Welcome to ZMB
Welcome to ZMB
The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.
News & Events

1st International CRC1430 Symposium „Triggers of cell state transitions“
Save the date for the upcoming
1st International CRC 1430 Symposium:
„Triggers of cell state transitions“ from
October 10 - 12, 2023.
Location: Glaspavillon, University Duisburg-Essen, Campus Essen

Upcoming
Annual Meeting of the German-Ukrainian Academic Society
together with
Ukraine Days in North Rhine-Westphalia
September 28 - 29, 2023.
Venue: University of Duisburg-Essen
Chemistry Building S07, Lecture Hall S07 S00 D07.
Meeting Organizer: Prof. Dr. Matthias Epple, Inorganic Chemistry, University of Duisburg-Essen

CRC1430 Speaker Series
26.09.2023
Elmar Wolf, Julius-Maximilians-University, Würzburg
07.11.2023
Gertrudis Rojas, Center of Molecular Immunology, Havana
5.15pm, S05V01E69
30.01.2024
Patrizia Agostinis, KU Leuven
5.15pm, S05V01E69
For further information please contact crc1430@uni-due.de

DKTK project funded by German Cancer Aid
[20.07.2023] Congratulations to our members Samuel Peña-Llopis and Silvia Vega-Rubín-de-Celis! The German Cancer Aid has granted 1.3 million euros to support their project on “Innovative therapies for BAP1 mutant neoplasms”. In collaboration with the German Cancer Research Center (DKFZ) and the Technical University of Munich, the project will investigate new therapeutic options to target mutations in the BAP1 tumor suppressor gene, often mutated in very aggressive types of cancer. Led by Dr. Samuel Peña-Llopis, the team will target pathways associated with BAP1 mutations using cell lines, mouse models, and patient-derived tumor organoids.
Press Releases 2023

Neues Superresolution-Mikroskop Zellen entschlüsseln
[18.09.2023] Hochauflösende Bilder von Zellen aufnehmen und dadurch dynamische Prozesse im Nanometerbereich verfolgen – das ist am Imaging Center Campus Essen (ICCE) des Zentrums für Medizinische Biotechnologie (ZMB) nun möglich. Hier wird derzeit ein neues hochmodernes Superresolution-Mikroskop für Lebendzellanalysen installiert. Das Ziel der Forschenden der UDE: wichtige Zellprozesse mit sehr hoher räumlicher und zeitlicher Präzision entschlüsseln und damit bedeutende Fortschritte in der biologischen und medizinischen Forschung erzielen – etwa bei der Entstehung und Therapierbarkeit von Krebs.

Neu an UDE/UK Essen: Bernd Giebel Heilende Zell-Kommunikation
[12.09.2023] Das Leben von Organismen beruht auf dem unentwegten Informationsaustausch ihrer Zellen. Wesentlich beteiligt sind extrazelluläre Vesikel. Von den richtigen Zellen abgegeben, lassen sie sich therapeutisch nutzen. Wie groß das Potenzial dieser kleinen Informationsträger ist, untersucht etwa Dr. Bernd Giebel, neuer Professor für Translationale extrazelluläre Vesikel-Forschung an der Medizinischen Fakultät der UDE.

Bundesklimaschutzministerium fördert UDE-Projekt Katalysatoren an Textilien
[06.09.2023] Ohne Katalysatoren läuft in der chemischen Industrie kaum etwas. Wie ihr Einsatz optimiert werden könnte, untersuchen die Fakultät für Chemie der UDE und das Deutsche Textilforschungszentrum Nord-West (DTNW) im Projekt „OrgKatTex“. Das Bundesministerium für Wirtschaft und Klimaschutz fördert das Projekt mit 501.000 Euro; die UDE erhält davon 229.000 Euro.

Zehn Jahre Westdeutsches Zentrum für Infektiologie Dem Erreger auf der Spur
[03.08.2023] Infektionserkrankungen erforschen, diagnostizieren, therapieren und auch präventiv vorbeugen – mit diesem Ziel eröffnete im Sommer 2013 das Westdeutsche Zentrum für Infektiologie (WZI) am Universitätsklinikum Essen. Seither koordiniert es die klinische Arbeit und Forschung der Infektionsmedizin vor Ort. Am 31. August wird nun sein zehnjähriges Bestehen gefeiert.

Veröffentlichung in „Nature Cancer“ Fortschritt in der Krebstherapie
[01.08.2023] Neue Erkenntnis in der Melanomforschung: Ob eine Immuncheckpoint-Therapie wirkt, entscheidet das Zytokin Interleukin-17. Immun Checkpoint-Inhibitoren (ICI) sind hochwirksame Medikamente in der modernen Krebstherapie. Ihr Einsatz hat auch bei Melanompatient:innen die Überlebenschancen verbessert. Aber nicht alle Erkrankten profitieren gleichermaßen. Ein Team von Forschenden der Medizinischen Fakultät der UDE und Deutschem Konsortium für Translationale Krebsforschung (DKTK) hat nun einen Faktor gefunden, der das Ansprechen auf die ICI-Therapie maßgeblich beeinflusst. Die Ergebnisse wurden kürzlich in „Nature Cancer“ veröffentlicht.

Wasserforschung: Mikroorganismen wehren sich gegen Parasiten Neue mögliche Funktion der Genschere entdeckt
[28.07.2023] Mit der Genschere bekämpfen Mikroorganismen virale Angreifer. In der Gentechnik wird das mikrobielle Immunsystem zur gezielten Veränderung des Erbguts eingesetzt. Unter Leitung von Professor Dr. Alexander Probst, Mikrobiologe am Research Center One Health Ruhr der Research Alliance Ruhr, hat ein Forschungsteam nun eine weitere Funktion der spezialisierten Genomsequenz entdeckt: Archaeen – Mikroorganismen, die den Bakterien oft optisch sehr ähnlich sind – setzen sie auch ein, um Parasiten zu bekämpfen. Die Ergebnisse hat das Team nun in Nature Microbiology veröffentlicht.

2nd Henriette Herz Scout at UDE Chemist seeks Talents
[13.07.2023] When molecules are not directly connected – but nevertheless inseparable: Interlocked molecules behave like chain links or a ring on a rod which is closed on both sides. Prof. Dr Jochen Niemeyer at the UDE-Faculty of Chemistry is researching how they are applied. As a scout in the Henriette Herz Programme of the Alexander von Humboldt Foundation, he is now looking for international scientific support.

Second UDE research magazine published Focus: Health
[07.07.2023] Good killer cells, migraines and the power of our own expectations: health, man's greatest asset, is the central topic of the new UDE research magazine. Look through the microscope of microbiology, learn about one of the longest studies in the world and dive into the depths of the earth.

AURORA Master Class Bühne frei für Doktorand:innen
[06.06.2023] Eine Bühne, ein Thema, eine Folie und drei Minuten Zeit – das ist das Prinzip des Three Minute Thesis (3MT)-Contests, an dem nun acht AURORA-Partnerhochschulen in Island teilnehmen. Auch drei Doktorand:innen der UDE sind dabei. Der Wettbewerb bildet den Abschluss einer Master Class zum Thema Wissenschaftskommunikation, die vom 5. bis 8. Juni stattfindet.

SFB wird verlängert Bessere Therapie gegen Bronchialkarzinom
[05.06.2023] Der Kampf gegen die aggressivste Form von Lungenkrebs kann fortgestzt werden: Für vier weitere Jahre fördert die Deutsche Forschungsgemeinschaft (DFG) die Wissenschaftler:innen des Sonderforschungsbereiches 1399 (SFB), unter ihnen auch Expert:innen der Medizinischen Faklutät der UDE. Sie entwickeln neue Ansätze für bessere Therapien gegen das kleinzellige Bronchialkarzinom.
Research Magazine UDE
Focus: Health
Good Killer Cells
Chemotherapy, radiotherapy or surgery – these are the three common forms of cancer therapy. The lymphoma specialists at University Hospital Essen are investigating the possibility of a different approach.
Research Magazine UDE
Focus: Health
Please treat unequally
Height: just under 1.80 meters; weight: approximately 85 kilograms. One X and one Y chromosome. This has been more or less accepted as the norm in medical research – until now. Prof. Dr Anke Hinney is about to change that.
Research Magazine UDE
Focus: Health
One Health
What happens deep down in Earth’s subsurface? That’s the focus of Alexander Probst’s research. He also studies how microorganisms influence environmental health. The research professor at the new Research Center One Health Ruhr has declared war on antibiotic resistances.
ZMB Research Programs
Oncology
The concept of this research program is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments.
Participating researchers from biology, experimental and clinical medicine study tumors as “biological systems" and so called “neo-organs”.
A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.
Immunology, Infectious Diseases and Transplantation
The immune system responds to various pathogens including viruses and bacteria in different ways to prevent severe disease and persistence in the host. Many pathogens, however, have developed mechanisms to evade immune defence.
The molecular and cellular interactions of pathogens with the immune system are studied within this program.
Molecular and Chemical Cell Biology
Molecular and chemical cell biology is an interdisciplinary research program connecting molecular cell biology and genetics with chemistry and structural biology. Scientists of the participating disciplines collaborate to advance the understanding of basic molecular mechanisms of important biological processes.
The analysis of regulation and deregulation of key pathways is linking basic biology with pathophysiology.
Latest Publications
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A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in GlioblastomaIn: Clinical Cancer Research Vol. 29 (2023) Nr. 2, pp. 488 - 500ISSN: 1557-3265; 1078-0432Online Full Text: dx.doi.org/ (Open Access)
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Active Remodeling of Capillary Endothelium via Cancer Cell-Derived MMP9 Promotes Metastatic Brain ColonizationIn: Cancer Research Vol. 83 (2023) Nr. 8, pp. 1299 - 1314ISSN: 1538-7445; 0008-5472Online Full Text: dx.doi.org/
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Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma : An international collaborative analysisIn: Leukemia Vol. 37 (2023) Nr. 7, pp. 1511 - 1520ISSN: 1476-5551; 0887-6924Online Full Text: dx.doi.org/ (Open Access)
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Author Correction: Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesisIn: Nature Communications Vol. 14 (2023) Nr. 1, pp. 2675ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access)
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Author Correction: Pan-cancer analysis of whole genomesIn: Nature Vol. 614 (2023) Nr. 7948, pp. E39ISSN: 0028-0836; 1476-4687Online Full Text: dx.doi.org/ (Open Access)
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Chirality control of a single carbene molecule by tip-induced van der Waals interactionsIn: Nature Communications Vol. 14 (2023) Nr. 1,ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access)
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Circulating tumor DNA analysis of the phase III VOYAGER trial : KIT mutational landscape and outcomes in patients with advanced gastrointestinal stromal tumor treated with avapritinib or regorafenibIn: Annals of Oncology Vol. 34 (2023) Nr. 7, pp. 615 - 625ISSN: 1569-8041; 0923-7534Online Full Text: dx.doi.org/
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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survivalIn: Cell Vol. 186 (2023) Nr. 10, pp. 2176 - 2192.e22ISSN: 0092-8674; 1097-4172Online Full Text: dx.doi.org/ (Open Access)
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Correction : The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid NeoplasmsIn: Leukemia (2023)ISSN: 1476-5551; 0887-6924Online Full Text: dx.doi.org/ (Open Access)
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Decrypting drug actions and protein modifications by dose- and time-resolved proteomicsIn: Science Vol. 380 (2023) Nr. 6640, pp. 93 - 101ISSN: 1095-9203; 0036-8075Online Full Text: dx.doi.org/
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Differentiating between Acidic and Basic Surface Hydroxyls on Metal Oxides by Fluoride Substitution : A Case Study on Blue TiO₂ from Laser Defect EngineeringIn: Angewandte Chemie International Edition Vol. 62 (2023) Nr. 12,ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/ (Open Access)
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Erdafitinib in patients with advanced solid tumours with FGFR alterations (RAGNAR) : an international, single-arm, phase 2 studyIn: The Lancet Oncology Vol. 24 (2023) Nr. 8, pp. 925 - 935ISSN: 1474-5488; 1470-2045Online Full Text: dx.doi.org/
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HLA class II loss and JAK1/2 deficiency coevolve in melanoma leading to CD4 T cell and IFNγ cross-resistanceIn: Clinical Cancer Research Vol. 29 (2023) Nr. 15, pp. 2894 - 2907ISSN: 1557-3265; 1078-0432Online Full Text: dx.doi.org/
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Hemizygous CDKN2A deletion confers worse survival outcomes in IDHmut-noncodel gliomasIn: Neuro-Oncology Vol. 25 (2023) Nr. 9, pp. 1721 - 1723ISSN: 1522-8517; 1523-5866Online Full Text: dx.doi.org/ (Open Access)
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Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesisIn: Nature Communications Vol. 14 (2023) Nr. 1,ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access)
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Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s diseaseIn: Nature Communications Vol. 14 (2023) Nr. 1,ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access)
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Impact of TP53 on outcome of patients with myelofibrosis undergoing hematopoietic stem cell transplantationIn: Blood Vol. 141 (2023) Nr. 23, pp. 2901 - 2911ISSN: 1528-0020; 0006-4971Online Full Text: dx.doi.org/
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Impact of bimetallic interface design on heat generation in plasmonic Au/Pd nanostructures studied by single-particle thermometryIn: Nature Communications Vol. 14 (2023) Nr. 1,ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access)
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Importance of broken geometric symmetry of single-atom Pt sites for efficient electrocatalysisIn: Nature Communications Vol. 14 (2023) Nr. 1,ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access)
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Individual glioblastoma cells harbor both proliferative and invasive capabilities during tumor progressionIn: Neuro-Oncology (2023) in pressISSN: 1522-8517; 1523-5866Online Full Text: dx.doi.org/
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Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancerIn: Gut (2023) in pressISSN: 1468-3288; 0017-5749Online Full Text: dx.doi.org/
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LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer GrowthIn: Clinical Cancer Research Vol. 29 (2023) Nr. 6, pp. 1137 - 1154ISSN: 1557-3265; 1078-0432Online Full Text: dx.doi.org/
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Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancerIn: Nature Vol. 615 (2023) Nr. 7950, pp. 168 - 174ISSN: 0028-0836; 1476-4687Online Full Text: dx.doi.org/ (Open Access)
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Molecular heterogeneity and commonalities in pancreatic cancer precursors with gastric and intestinal phenotypeIn: Gut Vol. 72 (2023) Nr. 3, pp. 522 - 534ISSN: 1468-3288; 0017-5749Online Full Text: dx.doi.org/ (Open Access)
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Neoadjuvant immunotherapy for melanoma is now ready for clinical practiceIn: Nature Medicine Vol. 29 (2023) Nr. 6, pp. 1310 - 1312ISSN: 1546-170X; 1078-8956Online Full Text: dx.doi.org/
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Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial TherapyIn: Cancer Research Vol. 83 (2023) Nr. 8, pp. 1315 - 1328ISSN: 1538-7445; 0008-5472Online Full Text: dx.doi.org/ (Open Access)
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Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identificationIn: Nature Communications Vol. 14 (2023) Nr. 1, pp. 4632ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access)
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Resting natural killer cell homeostasis relies on tryptophan/NAD⁺ metabolism and HIF-1αIn: EMBO Reports (2023)ISSN: 1469-3178; 1469-221XOnline Full Text: dx.doi.org/ (Open Access)
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Sotorasib in KRAS p.G12C-Mutated Advanced Pancreatic CancerIn: The New England Journal of Medicine Vol. 388 (2023) Nr. 1, pp. 33 - 43ISSN: 1533-4406; 0028-4793Online Full Text: dx.doi.org/
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Sotorasib versus docetaxel for previously treated non-small-cell lung cancer with KRASG¹²C mutation : a randomised, open-label, phase 3 trialIn: Lancet Vol. 401 (2023) Nr. 10378, pp. 733 - 746ISSN: 1474-547X; 0140-6736; 0023-7507Online Full Text: dx.doi.org/
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Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infectionIn: Science Advances Vol. 9 (2023) Nr. 27,ISSN: 2375-2548Online Full Text: dx.doi.org/ (Open Access)
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Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophyIn: Acta Neuropathologica Vol. 145 (2023) Nr. 5, pp. 611 - 635ISSN: 0001-6322; 1432-0533Online Full Text: dx.doi.org/ (Open Access)
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Stable kinetochore-microtubule attachment requires loop-dependent Ndc80-Ndc80 bindingIn: The EMBO Journal Vol. 42 (2023) Nr. 13,ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/ (Open Access)
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Structural basis of ubiquitin-independent PP1 complex disassembly by p97In: The EMBO Journal Vol. 42 (2023) Nr. 14,ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/ (Open Access)
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The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunityIn: Cancer Cell Vol. 41 (2023) Nr. 7, pp. 1207 - 1221.e12ISSN: 1535-6108; 1878-3686Online Full Text: dx.doi.org/
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The German Network for Personalized Medicine to enhance patient care and translational researchIn: Nature Medicine Vol. 29 (2023) Nr. 6, pp. 1298 - 1301ISSN: 1546-170X; 1078-8956Online Full Text: dx.doi.org/
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The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPaseIn: Nature Communications Vol. 14 (2023) Nr. 1,ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access)
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The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint ComplexIn: Nature Communications Vol. 14 (2023) Nr. 1,ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access)
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The transcriptional and regulatory identity of erythropoietin producing cellsIn: Nature Medicine Vol. 29 (2023) Nr. 5, pp. 1191 - 1200ISSN: 1546-170X; 1078-8956Online Full Text: dx.doi.org/
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Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responsesIn: Immunity Vol. 56 (2023) Nr. 6, pp. 1341 - 1358.e11ISSN: 1097-4180; 1074-7613Online Full Text: dx.doi.org/ (Open Access)
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Tuning the Electronic Properties of Platinum in Hybrid-Nanoparticle Assemblies for use in Hydrogen Evolution ReactionIn: Angewandte Chemie International Edition Vol. 62 (2023) Nr. 25,ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/ (Open Access)