Welcome to ZMB
Welcome to ZMB
The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.
News & Events

Coronavirus: Current Information
(University of Duisburg-Essen)

21.12.2020 Tumor researcher honored
Dr. Johann Matschke, young scientist at the Institute of Cell Biology (Tumor Research) was awarded the Dieter-Frankenberg-Nachwuchspreis of the German Society for Biological Radiation Research. He received the award, endowed with 2,000 euros, for his outstanding work on the elucidation of metabolic adaptation reactions with relevance for radiation resistance and potential for its therapeutic modulation.

13.10.2020 PD Dr. Adalbert Krawczyk awarded
ZMB member virologist PD Dr. Adalbert Krawczyk has been awarded the Gottschalk-Diederich-Baedeker Prize 2020. This honors his outstanding achievements at the University Hospital Essen for research into the development of a highly effective antibody for the prevention and therapy of Herpex Simplex Virus (HSV) infections.

New Heisenberg Professorship Interlocked molecules as catalysts
[02.12.2020] Not directly connected, but inseparable: Interlocked molecules are interwoven like links in a chain or like a ring on a thread. Dr. Jochen Niemeyer investigates how they are applied. The new Heisenberg professor for organic and supramolecular chemistry is particularly interested in their use as catalysts.
Press Releases 2020/2021

Cooperation UDE / Wuhan One of the most important publications on COVID-19
[18.01.2021] One of the world's most important publications on COVID-19 was written in cooperation with the medical faculty and scientific partners in Wuhan (China). It was published in April 2020 and describes important changes in the immune system of those affected. Eight months later, the relevance of the study becomes apparent: It is one of the most cited publications on the subject worldwide.

Nationwide Network University Medicine Funding for COVID-19 research in Essen approved
[08.01.2021] Clinics and institutes of the University Hospital Essen that collect and analyze disease data and samples from COVID-19 patients are supported by the German Federal Ministry of Education and Research (BMBF) with 895,000€ until the end of this year. The joint goal of the researchers and clinicians is to formulate new research questions and answer existing ones.

DFG funds immune cell study Covid-19: Better understanding of defense cells
[21.12.2020] In a study, researchers from the Faculty of Medicine are investigating the role played by certain immune cells in the fight against SARS-CoV-2 and why some of them last longer than others. Their findings could become particularly important for the treatment and vaccination of the population against COVID-19. The German Research Foundation (DFG) is funding the project for one year with 38,000 euros through a COVID-19 emergency program.

Treatment of blood disorders Immune mechanism discovered
[03.12.2020] Researchers from the Medical Faculty of the UDE and the German Consortium for Translational Cancer Research (DKTK) at the partner location Essen/Düsseldorf have been able to explain a new mechanism in the human immune system. On the basis of their results, new approaches can be studied to improve the therapeutic success of blood stem cell transplants. The German-Dutch study was published in the renowned journal Blood.

SARS-CoV-2 UV light inactivates corona viruses
[01.09.2020] SARS-CoV-2 viruses can be completely inactivated with ultraviolet light. This was shown of Virologyby a promising study by ZMB member PD Dr. Adalbert Krawczyk (photo) and Dr. Christiane Heilingloh from the Institute at the University Hospital Essen. The American Journal of Infection Control is now reporting on this. Their research was funded by the University Medicine Essen Foundation and the Rudolf Ackermann Foundation.

DFG Research Grant for Virkramjeet Singh Feedback loops between gut microbes and immune cells may impact outcome after stroke
[10.06.2020] The DFG approved funding for an exciting new research project of Dr. Vikramjeet Singh that targets at exploring how the interaction with gut microbiota shapes the impact of neutrophils on ischemic brain injury. Singh is principal investigator at the Institute of Experimental Immunology and Imaging at the University Hospital Essen. Working as postdoc at the Institute for Stroke and Dementia Research at the LMU Medical Center, Singh and his colleagues identified a bidirectional communication along the brain–gut microbiota–immune axis and could show that the gut microbiota is a potentially central regulator of immune homeostasis.

Erkenntnisse für Test und Impfstoffe Neue Details der Immunantwort bei Covid-19
[22.05.2020] Das menschliche Immunsystem reagiert auf mehr als nur das bisher fokussierte Virusprotein. Das ist bedeutend für Tests und mögliche Impfstoffe. Forschungsteams der Ruhr-Universität Bochum (RUB) und der Medizinischen Fakultät der UDE am Universitätsklinikums Essen haben herausgefunden, auf welche Teile des Sars-Cov-2-Virus das menschliche Immunsystem reagiert: Neben dem bisher fokussierten Spike-Protein können auch zwei weitere Proteine eine starke Immunantwort auslösen.

Deutsch-chinesische Forschung Schwere COVID-19-Verläufe früh erkennen
[30.04.2020] Viele COVID-19-Erkrankungen verlaufen mild. Aber etwa zehn Prozent der Erkrankten entwickeln eine schwere Lungenentzündung und benötigen intensivmedizinische Versorgung. Um frühzeitig die richtigen therapeutischen Schritte einleiten zu können, ist es wichtig, potentiell gefährdete Patienten zu identifizieren. Gemeinsam mit chinesischen Kollegen am Wuhan Union Hospital haben Wissenschaftler des Instituts für Virologie der Medizinischen Fakultät der UDE festgestellt, dass die T-Zell-Population ein wichtiger Indikator ist. Diese Studie ist jetzt in The Lancet EBiomedicine online veröffentlicht.

Schilddrüse beeinflusst Hirnleistung stärker als gedacht Gut fürs Gedächtnis
[17.04.2020] Schilddrüsenhormone fördern unmittelbar die Bildung von Nervenzellen im Lern- und Gedächtniszentrum des Gehirns. Das belegen Forschungen der Medizinischen Fakultät der UDE und der University of Edinburgh erstmals. Die Ergebnisse liefern neben wichtigen Grundlagenerkenntnissen auch neue Ansatzpunkte, wie die geistige Leistungsfähigkeit mithilfe der Medizin verbessert werden kann. Das renommierte Stem Cell Reports berichtet.
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Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache : A multicentre, double-blind, randomised controlled trialIn: The Lancet Neurology Vol. 20 (2021) Nr. 1, pp. 29 - 37
ISSN: 1474-4465; 1474-4422Online Full Text: dx.doi.org/ -
Corrigendum to “Inhibiting fibroblast growth factor receptors in cancer – The next generation”In: Annals of Oncology Vol. 32 (2021) Nr. 1, pp. 126
ISSN: 1569-8041; 0923-7534Online Full Text: dx.doi.org/ (Open Access) -
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapyIn: Nature Communications Vol. 12 (2021) Nr. 1, pp. 346
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in MitosisIn: Molecular Cell Vol. 81 (2021) Nr. 1, pp. 67 - 87.e9
ISSN: 1097-4164; 1097-2765Online Full Text: dx.doi.org/ (Open Access)
ZMB Research Programs
Oncology
The concept of this research program is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments.
Participating researchers from biology, experimental and clinical medicine study tumors as “biological systems" and so called “neo-organs”.
A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.
Immunology, Infectious Diseases and Transplantation
The immune system responds to various pathogens including viruses and bacteria in different ways to prevent severe disease and persistence in the host. Many pathogens, however, have developed mechanisms to evade immune defence.
The molecular and cellular interactions of pathogens with the immune system are studied within this program.
Molecular and Chemical Cell Biology
Molecular and chemical cell biology is an interdisciplinary research program connecting molecular cell biology and genetics with chemistry and structural biology. Scientists of the participating disciplines collaborate to advance the understanding of basic molecular mechanisms of important biological processes.
The analysis of regulation and deregulation of key pathways is linking basic biology with pathophysiology.
Selected Publications 2021
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Altered mitochondria functionality defines a metastatic cell state in lung cancer and creates an exploitable vulnerabilityIn: Cancer Research Vol. 81 (2021) Nr. 3,
ISSN: 0008-5472; 1538-7445Online Full Text: dx.doi.org/ -
BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in MitosisIn: Molecular Cell Vol. 81 (2021) Nr. 1, pp. 67 - 87.e9
ISSN: 1097-4164; 1097-2765Online Full Text: dx.doi.org/ (Open Access) -
CDC20 assists its catalytic incorporation in the mitotic checkpoint complexIn: Science Vol. 371 (2021) Nr. 6524, pp. 67 - 71
ISSN: 1095-9203; 0036-8075Online Full Text: dx.doi.org/ -
Corrigendum to “Inhibiting fibroblast growth factor receptors in cancer – The next generation”In: Annals of Oncology Vol. 32 (2021) Nr. 1, pp. 126
ISSN: 1569-8041; 0923-7534Online Full Text: dx.doi.org/ (Open Access) -
Nab-paclitaxel plus gemcitabine versus nab-paclitaxel plus gemcitabine followed by FOLFIRINOX induction chemotherapy in locally advanced pancreatic cancer (NEOLAP-AIO-PAK-0113) : a multicentre, randomised, phase 2 trialIn: The Lancet Gastroenterology & Hepatology Vol. 6 (2021) Nr. 2, pp. 128 - 138
ISSN: 2468-1253Online Full Text: dx.doi.org/ -
Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal FluidIn: Immunity Vol. 54 (2021) Nr. 1, pp. 164
ISSN: 1097-4180; 1074-7613Online Full Text: dx.doi.org/ (Open Access) -
Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilizationIn: Science Advances Vol. 7 (2021) Nr. 3, pp. eabc8590
ISSN: 2375-2548Online Full Text: dx.doi.org/ (Open Access) -
Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache : A multicentre, double-blind, randomised controlled trialIn: The Lancet Neurology Vol. 20 (2021) Nr. 1, pp. 29 - 37
ISSN: 1474-4465; 1474-4422Online Full Text: dx.doi.org/ -
Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assembliesIn: Science Advances Vol. 7 (2021) Nr. 2, pp. eabd4413
ISSN: 2375-2548Online Full Text: dx.doi.org/ (Open Access) -
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapyIn: Nature Communications Vol. 12 (2021) Nr. 1, pp. 346
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access)
Journal articles
Selected Publications 2020
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A Supramolecular Stabilizer of the 14-3-3ζ/ERα Protein-Protein Interaction with a Synergistic Mode of ActionIn: Angewandte Chemie International Edition Vol. 132 (2020) Nr. 13, pp. 5322 - 5325
ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/ (Open Access) -
A clinical perspective on the 2019 ESC/EAS guidelines for the management of dyslipidaemias: PCSK-9 inhibitors for all?In: European Heart Journal Vol. 41 (2020) Nr. 24, pp. 2331
ISSN: 1522-9645Online Full Text: dx.doi.org/ -
A combined experimental and modelling approach for the Weimberg pathway optimisationIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 1098
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe diseaseIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 1338
ISSN: 2041-1723Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAFV⁶⁰⁰-mutant, stage III melanoma (COMBI-AD) : Exploratory biomarker analyses from a randomised, phase 3 trialIn: The Lancet Oncology Vol. 21 (2020) Nr. 3, pp. 358 - 372
ISSN: 1474-5488; 1470-2045Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Adjuvant nivolumab plus ipilimumab or nivolumab monotherapy versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED) : a randomised, double-blind, placebo-controlled, phase 2 trialIn: The Lancet Vol. 395 (2020) Nr. 10236, pp. 1558 - 1568
ISSN: 1474-547X; 0140-6736Online Full Text: dx.doi.org/ -
Association between Immune-Related Adverse Events and Recurrence-Free Survival among Patients with Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo : A Secondary Analysis of a Randomized Clinical TrialIn: JAMA Oncology Vol. 6 (2020) Nr. 4, pp. 519 - 527
ISSN: 2374-2445; 2374-2437Online Full Text: dx.doi.org/ (Open Access) -
Association of BRAF V600E/K Mutation Status and Prior BRAF/MEK Inhibition with Pembrolizumab Outcomes in Advanced Melanoma : Pooled Analysis of 3 Clinical TrialsIn: JAMA Oncology Vol. 6 (2020) Nr. 8, pp. 1256 - 1264
ISSN: 2374-2445; 2374-2437Online Full Text: dx.doi.org/ -
Author Correction: Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanomaIn: Nature Medicine Vol. 26 (2020) Nr. 7, pp. 1147
ISSN: 1546-170X; 1078-8956Online Full Text: dx.doi.org/ (Open Access) -
Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samplesIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 6232
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Author Correction: Tertiary lymphoid structures improve immunotherapy and survival in melanomaIn: Nature Vol. 580 (2020) Nr. 7801, pp. E1
ISSN: 1476-4687; 0028-0836Online Full Text: dx.doi.org/ -
Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeastIn: The EMBO Journal Vol. 39 (2020) Nr. 14, pp. e102938
ISSN: 1460-2075; 0261-4189Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR) : A multicentre, open-label, phase 1 trialIn: The Lancet Oncology Vol. 21 (2020) Nr. 7, pp. 935 - 946
ISSN: 1474-5488; 1470-2045Online Full Text: dx.doi.org/ -
Biochemical evidence for Ku-independent backup pathways of NHEJIn: Nucleic Acids Research Vol. 48 (2020) Nr. 9, pp. 5200
ISSN: 1362-4962; 0301-5610; 0305-1048Online Full Text: dx.doi.org/ (Open Access) -
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s diseaseIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4885
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Cancer cells stock up in lymph vessels to surviveIn: Nature Vol. 585 (2020) Nr. 7823, pp. 36 - 37
ISSN: 1476-4687; 0028-0836Online Full Text: dx.doi.org/ -
Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumoursIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 1335
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Cardiac fibroblast activation detected by positron emission tomography/computed tomography as a possible sign of cardiotoxicityIn: European Heart Journal Vol. 41 (2020) Nr. 9, pp. 1060
ISSN: 1522-9645; 0195-668XOnline Full Text: dx.doi.org/ -
Cemiplimab in locally advanced cutaneous squamous cell carcinoma : results from an open-label, phase 2, single-arm trialIn: The Lancet Oncology Vol. 21 (2020) Nr. 2, pp. 294 - 305
ISSN: 1474-5488; 1470-2045Online Full Text: dx.doi.org/ -
Co-option of Neutrophil Fates by Tissue EnvironmentsIn: Cell Vol. 183 (2020) Nr. 5, pp. 1282 - 1297.e18
ISSN: 1097-4172; 0092-8674Online Full Text: dx.doi.org/ -
Combined PD-1, BRAF and MEK inhibition in advanced BRAF-mutant melanoma : safety run-in and biomarker cohorts of COMBI-iIn: Nature Medicine Vol. 26 (2020) Nr. 10, pp. 1557 - 1563
ISSN: 1546-170X; 1078-8956Online Full Text: dx.doi.org/ -
Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 MortalityIn: Cell Vol. 183 (2020) Nr. 6, pp. 1508 - 1519.e12
ISSN: 1097-4172; 0092-8674Online Full Text: dx.doi.org/ (Open Access) -
Corrigendum to “Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics” [Biomaterials 192 (2019) 551–559]In: Biomaterials Vol. 263 (2020) pp. 120371
ISSN: 1878-5905; 0142-9612Online Full Text: dx.doi.org/ -
Durable and controlled depletion of neutrophils in miceIn: Nature Communications Vol. 11 (2020) pp. 2762
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Elevated baseline serum PD-1 or PD-L1 predicts poor outcome of PD-1 inhibition therapy in metastatic melanomaIn: Annals of Oncology Vol. 31 (2020) Nr. 1, pp. 144 - 152
ISSN: 1569-8041; 0923-7534Online Full Text: dx.doi.org/ -
External validation of models for KIR2DS1/KIR3DL1-informed selection of hematopoietic cell donors failsIn: Blood Vol. 135 (2020) Nr. 16, pp. 1386 - 1395
ISSN: 1528-0020; 0006-4971Online Full Text: dx.doi.org/ -
Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injuryIn: Gut Vol. 69 (2020) Nr. 1, pp. 133 - 145
ISSN: 1468-3288; 0017-5749Online Full Text: dx.doi.org/ (Open Access) -
From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins : the chemical biology of Ahp-cyclodepsipeptidesIn: Natural Product Reports Vol. 37 (2020) Nr. 2, pp. 163 - 174
ISSN: 0265-0568; 1460-4752Online Full Text: dx.doi.org/ -
Functional Disruption of the Cancer-Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole LigandIn: Angewandte Chemie International Edition Vol. 59 (2020) Nr. 14, pp. 5567 - 5571
ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/ (Open Access) -
Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibilityIn: Nature Genetics Vol. 52 (2020) Nr. 5, pp. 494 - 504
ISSN: 1546-1718; 1061-4036Online Full Text: dx.doi.org/ -
Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypesIn: Blood Vol. 136 (2020) Nr. 12, pp. 1419 - 1432
ISSN: 1528-0020Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Heterobifunctional Rotaxanes for Asymmetric CatalysisIn: Angewandte Chemie International Edition Vol. 59 (2020) Nr. 13, pp. 5102 - 5107
ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/ (Open Access) -
Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK PathwayIn: Cancer Research Vol. 80 (2020) Nr. 21, pp. 4655 - 4667
ISSN: 0008-5472; 1538-7445; 0099-7013; 0099-7374Online Full Text: dx.doi.org/ -
Inhibition of haspin kinase promotes cell-intrinsic and extrinsic antitumor activityIn: Cancer Research Vol. 80 (2020) Nr. 4, pp. 798 - 810
ISSN: 1538-7445; 0008-5472Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Integrated molecular drivers coordinate biological and clinical states in melanomaIn: Nature Genetics Vol. 52 (2020) Nr. 12, pp. 1373 - 1383
ISSN: 1546-1718; 1061-4036Online Full Text: dx.doi.org/ -
Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiationIn: Nucleic Acids Research Vol. 48 (2020) Nr. 6, pp. 3396
ISSN: 1362-4962; 0301-5610; 0305-1048Online Full Text: dx.doi.org/ (Open Access) -
Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signalingIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 3547
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphomaIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 2465
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Metabolic heterogeneity confers differences in melanoma metastatic potentialIn: Nature Vol. 577 (2020) Nr. 7788, pp. 115 - 120
ISSN: 1476-4687; 0028-0836Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Molecular correlates of response to capmatinib in advanced non-small-cell lung cancer : Clinical and biomarker results from a phase I trialIn: Annals of Oncology (2020)
ISSN: 1569-8041; 0923-7534Online Full Text: dx.doi.org/ (Open Access) -
Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterationsIn: Acta Neuropathologica Vol. 139 (2020) Nr. 2, pp. 243 - 257
ISSN: 1432-0533; 0001-6322Online Full Text: dx.doi.org/ -
Non-classical monocyte homing to the gut via α4β7 integrin mediates macrophage-dependent intestinal wound healingIn: Gut Vol. 69 (2020) pp. 252 - 263
ISSN: 1468-3288; 0017-5749Online Full Text: dx.doi.org/ -
Nusinersen in adults with 5q spinal muscular atrophy : A non-interventional, multicentre, observational cohort studyIn: The Lancet Neurology Vol. 19 (2020) Nr. 4, pp. 317 - 325
ISSN: 1474-4465; 1474-4422Online Full Text: dx.doi.org/ -
PD-1 Blockade in Anaplastic Thyroid CarcinomaIn: Journal of Clinical Oncology Vol. 38 (2020) Nr. 23, pp. 2620 - 2627
ISSN: 1527-7755Online Full Text: dx.doi.org/ (Open Access) -
Pan-cancer analysis of whole genomesIn: Nature Vol. 578 (2020) Nr. 7793, pp. 82 - 93
ISSN: 0028-0836; 1476-4687Online Full Text: dx.doi.org/ (Open Access) -
Peptide and peptide-based inhibitors of SARS-CoV-2 entryIn: Advanced Drug Delivery Reviews Vol. 167 (2020) pp. 47 - 65
ISSN: 1872-8294; 0169-409XOnline Full Text: dx.doi.org/ (Open Access) -
Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DMIn: Blood (2020) in press
ISSN: 0006-4971; 1528-0020Online Full Text: dx.doi.org/ -
Post-transplantation cyclophosphamide GvHD prophylaxis after hematopoietic stem cell transplantation from 9/10 or 10/10 HLA-matched unrelated donors for acute leukemiaIn: Leukemia (2020)
ISSN: 1476-5551; 0887-6924Online Full Text: dx.doi.org/ -
Predominance of Central Memory T Cells with High T-Cell Receptor Repertoire Diversity is Associated with Response to PD-1/PD-L1 Inhibition in Merkel Cell CarcinomaIn: Clinical Cancer Research Vol. 26 (2020) Nr. 9, pp. 2257 - 2267
ISSN: 1078-0432; 1557-3265Online Full Text: dx.doi.org/ -
Present and Future of Surface-Enhanced Raman ScatteringIn: ACS Nano Vol. 14 (2020) Nr. 1, pp. 28 - 117
ISSN: 1936-086X; 1936-0851Online Full Text: dx.doi.org/ (Open Access) -
Prognosis of patients with stage III melanoma according to American joint committee on cancer version 8 : A reassessment on the basis of 3 independent stage III melanoma cohortsIn: Journal of Clinical Oncology Vol. 38 (2020) Nr. 22, pp. 2543 - 2551
ISSN: 1527-7755; 0732-183XOnline Full Text: dx.doi.org/ (Open Access) -
Prognostic impact of baseline tumour immune infiltrate on disease-free survival in patients with completely resected, BRAFv⁶⁰⁰ mutation–positive melanoma receiving adjuvant vemurafenibIn: Annals of Oncology Vol. 31 (2020) Nr. 1, pp. 153 - 159
ISSN: 1569-8041; 0923-7534Online Full Text: dx.doi.org/ -
Quality of life (QoL) and self-reported function with ripretinib in ≥4th-line therapy for patients with gastrointestinal stromal tumors (GIST) : Analyses from INVICTUSIn: Journal of Clinical Oncology Vol. 38 (2020) Nr. 15_Suppl., pp. 11535
ISSN: 0732-183X; 1527-7755Online Full Text: dx.doi.org/ -
Randomized Comparison of Pazopanib and Doxorubicin as First-Line Treatment in Patients with Metastatic Soft Tissue Sarcoma Age 60 Years or Older : Results of a German Intergroup StudyIn: Journal of Clinical Oncology Vol. 38 (2020) Nr. 30, pp. 3555 - 3564
ISSN: 1527-7755; 0732-183XOnline Full Text: dx.doi.org/ -
Rationale for Immune Checkpoint Inhibitors plus Targeted Therapy in Metastatic Melanoma : A ReviewIn: JAMA Oncology (2020) in press
ISSN: 2374-2445; 2374-2437Online Full Text: dx.doi.org/ -
Refining endpoints for stroke recovery trialsIn: The Lancet Neurology Vol. 19 (2020) Nr. 5, pp. 381 - 382
ISSN: 1474-4465; 1474-4422Online Full Text: dx.doi.org/ -
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samplesIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4748
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS) : a double-blind, randomised, placebo-controlled, phase 3 trialIn: The Lancet Oncology Vol. 21 (2020) Nr. 7, pp. 923 - 934
ISSN: 1474-5488; 1470-2045Online Full Text: dx.doi.org/ -
Role of HLA-DP Expression in Graft-Versus-Host Disease After Unrelated Donor TransplantationIn: Journal of Clinical Oncology Vol. 38 (2020) Nr. 24, pp. 2712 - 2718
ISSN: 1527-7755; 0732-183XOnline Full Text: dx.doi.org/ -
STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosisIn: Gut Vol. 69 (2020) Nr. 7, pp. 1269 - 1282
ISSN: 0017-5749Online Full Text: dx.doi.org/ -
Safety and Efficacy of 48 Weeks REP 2139 or REP 2165, Tenofovir Disoproxil, and Pegylated Interferon Alfa-2a in Patients With Chronic HBV Infection Naïve to Nucleos(t)ide TherapyIn: Gastroenterology Vol. 158 (2020) Nr. 8, pp. 2180 - 2194
ISSN: 1528-0012; 0016-5085Online Full Text: dx.doi.org/ -
Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke : A multicentre, double-blind, randomised, placebo-controlled trialIn: The Lancet Neurology Vol. 19 (2020) Nr. 3, pp. 226 - 233
ISSN: 1474-4465; 1474-4422Online Full Text: dx.doi.org/ -
Safety profile of ripretinib, including impact of alopecia, and Palmar-Plantar Erythrodysesthesia Syndrome (PPES) on patient-reported outcomes (PROs), in ≥ fourth-line advanced gastrointestinal stromal tumors (GIST) : Analyses from INVICTUSIn: Journal of Clinical Oncology Vol. 38 (2020) Nr. 15_Suppl., pp. 11539
ISSN: 0732-183X; 1527-7755Online Full Text: dx.doi.org/ -
Sex differences in oncogenic mutational processesIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4330
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52In: Nucleic Acids Research Vol. 48 (2020) Nr. 4, pp. 1905 - 1924
ISSN: 1362-4962; 0305-1048Online Full Text: dx.doi.org/ (Open Access) -
Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactionsIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 3954
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Tertiary lymphoid structures improve immunotherapy and survival in melanomaIn: Nature Vol. 577 (2020) Nr. 7791, pp. 561 - 565
ISSN: 0028-0836; 1476-4687Online Full Text: dx.doi.org/ -
The quest for efficient trial designs in precision oncologyIn: The Lancet Oncology Vol. 21 (2020) Nr. 12, pp. 1539 - 1541
ISSN: 1474-5488; 1470-2045Online Full Text: dx.doi.org/ -
Towards Reliable and Quantitative Surface-Enhanced Raman Scattering (SERS) : From Key Parameters to Good Analytical PracticeIn: Angewandte Chemie International Edition Vol. 59 (2020) pp. 5454 - 5462
ISSN: 1521-3773; 1433-7851Online Full Text: dx.doi.org/ (Open Access) -
mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerabilityIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4684
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access)
Journal articles
Selected Publications 2019
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A TetR-family transcription factor regulates fatty acid metabolism in the archaeal model organism Sulfolobus acidocaldariusIn: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1542
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus : the MONO studyIn: Annals of Oncology Vol. 30 (2019) Nr. 9, pp. 1487 - 1495
ISSN: 1569-8041; 0923-7534Online Full Text: dx.doi.org/ (Open Access) -
A newly discovered stem cell that keeps bones growingIn: Nature Vol. 567 (2019) Nr. 7747, pp. 178 - 179
ISSN: 0028-0836; 1476-4687Online Full Text: dx.doi.org/ -
Activity and tolerability of BLU-667, a highly potent and selective RET inhibitor, in patients with advanced RET-altered thyroid cancersIn: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15_Suppl, pp. 6018
ISSN: 0732-183X; 1527-7755Online Full Text: dx.doi.org/ -
Alpelisib Plus Fulvestrant in PIK3CA -Altered and PIK3CA -Wild-Type Estrogen Receptor-Positive Advanced Breast Cancer : A Phase 1b Clinical TrialIn: JAMA Oncology Vol. 5 (2019) Nr. 2, pp. e184475
ISSN: 2374-2445; 2374-2437Online Full Text: dx.doi.org/ -
Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphomaIn: Blood Vol. 134 (2019) Nr. 13, pp. 1072 - 1083
ISSN: 1528-0020; 0006-4971Online Full Text: dx.doi.org/ -
Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing : Implications for the design of improved nanoantibioticsIn: Biomaterials Vol. 192 (2019) pp. 551 - 559
ISSN: 0142-9612; 1878-5905Online Full Text: dx.doi.org/ -
Bortezomib-based induction therapy with high or low-dose dexamethasone in newly diagnosed, transplant-eligible multiple myelomaIn: Leukemia Vol. 33 (2019) Nr. 7, pp. 258 - 261
ISSN: 0887-6924; 1476-5551Online Full Text: dx.doi.org/ -
Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal CancerIn: Immunity Vol. 50 (2019) Nr. 1, pp. 166 - 180.e7
ISSN: 1097-4180; 1074-7613Online Full Text: dx.doi.org/ (Open Access) -
Circulating tumor DNA (ctDNA) kinetics to predict survival in patients (pts) with unresectable or metastatic melanoma treated with dabrafenib (D) or D + trametinib (T)In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15_suppl, pp. 9510
ISSN: 0732-183X; 1527-7755Online Full Text: dx.doi.org/ -
Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and responseIn: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2312
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Control of TLR7-mediated type i IFN signaling in pDCs through CXCR4 engagement - A new target for lupus treatmentIn: Science Advances Vol. 5 (2019) Nr. 7, pp. eaav9019
ISSN: 2375-2548Online Full Text: dx.doi.org/ (Open Access) -
Covalent-Allosteric Inhibitors to Achieve Akt Isoform-SelectivityIn: Angewandte Chemie International Edition Vol. 58 (2019) Nr. 52, pp. 18823 - 18829
ISSN: 1433-7851; 1521-3773Online Full Text: dx.doi.org/ (Open Access) -
Current gaps in sepsis immunology: new opportunities for translational researchIn: The Lancet Infectious Diseases Vol. 19 (2019) Nr. 12, pp. e422 - e436
ISSN: 1474-4457; 1473-3099Online Full Text: dx.doi.org/ (Open Access) -
Distinct immunogenomic properties of melanomas with stable disease as best response to immune checkpoint blockade (ICB)In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15_Suppl, pp. 2515 - 2515
ISSN: 0732-183X; 1527-7755Online Full Text: dx.doi.org/ -
Dynamic Risk Profiling Using Serial Tumor Biomarkers for Personalized Outcome PredictionIn: Cell Vol. 178 (2019) Nr. 3, pp. 699 - 713.e19
ISSN: 0092-8674; 1097-4172Online Full Text: dx.doi.org/ (Open Access) -
Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and MetastasisIn: Cancer Cell Vol. 36 (2019) Nr. 3, pp. 319 - 336.e7
ISSN: 1535-6108Online Full Text: dx.doi.org/ (Open Access) -
Evaluation of Two Dosing Regimens for Nivolumab in Combination With Ipilimumab in Patients With Advanced Melanoma : Results From the Phase IIIb/IV CheckMate 511 TrialIn: Journal of Clinical Oncology Vol. 37 (2019) Nr. 11, pp. 867 - 875
ISSN: 0732-183X; 1527-7755Online Full Text: dx.doi.org/ (Open Access) -
Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell deathIn: Nature Vol. 569 (2019) Nr. 7755, pp. 236 - 240
ISSN: 0028-0836; 1476-4687Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Final results of a multicenter, open-label phase 2 clinical trial (MYR203) to assess safety and efficacy of myrcludex B in cwith PEG-interferon Alpha 2a in patients with chronic HBV/HDV co-infectionIn: Journal of Hepatology Vol. 70 (2019) Nr. 1 Suppl., pp. e81
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Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced MelanomaIn: The New England Journal of Medicine Vol. 381 (2019) Nr. 16, pp. 1535 - 1546
ISSN: 1533-4406Online Full Text: dx.doi.org/ -
Five-year outcomes with dabrafenib plus trametinib in metastatic melanomaIn: The New England Journal of Medicine Vol. 381 (2019) Nr. 7, pp. 626 - 636
ISSN: 1533-4406; 0028-4793Online Full Text: dx.doi.org/ -
Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunityIn: FEMS Microbiology Reviews Vol. 43 (2019) Nr. 5, pp. 435 - 456
ISSN: 1574-6976; 0168-6445Online Full Text: dx.doi.org/ -
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosaIn: Nature Genetics Vol. 51 (2019) Nr. 8, pp. 1207 - 1214
ISSN: 1061-4036; 1546-1718Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Genomes of Subaerial Zygnematophyceae Provide Insights into Land Plant EvolutionIn: Cell Vol. 179 (2019) Nr. 5, pp. 1057 - 1067.e14
ISSN: 0092-8674; 0092-8674Online Full Text: dx.doi.org/ -
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms Across Eight Psychiatric DisordersIn: Cell Vol. 179 (2019) Nr. 7, pp. 1469 - 1482.e11.
ISSN: 0092-8674; 1097-4172Online Full Text: dx.doi.org/ -
Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphomaIn: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1459
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptidesIn: Science Vol. 364 (2019) Nr. 6436, pp. eaav0748
ISSN: 1095-9203; 0036-8075Online Full Text: dx.doi.org/ -
HDAC8 regulates a stress response pathway in melanoma to mediate escape from BRAF inhibitor therapyIn: Cancer Research Vol. 79 (2019) Nr. 11, pp. 2947 - 2961
ISSN: 0008-5472; 0099-7013; 0099-7374; 1538-7445Online Full Text: dx.doi.org/ -
Immune signature drives leukemia escape and relapse after hematopoietic cell transplantationIn: Nature Medicine Vol. 25 (2019) Nr. 4, pp. 603 - 611
ISSN: 1546-170X; 1078-8956Online Full Text: dx.doi.org/ -
Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanomaIn: Nature Medicine Vol. 25 (2019) Nr. 12, pp. 1916 - 1927
ISSN: 1078-8956; 1546-170XOnline Full Text: dx.doi.org/ (Open Access) -
MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt LymphomaIn: Cancer Research Vol. 79 (2019) Nr. 12, pp. 3125 - 3138
ISSN: 1538-7445; 0008-5472Online Full Text: dx.doi.org/ -
MMP2/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearanceIn: Journal of Hepatology Vol. 71 (2019) Nr. 4, pp. 685 - 698
ISSN: 1600-0641; 0168-8278Online Full Text: dx.doi.org/ -
Machine learning-based predictors for immune checkpoint inhibitor therapy of non-small-cell lung cancerIn: Annals of Oncology Vol. 30 (2019) Nr. 4, pp. 655 - 657
ISSN: 1569-8041; 0923-7534Online Full Text: dx.doi.org/ (Open Access) -
Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensingIn: Nature Communications Vol. 10 (2019) Nr. 1, pp. 4046
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Melanoma extracellular vesicles generate immunosuppressive myeloid cells by upregulating PD-L1 via TLR4 signalingIn: Cancer Research Vol. 79 (2019) Nr. 18, pp. 4715 - 4728
ISSN: 0099-7013; 0008-5472Online Full Text: dx.doi.org/ -
Microglial cell loss after ischemic stroke favors brain neutrophil accumulationIn: Acta Neuropathologica Vol. 137 (2019) Nr. 2, pp. 321 - 341
ISSN: 1432-0533; 0001-6322Online Full Text: dx.doi.org/ (Open Access) -
Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosinIn: Nature Communications Vol. 10 (2019) Nr. 1, pp. 4781
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8⁺ T Cells and Evolve at the Population LevelIn: Gastroenterology Vol. 156 (2019) Nr. 6, pp. 1820 - 1833
ISSN: 0016-5085; 1528-0012Online Full Text: dx.doi.org/ (Open Access) -
Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF melanoma (PACMEL) : a multicentre, open-label, randomised, controlled phase II trialIn: Annals of Oncology Vol. 30 (2019) Nr. 2, pp. 317 - 324
ISSN: 1569-8041; 0923-7534Online Full Text: dx.doi.org/ (Open Access) -
Patient-reported outcomes in patients with resected, high-risk melanoma with BRAFV600E or BRAFV600K mutations treated with adjuvant dabrafenib plus trametinib (COMBI-AD) : a randomised, placebo-controlled, phase 3 trialIn: The Lancet Oncology Vol. 20 (2019) Nr. 5, pp. 701 - 710
ISSN: 1474-5488Online Full Text: dx.doi.org/ -
Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4) : a randomised, phase 2/3 trialIn: The Lancet Vol. 393 (2019) Nr. 10184, pp. 1948 - 1957
ISSN: 0140-6736; 0023-7507; 1474-547XOnline Full Text: dx.doi.org/ -
Positron Emission Tomography-Guided Treatment in Early-Stage Favorable Hodgkin Lymphoma : Final Results of the International, Randomized Phase III HD16 Trial by the German Hodgkin Study GroupIn: Journal of Clinical Oncology Vol. 37 (2019) Nr. 31, pp. 2835 - 2845
ISSN: 1527-7755; 0732-183XOnline Full Text: dx.doi.org/ -
Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal CancerIn: Cancer Research Vol. 79 (2019) Nr. 9, pp. 2367 - 2378
ISSN: 0008-5472; 1538-7445; 0099-7013; 0099-7374Online Full Text: dx.doi.org/ -
Publisher Correction : Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathwaysIn: Nature Communications Vol. 10 (2019) Nr. 1, pp. 299
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Publisher Correction: Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and responseIn: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2768
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Publisher Correction: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathwaysIn: Nature Communications Vol. 10 (2019) Nr. 1, pp. 299
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Quality of life (QoL) and symptom burden in patients (pts) with advanced melanoma during the treatment-free interval (TFI) after discontinuation of nivolumab (NIVO) or NIVO plus ipilimumab (IPI)In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15_Suppl, pp. 9568
ISSN: 0732-183X; 1527-7755Online Full Text: dx.doi.org/ -
Randomized phase III trial of ibrutinib and rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in non–germinal center B-cell diffuse large B-cell lymphomaIn: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15, pp. 1285 - 1295
ISSN: 0732-183X; 1527-7755Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Rapid, Quantitative, and Ultrasensitive Point-of-Care Testing : A Portable SERS Reader for Lateral Flow Assays in Clinical ChemistryIn: Angewandte Chemie International Edition Vol. 58 (2019) Nr. 2, pp. 442 - 446
ISSN: 1521-3773; 1433-7851Online Full Text: dx.doi.org/ (Open Access) -
Reply to E. Hindié and K.R. HessIn: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15, pp. 1356 - 1358
ISSN: 0732-183X; 1527-7755Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Reply to J. Wang et alIn: Journal of Clinical Oncology Vol. 37 (2019) Nr. 9, pp. 755 - 758
ISSN: 0732-183X; 1527-7755Online Full Text: dx.doi.org/ -
Rogaratinib in patients with advanced cancers selected by FGFR mRNA expression : a phase 1 dose-escalation and dose-expansion studyIn: The Lancet Oncology Vol. 20 (2019) Nr. 10, pp. 1454 - 1466
ISSN: 1470-2045; 1474-5488Online Full Text: dx.doi.org/ -
Salvage therapy after failure from anti-PD-1 single agent treatment : A Study by the German ADOReg melanoma registryIn: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15_Suppl, pp. 9505
ISSN: 0732-183X; 1527-7755Online Full Text: dx.doi.org/ -
Sites of high local frustration in DNA origamiIn: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1061
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Survival Outcomes in Patients with Previously Untreated BRAF Wild-Type Advanced Melanoma Treated with Nivolumab Therapy : Three-Year Follow-up of a Randomized Phase 3 TrialIn: JAMA Oncology Vol. 5 (2019) Nr. 2, pp. 187 - 194
ISSN: 2374-2445; 2374-2437Online Full Text: dx.doi.org/ -
The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholambanIn: EMBO Reports Vol. 20 (2019) Nr. 3, pp. e46449
ISSN: 1469-3178; 1469-221XOnline Full Text: dx.doi.org/ Online Full Text (Open Access) -
The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damageIn: EMBO Reports (2019) pp. e48014
ISSN: 1469-3178; 1469-221XOnline Full Text: dx.doi.org/ (Open Access) -
Treatment in metastatic melanoma : Time to re-thinkIn: Annals of Oncology Vol. 30 (2019) Nr. 4, pp. 501 - 503
ISSN: 0923-7534; 1569-8041Online Full Text: dx.doi.org/ (Open Access) -
Understanding HDV and HBsAg kinetics during nucleic acid polymer REP 2139 mono-therapy in HBeAg-negative chronic HBV/HDV co-infected patients via mathematical modelingIn: Journal of Hepatology Vol. 70 (2019) Nr. 1 Suppl., pp. e463
ISSN: 0168-8278Online Full Text: dx.doi.org/ -
Unstable TTTTA/TTTCA expansions in MARCH6 are associated with Familial Adult Myoclonic Epilepsy type 3In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 4919
ISSN: 2041-1723Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Viral escape contributes to the failure of hepatitis D virus-specific CD8+ T-cells and drives evolution of HDVIn: Journal of Hepatology Vol. 70 (2019) Nr. Suppl. 1, pp. e21
ISSN: 0168-8278Online Full Text: dx.doi.org/ -
Weightlifting unmasks high-risk coronary anomalyIn: European Heart Journal Vol. 40 (2019) Nr. 1, pp. 72
ISSN: 0195-668X; 1522-9645Online Full Text: dx.doi.org/ -
Zolbetuximab combined with EOX as first-line therapy in advanced CLDN18.2+ gastric (G) and gastroesophageal junction (GEJ) adenocarcinoma : Updated results from the FAST trial.In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 4_Suppl, pp. 16
ISSN: 0732-183X; 1527-7755Online Full Text: dx.doi.org/ -
ctDNA as a noninvasive monitoring tool in metastatic melanomaIn: Journal of Clinical Oncology Vol. 37 (2019) Nr. Suppl. 15, pp. 9548
ISSN: 0732-183X; 1527-7755Online Full Text: dx.doi.org/
Journal articles
Selected Publications 2018
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A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint BlockadeIn: Cell Vol. 175 (2018) Nr. 4, pp. 984 - 997.e24
ISSN: 1097-4172; 0092-8674Online Full Text: dx.doi.org/ (Open Access) -
A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPasesIn: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 6, pp. 1576 - 1580
ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/ -
A critical view on transgenerational epigenetic inheritance in humansIn: Nature Communications Vol. 9 (2018) Nr. 1, pp. 2973
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
A distinct oncogenerative multinucleated cancer cell serves as a source of stemness and tumor heterogeneityIn: Cancer Research Vol. 78 (2018) Nr. 9, pp. 2318 - 2331
ISSN: 0008-5472; 1538-7445Online Full Text: dx.doi.org/ -
A mechanistic classification of clinical phenotypes in neuroblastomaIn: Science Vol. 362 (2018) Nr. 6419, pp. 1165 - 1170
ISSN: 1095-9203; 0036-8075Online Full Text: dx.doi.org/ -
Adjuvant melanoma therapy with new drugs : should physicians continue to focus on metastatic disease or use it earlier in primary melanoma?In: The Lancet Oncology Vol. 19 (2018) Nr. 12, pp. e720 - e725
ISSN: 1470-2045; 1474-5488Online Full Text: dx.doi.org/ -
Adjuvant pembrolizumab versus placebo in resected stage III melanomaIn: The New England Journal of Medicine Vol. 378 (2018) Nr. 19, pp. 1789 - 1801
ISSN: 1533-4406; 0028-4793Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Adjuvant vemurafenib in resected, BRAF mutation-positive melanoma (BRIM8) : a randomised, double-blind, placebo-controlled, multicentre, phase 3 trialIn: The Lancet Oncology Vol. 19 (2018) Nr. 4, pp. 510 - 520
ISSN: 1470-2045; 1474-5488Online Full Text: dx.doi.org/ -
Adverse events (AEs) over time in patients (pts) treated with adjuvant dabrafenib plus trametinib (D + T) or placebo (Pbo) in the COMBI-AD trialIn: Annals of Oncology: official journal of the European Society for Medical Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii446
ISSN: 0923-7534; 1569-8041Online Full Text: dx.doi.org/ (Open Access) -
Age correlates with response to anti-PD1, reflecting age-related differences in intratumoral effector and regulatory T-Cell populationsIn: Clinical Cancer Research Vol. 24 (2018) Nr. 21, pp. 5347 - 5356
ISSN: 1078-0432; 1557-3265Online Full Text: dx.doi.org/ -
An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphomaIn: Leukemia Vol. 32 (2018) Nr. 1, pp. 92 - 101
ISSN: 0887-6924; 1476-5551Online Full Text: dx.doi.org/ -
Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramideIn: Molecular Psychiatry Vol. 23 (2018) pp. 2324 - 2346
ISSN: 1476-5578; 1359-4184Online Full Text: dx.doi.org/ (Open Access) -
Antidepressants regulate autophagy by targeting acid sphingomyelinaseIn: Molecular Psychiatry Vol. 23 (2018) Nr. 12, pp. 2251
ISSN: 1359-4184; 1476-5578Online Full Text: dx.doi.org/ -
Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy : a retrospective, multicohort analysisIn: The Lancet Oncology Vol. 19 (2018) Nr. 3, pp. 310 - 322
ISSN: 1470-2045Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Author Correction : The landscape of genomic alterations across childhood cancersIn: Nature Vol. 559 (2018) Nr. 7714, pp. E10
ISSN: 0028-0836; 1476-4687Online Full Text: dx.doi.org/ -
Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individualsIn: Blood Vol. 131 (2018) Nr. 5, pp. 546 - 557
ISSN: 1528-0020; 0006-4971Online Full Text: dx.doi.org/ (Open Access) -
Bortezomib before and after high-dose therapy in myeloma : Long-term results from the phase III HOVON-65/GMMG-HD4 trialIn: Leukemia Vol. 32 (2018) Nr. 2, pp. 383 - 390
ISSN: 1476-5551; 0887-6924Online Full Text: dx.doi.org/ -
CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infectionIn: Nature Communications Vol. 9 (2018) pp. 2561
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 BlockadeIn: Cell Vol. 173 (2018) Nr. 3, pp. 624 - 633.e8
ISSN: 1097-4172; 0092-8674Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Cell entry of a host-targeting protein of oomycetes requires gp96In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 2347
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Circulating cell-free miR-375 as surrogate marker of tumor burden in Merkel cell carcinomaIn: Clinical Cancer Research Vol. 24 (2018) Nr. 23, pp. 5873 - 5882
ISSN: 1078-0432; 1557-3265Online Full Text: dx.doi.org/ -
Circulating tumor DNA measurements as early outcome predictors in diffuse large B-Cell lymphomaIn: Journal of Clinical Oncology Vol. 36 (2018) Nr. 28, pp. 2845 - 2853
ISSN: 0732-183X; 1527-7755Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Clinical Relevance and Suppressive Capacity of Human Myeloid-Derived Suppressor Cell SubsetsIn: Clinical Cancer Research Vol. 24 (2018) Nr. 19, pp. 4834 - 4844
ISSN: 1078-0432; 1557-3265Online Full Text: dx.doi.org/ -
Consensus statement on mandatory measurements in pancreatic cancer trials (COMM-PACT) for systemic treatment of unresectable diseaseIn: The Lancet Oncology Vol. 19 (2018) Nr. 3, pp. e151 - e160
ISSN: 1470-2045; 1474-5488Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Correction: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosaIn: Molecular Psychiatry Vol. 23 (2018) Nr. 9, pp. 1
ISSN: 1476-5578; 1359-4184Online Full Text: dx.doi.org/ -
Corrigendum: Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cellsIn: EMBO Reports Vol. 19 (2018) Nr. 12, pp. e47190
ISSN: 1469-221X; 1469-3178Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Critical influences on the pathogenesis of follicular lymphomaIn: Blood Vol. 131 (2018) Nr. 21, pp. 2297 - 2306
ISSN: 1528-0020; 0006-4971Online Full Text: dx.doi.org/ -
DNA methylation-based classification of central nervous system tumoursIn: Nature Vol. 555 (2018) Nr. 7697, pp. 469 - 474
ISSN: 0028-0836; 1476-4687Online Full Text: dx.doi.org/ (Open Access) -
Decreased appetite (DA) at baseline impacts prognosis in the NAPOLI-1 phase 3 study in metastatic pancreatic ductal adenocarcinoma (mPDAC)In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 5, pp. v42 - v43
ISSN: 0923-7534; 1569-8041Online Full Text: dx.doi.org/ (Open Access) -
Development of predictors for PD-1/PD-L1-directed therapy of non-small cell lung cancer (NSCLC) by gene expression profiling of small diagnostic biopsies (DBX)In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 15 Suppl., pp. e15121
ISSN: 0732-183X; 1527-7755Online Full Text: dx.doi.org/ -
Discovering novel hydrolases from hot environmentsIn: Biotechnology Advances Vol. 36 (2018) Nr. 8, pp. 2077 - 2100
ISSN: 0734-9750; 1873-1899Online Full Text: dx.doi.org/ (Open Access) -
Distinct Gene Expression Patterns Drive Proliferation of Dominant-Negative RUNX1 Immortalized HSPCs
60th ASH Annual Meeting; December 1-4, 2018; San Diego, USA,In: Blood Vol. 132 (2018) Nr. Supplement 1, pp. 1795 - 1795
ISSN: 1528-0020; 0006-4971Online Full Text: dx.doi.org/ -
Effect of UV irradiation on Sulfolobus acidocaldarius and involvement of the general transcription factor TFB3 in the early UV responseIn: Nucleic Acids Research Vol. 46 (2018) Nr. 14, pp. 7179 - 7192
ISSN: 1362-4962; 0301-5610; 0305-1048Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS) : a multicentre, open-label, randomised phase 3 trialIn: The Lancet Oncology Vol. 19 (2018) Nr. 5, pp. 603 - 615
ISSN: 1470-2045; 1474-5488Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access) -
Estimate of long-term relapse-free survival (RFS) and analysis of baseline factors associated with RFS in the COMBI-AD trialIn: Annals of Oncology: official journal of the European Society for Medical Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii445
ISSN: 0923-7534; 1569-8041Online Full Text: dx.doi.org/ (Open Access) -
Evolution of the Optical Gap in the Acene Series : UndecaceneIn: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 33, pp. 10506 - 10509
ISSN: 1521-3773; 1433-7851Online Full Text: dx.doi.org/ -
Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumorsIn: Nature Genetics Vol. 50 (2018) Nr. 9, pp. 1271 - 1281
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Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMsIn: The EMBO Journal Vol. 37 (2018) Nr. 13,
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Hierarchical Assembly of DNA Filaments with Designer Elastic PropertiesIn: ACS Nano Vol. 12 (2018) Nr. 1, pp. 44 - 55
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IG-MYC⁺ neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomasIn: Blood Vol. 132 (2018) Nr. 21, pp. 2280 - 2285
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Impact of dose reduction or dose delay on the efficacy of liposomal irinotecan (nal-IRI)+5-fluorouracil/leucovorin (5-FU/LV) : Survival analysis from NAPOLI-1In: Annals of Oncology: official journal of the European Society for Medical Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii250 - viii251
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Insights into the evolutionary conserved regulation of Rio ATPase activity.In: Nucleic Acids Research Vol. 46 (2018) Nr. 3, pp. 1441 - 1456
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Integrated genomic classification of melanocytic tumors of the central nervous system using mutation analysis, copy number alterations, and DNA methylation profilingIn: Clinical Cancer Research Vol. 24 (2018) Nr. 18, pp. 4494 - 4504
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Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosaIn: Molecular Psychiatry Vol. 23 (2018) Nr. 5, pp. 1169 - 1180
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Longer Follow-Up Confirms Relapse-Free Survival Benefit With Adjuvant Dabrafenib Plus Trametinib in Patients With Resected BRAF V600–Mutant Stage III MelanomaIn: Journal of Clinical Oncology Vol. 36 (2018) Nr. 35, pp. 3441 - 3449
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Measurable residual disease-guided treatment with azacitidine to prevent haematological relapse in patients with myelodysplastic syndrome and acute myeloid leukaemia (RELAZA2) : an open-label, multicentre, phase 2 trialIn: The Lancet Oncology Vol. 19 (2018) Nr. 12, pp. 1668 - 1679
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Mycophenolate plus methylprednisolone versus methylprednisolone alone in active, moderate-to-severe Graves' orbitopathy (MINGO) : a randomised, observer-masked, multicentre trialIn: The Lancet Diabetes and Endocrinology Vol. 6 (2018) Nr. 4, pp. 287 - 298
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NAPOLI-1 phase III trial outcomes by prior surgery, and disease stage, in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC)In: Annals of Oncology: official journal of the European Society for Medical Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii249 - viii250
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Nanomaterial-microbe cross-talk : physicochemical principles and (patho)biological consequencesIn: Chemical Society Reviews Vol. 47 (2018) Nr. 14, pp. 5312 - 5337
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Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067) : 4-year outcomes of a multicentre, randomised, phase 3 trialIn: The Lancet Oncology Vol. 19 (2018) Nr. 11, pp. 1480 - 1492
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Notch-induced myeloid reprogramming in spontaneous pancreatic ductal adenocarcinoma by dual genetic targetingIn: Cancer Research Vol. 78 (2018) Nr. 17, pp. 4997 - 5010
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Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemiaIn: Nature Communications Vol. 9 (2018) pp. 3839
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Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathwaysIn: Nature Communications Vol. 9 (2018) Nr. 1, pp. 4774
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Overall survival at 4 years of follow-up in a phase III trial of nivolumab plus ipilimumab combination therapy in advanced melanoma (CheckMate 067)In: Annals of Oncology: official journal of the European Society for Medical Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii735
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Overall survival in patients with BRAF-mutant melanoma receiving encorafenib plus binimetinib versus vemurafenib or encorafenib (COLUMBUS) : a multicentre, open-label, randomised, phase 3 trialIn: The Lancet Oncology Vol. 19 (2018) Nr. 10, pp. 1315 - 1327
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Overall survival in patients with advanced melanoma who received nivolumab versus investigator's choice chemotherapy in CheckMate 037 : A Randomized, Controlled, Open-Label Phase III TrialIn: Journal of Clinical Oncology Vol. 36 (2018) Nr. 4, pp. 383 - 390
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PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinomaIn: The New England Journal of Medicine Vol. 379 (2018) Nr. 4, pp. 341 - 351
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PD-L1 and CD8 expression and association with outcomes in patients (pts) with BRAF V600E/K–mutant metastatic melanoma (MM) who received dabrafenib + trametinib (D+T) in the randomized phase 3 COMBI-v study.In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 5 Suppl., pp. 183
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Phosphatidylinositol 3-kinase a–selective inhibition with alpelisib (BYL719) in PIK3CA-altered solid tumors : Results from the first-in-human studyIn: Journal of Clinical Oncology Vol. 36 (2018) Nr. 13, pp. 1291 - 1299
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Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin Lymphomas (PETAL) : A Multicenter, Randomized Phase III TrialIn: Journal of Clinical Oncology Vol. 36 (2018) Nr. 20, pp. 2024 - 2034
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Prognostic value of baseline biliary stents on outcomes in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) in the NAPOLI-1 trialIn: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 5, pp. v42
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Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80.In: Molecular Cell Vol. 71 (2018) Nr. 6, pp. 923 - 939.e10
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Rogaratinib treatment of patients with advanced urothelial carcinomas prescreened for tumor FGFR mRNA expression.In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 6 Suppl., pp. 494
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Role of elevated PHIP copy number as a prognostic and progression marker for cutaneous melanomaIn: Clinical Cancer Research Vol. 24 (2018) Nr. 17, pp. 4119 - 4125
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Small Meets Smaller : Effects of Nanomaterials on Microbial Biology, Pathology, and EcologyIn: ACS Nano Vol. 12 (2018) Nr. 7, pp. 6351 - 6359
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Subgroup analysis by baseline pain intensity (BPI) and analgesic use (BAU) in NAPOLI-1 : A phase III study of liposomal irinotecan (nal IRI)+/- 5-fluorouracil/leucovorin (5-FU/LV) in patients (pts) with metastatic pancreatic ductal adenocarcinoma (mPDAC) pIn: Journal of Clinical Oncology Vol. 36 (2018) Nr. Suppl. 4, pp. 379
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Subgroup analysis by measurable metastatic lesion (ML) number and selected lesion locations (LL) at baseline (BL) in NAPOLI-1 : A phase III study of liposomal irinotecan (nal-IRI)+/- 5-fluorouracil/leucovorin (5-FU/LV) in patients (pts) with metastatic panIn: Journal of Clinical Oncology Vol. 36 (2018) Nr. Suppl. 4, pp. 460
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Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone lossIn: Nature Medicine Vol. 24 (2018) Nr. 5, pp. 667 - 678
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The effect of best response to prior anticancer therapy on efficacy outcomes in the NAPOLI-1 trial of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) previously treated with gemcitabine-based therapyIn: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 5, pp. v42
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Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccinationIn: Nature Communications Vol. 9 (2018) Nr. 1, pp. 1212
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UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteinsIn: Nature Communications Vol. 9 (2018) Nr. 1, pp. 484
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Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme FormationIn: Molecular Cell Vol. 72 (2018) Nr. 4, pp. 766 - 777
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Updated relapse-free survival (RFS) and biomarker analysis in the COMBI-AD trial of adjuvant dabrafenib + trametinib (D + T) in patients (pts) with resected BRAF V600-mutant stage III melanomaIn: Annals of Oncology: official journal of the European Society for Medical Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii734 - viii735
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Updated relapse-free survival (RFS) and biomarker analysis in the COMBI-AD trial of adjuvant dabrafenib plus trametinib (D plus T) in patients (pts) with resected BRAF V600-mutant stage III melanomaIn: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8,
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Value of Progression of Coronary Artery Calcification for Risk Prediction of Coronary and Cardiovascular Events : Result of the HNR Study (Heinz Nixdorf Recall)In: Circulation Vol. 137 (2018) Nr. 7, pp. 665 - 679
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