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The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.

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(University of Duisburg-Essen)

21.12.2020 Tumor researcher honored

Dr. Johann Matschke, young scientist at the Institute of Cell Biology (Tumor Research) was awarded the Dieter-Frankenberg-Nachwuchspreis of the German Society for Biological Radiation Research. He received the award, endowed with 2,000 euros, for his outstanding work on the elucidation of metabolic adaptation reactions with relevance for radiation resistance and potential for its therapeutic modulation.

13.10.2020 PD Dr. Adalbert Krawczyk awarded

ZMB member virologist PD Dr. Adalbert Krawczyk has been awarded the Gottschalk-Diederich-Baedeker Prize 2020. This honors his outstanding achievements at the University Hospital Essen for research into the development of a highly effective antibody for the prevention and therapy of Herpex Simplex Virus (HSV) infections.

New Heisenberg Professorship Interlocked molecules as catalysts

[02.12.2020] Not directly connected, but inseparable: Interlocked molecules are interwoven like links in a chain or like a ring on a thread. Dr. Jochen Niemeyer investigates how they are applied. The new Heisenberg professor for organic and supramolecular chemistry is particularly interested in their use as catalysts.

Cooperation UDE / Wuhan One of the most important publications on COVID-19

[18.01.2021] One of the world's most important publications on COVID-19 was written in cooperation with the medical faculty and scientific partners in Wuhan (China). It was published in April 2020 and describes important changes in the immune system of those affected. Eight months later, the relevance of the study becomes apparent: It is one of the most cited publications on the subject worldwide.

Nationwide Network University Medicine Funding for COVID-19 research in Essen approved

[08.01.2021] Clinics and institutes of the University Hospital Essen that collect and analyze disease data and samples from COVID-19 patients are supported by the German Federal Ministry of Education and Research (BMBF) with 895,000€ until the end of this year. The joint goal of the researchers and clinicians is to formulate new research questions and answer existing ones.

DFG funds immune cell study Covid-19: Better understanding of defense cells

[21.12.2020] In a study, researchers from the Faculty of Medicine are investigating the role played by certain immune cells in the fight against SARS-CoV-2 and why some of them last longer than others. Their findings could become particularly important for the treatment and vaccination of the population against COVID-19. The German Research Foundation (DFG) is funding the project for one year with 38,000 euros through a COVID-19 emergency program.

Treatment of blood disorders Immune mechanism discovered

[03.12.2020] Researchers from the Medical Faculty of the UDE and the German Consortium for Translational Cancer Research (DKTK) at the partner location Essen/Düsseldorf have been able to explain a new mechanism in the human immune system. On the basis of their results, new approaches can be studied to improve the therapeutic success of blood stem cell transplants. The German-Dutch study was published in the renowned journal Blood.

SARS-CoV-2 UV light inactivates corona viruses

[01.09.2020] SARS-CoV-2 viruses can be completely inactivated with ultraviolet light. This was shown of Virologyby a promising study by ZMB member PD Dr. Adalbert Krawczyk (photo) and Dr. Christiane Heilingloh from the Institute at the University Hospital Essen. The American Journal of Infection Control is now reporting on this. Their research was funded by the University Medicine Essen Foundation and the Rudolf Ackermann Foundation.

DFG Research Grant for Virkramjeet Singh Feedback loops between gut microbes and immune cells may impact outcome after stroke

[10.06.2020] The DFG approved funding for an exciting new research project of Dr. Vikramjeet Singh that targets at exploring how the interaction with gut microbiota shapes the impact of neutrophils on ischemic brain injury. Singh is principal investigator at the Institute of Experimental Immunology and Imaging at the University Hospital Essen. Working as postdoc at the Institute for Stroke and Dementia Research at the LMU Medical Center, Singh and his colleagues identified a bidirectional communication along the brain–gut microbiota–immune axis and could show that the gut microbiota is a potentially central regulator of immune homeostasis.

Erkenntnisse für Test und Impfstoffe Neue Details der Immunantwort bei Covid-19

[22.05.2020] Das menschliche Immunsystem reagiert auf mehr als nur das bisher fokussierte Virusprotein. Das ist bedeutend für Tests und mögliche Impfstoffe. Forschungsteams der Ruhr-Universität Bochum (RUB) und der Medizinischen Fakultät der UDE am Universitätsklinikums Essen haben herausgefunden, auf welche Teile des Sars-Cov-2-Virus das menschliche Immunsystem reagiert: Neben dem bisher fokussierten Spike-Protein können auch zwei weitere Proteine eine starke Immunantwort auslösen.

Deutsch-chinesische Forschung Schwere COVID-19-Verläufe früh erkennen

[30.04.2020] Viele COVID-19-Erkrankungen verlaufen mild. Aber etwa zehn Prozent der Erkrankten entwickeln eine schwere Lungenentzündung und benötigen intensivmedizinische Versorgung. Um frühzeitig die richtigen therapeutischen Schritte einleiten zu können, ist es wichtig, potentiell gefährdete Patienten zu identifizieren. Gemeinsam mit chinesischen Kollegen am Wuhan Union Hospital haben Wissenschaftler des Instituts für Virologie der Medizinischen Fakultät der UDE festgestellt, dass die T-Zell-Population ein wichtiger Indikator ist. Diese Studie ist jetzt in The Lancet EBiomedicine online veröffentlicht.

Schilddrüse beeinflusst Hirnleistung stärker als gedacht Gut fürs Gedächtnis

[17.04.2020] Schilddrüsenhormone fördern unmittelbar die Bildung von Nervenzellen im Lern- und Gedächtniszentrum des Gehirns. Das belegen Forschungen der Medizinischen Fakultät der UDE und der University of Edinburgh erstmals. Die Ergebnisse liefern neben wichtigen Grundlagenerkenntnissen auch neue Ansatzpunkte, wie die geistige Leistungsfähigkeit mithilfe der Medizin verbessert werden kann. Das renommierte Stem Cell Reports berichtet.

Obermann, Mark; Nägel, Steffen; Ose, Claudia; Sonuc, Nilüfer; Scherag, Andre; Storch, Peter; Gaul, Charly; Böger, Andreas; Kraya, Torsten; Jansen, Jan-Peter; Straube, Andreas; Freilinger, Tobias; Kaube, Holger; Jürgens, Tim P; Diener, Hans Christoph; Katsarava, Zaza; Kleinschnitz, Christoph; Holle, Dagny

Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache : A multicentre, double-blind, randomised controlled trial

In: The Lancet Neurology Vol. 20 (2021) Nr. 1, pp. 29 - 37

ISSN: 1474-4465; 1474-4422

Online Full Text: dx.doi.org/
Schuler, Martin

Corrigendum to “Inhibiting fibroblast growth factor receptors in cancer – The next generation”

In: Annals of Oncology Vol. 32 (2021) Nr. 1, pp. 126

ISSN: 1569-8041; 0923-7534

Online Full Text: dx.doi.org/ (Open Access)
Somasundaram, Rajasekharan; Connelly, Thomas; Choi, Robin; Choi, Hyeree; Samarkina, Anastasia; Li, Ling; Gregorio, Elizabeth; Chen, Yeqing; Thakur, Rohit; Abdel-Mohsen, Mohamed; Beqiri, Marilda; Kiernan, Meaghan; Perego, Michela; Wang, Fang; Xiao, Min; Brafford, Patricia; Yang, Xue; Xu, Xiaowei; Secreto, Anthony; Danet-Desnoyers, Gwenn; Traum, Daniel; Kaestner, Klaus H.; Huang, Alexander C.; Hristova, Denitsa; Wang, Joshua; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Ping-Chen, Fang; Zhou, Xiangyang; Gutierrez, Alexis; Rebecca, Vito W.; Vonteddu, Prashanthi; Dotiwala, Farokh; Bala, Shashi; Majumdar, Sonali; Dweep, Harsh; Wickramasinghe, Jayamanna; Kossenkov, Andrew V.; Reyes-Arbujas, Jorge; Santiago, Kenisha; Nguyen, Tran; Griss, Johannes; Keeney, Frederick; Hayden, James; Gavin, Brian J.; Weiner, David; Montaner, Luis J.; Liu, Qin; Peiffer, Lukas; Becker, Jürgen; Burton, Elizabeth M.; Davies, Michael A.; Tetzlaff, Michael T.; Muthumani, Kar; Wargo, Jennifer A.; Gabrilovich, Dmitry; Herlyn, Meenhard

Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy

In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 346

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Singh, Priyanka; Pesenti, Marion E.; Maffini, Stefano; Carmignani, Sara; Hedtfeld, Marius; Petrovic, Arsen; Srinivasamani, Anupallavi; Bange, Tanja; Musacchio, Andrea

BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis

In: Molecular Cell Vol. 81 (2021) Nr. 1, pp. 67 - 87.e9

ISSN: 1097-4164; 1097-2765

Online Full Text: dx.doi.org/ (Open Access)

All selected publications

ZMB Research Programs

Oncology

The concept of this research program is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments.

Participating researchers from biology, experimental and clinical medicine study tumors as “biological systems" and so called “neo-organs”.

A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.

Immunology, Infectious Diseases and Transplantation

The immune system responds to various pathogens including viruses and bacteria in different ways to prevent severe disease and persistence in the host. Many pathogens, however, have developed mechanisms to evade immune defence.

The molecular and cellular interactions of pathogens with the immune system are studied within this program.

Molecular and Chemical Cell Biology

Molecular and chemical cell biology is an interdisciplinary research program connecting molecular cell biology and genetics with chemistry and structural biology. Scientists of the participating disciplines collaborate to advance the understanding of basic molecular mechanisms of important biological processes.

The analysis of regulation and deregulation of key pathways is linking basic biology with pathophysiology.

Journal articles

Chuang, Chen-Hua; Dorsch, Madeleine; Dujardin, Philip; Silas, Sukrit; Ueffing, Kristina; Hölken, Johanna M; Yang, Dian; Winslow, Monte M.; Grüner, Barbara M.

Altered mitochondria functionality defines a metastatic cell state in lung cancer and creates an exploitable vulnerability

In: Cancer Research Vol. 81 (2021) Nr. 3,

ISSN: 0008-5472; 1538-7445

Online Full Text: dx.doi.org/
Singh, Priyanka; Pesenti, Marion E.; Maffini, Stefano; Carmignani, Sara; Hedtfeld, Marius; Petrovic, Arsen; Srinivasamani, Anupallavi; Bange, Tanja; Musacchio, Andrea

BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis

In: Molecular Cell Vol. 81 (2021) Nr. 1, pp. 67 - 87.e9

ISSN: 1097-4164; 1097-2765

Online Full Text: dx.doi.org/ (Open Access)
Piano, Valentina; Alex, Amal; Stege, Patricia; Maffini, Stefano; Stoppiello, Gerardo A.; Huis In'T Veld, Pim J.; Vetter, Ingrid R.; Musacchio, Andrea

CDC20 assists its catalytic incorporation in the mitotic checkpoint complex

In: Science Vol. 371 (2021) Nr. 6524, pp. 67 - 71

ISSN: 1095-9203; 0036-8075

Online Full Text: dx.doi.org/
Schuler, Martin

Corrigendum to “Inhibiting fibroblast growth factor receptors in cancer – The next generation”

In: Annals of Oncology Vol. 32 (2021) Nr. 1, pp. 126

ISSN: 1569-8041; 0923-7534

Online Full Text: dx.doi.org/ (Open Access)
Kunzmann, Volker; Siveke, Jens; Algül, Hana; Goekkurt, Eray; Siegler, Gabriele; Martens, Uwe; Waldschmidt, Dirk; Pelzer, Uwe; Fuchs, Martin; Kullmann, Frank; Boeck, Stefan; Ettrich, Thomas J; Held, Swantje; Keller, Ralph; Klein, Ingo; Germer, Christoph-Thomas; Stein, Hubert; Friess, Helmut; Bahra, Marcus; Jakobs, Ralf; Hartlapp, Ingo; Heinemann, Volker; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators; Stahl, Michael; Mahlmann, Stefan

Nab-paclitaxel plus gemcitabine versus nab-paclitaxel plus gemcitabine followed by FOLFIRINOX induction chemotherapy in locally advanced pancreatic cancer (NEOLAP-AIO-PAK-0113) : a multicentre, randomised, phase 2 trial

In: The Lancet Gastroenterology & Hepatology Vol. 6 (2021) Nr. 2, pp. 128 - 138

ISSN: 2468-1253

Online Full Text: dx.doi.org/
Heming, Michael; Li, Xiaolin; Räuber, Saskia; Mausberg, Anne K.; Börsch, Anna-Lena; Hartlehnert, Maike; Singhal, Arpita; Lu, I-Na; Fleischer, Michael; Szepanowski, Fabian; Witzke, Oliver; Brenner, Thorsten; Dittmer, Ulf; Yosef, Nir; Kleinschnitz, Christoph; Wiendl, Heinz; Stettner, Mark; Meyer zu Hörste, Gerd

Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid

In: Immunity Vol. 54 (2021) Nr. 1, pp. 164

ISSN: 1097-4180; 1074-7613

Online Full Text: dx.doi.org/ (Open Access)
Mueller, Franziska; Friese, Alexandra; Pathe, Claudio; da Silva, Richard Cardoso; Bravo Rodriguez, Kenny; Musacchio, Andrea; Bange, Tanja

Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization

In: Science Advances Vol. 7 (2021) Nr. 3, pp. eabc8590

ISSN: 2375-2548

Online Full Text: dx.doi.org/ (Open Access)
Obermann, Mark; Nägel, Steffen; Ose, Claudia; Sonuc, Nilüfer; Scherag, Andre; Storch, Peter; Gaul, Charly; Böger, Andreas; Kraya, Torsten; Jansen, Jan-Peter; Straube, Andreas; Freilinger, Tobias; Kaube, Holger; Jürgens, Tim P; Diener, Hans Christoph; Katsarava, Zaza; Kleinschnitz, Christoph; Holle, Dagny

Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache : A multicentre, double-blind, randomised controlled trial

In: The Lancet Neurology Vol. 20 (2021) Nr. 1, pp. 29 - 37

ISSN: 1474-4465; 1474-4422

Online Full Text: dx.doi.org/
Lee, Jung-Hoon; Bollschweiler, Daniel; Schäfer, Tillman; Huber, Robert

Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies

In: Science Advances Vol. 7 (2021) Nr. 2, pp. eabd4413

ISSN: 2375-2548

Online Full Text: dx.doi.org/ (Open Access)
Somasundaram, Rajasekharan; Connelly, Thomas; Choi, Robin; Choi, Hyeree; Samarkina, Anastasia; Li, Ling; Gregorio, Elizabeth; Chen, Yeqing; Thakur, Rohit; Abdel-Mohsen, Mohamed; Beqiri, Marilda; Kiernan, Meaghan; Perego, Michela; Wang, Fang; Xiao, Min; Brafford, Patricia; Yang, Xue; Xu, Xiaowei; Secreto, Anthony; Danet-Desnoyers, Gwenn; Traum, Daniel; Kaestner, Klaus H.; Huang, Alexander C.; Hristova, Denitsa; Wang, Joshua; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Ping-Chen, Fang; Zhou, Xiangyang; Gutierrez, Alexis; Rebecca, Vito W.; Vonteddu, Prashanthi; Dotiwala, Farokh; Bala, Shashi; Majumdar, Sonali; Dweep, Harsh; Wickramasinghe, Jayamanna; Kossenkov, Andrew V.; Reyes-Arbujas, Jorge; Santiago, Kenisha; Nguyen, Tran; Griss, Johannes; Keeney, Frederick; Hayden, James; Gavin, Brian J.; Weiner, David; Montaner, Luis J.; Liu, Qin; Peiffer, Lukas; Becker, Jürgen; Burton, Elizabeth M.; Davies, Michael A.; Tetzlaff, Michael T.; Muthumani, Kar; Wargo, Jennifer A.; Gabrilovich, Dmitry; Herlyn, Meenhard

Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy

In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 346

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)

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Selected Publications 2020

Journal articles

Gigante, Alba; Sijbesma, Eline; Sánchez-Murcia, Pedro A.; Hu, Xiaoyu; Bier, David; Bäcker, Sandra; Knauer, Shirley; Gago, Federico; Ottmann, Christian; Schmuck, Carsten

A Supramolecular Stabilizer of the 14-3-3ζ/ERα Protein-Protein Interaction with a Synergistic Mode of Action

In: Angewandte Chemie International Edition Vol. 132 (2020) Nr. 13, pp. 5322 - 5325

ISSN: 1521-3773; 1433-7851; 0570-0833

Online Full Text: dx.doi.org/ (Open Access)
Dykun, Iryna; Mahabadi, Amir Abbas; Rassaf, Tienush

A clinical perspective on the 2019 ESC/EAS guidelines for the management of dyslipidaemias: PCSK-9 inhibitors for all?

In: European Heart Journal Vol. 41 (2020) Nr. 24, pp. 2331

ISSN: 1522-9645

Online Full Text: dx.doi.org/
Shen, Lu; Kohlhaas, Martha; Enoki, Junichi; Meier, Roland; Schönenberger, Bernhard; Wohlgemuth, Roland; Kourist, Robert; Niemeyer, Felix; van Niekerk, David; Bräsen, Christopher; Niemeyer, Jochen; Snoep, Jacky; Siebers, Bettina

A combined experimental and modelling approach for the Weimberg pathway optimisation

In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 1098

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Lang, Judith; Bohn, Patrick; Bhat, Hilal; Jastrow, Holger; Walkenfort, Bernd; Cansiz, Feyza; Fink, Julian; Bauer, Michael; Olszewski, Dominik; Ramos-Nascimento, Ana; Duhan, Vikas; Friedrich, Sarah-Kim; Becker-Flegler, Katrin; Krawczyk, Adalbert; Edwards, Michael J.; Burchert, Andreas; Huber, Magdalena; Friebus-Kardash, Justa; Göthert, Joachim Rudolf; Hardt, Cornelia; Probst, Hans Christian; Schumacher, Fabian; Köhrer, Karl; Kleuser, Burkhard; Babiychuk, Eduard B.; Sodeik, Beate; Seibel, Jürgen; Greber, Urs F.; Lang, Philipp A.; Gulbins, Erich; Lang, Karl S.

Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 1338

ISSN: 2041-1723

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Dummer, Reinhard; Brase, Jan C.; Garrett, James; Campbell, Catarina D.; Gasal, Eduard; Squires, Matthew; Gusenleitner, Daniel; Santinami, Mario; Atkinson, Victoria; Mandalà, Mario; Chiarion-Sileni, Vanna; Flaherty, Keith; Larkin, James; Robert, Caroline; Kefford, Richard; Kirkwood, John M.; Hauschild, Axel; Schadendorf, Dirk; Long, Georgina V.

Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAFV⁶⁰⁰-mutant, stage III melanoma (COMBI-AD) : Exploratory biomarker analyses from a randomised, phase 3 trial

In: The Lancet Oncology Vol. 21 (2020) Nr. 3, pp. 358 - 372

ISSN: 1474-5488; 1470-2045

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Zimmer, Lisa; Livingstone, Elisabeth; Hassel, Jessica C.; Fluck, Michael; Eigentler, Thomas; Loquai, Carmen; Haferkamp, Sebastian; Gutzmer, Ralf; Meier, Friedegund; Mohr, Peter; Hauschild, Axel; Schilling, Bastian; Menzer, Christian; Kieker, Felix; Dippel, Edgar; Rösch, Alexander; Simon, Jan-Christoph; Conrad, Beate; Körner, Silvia; Windemuth-Kieselbach, Christine; Schwarz, Leonora; Garbe, Claus; Becker, Jürgen C.; Schadendorf, Dirk; Berking, Carola; Herbst, Rudolf A.; Martens, Uwe M; Sell, Sabine; Stadler, Rudolf; Terheyden, Patrick; Utikal, Jochen

Adjuvant nivolumab plus ipilimumab or nivolumab monotherapy versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED) : a randomised, double-blind, placebo-controlled, phase 2 trial

In: The Lancet Vol. 395 (2020) Nr. 10236, pp. 1558 - 1568

ISSN: 1474-547X; 0140-6736

Online Full Text: dx.doi.org/
Eggermont, Alexander M. M.; Kicinski, Michal; Blank, Christian U.; Mandala, Mario; Long, Georgina V.; Atkinson, Victoria; Dalle, Stéphane; Haydon, Andrew; Khattak, Adnan; Carlino, Matteo S.; Sandhu, Shahneen; Larkin, James; Puig, Susana; Ascierto, Paolo A.; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Di Giacomo, Anna Maria; Van Den Eertwegh, Alfonsus J. M.; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; Lorigan, Paul C.; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Van Akkooi, Alexander; Robert, Caroline; Suciu, Stefan

Association between Immune-Related Adverse Events and Recurrence-Free Survival among Patients with Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo : A Secondary Analysis of a Randomized Clinical Trial

In: JAMA Oncology Vol. 6 (2020) Nr. 4, pp. 519 - 527

ISSN: 2374-2445; 2374-2437

Online Full Text: dx.doi.org/ (Open Access)
Puzanov, Igor; Ribas, Antoni; Robert, Caroline; Schachter, Jacob; Nyakas, Marta; Daud, Adil; Arance, Ana; Carlino, Matteo S.; O'Day, Steven J.; Long, Georgina V.; Margolin, Kim A.; Dummer, Reinhard; Schadendorf, Dirk; Lutzky, Jose; Ascierto, Paolo A.; Tarhini, Ahmad; Lin, Jianxin; Mogg, Robin; Homet Moreno, Blanca; Ibrahim, Nageatte; Hamid, Omid

Association of BRAF V600E/K Mutation Status and Prior BRAF/MEK Inhibition with Pembrolizumab Outcomes in Advanced Melanoma : Pooled Analysis of 3 Clinical Trials

In: JAMA Oncology Vol. 6 (2020) Nr. 8, pp. 1256 - 1264

ISSN: 2374-2445; 2374-2437

Online Full Text: dx.doi.org/
Liu, David; Schilling, Bastian; Liu, Derek; Sucker, Antje; Livingstone, Elisabeth; Jerby-Arnon, Livnat; Zimmer, Lisa; Gutzmer, Ralf; Satzger, Imke; Loquai, Carmen; Grabbe, Stephan; Vokes, Natalie; Margolis, Claire A.; Conway, Jake; He, Meng Xiao; Elmarakeby, Haitham; Dietlein, Felix; Miao, Diana; Tracy, Adam; Gogas, Helen; Goldinger, Simone M.; Utikal, Jochen; Blank, Christian U.; Rauschenberg, Ricarda; von Bubnoff, Dagmar; Krackhardt, Angela; Weide, Benjamin; Haferkamp, Sebastian; Kiecker, Felix; Izar, Ben; Garraway, Levi; Regev, Aviv; Flaherty, Keith; Paschen, Annette; Van Allen, Eliezer M.; Schadendorf, Dirk

Author Correction: Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

In: Nature Medicine Vol. 26 (2020) Nr. 7, pp. 1147

ISSN: 1546-170X; 1078-8956

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk

Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 6232

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Cabrita, Rita; Lauss, Martin; Sanna, Adriana; Donia, Marco; Skaarup Larsen, Mathilde; Mitra, Shamik; Johansson, Iva; Phung, Bengt; Harbst, Katja; Vallon-Christersson, Johan; van Schoiack, Alison; Lövgren, Kristina; Warren, Sarah; Jirström, Karin; Olsson, Håkan; Pietras, Kristian; Ingvar, Christian; Isaksson, Karolin; Schadendorf, Dirk; Schmidt, Henrik; Bastholt, Lars; Carneiro, Ana; Wargo, Jennifer A.; Svane, Inge Marie; Jönsson, Göran

Author Correction: Tertiary lymphoid structures improve immunotherapy and survival in melanoma

In: Nature Vol. 580 (2020) Nr. 7801, pp. E1

ISSN: 1476-4687; 0028-0836

Online Full Text: dx.doi.org/
Killinger, Kerstin; Böhm, Miriam; Steinbach, Philine; Hagemann, Götz; Blüggel, Mike; Jänen, Karolin; Hohoff, Simone; Bayer, Peter; Herzog, Franz; Westermann, Stefan

Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeast

In: The EMBO Journal Vol. 39 (2020) Nr. 14, pp. e102938

ISSN: 1460-2075; 0261-4189

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Heinrich, Michael C.; Jones, Robin L.; von Mehren, Margaret; Schöffski, Patrick; Serrano, César; Kang, Yoon-Koo; Cassier, Philippe A.; Mir, Olivier; Eskens, Ferry; Tap, William D.; Rutkowski, Piotr; Chawla, Sant P.; Trent, Jonathan; Tugnait, Meera; Evans, Erica K.; Lauz, Tamieka; Zhou, Teresa; Roche, Maria; Wolf, Beni B.; Bauer, Sebastian; George, Suzanne

Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR) : A multicentre, open-label, phase 1 trial

In: The Lancet Oncology Vol. 21 (2020) Nr. 7, pp. 935 - 946

ISSN: 1474-5488; 1470-2045

Online Full Text: dx.doi.org/
Wang, Huichen; Perrault, Ange Ronel; Takeda, Yoshihiko; Qin, Wei; Wang, Hongyan; Iliakis, George

Biochemical evidence for Ku-independent backup pathways of NHEJ

In: Nucleic Acids Research Vol. 48 (2020) Nr. 9, pp. 5200

ISSN: 1362-4962; 0301-5610; 0305-1048

Online Full Text: dx.doi.org/ (Open Access)
Bengoa-Vergniory, Nora; Faggiani, Emilie; Ramos-Gonzalez, Paula; Kirkiz, Ecem; Connor-Robson, Natalie; Brown, Liam V.; Siddique, Ibrar; Li, Zizheng; Vingill, Siv; Cioroch, Milena; Cavaliere, Fabio; Threlfell, Sarah; Roberts, Bradley; Schrader, Thomas; Klärner, Frank-Gerrit; Cragg, Stephanie; Dehay, Benjamin; Bitan, Gal; Matute, Carlos; Bezard, Erwan; Wade-Martins, Richard

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease

In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4885

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Grüner, Barbara M.; Fendt, Sarah-Maria

Cancer cells stock up in lymph vessels to survive

In: Nature Vol. 585 (2020) Nr. 7823, pp. 36 - 37

ISSN: 1476-4687; 0028-0836

Online Full Text: dx.doi.org/
Brenner, Ellen; Schörg, Barbara F.; Ahmetlić, Fatima; Wieder, Thomas; Hilke, Franz Joachim; Simon, Nadine; Schroeder, Christopher; Demidov, German; Riedel, Tanja; Fehrenbacher, Birgit; Schaller, Martin; Forschner, Andrea; Eigentler, Thomas; Niessner, Heike; Sinnberg, Tobias; Böhm, Katharina S.; Hömberg, Nadine; Braumüller, Heidi; Dauch, Daniel; Zwirner, Stefan; Zender, Lars; Sonanini, Dominik; Geishauser, Albert; Bauer, Jürgen; Eichner, Martin; Jarick, Katja J.; Beilhack, Andreas; Biskup, Saskia; Döcker, Dennis; Schadendorf, Dirk; Quintanilla-Martinez, Leticia; Pichler, Bernd J.; Kneilling, Manfred; Mocikat, Ralph; Röcken, Martin

Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours

In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 1335

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
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Cardiac fibroblast activation detected by positron emission tomography/computed tomography as a possible sign of cardiotoxicity

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Cemiplimab in locally advanced cutaneous squamous cell carcinoma : results from an open-label, phase 2, single-arm trial

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Co-option of Neutrophil Fates by Tissue Environments

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Combined PD-1, BRAF and MEK inhibition in advanced BRAF-mutant melanoma : safety run-in and biomarker cohorts of COMBI-i

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Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality

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Corrigendum to “Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics” [Biomaterials 192 (2019) 551–559]

In: Biomaterials Vol. 263 (2020) pp. 120371

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Durable and controlled depletion of neutrophils in mice

In: Nature Communications Vol. 11 (2020) pp. 2762

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Elevated baseline serum PD-1 or PD-L1 predicts poor outcome of PD-1 inhibition therapy in metastatic melanoma

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External validation of models for KIR2DS1/KIR3DL1-informed selection of hematopoietic cell donors fails

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Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury

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From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins : the chemical biology of Ahp-cyclodepsipeptides

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Functional Disruption of the Cancer-Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole Ligand

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Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

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Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes

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Heterobifunctional Rotaxanes for Asymmetric Catalysis

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Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK Pathway

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Inhibition of haspin kinase promotes cell-intrinsic and extrinsic antitumor activity

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Integrated molecular drivers coordinate biological and clinical states in melanoma

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Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation

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Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 3547

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Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma

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Metabolic heterogeneity confers differences in melanoma metastatic potential

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Molecular correlates of response to capmatinib in advanced non-small-cell lung cancer : Clinical and biomarker results from a phase I trial

In: Annals of Oncology (2020)

ISSN: 1569-8041; 0923-7534

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Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations

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Non-classical monocyte homing to the gut via α4β7 integrin mediates macrophage-dependent intestinal wound healing

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Nusinersen in adults with 5q spinal muscular atrophy : A non-interventional, multicentre, observational cohort study

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PD-1 Blockade in Anaplastic Thyroid Carcinoma

In: Journal of Clinical Oncology Vol. 38 (2020) Nr. 23, pp. 2620 - 2627

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Pan-cancer analysis of whole genomes

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Peptide and peptide-based inhibitors of SARS-CoV-2 entry

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Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM

In: Blood (2020) in press

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Post-transplantation cyclophosphamide GvHD prophylaxis after hematopoietic stem cell transplantation from 9/10 or 10/10 HLA-matched unrelated donors for acute leukemia

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Predominance of Central Memory T Cells with High T-Cell Receptor Repertoire Diversity is Associated with Response to PD-1/PD-L1 Inhibition in Merkel Cell Carcinoma

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Present and Future of Surface-Enhanced Raman Scattering

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Prognosis of patients with stage III melanoma according to American joint committee on cancer version 8 : A reassessment on the basis of 3 independent stage III melanoma cohorts

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Prognostic impact of baseline tumour immune infiltrate on disease-free survival in patients with completely resected, BRAFv⁶⁰⁰ mutation–positive melanoma receiving adjuvant vemurafenib

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Online Full Text: dx.doi.org/
Heinrich, Michael C.; George, Suzanne; Zalcberg, John Raymond; Bauer, Sebastian; Gelderblom, Hans; Schoffski, Patrick; Serrano, Cesar; Jones, Robin L.; Attia, Steven; D'Amato, Gina Z.; Chi, Ping; Reichardt, Peter; Becker, Claus C.; Meade, Julie Nicole; Ruiz-Soto, Rodrigo; von Mehren, Margaret; Blay, Jean-Yves

Quality of life (QoL) and self-reported function with ripretinib in ≥4th-line therapy for patients with gastrointestinal stromal tumors (GIST) : Analyses from INVICTUS

In: Journal of Clinical Oncology Vol. 38 (2020) Nr. 15_Suppl., pp. 11535

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Grünwald, Viktor; Karch, Annika; Schuler, Markus; Schöffski, Patrick; Kopp, Hans-Georg; Bauer, Sebastian; Kasper, Bernd; Lindner, Lars H.; Chemnitz, Jens-Marcus; Crysandt, Martina; Stein, Alexander; Steffen, Björn; Richter, Stephan; Egerer, Gerlinde; Ivanyi, Philipp; Zimmermann, Silke; Liu, Xiaofei; Kunitz, Annegret

Randomized Comparison of Pazopanib and Doxorubicin as First-Line Treatment in Patients with Metastatic Soft Tissue Sarcoma Age 60 Years or Older : Results of a German Intergroup Study

In: Journal of Clinical Oncology Vol. 38 (2020) Nr. 30, pp. 3555 - 3564

ISSN: 1527-7755; 0732-183X

Online Full Text: dx.doi.org/
Dummer, Reinhard; Ascierto, Paolo A.; Nathan, Paul; Robert, Caroline; Schadendorf, Dirk

Rationale for Immune Checkpoint Inhibitors plus Targeted Therapy in Metastatic Melanoma : A Review

In: JAMA Oncology (2020) in press

ISSN: 2374-2445; 2374-2437

Online Full Text: dx.doi.org/
Hermann, Dirk M.; Bassetti, Claudio L.; Marx, Ute; Audoli-Inthavong, Marie-Laure; Chabriat, Hugues

Refining endpoints for stroke recovery trials

In: The Lancet Neurology Vol. 19 (2020) Nr. 5, pp. 381 - 382

ISSN: 1474-4465; 1474-4422

Online Full Text: dx.doi.org/
Küppers, Ralf; Schadendorf, Dirk

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4748

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Blay, Jean-Yves; Serrano, César; Heinrich, Michael C.; Zalcberg, John; Bauer, Sebastian; Gelderblom, Hans; Schöffski, Patrick; Jones, Robin L; Attia, Steven; D'Amato, Gina; Chi, Ping; Reichardt, Peter; Meade, Julie; Shi, Kelvin; Ruiz-Soto, Rodrigo; George, Suzanne; von Mehren, Margaret

Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS) : a double-blind, randomised, placebo-controlled, phase 3 trial

In: The Lancet Oncology Vol. 21 (2020) Nr. 7, pp. 923 - 934

ISSN: 1474-5488; 1470-2045

Online Full Text: dx.doi.org/
Petersdorf, Effie W.; Bengtsson, Mats; De Santis, Dianne; Dubois, Valerie; Fleischhauer, Katharina; Gooley, Ted; Horowitz, Mary; Madrigal, J Alejandro; Malkki, Mari; McKallor, Caroline; Morishima, Yasuo; Oudshoorn, Machteld; Spellman, Stephen R.; Villard, Jean; Stevenson, Phil; Carrington, Mary

Role of HLA-DP Expression in Graft-Versus-Host Disease After Unrelated Donor Transplantation

In: Journal of Clinical Oncology Vol. 38 (2020) Nr. 24, pp. 2712 - 2718

ISSN: 1527-7755; 0732-183X

Online Full Text: dx.doi.org/
Heichler, Christina; Scheibe, Kristina; Schmied, Anabel; Geppert, Carol I; Schmid, Benjamin; Wirtz, Stefan; Thoma, Oana-Maria; Kramer, Viktoria; Waldner, Maximilian J; Büttner, Christian; Farin, Henner; Pešić, Marina; Knieling, Ferdinand; Merkel, Susanne; Grüneboom, Anika; Gunzer, Matthias; Grützmann, Robert; Rose-John, Stefan; Koralov, Sergei; Kollias, George; Vieth, Michael; Hartmann, Arndt; Greten, Florian; Neurath, Markus F; Neufert, Clemens

STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis

In: Gut Vol. 69 (2020) Nr. 7, pp. 1269 - 1282

ISSN: 0017-5749

Online Full Text: dx.doi.org/
Bazinet, Michel; Pântea, Victor; Placinta, Gheorghe; Moscalu, Iurie; Cebotarescu, Valentin; Cojuhari, Lilia; Jimbei, Pavlina; Iarovoi, Liviu; Smesnoi, Valentina; Musteata, Tatiana; Jucov, Alina; Dittmer, Ulf; Krawczyk, Adalbert; Vaillant, Andrew

Safety and Efficacy of 48 Weeks REP 2139 or REP 2165, Tenofovir Disoproxil, and Pegylated Interferon Alfa-2a in Patients With Chronic HBV Infection Naïve to Nucleos(t)ide Therapy

In: Gastroenterology Vol. 158 (2020) Nr. 8, pp. 2180 - 2194

ISSN: 1528-0012; 0016-5085

Online Full Text: dx.doi.org/
Chabriat, Hugues; Bassetti, Claudio L; Marx, Ute; Audoli-Inthavong, Marie-Laure; Sors, Aurore; Lambert, Estelle; Wattez, Marine; Hermann, Dirk M.; Diener, Hans Christoph; Restore Brain Study Investigators

Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke : A multicentre, double-blind, randomised, placebo-controlled trial

In: The Lancet Neurology Vol. 19 (2020) Nr. 3, pp. 226 - 233

ISSN: 1474-4465; 1474-4422

Online Full Text: dx.doi.org/
George, Suzanne; Heinrich, Michael C.; Zalcberg, John Raymond; Bauer, Sebastian; Gelderblom, Hans; Schoffski, Patrick; Serrano, Cesar; Jones, Robin L.; Attia, Steven; D'Amato, Gina Z.; Chi, Ping; Reichardt, Peter; Lacouture, Mario E.; Cha, Elva; Meade, Julie Nicole; Ruiz-Soto, Rodrigo; Blay, Jean-Yves; von Mehren, Margaret

Safety profile of ripretinib, including impact of alopecia, and Palmar-Plantar Erythrodysesthesia Syndrome (PPES) on patient-reported outcomes (PROs), in ≥ fourth-line advanced gastrointestinal stromal tumors (GIST) : Analyses from INVICTUS

In: Journal of Clinical Oncology Vol. 38 (2020) Nr. 15_Suppl., pp. 11539

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Küppers, Ralf; Schadendorf, Dirk; PCAWG Tumour Subtypes and Clinical Translation; PCAWG Consortium

Sex differences in oncogenic mutational processes

In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4330

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Mladenov, Emil; Staudt, Christian; Soni, Aashish; Murmann-Konda, Tamara; Siemann-Loekes, Maria; Iliakis, George

Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52

In: Nucleic Acids Research Vol. 48 (2020) Nr. 4, pp. 1905 - 1924

ISSN: 1362-4962; 0305-1048

Online Full Text: dx.doi.org/ (Open Access)
Sijbesma, Eline; Visser, Emira; Plitzko, Kathrin; Thiel, Philipp; Milroy, Lech-Gustav; Kaiser, Markus; Brunsveld, Luc; Ottmann, Christian

Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions

In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 3954

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Cabrita, Rita; Lauss, Martin; Sanna, Adriana; Donia, Marco; Larsen, Mathilde; Schadendorf, Dirk

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

In: Nature Vol. 577 (2020) Nr. 7791, pp. 561 - 565

ISSN: 0028-0836; 1476-4687

Online Full Text: dx.doi.org/
Schuler, Martin

The quest for efficient trial designs in precision oncology

In: The Lancet Oncology Vol. 21 (2020) Nr. 12, pp. 1539 - 1541

ISSN: 1474-5488; 1470-2045

Online Full Text: dx.doi.org/
Bell, Steven E. J.; Charron, Gaëlle; Cortés, Emiliano; Kneipp, Janina; de la Chapelle, Marc Lamy; Langer, Judith; Procházka, Marek; Tran, Vi; Schlücker, Sebastian

Towards Reliable and Quantitative Surface-Enhanced Raman Scattering (SERS) : From Key Parameters to Good Analytical Practice

In: Angewandte Chemie International Edition Vol. 59 (2020) pp. 5454 - 5462

ISSN: 1521-3773; 1433-7851

Online Full Text: dx.doi.org/ (Open Access)
Gremke, Niklas; Polo, Pierfrancesco; Dort, Aaron; Schneikert, Jean; Elmshäuser, Sabrina; Brehm, Corinna; Klingmüller, Ursula; Schmitt, Anna; Reinhardt, Hans Christian; Timofeev, Oleg; Wanzel, Michael; Stiewe, Thorsten

mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4684

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)

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Selected Publications 2019

Journal articles

Wang, Kun; Sybers, David; Maklad, Hassan Ramadan; Lemmens, Liesbeth; Lewyllie, Charlotte; Zhou, Xiaoxiao; Schult, Frank; Bräsen, Christopher; Siebers, Bettina; Valegård, Karin; Lindås, Ann-Christin; Peeters, Eveline

A TetR-family transcription factor regulates fatty acid metabolism in the archaeal model organism Sulfolobus acidocaldarius

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1542

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Türeci, Özlem; Sahin, Ugur; Schulze-Bergkamen, Henning; Zvirbule, Zanete; Lordick, Florian; Koeberle, Dieter; Thuss-Patience, Peter C.; Ettrich, Thomas J.; Arnold, Dirk; Bassermann, Florian; Al-Batran, Salah Eddin; Wiechen, K.; Dhaene, Karl F. L.; Maurus, D.; Gold, M.; Huber, Christopher H.; Krivoshik, Andrew P.; Arozullah, A.; Park, J. W.; Schuler, Martin

A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus : the MONO study

In: Annals of Oncology Vol. 30 (2019) Nr. 9, pp. 1487 - 1495

ISSN: 1569-8041; 0923-7534

Online Full Text: dx.doi.org/ (Open Access)
Wülling, Manuela; Vortkamp, Andrea

A newly discovered stem cell that keeps bones growing

In: Nature Vol. 567 (2019) Nr. 7747, pp. 178 - 179

ISSN: 0028-0836; 1476-4687

Online Full Text: dx.doi.org/
Taylor, Matthew H.; Gainor, Justin F.; Hu, Mimi I-Nan; Zhu, Viola Weijia; Lopes, Gilberto; Leboulleux, Sophie; Brose, Marcia S.; Schuler, Martin; Bowles, Daniel W.; Kim, Dong-Wan; Baik, Christina S; Garralda, Elena; Lin, Chia-Chi; Adkins, Douglas; Sarker, Debashis; Curigliano, Giuseppe; Zhang, Hui; Clifford, Corinne; Turner, Christopher D.; Subbiah, Vivek

Activity and tolerability of BLU-667, a highly potent and selective RET inhibitor, in patients with advanced RET-altered thyroid cancers

In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15_Suppl, pp. 6018

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Juric, Dejan; Janku, Filip; Rodón, Jordi; Burris, Howard A.; Mayer, Ingrid A.; Schuler, Martin; Seggewiss-Bernhardt, Ruth; Gil-Martin, Marta; Middleton, Mark R.; Baselga, José; Bootle, Douglas; Demanse, David; Blumenstein, Lars; Schumacher, Karl; Huang, Alan; Quadt, Cornelia; Rugo, Hope S.

Alpelisib Plus Fulvestrant in PIK3CA -Altered and PIK3CA -Wild-Type Estrogen Receptor-Positive Advanced Breast Cancer : A Phase 1b Clinical Trial

In: JAMA Oncology Vol. 5 (2019) Nr. 2, pp. e184475

ISSN: 2374-2445; 2374-2437

Online Full Text: dx.doi.org/
Lindahl, Lise M.; Willerslev-Olsen, Andreas; Gjerdrum, Lise M.R.; Nielsen, Pia R.; Blümel, Edda; Rittig, Anne H.; Celis, Pamela; Herpers, Bjorn; Becker, Jürgen; Stausbøl-Grøn, Birgitte; Wasik, Mariusz A.; Gluud, Maria; Fredholm, Simon; Buus, Terkild B.; Johansen, Claus; Nastasi, Claudia; Peiffer, Lukas; Kubat, Linda; Bzorek, Michael; Eriksen, Jens O.; Krejsgaard, Thorbjørn; Bonefeld, Charlotte M.; Geisler, Carsten; Mustelin, Tomas; Langhoff, Erik; Givskov, Michael; Woetmann, Anders; Kilian, Mogens; Litman, Thomas; Iversen, Lars; Odum, Niels

Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma

In: Blood Vol. 134 (2019) Nr. 13, pp. 1072 - 1083

ISSN: 1528-0020; 0006-4971

Online Full Text: dx.doi.org/
Siemer, Svenja; Westmeier, Dana; Barz, Matthias; Eckrich, Jonas; Wünsch, Désirée; Seckert, Christof; Thyssen, Christian; Schilling, Oliver; Hasenberg, Mike; Pang, Chengfan; Docter, Dominic; Knauer, Shirley K.; Stauber, Roland H.; Strieth, Sebastian

Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing : Implications for the design of improved nanoantibiotics

In: Biomaterials Vol. 192 (2019) pp. 551 - 559

ISSN: 0142-9612; 1878-5905

Online Full Text: dx.doi.org/
Mai, Elias K.; Hielscher, Thomas; Bertsch, Uta; Schlenzka, Jana; Salwender, Hans J.; Munder, Markus; Gerecke, Christian; Dührsen, Ulrich; Brossart, Peter; Neben, Kai; Hillengass, Jens; Raab, Marc S.; Merz, Maximilian; Baertsch, Marc-Andrea; Jauch, Anna; Hose, Dirk; Martin, Hans; Lindemann, Hans-Walter; Blau, Igor W.; Scheid, Christof; Weisel, Katja C.; Goldschmidt, Hartmut

Bortezomib-based induction therapy with high or low-dose dexamethasone in newly diagnosed, transplant-eligible multiple myeloma

In: Leukemia Vol. 33 (2019) Nr. 7, pp. 258 - 261

ISSN: 0887-6924; 1476-5551

Online Full Text: dx.doi.org/
Dmitrieva-Posocco, Oxana; Dzutsev, Amiran; Posocco, David F.; Hou, Vivianty; Yuan, Wuxing; Thovarai, Vishal; Mufazalov, Ilgiz A.; Gunzer, Matthias; Shilovskiy, Igor P.; Khaitov, Musa R.; Trinchieri, Giorgio; Waisman, Ari; Grivennikov, Sergei I.

Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer

In: Immunity Vol. 50 (2019) Nr. 1, pp. 166 - 180.e7

ISSN: 1097-4180; 1074-7613

Online Full Text: dx.doi.org/ (Open Access)
Syeda, Mahrukh M; WIGGINS, JENNIFER M; Corless, Broderick; Long, Georgina V.; Flaherty, Keith; Schadendorf, Dirk; Nathan, Paul D.; Robert, Caroline; Ribas, Antoni; Davies, Michael A.; Grob, Jean Jacques; Gasal, Eduard; Squires, Matthew; Marker, Mahtab; Brase, Jan C.; Polsky, David

Circulating tumor DNA (ctDNA) kinetics to predict survival in patients (pts) with unresectable or metastatic melanoma treated with dabrafenib (D) or D + trametinib (T)

In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15_suppl, pp. 9510

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Merz, Simon F.; Korste, Sebastian; Bornemann, Lea; Michel, Lars; Stock, Pia; Squire, Anthony; Soun, Camille; Engel, Daniel Robert; Detzer, Julia; Lörchner, Holger; Hermann, Dirk M.; Kamler, Markus; Klode, Joachim; Hendgen-Cotta, Ulrike B.; Rassaf, Tienush; Gunzer, Matthias; Totzeck, Matthias

Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2312

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Smith, Nikaïa; Rodero, Mathieu P.; Bekaddour, Nassima; Bondet, Vincent; Ruiz-Blanco, Yasser B.; Harms, Mirja; Mayer, Benjamin; Badder-Meunier, Brigitte; Quartier, Pierre; Bodemer, Christine; Baudouin, Véronique; Dieudonné, Yannick; Kirchhoff, Frank; Sanchez-Garcia, Elsa; Charbit1, Bruno; Leboulanger, Nicolas; Jahrsdörfer, Bernd; Richard, Yolande; Korganow, Anne-Sophie; Münch, Jan; Nisole, Sébastien; Duffy, Darragh; Herbeuval, Jean-Philippe

Control of TLR7-mediated type i IFN signaling in pDCs through CXCR4 engagement - A new target for lupus treatment

In: Science Advances Vol. 5 (2019) Nr. 7, pp. eaav9019

ISSN: 2375-2548

Online Full Text: dx.doi.org/ (Open Access)
Quambusch, Lena; Landel, Ina; Depta, Laura; Weisner, Jörn; Uhlenbrock, Niklas; Müller, Matthias P.; Glanemann, Franziska; Althoff, Kristina; Siveke, Jens; Rauh, Daniel

Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity

In: Angewandte Chemie International Edition Vol. 58 (2019) Nr. 52, pp. 18823 - 18829

ISSN: 1433-7851; 1521-3773

Online Full Text: dx.doi.org/ (Open Access)
Rubio, Ignacio; Osuchowski, Marcin F; Shankar-Hari, Manu; Skirecki, Tomasz; Winkler, Martin Sebastian; Lachmann, Gunnar; La Rosée, Paul; Monneret, Guillaume; Venet, Fabienne; Bauer, Michael; Brunkhorst, Frank M; Kox, Matthijs; Cavaillon, Jean-Marc; Uhle, Florian; Weigand, Markus A; Flohe, Stefanie; Wiersinga, W Joost; Martin-Fernandez, Marta; Almansa, Raquel; Martin-Loeches, Ignacio; Torres, Antoni; Giamarellos-Bourboulis, Evangelos J; Girardis, Massimo; Cossarizza, Andrea; Netea, Mihai G; van der Poll, Tom; Scherag, Andre; Meisel, Christian; Schefold, Joerg C; Bermejo-Martín, Jesús F

Current gaps in sepsis immunology: new opportunities for translational research

In: The Lancet Infectious Diseases Vol. 19 (2019) Nr. 12, pp. e422 - e436

ISSN: 1474-4457; 1473-3099

Online Full Text: dx.doi.org/ (Open Access)
Vokes, Natalie; Margolis, Claire; Liu, David; Schilling, Bastian; Schadendorf, Dirk; Van Allen, Eliezer Mendel

Distinct immunogenomic properties of melanomas with stable disease as best response to immune checkpoint blockade (ICB)

In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15_Suppl, pp. 2515 - 2515

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Kurtz, David M.; Esfahani, Mohammad S.; Scherer, Florian; Soo, Joanne; Jin, Michael C.; Liu, Chih Long; Newman, Aaron M.; Dührsen, Ulrich; Hüttmann, Andreas; Casasnovas, Olivier; Westin, Jason R.; Ritgen, Matthais; Böttcher, Sebastian; Langerak, Anton W.; Roschewski, Mark; Wilson, Wyndham H.; Gaidano, Gianluca; Rossi, Davide; Bahlo, Jasmin; Hallek, Michael; Tibshirani, Robert; Diehn, Maximilian; Alizadeh, Ash A.

Dynamic Risk Profiling Using Serial Tumor Biomarkers for Personalized Outcome Prediction

In: Cell Vol. 178 (2019) Nr. 3, pp. 699 - 713.e19

ISSN: 0092-8674; 1097-4172

Online Full Text: dx.doi.org/ (Open Access)
Jackstadt, Rene; van Hooff, Sander R.; Leach, Joshua D.; Cortes-Lavaud, Xabier; Lohuis, Jeroen O.; Ridgway, Rachel A.; Wouters, Valérie M.; Roper, Jatin; Kendall, Timothy J.; Roxburgh, Campbell S.; Horgan, Paul G.; Nixon, Colin; Nourse, Craig; Gunzer, Matthias; Clark, William; Hedley, Ann; Yilmaz, Omer H.; Rashid, Mamunur; Bailey, Peter; Biankin, Andrew V.; Campbell, Andrew D.; Adams, David J.; Barry, Simon T.; Steele, Colin W.; Medema, Jan Paul; Sansom, Owen J.

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

In: Cancer Cell Vol. 36 (2019) Nr. 3, pp. 319 - 336.e7

ISSN: 1535-6108

Online Full Text: dx.doi.org/ (Open Access)
Lebbé, Celeste; Meyer, Nicolas; Mortier, Laurent; Marquez-Rodas, Ivan; Robert, Caroline; Rutkowski, Piotr; Menzies, Alexander M.; Eigentler, Thomas; Ascierto, Paolo A.; Smylie, Michael; Schadendorf, Dirk; Ajaz, Mazhar; Svane, Inge Marie; Gonzalez, Rene; Rollin, Linda; Lord-Bessen, Jennifer; Saci, Abdel; Grigoryeva, Elena; Pigozzo, Jacopo

Evaluation of Two Dosing Regimens for Nivolumab in Combination With Ipilimumab in Patients With Advanced Melanoma : Results From the Phase IIIb/IV CheckMate 511 Trial

In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 11, pp. 867 - 875

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/ (Open Access)
Silvestre-Roig, Carlos; Braster, Quinte; Wichapong, Kanin; Lee, Ernest Y.; Teulon, Jean Marie; Berrebeh, Nihel; Winter, Janine; Adrover, José M.; Santos, Giancarlo Santiago; Froese, Alexander; Lemnitzer, Patricia; Ortega-Gómez, Almudena; Chevre, Raphael; Marschner, Julian; Schumski, Ariane; Winter, Carla; Perez-Olivares, Laura; Pan, Chang; Paulin, Nicole; Schoufour, Tom; Hartwig, Helene; González-Ramos, Silvia; Kamp, Frits; Megens, Remco T. A.; Mowen, Kerri A.; Gunzer, Matthias; Maegdefessel, Lars; Hackeng, Tilman; Lutgens, Esther; Daemen, Mat; von Blume, Julia; Anders, Hans-Joachim; Nikolaev, Viacheslav O.; Pellequer, Jean-Luc; Weber, Christian; Hidalgo, Andrés; Nicolaes, Gerry A. F.; Wong, Gerard C. L.; Soehnlein, Oliver

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

In: Nature Vol. 569 (2019) Nr. 7755, pp. 236 - 240

ISSN: 0028-0836; 1476-4687

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Stepanova, Tatyana; Haefeli, Walter-Emil; Dittmer, Ulf; Ciesek, Sandra; Bremer, Birgit; Dandri, Maura; Burhenne, Jürgen; Voronkova, Natalia; Wedemeyer, Heiner; Alexandrov, Alexander; Urban, Stephan; Allweiss, Lena; Bogomolov, Pavel O.; Schöneweis, Katrin; Chulanov, Vladimir

Final results of a multicenter, open-label phase 2 clinical trial (MYR203) to assess safety and efficacy of myrcludex B in cwith PEG-interferon Alpha 2a in patients with chronic HBV/HDV co-infection

In: Journal of Hepatology Vol. 70 (2019) Nr. 1 Suppl., pp. e81

ISSN: 0168-8278

Online Full Text: dx.doi.org/
Larkin, James; Chiarion-Sileni, Vanna; Gonzalez, Rene; Grob, Jean-Jacques; Rutkowski, Piotr; Lao, Christopher D.; Cowey, C Lance; Schadendorf, Dirk; Wagstaff, John; Dummer, Reinhard; Ferrucci, Pier F.; Smylie, Michael; Hogg, David; Hill, Andrew; Márquez-Rodas, Ivan; Haanen, John; Guidoboni, Massimo; Maio, Michele; Schöffski, Patrick; Carlino, Matteo S.; Lebbé, Céleste; McArthur, Grant; Ascierto, Paolo A.; Daniels, Gregory A.; Long, Georgina V.; Bastholt, Lars; Rizzo, Jasmine I.; Balogh, Agnes; Moshyk, Andriy; Hodi, F Stephen; Wolchok, Jedd D.

Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

In: The New England Journal of Medicine Vol. 381 (2019) Nr. 16, pp. 1535 - 1546

ISSN: 1533-4406

Online Full Text: dx.doi.org/
Robert, C.; Grob, J.J.; Stroyakovskiy, D.; Karaszewska, B.; Hauschild, A.; Levchenko, E.; Chiarion Sileni, V.; Schachter, J.; Garbe, C.; Bondarenko, I.; Gogas, H.; Mandalá, M.; Haanen, J.B.A.G.; Lebbé, C.; MacKiewicz, A.; Rutkowski, P.; Nathan, P.D.; Ribas, A.; Davies, M.A.; Flaherty, K.T.; Burgess, P.; Tan, M.; Gasal, E.; Voi, M.; Schadendorf, Dirk; Long, G.V.; Grob, Jean J.; Haanen, John B.A.G.; Nathan, Paul D.; Davies, Michael A.; Flaherty, Keith T.; Long, Georgina V.

Five-year outcomes with dabrafenib plus trametinib in metastatic melanoma

In: The New England Journal of Medicine Vol. 381 (2019) Nr. 7, pp. 626 - 636

ISSN: 1533-4406; 0028-4793

Online Full Text: dx.doi.org/
Dittmer, Ulf; Sutter, Kathrin; Kassiotis, George; Zelinskyy, Gennadiy; Bánki, Zoltán; Stoiber, Heribert; Santiago, Mario L.; Hasenkrug, Kim J.

Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity

In: FEMS Microbiology Reviews Vol. 43 (2019) Nr. 5, pp. 435 - 456

ISSN: 1574-6976; 0168-6445

Online Full Text: dx.doi.org/
Watson, Hunna J.; Hinney, Anke; Giuranna, Johanna; Hebebrand, Johannes

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

In: Nature Genetics Vol. 51 (2019) Nr. 8, pp. 1207 - 1214

ISSN: 1061-4036; 1546-1718

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Cheng, Shifeng; Xian, Wenfei; Fu, Yuan; Marin, Birger; Keller, Jean; Wu, Tian; Sun, Wenjing; Li, Xiuli; Xu, Yan; Zhang, Yu; Wittek, Sebastian; Reder, Tanja; Günther, Gerd; Gontcharov, Andrey; Wang, Sibo; Li, Linzhou; Liu, Xin; Wang, Jian; Yang, Huanming; Xu, Xun; Delaux, Pierre-Marc; Melkonian, Barbara; Wong, Gane Ka-Shu; Melkonian, Michael

Genomes of Subaerial Zygnematophyceae Provide Insights into Land Plant Evolution

In: Cell Vol. 179 (2019) Nr. 5, pp. 1057 - 1067.e14

ISSN: 0092-8674; 0092-8674

Online Full Text: dx.doi.org/
Peters, Triinu; Hebebrand, Johannes; Hinney, Anke; Scherag, Andre; Depienne, C.

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms Across Eight Psychiatric Disorders

In: Cell Vol. 179 (2019) Nr. 7, pp. 1469 - 1482.e11.

ISSN: 0092-8674; 1097-4172

Online Full Text: dx.doi.org/
López, Cristina; Kleinheinz, Kortine; Aukema, Sietse M.; Rohde, Marius; Bernhart, Stephan H.; Hübschmann, Daniel; Wagener, Rabea; Toprak, Umut H.; Raimondi, Francesco; Kreuz, Markus; Waszak, Sebastian M.; Huang, Zhiqin; Sieverling, Lina; Paramasivam, Nagarajan; Seufert, Julian; Sungalee, Stephanie; Russell, Robert B.; Bausinger, Julia; Kretzmer, Helene; Ammerpohl, Ole; Bergmann, Anke K.; Binder, Hans; Borkhardt, Arndt; Brors, Benedikt; Claviez, Alexander; Doose, Gero; Feuerbach, Lars; Haake, Andrea; Hansmann, Martin-Leo; Hoell, Jessica; Hummel, Michael; Korbel, Jan O.; Lawerenz, Chris; Lenze, Dido; Radlwimmer, Bernhard; Richter, Julia; Rosenstiel, Philip; Rosenwald, Andreas; Schilhabel, Markus B.; Stein, Harald; Stilgenbauer, Stephan; Stadler, Peter F.; Szczepanowski, Monika; Weniger, Marc; Zapatka, Marc; Eils, Roland; Lichter, Peter; Loeffler, Markus; Möller, Peter; Trümper, Lorenz; Klapper, Wolfram; Wagner, Susanne; Richter, Gesine; Eils, Jürgen; Kerssemakers, Jules; Jaeger-Schmidt, Christina; Scholz, Ingrid; Borst, Christoph; Braulke, Friederike; Dreyling, Martin; Eberth, Sonja; Einsele, Hermann; Frickhofen, Norbert; Haas, Siegfried; Karsch, Dennis; Klepl, Nicole; Kneba, Michael; Lisfeld, Jasmin; Mantovani-Löffler, Luisa; Ott, German; Stadler, Christina; Staib, Peter; Zenz, Thorsten; Kube, Dieter; Kostezka, Ulrike; Binder, Vera; Leich, Ellen; Nagel, Inga; Pischimariov, Jordan; Schreiber, Stefan; Vater, Inga; Hopp, Lydia; Langenberger, David; Rosolowski, Maciej; Hoffmann, Steve; Küppers, Ralf; Burkhardt, Birgit; Schlesner, Matthias; Siebert, Reiner

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1459

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Buscaill, Pierre; Chandrasekar, Balakumaran; Sanguankiattichai, Nattapong; Kourelis, Jiorgos; Kaschani, Farnusch; Thomas, Emma L.; Morimoto, Kyoko; Kaiser, Markus; Preston, Gail M.; Ichinose, Yuki; Van Der Hoorn, Renier A.L.

Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptides

In: Science Vol. 364 (2019) Nr. 6436, pp. eaav0748

ISSN: 1095-9203; 0036-8075

Online Full Text: dx.doi.org/
Emmons, Michael F.; Faião-Flores, Fernanda; Sharma, Ritin; Thapa, Ram; Messina, Jane L.; Becker, Jürgen; Schadendorf, Dirk; Seto, Edward; Sondak, Vernon K.; Koomen, John M.; Chen, Yian A.; Lau, Eric K.; Wan, Lixin; Licht, Jonathan D.; Smalley, Keiran S. M.

HDAC8 regulates a stress response pathway in melanoma to mediate escape from BRAF inhibitor therapy

In: Cancer Research Vol. 79 (2019) Nr. 11, pp. 2947 - 2961

ISSN: 0008-5472; 0099-7013; 0099-7374; 1538-7445

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Toffalori, Cristina; Zito, Laura; Gambacorta, Valentina; Riba, Michaela; Oliveira, Giacomo; Bucci, Gabriele; Barcella, Matteo; Spinelli, Orietta; Greco, Raffaella; Crucitti, Lara; Cieri, Nicoletta; Noviello, Maddalena; Manfredi, Francesco; Montaldo, Elisa; Ostuni, Renato; Naldini, Matteo M.; Gentner, Bernhard; Waterhouse, Miguel; Zeiser, Robert; Finke, Jürgen; Hanoun, Maher; Beelen, Dietrich; Gojo, Ivana; Luznik, Leo; Onozawa, Masahiro; Teshima, Takanori; Devillier, Raynier; Blaise, Didier; Halkes, Constantijn J.M.; Griffioen, Marieke; Carrabba, Matteo G.; Bernardi, Massimo; Peccatori, Jacopo; Barlassina, Cristina; Stupka, Elia; Lazarevic, Dejan; Tonon, Giovanni; Rambaldi, Alessandro; Cittaro, Davide; Bonini, Chiara; Fleischhauer, Katharina; Ciceri, Fabio; Vago, Luca

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation

In: Nature Medicine Vol. 25 (2019) Nr. 4, pp. 603 - 611

ISSN: 1546-170X; 1078-8956

Online Full Text: dx.doi.org/
Liu, David; Schilling, Bastian; Liu, Derek; Sucker, Antje; Livingstone, Elisabeth; Jerby-Amon, Livnat; Zimmer, Lisa; Gutzmer, Ralf; Satzger, Imke; Loquai, Carmen; Grabbe, Stephan; Vokes, Natalie; Margolis, Claire A.; Conway, Jake; He, Meng Xiao; Elmarakeby, Haitham; Dietlein, Felix; Miao, Diana; Tracy, Adam; Gogas, Helen; Goldinger, Simone M.; Utikal, Jochen; Blank, Christian U.; Rauschenberg, Ricarda; Bubnoff, Dagmar von; Krackhardt, Angela; Weide, Benjamin; Haferkamp, Sebastian; Kiecker, Felix; Izar, Ben; Garraway, Levi; Regev, Aviv; Flaherty, Keith; Paschen, Annette; Allen, Eliezer M. van; Schadendorf, Dirk

Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

In: Nature Medicine Vol. 25 (2019) Nr. 12, pp. 1916 - 1927

ISSN: 1078-8956; 1546-170X

Online Full Text: dx.doi.org/ (Open Access)
Hüllein, Jennifer; Słabicki, Mikołaj; Rosolowski, Maciej; Jethwa, Alexander; Habringer, Stefan; Tomska, Katarzyna; Kurilov, Roma; Lu, Junyan; Scheinost, Sebastian; Wagener, Rabea; Huang, Zhiqin; Lukas, Marina; Yavorska, Olena; Helfrich, Hanne; Scholtysik, René; Bonneau, Kyle; Tedesco, Donato; Küppers, Ralf; Klapper, Wolfram; Pott, Christiane; Stilgenbauer, Stephan; Burkhardt, Birgit; Löffler, Markus; Trümper, Lorenz H.; Hummel, Michael; Brors, Benedikt; Zapatka, Marc; Siebert, Reiner; Kreuz, Markus; Keller, Ulrich; Huber, Wolfgang; Zenz, Thorsten

MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma

In: Cancer Research Vol. 79 (2019) Nr. 12, pp. 3125 - 3138

ISSN: 1538-7445; 0008-5472

Online Full Text: dx.doi.org/
Yang, Shangqing; Wang, Lu; Pan, Wen; Bayer, Wibke; Thoens, Christine; Heim, Kathrin; Dittmer, Ulf; Timm, Jörg; Wang, Qin; Yu, Qing; Luo, Jinzhuo; Liu, Yanan; Hofmann, Maike; Thimme, Robert; Zhang, Xiaoyong; Chen, Hongtao; Wang, Hua; Feng, Xuemei; Yang, Xuecheng; Lu, Yinping; Lu, Mengji; Yang, Dongliang; Liu, Jia

MMP2/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearance

In: Journal of Hepatology Vol. 71 (2019) Nr. 4, pp. 685 - 698

ISSN: 1600-0641; 0168-8278

Online Full Text: dx.doi.org/
Wiesweg, Marcel; Mairinger, Fabian; Reis, Henning; Goetz, Moritz; Walter, Robert; Hager, Thomas; Metzenmacher, Martin; Eberhardt, Wilfried; McCutcheon, A.; Köster, J.; Stuschke, Martin; Aigner, Clemens; Darwiche, Kaid; Schmid, Kurt Werner; Rahmann, Sven; Schuler, Martin

Machine learning-based predictors for immune checkpoint inhibitor therapy of non-small-cell lung cancer

In: Annals of Oncology Vol. 30 (2019) Nr. 4, pp. 655 - 657

ISSN: 1569-8041; 0923-7534

Online Full Text: dx.doi.org/ (Open Access)
Pan, Dongqing; Walstein, Kai; Take, Annika; Bier, David; Kaiser, Nadine; Musacchio, Andrea

Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 4046

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Fleming, Viktor; Hu, Xiaoying; Weller, Céline; Weber, Rebekka; Groth, Christopher; Riester, Zeno; Hüser, Laura; Sun, Qian; Nagibin, Vasyl; Kirschning, Carsten Jürgen; Bronte, Vincenzo; Utikal, Jochen; Altevogt, Peter; Umansky, Viktor

Melanoma extracellular vesicles generate immunosuppressive myeloid cells by upregulating PD-L1 via TLR4 signaling

In: Cancer Research Vol. 79 (2019) Nr. 18, pp. 4715 - 4728

ISSN: 0099-7013; 0008-5472

Online Full Text: dx.doi.org/
Otxoa-de-Amezaga, Amaia; Miró-Mur, Francesc; Pedragosa, Jordi; Gallizioli, Mattia; Justicia, Carles; Gaja-Capdevila, Núria; Ruíz-Jaen, Francisca; Salas-Perdomo, Angélica; Bosch, Anna; Calvo, Maria; Márquez-Kisinousky, Leonardo; Denes, Adam; Gunzer, Matthias; Planas, Anna M.

Microglial cell loss after ischemic stroke favors brain neutrophil accumulation

In: Acta Neuropathologica Vol. 137 (2019) Nr. 2, pp. 321 - 341

ISSN: 1432-0533; 0001-6322

Online Full Text: dx.doi.org/ (Open Access)
Hellerschmied-Jelinek, Doris; Lehner, Anita; Franicevic, Nina; Arnese, Renato; Johnson, Chloe; Vogel, Antonia; Meinhart, Anton; Kurzbauer, Robert; Deszcz, Luiza; Gazda, Linn; Geeves, Michael; Clausen, Tim

Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 4781

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Karimzadeh, Hadi; Kiraithe, Muthamia M.; Oberhardt, Valerie; Salimi Alizei, Elahe; Bockmann, Jan; Schulze zur Wiesch, Julian; Budeus, Bettina; Hoffmann, Daniel; Wedemeyer, Heiner; Cornberg, Markus; Krawczyk, Adalbert; Rashidi-Alavijeh, Jassin; Rodríguez-Frías, Francisco; Casillas, Rosario; Buti, Maria; Smedile, Antonina; Alavian, Seyed Moayed; Heinold, Andreas; Emmerich, Florian; Panning, Marcus; Gostick, Emma; Price, David A.; Timm, Jörg; Hofmann, Maike; Raziorrouh, Bijan; Thimme, Robert; Protzer, Ulrike; Roggendorf, Michael; Neumann-Haefelin, Christoph

Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8⁺ T Cells and Evolve at the Population Level

In: Gastroenterology Vol. 156 (2019) Nr. 6, pp. 1820 - 1833

ISSN: 0016-5085; 1528-0012

Online Full Text: dx.doi.org/ (Open Access)
Urbonas, Vincas; Schadendorf, Dirk; Zimmer, Lisa; Danson, Sarah J.; Marshall, Ernest; Corrie, Pippa G.; Wheater, Matthew J.; Plummer, E.; Mauch, Cornelia; Scudder, Claire; Goff, Matthew; Love, Sharon B.; Mohammed, S.B.; Middleton, Mark R.

Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF melanoma (PACMEL) : a multicentre, open-label, randomised, controlled phase II trial

In: Annals of Oncology Vol. 30 (2019) Nr. 2, pp. 317 - 324

ISSN: 1569-8041; 0923-7534

Online Full Text: dx.doi.org/ (Open Access)
Schadendorf, Dirk; Hauschild, Axel; Santinami, Mario; Atkinson, Victoria; Mandalà, Mario; Chiarion-Sileni, Vanna; Larkin, James; Nyakas, Marta; Dutriaux, Caroline; Haydon, Andrew; Robert, Caroline; Mortier, Laurent; Lesimple, Thierry; Plummer, Ruth; Schachter, Jacob; Dasgupta, Kohinoor; Manson, Stephanie; Koruth, Roy; Mookerjee, Bijoyesh; Kefford, Richard; Dummer, Reinhard; Kirkwood, John M.; Long, Georgina V.

Patient-reported outcomes in patients with resected, high-risk melanoma with BRAFV600E or BRAFV600K mutations treated with adjuvant dabrafenib plus trametinib (COMBI-AD) : a randomised, placebo-controlled, phase 3 trial

In: The Lancet Oncology Vol. 20 (2019) Nr. 5, pp. 701 - 710

ISSN: 1474-5488

Online Full Text: dx.doi.org/
Al-Batran, Salah-Eddin; Homann, Nils; Pauligk, Claudia; Goetze, Thorsten O.; Meiler, Johannes; Kasper, Stefan; Kopp, Hans-Georg; Mayer, Frank; Haag, Georg Martin; Luley, Kim; Lindig, Udo; Schmiegel, Wolff; Pohl, Michael; Stoehlmacher, Jan; Folprecht, Gunnar; Probst, Stephan; Prasnikar, Nicole; Fischbach, Wolfgang; Mahlberg, Rolf; Trojan, Jörg; Koenigsmann, Michael; Martens, Uwe M.; Thuss-Patience, Peter; Egger, Matthias; Block, Andreas; Heinemann, Volker; Illerhaus, Gerald; Moehler, Markus; Schenk, Michael; Kullmann, Frank; Behringer, Dirk M.; Heike, Michael; Pink, Daniel; Teschendorf, Christian; Löhr, Carmen; Bernhard, Helga; Schuch, Gunter; Rethwisch, Volker; Weikersthal, Ludwig Fischer von; Hartmann, Jörg T.; Kneba, Michael; Daum, Severin; Schulmann, Karsten; Weniger, Jörg; Belle, Sebastian; Gaiser, Timo; Oduncu, Fuat S.; Güntner, Martina; Hozaeel, Wael; Reichart, Alexander; Jäger, Elke; Kraus, Thomas; Mönig, Stefan; Bechstein, Wolf O.; Schuler, Martin; Schmalenberg, Harald; Hofheinz, Ralf D.

Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4) : a randomised, phase 2/3 trial

In: The Lancet Vol. 393 (2019) Nr. 10184, pp. 1948 - 1957

ISSN: 0140-6736; 0023-7507; 1474-547X

Online Full Text: dx.doi.org/
Fuchs, Michael; Goergen, Helen; Kobe, Carsten; Kuhnert, Georg; Lohri, Andreas; Greil, Richard; Sasse, Stephanie; Topp, Max S.; Schäfer, Erhardt; Hertenstein, Bernd; Soekler, Martin; Vogelhuber, Martin; Zijlstra, Josée M.; Keller, Ulrich Bernd; Krause, Stefan W.; Wilhelm, Martin; Maschmeyer, Georg; Thiemer, Julia; Dührsen, Ulrich; Meissner, Julia; Viardot, Andreas; Eich, Hans; Baues, Christian; Diehl, Volker; Rosenwald, Andreas; von Tresckow, Bastian; Dietlein, Markus; Borchmann, Peter; Engert, Andreas

Positron Emission Tomography-Guided Treatment in Early-Stage Favorable Hodgkin Lymphoma : Final Results of the International, Randomized Phase III HD16 Trial by the German Hodgkin Study Group

In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 31, pp. 2835 - 2845

ISSN: 1527-7755; 0732-183X

Online Full Text: dx.doi.org/
Weisner, Jörn; Landel, Ina; Reintjes, Christoph; Uhlenbrock, Niklas; Trajkovic-Arsic, Marija; Dienstbier, Niklas; Hardick, Julia; Ladigan, Swetlana; Lindemann, Marius; Smith, Steven; Quambusch, Lena; Scheinpflug, Rebekka; Depta, Laura; Gontla, Rajesh; Unger, Anke; Müller, Heiko; Baumann, Matthias; Schultz-Fademrecht, Carsten; Gunther, Georgia; Maghnouj, Abdelouahid; Müller, Matthias P.; Pohl, Michael; Teschendorf, Christian; Wolters, Heiner; Viebahn, Richard; Tannapfel, Andrea; Uhl, Waldemar; Hengstler, Jan G.; Hahn, Stephan A.; Siveke, Jens; Rauh, Daniel

Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer

In: Cancer Research Vol. 79 (2019) Nr. 9, pp. 2367 - 2378

ISSN: 0008-5472; 1538-7445; 0099-7013; 0099-7374

Online Full Text: dx.doi.org/
Schadendorf, Dirk; Melanoma GWAS Consortium

Publisher Correction : Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 299

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Merz, Simon F.; Korste, Sebastian; Bornemann, Lea; Michel, Lars; Stock, Pia; Squire, Anthony; Soun, Camille; Engel, Daniel Robert; Detzer, Julia; Lörchner, Holger; Hermann, Dirk M.; Kamler, Markus; Klode, Joachim; Hendgen-Cotta, Ulrike B.; Rassaf, Tienush; Gunzer, Matthias; Totzeck, Matthias

Publisher Correction: Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2768

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Duffy, David L.; Zhu, Gu; Li, Xin; Sanna, Marianna; Jacobs, Leonie C.; Evans, David M.; Yazar, Seyhan; Beesley, Jonathan; Lawrence, Matthew H.; Kraft, Peter; Visconti, Alessia; Taylor, John C.; Lui, Fan; Wright, Margaret J.; Henders, Anjali K.; Bowdler, Lisa; Glass, Dan; Ikram, Arfan M.; Uitterlinden, André G.; Madden, Pamela A.; Heath, Andrew C.; Nelson, Elliot C.; Green, Adele C.; Chanock, Stephen; Barrett, Jennifer H.; Brown, Matthew A.; Hayward, Nicholas K.; MacGregor, Stuart; Sturm, Richard A.; Hewitt, Alex W.; Leenhardt, Jeffrey E.; Brossard, Myriam; Moses, Eric K.; Song, Fengju; Kumar, Rajiv; Easton, Douglas F.; Pharoah, Paul D. P.; Swerdlow, Anthony J.; Kypreou, Katerina P.; Harland, Mark; Randerson-Moor, Juliette; Akslen, Lars A.; Andresen, Per A.; Avril, Marie-Françoise; Azizi, Esther; Scarrà, Giovanna Bianchi; Brown, Kevin M.; Dębniak, Tadeusz; Elder, David E.; Fang, Shenying; Friedman, Eitan; Galan, Pilar; Ghiorzo, Paola; Gillanders, Elizabeth M.; Goldstein, Alisa M.; Gruis, Nelleke A.; Hansson, Johan; Helsing, Per; Hočevar, Marko; Höiom, Veronica; Ingvar, Christian; Kanetsky, Peter A.; Chen, Wei V.; Landi, Maria Teresa; Lang, Julie; Lathrop, G. Mark; Lubiński, Jan; Mackie, Rona M.; Mann, Graham J.; Molven, Anders; Novaković, Srdjan; Olsson, Håkan; Puig, Susana; Puig-Butille, Joan Anton; Radford-Smith, Graham L.; van Doorn, Remco; Whiteman, David C.; Craig, Jamie E.; Schadendorf, Dirk; Simms, Lisa A.; Burdon, Kathryn P.; Nyholt, Dale R.; Pooley, Karen A.; Orr, Nicholas; Stratigos, Alexander J.; Cust, Anne E.; Ward, Sarah V.; Schulze, Hans-Joachim; Dunning, Alison M.; Demenais, Florence; Amos, Christopher I.; Kayser, Manfred; Hunter, David J.; Newton Bishop, Julia A.; Spector, Timothy D.; Montgomery, Grant W.; Mackey, David A.; Smith, George Davey; Nijsten, Tamar E.; Bishop, D. Timothy; Bataille, Veronique; Falchi, Mario; Han, Jiali; Martin, Nicholas G.

Publisher Correction: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 299

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Taylor, Fiona; Regan, Meredith M.; Schadendorf, Dirk; Atkins, Michael B.; Lawrance, Rachael; Moreno-Koehler, Alejandro; Moshyk, Andriy; Rao, Sumati; Ritchings, Corey; KOTAPATI, SRIVIDYA; Lord-Bessen, Jennifer; Rizzo, Jasmine I.; McDermott, David F.; Middleton, Mark R.

Quality of life (QoL) and symptom burden in patients (pts) with advanced melanoma during the treatment-free interval (TFI) after discontinuation of nivolumab (NIVO) or NIVO plus ipilimumab (IPI)

In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15_Suppl, pp. 9568

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Younes, Anas; Sehn, Laurie H.; Johnson, Peter; Zinzani, Pier Luigi; Hong, Xiaonan; Zhu, Jun; Patti, Caterina; Belada, David; Samoilova, Olga; Suh, Cheolwon; Leppä, Sirpa; Rai, Shinya; Turgut, Mehmet; Jurczak, Wojciech; Cheung, Matthew C.; Gurion, Ronit; Yeh, Su-Peng; Lopez-Hernandez, Andres; Dührsen, Ulrich; Thieblemont, Catherine; Chiattone, Carlos Sergio; Balasubramanian, Sriram; Carey, Jodi; Liu, Grace; Martin Shreeve, S.; Sun, Steven; Zhuang, Sen Hong; Vermeulen, Jessica; Staudt, Louis M.; Wilson, Wyndham

Randomized phase III trial of ibrutinib and rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in non–germinal center B-cell diffuse large B-cell lymphoma

In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15, pp. 1285 - 1295

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Tran, Vi; Walkenfort, Bernd; König, Matthias; Salehi, Mohammad; Schlücker, Sebastian

Rapid, Quantitative, and Ultrasensitive Point-of-Care Testing : A Portable SERS Reader for Lateral Flow Assays in Clinical Chemistry

In: Angewandte Chemie International Edition Vol. 58 (2019) Nr. 2, pp. 442 - 446

ISSN: 1521-3773; 1433-7851

Online Full Text: dx.doi.org/ (Open Access)
Long, Georgina V.; Dummer, Reinhard; Schadendorf, Dirk; Santinami, Mario; Atkinson, Victoria; Mandalà, Mario; Chiarion-Sileni, Vanna; Larkin, James; Nyakas, Marta; Dutriaux, Caroline; Haydon, Andrew; Robert, Caroline; Mortier, Laurent; Schachter, Jacob; Lesimple, Thierry; Plummer, Ruth; Dasgupta, Kohinoor; Haas, Tomas; Shilkrut, Mark; Gasal, Eduard; Kefford, Richard; Kirkwood, John M.; Hauschild, Axel

Reply to E. Hindié and K.R. Hess

In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15, pp. 1356 - 1358

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Kurtz, David M.; Scherer, Florian; Jin, Michael; Soo, Joanne; Craig, Alexander F.M.; Esfahani, Mohammad Shahrokh; Chabon, Jacob J.; Stehr, Henning; Liu, Chih Long; Tibshirani, Robert; Maeda, Lauren S.; Gupta, Neel K.; Khodadoust, Michael S.; Advani, Ranjana H.; Newman, Aaron M.; Dührsen, Ulrich; Hüttmann, Andreas; Meignan, Michel; Casasnovas, Olivier; Westin, Jason R.; Roschewski, Mark; Wilson, Wyndham H.; Gaidano, Gianluca; Rossi, Davide; Diehn, Maximilian; Alizadeh, Ash A.

Reply to J. Wang et al

In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 9, pp. 755 - 758

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Schuler, Martin; Cho, Byoung Chul; Sayehli, Cyrus Michael; Navarro, Alejandro; Soo, Ross A.; Richly, Heike; Cassier, Philippe Alexandre; Tai, David; Penel, Nicolas; Nogova, Lucia; Park, Se Hoon; Schostak, Martin; Gajate, Pablo; Cathomas, Richard; Rajagopalan, Prabhu; Grevel, Joachim; Bender, Sebastian; Boix, Oliver; Nogai, Hendrik; Ocker, Matthias; Ellinghaus, Peter; Joerger, Markus

Rogaratinib in patients with advanced cancers selected by FGFR mRNA expression : a phase 1 dose-escalation and dose-expansion study

In: The Lancet Oncology Vol. 20 (2019) Nr. 10, pp. 1454 - 1466

ISSN: 1470-2045; 1474-5488

Online Full Text: dx.doi.org/
Weichenthal, Michael; Ugurel, Selma; Leiter, Ulrike M.; Satzger, Imke; Kähler, Katharina C.; Welzel, Julia; Pföhler, Claudia; Feldmann-Böddeker, Ingrid; Meier, Friedegund Elke; Terheyden, Patrick; Haferkamp, Sebastian; Herbst, Rudolf; Ulrich, Jens; Utikal, Jochen; Kreuter, Alexander; Gutzmer, Ralf; Schadendorf, Dirk; Mohr, Peter

Salvage therapy after failure from anti-PD-1 single agent treatment : A Study by the German ADOReg melanoma registry

In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15_Suppl, pp. 9505

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Kosinski, Richard; Mukhortava, Ann; Pfeifer, Wolfgang; Candelli, Andrea; Rauch, Philipp; Sacca, Barbara

Sites of high local frustration in DNA origami

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1061

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Ascierto, Paolo A.; Long, Georgina V.; Robert, Caroline; Brady, Benjamin; Dutriaux, Caroline; Di Giacomo, Anna Maria; Mortier, Laurent; Hassel, Jessica C.; Rutkowski, Piotr; McNeil, Catriona; Kalinka-Warzocha, Ewa; Savage, Kerry J.; Hernberg, Micaela M.; Lebbé, Celeste; Charles, Julie; Mihalcioiu, Catalin; Chiarion-Sileni, Vanna; Mauch, Cornelia; Cognetti, Francesco; Ny, Lars; Arance, Ana; Svane, Inge Marie; Schadendorf, Dirk; Gogas, Helen; Saci, Abdel; Jiang, Joel; Rizzo, Jasmine; Atkinson, Victoria

Survival Outcomes in Patients with Previously Untreated BRAF Wild-Type Advanced Melanoma Treated with Nivolumab Therapy : Three-Year Follow-up of a Randomized Phase 3 Trial

In: JAMA Oncology Vol. 5 (2019) Nr. 2, pp. 187 - 194

ISSN: 2374-2445; 2374-2437

Online Full Text: dx.doi.org/
Niemeyer, Johannes; Mentrup, Torben; Heidasch, Ronny; Müller, Stephan A; Biswas, Uddipta; Meyer, Rieke; Papadopoulou, Alkmini A.; Dederer, Verena; Haug-Kröper, Martina; Adamski, Vivian; Lüllmann-Rauch, Renate; Bergmann, Martin; Mayerhofer, Artur; Saftig, Paul; Wennemuth, Gunther; Jessberger, Rolf; Fluhrer, Regina; Lichtenthaler, Stefan F.; Lemberg, Marius K.; Schröder, Bernd

The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban

In: EMBO Reports Vol. 20 (2019) Nr. 3, pp. e46449

ISSN: 1469-3178; 1469-221X

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Körver, Lisa; Papadopoulos, Chrisovalantis; Liu, Bin; Kravic, Bojana; Rota, Giulia; Brecht, Lukas; Veenendaal, Tineke; Polajnar, Mira; Blümke, Anika; Ehrmann, Michael; Klumperman, Judith; Jäättelä, Marja; Behrends, Christian; Meyer, Hemmo

The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage

In: EMBO Reports (2019) pp. e48014

ISSN: 1469-3178; 1469-221X

Online Full Text: dx.doi.org/ (Open Access)
Schadendorf, Dirk; Livingstone, Elisabeth; Zimmer, Lisa

Treatment in metastatic melanoma : Time to re-think

In: Annals of Oncology Vol. 30 (2019) Nr. 4, pp. 501 - 503

ISSN: 0923-7534; 1569-8041

Online Full Text: dx.doi.org/ (Open Access)
Krawczyk, Adalbert; Bazinet, Michel; Pantea, Victor; Cotler, Scott; Dahari, Harel; Shekhtman, Louis; Jimbei, Pavlina; Cojuhari, Lilia; Cebotarescu, Valentin; Uprichard, Susan; Vaillant, Andrew

Understanding HDV and HBsAg kinetics during nucleic acid polymer REP 2139 mono-therapy in HBeAg-negative chronic HBV/HDV co-infected patients via mathematical modeling

In: Journal of Hepatology Vol. 70 (2019) Nr. 1 Suppl., pp. e463

ISSN: 0168-8278

Online Full Text: dx.doi.org/
Florian, Rahel T.; Kraft, Florian; Leitão, Elsa; Kaya, Sabine; Klebe, Stephan; Magnin, Eloi; van Rootselaar, Anne-Fleur; Buratti, Julien; Kühnel, Theresa; Schröder, Christopher; Giesselmann, Sebastian; Tschernoster, Nikolai; Altmueller, Janine; Lamiral, Anaide; Keren, Boris; Nava, Caroline; Bouteiller, Delphine; Forlani, Sylvie; Jornea, Ludmila; Kubica, Regina; Ye, Tao; Plassard, Damien; Jost, Bernard; Meyer, Vincent; Deleuze, Jean-François; Delpu, Yannick; Avarello, Mario D. M.; Vijfhuizen, Lisanne S.; Rudolf, Gabrielle; Hirsch, Edouard; Kroes, Thessa; Reif, Philipp S.; Rosenow, Felix; Ganos, Christos; Vidailhet, Marie; Thivard, Lionel; Mathieu, Alexandre; Bourgeron, Thomas; Kurth, Ingo; Rafehi, Haloom; Steenpass, Laura; Horsthemke, Bernhard; Berkovic, Samuel F.; Bisulli, Francesca; Brancati, Francesco; Canafoglia, Laura; Casari, Giorgio; Guerrini, Renzo; Ishiura, Hiroyuki; Licchetta, Laura; Mei, Davide; Pippucci, Tommaso; Sadleir, Lynette; Scheffer, Ingrid E.; Striano, Pasquale; Tinuper, Paolo; Tsuji, Shoji; Zara, Federico; LeGuern, Eric; Klein, Karl Martin; Labauge, Pierre; Bennett, Mark F.; Bahlo, Melanie; Gecz, Jozef; Corbett, Mark A.; Tijssen, Marina A. J.; van den Maagdenberg, Arn M. J. M.; Depienne, Christel

Unstable TTTTA/TTTCA expansions in MARCH6 are associated with Familial Adult Myoclonic Epilepsy type 3

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 4919

ISSN: 2041-1723

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Alavian, Seyed Moayed; Price, David A.; Panning, Marcus; Neumann-Haefelin, Christoph; Bockmann, Jan; Wiesch, Julian Schulze zur; Wedemeyer, Heiner; Heinold, Andreas; Alizei, Elahe Salimi; Timm, Jörg; Casillas, Rosario; Protzer, Ulrike; Raziorrouh, Bijan; Smedile, Antonina; Rodríguez-Frías, Francisco; Hoffmann, Daniel; Oberhardt, Valerie; Buti, Maria; Thimme, Robert; Roggendorf, Michael; Hofmann, Maike; Gostick, Emma; Budeus, Bettina; Emmerich, Florian; Kiraithe, Muthamia M.; Karimzadeh, Hadi

Viral escape contributes to the failure of hepatitis D virus-specific CD8+ T-cells and drives evolution of HDV

In: Journal of Hepatology Vol. 70 (2019) Nr. Suppl. 1, pp. e21

ISSN: 0168-8278

Online Full Text: dx.doi.org/
Totzeck, Matthias; Mahabadi, Amir Abbas; Schlosser, Thomas Wilfried; Rassaf, Tienush

Weightlifting unmasks high-risk coronary anomaly

In: European Heart Journal Vol. 40 (2019) Nr. 1, pp. 72

ISSN: 0195-668X; 1522-9645

Online Full Text: dx.doi.org/
Sahin, Ugur; Tureci, Özlem; Manikhas, Georgy M.; Lordick, Florian; Rusyn, Andriy; Vynnychenko, Ihor; Dudov, Assen; Bazin, Igor; Bondarenko, Igor; Melichar, Bohuslav; Dhaene, Karl; Wiechen, Kai; Maurus, Daniel; Schuler, Martin; Al-Batran, Salah-Eddin

Zolbetuximab combined with EOX as first-line therapy in advanced CLDN18.2+ gastric (G) and gastroesophageal junction (GEJ) adenocarcinoma : Updated results from the FAST trial.

In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 4_Suppl, pp. 16

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Varaljai, R.; Wistuba-Hamprecht, K.; Seremet, T.; Diaz, JMS; Nsengimana, J.; Sucker, A.; Griewank, Klaus; Horn, Peter; von Neuhoff, N.; Shannan, B.; Chauvistre, H.; Vogel, FCE; Horn, S.; Becker, J. C.; Newton-Bishop, J.; Stang, Andreas; Neyns, B.; Weide, B.; Schadendorf, Dirk; Rösch, Alexander

ctDNA as a noninvasive monitoring tool in metastatic melanoma

In: Journal of Clinical Oncology Vol. 37 (2019) Nr. Suppl. 15, pp. 9548

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/

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Selected Publications 2018

Journal articles

Jerby-Arnon, Livnat; Shah, Parin; Cuoco, Michael S.; Rodman, Christopher; Su, Mei-Ju; Melms, Johannes C.; Leeson, Rachel; Kanodia, Abhay; Mei, Shaolin; Lin, Jia-Ren; Wang, Shu; Rabasha, Bokang; Liu, David; Zhang, Gao; Margolais, Claire; Ashenberg, Orr; Ott, Patrick A.; Buchbinder, Elizabeth I.; Haq, Rizwan; Hodi, F. Stephen; Boland, Genevieve M.; Sullivan, Ryan J.; Frederick, Dennie T.; Miao, Benchun; Moll, Tabea; Flaherty, Keith T.; Herlyn, Meenhard; Jenkins, Russell W.; Thummalapalli, Rohit; Kowalczyk, Monika S.; Cañadas, Israel; Schilling, Bastian; Cartwright, Adam N.R.; Luoma, Adrienne M.; Malu, Shruti; Hwu, Patrick; Bernatchez, Chantale; Forget, Marie-Andrée; Barbie, David A.; Shalek, Alex K.; Tirosh, Itay; Sorger, Peter K.; Wucherpfennig, Kai; Van Allen, Eliezer M.; Schadendorf, Dirk; Johnson, Bruce E.; Rotem, Asaf; Rozenblatt-Rosen, Orit; Garraway, Levi A.; Yoon, Charles H.; Izar, Benjamin; Regev, Aviv

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

In: Cell Vol. 175 (2018) Nr. 4, pp. 984 - 997.e24

ISSN: 1097-4172; 0092-8674

Online Full Text: dx.doi.org/ (Open Access)
Pöhler, Robert; Krahn, Jan; van den Boom, Johannes; Dobrynin, Grzegorz; Kaschani, Farnusch; Eggenweiler, Hans-Michael; Zenke, Frank T.; Kaiser, Markus; Meyer, Hemmo

A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases

In: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 6, pp. 1576 - 1580

ISSN: 1521-3773; 1433-7851; 0570-0833

Online Full Text: dx.doi.org/
Horsthemke, Bernhard

A critical view on transgenerational epigenetic inheritance in humans

In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 2973

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Díaz-Carballo, David; Saka, Sahitya; Klein, Jacqueline; Rennkamp, Tobias; Acikelli, Ali H.; Malak, Sascha; Jastrow, Holger; Wennemuth, Gunther; Tempfer, Clemens; Schmitz, Inge; Tannapfel, Andrea; Strumberg, Dirk

A distinct oncogenerative multinucleated cancer cell serves as a source of stemness and tumor heterogeneity

In: Cancer Research Vol. 78 (2018) Nr. 9, pp. 2318 - 2331

ISSN: 0008-5472; 1538-7445

Online Full Text: dx.doi.org/
Ackermann, Sandra; Cartolano, Maria; Hero, Barbara; Welte, Anne; Kahlert, Yvonne; Roderwieser, Andrea; Bartenhagen, Christoph; Walter, Esther; Gecht, Judith; Kerschke, Laura; Volland, Ruth; Menon, Roopika; Heuckmann, Johannes M.; Gartlgruber, Moritz; Hartlieb, Sabine; Henrich, Kai-Oliver; Okonechnikov, Konstantin; Altmüller, Janine; Nürnberg, Peter; Lefever, Steve; De Wilde, Bram; Sand, Frederik; Ikram, Fakhera; Rosswog, Carolina; Fischer, Janina; Theissen, Jessica; Hertwig, Falk; Singhi, Aatur D.; Simon, Thorsten; Vogel, Wenzel; Perner, Sven; Krug, Barbara; Schmidt, Matthias; Rahmann, Sven; Achter, Viktor; Lang, Ulrich; Vokuhl, Christian; Ortmann, Monika; Büttner, Reinhard; Eggert, Angelika; Speleman, Frank; O’Sullivan, Roderick J.; Thomas, Roman K.; Berthold, Frank; Vandesompele, Jo; Schramm, Alexander; Westermann, Frank; Schulte, Johannes; Peifer, Martin; Fischer, Matthias

A mechanistic classification of clinical phenotypes in neuroblastoma

In: Science Vol. 362 (2018) Nr. 6419, pp. 1165 - 1170

ISSN: 1095-9203; 0036-8075

Online Full Text: dx.doi.org/
Grob, Jean Jacques; Garbe, Claus; Ascierto, Paolo; Larkin, James; Dummer, Reinhard; Schadendorf, Dirk

Adjuvant melanoma therapy with new drugs : should physicians continue to focus on metastatic disease or use it earlier in primary melanoma?

In: The Lancet Oncology Vol. 19 (2018) Nr. 12, pp. e720 - e725

ISSN: 1470-2045; 1474-5488

Online Full Text: dx.doi.org/
Eggermont, Alexander M.M.; Blank, Christian U.; Mandala, Mario; Long, Georgina V.; Atkinson, Victoria; Dalle, Stéphane; Haydon, Andrew; Lichinitser, Mikhail; Khattak, Adnan; Carlino, Matteo S.; Sandhu, Shahneen; Larkin, James; Puig, Susana; Ascierto, Paolo A.; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Maio, Michele; Van Den Eertwegh, Alfonsus J. M.; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; Lorigan, Paul; Ibrahim, Nageatte; Marreaud, Sandrine; Van Akkooi, Alexander C. J.; Suciu, Stefan; Robert, Caroline

Adjuvant pembrolizumab versus placebo in resected stage III melanoma

In: The New England Journal of Medicine Vol. 378 (2018) Nr. 19, pp. 1789 - 1801

ISSN: 1533-4406; 0028-4793

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Maio, Michele; Lewis, Karl; Demidov, Lev; Mandalà, Mario; Bondarenko, Igor; Ascierto, Paolo A; Herbert, Christopher; Mackiewicz, Andrzej; Rutkowski, Piotr; Guminski, Alexander; Goodman, Grant R; Simmons, Brian; Ye, Chenglin; Yan, Yibing; Schadendorf, Dirk; BRIM8 Investigators

Adjuvant vemurafenib in resected, BRAF mutation-positive melanoma (BRIM8) : a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial

In: The Lancet Oncology Vol. 19 (2018) Nr. 4, pp. 510 - 520

ISSN: 1470-2045; 1474-5488

Online Full Text: dx.doi.org/
Atkinson, Victoria G.; Hauschild, Axel; Santinami, Mario; Mandala, Mario; Chiarion Sileni, Vanna; Larkin, James M. G.; Nyakas, Marta S.; Dutriaux, Caroline; Haydon, Andrew M. M.; Mortier, Laurent; Robert, Caroline; Schachter, Jacob M.; Schadendorf, Dirk; Feng, X.; Jong, Egbert de; Mookerjee, Bijoyesh P.; Kefford, Rick F.; Dummer, Reinhard G.; Kirkwood, John M.; Long, Georgina V.

Adverse events (AEs) over time in patients (pts) treated with adjuvant dabrafenib plus trametinib (D + T) or placebo (Pbo) in the COMBI-AD trial

In: Annals of Oncology: official journal of the European Society for Medical Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii446

ISSN: 0923-7534; 1569-8041

Online Full Text: dx.doi.org/ (Open Access)
Kugel, Curtis H.; Douglass, Stephen M.; Webster, Marie R.; Kaur, Amanpreet; Liu, Qin; Yin, Xiangfan; Weiss, Sarah A.; Darvishian, Farbod; Al-Rohil, Rami N.; Ndoye, Abibatou; Behera, Reeti; Alicea, Gretchen M.; Ecker, Brett L.; Fane, Mitchell; Allegrezza, Michael J.; Svoronos, Nikolaos; Kumar, Vinit; Wang, Daniel Y.; Somasundaram, Rajasekharan; Hu-Lieskovan, Siwen; Ozgun, Alpaslan; Herlyn, Meenhard; Conejo-Garcia, Jose R.; Gabrilovich, Dmitry; Stone, Erica L.; Nowicki, Theodore S.; Sosman, Jeffrey; Rai, Rajat; Carlino, Matteo S.; Long, Georgina V.; Marais, Richard; Ribas, Antoni; Eroglu, Zeynep; Davies, Michael A.; Schilling, Bastian; Schadendorf, Dirk; Xu, Wei; Amaravadi, Ravi K.; Menzies, Alexander M.; McQuade, Jennifer L.; Johnson, Douglas B.; Osman, Iman; Weeraratna, Ashani T.

Age correlates with response to anti-PD1, reflecting age-related differences in intratumoral effector and regulatory T-Cell populations

In: Clinical Cancer Research Vol. 24 (2018) Nr. 21, pp. 5347 - 5356

ISSN: 1078-0432; 1557-3265

Online Full Text: dx.doi.org/
Lollies, Anna; Hartmann, Sylvia; Schneider, Markus; Bracht, Thilo; Weiß, A.L.; Arnolds, Judith; Klein-Hitpaß, Ludger; Sitek, Barbara; Hansmann, Martin Leo; Küppers, Ralf; Weniger, Marc

An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma

In: Leukemia Vol. 32 (2018) Nr. 1, pp. 92 - 101

ISSN: 0887-6924; 1476-5551

Online Full Text: dx.doi.org/
Gulbins, Anne; Schumacher, Fabian; Becker, Katrin Anne; Wilker, Barbara; Soddemann, Matthias; Boldrin, Francesco; Müller, Christian P.; Edwards, Michael J.; Goodman, Michael; Caldwell, Charles C.; Kleuser, Burkhard; Kornhuber, Johannes; Szabo, Ildiko; Gulbins, Erich

Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

In: Molecular Psychiatry Vol. 23 (2018) pp. 2324 - 2346

ISSN: 1476-5578; 1359-4184

Online Full Text: dx.doi.org/ (Open Access)
Gulbins, Anne; Schumacher, Fabian; Becker, Katrin Anne; Wilker, Barbara; Soddemann, Matthias; Boldrin, Francesco; Müller, Christian P.; Edwards, Michael J.; Goodman, Michael; Caldwell, Charles C.; Kleuser, Burkhard; Kornhuber, Johannes; Szabo, Ildiko; Gulbins, Erich

Antidepressants regulate autophagy by targeting acid sphingomyelinase

In: Molecular Psychiatry Vol. 23 (2018) Nr. 12, pp. 2251

ISSN: 1359-4184; 1476-5578

Online Full Text: dx.doi.org/
McQuade, Jennifer L; Daniel, Carrie R; Hess, Kenneth R; Mak, Carmen; Wang, Daniel Y; Rai, Rajat R; Park, John J; Haydu, Lauren E; Spencer, Christine; Wongchenko, Matthew; Lane, Stephen; Lee, Dung-Yang; Kaper, Mathilde; McKean, Meredith; Beckermann, Kathryn E; Rubinstein, Samuel M; Rooney, Isabelle; Musib, Luna; Budha, Nageshwar; Hsu, Jessie; Nowicki, Theodore S; Avila, Alexandre; Haas, Tomas; Puligandla, Maneka; Lee, Sandra; Fang, Shenying; Wargo, Jennifer A; Gershenwald, Jeffrey E; Lee, Jeffrey E; Hwu, Patrick; Chapman, Paul B; Sosman, Jeffrey A; Schadendorf, Dirk; Grob, Jean-Jacques; Flaherty, Keith T; Walker, Dana; Yan, Yibing; McKenna, Edward; Legos, Jeffrey J; Carlino, Matteo S; Ribas, Antoni; Kirkwood, John M; Long, Georgina V; Johnson, Douglas B; Menzies, Alexander M; Davies, Michael A

Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy : a retrospective, multicohort analysis

In: The Lancet Oncology Vol. 19 (2018) Nr. 3, pp. 310 - 322

ISSN: 1470-2045

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Gröbner, Susanne N; Worst, Barbara C; Weischenfeldt, Joachim; Buchhalter, Ivo; Kleinheinz, Kortine; Rudneva, Vasilisa A; Johann, Pascal D; Balasubramanian, Gnana Prakash; Segura-Wang, Maia; Brabetz, Sebastian; Bender, Sebastian; Hutter, Barbara; Sturm, Dominik; Pfaff, Elke; Hübschmann, Daniel; Zipprich, Gideon; Heinold, Michael; Eils, Jürgen; Lawerenz, Christian; Erkek, Serap; Lambo, Sander; Waszak, Sebastian; Blattmann, Claudia; Borkhardt, Arndt; Kuhlen, Michaela; Eggert, Angelika; Fulda, Simone; Gessler, Manfred; Wegert, Jenny; Kappler, Roland; Baumhoer, Daniel; Burdach, Stefan; Kirschner-Schwabe, Renate; Kontny, Udo; Kulozik, Andreas E; Lohmann, Dietmar; Hettmer, Simone; Eckert, Cornelia; Bielack, Stefan; Nathrath, Michaela; Niemeyer, Charlotte; Richter, Günther H; Schulte, Johannes; Siebert, Reiner; Westermann, Frank; Molenaar, Jan J; Vassal, Gilles; Witt, Hendrik; Burkhardt, Birgit; Kratz, Christian P; Witt, Olaf; van Tilburg, Cornelis M; Kramm, Christof M; Fleischhack, Gudrun; Dirksen, Uta; Rutkowski, Stefan; Frühwald, Michael; von Hoff, Katja; Wolf, Stephan; Klingebiel, Thomas; Koscielniak, Ewa; Landgraf, Pablo; Koster, Jan; Resnick, Adam C; Zhang, Jinghui; Liu, Yanling; Zhou, Xin; Waanders, Angela J; Zwijnenburg, Danny A; Raman, Pichai; Brors, Benedikt; Weber, Ursula D; Northcott, Paul A; Pajtler, Kristian; Kool, Marcel; Piro, Rosario M; Korbel, Jan O; Schlesner, Matthias; Eils, Roland; Jones, David T W; Lichter, Peter; Chavez, Lukas; Zapatka, Marc; Pfister, Stefan M; ICGC PedBrain-Seq Project; ICGC MMML-Seq Project

Author Correction : The landscape of genomic alterations across childhood cancers

In: Nature Vol. 559 (2018) Nr. 7714, pp. E10

ISSN: 0028-0836; 1476-4687

Online Full Text: dx.doi.org/
Tucci, Felicia A.; Kitanovski, Simo; Johansson, Patricia; Klein-Hitpaß, Ludger; Kahraman, Alisan; Dürig, Jan; Hoffmann, Daniel; Küppers, Ralf

Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individuals

In: Blood Vol. 131 (2018) Nr. 5, pp. 546 - 557

ISSN: 1528-0020; 0006-4971

Online Full Text: dx.doi.org/ (Open Access)
Goldschmidt, H.; Lokhorst, H.M.; Mai, E.K.; Van Der Holt, B.; Blau, I.W.; Zweegman, S.; Weisel, K.C.; Vellenga, E.; Pfreundschuh, M.; Kersten, M.J.; Scheid, C.; Croockewit, S.; Raymakers, R.; Hose, D.; Potamianou, A.; Jauch, A.; Hillengass, J.; Stevens-Kroef, M.; Raab, M.S.; Broijl, A.; Lindemann, H.W.; Bos, G.M.J.; Brossart, P.; Van Marwijk Kooy, M.; Ypma, P.; Dührsen, Ulrich; Schaafsma, R.M.; Bertsch, U.; Hielscher, T.; Jarari, Le; Salwender, H.J.; Sonneveld, P.

Bortezomib before and after high-dose therapy in myeloma : Long-term results from the phase III HOVON-65/GMMG-HD4 trial

In: Leukemia Vol. 32 (2018) Nr. 2, pp. 383 - 390

ISSN: 1476-5551; 0887-6924

Online Full Text: dx.doi.org/
Khairnar, Vishal; Duhan, Vikas; Patil, Ashwini M.; Zhou, Fan; Bhat, Hilal; Thoens, Christine; Sharma, Piyush; Adomati, Tom; Friendrich, Sarah-Kim; Bezgovsek, Judith; Dreesen, Janine D.; Wennemuth, Gunther; Westendorf, Astrid; Zelinskyy, Gennadiy; Dittmer, Ulf; Hardt, Cornelia; Timm, Jörg; Göthert, Joachim Rudolf; Lang, Philipp A.; Singer, Bernhard B.; Lang, Karl S.

CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infection

In: Nature Communications Vol. 9 (2018) pp. 2561

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Shukla, Sachet A.; Bachireddy, Pavan; Schilling, Bastian; Galonska, Christina; Zhan, Qian; Bango, Clyde; Langer, Rupert; Lee, Patrick C.; Gusenleitner, Daniel; Keskin, Derin B.; Babadi, Mehrtash; Mohammad, Arman; Gnirke, Andreas; Clement, Kendell; Cartun, Zachary J.; Van Allen, Eliezer M.; Miao, Diana; Huang, Ying; Snyder, Alexandra; Merghoub, Taha; Wolchok, Jedd D.; Garraway, Levi A.; Meissner, Alexander; Weber, Jeffrey S.; Hacohen, Nir; Neuberg, Donna; Potts, Patrick R.; Murphy, George F.; Lian, Christine G.; Schadendorf, Dirk; Hodi, F. Stephen; Wu, Catherine J.

Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade

In: Cell Vol. 173 (2018) Nr. 3, pp. 624 - 633.e8

ISSN: 1097-4172; 0092-8674

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Trusch, Franziska; Loebach, Lars; Wawra, Stephan; Durward, Elaine; Wuensch, Andreas; Iberahim, Nurul Aqilah; De Bruijn, Irene; MacKenzie, Kevin; Willems, Ariane; Toloczko, Aleksandra; Diéguez-Uribeondo, Javier; Rasmussen, Tim; Schrader, Thomas; Bayer, Peter; Secombes, Chris J.; Van West, Pieter

Cell entry of a host-targeting protein of oomycetes requires gp96

In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 2347

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Fan, Kaiji; Ritter, Cathrin; Nghiem, Paul; Blom, Astrid; Verhaegen, Monique E.; Dlugosz, Andrzej; Ødum, Niels; Woetmann, Anders; Tothill, Richard W.; Hicks, Rodney J.; Sand, Michael; Schrama, David; Schadendorf, Dirk; Ugurel, Selma; Becker, Jürgen C.

Circulating cell-free miR-375 as surrogate marker of tumor burden in Merkel cell carcinoma

In: Clinical Cancer Research Vol. 24 (2018) Nr. 23, pp. 5873 - 5882

ISSN: 1078-0432; 1557-3265

Online Full Text: dx.doi.org/
Kurtz, David M.; Scherer, Florian; Jin, Michael C.; Soo, Joanne; Craig, Alexander F.M.; Esfahani, Mohammad Shahrokh; Chabon, Jacob J.; Stehr, Henning; Liu, Chih Long; Tibshirani, Robert; Maeda, Lauren S.; Gupta, Neel K.; Khodadoust, Michael S.; Advani, Ranjana H.; Levy, Ronald; Newman, Aaron M.; Dührsen, Ulrich; Hüttmann, Andreas; Meignan, Michel; Casasnovas, René-Olivier; Westin, Jason R.; Roschewski, Mark; Wilson, Wyndham H.; Gaidano, Gianluca; Rossi, Davide; Diehn, Maximilian; Alizadeh, Ash A.

Circulating tumor DNA measurements as early outcome predictors in diffuse large B-Cell lymphoma

In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 28, pp. 2845 - 2853

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Lang, Stephan; Bruderek, Kirsten; Kaspar, Cordelia; Höing, Benedikt; Kanaan, Oliver; Dominas, Nina; Hussain, Timon; Droege, Freya; Eyth, Christian; Hadaschik, Boris; Brandau, Sven

Clinical Relevance and Suppressive Capacity of Human Myeloid-Derived Suppressor Cell Subsets

In: Clinical Cancer Research Vol. 24 (2018) Nr. 19, pp. 4834 - 4844

ISSN: 1078-0432; 1557-3265

Online Full Text: dx.doi.org/
ter Veer, Emil; van Rijssen, L. Bengt; Besselink, Marc G.; Mali, Rosa M. A.; Berlin, Jordan D.; Boeck, Stefan; Bonnetain, Franck; Chau, Ian; Conroy, Thierry; Van Cutsem, Eric; Deplanque, Gael; Friess, Helmut; Glimelius, Bengt; Goldstein, David; Herrmann, Richard; Labianca, Roberto; Van Laethem, Jean-Luc; Macarulla, Teresa; van der Meer, Jonathan H. M.; Neoptolemos, John P.; Okusaka, Takuji; O'Reilly, Eileen M.; Pelzer, Uwe; Philip, Philip A.; van der Poel, Marcel J.; Reni, Michele; Scheithauer, Werner; Siveke, Jens; Verslype, Chris; Busch, Olivier R.; Wilmink, Johanna W.; van Oijen, Martijn G. H.; van Laarhoven, Hanneke W. M.

Consensus statement on mandatory measurements in pancreatic cancer trials (COMM-PACT) for systemic treatment of unresectable disease

In: The Lancet Oncology Vol. 19 (2018) Nr. 3, pp. e151 - e160

ISSN: 1470-2045; 1474-5488

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Huckins, L.M.; Hatzikotoulas, K.; Southam, L.; Thornton, L.M.; Steinberg, J.; Aguilera-McKay, F.; Treasure, J.; Schmidt, U.; Gunasinghe, C.; Romero, A.; Curtis, C.; Rhodes, D.; Moens, J.; Kalsi, G.; Dempster, D.; Leung, R.; Keohane, A.; Burghardt, R.; Ehrlich, S.; Hebebrand, Johannes; Hinney, Anke; Ludolph, A.; Walton, E.; Deloukas, P.; Hofman, A.; Palotie, A.; Palta, P.; van Rooij, F.J.A.; Stirrups, K.; Adan, R.; Boni, C.; Cone, R.; Dedoussis, G.; van Furth, E.; Gonidakis, F.; Gorwood, P.; Hudson, J.; Kaprio, J.; Kas, M.; Keski-Rahonen, A.; Kiezebrink, K.; Knudsen, G-P; Maj, M.; Monteleone, A.M.; Monteleone, P.; Raevuori, A.H.; Reichborn-Kjennerud, T.; Tozzi, F.; Tsitsika, A.; van Elburg, A.; Collier, D.A.; Sullivan, P.F.; Breen, G.; Bulik, C.M.; Zeggini, E.

Correction: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

In: Molecular Psychiatry Vol. 23 (2018) Nr. 9, pp. 1

ISSN: 1476-5578; 1359-4184

Online Full Text: dx.doi.org/
Gharun, Kourosh; Senges, Julia; Seidl, Maximilian; Lösslein, Anne; Kolter, Julia; Lohrmann, Florens; Fliegauf, Manfred; Elgizouli, Magdeldin; Alber, Marco; Vavra, Martina; Schachtrup, Kristina; Illert, Anna L; Gilleron, Martine; Kirschning, Carsten Jürgen; Triantafyllopoulou, Antigoni; Henneke, Philipp

Corrigendum: Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells

In: EMBO Reports Vol. 19 (2018) Nr. 12, pp. e47190

ISSN: 1469-221X; 1469-3178

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Küppers, Ralf; Stevenson, Freda K.

Critical influences on the pathogenesis of follicular lymphoma

In: Blood Vol. 131 (2018) Nr. 21, pp. 2297 - 2306

ISSN: 1528-0020; 0006-4971

Online Full Text: dx.doi.org/
Capper, David; Jones, David T. W.; Sill, Martin; Hovestadt, Volker; Schrimpf, Daniel; Sturm, Dominik; Koelsche, Christian; Sahm, Felix; Chavez, Lukas; Reuss, David E.; Kratz, Annekathrin; Wefers, Annika K.; Huang, Kristin; Pajtler, Kristian; Schweizer, Leonille; Stichel, Damian; Olar, Adriana; Engel, Nils W.; Lindenberg, Kerstin; Harter, Patrick N.; Braczynski, Anne K.; Plate, Karl H.; Dohmen, Hildegard; Garvalov, Boyan K.; Coras, Roland; Hölsken, Annett; Hewer, Ekkehard; Bewerunge-Hudler, Melanie; Schick, Matthias; Fischer, Roger; Beschorner, Rudi; Schittenhelm, Jens; Staszewski, Ori; Wani, Khalida; Varlet, Pascale; Pages, Melanie; Temming, Petra; Lohmann, Dietmar; Selt, Florian; Witt, Hendrik; Milde, Till; Witt, Olaf; Aronica, Eleonora; Giangaspero, Felice; Rushing, Elisabeth; Scheurlen, Wolfram; Geisenberger, Christoph; Rodriguez, Fausto J.; Becker, Albert; Preusser, Matthias; Haberler, Christine; Bjerkvig, Rolf; Cryan, Jane; Farrell, Michael; Deckert, Martina; Hench, Jürgen; Frank, Stephan; Serrano, Jonathan; Kannan, Kasthuri; Tsirigos, Aristotelis; Brück, Wolfgang; Hofer, Silvia; Brehmer, Stefanie; Seiz-Rosenhagen, Marcel; Hänggi, Daniel; Hans, Volkmar; Rozsnoki, Stephanie; Hansford, Jordan R.; Kohlhof, Patricia; Kristensen, Bjarne W.; Lechner, Matt; Lopes, Beatriz; Mawrin, Christian; Ketter, Ralf; Kulozik, Andreas; Khatib, Ziad; Heppner, Frank; Koch, Arend; Jouvet, Anne; Keohane, Catherine; Mühleisen, Helmut; Mueller, Wolf; Pohl, Ute; Prinz, Marco; Benner, Axel; Zapatka, Marc; Gottardo, Nicholas G.; Driever, Pablo Hernáiz; Kramm, Christof M.; Müller, Hermann L.; Rutkowski, Stefan; Von Hoff, Katja; Frühwald, Michael C.; Gnekow, Astrid; Fleischhack, Gudrun; Tippelt, Stephan; Calaminus, Gabriele; Monoranu, Camelia-Maria; Perry, Arie; Jones, Chris; Jacques, Thomas S.; Radlwimmer, Bernhard; Gessi, Marco; Pietsch, Torsten; Schramm, Johannes; Schackert, Gabriele; Westphal, Manfred; Reifenberger, Guido; Wesseling, Pieter; Weller, Michael; Collins, Vincent Peter; Blümcke, Ingmar; Bendszus, Martin; Debus, Jürgen; Huang, Annie; Jabado, Nada; Northcott, Paul A.; Paulus, Werner; Gajjar, Amar; Robinson, Giles W.; Taylor, Michael D.; Jaunmuktane, Zane; Ryzhova, Marina; Platten, Michael; Unterberg, Andreas; Wick, Wolfgang; Karajannis, Matthias A.; Mittelbronn, Michel; Acker, Till; Hartmann, Christian; Aldape, Kenneth; Schüller, Ulrich; Buslei, Rolf; Lichter, Peter; Kool, Marcel; Herold-Mende, Christel; Ellison, David W.; Hasselblatt, Martin; Snuderl, Matija; Brandner, Sebastian; Korshunov, Andrey; Von Deimling, Andreas; Pfister, Stefan M.

DNA methylation-based classification of central nervous system tumours

In: Nature Vol. 555 (2018) Nr. 7697, pp. 469 - 474

ISSN: 0028-0836; 1476-4687

Online Full Text: dx.doi.org/ (Open Access)
Lee, K.; Bodoky, Gyorgy; Blanc, Jean Frédéric; Siveke, Jens; Macarulla Mercade, T.; Wang-Gillam, Andrew; Chen, L.; Mirakhur, Beloo; Chen, Jie; Jong, Floris A. de

Decreased appetite (DA) at baseline impacts prognosis in the NAPOLI-1 phase 3 study in metastatic pancreatic ductal adenocarcinoma (mPDAC)

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 5, pp. v42 - v43

ISSN: 0923-7534; 1569-8041

Online Full Text: dx.doi.org/ (Open Access)
Bogner, Simon; Schmid, Kurt Werner; Metzenmacher, Martin; Hager, Thomas; Herrmann, Ken; Walter, Robert; Hegedues, Balazs; Herold, Thomas; Eberhardt, Wilfried; Reis, Henning; Goetz, Moritz; Mairinger, Fabian Dominik; Wiesweg, Marcel; Darwiche, Kaid; Aigner, Clemens; Schuler, Martin

Development of predictors for PD-1/PD-L1-directed therapy of non-small cell lung cancer (NSCLC) by gene expression profiling of small diagnostic biopsies (DBX)

In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 15 Suppl., pp. e15121

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Wohlgemuth, Roland; Littlechild, Jennifer; Monti, Daniela; Schnorr, Kirk; van Rossum, Teunke; Siebers, Bettina; Menzel, Peter; Kublanov, Ilya V.; Rike, Anne Gunn; Skretas, Georgios; Szabo, Zalan; Peng, Xu; Young, Mark J.

Discovering novel hydrolases from hot environments

In: Biotechnology Advances Vol. 36 (2018) Nr. 8, pp. 2077 - 2100

ISSN: 0734-9750; 1873-1899

Online Full Text: dx.doi.org/ (Open Access)
Langer, Samantha K; Cull, Alyssa; Wossidlo, Natalie; Klump, Hannes; Horn, Peter; Heinrichs, Stefan;

Distinct Gene Expression Patterns Drive Proliferation of Dominant-Negative RUNX1 Immortalized HSPCs
60th ASH Annual Meeting; December 1-4, 2018; San Diego, USA,

In: Blood Vol. 132 (2018) Nr. Supplement 1, pp. 1795 - 1795

ISSN: 1528-0020; 0006-4971

Online Full Text: dx.doi.org/
Schult, Frank; Le, Thuong N.; Albersmeier, Andreas; Rauch, Bernadette; Blumenkamp, Patrick; Van Der Does, Chris; Goesmann, Alexander; Kalinowski, Jörn; Albers, Sonja-Verena; Siebers, Bettina

Effect of UV irradiation on Sulfolobus acidocaldarius and involvement of the general transcription factor TFB3 in the early UV response

In: Nucleic Acids Research Vol. 46 (2018) Nr. 14, pp. 7179 - 7192

ISSN: 1362-4962; 0301-5610; 0305-1048

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS) : a multicentre, open-label, randomised phase 3 trial

In: The Lancet Oncology Vol. 19 (2018) Nr. 5, pp. 603 - 615

ISSN: 1470-2045; 1474-5488

Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
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Estimate of long-term relapse-free survival (RFS) and analysis of baseline factors associated with RFS in the COMBI-AD trial

In: Annals of Oncology: official journal of the European Society for Medical Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii445

ISSN: 0923-7534; 1569-8041

Online Full Text: dx.doi.org/ (Open Access)
Shen, Bin; Tatchen, Jörg; Sanchez-Garcia, Elsa; Bettinger, Holger F.

Evolution of the Optical Gap in the Acene Series : Undecacene

In: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 33, pp. 10506 - 10509

ISSN: 1521-3773; 1433-7851

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Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors

In: Nature Genetics Vol. 50 (2018) Nr. 9, pp. 1271 - 1281

ISSN: 1061-4036; 1546-1718

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Moonens, Kristof; Hamway, Youssef; Neddermann, Matthias; Reschke, Marc; Tegtmeyer, Nicole; Kruse, Tobias; Kammerer, Robert; Mejías-Luque, Raquel; Singer, Bernhard B.; Backert, Steffen; Gerhard, Markus; Remaut, Han

Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs

In: The EMBO Journal Vol. 37 (2018) Nr. 13,

ISSN: 1460-2075; 0261-4189

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Pfeifer, Wolfgang; Lill, Pascal; Gatsogiannis, Christos; Sacca, Barbara

Hierarchical Assembly of DNA Filaments with Designer Elastic Properties

In: ACS Nano Vol. 12 (2018) Nr. 1, pp. 44 - 55

ISSN: 1936-086X; 1936-0851

Online Full Text: dx.doi.org/
Wagener, Rabea; López, Cristina; Kleinheinz, Kortine; Bausinger, Julia; Aukema, Sietse M.; Nagel, Inga; Toprak, Umut H.; Seufert, Julian; Altmüller, Janine; Thiele, Holger; Schneider, Christof; Kolarova, Julia; Park, Jeongbin; Hübschmann, Daniel; Murga Penas, Eva M.; Drexler, Hans G.; Attarbaschi, Andishe; Hovland, Randi; Kjeldsen, Eigil; Kneba, Michael; Kontny, Udo; de Leval, Laurence; Nürnberg, Peter; Oschlies, Ilske; Oscier, David; Schlegelberger, Brigitte; Stilgenbauer, Stephan; Wössmann, Wilhelm; Schlesner, Matthias; Burkhardt, Birgit; Klapper, Wolfram; Jaffe, Elaine S.; Küppers, Ralf; Siebert, Reiner

IG-MYC⁺ neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas

In: Blood Vol. 132 (2018) Nr. 21, pp. 2280 - 2285

ISSN: 1528-0020

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Mahabadi, Amir Abbas; Rassaf, Tienush

Imaging of coronary inflammation for cardiovascular risk prediction

In: The Lancet Vol. 392 (2018) Nr. 10151, pp. 894 - 896

ISSN: 1474-547X; 0140-6736

Online Full Text: dx.doi.org/ (Open Access)
Chen, Li Tzon; Macarulla, Teresa M.; Blanc, Jean Frédéric; Mirakhur, Beloo; Jong, Floris A. de; Belanger, Bruce; Bekaii-Saab, Tanios; Siveke, Jens

Impact of dose reduction or dose delay on the efficacy of liposomal irinotecan (nal-IRI)+5-fluorouracil/leucovorin (5-FU/LV) : Survival analysis from NAPOLI-1

In: Annals of Oncology: official journal of the European Society for Medical Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii250 - viii251

ISSN: 0923-7534; 1569-8041

Online Full Text: dx.doi.org/ (Open Access)
Knüppel, Robert; Christensen, Regitse H; Gray, Fiona C; Esser, Dominik; Strauß, Daniela; Medenbach, Jan; Siebers, Bettina; MacNeill, Stuart A; LaRonde, Nicole; Ferreira-Cerca, Sébastien

Insights into the evolutionary conserved regulation of Rio ATPase activity.

In: Nucleic Acids Research Vol. 46 (2018) Nr. 3, pp. 1441 - 1456

ISSN: 1362-4962; 0301-5610; 0305-1048

Online Full Text: dx.doi.org/ (Open Access)
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Integrated genomic classification of melanocytic tumors of the central nervous system using mutation analysis, copy number alterations, and DNA methylation profiling

In: Clinical Cancer Research Vol. 24 (2018) Nr. 18, pp. 4494 - 4504

ISSN: 1078-0432; 1557-3265

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Huckins, L.M.; Hatzikotoulas, K.; Southam, L.; Thornton, L.M.; Steinberg, J.; Aguilera-Mckay, F.; Treasure, J.; Schmidt, U.; Gunasinghe, C.; Romero, A.; Curtis, C.; Rhodes, D.; Moens, J.; Kalsi, G.; Dempster, D.; Leung, R.; Keohane, A.; Burghardt, R.; Ehrlich, S.; Hebebrand, Johannes; Hinney, Anke; Ludolph, A.; Walton, E.; Deloukas, P.; Hofman, A.; Palotie, A.; Palta, P.; Van Rooij, F.J.A.; Stirrups, K.; Adan, R.; Boni, C.; Cone, R.; Dedoussis, G.; Van Furth, E.; Gonidakis, F.; Gorwood, P.; Hudson, J.; Kaprio, J.; Kas, M.; Keski-Rahonen, A.; Kiezebrink, K.; Knudsen, G.-P.; Slof-Op 'T Landt, M.C.T.; Maj, M.; Monteleone, A.M.; Monteleone, P.; Raevuori, A.H.; Reichborn-Kjennerud, T.; Tozzi, F.; Tsitsika, A.; Van Elburg, A.; Collier, D.A.; Sullivan, P.F.; Breen, G.; Bulik, C.M.; Zeggini, E.

Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

In: Molecular Psychiatry Vol. 23 (2018) Nr. 5, pp. 1169 - 1180

ISSN: 1476-5578; 1359-4184

Online Full Text: dx.doi.org/ (Open Access)
Hauschild, Axel; Dummer, Reinhard; Schadendorf, Dirk; Santinami, Mario; Atkinson, Victoria; Mandalà, Mario; Chiarion-Sileni, Vanna; Larkin, James; Nyakas, Marta; Dutriaux, Caroline; Haydon, Andrew; Robert, Caroline; Mortier, Laurent; Schachter, Jacob; Lesimple, Thierry; Plummer, Ruth; Dasgupta, Kohinoor; Haas, Tomas; Shilkrut, Mark; Gasal, Eduard; Kefford, Richard; Kirkwood, John M.; Long, Georgina V.

Longer Follow-Up Confirms Relapse-Free Survival Benefit With Adjuvant Dabrafenib Plus Trametinib in Patients With Resected BRAF V600–Mutant Stage III Melanoma

In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 35, pp. 3441 - 3449

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/ (Open Access)
Platzbecker, Uwe; Middeke, Jan Moritz; Sockel, Katja; Herbst, Regina; Wolf, Dominik; Baldus, Claudia D.; Oelschlägel, Uta; Mütherig, Anke; Fransecky, Lars; Noppeney, Richard; Bug, Gesine; Götze, Katharina S.; Krämer, Alwin; Bochtler, Tilmann; Stelljes, Matthias; Groth, Christoph; Schubert, Antje; Mende, Marika; Stölzel, Friedrich; Borkmann, Christine; Kubasch, Anne Sophie; von Bonin, Malte; Serve, Hubert; Hänel, Mathias; Dührsen, Ulrich; Schetelig, Johannes; Röllig, Christoph; Kramer, Michael; Ehninger, Gerhard; Bornhäuser, Martin; Thiede, Christian

Measurable residual disease-guided treatment with azacitidine to prevent haematological relapse in patients with myelodysplastic syndrome and acute myeloid leukaemia (RELAZA2) : an open-label, multicentre, phase 2 trial

In: The Lancet Oncology Vol. 19 (2018) Nr. 12, pp. 1668 - 1679

ISSN: 1470-2045; 1474-5488

Online Full Text: dx.doi.org/
Schadendorf, Dirk; Van Akkooi, Alexander; Berking, Carola; Griewank, Klaus; Gutzmer, Ralf; Hauschild, Axel; Stang, Andreas; Rösch, Alexander; Ugurel, Selma

Melanoma

In: The Lancet Vol. 392 (2018) Nr. 10151, pp. 971 - 984

ISSN: 0140-6736; 1474-547X

Online Full Text: dx.doi.org/
Kahaly, George J; Riedl, Michaela; König, Jochem; Pitz, Susanne; Ponto, Katharina; Diana, Tanja; Kampmann, Elena; Kolbe, Elisa; Eckstein, Anja; Möller, Lars; Führer, Dagmar; Salvi, Mario; Curro, Nicola; Campi, Irene; Covelli, Danila; Leo, Marenza; Marinò, Michele; Menconi, Francesca; Marcocci, Claudio; Bartalena, Luigi; Perros, Petros; Wiersinga, Wilmar M; Ayvaz, Göksun; Baldeschi, Lelio; Boborides, Kostas; Boschi, Antonella; Brix, Thomas H; Clarke, Lucy; Dayan, Colin; Daumerie, Chantal; Dickinson, A Jane; Fichter, Nicole; Hegedüs, Laszlo; Konuk, Onur; Krassas, Gerassimos E; Lane, Carol; Lazarus, John; Morris, Dan S; Mourits, Maarten; Nardi, Marco; Neoh, Chris; Orgiazzi, Jacques; Pearce, Simon H S; von Arx, Georg; Zarkovic, Milos

Mycophenolate plus methylprednisolone versus methylprednisolone alone in active, moderate-to-severe Graves' orbitopathy (MINGO) : a randomised, observer-masked, multicentre trial

In: The Lancet Diabetes and Endocrinology Vol. 6 (2018) Nr. 4, pp. 287 - 298

ISSN: 2213-8595; 2213-8587

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Macarulla Mercade, Teresa; Bodoky, Gyorgy; Siveke, Jens; Lee, Kyung-hun; Chen, J.; Mirakhur, Beloo; Dean, Andrew; Chen, Li-Tzong; Jong, Floris A. de

NAPOLI-1 phase III trial outcomes by prior surgery, and disease stage, in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC)

In: Annals of Oncology: official journal of the European Society for Medical Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii249 - viii250

ISSN: 0923-7534; 1569-8041

Online Full Text: dx.doi.org/ (Open Access)
Westmeier, Dana; Hahlbrock, Angelina; Reinhardt, Christoph; Fröhlich-Nowoisky, Janine; Wessler, Silja; Vallet, Cecilia; Pöschl, Ulrich; Knauer, Shirley; Stauber, Roland H.

Nanomaterial-microbe cross-talk : physicochemical principles and (patho)biological consequences

In: Chemical Society Reviews Vol. 47 (2018) Nr. 14, pp. 5312 - 5337

ISSN: 1460-4744; 0306-0012

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Hodi, Frank Stephen; Chiarion-Sileni, Vanna; Gonzalez, Rene; Grob, Jean-Jacques; Rutkowski, Piotr; Cowey, Charles Lance; Lao, Christopher D; Schadendorf, Dirk; Wagstaff, John; Dummer, Reinhard; Ferrucci, Pier Francesco; Smylie, Michael; Hill, Andrew; Hogg, David; Marquez-Rodas, Ivan; Jiang, Joel; Rizzo, Jasmine; Larkin, James; Wolchok, Jedd D

Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067) : 4-year outcomes of a multicentre, randomised, phase 3 trial

In: The Lancet Oncology Vol. 19 (2018) Nr. 11, pp. 1480 - 1492

ISSN: 1474-5488; 1470-2045

Online Full Text: dx.doi.org/
Cheung, Phyllis F.; Neff, Florian; Neander, Christian; Bazarna, Anna; Savvatakis, Konstantinos; Liffers, Sven-Thorsten; Althoff, Kristina; Lee, Chang-Lung; Moding, Everett J.; Kirsch, David G.; Saur, Dieter; Bazhin, Alexandr V.; Trajkovic-Arsic, Marija; Heikenwalder, Mathias F.; Siveke, Jens

Notch-induced myeloid reprogramming in spontaneous pancreatic ductal adenocarcinoma by dual genetic targeting

In: Cancer Research Vol. 78 (2018) Nr. 17, pp. 4997 - 5010

ISSN: 0008-5472; 1538-7445

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Mangolini, Maurizio; Götte, Frederik; Moore, Andrew; Ammon, Tim; Oelsner, Madlen; Lutzny-Geier, Gloria; Klein-Hitpaß, Ludger; Williamson, James C.; Lehner, Paul J.; Dürig, Jan; Möllmann, Michael; Rásó-Barnett, Lívia; Hughes, Katherine; Santoro, Antonella; Méndez-Ferrer, Simón; Oostendorp, Robert A. J.; Zimber-Strobl, Ursula; Peschel, Christian; Hodson, Daniel J.; Schmidt-Supprian, Marc; Ringshausen, Ingo

Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia

In: Nature Communications Vol. 9 (2018) pp. 3839

ISSN: 2041-1723

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Duffy, David L.; Zhu, Gu; Li, Xin; Sanna, Marianna; Iles, Mark M.; Jacobs, Leonie C.; Evans, David M.; Yazar, Seyhan; Beesley, Jonathan; Law, Matthew H.; Kraft, Peter; Visconti, Alessia; Taylor, John C.; Lui, Fan; Wright, Margaret J.; Henders, Anjali K.; Bowdler, Lisa; Glass, Dan; Ikram, Arfan M.; Uitterlinden, André G.; Madden, Pamela A.; Heath, Andrew C.; Nelson, Elliot C.; Green, Adele C.; Chanock, Stephen; Barrett, Jennifer H.; Brown, Matthew A.; Hayward, Nicholas K.; MacGregor, Stuart; Sturm, Richard A.; Hewitt, Alex W.; Lee, Jeffrey E.; Brossard, Myriam; Moses, Eric K.; Song, Fengju; Kumar, Rajiv; Easton, Douglas F.; Pharoah, Paul D. P.; Swerdlow, Anthony J.; Kypreou, Katerina P.; Harland, Mark; Randerson-Moor, Juliette; Akslen, Lars A.; Andresen, Per A.; Avril, Marie-Françoise; Azizi, Esther; Scarrà, Giovanna Bianchi; Brown, Kevin M.; Dębniak, Tadeusz; Elder, David E.; Fang, Shenying; Friedman, Eitan; Galan, Pilar; Ghiorzo, Paola; Gillanders, Elizabeth M.; Goldstein, Alisa M.; Gruis, Nelleke A.; Hansson, Johan; Helsing, Per; Hočevar, Marko; Höiom, Veronica; Ingvar, Christian; Kanetsky, Peter A.; Chen, Wei V.; Landi, Maria Teresa; Lang, Julie; Lathrop, G. Mark; Lubiński, Jan; Mackie, Rona M.; Mann, Graham J.; Molven, Anders; Novaković, Srdjan; Olsson, Håkan; Puig, Susana; Puig-Butille, Joan Anton; Radford-Smith, Graham L.; van der Stoep, Nienke; van Doorn, Remco; Whiteman, David C.; Craig, Jamie E.; Schadendorf, Dirk; Simms, Lisa A.; Burdon, Kathryn P.; Nyholt, Dale R.; Pooley, Karen A.; Orr, Nicholas; Stratigos, Alexander J.; Cust, Anne E.; Ward, Sarah V.; Schulze, Hans-Joachim; Dunning, Alison M.; Demenais, Florence; Amos, Christopher I.; Kayser, Manfred; Hunter, David J.; Newton Bishop, Julia A.; Spector, Timothy D.; Montgomery, Grant W.; Mackey, David A.; Smith, George Davey; Nijsten, Tamar E.; Bishop, D. Timothy; Bataille, Veronique; Falchi, Mario; Han, Jiali; Martin, Nicholas G.

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 4774

ISSN: 2041-1723

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Hodi, Frank S.; Chiarion-Sileni, Vanna; Gonzalez, René C.; Grob, Jean J.; Rutkowski, Piotr; Cowey, Charles L.; Lao, Christopher D.; Schadendorf, Dirk; Wagstaff, John; Dummer, Reinhard G.; Ferrucci, Pier F.; Smylie, Michael; Hill, A. G.; Hogg, David; Márquez-Rodas, Iván; Jiang, Joel; Rizzo, Jasmine I.; Larkin, James M. G.; Wolchok, J.

Overall survival at 4 years of follow-up in a phase III trial of nivolumab plus ipilimumab combination therapy in advanced melanoma (CheckMate 067)

In: Annals of Oncology: official journal of the European Society for Medical Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii735

ISSN: 0923-7534; 1569-8041

Online Full Text: dx.doi.org/ (Open Access)
Dummer, Reinhard; Ascierto, Paolo A.; Gogas, Helen J.; Arance, Ana; Mandala, Mario; Liszkay, Gabriella; Garbe, Claus; Schadendorf, Dirk; Krajsova, Ivana; Gutzmer, Ralf; Chiarion Sileni, Vanna; Dutriaux, Caroline; de Groot, Jan Willem B.; Yamazaki, Naoya; Loquai, Carmen; Moutouh-de Parseval, Laure A.; Pickard, Michael D.; Sandor, Victor; Robert, Caroline; Flaherty, Keith T.

Overall survival in patients with BRAF-mutant melanoma receiving encorafenib plus binimetinib versus vemurafenib or encorafenib (COLUMBUS) : a multicentre, open-label, randomised, phase 3 trial

In: The Lancet Oncology Vol. 19 (2018) Nr. 10, pp. 1315 - 1327

ISSN: 1470-2045; 1474-5488

Online Full Text: dx.doi.org/
Larkin, James; Minor, David; D'Angelo, Sandra; Neyns, Bart; Smylie, Michael; Miller, Wilson H.; Gutzmer, Ralf; Linette, Gerald; Chmielowski, Bartosz; Lao, Christopher D.; Lorigan, Paul; Grossmann, Kenneth; Hassel, Jessica C.; Sznol, Mario; Daud, Adil; Sosman, Jeffrey; Khushalani, Nikhil; Schadendorf, Dirk; Hoeller, Christoph; Walker, Dana; Kong, George; Horak, Christine; Weber, Jeffrey

Overall survival in patients with advanced melanoma who received nivolumab versus investigator's choice chemotherapy in CheckMate 037 : A Randomized, Controlled, Open-Label Phase III Trial

In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 4, pp. 383 - 390

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Migden, Michael R.; Rischin, Danny; Schmults, Chrysalyne D.; Guminski, Alexander; Hauschild, Axel; Lewis, Karl D.; Chung, Christine H.; Hernandez-Aya, Leonel; Lim, Annette M.; Chang, Anne Lynn S.; Rabinowits, Guilherme; Thai, Alesha A.; Dunn, Lara A.; Hughes, Brett G.M.; Khushalani, Nikhil I.; Modi, Badri; Schadendorf, Dirk; Gao, Bo; Seebach, Frank; Li, Siyu; Li, Jingjin; Mathias, Melissa; Booth, Jocelyn; Mohan, Kosalai; Stankevich, Elizabeth; Babiker, Hani M.; Brana, Irene; Gil-Martin, Marta; Homsi, Jade; Johnson, Melissa L.; Moreno, Victor; Niu, Jiaxin; Owonikoko, Taofeek K.; Papadopoulos, Kyriakos P.; Yancopoulos, George D.; Lowy, Israel; Fury, Matthew G.

PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma

In: The New England Journal of Medicine Vol. 379 (2018) Nr. 4, pp. 341 - 351

ISSN: 0028-4793; 1533-4406

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Ribas, Antoni; Robert, Caroline; Squires, Matthew; Schadendorf, Dirk; Davies, Michael A.; Nathan, Paul D.; Tan, Puay; Powell, William; Jaeger, Savina; Grob, Jean Jacques; Flaherty, Keith; Long, Georgina V.

PD-L1 and CD8 expression and association with outcomes in patients (pts) with BRAF V600E/K–mutant metastatic melanoma (MM) who received dabrafenib + trametinib (D+T) in the randomized phase 3 COMBI-v study.

In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 5 Suppl., pp. 183

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Juric, Dejan; Rodon, Jordi; Tabernero, Josep; Janku, Filip; Burris, Howard A.; Schellens, Jan H.M.; Middleton, Mark R.; Berlin, Jordan; Schuler, Martin; Marta, Gil-Martin; Rugo, Hope S.; Ruth, Seggewiss-Bernhardt; Huang, Alan; Bootle, Douglas; Demanse, David; Blumenstein, Lars; Coughlin, Christina; Quadt, Cornelia; Baselga, José

Phosphatidylinositol 3-kinase a–selective inhibition with alpelisib (BYL719) in PIK3CA-altered solid tumors : Results from the first-in-human study

In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 13, pp. 1291 - 1299

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Dührsen, Ulrich; Müller, Stefan; Hertenstein, Bernd; Thomssen, Henrike; Kotzerke, Jörg; Mesters, Rolf; Berdel, Wolfgang E.; Franzius, Christiane; Kroschinsky, Frank; Weckesser, Matthias; Kofahl-Krause, Dorothea; Bengel, Frank M.; Dürig, Jan; Matschke, Johannes; Schmitz, Christine; Pöppel, Thorsten; Ose, Claudia; Brinkmann, Marcus; La Rosée, Paul; Freesmeyer, Martin; Hertel, Andreas; Höffkes, Heinz-Gert; Behringer, Dirk; Prange-Krex, Gabriele; Wilop, Stefan; Krohn, Thomas; Holzinger, Jens; Griesshammer, Martin; Giagounidis, Aristoteles; Raghavachar, Aruna; Maschmeyer, Georg; Brink, Ingo; Bernhard, Helga; Haberkorn, Uwe; Gaska, Tobias; Kurch, Lars; Van Assema, Daniëlle M.E.; Klapper, Wolfram; Hoelzer, Dieter; Geworski, Lilli; Jöckel, Karl-Heinz; Scherag, Andre; Bockisch, Andreas; Rekowski, Jan; Hüttmann, Andreas

Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin Lymphomas (PETAL) : A Multicenter, Randomized Phase III Trial

In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 20, pp. 2024 - 2034

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Lakatos, Gábor; Lee, K.; Siveke, Jens; Blanc, Jean Frédéric; Macarulla Mercadé, Teresa; Dean, Andrew; Bodoky, Gyorgy; Mirakhur, Beloo; Chen, Jie; Wang-Gillam, Andrea; Chen, Li Li; Jong, Floris A. de

Prognostic value of baseline biliary stents on outcomes in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) in the NAPOLI-1 trial

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 5, pp. v42

ISSN: 1569-8041; 0923-7534

Online Full Text: dx.doi.org/ (Open Access)
Pesenti, Marion E; Prumbaum, Daniel; Auckland, Philip; Smith, Charlotte M; Faesen, Alex C; Petrovic, Arsen; Erent, Muriel; Maffini, Stefano; Pentakota, Satyakrishna; Weir, John R; Lin, Yu-Chih; Raunser, Stefan; McAinsh, Andrew D; Musacchio, Andrea

Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80.

In: Molecular Cell Vol. 71 (2018) Nr. 6, pp. 923 - 939.e10

ISSN: 1097-4164; 1097-2765

Online Full Text: dx.doi.org/ (Open Access)
Dührsen, Ulrich; Müller, Stefan; Rekowski, Jan; Hüttmann, Andreas

Reply to H.J.A adams et al and C. Gisselbrecht

In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 32, pp. 3273 - 3274

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Schadendorf, Dirk; Jiang, Joel; Kelleher, Thomas; Postow, Michael A.

Reply to M. Horiguchi et al [Patients With Advanced Melanoma Who Discontinued Treatment With Nivolumab and Ipilimumab as a Result of Adverse Events Lived Significantly Longer Than Patients Who Continued Treatment]

In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 7, pp. 721

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Sayehli, Cyrus; Nogova, Lucia; Nogai, Hendrik; Park, Se Hoon; Richly, Heike; Cathomas, Richard; Wermke, Martin; Bender, Sebastian; Navarro, Alejandra; Schostak, Martin; Grande, Enrique; Cassier, Philippe; Janitzky, Andreas; Penel, Nicolas; Ellinghaus, Peter; Tai, David Wai-Meng; Gillessen, Silke; Grüllich, Carsten; Joerger, Markus; Schuler, Martin

Rogaratinib treatment of patients with advanced urothelial carcinomas prescreened for tumor FGFR mRNA expression.

In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 6 Suppl., pp. 494

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Bezrookove, Vladimir; Nosrati, Mehdi; Miller, James R.; De Semir, David; Dar, Altaf A.; Vosoughi, Elham; Vaquero, Edith; Sucker, Antje; Lazar, Alexander J.; Gershenwald, Jeffrey E.; Davies, Michael A.; Schadendorf, Dirk; Kashani-Sabet, Mohammed

Role of elevated PHIP copy number as a prognostic and progression marker for cutaneous melanoma

In: Clinical Cancer Research Vol. 24 (2018) Nr. 17, pp. 4119 - 4125

ISSN: 1557-3265; 1078-0432

Online Full Text: dx.doi.org/
Jockenhöfer, Finja; Schimming, Tobias T.; Schaller, Jörg; Moege, Jürgen; Livingstone, Elisabeth; Salva, Katrin A.; Zimmer, Lisa; Schadendorf, Dirk; Rösch, Alexander

Sebaceous tumours: more than skin deep

In: Gut Vol. 67 (2018) Nr. 11, pp. 2045 - 2053

ISSN: 0017-5749; 1468-3288

Online Full Text: dx.doi.org/
Stauber, Roland H.; Siemer, Svenja; Becker, Sven; Ding, Guo-Bin; Strieth, Sebastian; Knauer, Shirley

Small Meets Smaller : Effects of Nanomaterials on Microbial Biology, Pathology, and Ecology

In: ACS Nano Vol. 12 (2018) Nr. 7, pp. 6351 - 6359

ISSN: 1936-086X; 1936-0851

Online Full Text: dx.doi.org/
Becker-Flegler, Katrin; Riethmüller, Joachim; Seitz, Aaron P.; Gardner, Aaron; Boudreau, Ryan; Kamler, Markus; Kleuser, Burkhard; Schuchman, Edward; Caldwell, Charles C.; Edwards, Michael J.; Grassmé, Heike; Brodlie, Malcolm; Gulbins, Erich

Sphingolipids as targets for inhalation treatment of cystic fibrosis

In: Advanced Drug Delivery Reviews Vol. 133 (2018) pp. 66 - 75

ISSN: 1872-8294; 0169-409X

Online Full Text: dx.doi.org/
Macarulla, T. M.; Hubner, R.; Blanc, J. F.; Wang-Gillam, A.; Li, C. P.; Bodoky, G.; Dean, A. P.; Yanshen, S.; Jameson, G. S.; Lee, K. H.; Chiu, C. F.; Schwartsmann, G.; Braiteh, F. S.; Cunningham, D.; Chen, L. T.; Von Hoff, D. D.; Mamlouk, K. K.; de Jong, F. A.; Siveke, Jens

Subgroup analysis by baseline (BL) weight-associated parameters : A phase III study of liposomal irinotecan (nal-IRI)+/--5fluorouracil/leucovorin (5-FU/LV) in patients (pts) with metastatic pancreatic ductal adenocarcinoma (mPDAC) previously treated with g

In: Journal of Clinical Oncology Vol. 36 (2018) Nr. Suppl. 4, pp. 410

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Macarulla, T. M.; Siveke, Jens; Dean, A. P.; Hubner, R.; Blanc, J. F.; Cunningham, D.; Chen, L. T.; Mirakhur, B.; Chen, J.; de Jong, F. A.; Wang-Gillam, A.

Subgroup analysis by baseline pain intensity (BPI) and analgesic use (BAU) in NAPOLI-1 : A phase III study of liposomal irinotecan (nal IRI)+/- 5-fluorouracil/leucovorin (5-FU/LV) in patients (pts) with metastatic pancreatic ductal adenocarcinoma (mPDAC) p

In: Journal of Clinical Oncology Vol. 36 (2018) Nr. Suppl. 4, pp. 379

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Siveke, Jens; Hubner, R.; Macarulla, T. M.; Wang-Gillam, A.; Dean, A. P.; Blanc, J. F.; Cunningham, D.; Mirakhur, B.; Belanger, B.; de Jong, F. A.; Chen, L. T.

Subgroup analysis by measurable metastatic lesion (ML) number and selected lesion locations (LL) at baseline (BL) in NAPOLI-1 : A phase III study of liposomal irinotecan (nal-IRI)+/- 5-fluorouracil/leucovorin (5-FU/LV) in patients (pts) with metastatic pan

In: Journal of Clinical Oncology Vol. 36 (2018) Nr. Suppl. 4, pp. 460

ISSN: 0732-183X; 1527-7755

Online Full Text: dx.doi.org/
Weske, Sarah; Vaidya, Mithila; Reese, Alina; Von Wnuck Lipinski, Karin; Keul, Petra; Bayer, Julia K; Fischer, Jens W; Flögel, Ulrich; Nelsen, Jens; Epple, Matthias; Scatena, Marta; Schwedhelm, Edzard; Dörr, Marcus; Völzke, Henry; Moritz, Eileen; Hannemann, Anke; Rauch, Bernhard H; Gräler, Markus H; Heusch, Gerd; Levkau, Bodo

Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss

In: Nature Medicine Vol. 24 (2018) Nr. 5, pp. 667 - 678

ISSN: 1546-170X; 1078-8956

Online Full Text: dx.doi.org/
Macurulla Mercade, Teresa; Wang-Gillam, Andrea; Chen, L.; Blanc, Jean Frédéric; Lee, K.; Bodoky, Gyorgy; Dean, Andrew; Chen, Jie; Mirakhur, Beloo; Siveke, Jens; de Jong, Floris A.

The effect of best response to prior anticancer therapy on efficacy outcomes in the NAPOLI-1 trial of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) previously treated with gemcitabine-based therapy

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 5, pp. v42

ISSN: 0923-7534; 1569-8041

Online Full Text: dx.doi.org/ (Open Access)
Gröbner, Susanne N.; Worst, Barbara C.; Weischenfeldt, Joachim; Buchhalter, Ivo; Kleinheinz, Kortine; Rudneva, Vasilisa A.; Johann, Pascal D.; Balasubramanian, Gnana Prakash; Segura-Wang, Maia; Brabetz, Sebastian; Bender, Sebastian; Hutter, Barbara; Sturm, Dominik; Pfaff, Elke; Hübschmann, Daniel; Zipprich, Gideon; Heinold, Michael; Eils, Jürgen; Lawerenz, Christian; Erkek, Serap; Lambo, Sander; Waszak, Sebastian; Blattmann, Claudia; Borkhardt, Arndt; Kuhlen, Michaela; Eggert, Angelika; Fulda, Simone; Gessler, Manfred; Wegert, Jenny; Kappler, Roland; Baumhoer, Daniel; Burdach, Stefan; Kirschner-Schwabe, Renate; Kontny, Udo; Kulozik, Andreas E.; Lohmann, Dietmar; Hettmer, Simone; Eckert, Cornelia; Bielack, Stefan; Nathrath, Michaela; Niemeyer, Charlotte; Richter, Günther H.; Schulte, Johannes; Siebert, Reiner; Westermann, Frank; Molenaar, Jan J.; Vassal, Gilles; Witt, Hendrik; Zapatka, Marc; Burkhardt, Birgit; Kratz, Christian P.; Witt, Olaf; Tilburg, Cornelis M. Van; Kramm, Christof M.; Fleischhack, Gudrun; Dirksen, Uta; Rutkowski, Stefan; Frühwald, Michael; Hoff, Katja Von; Wolf, Stephan; Klingebiel, Thomas; Koscielniak, Ewa; Landgraf, Pablo; Koster, Jan; Resnick, Adam C.; Zhang, Jinghui; Liu, Yanling; Zhou, Xin; Waanders, Angela J.; Zwijnenburg, Danny A.; Raman, Pichai; Brors, Benedikt; Weber, Ursula D.; Northcott, Paul A.; Pajtler, Kristian; Kool, Marcel; Piro, Rosario M.; Korbel, Jan O.; Schlesner, Matthias; Eils, Roland; Jones, David T. W.; Lichter, Peter; Chavez, Lukas; Pfister, Stefan M.

The landscape of genomic alterations across childhood cancers

In: Nature Vol. 555 (2018) Nr. 7696, pp. 321 - 327

ISSN: 0028-0836; 1476-4687

Online Full Text: dx.doi.org/ (Open Access)
Costanzo, Margaret C.; Kim, Dohoon; Creegan, Matthew; Lal, Kerri G.; Ake, Julie A.; Currier, Jeffrey R.; Streeck, Hendrik; Robb, Merlin L.; Michael, Nelson L.; Bolton, Diane L.; Steers, Nicholas J.; Eller, Michael A.

Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination

In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 1212

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Hellerschmied-Jelinek, Doris; Roessler, Max; Lehner, Anita; Gazda, Linn; Stejskal, Karel; Imre, Richard; Mechtler, Karl; Dammermann, Alexander; Clausen, Tim

UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins

In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 484

ISSN: 2041-1723

Online Full Text: dx.doi.org/ (Open Access)
Weith, Matthias; Seiler, Jonas; van den Boom, Johannes; Kracht, Matthias; Hülsmann, Julia; Primorac, Ivana; Del Pino Garcia, Javier; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Bollen, Mathieu; Meyer, Hemmo

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation

In: Molecular Cell Vol. 72 (2018) Nr. 4, pp. 766 - 777

ISSN: 1097-2765; 1097-4164

Online Full Text: dx.doi.org/ (Open Access)
Long, Georgina V.; Hauschild, Axel; Santinami, Mario; Atkinson, Victoria G.; Mandala, Mario; Chiarion-Sileni, Vanna; Larkin, James M. G.; Robert, Caroline; Schadendorf, Dirk; Dasgupta, Kohinoor; Shilkrut, Mark; Garrett, James; Brase, Jan C.; Kefford, Rick F.; Kirkwood, John M.; Dummer, Reinhard G.

Updated relapse-free survival (RFS) and biomarker analysis in the COMBI-AD trial of adjuvant dabrafenib + trametinib (D + T) in patients (pts) with resected BRAF V600-mutant stage III melanoma

In: Annals of Oncology: official journal of the European Society for Medical Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii734 - viii735

ISSN: 0923-7534; 1569-8041

Online Full Text: dx.doi.org/ (Open Access)
Schadendorf, Dirk; et.al.

Updated relapse-free survival (RFS) and biomarker analysis in the COMBI-AD trial of adjuvant dabrafenib plus trametinib (D plus T) in patients (pts) with resected BRAF V600-mutant stage III melanoma

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8,

ISSN: 1569-8041; 0923-7534
van den Boom, Johannes; Meyer, Hemmo

VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling

In: Molecular Cell Vol. 69 (2018) Nr. 2, pp. 182 - 194

ISSN: 1097-4164; 1097-2765

Online Full Text: dx.doi.org/ (Open Access)
Lehmann, Nils; Erbel, Raimund; Mahabadi, Amir Abbas; Rauwolf, Michael; Möhlenkamp, Stefan; Moebus, Susanne; Kälsch, Hagen; Budde, Thomas; Schmermund, Axel; Stang, Andreas; Führer-Sakel, Dagmar; Weimar, Christian; Roggenbuck, Ulla; Dragano, Nico; Jöckel, Karl-Heinz

Value of Progression of Coronary Artery Calcification for Risk Prediction of Coronary and Cardiovascular Events : Result of the HNR Study (Heinz Nixdorf Recall)

In: Circulation Vol. 137 (2018) Nr. 7, pp. 665 - 679

ISSN: 1524-4539; 0009-7322

Online Full Text: dx.doi.org/ (Open Access)

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SARS-CoV-2 UV light inactivates corona viruses

DFG Research Grant for Virkramjeet Singh Feedback loops between gut microbes and immune cells may impact outcome after stroke

Erkenntnisse für Test und Impfstoffe Neue Details der Immunantwort bei Covid-19

Deutsch-chinesische Forschung Schwere COVID-19-Verläufe früh erkennen

Schilddrüse beeinflusst Hirnleistung stärker als gedacht Gut fürs Gedächtnis

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Welcome to ZMB

Welcome to ZMB

Connecting

Faculties

Research Groups

Scientists

News & Events

Coronavirus: Current Information(University of Duisburg-Essen)

21.12.2020 Tumor researcher honored

13.10.2020 PD Dr. Adalbert Krawczyk awarded

New Heisenberg Professorship Interlocked molecules as catalysts

Press Releases 2020/2021

ZMB Research Programs

Oncology

Immunology, Infectious Diseases and Transplantation

Molecular and Chemical Cell Biology

Journal articles

Journal articles

Journal articles

Journal articles

Coronavirus: Current Information
(University of Duisburg-Essen)