The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific centre of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.
[28.03.2019] Die Kunst des Faltens („Origami“) gibt es auch in der Natur: die langen DNA-Einzelstränge werden nicht nur in der Biotechnologie mehrdimensional gefaltet – die Molekülketten mit den Erbinformationen können sich sogar selbst falten. Was dahinter steckt, hat die Chemikerin Dr. Barbara Saccà von der UDE erforscht und nun in der Fachzeitschrift Nature Communications veröffentlicht.
[28.01.2019] Das Merkelzell-Karzinom ist ein seltener, aber sehr aggressiver Hautkrebs, der durch ein Virus oder durch UV-Licht ausgelöst wird. Einen Biomarker, mit dem der Therapieerfolg und eventuelle Rückfälle ohne Gewebeentnahme überwacht werden können, haben nun Wissenschaftler des Deutschen Krebskonsortiums (DKTK) an der Medizinischen Fakultät der Universität Duisburg-Essen (UDE) und dem Universitätsklinikum Essen entdeckt.
[23.01.2019] Krankheiten beginnen im Darm – dass wusste schon Hippokrates. Doch wie beeinflussen Nanopartikel in unseren Lebensmitteln die Magen- und Darmflora? Professorin Dr. Shirley Knauer vom Zentrum für Medizinische Biotechnologie (ZMB) der Universität Duisburg-Essen (UDE) stellte mit ihrem Team den Gang der Nanoteilchen im Darm nach.
[16.01.2019] A previously unknown network of fine capillaries directly connecting the bone marrow with the circulation of the periosteum has been discovered by a team of scientists led by Prof. Matthias Gunzer and Dr. Anja Hasenberg from the Institute for Experimental Immunology and Imaging at the University Hospital of the University Duisburg-Essen (UDE) in Germany.
The group was further supported by research institutes in Erlangen, Jena, Berlin, Dresden and Berne (Switzerland). Their results have now been published in the prestigious international journal “Nature Metabolism”.
Toffalori C, et al. Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation. Nat Med. 2019 Apr;25(4):603-611.
Wang K, Sybers D, Maklad HR, Lemmens L, Lewyllie C, Zhou X, Schult F, Bräsen
C, Siebers B, Valegård K, Lindås AC, Peeters E. A TetR-family transcription
factor regulates fatty acid metabolism in the archaeal model organism Sulfolobus
acidocaldarius. Nat Commun. 2019 Apr 4;10(1):1542.
López C, et al. Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma. Nat Commun. 2019 Mar 29;10(1):1459.
Schadendorf D, et al. Patient-reported outcomes in patients
with resected, high-risk melanoma with BRAF(V600E) or BRAF(V600K) mutations
treated with adjuvant dabrafenib plus trametinib (COMBI-AD): a randomised,
placebo-controlled, phase 3 trial. Lancet Oncol. 2019 Mar 27, [Epub ahead of print].
Kosinski R, Mukhortava A, Pfeifer W, Candelli A, Rauch P, Saccà B. Sites of
high local frustration in DNA origami. Nat Commun. 2019 Mar 5;10(1):1061.
Lang PA, Lang KS. Stand by me(mory): Chronic infection diminishes memory pool via IL-6/STAT1. J Exp Med. 2019 Feb 19. pii: jem.20190066. [Epub ahead of print].
Karimzadeh H, Kiraithe MM, Oberhardt V, Alizei ES, Bockmann J, Zur Wiesch JS, Budeus B, Hoffmann D, Wedemeyer H, Cornberg M, Krawczyk A, Rashidi-Alavijeh J, Rodríguez-Frías F, Casillas R, Buti M, Smedile A, Alavian SM, Heinold A, Emmerich F, Panning M, Gostick E, Price DA, Timm J, Hofmann M, Raziorrouh B, Thimme R, Protzer U, Roggendorf M, Neumann-Haefelin C. Mutations in Hepatitis D Virus Allow it to Escape Detection by CD8+ T Cells and Evolve at the Population Level. Gastroenterology. 2019 Feb 12. pii: S0016-5085(19)30366-X. [Epub ahead of print].
Schadendorf D, Livingstone E, Zimmer L. Treatment in metastatic melanoma - Time to re-think. Ann Oncol. 2019 Feb 15. pii: mdz050. [Epub ahead of print]
Wiesweg M, Mairinger F, Reis H, Goetz M, Walter RFH, Hager T, Metzenmacher M, Eberhardt WEE, McCutcheon A, Köster J, Stuschke M, Aigner C, Darwiche K, Schmid KW, Rahmann S, Schuler M. Machine learning-based predictors for immune checkpoint inhibitor therapy of non-small cell lung cancer. Ann Oncol. 2019 Feb 11. [Epub ahead of print].
Kurtz DM, Scherer F, Jin MC, Soo J, Craig AFM, Esfahani MS, Chabon JJ, Stehr H, Liu CL, Tibshirani R, Maeda LS, Gupta NK, Khodadoust MS, Advani RH, Newman AM, Dührsen U, Hüttmann A, Meignan M, Casasnovas O, Westin JR, Roschewski M, Wilson WH, Gaidano G, Rossi D, Diehn M, Alizadeh AA. Reply to J. Wang et al. J Clin Oncol. 2019 Feb 12:JCO1801907. [Epub ahead of print].
Niemeyer J, Mentrup T, Heidasch R, Müller SA, Biswas U, Meyer R, Papadopoulou AA, Dederer V, Haug-Kröper M, Adamski V, Lüllmann-Rauch R, Bergmann M, MayerhoferA, Saftig P, Wennemuth G, Jessberger R, Fluhrer R, Lichtenthaler SF, Lemberg MK, Schröder B. The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban. EMBO Rep. 2019 Feb 7. pii: e46449. [Epub ahead of print].
Dmitrieva-Posocco O, Dzutsev A, Posocco DF, Hou V, Yuan W, Thovarai V, Mufazalov IA, Gunzer M, Shilovskiy IP, Khaitov MR, Trinchieri G, Waisman A, Grivennikov SI. Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer. Immunity. 2019 Jan 15;50(1):166-180.e7.
Mai EK, Hielscher T, Bertsch U, Schlenzka J, Salwender HJ, Munder M, Gerecke C, Dührsen U, Brossart P, Neben K, Hillengass J, Raab MS, Merz M, Baertsch MA, Jauch A, Hose D, Martin H, Lindemann HW, Blau IW, Scheid C, Weisel KC, Goldschmidt H; German-speaking Myeloma Multicenter Group (GMMG). Bortezomib-based induction therapy with high or low-dose dexamethasone in newly diagnosed, transplant-eligible multiple myeloma. Leukemia volume 33, pages258–261 (2019).
Grüneboom A, Hawwari I, Weidner D, Culemann S, Müller S, Henneberg S, Brenzel A, Merz S, Bornemann L, Zec K, Wuelling M, Kling L, Hasenberg M, Voortmann S, Lang, Baum W, Ohs A, Kraff O, Quick HH, Jäger M, Landgraeber S, Dudda M, Danuser R, Stein JV, Rohde M, Gelse K, Garbe AI, Adamczyk A, Westendorf AM, Hoffmann D, Christiansen S, Engel DR, Vortkamp A, Krönke G, Herrmann M, Kamradt T, Schett G, Hasenberg A, Gunzer M. A network of trans-cortical capillaries as mainstay for blood circulation in long bones. Nature Metabolism volume 1, pages236–250 (2019).
2018
Grob JJ, Garbe C, Ascierto P, Larkin J, Dummer R, Schadendorf D. Adjuvant melanoma therapy with new drugs: should physicians continue to focus on metastatic disease or use it earlier in primary melanoma? Lancet Oncol. 2018 Dec;19(12):e720-e725. Review.
Siemer S, Westmeier D, Vallet C, Becker S, Voskuhl J, Ding GB, Thines E, Stauber RH, Knauer SK. Resistance to Nano-Based Antifungals Is Mediated by Biomolecule Coronas.
ACS Appl Mater Interfaces. 2018 Dec 18.[Epub ahead of print].
Juric D, Janku F, Rodón J, Burris HA, Mayer IA, Schuler M, Seggewiss-Bernhardt R, Gil-Martin M, Middleton MR, Baselga J, Bootle D, Demanse D, Blumenstein L, Schumacher K, Huang A, Quadt C, Rugo HS. Alpelisib Plus Fulvestrant in PIK3CA-Altered and PIK3CA-Wild-Type Estrogen Receptor-Positive Advanced Breast Cancer: A Phase 1b Clinical Trial. JAMA Oncol. 2018 Dec 13:e184475. [Epub ahead of print].
Ackermann S, Cartolano M, Hero B, Welte A, Kahlert Y, Roderwieser A,
Bartenhagen C, Walter E, Gecht J, Kerschke L, Volland R, Menon R, Heuckmann JM,
Gartlgruber M, Hartlieb S, Henrich KO, Okonechnikov K, Altmüller J, Nürnberg P,
Lefever S, de Wilde B, Sand F, Ikram F, Rosswog C, Fischer J, Theissen J, Hertwig
F, Singhi AD, Simon T, Vogel W, Perner S, Krug B, Schmidt M, Rahmann S, Achter V,
Lang U, Vokuhl C, Ortmann M, Büttner R, Eggert A, Speleman F, O'Sullivan RJ,
Thomas RK, Berthold F, Vandesompele J, Schramm A, Westermann F, Schulte JH,
Peifer M, Fischer M. A mechanistic classification of clinical phenotypes in
neuroblastoma. Science. 2018 Dec 7;362(6419):1165-1170.
Siemer S, Hahlbrock A, Vallet C, McClements DJ, Balszuweit J, Voskuhl J, Docter D, Wessler S, Knauer SK, Westmeier D, Stauber RH. Nanosized food additives impact beneficial and pathogenic bacteria in the human gut: a simulated gastrointestinal study. npj science of food, 22 (2018) Dec 4.
Siemer S, Westmeier D, Barz M, Eckrich J, Wünsch D, Seckert C, Thyssen C, Schilling O, Hasenberg M, Pang C, Docter D, Knauer SK, Stauber RH, Strieth S. Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics. Biomaterials. 2018 Nov 21;192:551-559. [Epub ahead of print].
Urbonas V, Schadendorf D, Zimmer L, Danson S, Marshall E, Corrie P, Wheater M, Plummer E, Mauch C, Scudder C, Goff M, Love SB, Mohammed SB, Middleton MR. Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF Melanoma (PACMEL): a multicentre, open-label, randomised, controlled phase II trial. Ann Oncol. 2018 Nov 14. [Epub ahead of print].
Jerby-Arnon L, et al. A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. Cell. 2018 Nov 1;175(4):984-997.e24.
Ascierto PA, Long GV, Robert C, Brady B, Dutriaux C, Di Giacomo AM, Mortier L, Hassel JC, Rutkowski P, McNeil C, Kalinka-Warzocha E, Savage KJ, Hernberg MM, Lebbé C, Charles J, Mihalcioiu C, Chiarion-Sileni V, Mauch C, Cognetti F, Ny L, Arance A, Svane IM, Schadendorf D, Gogas H, Saci A, Jiang J, Rizzo J, Atkinson V. Survival Outcomes in Patients With Previously Untreated BRAF Wild-Type Advanced Melanoma Treated With Nivolumab Therapy: Three-Year Follow-up of a Randomized Phase 3 Trial. JAMA Oncol. 2018 Oct 25. [Epub ahead of print].
Hodi FS, Chiarion-Sileni V, Gonzalez R, Grob JJ, Rutkowski P, Cowey CL, Lao CD, Schadendorf D, Wagstaff J, Dummer R, Ferrucci PF, Smylie M, Hill A, Hogg D, Marquez-Rodas I, Jiang J, Rizzo J, Larkin J, Wolchok JD. Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067): 4-year outcomes of a multicentre, randomised, phase 3 trial. Lancet Oncol. 2018 Nov;19(11):1480-1492. Epub 2018 Oct 22. Erratum in: Lancet Oncol. 2018 Dec;19(12):e668. Lancet Oncol. 2018 Nov;19(11):e581.
Urbonas V, Schadendorf D, Zimmer L, Danson S, Marshall E, Corrie P, Wheater M, Plummer E, Mauch C, Scudder C, Goff M, Love SB, Mohammed SB, Middleton MR. Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF Melanoma (PACMEL): a multicentre, open-label, randomised, controlled phase II trial. Ann Oncol. 2018 Nov 14. [Epub ahead of print].
Casanova-Acebes M, Nicolás-Ávila JA, Li JL, García-Silva S, Balachander A,
Rubio-Ponce A, Weiss LA, Adrover JM, Burrows K, A-González N, Ballesteros I, Devi
S, Quintana JA, Crainiciuc G, Leiva M, Gunzer M, Weber C, Nagasawa T, Soehnlein
O, Merad M, Mortha A, Ng LG, Peinado H, Hidalgo A. Neutrophils instruct
homeostatic and pathological states in naive tissues. J Exp Med. 2018 Nov 5;215(11):2778-2795.
Totzeck M, Mahabadi AA, Schlosser T, Rassaf T. Weightlifting unmasks high-risk coronary anomaly. Eur Heart J. 2018 Nov 13. [Epub ahead of print].
Jockenhöfer F, Schimming TT, Schaller J, Moege J, Livingstone E, Salva KA, Zimmer L, Schadendorf D, Rösch A. Sebaceous tumours: more than skin deep. Gut. 2018 Nov;67(11):1957.
Jerby-Arnon L, et al. A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. Cell. 2018 Nov 1;175(4):984-997.e24.
Weith M, Seiler J, van den Boom J, Kracht M, Hülsmann J, Primorac I, del Pino Garcia J, Kaschani F, Kaiser M, Musacchio A, Bollen M, Meyer H. Ubiquitin-independent disassembly by a p97 AAA-ATPase complex drives PP1 holoenzyme formation. Mol Cell, 2018, doi: 10.1016/j.molcel.2018.09.020.
Ascierto PA, Long GV, Robert C, Brady B, Dutriaux C, Di Giacomo AM, Mortier L, Hassel JC, Rutkowski P, McNeil C, Kalinka-Warzocha E, Savage KJ, Hernberg MM, Lebbé C, Charles J, Mihalcioiu C, Chiarion-Sileni V, Mauch C, Cognetti F, Ny L, Arance A, Svane IM, Schadendorf D, Gogas H, Saci A, Jiang J, Rizzo J, Atkinson V. Survival Outcomes in Patients With Previously Untreated BRAF Wild-Type Advanced Melanoma Treated With Nivolumab Therapy: Three-Year Follow-up of a Randomized Phase 3 Trial. JAMA Oncol. 2018 Oct 25. [Epub ahead of print].
Hauschild A, Dummer R, Schadendorf D, Santinami M, Atkinson V, Mandalà M, Chiarion-Sileni V, Larkin J, Nyakas M, Dutriaux C, Haydon A, Robert C, Mortier L, Schachter J, Lesimple T, Plummer R, Dasgupta K, Haas T, Shilkrut M, Gasal E, Kefford R, Kirkwood JM, Long GV. Longer Follow-Up Confirms Relapse-Free Survival Benefit With Adjuvant Dabrafenib Plus Trametinib in Patients With Resected BRAF V600-Mutant Stage III Melanoma. J Clin Oncol. 2018 Oct 22:JCO1801219.
Hodi FS, Chiarion-Sileni V, Gonzalez R, Grob JJ, Rutkowski P, Cowey CL, Lao CD, Schadendorf D, Wagstaff J, Dummer R, Ferrucci PF, Smylie M, Hill A, Hogg D, Marquez-Rodas I, Jiang J, Rizzo J, Larkin J, Wolchok JD. Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067): 4-year outcomes of a multicentre, randomised, phase 3 trial. Lancet Oncol. 2018 Oct 18. pii: S1470-2045(18)30700-9.
Sokolova V, Loza K, Knuschke T, Heinen-Weiler J, Jastrow H, Hasenberg M, Buer
J, Westendorf AM, Gunzer M, Epple M. A systematic electron microscopic study on
the uptake of barium sulphate nano-, submicro-, microparticles by bone
marrow-derived phagocytosing cells. Acta Biomater . 2018 Oct 15;80:352-363.
Knier B, Hiltensperger M, Sie C, Aly L, Lepennetier G, Engleitner T, Garg G,
Muschaweckh A, Mitsdörffer M, Koedel U, Höchst B, Knolle P, Gunzer M, Hemmer B,
Rad R, Merkler D, Korn T. Myeloid-derived suppressor cells control B cell
accumulation in the central nervous system during autoimmunity. Nat Immunol. 2018
Oct 29.[Epub ahead of print].
Wagener R, López C, Kleinheinz K, Bausinger J, Aukema SM, Nagel I, Toprak UH, Seufert J, Altmüller J, Thiele H, Schneider C, Kolarova J, Park J, Hübschmann D, Murga Penas EM, Drexler HG, Attarbaschi A, Hovland R, Kjeldsen E, Kneba M, Kontny U, de Leval L, Nürnberg P, Oschlies I, Oscier D, Schlegelberger B, Stilgenbauer S, Wössmann W, Schlesner M, Burkhardt B, Klapper W, Jaffe ES, Küppers R, Siebert R. IG-MYC-positive neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas. Blood. 2018 Oct 3. pii: blood-2018-03-842088.
Lang S, Bruderek K, Kaspar C, Höing B, Kanaan O, Dominas N, Hussain T, Droege
F, Eyth C, Hadaschik B, Brandau S. Clinical Relevance and Suppressive Capacity of
Human Myeloid-Derived Suppressor Cell Subsets. Clin Cancer Res. 2018 Oct 1;24(19):4834-4844.
Mangolini M, Götte F, Moore A, Ammon T, Oelsner M, Lutzny-Geier G,
Klein-Hitpass L, Williamson JC, Lehner PJ, Dürig J, Möllmann M, Rásó-Barnett L, Hughes K, Santoro A, Méndez-Ferrer S, Oostendorp RAJ, Zimber-Strobl U, Peschel C,
Hodson DJ, Schmidt-Supprian M, Ringshausen I. Notch2 controls non-autonomous
Wnt-signalling in chronic lymphocytic leukaemia. Nat Commun. 2018 Sep
21;9(1):3839.
Pesenti ME, Prumbaum D, Auckland P, Smith CM, Faesen AC, Petrovic A, Erent M,
Maffini S, Pentakota S, Weir JR, Lin YC, Raunser S, McAinsh AD, Musacchio A.
Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule
Binding by CENP-OPQUR and NDC80. Mol Cell. 2018 Sep 20;71(6):923-939.e10.
Dührsen U, Müller S, Rekowski J, Hüttmann A. Reply to H.J.A Adams et al and C.Gisselbrecht. J Clin Oncol. 2018 Sep 17:JCO1800898.
Schadendorf D, Akkooi ACJ, Berking C, Griewank KG, Gutzmer R, Hauschild A, Stang A, Roesch A, Ugurel S. Lancet Seminar – Melanoma. The Lancet, 2018 Sep 15;392(10151):971-984. Review.
Dummer R, Ascierto PA, Gogas HJ, Arance A, Mandala M, Liszkay G, Garbe C,
Schadendorf D, Krajsova I, Gutzmer R, Chiarion Sileni V, Dutriaux C, de Groot JWB, Yamazaki N, Loquai C, Moutouh-de Parseval LA, Pickard MD, Sandor V, Robert
C, Flaherty KT. Overall survival in patients with BRAF-mutant melanoma receiving
encorafenib plus binimetinib versus vemurafenib or encorafenib (COLUMBUS): a
multicentre, open-label, randomised, phase 3 trial. Lancet Oncol. 2018 Sep 12. pii: S1470-2045(18)30497-2.
Mahabadi AA, Rassaf T. Imaging of coronary inflammation for cardiovascular
risk prediction. Lancet. 2018 Aug 24. pii: S0140-6736(18)31716-1. [Epub ahead of print].
Miao et al. Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors. Nat Genet. 2018
Sep;50(9):1271-1281.
Kurtz DM, et al. Circulating Tumor DNA
Measurements As Early Outcome Predictors in Diffuse Large B-Cell Lymphoma. J Clin
Oncol. 2018 Aug 20:JCO2018785246.
Shen B, Tatchen J, Sanchez-Garcia E, Bettinger HF. Evolution of the Optical
Gap in the Acene Series: Undecacene. Angew Chem Int Ed Engl. 2018 Aug
13;57(33):10506-10509.
Horsthemke B. A critical view on transgenerational epigenetic inheritance in humans. Nat Commun. 2018 Jul 30;9(1):2973.
Horst AK, Wegscheid C, Schaefers C, Schiller B, Neumann K, Lunemann S,
Langeneckert AE, Oldhafer KJ, Weiler-Normann C, Lang KS, Singer BB, Altfeld M, Diehl L, Tiegs G. Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice.Hepatology. 2018 Jul;68(1):200-214.
Westmeier D, Solouk-Saran D, Vallet C, Siemer S, Docter D, Götz H, Männ L,
Hasenberg A, Hahlbrock A, Erler K, Reinhardt C, Schilling O, Becker S, Gunzer M,
Hasenberg M, Knauer SK, Stauber RH. Nanoparticle decoration impacts airborne
fungal pathobiology. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7087-7092.
Khairnar V, Duhan V, Patil AM, Zhou F, Bhat H, Thoens C, Sharma P, Adomati T,
Friendrich SK, Bezgovsek J, Dreesen JD, Wennemuth G, Westendorf AM, Zelinskyy G,
Dittmer U, Hardt C, Timm J, Göthert JR, Lang PA, Singer BB, Lang KS. CEACAM1 promotes CD8(+) T cell responses and improves control of a chronic viral
infection. Nat Commun. 2018 Jul 2;9(1):2561.
Trusch F, Loebach L, Wawra S, Durward E, Wuensch A, Iberahim NA, de Bruijn I,
MacKenzie K, Willems A, Toloczko A, Diéguez-Uribeondo J, Rasmussen T, Schrader T,
Bayer P, Secombes CJ, van West P. Cell entry of a host-targeting protein of
oomycetes requires gp96. Nat Commun. 2018 Jun 14;9(1):2347.
Weske S, Vaidya M, Reese A, von Wnuck Lipinski K, Keul P, Bayer JK, Fischer
JW, Flögel U, Nelsen J, Epple M, Scatena M, Schwedhelm E, Dörr M, Völzke H,
Moritz E, Hannemann A, Rauch BH, Gräler MH, Heusch G, Levkau B. Targeting
sphingosine-1-phosphate lyase as an anabolic therapy for bone loss. Nat Med. 2018 May;24(5):667-678.
Dummer R, Ascierto PA, Gogas HJ, Arance A, Mandala M, Liszkay G, Garbe C,
Schadendorf D, Krajsova I, Gutzmer R, Chiarion-Sileni V, Dutriaux C, de Groot JWB, Yamazaki N, Loquai C, Moutouh-de Parseval LA, Pickard MD, Sandor V, Robert C, Flaherty KT. Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS): a multicentre, open-label,
randomised phase 3 trial. Lancet Oncol. 2018 May;19(5):603-615.
Ter Veer E, et al. Consensus statement on mandatory measurements in
pancreatic cancer trials (COMM-PACT) for systemic treatment of unresectable
disease. Lancet Oncol. 2018 Mar;19(3):e151-e160. Review.
Ziemann S, van der Linde K, Lahrmann U, Acar B, Kaschani F, Colby T, Kaiser M,
Ding Y, Schmelz E, Huffaker A, Holton N, Zipfel C, Doehlemann G. An apoplastic
peptide activates salicylic acid signalling in maize. Nat Plants. 2018
Mar;4(3):172-180.
Maio M, Lewis K, Demidov L, Mandalà M, Bondarenko I, Ascierto PA, Herbert C,
Mackiewicz A, Rutkowski P, Guminski A, Goodman GR, Simmons B, Ye C, Yan Y,
Schadendorf D; BRIM8 Investigators. Adjuvant vemurafenib in resected, BRAF(V600)
mutation-positive melanoma (BRIM8): a randomised, double-blind,
placebo-controlled, multicentre, phase 3 trial. Lancet Oncol. 2018 Apr;19(4):510-520.
McQuade JL, et al. Association of body-mass index and outcomes in patients with metastatic melanoma
treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective,
multicohort analysis. Lancet Oncol. 2018 Mar;19(3):310-322.
Tucci FA, Kitanovski S, Johansson P, Klein-Hitpass L, Kahraman A, Dürig J, Hoffmann D, Küppers R. Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus-infected individuals. Blood. 2018 Feb 1;131(5):546-557.
Juric D, Rodon J, Tabernero J, Janku F, Burris HA, Schellens JHM, Middleton
MR, Berlin J, Schuler M, Gil-Martin M, Rugo HS, Seggewiss-Bernhardt R, Huang A,
Bootle D, Demanse D, Blumenstein L, Coughlin C, Quadt C, Baselga J.
Phosphatidylinositol 3-Kinase α-Selective Inhibition With Alpelisib (BYL719) in
PIK3CA-Altered Solid Tumors: Results From the First-in-Human Study. J Clin Oncol.
2018 Feb 5:JCO2017727107.
Pöhler R, Krahn JH, van den Boom J, Dobrynin G, Kaschani F, Eggenweiler HM,
Zenke FT, Kaiser M, Meyer H. A Non-Competitive Inhibitor of VCP/p97 and VPS4
Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases. Angew Chem
Int Ed Engl. 2018 Feb 5;57(6):1576-1580.
Ross B, Krapp S, Augustin M, Kierfersauer R, Arciniega M, Geiss-Friedlander R,
Huber R. Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1437-E1445.
Schadendorf D, Jiang J, Kelleher T, Postow MA. Reply to M. Horiguchi et al. J Clin Oncol. 2018 Mar 1;36(7):721.
Tucci FA, Kitanovski S, Johansson P, Klein-Hitpass L, Kahraman A, Dürig J, Hoffmann D, Küppers R. Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus-infected individuals. Blood. 2018 Feb 1;131(5):546-557.
Pöhler R, Krahn JH, van den Boom J, Dobrynin G, Kaschani F, Eggenweiler HM,Zenke FT, Kaiser M, Meyer H. A non-competitive inhibitor of VCP/p97 and VPS4 reveals conserved allosteric circuits in type I and II AAA ATPases. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1576-1580.
van den Boom J, Meyer H. VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. Mol Cell. 2018 Jan 18;69(2):182-194. Review.
Hönes GS, Rakov H, Logan J, Liao XH, Werbenko E, Pollard AS, Præstholm SM, Siersbæk MS, Rijntjes E, Gassen J, Latteyer S, Engels K, Strucksberg KH, Kleinbongard P, Zwanziger D, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Klein-Hitpass L, Köhrle J, Armstrong DL, Grøntved L, Bassett JHD, Williams GR, Refetoff S, Führer D, Moeller LC. Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11323-E11332.
von Wnuck Lipinski K, Weske S, Keul P, Peters S, Baba HA, Heusch G, Gräler MH, Levkau B. Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis. Blood. 2017 Dec 21;130(25):2786-2798.
Sokolova V, Shi Z, Huang S, Du Y, Kopp M, Frede A, Knuschke T, Buer J, Yang D,
Wu J, Westendorf AM, Epple M. Delivery of the TLR ligand poly(I:C) to liver cells
in vitro and in vivo by calcium phosphate nanoparticles leads to a pronounced
immunostimulation. Acta Biomater. 2017 Dec;64:401-410.
Graessl M, Koch J, Calderon A, Kamps D, Banerjee S, Mazel T, Schulze N,
Jungkurth JK, Patwardhan R, Solouk D, Hampe N, Hoffmann B, Dehmelt L, Nalbant P.
An excitable Rho GTPase signaling network generates dynamic subcellular
contraction patterns. J Cell Biol. 2017 Dec 4;216(12):4271-4285.
Romagnani A, Vettore V, Rezzonico-Jost T, Hampe S, Rottoli E, Nadolni W, Perotti M, Meier MA, Hermanns C, Geiger S, Wennemuth G, Recordati C, Matsushita M, Muehlich S, Proietti M, Chubanov V, Gudermann T, Grassi F, Zierler S. TRPM7
kinase activity is essential for T cell colonization and alloreactivity in the gut. Nat Commun. 2017 Dec 4;8(1):1917.
Gunzer M. Escaping the traps of your own hunters. Science. 2017 Dec 1;358(6367):1126-1127.
Schadendorf D et al. Efficacy and Safety Outcomes in Patients With Advanced Melanoma Who Discontinued Treatment With Nivolumab and Ipilimumab
Because of Adverse Events: A Pooled Analysis of Randomized Phase II and III
Trials. J Clin Oncol. 2017 Dec 1;35(34):3807-3814.
Schmitzberger F*, Richter MM, Gordiyenko Y, Robinson CV, Dadlez M, Westermann S. Molecular basis for inner kinetochore configuration through RWD domain–peptide interactions. The EMBO Journal (2017) Dec 1;36(23):3458-3482. * corresponding author
Krzywinska E, Kantari-Mimoun C, Kerdiles Y, Sobecki M, Isagawa T, Gotthardt D, Castells M, Haubold J, Millien C, Viel T, Tavitian B, Takeda N, Fandrey J, Vivier E, Sexl V, Stockmann C. Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis. Nat Commun. 2017 Nov 17;8(1):1597.
Bier D, Mittal S, Bravo-Rodriguez K, Sowislok A, Guillory X, Briels J, Heid C,
Bartel M, Wettig B, Brunsveld L, Sanchez-Garcia E, Schrader T, Ottmann C. The
Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J Am
Chem Soc. 2017 Nov 15;139(45):16256-16263
Schmuck C, Jiang H, Hu XY, Schlesiger S, Li M, Zellermann E, Knauer S. Morphology Dependent Cell Imaging by a Self-assembled Diacetylene Peptide
Amphiphile. Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14526-14530.
Hogeweg A, Sowislok A, Schrader T, Beuck C. An NMR Method To Pinpoint Supramolecular Ligand Binding to Basic Residues on Proteins. Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14758-14762.
Long GV, et al. Adjuvant Dabrafenib plus Trametinib in Stage
III BRAF-Mutated Melanoma. N Engl J Med. 2017 Nov 9;377(19):1813-1823.
van der Vaart B, Fischböck J, Mieck C, Pichler P, Mechtler K, Medema RH,
Westermann S. TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2. J Cell Biol. 2017 Nov 6;216(11):3471-3484.
Long GV, Weber JS, Larkin J, Atkinson V, Grob JJ, Schadendorf D, Dummer R, Robert C, Márquez-Rodas I, McNeil C, Schmidt H, Briscoe K, Baurain JF, Hodi FS, Wolchok JD. Nivolumab for Patients With Advanced Melanoma Treated Beyond Progression: Analysis of 2 Phase 3 Clinical Trials. JAMA Oncol. 2017 Nov 1;3(11):1511-1519.
Herold S, Sockel K, Sayehli C, Herbst R, Dührsen U, Oelschlägel U, Böttner A,Hindahl H, Kullmer J, Helas S, Sauer M, Mohr B, Mies A, Bornhäuser M, Ehninger G, Röllig C, Thiede C, Platzbecker U. Evolution of NPM1-negative therapy-relatedmyelodysplastic syndromes following curative treatment of NPM1-mutant AML. Leukemia. 2017 Oct;31(10):2247-2251.
Wang J, Hossain M, Thanabalasuriar A, Gunzer M, Meininger C, Kubes P.
Visualizing the function and fate of neutrophils in sterile injury and repair. Science. 2017 Oct 6;358(6359):111-116.
Wolchok JD, et al. Overall Survival with Combined
Nivolumab and Ipilimumab in Advanced Melanoma. N Engl J Med. 2017 Oct 5;377(14):1345-1356.
Jacquelot N, et.al.
Predictors of responses to immune checkpoint blockade in advanced melanoma. Nat
Commun. 2017 Sep 19;8(1):592.
Item F, Wueest S, Lemos V, Stein S, Lucchini FC, Denzler R, Fisser MC, Challa
TD, Pirinen E, Kim Y, Hemmi S, Gulbins E, Gross A, O'Reilly LA, Stoffel M, Auwerx J, Konrad D. Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function. Nat Commun. 2017 Sep 7;8(1):480.
Ahci M, Toffalori C, Bouwmans E, Crivello P, Brambati C, Pultrone C, Stempelmann K, Bost D, Mazzi B, Beelen DW, Ciceri F, Mulder W, Fleischhauer K, Vago L. A new tool for rapid and reliable diagnosis of HLA loss relapses after HSCT. Blood. 2017 Sep 7;130(10):1270-1273.
Tsegaw YA, Kadam PE, Tötsch N, Sanchez-Garcia E, Sander W. Is Magnetic Bistability of Carbenes a General Phenomenon? Isolation of Simple Aryl(trifluoromethyl)carbenes in Both Their Singlet and Triplet States. J Am Chem Soc. 2017 Sep 6;139(35):12310-12316.
Duncan L, Yilmaz Z, Gaspar H, Walters R, Goldstein J, Anttila V,
Bulik-Sullivan B, Ripke S; Eating Disorders Working Group of the Psychiatric
Genomics Consortium, Thornton L, Hinney A, Daly M, Sullivan PF, Zeggini E, Breen G, Bulik CM. Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa. Am J Psychiatry. Sep 1;174(9):850-858.
Fleischhauer K, Shaw BE. HLA-DP in unrelated hematopoietic cell transplantation revisited: challenges and opportunities. Blood. 2017 Aug 31;130(9):1089-1096.
Zocchi D, Wennemuth G, Oka Y. The cellular mechanism for water detection in
the mammalian taste system. Nat Neurosci. 2017 Jul;20(7):927-933.
Köcher S, Rey J, Bongard J, Tiaden AN, Meltzer M, Richards PJ, Ehrmann M, Kaiser M. Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease Inhibitors. Angew Chem Int Ed Engl. 2017 Jul 10;56(29):8555-8558.
van der Meer SB, Knuschke T, Frede A, Schulze N, Westendorf AM, Epple M. Avidin-conjugated calcium phosphate nanoparticles as a modular targeting system
for the attachment of biotinylated molecules in vitro and in vivo. Acta Biomater.
2017 Jul 15;57:414-425.
Larkin J, Minor D, D'Angelo S, Neyns B, Smylie M, Miller WH Jr, Gutzmer R,Linette G, Chmielowski B, Lao CD, Lorigan P, Grossmann K, Hassel JC, Sznol M,Daud A, Sosman J, Khushalani N, Schadendorf D, Hoeller C, Walker D, Kong G, Horak C, Weber J. Overall Survival in Patients With Advanced Melanoma Who Received Nivolumab Versus Investigator's Choice Chemotherapy in CheckMate 037: A
Randomized, Controlled, Open-Label Phase III Trial. J Clin Oncol. 2017 Jul 3:JCO2016718023.
Lollies A, Hartmann S, Schneider M, Bracht T, Weiß AL, Arnolds J, Klein-Hitpass L, Sitek B, Hansmann ML, Küppers R, Weniger MA. An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma. Leukemia. 2017 Jun 29. [Epub ahead of print]
Jana P, Samanta K, Bäcker S, Zellermann E, Knauer S, Schmuck C. Efficient Gene
Transfection through Inhibition of β-Sheet (Amyloid Fiber) Formation of a Short
Amphiphilic Peptide by Gold Nanoparticles. Angew Chem Int Ed Engl. 2017, 56, 8083.
Sucker A, Zhao F, Pieper N, Heeke C, Maltaner R, Stadtler N, Real B, Bielefeld
N, Howe S, Weide B, Gutzmer R, Utikal J, Loquai C, Gogas H, Klein-Hitpass L,
Zeschnigk M, Westendorf AM, Trilling M, Horn S, Schilling B, Schadendorf D,
Griewank KG, Paschen A. Acquired IFNγ resistance impairs anti-tumor immunity and
gives rise to T-cell-resistant melanoma lesions. Nat Commun. 2017 May 31;8:15440.
Ascierto PA, et al. Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma: a randomised, double-blind, multicentre, phase 3 trial. Lancet Oncol.2017 May;18(5):611-622.
Zweerink S, Kallnik V, Ninck S,Nickel S, Verheyen J, Blum M, Wagner A, Feldmann I, Sickmann A, Albers SV, Bräsen C, Kaschani F, Siebers B & Kaiser M. Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic Archaea. Nat Commun. 2017/05/08/online.
Vöpel T, Bravo-Rodriguez K, Mittal S, Vachharajani S, Gnutt D, Sharma A,
Steinhof A, Fatoba O, Ellrichmann G, Nshanian M, Heid C, Loo JA, Klärner FG,
Schrader T, Bitan G, Wanker EE, Ebbinghaus S, Sanchez-Garcia E. Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01. J Am Chem Soc 2017 Apr 26;139(16):5640-5643.
Klein JC, Moses K, Zelinskyy G, Sody S, Buer J, Lang S, Helfrich I, Dittmer U,
Kirschning CJ, Brandau S. Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth. Nat Commun. 2017 Mar 16;8:14600.
Brandau S, Hartl D. Lost in neutrophil heterogeneity? CD10! Blood. 2017 Mar 9;129(10):1240-1241.
Kalkavan H, Sharma P, Kasper S, Helfrich I, Pandyra AA, Gassa A, Virchow I,
Flatz L, Brandenburg T, Namineni S, Heikenwalder M, Höchst B, Knolle PA, Wollmann
G, von Laer D, Drexler I, Rathbun J, Cannon PM, Scheu S, Bauer J, Chauhan J,
Häussinger D, Willimsky G, Löhning M, Schadendorf D, Brandau S, Schuler M, Lang PA, Lang KS. Spatiotemporally restricted arenavirus replication induces immune
surveillance and type I interferon-dependent tumour regression. Nat Commun. 2017
Mar 1;8:14447.
Heid I, Steiger K, Trajkovic-Arsic M, Settles M, Eßwein MR, Erkan M, Kleeff J,
Jäger C, Friess H, Haller B, Steingötter A, Schmid RM, Schwaiger M, Rummeny EJ,
Esposito I, Siveke JT, Braren RF. Co-clinical Assessment of Tumor Cellularity in
Pancreatic Cancer. Clin Cancer Res. 2017 Mar 15;23(6):1461-1470.
Dréno B, Kunstfeld R, Hauschild A, Fosko S, Zloty D, Labeille B, Grob JJ, Puig
S, Gilberg F, Bergström D, Page DR, Rogers G, Schadendorf D. Two intermittent
vismodegib dosing regimens in patients with multiple basal-cell carcinomas
(MIKIE): a randomised, regimen-controlled, double-blind, phase 2 trial. Lancet
Oncol. 2017 Mar;18(3):404-412.
Sprengel A, Lill P, Stegemann P, Bravo-Rodriguez K, Schöneweiß EC, Merdanovic
M, Gudnason D, Aznauryan M, Gamrad L, Barcikowski S, Sanchez-Garcia E, Birkedal V, Gatsogiannis C, Ehrmann M, Saccà B. Tailored protein encapsulation into a DNA
host using geometrically organized supramolecular interactions. Nat Commun. 2017 Feb 16;8:14472.
Wang-Gillam A, Von Hoff D, Siveke J, Hubner R, Belanger B, Pipas JM, Chen LT.
Nanoliposomal Irinotecan in the Clinical Practice Guideline for Metastatic
Pancreatic Cancer: Applicability to Clinical Situations. J Clin Oncol. 2017 Feb
20;35(6):689-690.
Lindsley RC, Saber W, Mar BG, Redd R, Wang T, Haagenson MD, Grauman PV, Hu ZH,
Spellman SR, Lee SJ, Verneris MR, Hsu K, Fleischhauer K, Cutler C, Antin JH,
Neuberg D, Ebert BL. Prognostic Mutations in Myelodysplastic Syndrome after
Stem-Cell Transplantation. N Engl J Med. 2017 Feb 9;376(6):536-547.
Faesen AC, Thanasoula M, Maffini S, Breit C, Müller F, van Gerwen S, Bange T,
Musacchio A. Basis of catalytic assembly of the mitotic checkpoint complex.
Nature. 2017 23;542(7642):498-502.
Papadopoulos C, Kirchner P, Bug M, Grum D, Koerver L, Schulze N, Poehler R, Dressler A, Fengler S, Arhzaouy K, Lux V, Ehrmann M, Weihl CC, Meyer H. VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. EMBO J. 2017 Jan 17;36(2):135-150.
Nogova L, Sequist LV, Perez Garcia JM, Andre F, Delord JP, Hidalgo M,
Schellens JH, Cassier PA, Camidge DR, Schuler M, Vaishampayan U, Burris H, Tian
GG, Campone M, Wainberg ZA, Lim WT, LoRusso P, Shapiro GI, Parker K, Chen X,
Choudhury S, Ringeisen F, Graus-Porta D, Porter D, Isaacs R, Buettner R, Wolf J.
Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor,
in Patients With Advanced Solid Tumors Harboring Genetic Alterations in
Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation
and Dose-Expansion Study. J Clin Oncol. 2017 Jan 10;35(2):157-165.
Okimoto RA, Breitenbuecher F, Olivas VR, Wu W, Gini B, Hofree M, Asthana S,
Hrustanovic G, Flanagan J, Tulpule A, Blakely CM, Haringsma HJ, Simmons AD, Gowen
K, Suh J, Miller VA, Ali S, Schuler M, Bivona TG. Inactivation of Capicua drives
cancer metastasis. Nat Genet. 2017 Jan;49(1):87-96.
Petrovic A, Keller J, Liu Y, Overlack K, John J, Dimitrova YN, Jenni S, van
Gerwen S, Stege P, Wohlgemuth S, Rombaut P, Herzog F, Harrison SC, Vetter IR,
Musacchio A. Structure of the MIS12 Complex and Molecular Basis of Its
Interaction with CENP-C at Human Kinetochores. Cell. 2016 Nov 3;167(4):1028-1040.e15.
Long GV, Grob JJ, Nathan P, Ribas A, Robert C, Schadendorf D, Lane SR, Mak C,
Legenne P, Flaherty KT, Davies MA. Factors predictive of response, disease
progression, and overall survival after dabrafenib and trametinib combination
treatment: a pooled analysis of individual patient data from randomised trials.
Lancet Oncol. 2016 Nov 15. pii: S1470-2045(16)30578-2.
Jana P, Ehlers M, Zellermann E, Samanta K, Schmuck C. pH-Controlled Formation of a Stable β-Sheet and Amyloid-like Fibers from an Amphiphilic Peptide: The Importance of a Tailor-Made Binding Motif for Secondary Structure Formation. Angew Chem Int Ed Engl 2016 Dec 5;55(49):15287-15291.
Hu Y, Kim JH, He K, Wan Q, Kim J, Flach M, Kirchhausen T, Vortkamp A, Winau F.
Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell
exhaustion. J Exp Med. 2016 Nov 14;213(12):2759-2772.
Merino F, Raunser S. Cryo-EM as a tool for structure-based drug development.
Angew Chem Int Ed Engl. 2016 Nov 10. [Epub ahead of print].
Arumughan A, Roske Y, Barth C, Forero LL, Bravo-Rodriguez K, Redel A, Kostova
S, McShane E, Opitz R, Faelber K, Rau K, Mielke T, Daumke O, Selbach M,
Sanchez-Garcia E, Rocks O, Panáková D, Heinemann U, Wanker EE. Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. Nat Commun. 2016 Oct 20;7:13047.
Javaheri A, Kruse T, Moonens K, Mejías-Luque R, Debraekeleer A, Asche CI,
Tegtmeyer N, Kalali B, Bach NC, Sieber SA, Hill DJ, Königer V, Hauck CR,
Moskalenko R, Haas R, Busch DH, Klaile E, Slevogt H, Schmidt A, Backert S, Remaut
H, Singer BB, Gerhard M. Helicobacter pylori adhesin HopQ engages in a
virulence-enhancing interaction with human CEACAMs. Nat Microbiol. 2016 Oct 17;2:16189.
Molodtsov MI, Mieck C, Dobbelaere J, Dammermann A,
Westermann S*, Vaziri A*. A Force-Induced Directional Switch of a Molecular Motor Enables Parallel Microtubule Bundle Formation. Cell. 2016 Oct 6;167(2):539-552.e14, *co-corresponding authors.
Knorr J, Sokkar P, Schott S, Costa P, Thiel W, Sander W, Sanchez-Garcia E,Nuernberger P. Competitive solvent-molecule interactions govern primary processes of diphenylcarbene in solvent mixtures. Nat Commun. 2016 Oct 6;7:12968.
van den Boom J, Wolf M, Weimann L, Schulze N, Li F, Kaschani F, Riemer A, Zierhut C, Kaiser M, Iliakis G, Funabiki H, Meyer H. VCP/p97 extracts sterically trapped Ku70/80 rings from DNA in double strand break repair. Mol. Cell, 2016, 64: 189–198.
Gatsogiannis C, Merino F, Prumbaum D, Roderer D, Leidreiter F, Meusch D,
Raunser S. Membrane insertion of a Tc toxin in near-atomic detail. Nat Struct Mol Biol. 2016 Oct;23(10):884-890.
Al-Batran SE et al. Histopathological regression after neoadjuvant docetaxel, oxaliplatin,
fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or
capecitabine in patients with resectable gastric or gastro-oesophageal junction
adenocarcinoma (FLOT4-AIO): results from the phase 2 part of a multicentre,
open-label, randomised phase 2/3 trial. Lancet Oncol. 2016 Oct 21. pii:
S1470-2045(16)30531-9.
Lu LL, Chung AW, Rosebrock TR, Ghebremichael M, Yu WH, Grace PS, Schoen MK, Tafesse F, Martin C, Leung V, Mahan AE, Sips M, Kumar MP, Tedesco J, Robinson H, Tkachenko E, Draghi M, Freedberg KJ, Streeck H, Suscovich TJ, Lauffenburger DA, Restrepo BI, Day C, Fortune SM, Alter G. A Functional Role for Antibodies in Tuberculosis. Cell. Cell 2016 Oct 6;167(2):433-443.e14.
Dahms SO, Arciniega M, Steinmetzer T, Huber R, Than ME. Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism. Proc Natl Acad Sci U S A2016 Oct 4;113(40):11196-11201.
Li M, Radić Stojković M, Ehlers M, Zellermann E, Piantanida I, Schmuck C. Use of an Octapeptide-Guanidiniocarbonylpyrrole Conjugate for the Formation of a Supramolecular β-Helix that Self-Assembles into pH-Responsive Fibers. Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13015-13018.
Pekgöz Altunkaya G, Malvezzi F, Demianova Z, Zimniak T, Litos G, Weissmann F,
Mechtler K, Herzog F,
Westermann S. CCAN Assembly Configures Composite Binding
Interfaces to Promote Cross-Linking of Ndc80 Complexes at the Kinetochore. Curr Biol. 2016 Sep 12;26(17):2370-8.
Buiting K, Williams C, Horsthemke B. Angelman syndrome - insights into a rare neurogenetic disorder. Nat Rev Neurol. 2016 Oct;12(10):584-93. Review.
Hauschild A, Schadendorf D. Checkpoint inhibitors: a new standard of care for advanced Merkel cell carcinoma? Lancet Oncol. 2016 Sep 1. pii: S1470-2045(16)30441-7.
Weir JR, Faesen AC, Klare K, Petrovic A, Basilico F, Fischböck J, Pentakota S, Keller J, Pesenti ME, Pan D, Vogt D, Wohlgemuth S, Herzog F, Musacchio A. Insights from biochemical reconstitution into the architecture of human kinetochores. Nature. 2016 Aug 31;537(7619):249-253.
Carapito R,et al. Matching for the non-conventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD. Blood. 2016 Aug 22. pii: blood-2016-05-719070.
Seifert M, Küppers R. Human memory B cells. Leukemia. 2016 Aug 26. doi: 10.1038/leu.2016.226. Review.
Bitzer M, Horger M, Giannini EG, Ganten TM, Wörns MA, Siveke JT, Dollinger MM, Gerken G, Scheulen ME, Wege H, Zagonel V, Cillo U, Trevisani F, Santoro A, Montesarchio V, Malek NP, Holzapfel J, Herz T, Ammendola AS, Pegoraro S, Hauns B, Mais A, Lauer UM, Henning SW and Hentsch B. Resminostat plus sorafenib as second-line therapy of advanced hepatocellular carcinoma - The SHELTER study J Hepatol 65: 280-288, 2016.
Streich C, Akkari L, Decker C, Bormann J, Rehbock C, Müller-Schiffmann A,
Niemeyer FC, Nagel-Steger L, Willbold D, Sacca B, Korth C, Schrader T,
Barcikowski S. Characterizing the Effect of Multivalent Conjugates Composed of Aβ-Specific Ligands and Metal Nanoparticles on Neurotoxic Fibrillar Aggregation. ACS Nano. 2016 Aug 23; 10(8): 7582-97.
Klingberg A, Hasenberg A, Ludwig-Portugall I, Medyukhina A, Männ L, Brenzel A, Engel DR, Figge MT, Kurts C, Gunzer M. Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy. J Am Soc Nephrol. 2016 Aug 3. pii: ASN.2016020232.
Männ L, Kochupurakkal N, Martin C, Verjans E, Klingberg A, Sody S, Kraus A, Dalimot J, Bergmüller E, Jung S, Voortman S, Winterhager E, Brandau S, Garbi N, Kurrer M, Eriksson U, Gunzer M*, Hasenberg M*. CD11c.DTR mice develop a fatal fulminant myocarditis after local or systemic treatment with diphtheria toxin. Eur J Immunol. 2016 Aug;46(8):2028-42. (*senior authors)
Esser D, Hoffmann L, Pham TK, Bräsen C, Qiu W, Wright PC, Albers SV, Siebers B. Protein phosphorylation and its role in archaeal signal transduction. FEMS
Microbiol Rev. 2016 Sep;40(5):625-47. Review.
Hampp S, Kiessling T, Buechle K, Mansilla SF, Thomale J, Rall M, Ahn J, Pospiech H, Gottifredi V, Wiesmüller L. DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4311-9.
Crivello P, Heinold A, Rebmann V, Ottinger HD,Horn PA, Beelen DW, Fleischhauer K. Functional distance between recipient and donor HLA-DPB1 determines non-permissive mismatches in unrelated HCT. Blood. 2016 Jul 7;128(1):120-9.
von der Ecken J, Heissler SM, Pathan-Chhatbar S, Manstein DJ, Raunser S.Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic
resolution. Nature. 2016 Jun 30;534(7609):724-8.
Moses K, Klein JC, Männ L, Klingberg A, Gunzer M, Brandau S. Survival of residual neutrophils and accelerated myelopoiesis limit the efficacy of antibody-mediated depletion of Ly-6G+ cells in tumor-bearing mice. J Leukoc Biol. 2016 Jun;99(6):811-23.
Beyer M, Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y,
Shinde PV, Schmidleithner L, Köhne M, Trebicka J, Schierwagen R, Hofmann A, Popov
A, Lang KS, Oxenius A, Buch T, Kurts C, Heikenwalder M, Fätkenheuer G, Lang PA,
Hartmann P, Knolle PA, Schultze JL. Tumor-necrosis factor impairs CD4(+) T
cell-mediated immunological control in chronic viral infection. Nat Immunol.2016 May;17(5):593-603.
Wirsdörfer F, de Leve S, Cappuccini F, Eldh T, Meyer AV, Gau E, Thompson LF,
Chen NY, Karmouty-Quintana H, Fischer U, Kasper M, Klein D, Ritchey JW, Blackburn
MR, Westendorf AM, Stuschke M, Jendrossek V. Extracellular adenosine production
by ecto-5'-nucleotidase (CD73) enhances radiation-induced lung fibrosis. Cancer Res. 2016 May 15;76(10):3045-56.
Weissmann F, Petzold G, VanderLinden R, Huis In 't Veld PJ, Brown NG, Lampert
F, Westermann S, Stark H, Schulman BA, Peters JM. biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes. Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2564-9.
Kim DW, Mehra R, Tan DS, Felip E, Chow LQ, Camidge DR, Vansteenkiste J, Sharma
S, De Pas T, Riely GJ, Solomon BJ, Wolf J, Thomas M, Schuler M, Liu G, Santoro A,
Sutradhar S, Li S, Szczudlo T, Yovine A, Shaw AT. Activity and safety of
ceritinib in patients with ALK-rearranged non-small-cell lung cancer (ASCEND-1):
updated results from the multicentre, open-label, phase 1 trial. Lancet Oncol.2016 Apr;17(4):452-63.
Friese A, Faesen AC, Huis in 't Veld PJ, Fischböck J, Prumbaum D, Petrovic A,
Raunser S, Herzog F, Musacchio A. Molecular requirements for the inter-subunit
interaction and kinetochore recruitment of SKAP and Astrin. Nat Commun. 2016 Apr 20;7:11407.
Borisy G, Heald R, Howard J, Janke C, Musacchio A, Nogales E. Microtubules: 50
years on from the discovery of tubulin. Nat Rev Mol Cell Biol. 2016 Apr 22;17(5):322-8.
Kaur A et.al. sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance. Nature 2016 Apr 14;532(7598):250-4.
Kim DW, Mehra R, Tan DS, Felip E, Chow LQ, Camidge DR, Vansteenkiste J, Sharma
S, De Pas T, Riely GJ, Solomon BJ, Wolf J, Thomas M, Schuler M, Liu G, Santoro A,
Sutradhar S, Li S, Szczudlo T, Yovine A, Shaw AT. Activity and safety of
ceritinib in patients with ALK-rearranged non-small-cell lung cancer (ASCEND-1):
updated results from the multicentre, open-label, phase 1 trial. Lancet Oncol.2016 Apr;17(4):452-63.
McGranahan N, Furness AJ, Rosenthal R, Ramskov S, Lyngaa R, Saini SK,
Jamal-Hanjani M, Wilson GA, Birkbak NJ, Hiley CT, Watkins TB, Shafi S, Murugaesu
N, Mitter R, Akarca AU, Linares J, Marafioti T, Henry JY, Van Allen EM, Miao D,
Schilling B, Schadendorf D, Garraway LA, Makarov V, Rizvi NA, Snyder A, Hellmann
MD, Merghoub T, Wolchok JD, Shukla SA, Wu CJ, Peggs KS, Chan TA, Hadrup SR,
Quezada SA, Swanton C. Clonal neoantigens elicit T cell immunoreactivity and
sensitivity to immune checkpoint blockade. Science. 2016 Mar 25;351(6280):1463-9.
Oakes CC, Seifert M, Assenov Y, Gu L, Przekopowitz M, Ruppert AS, Wang Q,
Imbusch CD, Serva A, Koser SD, Brocks D, Lipka DB, Bogatyrova O, Weichenhan D,
Brors B, Rassenti L, Kipps TJ, Mertens D, Zapatka M, Lichter P, Döhner H, Küppers
R, Zenz T, Stilgenbauer S, Byrd JC, Plass C. DNA methylation dynamics during B
cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic
leukemia. Nat Genet. Mar;48(3):253-64.
Wang-Gillam A, Li CP, Bodoky G, Dean A, Shan YS, Jameson G, Macarulla T, Lee
KH, Cunningham D, Blanc JF, Hubner RA, Chiu CF, Schwartsmann G,Siveke JT,
Braiteh F, Moyo V, Belanger B, Dhindsa N, Bayever E, Von Hoff DD, Chen LT;
NAPOLI-1 Study Group. Nanoliposomal irinotecan with fluorouracil and folinic acid
in metastatic pancreatic cancer after previous gemcitabine-based therapy
(NAPOLI-1): a global, randomised, open-label, phase 3 trial. Lancet. 2016 Feb
6;387(10018):545-57.
Zec K, Volke J, Vijitha N, Thiebes S, Gunzer M, Kurts C, Engel DR. Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages. Pathogens. 2016 Feb 4;5(1).
Hönes JM, Botezatu L, Helness A, Vadnais C, Vassen L, Robert F, Hergenhan SM, Thivakaran A, Schütte J, Al-Matary YS, Lams RF, Fraszscak J, Makishima H, Radivoyevitch T, Przychodzen B, da Conceição Castro SV, Görgens A, Giebel B, Klein-Hitpass L, Lennartz K, Heuser M, Thiede C, Ehninger G,Dührsen U, Maciejewski J, Möröy T, Khandanpour C. GFI1 as a novel prognostic and therapeutic
factor for AML/MDS. Leukemia. 2016 Jun;30(6):1237-45.
Rolle AM, Hasenberg M*, Thornton CR, Solouk-Saran D, Männ L, Weski J, Maurer A, Fischer E, Spycher PR, Schibli R, Boschetti F, Stegemann-Koniszewski S, Bruder D, Severin GW, Autenrieth SE, Krappmann S, Davies G, Pichler BJ, Gunzer M**, Wiehr S. ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1026-33, **corresponding senior author.
Yao JC et.al., Fourth Trial (RADIANT-4) Study Group. Everolimus
for the treatment of advanced, non-functional neuroendocrine tumours of the lung
or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3
study. Lancet. 2016 Mar 5;387(10022):968-77.
Costa P, Lohmiller T, Trosien I, Savitsky A, Lubitz W, Fernandez-Oliva M,
Sanchez-Garcia E, Sander W. Light and Temperature Control of the Spin State of Bis(p-methoxyphenyl)carbene: A Magnetically Bistable Carbene. J Am Chem Soc. 2016 Feb 10;138(5):1622-9.
Henkel S, Costa P, Klute L, Sokkar P, Fernandez-Oliva M, Thiel W,
Sanchez-Garcia E, Sander W. Switching the Spin State of Diphenylcarbene via Halogen Bonding. J Am Chem Soc. 2016 Feb 10;138(5):1689-97.
Schultz BT, Teigler JE, Pissani F, Oster AF, Kranias G, Alter G, Marovich M, Eller MA, Dittmer U, Robb ML, Kim JH, Michael NL, Bolton D, Streeck H. Circulating HIV-Specific Interleukin-21+CD4+ T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions. Immunity 2016 Jan 19;44(1):167-78.
Li M, Ehlers M, Schlesiger S, Zellermann E, Knauer SK, Schmuck C. Incorporation of a Non-Natural Arginine Analogue into a Cyclic Peptide Leads to Formation of Positively Charged Nanofibers Capable of Gene Transfection. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):598-601.
