Welcome to ZMB

Welcome to ZMB

The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.

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News & Events

© UDE

Unikate 56 "Junge Wilde" - die nächste Generation

Die neue Ausgabe der Unikate stellt eine Reihe "Junger Wilder", exemplarisch für die vielen jungen Forscher*innen an unserer Universität, in den Mittelpunkt. Mit dabei aus den Reihen unserer ZMB Mitglieder sind Barbara M. Grüner, Doris Hellerschmied-Jelinek, Jochen Niemeyer und Jens Voskuhl, die über ihre Forschungsthemen berichten und diese für fachfremde Leser*innen und für die Öffentlichkeit erfahrbar machen.

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Autophagy in Cancer Guest Editor Silvia Vega-Rubín-de-Celis

[07.04.2021] The prestigious journal "Frontiers in Cell and Developmental Biology" invited Dr. Silvia Vega-Rubín-de-Celis as Guest Editor for a Research Topic on "Molecular Mechanisms of Autophagy in Cancer". According to Vega-Rubín-de-Celis and her co-Topic Editors it will focus on recent advances in understanding multiple aspects of autophagy regulation in cancer and its role in tumorigenesis.
The call for submissions is now open (download flyer).

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Am 28.04.2021 Auf zu neuen Kooperationen

Virtuelles Seminar zum Austausch der Disziplinen: Gemeinsamkeiten erkennen, Potenziale nutzen, zusammen forschen!

Ziel des Seminars ist es, Forschende von ZMB, Cenide und der Medizinischen Fakultät einander bekannter zu machen und ihren Austausch zu fördern. Neben Kurzvorträgen zu bereits erfolgreichen Kooperationen, werden sich auch Kolleg*Innen vorstellen, die nach Kooperationspartner*innen oder Anknüpfungspunkten suchen.

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© UDE/Med.-Fak.

17. & 18. Juni 2021 Winterseminar Reloaded

Am 17. & 18. Juni 2021 veranstaltet die Medizinische Fakultät das virtuelle Winterseminar Interdisziplinär Reloaded – WIR.
Hier haben die Kooperationspartner*innen von bis zu 10 Projektideen die Möglichkeit, sich zu präsentieren. Eine Gutachterjury der Medizinischen Fakultät wählt dann bis zu 4 Projekte aus, die sich über einen Zuschuss von insgesamt 90.000€ freuen dürfen.

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Press Releases 2020/2021

© UDE/Frank Preuß

Neu am ZMB: Katharina Lückerath Tumore überlisten

[31.03.2021] Nur wer Tumore im Detail versteht, kann sie optimal behandeln. Dr. Katharina Lückerath vom UK Essen erforscht, wie ihre biologischen Prozesse ablaufen. Die neue Professorin für Präklinische Nuklearmedizinische Theranostik entwickelt an der Medizinischen Fakultät der UDE neue Ansätze für Radionuklidtherapien und bildgebende Verfahren.

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© UDE/Sánchez-García

Success of Interdisciplinary Collaboration Switching Off the Survival Protein for Cancer Cells

[8.03.2021] It is called the "survival protein" because it plays a central role in the growth of cancer cells: survivin influences two important processes in the body's cells at the same time – cell death and cell division. Chemists and biologists at the UDE have now succeeded in developing a precise molecule that can bind the protein’s surface at a defined site and switch it off. "Nature Communications" covers the topic.

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© HUST

Cooperation UDE / Wuhan One of the most important publications on COVID-19

[18.01.2021] One of the world's most important publications on COVID-19 was written in cooperation with the medical faculty and scientific partners in Wuhan (China). It was published in April 2020 and describes important changes in the immune system of those affected. Eight months later, the relevance of the study becomes apparent: It is one of the most cited publications on the subject worldwide.

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Nationwide Network University Medicine Funding for COVID-19 research in Essen approved

[08.01.2021] Clinics and institutes of the University Hospital Essen that collect and analyze disease data and samples from COVID-19 patients are supported by the German Federal Ministry of Education and Research (BMBF) with 895,000€ until the end of this year. The joint goal of the researchers and clinicians is to formulate new research questions and answer existing ones.

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DFG funds immune cell study Covid-19: Better understanding of defense cells

[21.12.2020] In a study, researchers from the Faculty of Medicine are investigating the role played by certain immune cells in the fight against SARS-CoV-2 and why some of them last longer than others. Their findings could become particularly important for the treatment and vaccination of the population against COVID-19. The German Research Foundation (DFG) is funding the project for one year with 38,000 euros through a COVID-19 emergency program.

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© IZTF

Treatment of blood disorders Immune mechanism discovered

[03.12.2020] Researchers from the Medical Faculty of the UDE and the German Consortium for Translational Cancer Research (DKTK) at the partner location Essen/Düsseldorf have been able to explain a new mechanism in the human immune system. On the basis of their results, new approaches can be studied to improve the therapeutic success of blood stem cell transplants. The German-Dutch study was published in the renowned journal Blood.

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© UK Essen/Detlef Kittel

SARS-CoV-2 UV light inactivates corona viruses

[01.09.2020] SARS-CoV-2 viruses can be completely inactivated with ultraviolet light. This was shown of Virologyby a promising study by ZMB member PD Dr. Adalbert Krawczyk (photo) and Dr. Christiane Heilingloh from the Institute at the University Hospital Essen. The American Journal of Infection Control is now reporting on this. Their research was funded by the University Medicine Essen Foundation and the Rudolf Ackermann Foundation.

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DFG Research Grant for Virkramjeet Singh Feedback loops between gut microbes and immune cells may impact outcome after stroke

[10.06.2020] The DFG approved funding for an exciting new research project of Dr. Vikramjeet Singh that targets at exploring how the interaction with gut microbiota shapes the impact of neutrophils on ischemic brain injury. Singh is principal investigator at the Institute of Experimental Immunology and Imaging at the University Hospital Essen. Working as postdoc at the Institute for Stroke and Dementia Research at the LMU Medical Center, Singh and his colleagues identified a bidirectional communication along the brain–gut microbiota–immune axis and could show that the gut microbiota is a potentially central regulator of immune homeostasis.

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Erkenntnisse für Test und Impfstoffe Neue Details der Immunantwort bei Covid-19

[22.05.2020] Das menschliche Immunsystem reagiert auf mehr als nur das bisher fokussierte Virusprotein. Das ist bedeutend für Tests und mögliche Impfstoffe. Forschungsteams der Ruhr-Universität Bochum (RUB) und der Medizinischen Fakultät der UDE am Universitätsklinikums Essen haben herausgefunden, auf welche Teile des Sars-Cov-2-Virus das menschliche Immunsystem reagiert: Neben dem bisher fokussierten Spike-Protein können auch zwei weitere Proteine eine starke Immunantwort auslösen.

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ZMB Research Programs

Oncology

The concept of this research program is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments.

Participating researchers from biology, experimental and clinical medicine study tumors as “biological systems" and so called “neo-organs”.

A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.

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Immunology, Infectious Diseases and Transplantation

The immune system responds to various pathogens including viruses and bacteria in different ways to prevent severe disease and persistence in the host. Many pathogens, however, have developed mechanisms to evade immune defence.

The molecular and cellular interactions of pathogens with the immune system are studied within this program.

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Molecular and Chemical Cell Biology

Molecular and chemical cell biology is an interdisciplinary research program connecting molecular cell biology and genetics with chemistry and structural biology. Scientists of the participating disciplines collaborate to advance the understanding of basic molecular mechanisms of important biological processes.

The analysis of regulation and deregulation of key pathways is linking basic biology with pathophysiology.

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Latest Publications

    Journal articles

  • Kohlhaas, Vivien; Blakemore, Stuart James; Al-Maarri, Mona; Nickel, Nadine; Pal, Martin; Roth, Andreas; Hövelmeyer, Nadine; Schäfer, Stephan C.; Knittel, Gero; Lohneis, Philipp; Nikolic, Milos; Wiederstein, Janica L.; Franitza, Marek; Georgomonolis, Theodoros; Reinart, Nina; Herling, Marco; Herling, Carmen; Hartmann, Elena M.; Rosenwald, Andreas; Klapper, Wolfram; Büttner, Reinhard; Moia, Riccardo; Rossi, Davide; Boldorini, Renzo; Gaidano, Gianluca; Frenzel, Lukas P.; Reinhardt, Christian; Brüning, Jens C.; Hallek, Michael; Krüger, Marcus; Peifer, Martin; Pallasch, Christian P.; Wunderlich, F. Thomas
    Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1
    In: Blood Vol. 137 (2021) Nr. 5, pp. 646 - 660
    ISSN: 1528-0020; 0006-4971
  • Wettstein, Lukas; Weil, Tatjana; Conzelmann, Carina; Müller, Janis A.; Groß, Rüdiger; Hirschenberger, Maximilian; Seidel, Alina; Klute, Susanne; Zech, Fabian; Prelli Bozzo, Caterina; Preising, Nico; Fois, Giorgio; Lochbaum, Robin; Knaff, Philip Maximilian; Mailänder, Volker; Ständker, Ludger; Thal, Dietmar Rudolf; Schumann, Christian; Stenger, Steffen; Kleger, Alexander; Lochnit, Günter; Mayer, Benjamin; Ruiz-Blanco, Yasser B.; Hoffmann, Markus; Sparrer, Konstantin M. J.; Pöhlmann, Stefan; Sanchez-Garcia, Elsa; Kirchhoff, Frank; Frick, Manfred; Münch, Jan
    Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1726
    ISSN: 2041-1723
  • Chuang, Chen-Hua; Dorsch, Madeleine; Dujardin, Philip; Silas, Sukrit; Ueffing, Kristina; Hölken, Johanna M; Yang, Dian; Winslow, Monte M.; Grüner, Barbara M.
    Altered mitochondria functionality defines a metastatic cell state in lung cancer and creates an exploitable vulnerability
    In: Cancer Research Vol. 81 (2021) Nr. 3, pp. 567 - 579
    ISSN: 0008-5472; 1538-7445
  • Henneberg, Sophie; Hasenberg, Anja; Maurer, Andreas; Neumann, Franziska; Bornemann, Lea; Gonzalez-Menendez, Irene; Kraus, Andreas; Hasenberg, Mike; Thornton, Christopher R.; Pichler, Bernd J.; Gunzer, Matthias; Beziere, Nicolas
    Antibody-guided in vivo imaging of Aspergillus fumigatus lung infections during antifungal azole treatment
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1707
    ISSN: 2041-1723
  • Singh, Priyanka; Pesenti, Marion E.; Maffini, Stefano; Carmignani, Sara; Hedtfeld, Marius; Petrovic, Arsen; Srinivasamani, Anupallavi; Bange, Tanja; Musacchio, Andrea
    BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis
    In: Molecular Cell Vol. 81 (2021) Nr. 1, pp. 67 - 87.e9
    ISSN: 1097-4164; 1097-2765
  • van Sorge, Nina M.; Bonsor, Daniel A.; Deng, Liwen; Lindahl, Erik; Schmitt, Verena; Lyndin, Mykola; Schmidt, Alexej; Nilsson, Olof R.; Brizuela, Jaime; Boero, Elena; Sundberg, Eric J.; van Strijp, Jos A. G.; Doran, Kelly S.; Singer, Bernhard B.; Lindahl, Gunnar; McCarthy, Alex J.
    Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors
    In: The EMBO Journal (2021) in press
    ISSN: 1460-2075; 0261-4189
  • Piano, Valentina; Alex, Amal; Stege, Patricia; Maffini, Stefano; Stoppiello, Gerardo A.; Huis In'T Veld, Pim J.; Vetter, Ingrid R.; Musacchio, Andrea
    CDC20 assists its catalytic incorporation in the mitotic checkpoint complex
    In: Science Vol. 371 (2021) Nr. 6524, pp. 67 - 71
    ISSN: 1095-9203; 0036-8075
  • Schuler, Martin
    Corrigendum to “Inhibiting fibroblast growth factor receptors in cancer – The next generation”
    In: Annals of Oncology Vol. 32 (2021) Nr. 1, pp. 126
    ISSN: 1569-8041; 0923-7534
  • Chen, Jieliang; Li, Yaming; Lai, Fritz; Wang, Yang; Sutter, Kathrin; Dittmer, Ulf; Ye, Jianyu; Zai, Wenjing; Liu, Min; Shen, Fang; Wu, Min; Hu, Kongying; Li, Baocun; Lu, Mengji; Zhang, Xiaonan; Zhang, Jiming; Li, Jianhua; Chen, Qingfeng; Yuan, Zhenghong
    Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ Signaling
    In: Hepatology Vol. 73 (2021) Nr. 2, pp. 486 - 502
    ISSN: 1527-3350; 0270-9139
  • Bénard, Alan; Jacobsen, Anne; Brunner, Maximilian; Krautz, Christian; Klösch, Bettina; Swierzy, Izabela; Naschberger, Elisabeth; Podolska, Malgorzata J.; Kouhestani, Dina; David, Paul; Birkholz, Torsten; Castellanos, Ixchel; Trufa, Denis; Sirbu, Horia; Vetter, Marcel; Kremer, Andreas E.; Hildner, Kai; Hecker, Andreas; Edinger, Fabian; Tenbusch, Matthias; Mühl-Zürbes, Petra; Steinkasserer, Alexander; Richter, Enrico; Streeck, Hendrik; Berger, Marc M.; Brenner, Thorsten; Weigand, Markus A.; Swirski, Filip K.; Schett, Georg; Grützmann, Robert; Weber, Georg F.
    Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1112
    ISSN: 2041-1723
  • Weniger, Marc; Küppers, Ralf
    Molecular biology of Hodgkin lymphoma
    In: Leukemia (2021) in press
    ISSN: 1476-5551; 0887-6924
  • Frangieh, Chris J.; Melms, Johannes C.; Thakore, Pratiksha I.; Geiger-Schuller, Kathryn R.; Ho, Patricia; Luoma, Adrienne M.; Cleary, Brian; Jerby-Arnon, Livnat; Malu, Shruti; Cuoco, Michael S.; Zhao, Maryann; Ager, Casey R.; Rogava, Meri; Hovey, Lila; Rotem, Asaf; Bernatchez, Chantale; Wucherpfennig, Kai W.; Johnson, Bruce E.; Rozenblatt-Rosen, Orit; Schadendorf, Dirk; Regev, Aviv; Izar, Benjamin
    Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion
    In: Nature Genetics Vol. 53 (2021) Nr. 3, pp. 332 - 341
    ISSN: 1061-4036; 1546-1718
  • Kunzmann, Volker; Siveke, Jens; Algül, Hana; Goekkurt, Eray; Siegler, Gabriele; Martens, Uwe; Waldschmidt, Dirk; Pelzer, Uwe; Fuchs, Martin; Kullmann, Frank; Boeck, Stefan; Ettrich, Thomas J; Held, Swantje; Keller, Ralph; Klein, Ingo; Germer, Christoph-Thomas; Stein, Hubert; Friess, Helmut; Bahra, Marcus; Jakobs, Ralf; Hartlapp, Ingo; Heinemann, Volker; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators; Stahl, Michael; Mahlmann, Stefan
    Nab-paclitaxel plus gemcitabine versus nab-paclitaxel plus gemcitabine followed by FOLFIRINOX induction chemotherapy in locally advanced pancreatic cancer (NEOLAP-AIO-PAK-0113) : a multicentre, randomised, phase 2 trial
    In: The Lancet Gastroenterology & Hepatology Vol. 6 (2021) Nr. 2, pp. 128 - 138
    ISSN: 2468-1253
  • Heming, Michael; Li, Xiaolin; Räuber, Saskia; Mausberg, Anne K.; Börsch, Anna-Lena; Hartlehnert, Maike; Singhal, Arpita; Lu, I-Na; Fleischer, Michael; Szepanowski, Fabian; Witzke, Oliver; Brenner, Thorsten; Dittmer, Ulf; Yosef, Nir; Kleinschnitz, Christoph; Wiendl, Heinz; Stettner, Mark; Meyer zu Hörste, Gerd
    Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid
    In: Immunity Vol. 54 (2021) Nr. 1, pp. 164
    ISSN: 1097-4180; 1074-7613
  • Mueller, Franziska; Friese, Alexandra; Pathe, Claudio; da Silva, Richard Cardoso; Bravo Rodriguez, Kenny; Musacchio, Andrea; Bange, Tanja
    Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization
    In: Science Advances Vol. 7 (2021) Nr. 3, pp. eabc8590
    ISSN: 2375-2548
  • Lorentino, Francesca; Labopin, Myriam; Ciceri, Fabio; Vago, Luca; Fleischhauer, Katharina; Afanasyev, Boris; Kröger, Nicolaus; Cornelissen, Jan J.; Lovira, Montserrat; Meijer, Ellen; Vitek, Antonin; Elmaagacli, Ahmet; Blaise, Didier; Ruggeri, Annalisa; Chabannon, Christian; Nagler, Arnon; Mohty, Mohamad
    Post-transplantation cyclophosphamide GvHD prophylaxis after hematopoietic stem cell transplantation from 9/10 or 10/10 HLA-matched unrelated donors for acute leukemia
    In: Leukemia Vol. 35 (2021) Nr. 2, pp. 585 - 594
    ISSN: 1476-5551; 0887-6924
  • Grunewald, Susanne; Klug, Lillian R.; Mühlenberg, Thomas; Lategahn, Jonas; Falkenhorst, Johanna; Town, Ajia; Ehrt, Christiane; Wardelmann, Eva; Hartmann, Wolfgang; Schildhaus, Hans-Ulrich; Treckmann, Jürgen Walter; Fletcher, Jonathan A.; Jung, Sascha; Czodrowski, Paul; Miller, Stephen; Schmidt-Kittler, Oleg; Rauh, Daniel; Heinrich, Michael C.; Bauer, Sebastian
    Resistance to avapritinib in pdgfra-driven gist is caused by secondary mutations in the pdgfra kinase domain
    In: Cancer Discovery Vol. 11 (2021) Nr. 1, pp. 108 - 125
    ISSN: 2159-8290; 2159-8274
  • Obermann, Mark; Nägel, Steffen; Ose, Claudia; Sonuc, Nilüfer; Scherag, Andre; Storch, Peter; Gaul, Charly; Böger, Andreas; Kraya, Torsten; Jansen, Jan-Peter; Straube, Andreas; Freilinger, Tobias; Kaube, Holger; Jürgens, Tim P; Diener, Hans Christoph; Katsarava, Zaza; Kleinschnitz, Christoph; Holle, Dagny
    Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache : A multicentre, double-blind, randomised controlled trial
    In: The Lancet Neurology Vol. 20 (2021) Nr. 1, pp. 29 - 37
    ISSN: 1474-4465; 1474-4422
  • Meiners, Annika; Bäcker, Sandra; Hadrovic, Inesa; Heid, Christian; Beuck, Christine; Ruiz-Blanco, Yasser B.; Mieres-Perez, Joel; Pörschke, Marius; Grad, Jean-Noël; Vallet, Cecilia; Hoffmann, Daniel; Bayer, Peter; Sanchez-Garcia, Elsa; Schrader, Thomas; Knauer, Shirley
    Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1505
    ISSN: 2041-1723
  • Lee, Jung-Hoon; Bollschweiler, Daniel; Schäfer, Tillman; Huber, Robert
    Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies
    In: Science Advances Vol. 7 (2021) Nr. 2, pp. eabd4413
    ISSN: 2375-2548
  • Somasundaram, Rajasekharan; Connelly, Thomas; Choi, Robin; Choi, Hyeree; Samarkina, Anastasia; Li, Ling; Gregorio, Elizabeth; Chen, Yeqing; Thakur, Rohit; Abdel-Mohsen, Mohamed; Beqiri, Marilda; Kiernan, Meaghan; Perego, Michela; Wang, Fang; Xiao, Min; Brafford, Patricia; Yang, Xue; Xu, Xiaowei; Secreto, Anthony; Danet-Desnoyers, Gwenn; Traum, Daniel; Kaestner, Klaus H.; Huang, Alexander C.; Hristova, Denitsa; Wang, Joshua; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Ping-Chen, Fang; Zhou, Xiangyang; Gutierrez, Alexis; Rebecca, Vito W.; Vonteddu, Prashanthi; Dotiwala, Farokh; Bala, Shashi; Majumdar, Sonali; Dweep, Harsh; Wickramasinghe, Jayamanna; Kossenkov, Andrew V.; Reyes-Arbujas, Jorge; Santiago, Kenisha; Nguyen, Tran; Griss, Johannes; Keeney, Frederick; Hayden, James; Gavin, Brian J.; Weiner, David; Montaner, Luis J.; Liu, Qin; Peiffer, Lukas; Becker, Jürgen; Burton, Elizabeth M.; Davies, Michael A.; Tetzlaff, Michael T.; Muthumani, Kar; Wargo, Jennifer A.; Gabrilovich, Dmitry; Herlyn, Meenhard
    Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 346
    ISSN: 2041-1723
  • Cao, Yingying; Kitanovski, Simo; Küppers, Ralf; Hoffmann, Daniel
    UMI or not UMI, that is the question for scRNA-seq zero-inflation
    In: Nature Biotechnology Vol. 39 (2021) Nr. 2, pp. 158 - 159
    ISSN: 1087-0156; 1546-1696; 0733-222X