Welcome to ZMB

Welcome to ZMB

The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.

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News & Events

© ZMB/ICCE

New CRC Funding Approved

We are happy to announce that our proposal has been approved by the DFG on Tuesday, May 25th, 2021, and the work in our Collaborative Research Centre "Molecular Mechanisms of Cell State Transitions" can start now.

CRC 1430
© pixabay

Save the date Auf zu neuen Kooperationen

Seminar zum Austausch der Disziplinen

***
NEUER TERMIN
26.01.2022
14:30 – 16 Uhr
***

Interessierte SprecherInnen können sich gerne bei Dr. Maike Müller melden.

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© DGBM

Save the date 20202 Anual Meeting

of the
German Society for Biomaterials (DGBM)
- save the dates -
21. - 24. September 2022

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© G.Buechel

Erfolgreich in der Krebsforschung MedBio Absolventin zur Juniorprofessorin berufen

[29.06.2021] Wir freuen uns über den besonderen Erfolg unserer Absolventin des Masterstudiengangs Medizinische Biologie: Gabriele Büchel wurde im Mai 2021 von der Julius-Maximilians-Universität Würzburg zur Juniorprofessorin berufen, wo sie am Lehrstuhl für Biochemie und Molekularbiologie eine eigene Arbeitsgruppe leitet.

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Press Releases 2020/2021

© MZ UK Essen/Martin Kaiser

DFG fördert Forschung zur Sepsis Irrwege des Immunsystems verhindern

[13.09.2021] „Blutvergiftung“ nennt sie der Volksmund, die Medizin spricht von Sepsis: Schwere Verläufe führen oft zu lebensbedrohlichem Organversagen und zusätzlichen Infektionen mit multi-resistenten Erregern. Prof. Dr. Stefanie Flohé von der Medizinischen Fakultät der UDE erforscht seit Jahren, warum einige Menschen dafür empfänglicher sind als andere. In einem neuen Projekt untersucht ihr Team mit Forschenden des Universitätsklinikums Düsseldorf, wie Immunstörungen bei Sepsis entstehen – und wie sie verhindert werden könnten. Die Deutsche Forschungsgemeinschaft (DFG) fördert das Projekt für drei Jahre mit 450.000 Euro.

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© UDE/AK Epple

Schlaganfallforschung ohne Tierversuche „Mini-brains“ statt Mausmodell

[19.07.2021] Erforscht man Schäden durch Schlaganfälle, kommt man nicht um sie herum: Mäuse. An ihren Hirnen werden Gefäßverschlüsse und deren Folgen simuliert – bis jetzt: Die Zukunft könnte „mini-brains“ aus dem Labor gehören. Mit ihnen will ein Forscherteam aus der Medizin und der Chemie der UDE neue Methoden in der Schlaganfallforschung ohne Tierversuche etablieren. Das Bundesforschungsministerium (BMBF) fördert das kürzlich gestartete Projekt mit 750.000 Euro.

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© pixabay

Internationale Genomanalyse COVID-19-Risikofaktoren enthüllt

[09.07.2021] Rauchen und Übergewicht können zu einem schwereren Corona-Krankheitsverlauf führen: Das ist ein Teilergebnis einer internationalen Studie, an der auch Forschende der Medizinischen Fakultät der UDE und des Universitätsklinikums Essen beteiligt sind. Doch es wurden auch mehrere genetische Marker entdeckt, die mit der SARS-CoV-2-Infektion und dem Schweregrad von COVID-19 in Verbindung stehen. Die Ergebnisse wurden im renommierten Fachmagazin „Nature“ veröffentlicht.

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© private

"One Health – from Molecules to Systems" UA Ruhr Kooperation für internationale Spitzenforschung

[08.07.2021] Der Ausbau der internationalen Spitzenforschung der Universitätsallianz Ruhr (UA Ruhr) kann starten: Am 7. Juli 2021 unterzeichneten die Rektoren der Ruhr-Universität Bochum, der Technischen Universität Dortmund und der Universität Duisburg-Essen im Beisein von Wissenschaftsministerin Isabel Pfeiffer-Poensgen einen Kooperationsvertrag zur Gründung der Research Alliance Ruhr. Damit können die vier Research Center und das College nun beginnen, internationale Spitzenwissenschaftlerinnen und -wissenschaftler für ihre zukunftsweisenden Forschungsvorhaben zu gewinnen. Für die Aufbauphase stellt die Landesregierung hierfür bis 2024 aus Mitteln der Ruhr-Konferenz bis zu 75 Millionen Euro zur Verfügung.

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© ZMB/ ICCE

Neuer SFB an der UDE Molekulare Mechanismen der Zellvermehrung entschlüsseln

[25.05.2021] Damit sich ein Organismus entwickeln und regenerieren kann, müssen sich Zellen vermehren. Während der Vermehrung werden nacheinander mehrere genau definierte Zustände durchlaufen, deren Übergänge strikt reguliert werden. Die hierfür zentralen molekularen Mechanismen untersucht jetzt ein neuer Sonderforschungsbereich (SFB), den die Deutsche Forschungsgemeinschaft (DFG) an der Universität Duisburg-Essen (UDE) eingerichtet hat. Dafür stehen in den nächsten vier Jahren rund 10 Millionen Euro zur Verfügung.

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© UDE/Frank Preuß

Neu am ZMB: Katharina Lückerath Tumore überlisten

[31.03.2021] Nur wer Tumore im Detail versteht, kann sie optimal behandeln. Dr. Katharina Lückerath vom UK Essen erforscht, wie ihre biologischen Prozesse ablaufen. Die neue Professorin für Präklinische Nuklearmedizinische Theranostik entwickelt an der Medizinischen Fakultät der UDE neue Ansätze für Radionuklidtherapien und bildgebende Verfahren.

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© UDE/Sánchez-García

Success of Interdisciplinary Collaboration Switching Off the Survival Protein for Cancer Cells

[8.03.2021] It is called the "survival protein" because it plays a central role in the growth of cancer cells: survivin influences two important processes in the body's cells at the same time – cell death and cell division. Chemists and biologists at the UDE have now succeeded in developing a precise molecule that can bind the protein’s surface at a defined site and switch it off. "Nature Communications" covers the topic.

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© HUST

Cooperation UDE / Wuhan One of the most important publications on COVID-19

[18.01.2021] One of the world's most important publications on COVID-19 was written in cooperation with the medical faculty and scientific partners in Wuhan (China). It was published in April 2020 and describes important changes in the immune system of those affected. Eight months later, the relevance of the study becomes apparent: It is one of the most cited publications on the subject worldwide.

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ZMB Research Programs

Oncology

The concept of this research program is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments.

Participating researchers from biology, experimental and clinical medicine study tumors as “biological systems" and so called “neo-organs”.

A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.

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Immunology, Infectious Diseases and Transplantation

The immune system responds to various pathogens including viruses and bacteria in different ways to prevent severe disease and persistence in the host. Many pathogens, however, have developed mechanisms to evade immune defence.

The molecular and cellular interactions of pathogens with the immune system are studied within this program.

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Molecular and Chemical Cell Biology

Molecular and chemical cell biology is an interdisciplinary research program connecting molecular cell biology and genetics with chemistry and structural biology. Scientists of the participating disciplines collaborate to advance the understanding of basic molecular mechanisms of important biological processes.

The analysis of regulation and deregulation of key pathways is linking basic biology with pathophysiology.

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Latest Publications

    Journal articles

  • Rankin-Turner, Stephanie; Vader, Pieter; O'Driscoll, Lorraine; Giebel, Bernd; Heaney, Liam M.; Davies, Owen G.
    A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos
    In: Advanced Drug Delivery Reviews Vol. 173 (2021) pp. 479 - 491
    ISSN: 1872-8294; 0169-409X
  • Kohlhaas, Vivien; Blakemore, Stuart James; Al-Maarri, Mona; Nickel, Nadine; Pal, Martin; Roth, Andreas; Hövelmeyer, Nadine; Schäfer, Stephan C.; Knittel, Gero; Lohneis, Philipp; Nikolic, Milos; Wiederstein, Janica L.; Franitza, Marek; Georgomonolis, Theodoros; Reinart, Nina; Herling, Marco; Herling, Carmen; Hartmann, Elena M.; Rosenwald, Andreas; Klapper, Wolfram; Büttner, Reinhard; Moia, Riccardo; Rossi, Davide; Boldorini, Renzo; Gaidano, Gianluca; Frenzel, Lukas P.; Reinhardt, Christian; Brüning, Jens C.; Hallek, Michael; Krüger, Marcus; Peifer, Martin; Pallasch, Christian P.; Wunderlich, F. Thomas
    Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1
    In: Blood Vol. 137 (2021) Nr. 5, pp. 646 - 660
    ISSN: 1528-0020; 0006-4971
  • Reimann, Maurice; Schrezenmeier, Jens; Richter-Pechanska, Paulina; Dolnik, Anna; Hick, Timon Pablo; Schleich, Kolja; Cai, Xiurong; Fan, Dorothy N. Y.; Lohneis, Philipp; Maßwig, Sven; Denker, Sophy; Busse, Antonia; Knittel, Gero; Flümann, Ruth; Childs, Dorothee; Childs, Liam; Gätjens-Sanchez, Ana-Maria; Bullinger, Lars; Rosenwald, Andreas; Reinhardt, Christian; Schmitt, Clemens A.
    Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas
    In: Blood Vol. 137 (2021) Nr. 20, pp. 2785 - 2799
    ISSN: 1528-0020; 0006-4971
  • Bottomley, Andrew; Coens, Corneel; Mierzynska, Justyna; Blank, Christian U; Mandalà, Mario; Long, Georgina V; Atkinson, Victoria G; Dalle, Stéphane; Haydon, Andrew M; Meshcheryakov, Andrey; Khattak, Adnan; Carlino, Matteo S; Sandhu, Shahneen; Puig, Susana; Ascierto, Paolo A; Larkin, James; Lorigan, Paul C; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Di Giacomo, Anna Maria; van den Eertwegh, Alfonsus J M; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; van Akkooi, Alexander C J; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Kicinski, Michal; Suciu, Stefan; Robert, Caroline; Eggermont, Alexander M M; Lesimple, Thierry; Maio, Michele; Linette, Gerald; Mortier, Laurent; Svane, Inge Marie; Schachter, Jacob; Brown, Michael; Hersey, Peter; Barrow, Catherine; Kudchadkar, Ragini; Dutriaux, Caroline; Song, Xinni; Quaglino, Pietro; Queirolo, Paola; Meier, Friedegund; Stroyakovskiy, Daniil; Guillot, Bernard; Romero, Pablo Luis Ortiz; Bastholt, Lars; Garbe, Claus; Grange, Florent; Mohr, Peter; Algazi, Alain; Bechter, Oliver; Hernberg, Micaela; Loquai, Carmen; Meiss, Frank; Chiarion Sileni, Vanna; Bar-Sela, Gil; Fitzharris, Bernard; Saiag, Philippe; Arnault, Jean-Philippe; Simon, Jan-Christoph; Stephens, Rosalie; Baurain, Jean-Francois; Lebbe, Célèste; Combemale, Patrick; Dummer, Reinhard; Hauschild, Axel; Parente, Phillip; Yamazaki, Naoya; Milhem, Mohammed; Leccia, Marie-Thérèse; Geoffrois, Lionel; Kretschmer, Lutz; Dunwoodie, Elaine; Walker, John; Lotem, Michal; Hendler, Daniel; Mackiewicz, Andrzej; Sekulovic, Lidija; Dzienis, Marcin; Hospers, Geke A.P.; Siano, Marco; Hassel, Jessica; Corrie, Philippa; Passos, Maria-Jose; Levin, Max; Hoeller, Christoph; Machet, Laurent; Hallmeyer, Sigrun; Waterston, Ashita; Descamps, Vincent; Kiecker, Felix; Aarts, Maureen; Schmidt, Henrik; Raimundo, Ana; Nyakas, Marta; Lacour, Jean-Philippe; Berking, Carola; Ferrucci, Pier Francesco; Jameson, Michael; Kim, Kevin; Yokota, Kenji; Kerger, Joseph; Aubin, François; Groenewegen, Gerard; Kapiteijn, Helena; Boehncke, Wolf-Henning; Utikal, Jochen; Casasola, Richard; Marshall, Ernest; Ferraresi, Virginia; Richtig, Erika; Matkovic, Suzana; Inozume, Takashi; Crook, Timothy; McNeil, Catriona; Kiyohara, Yoshio; Avril, Marie-Francoise; Hein, Rüdiger; Terheyden, Patrick; Nathan, Paul; Aoi, Jun; Skytta, Tanja; Jouary, Thomas; Takenouchi, Tatsuya; Straume, Oddbjorn; Martins, César; Mukhametshina, Guzel
    Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial
    In: The Lancet Oncology Vol. 22 (2021) Nr. 5, pp. 655 - 664
    ISSN: 1474-5488; 1470-2045
  • Eggermont, Alexander M M; Blank, Christian U; Mandalà, Mario; Long, Georgina V; Atkinson, Victoria G; Dalle, Stéphane; Haydon, Andrew M; Meshcheryakov, Andrey; Khattak, Adnan; Carlino, Matteo S; Sandhu, Shahneen; Larkin, James; Puig, Susana; Ascierto, Paolo A; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Di Giacomo, Anna Maria; van den Eertwegh, Alfonsus J M; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; Lorigan, Paul C; van Akkooi, Alexander C J; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Kicinski, Michal; Suciu, Stefan; Robert, Caroline; Menzies, Alex; Lesimple, Thierry; Maio, Michele; Linette, Gerald; Brown, Michael; Hersey, Peter; Svane, Inge Marie; Mortier, Laurent; Schachter, Jacob; Barrow, Catherine; Kudchadkar, Ragini; Song, Xinni; Dutriaux, Caroline; Quaglino, Pietro; Meier, Friedegund; Queirolo, Paola; Stroyakovskiy, Daniil; Bastholt, Lars; Guillot, Bernard; Garbe, Claus; Ortiz Romero, Pablo Luis; Grange, Florent; Mohr, Peter; Algazi, Alain; Bechter, Oliver; Hernberg, Micaela; Arnault, Jean-Philippe; Saiag, Philippe; Loquai, Carmen; Meiss, Frank; Simon, Jan-Christoph; Bar-Sela, Gil; Chiarion Sileni, Vanna; Fitzharris, Bernard; McCrystal, Mike; Parente, Phillip; Baurain, Jean-Francois; Combemale, Patrick; Lebbe, Célèste; Hauschild, Axel; Yamazaki, Naoya; Dummer, Reinhard; Milhem, Mohammed; Dzienis, Marcin; Walker, John; Geoffrois, Lionel; Leccia, Marie-Thérèse; Kretschmer, Lutz; Hendler, Daniel; Lotem, Michal; Mackiewicz, Andrzej; Sekulovic, Lidija; Dunwoodie, Elaine; Hoeller, Christoph; Machet, Laurent; Hassel, Jessica; Hospers, Geke A.P.; Passos, Maria-Jose; Levin, Max; Fehr, Martin; Corrie, Philippa; Waterston, Ashita; Hallmeyer, Sigrun; Schmidt, Henrik; Descamps, Vincent; Lacour, Jean-Philippe; Berking, Carola; Kiecker, Felix; Ferrucci, Pier Francesco; Yokota, Kenji; Aarts, Maureen; Jameson, Michael; Winge-Main, Anna Katharina; Ferreira, Paula; Kim, Kevin; McNeil, Catriona; Hofmann-Wellenhof, Reiner; Kerger, Joseph; Aubin, François; Utikal, Jochen; Ferraresi, Virginia; Inozume, Takashi; Kiyohara, Yoshio; Groenewegen, Gerard; Kapiteijn, Helena; Matkovic, Suzana; Boehncke, Wolf-Henning; Casasola, Richard; Crook, Timothy; Marshall, Ernest; Skytta, Tanja; Avril, Marie-Francoise; Jouary, Thomas; Hein, Rüdiger; Terheyden, Patrick; Aoi, Jun; Takenouchi, Tatsuya; Straume, Oddbjorn; Martins, César; Mukhametshina, Guzel; Nathan, Paul
    Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trial
    In: The Lancet Oncology Vol. 22 (2021) Nr. 5, pp. 643 - 654
    ISSN: 1474-5488; 1470-2045
  • Abel, Frederik; Giebel, Bernd; Frey, Ulrich H.
    Agony of choice : How anesthetics affect the composition and function of extracellular vesicles
    In: Advanced Drug Delivery Reviews Vol. 175 (2021)
    ISSN: 1872-8294; 0169-409X
  • Wettstein, Lukas; Weil, Tatjana; Conzelmann, Carina; Müller, Janis A.; Groß, Rüdiger; Hirschenberger, Maximilian; Seidel, Alina; Klute, Susanne; Zech, Fabian; Prelli Bozzo, Caterina; Preising, Nico; Fois, Giorgio; Lochbaum, Robin; Knaff, Philip Maximilian; Mailänder, Volker; Ständker, Ludger; Thal, Dietmar Rudolf; Schumann, Christian; Stenger, Steffen; Kleger, Alexander; Lochnit, Günter; Mayer, Benjamin; Ruiz-Blanco, Yasser B.; Hoffmann, Markus; Sparrer, Konstantin M. J.; Pöhlmann, Stefan; Sanchez-Garcia, Elsa; Kirchhoff, Frank; Frick, Manfred; Münch, Jan
    Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1726
    ISSN: 2041-1723
  • Chuang, Chen-Hua; Dorsch, Madeleine; Dujardin, Philip; Silas, Sukrit; Ueffing, Kristina; Hölken, Johanna M; Yang, Dian; Winslow, Monte M.; Grüner, Barbara M.
    Altered mitochondria functionality defines a metastatic cell state in lung cancer and creates an exploitable vulnerability
    In: Cancer Research Vol. 81 (2021) Nr. 3, pp. 567 - 579
    ISSN: 0008-5472; 1538-7445
  • Henneberg, Sophie; Hasenberg, Anja; Maurer, Andreas; Neumann, Franziska; Bornemann, Lea; Gonzalez-Menendez, Irene; Kraus, Andreas; Hasenberg, Mike; Thornton, Christopher R.; Pichler, Bernd J.; Gunzer, Matthias; Beziere, Nicolas
    Antibody-guided in vivo imaging of Aspergillus fumigatus lung infections during antifungal azole treatment
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1707
    ISSN: 2041-1723
  • Walstein, Kai; Petrovic, Arsen; Pan, Dongqing; Hagemeier, Birte; Vogt, Dorothee; Vetter, Ingrid R.; Musacchio, Andrea
    Assembly principles and stoichiometry of a complete human kinetochore module
    In: Science Advances Vol. 7 (2021) Nr. 27,
    ISSN: 2375-2548
  • Singh, Priyanka; Pesenti, Marion E.; Maffini, Stefano; Carmignani, Sara; Hedtfeld, Marius; Petrovic, Arsen; Srinivasamani, Anupallavi; Bange, Tanja; Musacchio, Andrea
    BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis
    In: Molecular Cell Vol. 81 (2021) Nr. 1, pp. 67 - 87.e9
    ISSN: 1097-4164; 1097-2765
  • van Sorge, Nina M.; Bonsor, Daniel A.; Deng, Liwen; Lindahl, Erik; Schmitt, Verena; Lyndin, Mykola; Schmidt, Alexej; Nilsson, Olof R.; Brizuela, Jaime; Boero, Elena; Sundberg, Eric J.; van Strijp, Jos A. G.; Doran, Kelly S.; Singer, Bernhard B.; Lindahl, Gunnar; McCarthy, Alex J.
    Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors
    In: The EMBO Journal Vol. 40 (2021) Nr. 7, pp. e106103
    ISSN: 1460-2075; 0261-4189
  • Piano, Valentina; Alex, Amal; Stege, Patricia; Maffini, Stefano; Stoppiello, Gerardo A.; Huis In'T Veld, Pim J.; Vetter, Ingrid R.; Musacchio, Andrea
    CDC20 assists its catalytic incorporation in the mitotic checkpoint complex
    In: Science Vol. 371 (2021) Nr. 6524, pp. 67 - 71
    ISSN: 1095-9203; 0036-8075
  • Syeda, Mahrukh M.; Wiggins, Jennifer M.; Corless, Broderick C; Long, Georgina V.; Flaherty, Keith T.; Schadendorf, Dirk; Nathan, Paul D.; Robert, Caroline; Ribas, Antoni; Davies, Michael A.; Grob, Jean Jacques; Gasal, Eduard; Squires, Matthew; Marker, Mahtab; Garrett, James; Brase, Jan C.; Polsky, David
    Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib : A clinical validation study
    In: The Lancet Oncology Vol. 22 (2021) Nr. 3, pp. 370 - 380
    ISSN: 1470-2045; 1474-5488
  • Wey, Karolin; Schirrmann, Ronja; Diesing, Detlef; Lang, Stephan; Brandau, Sven; Hansen, Stefan; Epple, Matthias
    Coating of cochlear implant electrodes with bioactive DNA-loaded calcium phosphate nanoparticles for the local transfection of stimulatory proteins
    In: Biomaterials Vol. 276 (2021)
    ISSN: 1878-5905; 0142-9612
  • Schuler, Martin
    Corrigendum to “Inhibiting fibroblast growth factor receptors in cancer – The next generation”
    In: Annals of Oncology Vol. 32 (2021) Nr. 1, pp. 126
    ISSN: 1569-8041; 0923-7534
  • Bebber, Christina M.; Thomas, Emily S.; Stroh, Jenny; Chen, Zhiyi; Androulidaki, Ariadne; Schmitt, Anna; Höhne, Michaela N.; Stüker, Lukas; de Pádua Alves, Cleidson; Khonsari, Armin; Dammert, Marcel A.; Parmaksiz, Fatma; Tumbrink, Hannah L.; Beleggia, Filippo; Sos, Martin L.; Riemer, Jan; George, Julie; Brodesser, Susanne; Thomas, Roman K.; Reinhardt, Christian; von Karstedt, Silvia
    Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 2048
    ISSN: 2041-1723
  • Chen, Jieliang; Li, Yaming; Lai, Fritz; Wang, Yang; Sutter, Kathrin; Dittmer, Ulf; Ye, Jianyu; Zai, Wenjing; Liu, Min; Shen, Fang; Wu, Min; Hu, Kongying; Li, Baocun; Lu, Mengji; Zhang, Xiaonan; Zhang, Jiming; Li, Jianhua; Chen, Qingfeng; Yuan, Zhenghong
    Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ Signaling
    In: Hepatology Vol. 73 (2021) Nr. 2, pp. 486 - 502
    ISSN: 1527-3350; 0270-9139
  • Adamczyk, Alexandra; Pastille, Eva; Kehrmann, Jan; Vu, Vivian P.; Geffers, Robert; Wasmer, Marie-Hélène; Kasper, Stefan; Schuler, Martin; Lange, Christian; Muggli, Beat; Rau, Tilman T.; Klein, Diana; Hansen, Wiebke; Krebs, Philippe; Buer, Jan; Westendorf, Astrid
    GPR15 facilitates recruitment of regulatory T cells to promote colorectal cancer
    In: Cancer Research Vol. 81 (2021) Nr. 11, pp. 2970 - 2982
    ISSN: 1538-7445; 0008-5472
  • Barella, Mariano; Violi, Ianina L.; Gargiulo, Julian; Martinez, Luciana P.; Goschin, Florian; Guglielmotti, Victoria; Pallarola, Diego; Schlücker, Sebastian; Pilo-Pais, Mauricio; Acuna, Guillermo P.; Maier, Stefan A.; Cortes, Emiliano; Stefani, Fernando D.
    In situ photothermal response of single gold nanoparticles through hyperspectral imaging anti-stokes thermometry
    In: ACS Nano Vol. 15 (2021) Nr. 2, pp. 2458 - 2467
    ISSN: 1936-0851; 1936-086X
  • Bénard, Alan; Jacobsen, Anne; Brunner, Maximilian; Krautz, Christian; Klösch, Bettina; Swierzy, Izabela; Naschberger, Elisabeth; Podolska, Malgorzata J.; Kouhestani, Dina; David, Paul; Birkholz, Torsten; Castellanos, Ixchel; Trufa, Denis; Sirbu, Horia; Vetter, Marcel; Kremer, Andreas E.; Hildner, Kai; Hecker, Andreas; Edinger, Fabian; Tenbusch, Matthias; Mühl-Zürbes, Petra; Steinkasserer, Alexander; Richter, Enrico; Streeck, Hendrik; Berger, Marc M.; Brenner, Thorsten; Weigand, Markus A.; Swirski, Filip K.; Schett, Georg; Grützmann, Robert; Weber, Georg F.
    Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1112
    ISSN: 2041-1723
  • Peña-Llopis, Samuel
    Leadership challenges defused
    In: Science Vol. 371 (2021) Nr. 6533, pp. 1070
    ISSN: 1095-9203; 0036-8075
  • Weniger, Marc; Küppers, Ralf
    Molecular biology of Hodgkin lymphoma
    In: Leukemia Vol. 35 (2021) Nr. 4, pp. 968 - 981
    ISSN: 1476-5551; 0887-6924
  • Frangieh, Chris J.; Melms, Johannes C.; Thakore, Pratiksha I.; Geiger-Schuller, Kathryn R.; Ho, Patricia; Luoma, Adrienne M.; Cleary, Brian; Jerby-Arnon, Livnat; Malu, Shruti; Cuoco, Michael S.; Zhao, Maryann; Ager, Casey R.; Rogava, Meri; Hovey, Lila; Rotem, Asaf; Bernatchez, Chantale; Wucherpfennig, Kai W.; Johnson, Bruce E.; Rozenblatt-Rosen, Orit; Schadendorf, Dirk; Regev, Aviv; Izar, Benjamin
    Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion
    In: Nature Genetics Vol. 53 (2021) Nr. 3, pp. 332 - 341
    ISSN: 1061-4036; 1546-1718
  • Hübschmann, Daniel; Kleinheinz, Kortine; Wagener, Rabea; Bernhart, Stephan H.; López, Cristina; Toprak, Umut H.; Sungalee, Stephanie; Ishaque, Naveed; Kretzmer, Helene; Kreuz, Markus; Waszak, Sebastian M.; Paramasivam, Nagarajan; Ammerpohl, Ole; Aukema, Sietse M.; Beekman, Renée; Bergmann, Anke K.; Bieg, Matthias; Binder, Hans; Borkhardt, Arndt; Borst, Christoph; Brors, Benedikt; Bruns, Philipp; Carrillo de Santa Pau, Enrique; Claviez, Alexander; Doose, Gero; Haake, Andrea; Karsch, Dennis; Haas, Siegfried; Hansmann, Martin-Leo; Hoell, Jessica I.; Hovestadt, Volker; Huang, Bingding; Hummel, Michael; Jäger-Schmidt, Christina; Kerssemakers, Jules N. A.; Korbel, Jan O.; Kube, Dieter; Lawerenz, Chris; Lenze, Dido; Martens, Joost H. A.; Ott, German; Radlwimmer, Bernhard; Reisinger, Eva; Richter, Julia; Rico, Daniel; Rosenstiel, Philip; Rosenwald, Andreas; Schillhabel, Markus; Stilgenbauer, Stephan; Stadler, Peter F.; Martín-Subero, José I.; Szczepanowski, Monika; Warsow, Gregor; Weniger, Marc; Zapatka, Marc; Valencia, Alfonso; Stunnenberg, Hendrik G.; Lichter, Peter; Möller, Peter; Loeffler, Markus; Eils, Roland; Klapper, Wolfram; Hoffmann, Steve; Trümper, Lorenz; Küppers, Ralf; Schlesner, Matthias; Siebert, Reiner
    Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas
    In: Leukemia Vol. 35 (2021) pp. 2002 - 2016
    ISSN: 0887-6924; 1476-5551
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    Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19 : Current evidence and potential mechanisms
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    Single-Particle Hyperspectral Imaging Reveals Kinetics of Silver Ion Leaching from Alloy Nanoparticles
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    Sotorasib for Lung Cancers with KRAS p.G12C Mutation
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