliana Janoski; Dalle, Stéphane; Arance, Ana; Grob, Jean-Jacques; Srivastava, Shivani; Abaskharoun, Mena; Hamilton, Melissa; Keidel, Sarah; Simonsen, Katy L.; Sobiesk, Anne Marie; Li, Bin; Hodi, F. Stephen; Long, Georgina V.
    Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma
    In: The New England Journal of Medicine Vol. 386 (2022) Nr. 1, pp. 24 - 34
    ISSN: 1533-4406; 0028-4793
  • Stein, Eytan M.; DeAngelo, Daniel J.; Chromik, Jörg; Chatterjee, Manik; Bauer, Sebastian; Lin, Chia-Chi; Suarez, Cristina; de Vos, Filip; Steeghs, Neeltje; Cassier, Philippe A.; Tai, David; Kiladjian, Jean-Jacques; Yamamoto, Noboru; Mous, Rogier; Esteve, Jordi; Minami, Hironobu; Ferretti, Stephane; Guerreiro, Nelson; Meille, Christophe; Radhakrishnan, Rajkumar; Pereira, Bernard; Mariconti, Luisa; Halilovic, Ensar; Fabre, Claire; Carpio, Cecilia; Cassier, Phillippe A.
    Results from a First-in-Human Phase I Study of Siremadlin (HDM201) in Patients with Advanced Wild-Type TP53 Solid Tumors and Acute Leukemia
    In: Clinical Cancer Research Vol. 28 (2022) Nr. 5, pp. 870 - 881
    ISSN: 1557-3265; 1078-0432
  • Wilke, Anne C.; Doebele, Carmen; Zindel, Alena; Lee, Kwang Seok; Rieke, Sara A.; Ceribelli, Michele; Comoglio, Federico; Phelan, James D.; Wang, James Q.; Pikman, Yana; Jahn, Dominique; Häupl, Björn; Schneider, Constanze; Scheich, Sebastian; Tosto, Frances A.; Bohnenberger, Hanibal; Stauder, Philipp; Schnütgen, Frank; Slabicki, Mikolaj; Coulibaly, Zana A.; Wolf, Sebastian; Bojarczuk, Kamil; Chapuy, Björn; Brandts, Christian H.; Stroebel, Philipp; Lewis, Caroline A.; Engelke, Michael; Xu, Xincheng; Kim, Hahn; Dang, Thanh Hung; Schmitz, Roland; Hodson, Daniel J.; Stegmaier, Kimberly; Urlaub, Henning; Serve, Hubert; Schmitt, Clemens A.; Kreuz, Fernando; Knittel, Gero; Rabinowitz, Joshua D.; Reinhardt, Christian; Vander Heiden, Matthew G.; Thomas, Craig; Staudt, Louis M.; Zenz, Thorsten; Oellerich, Thomas
    SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma
    In: Blood Vol. 139 (2022) Nr. 4, pp. 538 - 553
    ISSN: 1528-0020; 0006-4971
  • Beuker, Carolin; Schafflick, David; Strecker, Jan-Kolja; Heming, Michael; Li, Xiaolin; Wolbert, Jolien; Schmidt-Pogoda, Antje; Thomas, Christian; Kuhlmann, Tanja; Aranda-Pardos, Irene; A-Gonzalez, Noelia; Kumar, Praveen Ashok; Werner, Yves; Kilic, Ertugrul; Hermann, Dirk M.; Wiendl, Heinz; Stumm, Ralf; Hörste, Gerd Meyer Zu; Minnerup, Jens
    Stroke induces disease-specific myeloid cells in the brain parenchyma and pia
    In: Nature Communications Vol. 13 (2022) Nr. 1,
    ISSN: 2041-1723
  • Raisch, Tobias; Ciossani, Giuseppe; d’Amico, Ennio; Cmentowski, Verena; Carmignani, Sara; Maffini, Stefano; Merino, Felipe; Wohlgemuth, Sabine; Vetter, Ingrid R.; Raunser, Stefan; Musacchio, Andrea
    Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochores
    In: The EMBO Journal (2022)
    ISSN: 0261-4189; 1460-2075
  • Michel, Lars; Helfrich, Iris; Hendgen-Cotta, Ulrike Barbara; Mincu, Raluca-Ileana; Korste, Sebastian; Mrotzek, Simone Maria; Spomer, Armin; Odersky, Andrea; Rischpler, Christoph; Herrmann, Ken; Umutlu, Lale; Coman, Cristina; Ahrends, Robert; Sickmann, Albert; Löffek, Stefanie; Livingstone, Elisabeth; Ugurel, Selma; Zimmer, Lisa; Gunzer, Matthias; Schadendorf, Dirk; Totzeck, Matthias; Rassaf, Tienush
    Targeting early stages of cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapy
    In: European Heart Journal Vol. 43 (2022) Nr. 4, pp. 316 - 329
    ISSN: 0195-668X; 1522-9645
  • Kosinski, Richard; Perez, Joel Mieres; Schöneweiß, Elisa-C.; Ruiz-Blanco, Yasser B.; Ponzo, Irene; Bravo-Rodriguez, Kenny; Erkelenz, Michael; Schlücker, Sebastian; Uhlenbrock, Guido; Sánchez-García, Elsa; Sacca, Barbara
    The role of DNA nanostructures in the catalytic properties of an allosterically regulated protease
    In: Science Advances Vol. 8 (2022) Nr. 1,
    ISSN: 2375-2548
  • Rankin-Turner, Stephanie; Vader, Pieter; O'Driscoll, Lorraine; Giebel, Bernd; Heaney, Liam M.; Davies, Owen G.
    A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos
    In: Advanced Drug Delivery Reviews Vol. 173 (2021) pp. 479 - 491
    ISSN: 1872-8294; 0169-409X
  • Kohlhaas, Vivien; Blakemore, Stuart James; Al-Maarri, Mona; Nickel, Nadine; Pal, Martin; Roth, Andreas; Hövelmeyer, Nadine; Schäfer, Stephan C.; Knittel, Gero; Lohneis, Philipp; Nikolic, Milos; Wiederstein, Janica L.; Franitza, Marek; Georgomonolis, Theodoros; Reinart, Nina; Herling, Marco; Herling, Carmen; Hartmann, Elena M.; Rosenwald, Andreas; Klapper, Wolfram; Büttner, Reinhard; Moia, Riccardo; Rossi, Davide; Boldorini, Renzo; Gaidano, Gianluca; Frenzel, Lukas P.; Reinhardt, Christian; Brüning, Jens C.; Hallek, Michael; Krüger, Marcus; Peifer, Martin; Pallasch, Christian P.; Wunderlich, F. Thomas
    Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1
    In: Blood Vol. 137 (2021) Nr. 5, pp. 646 - 660
    ISSN: 1528-0020; 0006-4971
  • Reimann, Maurice; Schrezenmeier, Jens; Richter-Pechanska, Paulina; Dolnik, Anna; Hick, Timon Pablo; Schleich, Kolja; Cai, Xiurong; Fan, Dorothy N. Y.; Lohneis, Philipp; Maßwig, Sven; Denker, Sophy; Busse, Antonia; Knittel, Gero; Flümann, Ruth; Childs, Dorothee; Childs, Liam; Gätjens-Sanchez, Ana-Maria; Bullinger, Lars; Rosenwald, Andreas; Reinhardt, Christian; Schmitt, Clemens A.
    Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas
    In: Blood Vol. 137 (2021) Nr. 20, pp. 2785 - 2799
    ISSN: 1528-0020; 0006-4971
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    Sotorasib for Lung Cancers with KRAS p.G12C Mutation
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