Welcome to ZMB
Welcome to ZMB
The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.
News & Events
New targets for cancer therapies Röntgen Prize for PD Dr. Johann Matschke
Congratulations: The renowned 15,000 euro Röntgen Prize of Justus Liebig University Giessen this year goes to cell biologist PD Dr. Johann Matschke from Essen University Hospital. ZMB member and radiation researcher Johann Matschke receives the prize for his research into the radiation resistance of cancer cells. He has discovered that the defense systems of tumor cells that have become resistant to radiotherapy can be impaired in such a way that the cells are again vulnerable to reactive oxygen radicals and thus to radiation, and hopes to derive new biomarkers for radiation resistance from his findings.
Mike Blüggel Awarded Joachim Herz Add-on Fellowship
Congratulations to Mike Blüggel on receiving the Joachim Herz Add-on Fellowship for "Innovative Tumor Treatment Project"! His project "Sundowner", explores light-controlled protein degradation using nanobody-PHOTACs in collaboration with UDE´s Faculty of Chemistry. The goal is to combine PHOTACs with nanobodies to enable targeted degradation of the apoptosis inhibitor Survivin in tumor tissue, thereby protecting healthy tissue.
The fellowship enables research stays, conference attendance, training, science communication activities, and participation in fellowship meetings.
Congrats! Funding Award for Kathrin Thedieck
[25.10.2024] For her research into the development of new therapeutic approaches for the rare disease tuberous sclerosis, Professor Kathrin Thedieck has now received the Klüh Foundation's EUR 25,000 funding prize, which is awarded to promote innovation in science and research. Kathrin Thedieck, head of the “Metabolism, Senescence and Autophagy” department at the newly founded Research Center One Health of the University Alliance Ruhr, has been supporting the tuberous sclerosis movement in Germany for many years, and not just scientifically.
Read moreCRC1430 Guest Speaker Series
28.01.2025
Sascha Martens, Vienna BioCenter (VBC), Max Perutz Labs, University of Vienna
18.02.2025
Hana Polasek-Sedlackova, Institute of Biophysics, Czech Academy of Sciences
28.02.2025
Helge Ewers, Institute for Chemistry and Biochemistry, Freie Universität Berlin
Press Releases 2024
"Highly Cited Researchers 2024" Sieben UDE-Forschende werden häufig zitiert
[05.12.2024]
Täglich sammeln Wissenschaftler:innen der UDE wichtige Erkenntnisse und veröffentlichen neue Forschungsergebnisse für ihre Disziplinen. Sieben von ihnen gehören zu den "Highly Cited Researchers 2024". Sie zählen damit zu den ein Prozent der weltweit einflussreichsten Wissenschaftler:innen. Die renommierte Liste von Clarivate würdigt Arbeiten, die weltweit besonders häufig zitiert werden und somit maßgeblichen Einfluss auf das jeweilige Fachgebiet und/ oder über alle Disziplinen hinweg haben.
ZMB Member: Prof. Dr. Alexander Probst
ZMB Member: Prof. Dr. Dirk Schadendorf
UA Ruhr 27 neue Forschungsprofessuren besetzt
[02.12.2024] Die vier Research Center sowie das College der Universitätsallianz Ruhr (UA Ruhr) bilden ein neues forschungsstarkes Zentrum in der Wissenschaftsmetropole Ruhrgebiet. Bereits 27 internationale Spitzenwissenschaftler:innen haben sich für eine Zukunft in der UA Ruhr und damit an einer der drei Partneruniversitäten, der Ruhr-Universität Bochum, der Technischen Universität Dortmund oder der Universität Duisburg-Essen, entschieden. Insgesamt werden mehr als 50 neue Forschungsprofessuren innerhalb der Center und des College geschaffen.
ZMB Member: Prof. Dr. Dana Branzei
ZMB Member: Prof. Dr. Alexander Probst
Sonderforschungsbereich RESIST verlängert Auszeichnung für Spitzen-Wasserforschung
[25.11.2024]
Ein wichtiger Erfolg für die Wasserforschung an der Universität Duisburg-Essen: Der Sonderforschungsbereich (SFB) RESIST wird von der Deutschen Forschungsgemeinschaft (DFG) um vier Jahre verlängert. Seit 2021 erforschen die Gewässerexpert:innen der Universität Duisburg-Essen, wie Flüsse auf Klimawandel, Verschmutzung und Verbau reagieren – und wie sie sich von Belastungen erholen können. In der zweiten Phase stellt die DFG nun etwa 14 Millionen Euro bereit.
ZMB Member: Prof. Dr. Alexander Probst
Rund sechs Millionen Euro fließen in neues Graduiertenkolleg DFG fördert Forschung zur Protonentherapie an der Universitätsallianz Ruhr
[18.11.2024] In Zukunft können Nachwuchswissenschaftler:innen im Ruhrgebiet an der Schnittstelle zwischen Physik, Chemie und Medizin promovieren und das zukunftsträchtige Themenfeld der Protonentherapie erforschen: Die Deutsche Forschungsgemeinschaft (DFG) hat die Einrichtung des Graduiertenkollegs 3043 „AMTEC-PRO“ an der TU Dortmund und der Universität Duisburg-Essen beschlossen. Sie fördert das Graduiertenkolleg (GRK) ab Oktober 2025 für zunächst fünf Jahre mit insgesamt rund sechs Millionen Euro. Sprecher des Kollegs ist Prof. Kevin Kröninger von der Fakultät Physik der TU Dortmund.
Mitochondriale DNA-Mutationen Bremse oder Antrieb der Krebsentwicklung?
[06.11.2024] Genetische Veränderungen in der DNA der Mitochondrien spielen bei vielen erblichen Krebserkrankungen eine entscheidende Rolle. Diese Veränderungen beeinflussen auch die Entstehung und das Wachstum von schwarzem Hautkrebs, haben Forschende der Universität Duisburg-Essen und der University of Texas (USA) jetzt in Laborversuchen mit einem neu entwickelten Krebsmodell zeigen können.
Ministerpräsident Hendrik Wüst MdL und NRW-Wissenschaftsministerin Ina Brandes MdL eröffnen Research Center One Health Ruhr UA Ruhr-Spitzenforschung in Gesundheit, Umwelt und Gesellschaft
[04.11.2024]
Die heutige Eröffnung des Research Centers One Health Ruhr durch Ministerpräsident Hendrik Wüst MdL und NRW-Wissenschaftsministerin Ina Brandes definiert neue Maßstäbe für eine interdisziplinäre und international wettbewerbsfähige Spitzenforschung in Gesundheit, Umwelt und Gesellschaft. Der Ansatz ist neuartig: Am Research Center One Health Ruhr werden die komplexen Wechselbeziehungen zwischen menschlicher Gesundheit und Umweltgesundheit erforscht. Von den geplanten 14 Forschungsprofessuren konnten bereits acht mit international herausragenden Spitzenwissenschaftler:innen an der Universität Duisburg-Essen, der Ruhr-Universität Bochum und der TU Dortmund besetzt werden. Die drei Partner der Universitätsallianz Ruhr tragen das Research Center One Health Ruhr gemeinsam als Teil der Research Alliance Ruhr.
ZMB Member:
Prof. Dr. Alexander Probst,
Prof. Dr. Kathrin Thedieck
05.12.2024 - 11:11:18
Neu an UDE/UK Essen: Prof. Dr. Marcin Krawczyk Frühwarnsystem für Leber-Erkrankungen
ZMB Research Programs
Oncology
The concept of this research program is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments.
Participating researchers from biology, experimental and clinical medicine study tumors as “biological systems" and so called “neo-organs”.
A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.
Immunology, Infectious Diseases and Transplantation
The immune system responds to various pathogens including viruses and bacteria in different ways to prevent severe disease and persistence in the host. Many pathogens, however, have developed mechanisms to evade immune defence.
The molecular and cellular interactions of pathogens with the immune system are studied within this program.
Molecular and Chemical Cell Biology
Molecular and chemical cell biology is an interdisciplinary research program connecting molecular cell biology and genetics with chemistry and structural biology. Scientists of the participating disciplines collaborate to advance the understanding of basic molecular mechanisms of important biological processes.
The analysis of regulation and deregulation of key pathways is linking basic biology with pathophysiology.
Latest Publications
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A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanomaIn: Cell Vol. 187 (2024) Nr. 1, pp. 166 - 183.e25Online Full Text: dx.doi.org/ (Open Access)
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A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathwayIn: Nature Nanotechnology Vol. 19 (2024) Nr. 10, pp. 1521 - 1531Online Full Text: dx.doi.org/ (Open Access)
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A validation strategy to assess the role of phase separation as a determinant of macromolecular localizationIn: Molecular Cell Vol. 84 (2024) Nr. 9, pp. 1783 - 1801.e7Online Full Text: dx.doi.org/ (Open Access)
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Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : Long-term, health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trialIn: The Lancet Oncology Vol. 25 (2024) Nr. 9, pp. 1202 - 1212Online Full Text: dx.doi.org/
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Alteration of LARGE1 abundance in patients and a mouse model of 5q-associated spinal muscular atrophyIn: Acta Neuropathologica Vol. 147 (2024) Nr. 1, 53Online Full Text: dx.doi.org/ (Open Access)
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Amivantamab plus lazertinib versus osimertinib in first-line EGFR-mutant advanced non-small-cell lung cancer with biomarkers of high-risk disease : a secondary analysis from MARIPOSAIn: Annals of Oncology Vol. 35 (2024) Nr. 9, pp. 805 - 816Online Full Text: dx.doi.org/ (Open Access)
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An atlas of cells in the human tonsilIn: Immunity Vol. 57 (2024) Nr. 2, pp. 379 - 399.e18Online Full Text: dx.doi.org/ (Open Access)
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Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRAIn: Nature Communications Vol. 15 (2024) Nr. 1, 63Online Full Text: dx.doi.org/ (Open Access)
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BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathwayIn: Science Advances Vol. 10 (2024) Nr. 36, eadn9361Online Full Text: dx.doi.org/ (Open Access)
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Cardiac wasting and cancerIn: European Heart Journal Vol. 45 (2024) Nr. 34, pp. 3135 - 3137Online Full Text: dx.doi.org/ (Open Access)
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Cell-mediated cytotoxicity within CSF and brain parenchyma in spinal muscular atrophy unaltered by nusinersen treatmentIn: Nature Communications Vol. 15 (2024) Nr. 1, 4120Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Clinical Benefit of Avapritinib in KIT-Mutant Gastrointestinal Stromal Tumors : A Post Hoc Analysis of the Phase I NAVIGATOR and Phase I/II CS3007-001 StudiesIn: Clinical Cancer Research Vol. 30 (2024) Nr. 4, pp. 719 - 728Online Full Text: dx.doi.org/
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Cranioencephalic functional lymphoid units in glioblastomaIn: Nature Medicine (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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De novo and salvage purine synthesis pathways across tissues and tumorsIn: Cell Vol. 187 (2024) Nr. 14, pp. 3602 - 3618.e20Online Full Text: dx.doi.org/
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Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDSIn: Blood Vol. 144 (2024) Nr. 16, pp. 1747 - 1751Online Full Text: dx.doi.org/
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Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNAIn: Blood Vol. 143 (2024) Nr. 6, pp. 522 - 534Online Full Text: dx.doi.org/
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Evolutionary trajectories of small cell lung cancer under therapyIn: Nature Vol. 627 (2024) Nr. 8005, pp. 880 - 889Online Full Text: dx.doi.org/ (Open Access)
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Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III MelanomaIn: The New England Journal of Medicine (2024) in pressOnline Full Text: dx.doi.org/
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Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulationIn: Molecular Psychiatry (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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Günter Wulff (1935 –2023) : Father of Molecular ImprintingIn: Angewandte Chemie International Edition Vol. 63 (2024) Nr. 12, e202402244Online Full Text: dx.doi.org/ (Open Access)
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HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replicationIn: Journal of Hepatology (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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In situ Cyclization of Aromatic Thioethers in Emissive Materials to Generate Phosphorescent DibenzothiophenesIn: Angewandte Chemie International Edition (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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Lysosomal damage sensing and lysophagy initiation by SPG20-ITCHIn: Molecular Cell (2024) pp. 1556 - 1569.e10Online Full Text: dx.doi.org/ (Open Access)
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Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptorIn: Current Biology Vol. 34 (2024) Nr. 11, pp. 2279 - 2293.e6Online Full Text: dx.doi.org/ (Open Access)
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N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1In: Angewandte Chemie International Edition Vol. 63 (2024) Nr. 12, e202318849Online Full Text: dx.doi.org/ (Open Access)
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Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer : A randomized phase 2 trialIn: Nature Medicine Vol. 30 (2024) Nr. 6, pp. 1602 - 1611Online Full Text: dx.doi.org/ (Open Access)
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Pathogenic mitochondrial DNA mutations inhibit melanoma metastasisIn: Science Advances Vol. 10 (2024) Nr. 44, eadk8801Online Full Text: dx.doi.org/ (Open Access)
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Rational correction of pathogenic conformational defects in HTRA1In: Nature Communications Vol. 15 (2024) Nr. 1, 5944Online Full Text: dx.doi.org/ (Open Access)
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Regulation of minimal spindle midzone organization by mitotic kinasesIn: Nature Communications Vol. 15 (2024) Nr. 1, 9213Online Full Text: dx.doi.org/ (Open Access)
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Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesisIn: Science Vol. 386 (2024) Nr. 6722, pp. eado6836Online Full Text: dx.doi.org/
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Ripretinib versus sunitinib in gastrointestinal stromal tumor : ctDNA biomarker analysis of the phase 3 INTRIGUE trialIn: Nature Medicine Vol. 30 (2024) Nr. 2, pp. 498 - 506Online Full Text: dx.doi.org/ (Open Access)
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Role of protein kinase PLK1 in the epigenetic maintenance of centromeresIn: Science Vol. 385 (2024) Nr. 6713, pp. 1091 - 1097Online Full Text: dx.doi.org/
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Routine extracorporeal life support in infarct-related cardiogenic shock : 1-year results of the ECLS-SHOCK trialIn: European Heart Journal Vol. 45 (2024) Nr. 39, pp. 4200 - 4203Online Full Text: dx.doi.org/ (Open Access)
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Short-term post-fast refeeding enhances intestinal stemness via polyaminesIn: Nature (2024) in pressOnline Full Text: dx.doi.org/
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Structure of the human KMN complex and implications for regulation of its assemblyIn: Nature Structural & Molecular Biology Vol. 31 (2024) Nr. 6, pp. 861 - 873Online Full Text: dx.doi.org/ (Open Access)
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Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1In: Nucleic Acids Research Vol. 52 (2024) Nr. 20, pp. 12616 - 12632Online Full Text: dx.doi.org/ (Open Access)
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T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vesselsIn: Immunity (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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The journey to understand previously unknown microbial genesIn: Nature Vol. 626 (2024) Nr. 7998, pp. 267 - 269Online Full Text: dx.doi.org/ (Open Access)
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Thirty years of structural changesIn: Nature Structural & Molecular Biology Vol. 31 (2024) Nr. 1, pp. 4 - 5Online Full Text: dx.doi.org/
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TopBP1 utilises a bipartite GINS binding mode to support genome replicationIn: Nature Communications Vol. 15 (2024) Nr. 1, 1797Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
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VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substratesIn: Nature Communications Vol. 15 (2024) Nr. 1, 2459Online Full Text: dx.doi.org/ (Open Access)
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Vimseltinib versus placebo for tenosynovial giant cell tumour (MOTION) : a multicentre, randomised, double-blind, placebo-controlled, phase 3 trialIn: Lancet Vol. 403 (2024) Nr. 10445, pp. 2709 - 2719Online Full Text: dx.doi.org/
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XPO1-Mediated mRNA Export of Genome Maintenance Regulators Drives Chemotherapy Resistance in Aggressive LymphomaIn: Cancer Research Vol. 84 (2024) Nr. 1, pp. 3 - 5Online Full Text: dx.doi.org/
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iSERS : From nanotag design to protein assays and ex vivo imagingIn: Chemical Society Reviews Vol. 53 (2024) Nr. 13, pp. 6675 - 6693Online Full Text: dx.doi.org/ (Open Access)
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tracerDB : a crowdsourced fluorescent tracer database for target engagement analysisIn: Nature Communications Vol. 15 (2024) Nr. 1, 5646Online Full Text: dx.doi.org/ (Open Access)