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The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.

University of Duisburg-Essen:
Corona Virus Current Information

Behandlung von Blutkrankheiten Immun-Mechanismus entdeckt


© IZTF

[03.12.2020] Forschende der Medizinischen Fakultät der UDE und des Deutschen Konsortiums für Translationale Krebsforschung (DKTK) am Partnerstandort Essen/Düsseldorf haben einen neuen Mechanismus im menschlichen Immunsystem erklären können. Ihre Ergebnisse tragen dazu bei, bösartige Bluterkrankungen wie Leukämie künftig besser zu behandeln. Die deutsch-niederländische Studie ist in der renommierten Fachzeitschrift Blood publiziert worden.

Meurer T, Crivello P, Metzing MF, Kester M, Megger DA, Chen W, van Veelen PA, van Balen P, Westendorf A, Homa G, Layer SE, Turki AT, Griffioen M, Horn PA, Sitek B, Beelen DW, Falkenburg JHF, Arrieta-Bolaños E, Fleischhauer K.
Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM.
Blood. 2020 Sep 6:blood.2020008464. Online ahead of print.

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Neue Heisenberg Professur Verzahnte Moleküle als Katalysatoren


© UDE/Frank Preuß

[03.12.2020]  Nicht direkt verbunden, aber untrennbar: Verzahnte Moleküle sind wie Glieder einer Kette oder wie ein Ring auf einem Faden miteinander verwoben. ZMB Member Dr. Jochen Niemeyer erforscht an der Fakultät für Chemie der UDE, wie sie angewendet werden. Den neuen Heisenberg-Professor für Organische und Supramolekulare Chemie interessiert besonders ihr Einsatz als Katalysatoren.

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Neuer Sonderforschungsbereich bewilligt

Wie werden Schilddrüsenhormone lokal kontrolliert?

[29.05.2020] Im Fokus des neu eingerichteten SFB/Transregio 296 „Local Control of Thyroid Hormone Action“ (LOCOTACT) stehen in den nächsten vier Jahren die Wirkungen von Schilddrüsenhormonen in den Organen Gehirn, Leber und Herz. Die Wissenschaftler von LOCOTACT wollen herausfinden, wie vor Ort Transport, Stoffwechsel und Wirkmechanismus von Schilddrüsenhormonen in diesen Organen kontrolliert werden und welche Auswirkung eine Störung dieser Prozesse haben kann.

Dabei soll auch erforscht werden, inwieweit ein veränderter lokaler Schilddrüsenhormon-Status in diesen Geweben sich positiv bei „Volkserkrankungen“ wie z.B. der Fettleber auswirken kann. Sprecherin des Forschungsverbundes mit der Universität zu Lübeck und der Charité Berlin ist Prof. Dr. Dagmar Führer-Sakel, Direktorin der Klinik für Endokrinologie, Diabetologie und Stoffwechsel am UK Essen. Die DFG fördert den SFB für zunächst vier Jahre mit 13,7 Mio. Euro.

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© pixabay.com

Erkenntnisse für Test und Impfstoffe

Neue Details der Immunantwort bei Covid-19

[22.05.2020] Das menschliche Immunsystem reagiert auf mehr als nur das bisher fokussierte Virusprotein. Das ist bedeutend für Tests und mögliche Impfstoffe. Forschungsteams der Ruhr-Universität Bochum (RUB) und der Medizinischen Fakultät der UDE am Universitätsklinikums Essen haben herausgefunden, auf welche Teile des Sars-Cov-2-Virus das menschliche Immunsystem reagiert: Neben dem bisher fokussierten Spike-Protein können auch zwei weitere Proteine eine starke Immunantwort auslösen.

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© pixabay.com

Deutsch-chinesische Forschung

Schwere COVID-19-Verläufe früh erkennen

[30.04.2020] Viele COVID-19-Erkrankungen verlaufen mild. Aber etwa zehn Prozent der Erkrankten entwickeln eine schwere Lungenentzündung und benötigen intensivmedizinische Versorgung. Um frühzeitig die richtigen therapeutischen Schritte einleiten zu können, ist es wichtig, potentiell gefährdete Patienten zu identifizieren. Gemeinsam mit chinesischen Kollegen am Wuhan Union Hospital haben Wissenschaftler des Instituts für Virologie der Medizinischen Fakultät der UDE festgestellt, dass die T-Zell-Population ein wichtiger Indikator ist. Diese Studie ist jetzt in The Lancet EBiomedicine online veröffentlicht.

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Schilddrüse beeinflusst Hirnleistung stärker als gedacht

Gut fürs Gedächtnis

[17.04.2020] Schilddrüsenhormone fördern unmittelbar die Bildung von Nervenzellen im Lern- und Gedächtniszentrum des Gehirns. Das belegen Forschungen der Medizinischen Fakultät der UDE und der University of Edinburgh erstmals. Die Ergebnisse liefern neben wichtigen Grundlagenerkenntnissen auch neue Ansatzpunkte, wie die geistige Leistungsfähigkeit mithilfe der Medizin verbessert werden kann. Das renommierte Stem Cell Reports berichtet.

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Freerangestock-photo 76280 20160913
© freerangestock.com

EU-Projekt zu Corona-Impfstoff

Antivirale Wirkstoffe und neue Testmodelle

[16.03.2020] Das neuartige Coronavirus (SARS-CoV-2) hat weltweit bereits mehrere Tausend Todesopfer gefordert. Eine spezifische Therapie oder eine Schutzimpfung gibt es bisher nicht. In einem jetzt gestarteten EU-Projekt wollen Forschende um die Professoren Jan Münch von der Universität Ulm und Thomas Schrader (UDE) die Entwicklung einer wirksamen antiviralen Therapie beschleunigen.

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Brain Hirn C Pixabay
© pixabay.com

Schlaganfall-Studie

Erfolgsfaktoren identifiziert

  • 19.02.2020

Schlaganfälle zählen zu den häufigsten Todesursachen in Deutschland. Ein Team um Prof. Dr. Dirk M. Hermann von der Medizinischen Fakultät erforschte in einer dreijährigen Studie die am weitesten verbreiteten Variante: den Hirninfarkt. Die Ergebnisse wurden jetzt in The Lancet Neurology* veröffentlicht.

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Neues MERCUR Promotionskolleg startet Präzisionsprotonentherapie

Praxisbezogene Physik und Chemie an der Schnittstelle zur Medizin

[04.02.2020] Als moderne Methode der Präzisionsradiotherapie ermöglicht die Protonentherapie eine sehr präzise Behandlung von Tumoren. Insbesondere können damit Tumore in der Nähe von Risikoorganen und tiefliegende Tumore optimal behandelt werden, und sie setzt sich so von anderen Methoden der Radiotherapie klar ab. Die Grundlagen zur Erreichung der benötigten Präzision sind eine sehr gute Lokalisation des zu bestrahlenden Gewebes einerseits und die genaue Kenntnis der applizierten Dosis andererseits. Die damit verbundenen wissenschaftlichen Herausforderungen liegen an den Schnittstellen von Physik, Chemie und Medizin.

Mehr dazu (Pressemitteilung Mercator Research Center Ruhr)

Das Graduiertenkolleg ist eine Zusammenarbeit in Forschung und Lehre zwischen der Fakultät Physik der TU Dortmund, der Klinik für Partikeltherapie am Westdeutschen Protonentherapiezentrum (WPE) des UK Essen, der Medizinischen Fakultät der Universität Duisburg-Essen und CENIDE/ZMB Mitglied Stephan Barcikowski (Technischen Chemie I). Das Graduiertenkolleg wird gefördert von dem Mercator Research Center Ruhr (MERCUR).

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Zu geringe Dosis mit schweren Folgen Wenn der Hemmstoff aktiviert

© UDE/ZMB

[16.01.2020] Ein Wirkstoff soll eine Reaktion im Körper unterdrücken, stattdessen verstärkt er sie zusätzlich: Dieser Effekt kann zum Beispiel in der Krebstherapie fatal sein, wenn es darum geht, das unkontrollierte Wachstum erkrankter Zellen zu hemmen. Ein internationales Team unter Leitung der UDE hat nun eine Erklärung für diesen paradoxen Effekt gefunden.

Dass ein Medikament einen Prozess aktiviert, statt ihn wie geplant zu hemmen, geschieht vor allem dann, wenn der Wirkstoff in nur geringer Konzentration am Zielort ankommt und dort zudem mehrere potenzielle Bindestellen vorliegen. Das fanden Wissenschaftler um UDE-Professor Dr. Michael Ehrmann heraus und publizierten ihre Erkenntnisse im Fachjournal PNAS.

Siehe auch: Medizinische Hemmstoffe können bei zu geringer Dosis aktivieren

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Andrea Musacchio receives Leibniz Prize 2020

Andrea Musacchio
© MPI

[05.12.2019] Andrea Musacchio, Director of the Department of Mechanistic Cell Biology at the Max Planck Institute of Molecular Physiology, received the highest scientific award in Germany. The Gottfried Wilhelm Leibniz Prize, endowed with 2.5 million euro, honors his groundbreaking structural biology work on the distribution of chromosomes during cell division.

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Recent Publications

2020

Kollenda SA, Klose J, Knuschke T, Sokolova V, Schmitz J, Staniszewska M, Costa PF, Herrmann K, Westendorf AM, Fendler WP, Epple M. In vivo biodistribution of calcium phosphate nanoparticles after intravascular, intramuscular, intratumoral, and soft tissue administration in mice investigated by small animal PET/CT. Acta Biomater. 2020 Apr 3:S1742-7061(20)30172-0.

Wiesweg M, Schuler M, Schildhaus HU. Crizotinib in ROS1 and MET Deregulated NSCLC-Letter. Clin Cancer Res. 2020 Apr 1;26(7):1774.

Schuler M, Berardi R, Lim WT, de Jonge M, Bauer TM, Azaro A, Gottfried M, Han JY, Lee DH, Wollner M, Hong DS, Vogel A, Delmonte A, Akimov M, Ghebremariam S, Cui X, Nwana N, Giovannini M, Kim TM. Molecular correlates of response to capmatinib in advanced non-small-cell lung cancer: clinical and biomarker results from a Phase I trial. Ann Oncol. 2020 Mar 30:S0923-7534(20)36380-8.

Brenner E, Schörg BF, Ahmetlić F, Wieder T, Hilke FJ, Simon N, Schroeder C, Demidov G, Riedel T, Fehrenbacher B, Schaller M, Forschner A, Eigentler T, Niessner H, Sinnberg T, Böhm KS, Hömberg N, Braumüller H, Dauch D, Zwirner S, Zender L, Sonanini D, Geishauser A, Bauer J, Eichner M, Jarick KJ, Beilhack A, Biskup S, Döcker D, Schadendorf D, Quintanilla-Martinez L, Pichler BJ, Kneilling M, Mocikat R, Röcken M. Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours. Nat Commun. 2020 Mar 12;11(1):1335.

Lang J, Bohn P, Bhat H, Jastrow H, Walkenfort B, Cansiz F, Fink J, Bauer M, Olszewski D, Ramos-Nascimento A, Duhan V, Friedrich SK, Becker KA, Krawczyk A, Edwards MJ, Burchert A, Huber M, Friebus-Kardash J, Göthert JR, Hardt C, Probst HC, Schumacher F, Köhrer K, Kleuser B, Babiychuk EB, Sodeik B, Seibel J, Greber UF, Lang PA, Gulbins E, Lang KS. Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease. Nat Commun. 2020 Mar 12;11(1):1338.

Bazinet M, Pântea V, Placinta G, Moscalu I, Cebotarescu V, Cojuhari L, Jimbei P, Iarovoi L, Smesnoi V, Musteata T, Jucov A, Dittmer U, Krawczyk A, Vaillant A. Safety and Efficacy of 48 Weeks REP 2139 or REP 2165, Tenofovir Disoproxil, and Pegylated Interferon Alfa-2a in Patients With Chronic HBV Infection Naïve to Nucleos(t)ide Therapy. Gastroenterology. 2020 Mar 5:S0016-5085(20)30320-6.

Herrmann K, Schwaiger M, Lewis JS, Solomon SB, McNeil BJ, Baumann M, Gambhir SS, Hricak H, Weissleder R. Radiotheranostics: a roadmap for future development. Lancet Oncol. 2020 Mar;21(3):e146-e156.

Chabriat H, Bassetti CL, Marx U, Audoli-Inthavong ML, Sors A, Lambert E, Wattez M, Hermann DM; RESTORE BRAIN study investigators. Safety and efficacy of GABA<sub>A</sub> α5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet Neurol. 2020 Mar;19(3):226-233.

Shen L, Kohlhaas M, Enoki J, Meier R, Schönenberger B, Wohlgemuth R, Kourist R, Niemeyer F, van Niekerk D, Bräsen C, Niemeyer J, Snoep J, Siebers B. A combined experimental and modelling approach for the Weimberg pathway optimisation. Nat Commun. 2020 Feb 27;11(1):1098.

Global Retinoblastoma Study Group, Fabian ID et. al. Global Retinoblastoma Presentation and Analysis by National Income Level. JAMA Oncol. 2020 Feb 27:e196716. doi: 10.1001/jamaoncol.2019.6716. Epub ahead of print.

Köcher S, Resch S, Kessenbrock T, Schrapp L, Ehrmann M, Kaiser M. From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins: the chemical biology of Ahp-cyclodepsipeptides. Nat Prod Rep. 2020 Feb 26;37(2):163-174.

Bell SEJ, Charron G, Cortés E, Kneipp J, de la Chapelle ML, Langer J, Procházka M, Tran V, Schlücker S. Towards Reliable and Quantitative Surface- Enhanced Raman Scattering (SERS): From Key Parameters to Good Analytical Practice. Angew Chem Int Ed Engl. 2020 Mar 27;59(14):5454-5462.

Gigante A, Sijbesma E, Sánchez-Murcia PA, Hu X, Bier D, Bäcker S, Knauer S, Gago F, Ottmann C, Schmuck C. A Supramolecular Stabilizer of the 14-3-3ζ/ERα Protein-Protein Interaction with a Synergistic Mode of Action. Angew Chem Int Ed Engl. 2020 Mar 23;59(13):5284-5287. doi: 10.1002/anie.201914517.

Lordick F, Herrmann K. Metabolic response assessment and PET-guided treatment of esophageal cancer. Ann Oncol. 2020 Feb;31(2):163-164.

Dummer R, Brase JC, Garrett J, Campbell CD, Gasal E, Squires M, Gusenleitner D, Santinami M, Atkinson V, Mandalà M, Chiarion-Sileni V, Flaherty K, Larkin J, Robert C, Kefford R, Kirkwood JM, Hauschild A, Schadendorf D, Long GV. Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAF<sup>V600</sup>-mutant, stage III melanoma (COMBI-AD): exploratory biomarker analyses from a randomised, phase 3 trial. Lancet Oncol. 2020 Mar;21(3):358-372.

Fan X, Zerebecki S, Du R, Hübner R, Marzum G, Jiang G, Hu Y, Barcikowki S, Reichenberger S, Eychmüller A. Promoting the Electrocatalytic Performance of Noble Metal Aerogels by Ligand-Directed Modulation. Angew Chem Int Ed Engl. 2020 Mar 27;59(14):5706-5711.

Vallet C, Aschmann D, Beuck C, Killa M, Meiners A, Mertel M, Ehlers M, Bayer P, Schmuck C, Giese M, Knauer SK. Functional Disruption of the Cancer-Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole Ligand. Angew Chem Int Ed Engl. 2020 Mar 27;59(14):5567-5571.

Klatt F, Leitner A, Kim IV, Ho-Xuan H, Schneider EV, Langhammer F, Weinmann R, Müller MR, Huber R, Meister G, Kuhn CD. A precisely positioned MED12 activation helix stimulates CDK8 kinase activity. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2894-2905.

Pairault N, Zhu H, Jansen D, Huber A, Daniliuc CG, Grimme S, Niemeyer J. Heterobifunctional Rotaxanes for Asymmetric Catalysis. Angew Chem Int Ed Engl. 2020 Mar 23;59(13):5102-5107.

Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D. Cemiplimab in locally advanced cutaneous squamous cell carcinoma: results from an open-label, phase 2, single-arm trial. Lancet Oncol. 2020 Feb;21(2):294-305. .

Spassova I, Ugurel S, Terheyden P, Sucker A, Hassel JC, Ritter C, Kubat L, Habermann D, Farahpour F, Saeedghalati M, Peiffer L, Kumar R, Schrama D, Hoffmann D, Schadendorf D, Becker JC. Predominance of central memory T cells with high T-cell receptor repertoire diversity is associated with response to PD-1/PD-L1 inhibition in Merkel cell carcinoma. Clin Cancer Res. 2020 Jan 13:clincanres.2244.2019.

Merdanovic M, Burston SG, Schmitz AL, Köcher S, Knapp S, Clausen T, Kaiser M, Huber R, Ehrmann M. Activation by substoichiometric inhibition. Proc Natl Acad Sci U S A. 2020 Jan 6;201918721.

2019

Florian RT et.al. Unstable TTTTA/TTTCA expansions in MARCH6 are associated with Familial Adult Myoclonic Epilepsy type 3. Nat Commun. 2019 Oct 29;10(1):4919.

Hellerschmied D, Lehner A, Franicevic N, Arnese R, Johnson C, Vogel A, Meinhart A, Kurzbauer R, Deszcz L, Gazda L, Geeves M, Clausen T. Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin. Nat Commun. 2019 Oct 21;10(1):4781.

Rubio I, Osuchowski MF, Shankar-Hari M, Skirecki T, Winkler MS, Lachmann G, La Rosée P, Monneret G, Venet F, Bauer M, Brunkhorst FM, Kox M, Cavaillon JM, Uhle F, Weigand MA, Flohé SB, Wiersinga WJ, Martin-Fernandez M, Almansa R, Martin-Loeches I, Torres A, Giamarellos-Bourboulis EJ, Girardis M, Cossarizza A, Netea MG, van der Poll T, Scherag A, Meisel C, Schefold JC, Bermejo-Martín JF. Current gaps in sepsis immunology: new opportunities for translational research. Lancet Infect Dis. 2019 Oct 17. pii: S1473-3099(19)30567-5.

Schlücker S, Bell S, Charron G, Cortés E, Kneipp J, Lamy de la Chapelle M, Langer J, Procházka M, Tran V. Towards Reliable and Quantitative SERS: from Key Parameters to Good Analytical Practice. Angew Chem Int Ed Engl. 2019 Oct 7, [Epub ahead of print].

Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Rutkowski P, Lao CD, Cowey CL, Schadendorf D, Wagstaff J, Dummer R, Ferrucci PF, Smylie M, Hogg D, Hill A, Márquez-Rodas I, Haanen J, Guidoboni M, Maio M, Schöffski P, Carlino MS, Lebbé C, McArthur G, Ascierto PA, Daniels GA, Long GV, Bastholt L, Rizzo JI, Balogh A, Moshyk A, Hodi FS, Wolchok JD. Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma. N Engl J Med. 2019 Oct 17;381(16):1535-1546.

Fuchs M, Goergen H, Kobe C, Kuhnert G, Lohri A, Greil R, Sasse S, Topp MS, Schäfer E, Hertenstein B, Soekler M, Vogelhuber M, Zijlstra JM, Keller UB, Krause SW, Wilhelm M, Maschmeyer G, Thiemer J, Dührsen U, Meissner J, Viardot A, Eich H, Baues C, Diehl V, Rosenwald A, von Tresckow B, Dietlein M, Borchmann P, Engert A. Positron Emission Tomography-Guided Treatment in Early-Stage Favorable Hodgkin Lymphoma: Final Results of the International, Randomized Phase III HD16 Trial by the German Hodgkin Study Group. J Clin Oncol. 2019 Sep 10:JCO1900964, [Epub ahead of print].

Pan D, Walstein K, Take A, Bier D, Kaiser N, Musacchio A. Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing. Nat Commun. 2019 Sep 6;10(1):4046.

Köcher S, Resch S, Kessenbrock T, Schrapp L, Ehrmann M, Kaiser M. From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins: the chemical biology of Ahp-cyclodepsipeptides. Nat Prod Rep. 2019 Aug 27,[Epub ahead of print] Review.

Mincu RI, Mahabadi AA, Michel L, Mrotzek SM, Schadendorf D, Rassaf T, Totzeck M.Cardiovascular Adverse Events Associated With BRAF and MEK Inhibitors: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019 Aug 2;2(8):e198890.

Koerver L, Papadopoulos C, Liu B, Kravic B, Rota G, Brecht L, Veenendaal T, Polajnar M, Bluemke A, Ehrmann M, Klumperman J, Jäättelä M, Behrends C, Meyer H. The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage. EMBO Rep. 2019 Oct 4;20(10):e48014.

Zhuang Y, Xu HC, Shinde PV, Warfsmann J, Vasilevska J, Sundaram B, Behnke K, Huang J, Hoell JI, Borkhardt A, Pfeffer K, Taha MS, Herebian D, Mayatepek E, Brenner D, Ahmadian MR, Keitel V, Wieczorek D, Häussinger D, Pandyra AA, Lang KS, Lang PA. Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury. Gut. 2019 Aug 13. pii: gutjnl-2019-318215.

Grüneboom A, Kling L, Christiansen S, Mill L, Maier A, Engelke K, Quick HH, Schett G, Gunzer M. Next-generation imaging of the skeletal system and its blood supply. Nat Rev Rheumatol. 2019 Sep;15(9):533-549.

Höckel M, Wolf B, Schmidt K, Mende M, Aktas B, Kimmig R, Dornhöfer N, Horn LC. Surgical resection based on ontogenetic cancer field theory for cervical cancer: mature results from a single-centre, prospective, observational, cohort study. Lancet Oncol. 2019 Sep;20(9):1316-1326.

Watson HJ, et al. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nat Genet. 2019 Aug;51(8):1207-1214.

Schleier L, Wiendl M, Heidbreder K, Binder MT, Atreya R, Rath T, Becker E, Schulz-Kuhnt A, Stahl A, Schulze LL, Ullrich K, Merz SF, Bornemann L, Gunzer M, Watson AJM, Neufert C, Atreya I, Neurath MF, Zundler S. Non-classical monocyte homing to the gut via α4β7 integrin mediates macrophage-dependent intestinal wound healing. Gut. 2019 May 15. pii: gutjnl-2018-316772.

Merz SF, Korste S, Bornemann L, Michel L, Stock P, Squire A, Soun C, Engel DR, Detzer J, Lörchner H, Hermann DM, Kamler M, Klode J, Hendgen-Cotta UB, Rassaf T, Gunzer M, Totzeck M. Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response. Nat Commun. 2019 May 24;10(1):2312.

Al-Batran SE, et al.; FLOT4-AIO Investigators. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet. 2019 May 11;393(10184):1948-1957.

Buscaill P, Chandrasekar B, Sanguankiattichai N, Kourelis J, Kaschani F, Thomas EL, Morimoto K, Kaiser M, Preston GM, Ichinose Y, van der Hoorn RAL. Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptides. Science. 2019 Apr 12;364(6436).

Schadendorf D, et al. Patient-reported outcomes in patients with resected, high-risk melanoma with BRAF(V600E) or BRAF(V600K) mutations treated with adjuvant dabrafenib plus trametinib (COMBI-AD): a randomised, placebo-controlled, phase 3 trial. Lancet Oncol. 2019 May;20(5):701-710.

Toffalori C, et al. Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation. Nat Med. 2019 Apr;25(4):603-611.

Wang K, Sybers D, Maklad HR, Lemmens L, Lewyllie C, Zhou X, Schult F, Bräsen C, Siebers B, Valegård K, Lindås AC, Peeters E. A TetR-family transcription factor regulates fatty acid metabolism in the archaeal model organism Sulfolobus acidocaldarius. Nat Commun. 2019 Apr 4;10(1):1542.

López C, et al. Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma. Nat Commun. 2019 Mar 29;10(1):1459.

Kosinski R, Mukhortava A, Pfeifer W, Candelli A, Rauch P, Saccà B. Sites of high local frustration in DNA origami. Nat Commun. 2019 Mar 5;10(1):1061.

Lang PA, Lang KS. Stand by me(mory): Chronic infection diminishes memory pool via IL-6/STAT1. J Exp Med. 2019 Feb 19. pii: jem.20190066.  [Epub ahead of print].

Karimzadeh H, Kiraithe MM, Oberhardt V, Alizei ES, Bockmann J, Zur Wiesch JS, Budeus B, Hoffmann D, Wedemeyer H, Cornberg M, Krawczyk A, Rashidi-Alavijeh J, Rodríguez-Frías F, Casillas R, Buti M, Smedile A, Alavian SM, Heinold A, Emmerich F, Panning M, Gostick E, Price DA, Timm J, Hofmann M, Raziorrouh B, Thimme R, Protzer U, Roggendorf M, Neumann-Haefelin C. Mutations in Hepatitis D Virus Allow it to Escape Detection by CD8+ T Cells and Evolve at the Population Level. Gastroenterology. 2019 Feb 12. pii: S0016-5085(19)30366-X. [Epub ahead of print].

Schadendorf D, Livingstone E, Zimmer L. Treatment in metastatic melanoma - Time to re-think. Ann Oncol. 2019 Apr 1;30(4):501-503.

Wiesweg M, Mairinger F, Reis H, Goetz M, Walter RFH, Hager T, Metzenmacher M, Eberhardt WEE, McCutcheon A, Köster J, Stuschke M, Aigner C, Darwiche K, Schmid KW, Rahmann S, Schuler M. Machine learning-based predictors for immune checkpoint inhibitor therapy of non-small cell lung cancer. Ann Oncol.2019 Apr 1;30(4):655-657.

Kurtz DM, Scherer F, Jin MC, Soo J, Craig AFM, Esfahani MS, Chabon JJ, Stehr H, Liu CL, Tibshirani R, Maeda LS, Gupta NK, Khodadoust MS, Advani RH, Newman AM, Dührsen U, Hüttmann A, Meignan M, Casasnovas O, Westin JR, Roschewski M, Wilson WH, Gaidano G, Rossi D, Diehn M, Alizadeh AA. Reply to J. Wang et al. J Clin Oncol. 2019 Mar 20;37(9):755-757..

Niemeyer J, Mentrup T, Heidasch R, Müller SA, Biswas U, Meyer R, Papadopoulou AA, Dederer V, Haug-Kröper M, Adamski V, Lüllmann-Rauch R, Bergmann M, MayerhoferA, Saftig P, Wennemuth G, Jessberger R, Fluhrer R, Lichtenthaler SF, Lemberg MK, Schröder B. The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban. EMBO Rep. 2019 Feb 7. pii: e46449. [Epub ahead of print].

Dmitrieva-Posocco O, Dzutsev A, Posocco DF, Hou V, Yuan W, Thovarai V, Mufazalov IA, Gunzer M, Shilovskiy IP, Khaitov MR, Trinchieri G, Waisman A, Grivennikov SI. Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer. Immunity. 2019 Jan 15;50(1):166-180.e7.

Mai EK, Hielscher T, Bertsch U, Schlenzka J, Salwender HJ, Munder M, Gerecke C, Dührsen U, Brossart P, Neben K, Hillengass J, Raab MS, Merz M, Baertsch MA, Jauch A, Hose D, Martin H, Lindemann HW, Blau IW, Scheid C, Weisel KC, Goldschmidt H; German-speaking Myeloma Multicenter Group (GMMG). Bortezomib-based induction therapy with high or low-dose dexamethasone in newly diagnosed, transplant-eligible multiple myeloma. Leukemia volume 33, pages258–261 (2019).

Grüneboom A, Hawwari I, Weidner D, Culemann S, Müller S, Henneberg S, Brenzel A, Merz S, Bornemann L, Zec K, Wuelling M, Kling L, Hasenberg M, Voortmann S, Lang, Baum W, Ohs A, Kraff O, Quick HH, Jäger M, Landgraeber S, Dudda M, Danuser R, Stein JV, Rohde M, Gelse K, Garbe AI, Adamczyk A, Westendorf AM, Hoffmann D, Christiansen S, Engel DR, Vortkamp A, Krönke G, Herrmann M, Kamradt T, Schett G, Hasenberg A, Gunzer M. A network of trans-cortical capillaries as mainstay for blood circulation in long bones. Nat Metab. 2019 Feb;1(2):236-250.

Siemer S, Westmeier D, Vallet C, Becker S, Voskuhl J, Ding GB, Thines E, Stauber RH, Knauer SK. Resistance to Nano-Based Antifungals Is Mediated by Biomolecule Coronas. ACS Appl Mater Interfaces. 2019 Jan 9;11(1):104-114.

2018

Grob JJ, Garbe C, Ascierto P, Larkin J, Dummer R, Schadendorf D. Adjuvant melanoma therapy with new drugs: should physicians continue to focus on metastatic disease or use it earlier in primary melanoma? Lancet Oncol. 2018 Dec;19(12):e720-e725. Review.

Juric D, Janku F, Rodón J, Burris HA, Mayer IA, Schuler M, Seggewiss-Bernhardt R, Gil-Martin M, Middleton MR, Baselga J, Bootle D, Demanse D, Blumenstein L, Schumacher K, Huang A, Quadt C, Rugo HS. Alpelisib Plus Fulvestrant in PIK3CA-Altered and PIK3CA-Wild-Type Estrogen Receptor-Positive Advanced Breast Cancer: A Phase 1b Clinical Trial. JAMA Oncol. 2018 Dec 13:e184475. 

Ackermann S, Cartolano M, Hero B, Welte A, Kahlert Y, Roderwieser A, Bartenhagen C, Walter E, Gecht J, Kerschke L, Volland R, Menon R, Heuckmann JM, Gartlgruber M, Hartlieb S, Henrich KO, Okonechnikov K, Altmüller J, Nürnberg P, Lefever S, de Wilde B, Sand F, Ikram F, Rosswog C, Fischer J, Theissen J, Hertwig F, Singhi AD, Simon T, Vogel W, Perner S, Krug B, Schmidt M, Rahmann S, Achter V, Lang U, Vokuhl C, Ortmann M, Büttner R, Eggert A, Speleman F, O'Sullivan RJ, Thomas RK, Berthold F, Vandesompele J, Schramm A, Westermann F, Schulte JH, Peifer M, Fischer M. A mechanistic classification of clinical phenotypes in neuroblastoma. Science. 2018 Dec 7;362(6419):1165-1170.

Siemer S, Hahlbrock A, Vallet C, McClements DJ, Balszuweit J, Voskuhl J, Docter D, Wessler S, Knauer SK, Westmeier D, Stauber RH. Nanosized food additives impact beneficial and pathogenic bacteria in the human gut: a simulated gastrointestinal study. npj science of food, 22 (2018) Dec 4.

Siemer S, Westmeier D, Barz M, Eckrich J, Wünsch D, Seckert C, Thyssen C, Schilling O, Hasenberg M, Pang C, Docter D, Knauer SK, Stauber RH, Strieth S. Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics. Biomaterials. 2018 Nov 21;192:551-559.

Urbonas V, Schadendorf D, Zimmer L, Danson S, Marshall E, Corrie P, Wheater M, Plummer E, Mauch C, Scudder C, Goff M, Love SB, Mohammed SB, Middleton MR. Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF Melanoma (PACMEL): a multicentre, open-label, randomised, controlled phase II trial. Ann Oncol. 2018 Nov 14. [Epub ahead of print].

Jerby-Arnon L, et al. A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. Cell. 2018 Nov 1;175(4):984-997.e24. 

Ascierto PA, Long GV, Robert C, Brady B, Dutriaux C, Di Giacomo AM, Mortier L, Hassel JC, Rutkowski P, McNeil C, Kalinka-Warzocha E, Savage KJ, Hernberg MM, Lebbé C, Charles J, Mihalcioiu C, Chiarion-Sileni V, Mauch C, Cognetti F, Ny L, Arance A, Svane IM, Schadendorf D, Gogas H, Saci A, Jiang J, Rizzo J, Atkinson V. Survival Outcomes in Patients With Previously Untreated BRAF Wild-Type Advanced Melanoma Treated With Nivolumab Therapy: Three-Year Follow-up of a Randomized Phase 3 Trial. JAMA Oncol. 2018 Oct 25. [Epub ahead of print].

Hodi FS, Chiarion-Sileni V, Gonzalez R, Grob JJ, Rutkowski P, Cowey CL, Lao CD, Schadendorf D, Wagstaff J, Dummer R, Ferrucci PF, Smylie M, Hill A, Hogg D, Marquez-Rodas I, Jiang J, Rizzo J, Larkin J, Wolchok JD. Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067): 4-year outcomes of a multicentre, randomised, phase 3 trial. Lancet Oncol. 2018 Nov;19(11):1480-1492. Epub 2018 Oct 22. Erratum in: Lancet Oncol. 2018 Dec;19(12):e668. Lancet Oncol. 2018 Nov;19(11):e581.

Urbonas V, Schadendorf D, Zimmer L, Danson S, Marshall E, Corrie P, Wheater M, Plummer E, Mauch C, Scudder C, Goff M, Love SB, Mohammed SB, Middleton MR. Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF Melanoma (PACMEL): a multicentre, open-label, randomised, controlled phase II trial. Ann Oncol. 2018 Nov 14. [Epub ahead of print].

Casanova-Acebes M, Nicolás-Ávila JA, Li JL, García-Silva S, Balachander A, Rubio-Ponce A, Weiss LA, Adrover JM, Burrows K, A-González N, Ballesteros I, Devi S, Quintana JA, Crainiciuc G, Leiva M, Gunzer M, Weber C, Nagasawa T, Soehnlein O, Merad M, Mortha A, Ng LG, Peinado H, Hidalgo A. Neutrophils instruct homeostatic and pathological states in naive tissues. J Exp Med. 2018 Nov 5;215(11):2778-2795.

Totzeck M, Mahabadi AA, Schlosser T, Rassaf T. Weightlifting unmasks high-risk coronary anomaly. Eur Heart J. 2018 Nov 13. [Epub ahead of print].

Jockenhöfer F, Schimming TT, Schaller J, Moege J, Livingstone E, Salva KA, Zimmer L, Schadendorf D, Rösch A. Sebaceous tumours: more than skin deep. Gut. 2018 Nov;67(11):1957.

Jerby-Arnon L, et al. A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. Cell. 2018 Nov 1;175(4):984-997.e24.

Weith M, Seiler J, van den Boom J, Kracht M, Hülsmann J, Primorac I, del Pino Garcia J, Kaschani F, Kaiser M, Musacchio A, Bollen M, Meyer H. Ubiquitin-independent disassembly by a p97 AAA-ATPase complex drives PP1 holoenzyme formation. Mol Cell, 2018, doi: 10.1016/j.molcel.2018.09.020.

Ascierto PA, Long GV, Robert C, Brady B, Dutriaux C, Di Giacomo AM, Mortier L, Hassel JC, Rutkowski P, McNeil C, Kalinka-Warzocha E, Savage KJ, Hernberg MM, Lebbé C, Charles J, Mihalcioiu C, Chiarion-Sileni V, Mauch C, Cognetti F, Ny L, Arance A, Svane IM, Schadendorf D, Gogas H, Saci A, Jiang J, Rizzo J, Atkinson V. Survival Outcomes in Patients With Previously Untreated BRAF Wild-Type Advanced Melanoma Treated With Nivolumab Therapy: Three-Year Follow-up of a Randomized Phase 3 Trial. JAMA Oncol. 2018 Oct 25. [Epub ahead of print].

Hauschild A, Dummer R, Schadendorf D, Santinami M, Atkinson V, Mandalà M, Chiarion-Sileni V, Larkin J, Nyakas M, Dutriaux C, Haydon A, Robert C, Mortier L, Schachter J, Lesimple T, Plummer R, Dasgupta K, Haas T, Shilkrut M, Gasal E, Kefford R, Kirkwood JM, Long GV. Longer Follow-Up Confirms Relapse-Free Survival Benefit With Adjuvant Dabrafenib Plus Trametinib in Patients With Resected BRAF V600-Mutant Stage III Melanoma. J Clin Oncol. 2018 Oct 22:JCO1801219.

Hodi FS, Chiarion-Sileni V, Gonzalez R, Grob JJ, Rutkowski P, Cowey CL, Lao CD, Schadendorf D, Wagstaff J, Dummer R, Ferrucci PF, Smylie M, Hill A, Hogg D, Marquez-Rodas I, Jiang J, Rizzo J, Larkin J, Wolchok JD. Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067): 4-year outcomes of a multicentre, randomised, phase 3 trial. Lancet Oncol. 2018 Oct 18. pii: S1470-2045(18)30700-9.

Sokolova V, Loza K, Knuschke T, Heinen-Weiler J, Jastrow H, Hasenberg M, Buer J, Westendorf AM, Gunzer M, Epple M. A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cells. Acta Biomater . 2018 Oct 15;80:352-363.

Knier B, Hiltensperger M, Sie C, Aly L, Lepennetier G, Engleitner T, Garg G, Muschaweckh A, Mitsdörffer M, Koedel U, Höchst B, Knolle P, Gunzer M, Hemmer B, Rad R, Merkler D, Korn T. Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity. Nat Immunol. 2018 Oct 29.[Epub ahead of print].

Wagener R, López C, Kleinheinz K, Bausinger J, Aukema SM, Nagel I, Toprak UH, Seufert J, Altmüller J, Thiele H, Schneider C, Kolarova J, Park J, Hübschmann D, Murga Penas EM, Drexler HG, Attarbaschi A, Hovland R, Kjeldsen E, Kneba M, Kontny U, de Leval L, Nürnberg P, Oschlies I, Oscier D, Schlegelberger B, Stilgenbauer S, Wössmann W, Schlesner M, Burkhardt B, Klapper W, Jaffe ES, Küppers R, Siebert R. IG-MYC-positive neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas. Blood. 2018 Oct 3. pii: blood-2018-03-842088.

Lang S, Bruderek K, Kaspar C, Höing B, Kanaan O, Dominas N, Hussain T, Droege F, Eyth C, Hadaschik B, Brandau S. Clinical Relevance and Suppressive Capacity of Human Myeloid-Derived Suppressor Cell Subsets. Clin Cancer Res. 2018 Oct 1;24(19):4834-4844.

Mangolini M, Götte F, Moore A, Ammon T, Oelsner M, Lutzny-Geier G, Klein-Hitpass L, Williamson JC, Lehner PJ, Dürig J, Möllmann M, Rásó-Barnett L, Hughes K, Santoro A, Méndez-Ferrer S, Oostendorp RAJ, Zimber-Strobl U, Peschel C, Hodson DJ, Schmidt-Supprian M, Ringshausen I. Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia. Nat Commun. 2018 Sep 21;9(1):3839.

Pesenti ME, Prumbaum D, Auckland P, Smith CM, Faesen AC, Petrovic A, Erent M, Maffini S, Pentakota S, Weir JR, Lin YC, Raunser S, McAinsh AD, Musacchio A. Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80. Mol Cell. 2018 Sep 20;71(6):923-939.e10.

Dührsen U, Müller S, Rekowski J, Hüttmann A. Reply to H.J.A Adams et al and C.Gisselbrecht. J Clin Oncol. 2018 Sep 17:JCO1800898.

Schadendorf D, Akkooi ACJ, Berking C, Griewank KG, Gutzmer R, Hauschild A, Stang A, Roesch A, Ugurel S. Lancet Seminar – Melanoma. The Lancet, 2018 Sep 15;392(10151):971-984. Review.

Dummer R, Ascierto PA, Gogas HJ, Arance A, Mandala M, Liszkay G, Garbe C, Schadendorf D, Krajsova I, Gutzmer R, Chiarion Sileni V, Dutriaux C, de Groot JWB, Yamazaki N, Loquai C, Moutouh-de Parseval LA, Pickard MD, Sandor V, Robert C, Flaherty KT. Overall survival in patients with BRAF-mutant melanoma receiving encorafenib plus binimetinib versus vemurafenib or encorafenib (COLUMBUS): a multicentre, open-label, randomised, phase 3 trial. Lancet Oncol. 2018 Sep 12. pii: S1470-2045(18)30497-2.

Mahabadi AA, Rassaf T. Imaging of coronary inflammation for cardiovascular risk prediction. Lancet. 2018 Aug 24. pii: S0140-6736(18)31716-1. [Epub ahead of print].

Miao et al. Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors. Nat Genet. 2018 Sep;50(9):1271-1281.

Kurtz DM, et al. Circulating Tumor DNA Measurements As Early Outcome Predictors in Diffuse Large B-Cell Lymphoma. J Clin Oncol. 2018 Aug 20:JCO2018785246.

Shen B, Tatchen J, Sanchez-Garcia E, Bettinger HF. Evolution of the Optical Gap in the Acene Series: Undecacene. Angew Chem Int Ed Engl. 2018 Aug 13;57(33):10506-10509.

Horsthemke B. A critical view on transgenerational epigenetic inheritance in humans. Nat Commun. 2018 Jul 30;9(1):2973.

Horst AK, Wegscheid C, Schaefers C, Schiller B, Neumann K, Lunemann S, Langeneckert AE, Oldhafer KJ, Weiler-Normann C, Lang KS, Singer BB, Altfeld M, Diehl L, Tiegs G. Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice.Hepatology. 2018 Jul;68(1):200-214.

Westmeier D, Solouk-Saran D, Vallet C, Siemer S, Docter D, Götz H, Männ L, Hasenberg A, Hahlbrock A, Erler K, Reinhardt C, Schilling O, Becker S, Gunzer M, Hasenberg M, Knauer SK, Stauber RH. Nanoparticle decoration impacts airborne fungal pathobiology. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7087-7092.

Khairnar V, Duhan V, Patil AM, Zhou F, Bhat H, Thoens C, Sharma P, Adomati T, Friendrich SK, Bezgovsek J, Dreesen JD, Wennemuth G, Westendorf AM, Zelinskyy G, Dittmer U, Hardt C, Timm J, Göthert JR, Lang PA, Singer BB, Lang KS. CEACAM1 promotes CD8(+) T cell responses and improves control of a chronic viral infection. Nat Commun. 2018 Jul 2;9(1):2561.

Trusch F, Loebach L, Wawra S, Durward E, Wuensch A, Iberahim NA, de Bruijn I, MacKenzie K, Willems A, Toloczko A, Diéguez-Uribeondo J, Rasmussen T, Schrader T, Bayer P, Secombes CJ, van West P. Cell entry of a host-targeting protein of oomycetes requires gp96. Nat Commun. 2018 Jun 14;9(1):2347.

Weske S, Vaidya M, Reese A, von Wnuck Lipinski K, Keul P, Bayer JK, Fischer JW, Flögel U, Nelsen J, Epple M, Scatena M, Schwedhelm E, Dörr M, Völzke H, Moritz E, Hannemann A, Rauch BH, Gräler MH, Heusch G, Levkau B. Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss. Nat Med. 2018 May;24(5):667-678.

Dummer R, Ascierto PA, Gogas HJ, Arance A, Mandala M, Liszkay G, Garbe C, Schadendorf D, Krajsova I, Gutzmer R, Chiarion-Sileni V, Dutriaux C, de Groot JWB, Yamazaki N, Loquai C, Moutouh-de Parseval LA, Pickard MD, Sandor V, Robert C, Flaherty KT. Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 2018 May;19(5):603-615.

Ter Veer E, et al. Consensus statement on mandatory measurements in pancreatic cancer trials (COMM-PACT) for systemic treatment of unresectable disease. Lancet Oncol. 2018 Mar;19(3):e151-e160. Review.

Ziemann S, van der Linde K, Lahrmann U, Acar B, Kaschani F, Colby T, Kaiser M, Ding Y, Schmelz E, Huffaker A, Holton N, Zipfel C, Doehlemann G. An apoplastic peptide activates salicylic acid signalling in maize. Nat Plants. 2018 Mar;4(3):172-180.

Maio M, Lewis K, Demidov L, Mandalà M, Bondarenko I, Ascierto PA, Herbert C, Mackiewicz A, Rutkowski P, Guminski A, Goodman GR, Simmons B, Ye C, Yan Y, Schadendorf D; BRIM8 Investigators. Adjuvant vemurafenib in resected, BRAF(V600) mutation-positive melanoma (BRIM8): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial. Lancet Oncol. 2018 Apr;19(4):510-520.

McQuade JL, et al. Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis. Lancet Oncol. 2018 Mar;19(3):310-322.

Tucci FA, Kitanovski S, Johansson P, Klein-Hitpass L, Kahraman A, Dürig J, Hoffmann D, Küppers R. Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus-infected individuals. Blood. 2018 Feb 1;131(5):546-557.

Juric D, Rodon J, Tabernero J, Janku F, Burris HA, Schellens JHM, Middleton MR, Berlin J, Schuler M, Gil-Martin M, Rugo HS, Seggewiss-Bernhardt R, Huang A, Bootle D, Demanse D, Blumenstein L, Coughlin C, Quadt C, Baselga J. Phosphatidylinositol 3-Kinase α-Selective Inhibition With Alpelisib (BYL719) in PIK3CA-Altered Solid Tumors: Results From the First-in-Human Study. J Clin Oncol. 2018 Feb 5:JCO2017727107.

Pöhler R, Krahn JH, van den Boom J, Dobrynin G, Kaschani F, Eggenweiler HM, Zenke FT, Kaiser M, Meyer H. A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1576-1580.

Ross B, Krapp S, Augustin M, Kierfersauer R, Arciniega M, Geiss-Friedlander R, Huber R. Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1437-E1445.

Schadendorf D, Jiang J, Kelleher T, Postow MA. Reply to M. Horiguchi et al. J Clin Oncol. 2018 Mar 1;36(7):721.

Tucci FA, Kitanovski S, Johansson P, Klein-Hitpass L, Kahraman A, Dürig J, Hoffmann D, Küppers R. Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus-infected individuals. Blood. 2018 Feb 1;131(5):546-557.

Pöhler R, Krahn JH, van den Boom J, Dobrynin G, Kaschani F, Eggenweiler HM,Zenke FT, Kaiser M, Meyer H. A non-competitive inhibitor of VCP/p97 and VPS4 reveals conserved allosteric circuits in type I and II AAA ATPases. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1576-1580.

van den Boom J, Meyer H. VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. Mol Cell. 2018 Jan 18;69(2):182-194. Review.

Hönes GS, Rakov H, Logan J, Liao XH, Werbenko E, Pollard AS, Præstholm SM, Siersbæk MS, Rijntjes E, Gassen J, Latteyer S, Engels K, Strucksberg KH, Kleinbongard P, Zwanziger D, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Klein-Hitpass L, Köhrle J, Armstrong DL, Grøntved L, Bassett JHD, Williams GR, Refetoff S, Führer D, Moeller LC. Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11323-E11332.

von Wnuck Lipinski K, Weske S, Keul P, Peters S, Baba HA, Heusch G, Gräler MH, Levkau B. Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis. Blood. 2017 Dec 21;130(25):2786-2798.

Sokolova V, Shi Z, Huang S, Du Y, Kopp M, Frede A, Knuschke T, Buer J, Yang D, Wu J, Westendorf AM, Epple M. Delivery of the TLR ligand poly(I:C) to liver cells in vitro and in vivo by calcium phosphate nanoparticles leads to a pronounced immunostimulation. Acta Biomater. 2017 Dec;64:401-410.

Graessl M, Koch J, Calderon A, Kamps D, Banerjee S, Mazel T, Schulze N, Jungkurth JK, Patwardhan R, Solouk D, Hampe N, Hoffmann B, Dehmelt L, Nalbant P. An excitable Rho GTPase signaling network generates dynamic subcellular contraction patterns. J Cell Biol. 2017 Dec 4;216(12):4271-4285.

Romagnani A, Vettore V, Rezzonico-Jost T, Hampe S, Rottoli E, Nadolni W, Perotti M, Meier MA, Hermanns C, Geiger S, Wennemuth G, Recordati C, Matsushita M, Muehlich S, Proietti M, Chubanov V, Gudermann T, Grassi F, Zierler S. TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut. Nat Commun. 2017 Dec 4;8(1):1917.

Gunzer M. Escaping the traps of your own hunters. Science. 2017 Dec 1;358(6367):1126-1127.

Schadendorf D et al. Efficacy and Safety Outcomes in Patients With Advanced Melanoma Who Discontinued Treatment With Nivolumab and Ipilimumab Because of Adverse Events: A Pooled Analysis of Randomized Phase II and III Trials. J Clin Oncol. 2017 Dec 1;35(34):3807-3814.

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Krzywinska E, Kantari-Mimoun C, Kerdiles Y, Sobecki M, Isagawa T, Gotthardt D, Castells M, Haubold J, Millien C, Viel T, Tavitian B, Takeda N, Fandrey J, Vivier E, Sexl V, Stockmann C. Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis. Nat Commun. 2017 Nov 17;8(1):1597.

Bier D, Mittal S, Bravo-Rodriguez K, Sowislok A, Guillory X, Briels J, Heid C, Bartel M, Wettig B, Brunsveld L, Sanchez-Garcia E, Schrader T, Ottmann C. The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J Am Chem Soc. 2017 Nov 15;139(45):16256-16263

Schmuck C, Jiang H, Hu XY, Schlesiger S, Li M, Zellermann E, Knauer S. Morphology Dependent Cell Imaging by a Self-assembled Diacetylene Peptide Amphiphile. Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14526-14530.

Hogeweg A, Sowislok A, Schrader T, Beuck C. An NMR Method To Pinpoint Supramolecular Ligand Binding to Basic Residues on Proteins. Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14758-14762.

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Long GV, Weber JS, Larkin J, Atkinson V, Grob JJ, Schadendorf D, Dummer R, Robert C, Márquez-Rodas I, McNeil C, Schmidt H, Briscoe K, Baurain JF, Hodi FS, Wolchok JD. Nivolumab for Patients With Advanced Melanoma Treated Beyond Progression: Analysis of 2 Phase 3 Clinical Trials. JAMA Oncol. 2017 Nov 1;3(11):1511-1519.

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Item F, Wueest S, Lemos V, Stein S, Lucchini FC, Denzler R, Fisser MC, Challa TD, Pirinen E, Kim Y, Hemmi S, Gulbins E, Gross A, O'Reilly LA, Stoffel M, Auwerx J, Konrad D. Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function. Nat Commun. 2017 Sep 7;8(1):480.

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UDE leitet Projekt zu Mikroorganismen

Saci, die Biofabrik

[25.02.2020] Sie sind kleine Helfer mit großer Wirkung: Mikroorganismen produzieren Lebensmittel, Medikamente, Chemikalien und vieles mehr. Die Industrie nutzt sie wie Minifabriken, um Produkte zu entwickeln, zu verbessern oder Verfahren effizienter zu machen. Mit einem besonders robusten Kleinstlebewesen, dem Saci – genauer Sulfolobus acidocaldarius –, befasst sich ein neues biotechnologisches Forschungsprojekt. Es soll helfen, Abfallprodukte wie CO2 oder Glycerin weiterzuverwerten. „HotAcidFACToRY“ wird von der UDE geleitet und erhält 2,2 Mio. Euro Fördermittel vom Bundesforschungsministerium.*
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Studie zu bösartigem Hautkrebs Gefundene Abwehrzellen ermöglichen bessere Vorhersage möglicher Therapieerfolge

[17.02.2020] Das Merkel-Cell-Carcinoma (MCC) ist eine bösartige Form des Hautkrebses, die oft einen gravierenden Verlauf nimmt. Betroffen sind in erster Linie hellhäutige ältere Menschen, die im Lebensverlauf starker UV-Strahlung ausgesetzt waren. Von der gängigen Therapie profitiert leider nur die Hälfte der Betroffenen. Wissenschaftler des Deutschen Krebskonsortiums (DKTK) an der Medizinischen Fakultät der Universität Duisburg-Essen (UDE) haben untersucht, wie besser eingeschätzt werden kann, wem eine Immuntherapie helfen könnte. Über die Ergebnisse berichtet jüngst das Fachmagazin Clinical Cancer Research*.

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Introducing ZMB People

Katharina Severin portrait preview

Katharina Severin

PhD student, Group of Michael Ehrmann

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