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Welcome to ZMB

The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.

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New targets for cancer therapies Röntgen Prize for PD Dr. Johann Matschke

Congratulations: The renowned 15,000 euro Röntgen Prize of Justus Liebig University Giessen this year goes to cell biologist PD Dr. Johann Matschke from Essen University Hospital. ZMB member and radiation researcher Johann Matschke receives the prize for his research into the radiation resistance of cancer cells. He has discovered that the defense systems of tumor cells that have become resistant to radiotherapy can be impaired in such a way that the cells are again vulnerable to reactive oxygen radicals and thus to radiation, and hopes to derive new biomarkers for radiation resistance from his findings.

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© UDE

Mike Blüggel Awarded Joachim Herz Add-on Fellowship

Congratulations to Mike Blüggel on receiving the Joachim Herz Add-on Fellowship for "Innovative Tumor Treatment Project"! His project "Sundowner", explores light-controlled protein degradation using nanobody-PHOTACs in collaboration with UDE´s Faculty of Chemistry. The goal is to combine PHOTACs with nanobodies to enable targeted degradation of the apoptosis inhibitor Survivin in tumor tissue, thereby protecting healthy tissue.
The fellowship enables research stays, conference attendance, training, science communication activities, and participation in fellowship meetings.

© TS

Congrats! Funding Award for Kathrin Thedieck

[25.10.2024] For her research into the development of new therapeutic approaches for the rare disease tuberous sclerosis, Professor Kathrin Thedieck has now received the Klüh Foundation's EUR 25,000 funding prize, which is awarded to promote innovation in science and research. Kathrin Thedieck, head of the “Metabolism, Senescence and Autophagy” department at the newly founded Research Center One Health of the University Alliance Ruhr, has been supporting the tuberous sclerosis movement in Germany for many years, and not just scientifically.

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© jannoon028/Freepik

CRC1430 Guest Speaker Series

28.01.2025
Sascha Martens, Vienna BioCenter (VBC), Max Perutz Labs, University of Vienna

18.02.2025
Hana Polasek-Sedlackova, Institute of Biophysics, Czech Academy of Sciences

28.02.2025
Helge Ewers, Institute for Chemistry and Biochemistry, Freie Universität Berlin

Seminar program

Press Releases 2024

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uni-due.de | Presse release

"Highly Cited Researchers 2024" Sieben UDE-Forschende werden häufig zitiert

[05.12.2024] Täglich sammeln Wissenschaftler:innen der UDE wichtige Erkenntnisse und veröffentlichen neue Forschungsergebnisse für ihre Disziplinen. Sieben von ihnen gehören zu den "Highly Cited Researchers 2024". Sie zählen damit zu den ein Prozent der weltweit einflussreichsten Wissenschaftler:innen. Die renommierte Liste von Clarivate würdigt Arbeiten, die weltweit besonders häufig zitiert werden und somit maßgeblichen Einfluss auf das jeweilige Fachgebiet und/ oder über alle Disziplinen hinweg haben.
ZMB Member: Prof. Dr. Alexander Probst
ZMB Member: Prof. Dr. Dirk Schadendorf

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© TUDO, RUB, UDE
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uni-due.de | Presse release

UA Ruhr 27 neue Forschungsprofessuren besetzt

[02.12.2024] Die vier Research Center sowie das College der Universitätsallianz Ruhr (UA Ruhr) bilden ein neues forschungsstarkes Zentrum in der Wissenschaftsmetropole Ruhrgebiet. Bereits 27 internationale Spitzenwissenschaftler:innen haben sich für eine Zukunft in der UA Ruhr und damit an einer der drei Partneruniversitäten, der Ruhr-Universität Bochum, der Technischen Universität Dortmund oder der Universität Duisburg-Essen, entschieden. Insgesamt werden mehr als 50 neue Forschungsprofessuren innerhalb der Center und des College geschaffen.

ZMB Member: Prof. Dr. Dana Branzei
ZMB Member: Prof. Dr. Alexander Probst

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© UDE/Jörg Strackbein
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uni-due.de | Presse release

Sonderforschungsbereich RESIST verlängert Auszeichnung für Spitzen-Wasserforschung

[25.11.2024] Ein wichtiger Erfolg für die Wasserforschung an der Universität Duisburg-Essen: Der Sonderforschungsbereich (SFB) RESIST wird von der Deutschen Forschungsgemeinschaft (DFG) um vier Jahre verlängert. Seit 2021 erforschen die Gewässerexpert:innen der Universität Duisburg-Essen, wie Flüsse auf Klimawandel, Verschmutzung und Verbau reagieren – und wie sie sich von Belastungen erholen können. In der zweiten Phase stellt die DFG nun etwa 14 Millionen Euro bereit.
ZMB Member: Prof. Dr. Alexander Probst

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uni-due.de | Presse release

Rund sechs Millionen Euro fließen in neues Graduiertenkolleg DFG fördert Forschung zur Protonentherapie an der Universitätsallianz Ruhr

[18.11.2024] In Zukunft können Nachwuchswissenschaftler:innen im Ruhrgebiet an der Schnittstelle zwischen Physik, Chemie und Medizin promovieren und das zukunftsträchtige Themenfeld der Protonentherapie erforschen: Die Deutsche Forschungsgemeinschaft (DFG) hat die Einrichtung des Graduiertenkollegs 3043 „AMTEC-PRO“ an der TU Dortmund und der Universität Duisburg-Essen beschlossen. Sie fördert das Graduiertenkolleg (GRK) ab Oktober 2025 für zunächst fünf Jahre mit insgesamt rund sechs Millionen Euro. Sprecher des Kollegs ist Prof. Kevin Kröninger von der Fakultät Physik der TU Dortmund.

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uni-due.de | Presse release

Mitochondriale DNA-Mutationen Bremse oder Antrieb der Krebsentwicklung?

[06.11.2024] Genetische Veränderungen in der DNA der Mitochondrien spielen bei vielen erblichen Krebserkrankungen eine entscheidende Rolle. Diese Veränderungen beeinflussen auch die Entstehung und das Wachstum von schwarzem Hautkrebs, haben Forschende der Universität Duisburg-Essen und der University of Texas (USA) jetzt in Laborversuchen mit einem neu entwickelten Krebsmodell zeigen können.

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© RUB/Katja Marquard
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uni-due.de | Presse release

Ministerpräsident Hendrik Wüst MdL und NRW-Wissenschaftsministerin Ina Brandes MdL eröffnen Research Center One Health Ruhr UA Ruhr-Spitzenforschung in Gesundheit, Umwelt und Gesellschaft

[04.11.2024] Die heutige Eröffnung des Research Centers One Health Ruhr durch Ministerpräsident Hendrik Wüst MdL und NRW-Wissenschaftsministerin Ina Brandes definiert neue Maßstäbe für eine interdisziplinäre und international wettbewerbsfähige Spitzenforschung in Gesundheit, Umwelt und Gesellschaft. Der Ansatz ist neuartig: Am Research Center One Health Ruhr werden die komplexen Wechselbeziehungen zwischen menschlicher Gesundheit und Umweltgesundheit erforscht. Von den geplanten 14 Forschungsprofessuren konnten bereits acht mit international herausragenden Spitzenwissenschaftler:innen an der Universität Duisburg-Essen, der Ruhr-Universität Bochum und der TU Dortmund besetzt werden. Die drei Partner der Universitätsallianz Ruhr tragen das Research Center One Health Ruhr gemeinsam als Teil der Research Alliance Ruhr.
ZMB Member:
Prof. Dr. Alexander Probst, Prof. Dr. Kathrin Thedieck

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ZMB Research Programs

Oncology

The concept of this research program is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments.

Participating researchers from biology, experimental and clinical medicine study tumors as “biological systems" and so called “neo-organs”.

A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.

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Immunology, Infectious Diseases and Transplantation

The immune system responds to various pathogens including viruses and bacteria in different ways to prevent severe disease and persistence in the host. Many pathogens, however, have developed mechanisms to evade immune defence.

The molecular and cellular interactions of pathogens with the immune system are studied within this program.

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Molecular and Chemical Cell Biology

Molecular and chemical cell biology is an interdisciplinary research program connecting molecular cell biology and genetics with chemistry and structural biology. Scientists of the participating disciplines collaborate to advance the understanding of basic molecular mechanisms of important biological processes.

The analysis of regulation and deregulation of key pathways is linking basic biology with pathophysiology.

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Latest Publications

    Journal articles

  • Pozniak, Joanna; Pedri, Dennis; Landeloos, Ewout; Van Herck, Yannick; Antoranz, Asier; Vanwynsberghe, Lukas; Nowosad, Ada; Roda, Niccolò; Makhzami, Samira; Bervoets, Greet; Maciel, Lucas Ferreira; Pulido-Vicuña, Carlos Ariel; Pollaris, Lotte; Seurinck, Ruth; Zhao, Fang; Flem-Karlsen, Karine; Damsky, William; Chen, Limin; Karagianni, Despoina; Cinque, Sonia; Kint, Sam; Vandereyken, Katy; Rombaut, Benjamin; Voet, Thierry; Vernaillen, Frank; Annaert, Wim; Lambrechts, Diether; Boecxstaens, Veerle; Saeys, Yvan; van den Oord, Joost; Bosisio, Francesca; Karras, Panagiotis; Shain, A. Hunter; Bosenberg, Marcus; Leucci, Eleonora; Paschen, Annette; Rambow, Florian; Bechter, Oliver; Marine, Jean-Christophe
    A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma
    In: Cell Vol. 187 (2024) Nr. 1, pp. 166 - 183.e25
    Online Full Text: dx.doi.org/ (Open Access)
  • Huang, Jing; Jaekel, Andreas; van den Boom, Johannes; Podlesainski, David; Elnaggar, M.; Heuer-Jungemann, A.; Kaiser, Markus; Meyer, Hemmo; Saccà, Barbara
    A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathway
    In: Nature Nanotechnology Vol. 19 (2024) Nr. 10, pp. 1521 - 1531
    Online Full Text: dx.doi.org/ (Open Access)
  • Hedtfeld, Marius; Dammers, Alicia; Koerner, Carolin; Musacchio, Andrea
    A validation strategy to assess the role of phase separation as a determinant of macromolecular localization
    In: Molecular Cell Vol. 84 (2024) Nr. 9, pp. 1783 - 1801.e7
    Online Full Text: dx.doi.org/ (Open Access)
  • Bührer, Emanuel; Kicinski, Michal; Mandala, Mario; Pe, Madeline; Long, Georgina V; Atkinson, Victoria; Blank, Christian U; Haydon, Andrew; Dalle, Stéphane; Khattak, Adnan; Carlino, Matteo S; Meshcheryakov, Andrey; Sandhu, Shahneen; Puig, Susana; Schadendorf, Dirk; Jamal, Rahima; Rutkowski, Piotr; van den Eertwegh, Alfonsus J M; Coens, Corneel; Grebennik, Dmitri; Krepler, Clemens; Robert, Caroline; Eggermont, Alexander M M
    Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : Long-term, health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial
    In: The Lancet Oncology Vol. 25 (2024) Nr. 9, pp. 1202 - 1212
    Online Full Text: dx.doi.org/
  • Roos, Andreas; Schmitt, Linda-Isabell; Hansmann, Christina; Hezel, Stefanie; Salmanian, Schahin; Hentschel, Andreas; Meyer, Nancy; Marina, Adela Della; Kölbel, Heike; Kleinschnitz, Christoph; Schara-Schmidt, Ulrike; Leo, Markus; Hagenacker, Tim
    Alteration of LARGE1 abundance in patients and a mouse model of 5q-associated spinal muscular atrophy
    In: Acta Neuropathologica Vol. 147 (2024) Nr. 1, 53
    Online Full Text: dx.doi.org/ (Open Access)
  • Felip, E.; Cho, B.C.; Gutiérrez, V.; Alip, A.; Besse, B.; Lu, S.; Spira, A.I.; Girard, N.; Califano, R.; Gadgeel, S.M.; Yang, J.C.-H.; Yamamoto, S.; Azuma, K.; Kim, Y.J.; Lee, K.-H.; Danchaivijitr, P.; Ferreira, C.G.; Cheng, Y.; Sendur, M.A.N.; Chang, G.-C.; Wang, C.-C.; Prabhash, K.; Shinno, Y.; Stroyakovskiy, D.; Paz-Ares, L.; Rodriguez-Cid, J.R.; Martin, C.; Campelo, M.R.G.; Hayashi, H.; Nguyen, D.; Tomasini, P.; Gottfried, M.; Dooms, C.; Passaro, A.; Schuler, Martin; Gelatti, A.C.Z.; Owen, S.; Perdrizet, K.; Ou, S.-H.I.; Curtin, J.C.; Zhang, J.; Gormley, M.; Sun, T.; Panchal, A.; Ennis, M.; Fennema, E.; Daksh, M.; Sethi, S.; Bauml, J.M.; Lee, S.-H.
    Amivantamab plus lazertinib versus osimertinib in first-line EGFR-mutant advanced non-small-cell lung cancer with biomarkers of high-risk disease : a secondary analysis from MARIPOSA
    In: Annals of Oncology Vol. 35 (2024) Nr. 9, pp. 805 - 816
    Online Full Text: dx.doi.org/ (Open Access)
  • Massoni-Badosa, Ramon; Aguilar-Fernández, Sergio; Nieto, Juan C.; Soler-Vila, Paula; Elosua-Bayes, Marc; Marchese, Domenica; Kulis, Marta; Vilas-Zornoza, Amaia; Bühler, Marco Matteo; Rashmi, Sonal; Alsinet, Clara; Caratù, Ginevra; Moutinho, Catia; Ruiz, Sara; Lorden, Patricia; Lunazzi, Giulia; Colomer, Dolors; Frigola, Gerard; Blevins, Will; Romero-Rivero, Lucia; Jiménez-Martínez, Víctor; Vidal, Anna; Mateos-Jaimez, Judith; Maiques-Diaz, Alba; Ovejero, Sara; Moreaux, Jérôme; Palomino, Sara; Gomez-Cabrero, David; Agirre, Xabier; Weniger, Marc A.; King, Hamish W.; Garner, Lucy C.; Marini, Federico; Cervera-Paz, Francisco Javier; Baptista, Peter M.; Vilaseca, Isabel; Rosales, Cecilia; Ruiz-Gaspà, Silvia; Talks, Benjamin; Sidhpura, Keval; Pascual-Reguant, Anna; Hauser, Anja E.; Haniffa, Muzlifah; Prosper, Felipe; Küppers, Ralf; Gut, Ivo Glynne; Campo, Elias; Martin-Subero, José Ignacio; Heyn, Holger
    An atlas of cells in the human tonsil
    In: Immunity Vol. 57 (2024) Nr. 2, pp. 379 - 399.e18
    Online Full Text: dx.doi.org/ (Open Access)
  • Teuber, A.; Schulz, T.; Fletcher, B.S.; Gontla, R.; Mühlenberg, Thomas; Zischinsky, M.-L.; Niggenaber, J.; Weisner, J.; Kleinbölting, S.B.; Lategahn, J.; Sievers, S.; Müller, M.P.; Bauer, Sebastian; Rauh, D.
    Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA
    In: Nature Communications Vol. 15 (2024) Nr. 1, 63
    Online Full Text: dx.doi.org/ (Open Access)
  • Prosdocimi, Elena; Carpanese, Veronica; Todesca, Luca Matteo; Varanita, Tatiana; Bachmann, Magdalena; Festa, Margherita; Bonesso, Daniele; Perez-Verdaguer, Mireia; Carrer, Andrea; Velle, Angelo; Peruzzo, Roberta; Muccioli, Silvia; Doni, Davide; Leanza, Luigi; Costantini, Paola; Stein, Frank; Rettel, Mandy; Felipe, Antonio; Edwards, Michael J.; Gulbins, Erich; Cendron, Laura; Romualdi, Chiara; Checchetto, Vanessa; Szabo, Ildiko
    BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway
    In: Science Advances Vol. 10 (2024) Nr. 36, eadn9361
    Online Full Text: dx.doi.org/ (Open Access)
  • Anker, Markus S.; Rassaf, Tienush; Zamorano, José L.; Khan, Muhammad Shahzeb; Landmesser, Ulf
    Cardiac wasting and cancer
    In: European Heart Journal Vol. 45 (2024) Nr. 34, pp. 3135 - 3137
    Online Full Text: dx.doi.org/ (Open Access)
  • Lu, I-Na; Cheung, Phyllis Fung-Yi; Heming, Michael; Thomas, Christian; Giglio, Giovanni; Leo, Markus; Erdemir, Merve; Wirth, Timo; König, Simone; Dambietz, Christine A.; Schroeter, Christina B.; Nelke, Christopher; Siveke, Jens; Ruck, Tobias; Klotz, Luisa; Haider, Carmen; Höftberger, Romana; Kleinschnitz, Christoph; Wiendl, Heinz; Hagenacker, Tim; Meyer zu Horste, Gerd
    Cell-mediated cytotoxicity within CSF and brain parenchyma in spinal muscular atrophy unaltered by nusinersen treatment
    In: Nature Communications Vol. 15 (2024) Nr. 1, 4120
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Heinrich, Michael C.; Zhang, Xinhua; Jones, Robin L.; George, Suzanne; Serrano, César; Deng, Yanhong; Bauer, Sebastian; Cai, Shirong; Wu, Xin; Zhou, Yongjian; Tao, Kaixiong; Zheng, Zhichao; Zhang, Jun; Cui, Yuehong; Cao, Hui; Wang, Meining; Hu, Jin; Yang, Jason; Li, Jian; Shen, Lin
    Clinical Benefit of Avapritinib in KIT-Mutant Gastrointestinal Stromal Tumors : A Post Hoc Analysis of the Phase I NAVIGATOR and Phase I/II CS3007-001 Studies
    In: Clinical Cancer Research Vol. 30 (2024) Nr. 4, pp. 719 - 728
    Online Full Text: dx.doi.org/
  • Dobersalske, Celia; Rauschenbach, Laurèl; Hua, Yichao; Berliner, Christoph; Steinbach, Anita; Grüneboom, Anika; Kokkaliaris, Konstantinos D.; Heiland, Dieter H.; Berger, Pia; Langer, Sarah; Tan, Chin L.; Stenzel, Martin; Landolsi, Somaya; Weber, Flora; Darkwah Oppong, Marvin; Werner, Rudolf A.; Gull, Hanah; Schröder, Thomas; Linsenmann, Thomas; Buck, Andreas K.; Gunzer, Matthias; Stuschke, Martin; Keyvani, Kathy; Forsting, Michael; Glas, Martin; Kipnis, Jonathan; Steindler, Dennis A.; Reinhardt, Hans Christian; Green, Edward W.; Platten, Michael; Tasdogan, Alpaslan; Herrmann, Ken; Rambow, Florian; Cima, Igor; Sure, Ulrich; Scheffler, Björn
    Cranioencephalic functional lymphoid units in glioblastoma
    In: Nature Medicine (2024) in press
    Online Full Text: dx.doi.org/ (Open Access)
  • Tran, Diem H.; Kim, Dohun; Kesavan, Rushendhiran; Brown, Harrison; Dey, Trishna; Soflaee, Mona Hoseini; Vu, Hieu S.; Tasdogan, Alpaslan; Guo, Jason; Bezwada, Divya; Al Saad, Houssam; Cai, Feng; Solmonson, Ashley; Rion, Halie; Chabatya, Rawand; Merchant, Salma; Manales, Nathan J.; Tcheuyap, Vanina T.; Mulkey, Megan; Mathews, Thomas P.; Brugarolas, James; Morrison, Sean J.; Zhu, Hao; DeBerardinis, Ralph J.; Hoxhaj, Gerta
    De novo and salvage purine synthesis pathways across tissues and tumors
    In: Cell Vol. 187 (2024) Nr. 14, pp. 3602 - 3618.e20
    Online Full Text: dx.doi.org/
  • Arrieta-Bolaños, Esteban; van der Burg, Lars L. J.; Gedde-Dahl, Tobias; Robin, Marie; Salmenniemi, Urpu; Kröger, Nicolaus; Yakoub-Agha, Ibrahim; Huynh, Anne; Crawley, Charles; Deconinck, Eric; Bulabois, Claude Eric; Forcade, Edouard; Tholouli, Eleni; van der Hem, Joost G. K.; van Balen, Peter; Hoogenboom, Jorinde D.; de Wreede, Liesbeth C.; Malard, Florent; Ruggeri, Annalisa; Fleischhauer, Katharina
    Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDS
    In: Blood Vol. 144 (2024) Nr. 16, pp. 1747 - 1751
    Online Full Text: dx.doi.org/
  • Heger, Jan-Michel; Mattlener, Julia; Schneider, Jessica; Gödel, Philipp; Sieg, Noëlle; Ullrich, Fabian; Lewis, Richard; Bucaciuc-Mracica, Teodora; Schwarz, Roland F.; Rueß, Daniel; Ruge, Maximilian I.; Montesinos-Rongen, Manuel; Deckert, Martina; Blau, Tobias; Kutsch, Nadine; Balke-Want, Hyatt; Weiss, Jonathan; Becker, Kerstin; Reinhardt, H. Christian; Hallek, Michael; Borchmann, Peter; von Tresckow, Bastian; Borchmann, Sven
    Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA
    In: Blood Vol. 143 (2024) Nr. 6, pp. 522 - 534
    Online Full Text: dx.doi.org/
  • George, Julie; Maas, Lukas; Abedpour, Nima; Cartolano, Maria; Kaiser, Laura; Fischer, Rieke N.; Scheel, Andreas H.; Weber, Jan-Philipp; Hellmich, Martin; Bosco, Graziella; Volz, Caroline; Mueller, Christian; Dahmen, Ilona; John, Felix; Alves, Cleidson Padua; Werr, Lisa; Panse, Jens Peter; Kirschner, Martin; Engel-Riedel, Walburga; Jürgens, Jessica; Stoelben, Erich; Brockmann, Michael; Grau, Stefan; Sebastian, Martin; Stratmann, Jan A.; Kern, Jens; Hummel, Horst-Dieter; Hegedüs, Balazs; Schuler, Martin; Plönes, Till; Aigner, Clemens; Elter, Thomas; Toepelt, Karin; Ko, Yon-Dschun; Kurz, Sylke; Grohé, Christian; Serke, Monika; Höpker, Katja; Hagmeyer, Lars; Doerr, Fabian; Hekmath, Khosro; Strapatsas, Judith; Kambartel, Karl-Otto; Chakupurakal, Geothy; Busch, Annette; Bauernfeind, Franz-Georg; Griesinger, Frank; Luers, Anne; Dirks, Wiebke; Wiewrodt, Rainer; Luecke, Andrea; Rodermann, Ernst; Diel, Andreas; Hagen, Volker; Severin, Kai; Ullrich, Roland T.; Reinhardt, Hans Christian; Quaas, Alexander; Bogus, Magdalena; Courts, Cornelius; Nürnberg, Peter; Becker, Kerstin; Achter, Viktor; Büttner, Reinhard; Wolf, Jürgen; Peifer, Martin; Thomas, Roman K.
    Evolutionary trajectories of small cell lung cancer under therapy
    In: Nature Vol. 627 (2024) Nr. 8005, pp. 880 - 889
    Online Full Text: dx.doi.org/ (Open Access)
  • Long, Georgina V.; Hauschild, Axel; Santinami, Mario; Kirkwood, John M.; Atkinson, Victoria; Mandala, Mario; Merelli, Barbara; Sileni, Vanna Chiarion; Nyakas, Marta; Haydon, Andrew; Dutriaux, Caroline; Robert, Caroline; Mortier, Laurent; Schachter, Jacob; Schadendorf, Dirk; Lesimple, Thierry; Plummer, Ruth; Larkin, James; Tan, Monique; Adnaik, Sachin Bajirao; Burgess, Paul; Jandoo, Tarveen; Dummer, Reinhard
    Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma
    In: The New England Journal of Medicine (2024) in press
    Online Full Text: dx.doi.org/
  • Giuranna, Johanna; Zheng, Yiran; Brandt, Matthäus; Jall, Sigrid; Mukherjee, Amrita; Shankhwar, Soni; Renner, Simone; Kurapati, Nirup Kumar; May, Caroline; Peters, Triinu; Herpertz-Dahlmann, Beate; Seitz, Jochen; de Zwaan, Martina; Herzog, Wolfgang; Ehrlich, Stefan; Zipfel, Stephan; Giel, Katrin; Egberts, Karin; Burghardt, Roland; Föcker, Manuel; Marcus, Katrin; Keyvani, Kathy; Müller, Timo D.; Schmitz, Frank; Rajcsanyi, Luisa Sophie; Hinney, Anke
    Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation
    In: Molecular Psychiatry (2024) in press
    Online Full Text: dx.doi.org/ (Open Access)
  • Schrader, Thomas; Kubik, Stefan; Braun, Manfred
    Günter Wulff (1935 –2023) : Father of Molecular Imprinting
    In: Angewandte Chemie International Edition Vol. 63 (2024) Nr. 12, e202402244
    Online Full Text: dx.doi.org/ (Open Access)
  • Schwarz, Tatjana; Ptok, Johannes; Damagnez, Maximilian; Menne, Christopher; Alizei, Elahe Salimi; Lang-Meli, Julia; Maas, Michelle; Habermann, Daniel; Hoffmann, Daniel; Schulze zur Wiesch, Julian; Lauer, Georg; Kefalakes, Helenie; Cornberg, Markus; Kraft, Anke RM.; Gliga, Smaranda; Bock, Hans H.; Horn, Peter A.; Maini, Mala K.; Thimme, Robert; Wedemeyer, Heiner; Nattermann, Jacob; Heinemann, Falko M.; Luedde, Tom; Neumann-Haefelin, Christoph; Walker, Andreas; Timm, Jörg
    HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replication
    In: Journal of Hepatology (2024) in press
    Online Full Text: dx.doi.org/ (Open Access)
  • Schmiedtchen, Marco; Maisuls, Iván; Siera, Hannah; Balszuweit, Jan; Wölper, Christoph; Giese, Michael R. A.; Haberhauer, Gebhard; Strassert, Cristian A.; Voskuhl, Jens
    In situ Cyclization of Aromatic Thioethers in Emissive Materials to Generate Phosphorescent Dibenzothiophenes
    In: Angewandte Chemie International Edition (2024) in press
    Online Full Text: dx.doi.org/ (Open Access)
  • Gahlot, Pinki; Kravic, Bojana; Rota, Giulia; van den Boom, Johannes; Levantovsky, Sophie; Schulze, Nina; Maspero, Elena; Polo, Simona; Behrends, Christian; Meyer, Hemmo
    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
    In: Molecular Cell (2024) pp. 1556 - 1569.e10
    Online Full Text: dx.doi.org/ (Open Access)
  • Pleuger, Richard; Cozma, Christian; Hohoff, Simone; Denkhaus, Christian; Dudziak, Alexander; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Vetter, Ingrid R.; Westermann, Stefan
    Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor
    In: Current Biology Vol. 34 (2024) Nr. 11, pp. 2279 - 2293.e6
    Online Full Text: dx.doi.org/ (Open Access)
  • Schmidt, Mirko; Grethe, Christian; Recknagel, Sarah; Kipka, Gian-Marvin; Klink, Nikolas; Gersch, Malte
    N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1
    In: Angewandte Chemie International Edition Vol. 63 (2024) Nr. 12, e202318849
    Online Full Text: dx.doi.org/ (Open Access)
  • Schuler, Martin; Cuppens, Kristof; Plönes, Till; Wiesweg, Marcel; Du Pont, Bert; Hegedus, Balazs; Köster, Johannes; Mairinger, Fabian; Darwiche, Kaid; Paschen, Annette; Maes, Brigitte; Vanbockrijck, Michel; Lähnemann, David; Zhao, Fang; Hautzel, Hubertus; Theegarten, Dirk; Hartemink, Koen; Reis, Henning; Baas, Paul; Schramm, Alexander; Aigner, Clemens
    Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer : A randomized phase 2 trial
    In: Nature Medicine Vol. 30 (2024) Nr. 6, pp. 1602 - 1611
    Online Full Text: dx.doi.org/ (Open Access)
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