Welcome to ZMB

Welcome to ZMB

The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.

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News & Events

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Coronavirus: Current Information
(University of Duisburg-Essen)

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21.12.2020 Tumor researcher honored

Dr. Johann Matschke, young scientist at the Institute of Cell Biology (Tumor Research) was awarded the Dieter-Frankenberg-Nachwuchspreis of the German Society for Biological Radiation Research. He received the award, endowed with 2,000 euros, for his outstanding work on the elucidation of metabolic adaptation reactions with relevance for radiation resistance and potential for its therapeutic modulation.

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13.10.2020 PD Dr. Adalbert Krawczyk awarded

ZMB member virologist PD Dr. Adalbert Krawczyk has been awarded the Gottschalk-Diederich-Baedeker Prize 2020. This honors his outstanding achievements at the University Hospital Essen for research into the development of a highly effective antibody for the prevention and therapy of Herpex Simplex Virus (HSV) infections.

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New Heisenberg Professorship Interlocked molecules as catalysts

[02.12.2020] Not directly connected, but inseparable: Interlocked molecules are interwoven like links in a chain or like a ring on a thread. Dr. Jochen Niemeyer investigates how they are applied. The new Heisenberg professor for organic and supramolecular chemistry is particularly interested in their use as catalysts.

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Press Releases 2020/2021

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Cooperation UDE / Wuhan One of the most important publications on COVID-19

[18.01.2021] One of the world's most important publications on COVID-19 was written in cooperation with the medical faculty and scientific partners in Wuhan (China). It was published in April 2020 and describes important changes in the immune system of those affected. Eight months later, the relevance of the study becomes apparent: It is one of the most cited publications on the subject worldwide.

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Nationwide Network University Medicine Funding for COVID-19 research in Essen approved

[08.01.2021] Clinics and institutes of the University Hospital Essen that collect and analyze disease data and samples from COVID-19 patients are supported by the German Federal Ministry of Education and Research (BMBF) with 895,000€ until the end of this year. The joint goal of the researchers and clinicians is to formulate new research questions and answer existing ones.

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DFG funds immune cell study Covid-19: Better understanding of defense cells

[21.12.2020] In a study, researchers from the Faculty of Medicine are investigating the role played by certain immune cells in the fight against SARS-CoV-2 and why some of them last longer than others. Their findings could become particularly important for the treatment and vaccination of the population against COVID-19. The German Research Foundation (DFG) is funding the project for one year with 38,000 euros through a COVID-19 emergency program.

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Treatment of blood disorders Immune mechanism discovered

[03.12.2020] Researchers from the Medical Faculty of the UDE and the German Consortium for Translational Cancer Research (DKTK) at the partner location Essen/Düsseldorf have been able to explain a new mechanism in the human immune system. On the basis of their results, new approaches can be studied to improve the therapeutic success of blood stem cell transplants. The German-Dutch study was published in the renowned journal Blood.

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SARS-CoV-2 UV light inactivates corona viruses

[01.09.2020] SARS-CoV-2 viruses can be completely inactivated with ultraviolet light. This was shown of Virologyby a promising study by ZMB member PD Dr. Adalbert Krawczyk (photo) and Dr. Christiane Heilingloh from the Institute at the University Hospital Essen. The American Journal of Infection Control is now reporting on this. Their research was funded by the University Medicine Essen Foundation and the Rudolf Ackermann Foundation.

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DFG Research Grant for Virkramjeet Singh Feedback loops between gut microbes and immune cells may impact outcome after stroke

[10.06.2020] The DFG approved funding for an exciting new research project of Dr. Vikramjeet Singh that targets at exploring how the interaction with gut microbiota shapes the impact of neutrophils on ischemic brain injury. Singh is principal investigator at the Institute of Experimental Immunology and Imaging at the University Hospital Essen. Working as postdoc at the Institute for Stroke and Dementia Research at the LMU Medical Center, Singh and his colleagues identified a bidirectional communication along the brain–gut microbiota–immune axis and could show that the gut microbiota is a potentially central regulator of immune homeostasis.

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Erkenntnisse für Test und Impfstoffe Neue Details der Immunantwort bei Covid-19

[22.05.2020] Das menschliche Immunsystem reagiert auf mehr als nur das bisher fokussierte Virusprotein. Das ist bedeutend für Tests und mögliche Impfstoffe. Forschungsteams der Ruhr-Universität Bochum (RUB) und der Medizinischen Fakultät der UDE am Universitätsklinikums Essen haben herausgefunden, auf welche Teile des Sars-Cov-2-Virus das menschliche Immunsystem reagiert: Neben dem bisher fokussierten Spike-Protein können auch zwei weitere Proteine eine starke Immunantwort auslösen.

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Deutsch-chinesische Forschung Schwere COVID-19-Verläufe früh erkennen

[30.04.2020] Viele COVID-19-Erkrankungen verlaufen mild. Aber etwa zehn Prozent der Erkrankten entwickeln eine schwere Lungenentzündung und benötigen intensivmedizinische Versorgung. Um frühzeitig die richtigen therapeutischen Schritte einleiten zu können, ist es wichtig, potentiell gefährdete Patienten zu identifizieren. Gemeinsam mit chinesischen Kollegen am Wuhan Union Hospital haben Wissenschaftler des Instituts für Virologie der Medizinischen Fakultät der UDE festgestellt, dass die T-Zell-Population ein wichtiger Indikator ist. Diese Studie ist jetzt in The Lancet EBiomedicine online veröffentlicht.

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Schilddrüse beeinflusst Hirnleistung stärker als gedacht Gut fürs Gedächtnis

[17.04.2020] Schilddrüsenhormone fördern unmittelbar die Bildung von Nervenzellen im Lern- und Gedächtniszentrum des Gehirns. Das belegen Forschungen der Medizinischen Fakultät der UDE und der University of Edinburgh erstmals. Die Ergebnisse liefern neben wichtigen Grundlagenerkenntnissen auch neue Ansatzpunkte, wie die geistige Leistungsfähigkeit mithilfe der Medizin verbessert werden kann. Das renommierte Stem Cell Reports berichtet.

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  • Obermann, Mark; Nägel, Steffen; Ose, Claudia; Sonuc, Nilüfer; Scherag, Andre; Storch, Peter; Gaul, Charly; Böger, Andreas; Kraya, Torsten; Jansen, Jan-Peter; Straube, Andreas; Freilinger, Tobias; Kaube, Holger; Jürgens, Tim P; Diener, Hans Christoph; Katsarava, Zaza; Kleinschnitz, Christoph; Holle, Dagny
    Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache : A multicentre, double-blind, randomised controlled trial
    In: The Lancet Neurology Vol. 20 (2021) Nr. 1, pp. 29 - 37
    ISSN: 1474-4465; 1474-4422
  • Schuler, Martin
    Corrigendum to “Inhibiting fibroblast growth factor receptors in cancer – The next generation”
    In: Annals of Oncology Vol. 32 (2021) Nr. 1, pp. 126
    ISSN: 1569-8041; 0923-7534
  • Somasundaram, Rajasekharan; Connelly, Thomas; Choi, Robin; Choi, Hyeree; Samarkina, Anastasia; Li, Ling; Gregorio, Elizabeth; Chen, Yeqing; Thakur, Rohit; Abdel-Mohsen, Mohamed; Beqiri, Marilda; Kiernan, Meaghan; Perego, Michela; Wang, Fang; Xiao, Min; Brafford, Patricia; Yang, Xue; Xu, Xiaowei; Secreto, Anthony; Danet-Desnoyers, Gwenn; Traum, Daniel; Kaestner, Klaus H.; Huang, Alexander C.; Hristova, Denitsa; Wang, Joshua; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Ping-Chen, Fang; Zhou, Xiangyang; Gutierrez, Alexis; Rebecca, Vito W.; Vonteddu, Prashanthi; Dotiwala, Farokh; Bala, Shashi; Majumdar, Sonali; Dweep, Harsh; Wickramasinghe, Jayamanna; Kossenkov, Andrew V.; Reyes-Arbujas, Jorge; Santiago, Kenisha; Nguyen, Tran; Griss, Johannes; Keeney, Frederick; Hayden, James; Gavin, Brian J.; Weiner, David; Montaner, Luis J.; Liu, Qin; Peiffer, Lukas; Becker, Jürgen; Burton, Elizabeth M.; Davies, Michael A.; Tetzlaff, Michael T.; Muthumani, Kar; Wargo, Jennifer A.; Gabrilovich, Dmitry; Herlyn, Meenhard
    Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 346
    ISSN: 2041-1723
  • Singh, Priyanka; Pesenti, Marion E.; Maffini, Stefano; Carmignani, Sara; Hedtfeld, Marius; Petrovic, Arsen; Srinivasamani, Anupallavi; Bange, Tanja; Musacchio, Andrea
    BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis
    In: Molecular Cell Vol. 81 (2021) Nr. 1, pp. 67 - 87.e9
    ISSN: 1097-4164; 1097-2765

ZMB Research Programs

Oncology

The concept of this research program is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments.

Participating researchers from biology, experimental and clinical medicine study tumors as “biological systems" and so called “neo-organs”.

A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.

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Immunology, Infectious Diseases and Transplantation

The immune system responds to various pathogens including viruses and bacteria in different ways to prevent severe disease and persistence in the host. Many pathogens, however, have developed mechanisms to evade immune defence.

The molecular and cellular interactions of pathogens with the immune system are studied within this program.

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Molecular and Chemical Cell Biology

Molecular and chemical cell biology is an interdisciplinary research program connecting molecular cell biology and genetics with chemistry and structural biology. Scientists of the participating disciplines collaborate to advance the understanding of basic molecular mechanisms of important biological processes.

The analysis of regulation and deregulation of key pathways is linking basic biology with pathophysiology.

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    Journal articles

  • Chuang, Chen-Hua; Dorsch, Madeleine; Dujardin, Philip; Silas, Sukrit; Ueffing, Kristina; Hölken, Johanna M; Yang, Dian; Winslow, Monte M.; Grüner, Barbara M.
    Altered mitochondria functionality defines a metastatic cell state in lung cancer and creates an exploitable vulnerability
    In: Cancer Research Vol. 81 (2021) Nr. 3,
    ISSN: 0008-5472; 1538-7445
  • Singh, Priyanka; Pesenti, Marion E.; Maffini, Stefano; Carmignani, Sara; Hedtfeld, Marius; Petrovic, Arsen; Srinivasamani, Anupallavi; Bange, Tanja; Musacchio, Andrea
    BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis
    In: Molecular Cell Vol. 81 (2021) Nr. 1, pp. 67 - 87.e9
    ISSN: 1097-4164; 1097-2765
  • Piano, Valentina; Alex, Amal; Stege, Patricia; Maffini, Stefano; Stoppiello, Gerardo A.; Huis In'T Veld, Pim J.; Vetter, Ingrid R.; Musacchio, Andrea
    CDC20 assists its catalytic incorporation in the mitotic checkpoint complex
    In: Science Vol. 371 (2021) Nr. 6524, pp. 67 - 71
    ISSN: 1095-9203; 0036-8075
  • Schuler, Martin
    Corrigendum to “Inhibiting fibroblast growth factor receptors in cancer – The next generation”
    In: Annals of Oncology Vol. 32 (2021) Nr. 1, pp. 126
    ISSN: 1569-8041; 0923-7534
  • Kunzmann, Volker; Siveke, Jens; Algül, Hana; Goekkurt, Eray; Siegler, Gabriele; Martens, Uwe; Waldschmidt, Dirk; Pelzer, Uwe; Fuchs, Martin; Kullmann, Frank; Boeck, Stefan; Ettrich, Thomas J; Held, Swantje; Keller, Ralph; Klein, Ingo; Germer, Christoph-Thomas; Stein, Hubert; Friess, Helmut; Bahra, Marcus; Jakobs, Ralf; Hartlapp, Ingo; Heinemann, Volker; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators; Stahl, Michael; Mahlmann, Stefan
    Nab-paclitaxel plus gemcitabine versus nab-paclitaxel plus gemcitabine followed by FOLFIRINOX induction chemotherapy in locally advanced pancreatic cancer (NEOLAP-AIO-PAK-0113) : a multicentre, randomised, phase 2 trial
    In: The Lancet Gastroenterology & Hepatology Vol. 6 (2021) Nr. 2, pp. 128 - 138
    ISSN: 2468-1253
  • Heming, Michael; Li, Xiaolin; Räuber, Saskia; Mausberg, Anne K.; Börsch, Anna-Lena; Hartlehnert, Maike; Singhal, Arpita; Lu, I-Na; Fleischer, Michael; Szepanowski, Fabian; Witzke, Oliver; Brenner, Thorsten; Dittmer, Ulf; Yosef, Nir; Kleinschnitz, Christoph; Wiendl, Heinz; Stettner, Mark; Meyer zu Hörste, Gerd
    Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid
    In: Immunity Vol. 54 (2021) Nr. 1, pp. 164
    ISSN: 1097-4180; 1074-7613
  • Mueller, Franziska; Friese, Alexandra; Pathe, Claudio; da Silva, Richard Cardoso; Bravo Rodriguez, Kenny; Musacchio, Andrea; Bange, Tanja
    Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization
    In: Science Advances Vol. 7 (2021) Nr. 3, pp. eabc8590
    ISSN: 2375-2548
  • Obermann, Mark; Nägel, Steffen; Ose, Claudia; Sonuc, Nilüfer; Scherag, Andre; Storch, Peter; Gaul, Charly; Böger, Andreas; Kraya, Torsten; Jansen, Jan-Peter; Straube, Andreas; Freilinger, Tobias; Kaube, Holger; Jürgens, Tim P; Diener, Hans Christoph; Katsarava, Zaza; Kleinschnitz, Christoph; Holle, Dagny
    Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache : A multicentre, double-blind, randomised controlled trial
    In: The Lancet Neurology Vol. 20 (2021) Nr. 1, pp. 29 - 37
    ISSN: 1474-4465; 1474-4422
  • Lee, Jung-Hoon; Bollschweiler, Daniel; Schäfer, Tillman; Huber, Robert
    Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies
    In: Science Advances Vol. 7 (2021) Nr. 2, pp. eabd4413
    ISSN: 2375-2548
  • Somasundaram, Rajasekharan; Connelly, Thomas; Choi, Robin; Choi, Hyeree; Samarkina, Anastasia; Li, Ling; Gregorio, Elizabeth; Chen, Yeqing; Thakur, Rohit; Abdel-Mohsen, Mohamed; Beqiri, Marilda; Kiernan, Meaghan; Perego, Michela; Wang, Fang; Xiao, Min; Brafford, Patricia; Yang, Xue; Xu, Xiaowei; Secreto, Anthony; Danet-Desnoyers, Gwenn; Traum, Daniel; Kaestner, Klaus H.; Huang, Alexander C.; Hristova, Denitsa; Wang, Joshua; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Ping-Chen, Fang; Zhou, Xiangyang; Gutierrez, Alexis; Rebecca, Vito W.; Vonteddu, Prashanthi; Dotiwala, Farokh; Bala, Shashi; Majumdar, Sonali; Dweep, Harsh; Wickramasinghe, Jayamanna; Kossenkov, Andrew V.; Reyes-Arbujas, Jorge; Santiago, Kenisha; Nguyen, Tran; Griss, Johannes; Keeney, Frederick; Hayden, James; Gavin, Brian J.; Weiner, David; Montaner, Luis J.; Liu, Qin; Peiffer, Lukas; Becker, Jürgen; Burton, Elizabeth M.; Davies, Michael A.; Tetzlaff, Michael T.; Muthumani, Kar; Wargo, Jennifer A.; Gabrilovich, Dmitry; Herlyn, Meenhard
    Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 346
    ISSN: 2041-1723
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    Journal articles

  • Gigante, Alba; Sijbesma, Eline; Sánchez-Murcia, Pedro A.; Hu, Xiaoyu; Bier, David; Bäcker, Sandra; Knauer, Shirley; Gago, Federico; Ottmann, Christian; Schmuck, Carsten
    A Supramolecular Stabilizer of the 14-3-3ζ/ERα Protein-Protein Interaction with a Synergistic Mode of Action
    In: Angewandte Chemie International Edition Vol. 132 (2020) Nr. 13, pp. 5322 - 5325
    ISSN: 1521-3773; 1433-7851; 0570-0833
  • Dykun, Iryna; Mahabadi, Amir Abbas; Rassaf, Tienush
    A clinical perspective on the 2019 ESC/EAS guidelines for the management of dyslipidaemias: PCSK-9 inhibitors for all?
    In: European Heart Journal Vol. 41 (2020) Nr. 24, pp. 2331
    ISSN: 1522-9645
  • Shen, Lu; Kohlhaas, Martha; Enoki, Junichi; Meier, Roland; Schönenberger, Bernhard; Wohlgemuth, Roland; Kourist, Robert; Niemeyer, Felix; van Niekerk, David; Bräsen, Christopher; Niemeyer, Jochen; Snoep, Jacky; Siebers, Bettina
    A combined experimental and modelling approach for the Weimberg pathway optimisation
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 1098
    ISSN: 2041-1723
  • Lang, Judith; Bohn, Patrick; Bhat, Hilal; Jastrow, Holger; Walkenfort, Bernd; Cansiz, Feyza; Fink, Julian; Bauer, Michael; Olszewski, Dominik; Ramos-Nascimento, Ana; Duhan, Vikas; Friedrich, Sarah-Kim; Becker-Flegler, Katrin; Krawczyk, Adalbert; Edwards, Michael J.; Burchert, Andreas; Huber, Magdalena; Friebus-Kardash, Justa; Göthert, Joachim Rudolf; Hardt, Cornelia; Probst, Hans Christian; Schumacher, Fabian; Köhrer, Karl; Kleuser, Burkhard; Babiychuk, Eduard B.; Sodeik, Beate; Seibel, Jürgen; Greber, Urs F.; Lang, Philipp A.; Gulbins, Erich; Lang, Karl S.
    Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 1338
    ISSN: 2041-1723
  • Dummer, Reinhard; Brase, Jan C.; Garrett, James; Campbell, Catarina D.; Gasal, Eduard; Squires, Matthew; Gusenleitner, Daniel; Santinami, Mario; Atkinson, Victoria; Mandalà, Mario; Chiarion-Sileni, Vanna; Flaherty, Keith; Larkin, James; Robert, Caroline; Kefford, Richard; Kirkwood, John M.; Hauschild, Axel; Schadendorf, Dirk; Long, Georgina V.
    Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAFV⁶⁰⁰-mutant, stage III melanoma (COMBI-AD) : Exploratory biomarker analyses from a randomised, phase 3 trial
    In: The Lancet Oncology Vol. 21 (2020) Nr. 3, pp. 358 - 372
    ISSN: 1474-5488; 1470-2045
  • Zimmer, Lisa; Livingstone, Elisabeth; Hassel, Jessica C.; Fluck, Michael; Eigentler, Thomas; Loquai, Carmen; Haferkamp, Sebastian; Gutzmer, Ralf; Meier, Friedegund; Mohr, Peter; Hauschild, Axel; Schilling, Bastian; Menzer, Christian; Kieker, Felix; Dippel, Edgar; Rösch, Alexander; Simon, Jan-Christoph; Conrad, Beate; Körner, Silvia; Windemuth-Kieselbach, Christine; Schwarz, Leonora; Garbe, Claus; Becker, Jürgen C.; Schadendorf, Dirk; Berking, Carola; Herbst, Rudolf A.; Martens, Uwe M; Sell, Sabine; Stadler, Rudolf; Terheyden, Patrick; Utikal, Jochen
    Adjuvant nivolumab plus ipilimumab or nivolumab monotherapy versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED) : a randomised, double-blind, placebo-controlled, phase 2 trial
    In: The Lancet Vol. 395 (2020) Nr. 10236, pp. 1558 - 1568
    ISSN: 1474-547X; 0140-6736
  • Eggermont, Alexander M. M.; Kicinski, Michal; Blank, Christian U.; Mandala, Mario; Long, Georgina V.; Atkinson, Victoria; Dalle, Stéphane; Haydon, Andrew; Khattak, Adnan; Carlino, Matteo S.; Sandhu, Shahneen; Larkin, James; Puig, Susana; Ascierto, Paolo A.; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Di Giacomo, Anna Maria; Van Den Eertwegh, Alfonsus J. M.; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; Lorigan, Paul C.; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Van Akkooi, Alexander; Robert, Caroline; Suciu, Stefan
    Association between Immune-Related Adverse Events and Recurrence-Free Survival among Patients with Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo : A Secondary Analysis of a Randomized Clinical Trial
    In: JAMA Oncology Vol. 6 (2020) Nr. 4, pp. 519 - 527
    ISSN: 2374-2445; 2374-2437
  • Puzanov, Igor; Ribas, Antoni; Robert, Caroline; Schachter, Jacob; Nyakas, Marta; Daud, Adil; Arance, Ana; Carlino, Matteo S.; O'Day, Steven J.; Long, Georgina V.; Margolin, Kim A.; Dummer, Reinhard; Schadendorf, Dirk; Lutzky, Jose; Ascierto, Paolo A.; Tarhini, Ahmad; Lin, Jianxin; Mogg, Robin; Homet Moreno, Blanca; Ibrahim, Nageatte; Hamid, Omid
    Association of BRAF V600E/K Mutation Status and Prior BRAF/MEK Inhibition with Pembrolizumab Outcomes in Advanced Melanoma : Pooled Analysis of 3 Clinical Trials
    In: JAMA Oncology Vol. 6 (2020) Nr. 8, pp. 1256 - 1264
    ISSN: 2374-2445; 2374-2437
  • Liu, David; Schilling, Bastian; Liu, Derek; Sucker, Antje; Livingstone, Elisabeth; Jerby-Arnon, Livnat; Zimmer, Lisa; Gutzmer, Ralf; Satzger, Imke; Loquai, Carmen; Grabbe, Stephan; Vokes, Natalie; Margolis, Claire A.; Conway, Jake; He, Meng Xiao; Elmarakeby, Haitham; Dietlein, Felix; Miao, Diana; Tracy, Adam; Gogas, Helen; Goldinger, Simone M.; Utikal, Jochen; Blank, Christian U.; Rauschenberg, Ricarda; von Bubnoff, Dagmar; Krackhardt, Angela; Weide, Benjamin; Haferkamp, Sebastian; Kiecker, Felix; Izar, Ben; Garraway, Levi; Regev, Aviv; Flaherty, Keith; Paschen, Annette; Van Allen, Eliezer M.; Schadendorf, Dirk
    Author Correction: Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
    In: Nature Medicine Vol. 26 (2020) Nr. 7, pp. 1147
    ISSN: 1546-170X; 1078-8956
  • Küppers, Ralf; Schadendorf, Dirk
    Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 6232
    ISSN: 2041-1723
  • Cabrita, Rita; Lauss, Martin; Sanna, Adriana; Donia, Marco; Skaarup Larsen, Mathilde; Mitra, Shamik; Johansson, Iva; Phung, Bengt; Harbst, Katja; Vallon-Christersson, Johan; van Schoiack, Alison; Lövgren, Kristina; Warren, Sarah; Jirström, Karin; Olsson, Håkan; Pietras, Kristian; Ingvar, Christian; Isaksson, Karolin; Schadendorf, Dirk; Schmidt, Henrik; Bastholt, Lars; Carneiro, Ana; Wargo, Jennifer A.; Svane, Inge Marie; Jönsson, Göran
    Author Correction: Tertiary lymphoid structures improve immunotherapy and survival in melanoma
    In: Nature Vol. 580 (2020) Nr. 7801, pp. E1
    ISSN: 1476-4687; 0028-0836
  • Killinger, Kerstin; Böhm, Miriam; Steinbach, Philine; Hagemann, Götz; Blüggel, Mike; Jänen, Karolin; Hohoff, Simone; Bayer, Peter; Herzog, Franz; Westermann, Stefan
    Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeast
    In: The EMBO Journal Vol. 39 (2020) Nr. 14, pp. e102938
    ISSN: 1460-2075; 0261-4189
  • Heinrich, Michael C.; Jones, Robin L.; von Mehren, Margaret; Schöffski, Patrick; Serrano, César; Kang, Yoon-Koo; Cassier, Philippe A.; Mir, Olivier; Eskens, Ferry; Tap, William D.; Rutkowski, Piotr; Chawla, Sant P.; Trent, Jonathan; Tugnait, Meera; Evans, Erica K.; Lauz, Tamieka; Zhou, Teresa; Roche, Maria; Wolf, Beni B.; Bauer, Sebastian; George, Suzanne
    Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR) : A multicentre, open-label, phase 1 trial
    In: The Lancet Oncology Vol. 21 (2020) Nr. 7, pp. 935 - 946
    ISSN: 1474-5488; 1470-2045
  • Wang, Huichen; Perrault, Ange Ronel; Takeda, Yoshihiko; Qin, Wei; Wang, Hongyan; Iliakis, George
    Biochemical evidence for Ku-independent backup pathways of NHEJ
    In: Nucleic Acids Research Vol. 48 (2020) Nr. 9, pp. 5200
    ISSN: 1362-4962; 0301-5610; 0305-1048
  • Bengoa-Vergniory, Nora; Faggiani, Emilie; Ramos-Gonzalez, Paula; Kirkiz, Ecem; Connor-Robson, Natalie; Brown, Liam V.; Siddique, Ibrar; Li, Zizheng; Vingill, Siv; Cioroch, Milena; Cavaliere, Fabio; Threlfell, Sarah; Roberts, Bradley; Schrader, Thomas; Klärner, Frank-Gerrit; Cragg, Stephanie; Dehay, Benjamin; Bitan, Gal; Matute, Carlos; Bezard, Erwan; Wade-Martins, Richard
    CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4885
    ISSN: 2041-1723
  • Grüner, Barbara M.; Fendt, Sarah-Maria
    Cancer cells stock up in lymph vessels to survive
    In: Nature Vol. 585 (2020) Nr. 7823, pp. 36 - 37
    ISSN: 1476-4687; 0028-0836
  • Brenner, Ellen; Schörg, Barbara F.; Ahmetlić, Fatima; Wieder, Thomas; Hilke, Franz Joachim; Simon, Nadine; Schroeder, Christopher; Demidov, German; Riedel, Tanja; Fehrenbacher, Birgit; Schaller, Martin; Forschner, Andrea; Eigentler, Thomas; Niessner, Heike; Sinnberg, Tobias; Böhm, Katharina S.; Hömberg, Nadine; Braumüller, Heidi; Dauch, Daniel; Zwirner, Stefan; Zender, Lars; Sonanini, Dominik; Geishauser, Albert; Bauer, Jürgen; Eichner, Martin; Jarick, Katja J.; Beilhack, Andreas; Biskup, Saskia; Döcker, Dennis; Schadendorf, Dirk; Quintanilla-Martinez, Leticia; Pichler, Bernd J.; Kneilling, Manfred; Mocikat, Ralph; Röcken, Martin
    Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 1335
    ISSN: 2041-1723
  • Totzeck, Matthias; Siebermair, Johannes; Rassaf, Tienush; Rischpler, Christoph
    Cardiac fibroblast activation detected by positron emission tomography/computed tomography as a possible sign of cardiotoxicity
    In: European Heart Journal Vol. 41 (2020) Nr. 9, pp. 1060
    ISSN: 1522-9645; 0195-668X
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    In: JAMA Oncology (2020) in press
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  • Hermann, Dirk M.; Bassetti, Claudio L.; Marx, Ute; Audoli-Inthavong, Marie-Laure; Chabriat, Hugues
    Refining endpoints for stroke recovery trials
    In: The Lancet Neurology Vol. 19 (2020) Nr. 5, pp. 381 - 382
    ISSN: 1474-4465; 1474-4422
  • Küppers, Ralf; Schadendorf, Dirk
    Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4748
    ISSN: 2041-1723
  • Blay, Jean-Yves; Serrano, César; Heinrich, Michael C.; Zalcberg, John; Bauer, Sebastian; Gelderblom, Hans; Schöffski, Patrick; Jones, Robin L; Attia, Steven; D'Amato, Gina; Chi, Ping; Reichardt, Peter; Meade, Julie; Shi, Kelvin; Ruiz-Soto, Rodrigo; George, Suzanne; von Mehren, Margaret
    Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS) : a double-blind, randomised, placebo-controlled, phase 3 trial
    In: The Lancet Oncology Vol. 21 (2020) Nr. 7, pp. 923 - 934
    ISSN: 1474-5488; 1470-2045
  • Petersdorf, Effie W.; Bengtsson, Mats; De Santis, Dianne; Dubois, Valerie; Fleischhauer, Katharina; Gooley, Ted; Horowitz, Mary; Madrigal, J Alejandro; Malkki, Mari; McKallor, Caroline; Morishima, Yasuo; Oudshoorn, Machteld; Spellman, Stephen R.; Villard, Jean; Stevenson, Phil; Carrington, Mary
    Role of HLA-DP Expression in Graft-Versus-Host Disease After Unrelated Donor Transplantation
    In: Journal of Clinical Oncology Vol. 38 (2020) Nr. 24, pp. 2712 - 2718
    ISSN: 1527-7755; 0732-183X
  • Heichler, Christina; Scheibe, Kristina; Schmied, Anabel; Geppert, Carol I; Schmid, Benjamin; Wirtz, Stefan; Thoma, Oana-Maria; Kramer, Viktoria; Waldner, Maximilian J; Büttner, Christian; Farin, Henner; Pešić, Marina; Knieling, Ferdinand; Merkel, Susanne; Grüneboom, Anika; Gunzer, Matthias; Grützmann, Robert; Rose-John, Stefan; Koralov, Sergei; Kollias, George; Vieth, Michael; Hartmann, Arndt; Greten, Florian; Neurath, Markus F; Neufert, Clemens
    STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis
    In: Gut Vol. 69 (2020) Nr. 7, pp. 1269 - 1282
    ISSN: 0017-5749
  • Bazinet, Michel; Pântea, Victor; Placinta, Gheorghe; Moscalu, Iurie; Cebotarescu, Valentin; Cojuhari, Lilia; Jimbei, Pavlina; Iarovoi, Liviu; Smesnoi, Valentina; Musteata, Tatiana; Jucov, Alina; Dittmer, Ulf; Krawczyk, Adalbert; Vaillant, Andrew
    Safety and Efficacy of 48 Weeks REP 2139 or REP 2165, Tenofovir Disoproxil, and Pegylated Interferon Alfa-2a in Patients With Chronic HBV Infection Naïve to Nucleos(t)ide Therapy
    In: Gastroenterology Vol. 158 (2020) Nr. 8, pp. 2180 - 2194
    ISSN: 1528-0012; 0016-5085
  • Chabriat, Hugues; Bassetti, Claudio L; Marx, Ute; Audoli-Inthavong, Marie-Laure; Sors, Aurore; Lambert, Estelle; Wattez, Marine; Hermann, Dirk M.; Diener, Hans Christoph; Restore Brain Study Investigators
    Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke : A multicentre, double-blind, randomised, placebo-controlled trial
    In: The Lancet Neurology Vol. 19 (2020) Nr. 3, pp. 226 - 233
    ISSN: 1474-4465; 1474-4422
  • George, Suzanne; Heinrich, Michael C.; Zalcberg, John Raymond; Bauer, Sebastian; Gelderblom, Hans; Schoffski, Patrick; Serrano, Cesar; Jones, Robin L.; Attia, Steven; D'Amato, Gina Z.; Chi, Ping; Reichardt, Peter; Lacouture, Mario E.; Cha, Elva; Meade, Julie Nicole; Ruiz-Soto, Rodrigo; Blay, Jean-Yves; von Mehren, Margaret
    Safety profile of ripretinib, including impact of alopecia, and Palmar-Plantar Erythrodysesthesia Syndrome (PPES) on patient-reported outcomes (PROs), in ≥ fourth-line advanced gastrointestinal stromal tumors (GIST) : Analyses from INVICTUS
    In: Journal of Clinical Oncology Vol. 38 (2020) Nr. 15_Suppl., pp. 11539
    ISSN: 0732-183X; 1527-7755
  • Küppers, Ralf; Schadendorf, Dirk; PCAWG Tumour Subtypes and Clinical Translation; PCAWG Consortium
    Sex differences in oncogenic mutational processes
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4330
    ISSN: 2041-1723
  • Mladenov, Emil; Staudt, Christian; Soni, Aashish; Murmann-Konda, Tamara; Siemann-Loekes, Maria; Iliakis, George
    Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52
    In: Nucleic Acids Research Vol. 48 (2020) Nr. 4, pp. 1905 - 1924
    ISSN: 1362-4962; 0305-1048
  • Sijbesma, Eline; Visser, Emira; Plitzko, Kathrin; Thiel, Philipp; Milroy, Lech-Gustav; Kaiser, Markus; Brunsveld, Luc; Ottmann, Christian
    Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 3954
    ISSN: 2041-1723
  • Cabrita, Rita; Lauss, Martin; Sanna, Adriana; Donia, Marco; Larsen, Mathilde; Schadendorf, Dirk
    Tertiary lymphoid structures improve immunotherapy and survival in melanoma
    In: Nature Vol. 577 (2020) Nr. 7791, pp. 561 - 565
    ISSN: 0028-0836; 1476-4687
  • Schuler, Martin
    The quest for efficient trial designs in precision oncology
    In: The Lancet Oncology Vol. 21 (2020) Nr. 12, pp. 1539 - 1541
    ISSN: 1474-5488; 1470-2045
  • Bell, Steven E. J.; Charron, Gaëlle; Cortés, Emiliano; Kneipp, Janina; de la Chapelle, Marc Lamy; Langer, Judith; Procházka, Marek; Tran, Vi; Schlücker, Sebastian
    Towards Reliable and Quantitative Surface-Enhanced Raman Scattering (SERS) : From Key Parameters to Good Analytical Practice
    In: Angewandte Chemie International Edition Vol. 59 (2020) pp. 5454 - 5462
    ISSN: 1521-3773; 1433-7851
  • Gremke, Niklas; Polo, Pierfrancesco; Dort, Aaron; Schneikert, Jean; Elmshäuser, Sabrina; Brehm, Corinna; Klingmüller, Ursula; Schmitt, Anna; Reinhardt, Hans Christian; Timofeev, Oleg; Wanzel, Michael; Stiewe, Thorsten
    mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4684
    ISSN: 2041-1723
top

    Journal articles

  • Wang, Kun; Sybers, David; Maklad, Hassan Ramadan; Lemmens, Liesbeth; Lewyllie, Charlotte; Zhou, Xiaoxiao; Schult, Frank; Bräsen, Christopher; Siebers, Bettina; Valegård, Karin; Lindås, Ann-Christin; Peeters, Eveline
    A TetR-family transcription factor regulates fatty acid metabolism in the archaeal model organism Sulfolobus acidocaldarius
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1542
    ISSN: 2041-1723
  • Türeci, Özlem; Sahin, Ugur; Schulze-Bergkamen, Henning; Zvirbule, Zanete; Lordick, Florian; Koeberle, Dieter; Thuss-Patience, Peter C.; Ettrich, Thomas J.; Arnold, Dirk; Bassermann, Florian; Al-Batran, Salah Eddin; Wiechen, K.; Dhaene, Karl F. L.; Maurus, D.; Gold, M.; Huber, Christopher H.; Krivoshik, Andrew P.; Arozullah, A.; Park, J. W.; Schuler, Martin
    A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus : the MONO study
    In: Annals of Oncology Vol. 30 (2019) Nr. 9, pp. 1487 - 1495
    ISSN: 1569-8041; 0923-7534
  • Wülling, Manuela; Vortkamp, Andrea
    A newly discovered stem cell that keeps bones growing
    In: Nature Vol. 567 (2019) Nr. 7747, pp. 178 - 179
    ISSN: 0028-0836; 1476-4687
  • Taylor, Matthew H.; Gainor, Justin F.; Hu, Mimi I-Nan; Zhu, Viola Weijia; Lopes, Gilberto; Leboulleux, Sophie; Brose, Marcia S.; Schuler, Martin; Bowles, Daniel W.; Kim, Dong-Wan; Baik, Christina S; Garralda, Elena; Lin, Chia-Chi; Adkins, Douglas; Sarker, Debashis; Curigliano, Giuseppe; Zhang, Hui; Clifford, Corinne; Turner, Christopher D.; Subbiah, Vivek
    Activity and tolerability of BLU-667, a highly potent and selective RET inhibitor, in patients with advanced RET-altered thyroid cancers
    In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15_Suppl, pp. 6018
    ISSN: 0732-183X; 1527-7755
  • Juric, Dejan; Janku, Filip; Rodón, Jordi; Burris, Howard A.; Mayer, Ingrid A.; Schuler, Martin; Seggewiss-Bernhardt, Ruth; Gil-Martin, Marta; Middleton, Mark R.; Baselga, José; Bootle, Douglas; Demanse, David; Blumenstein, Lars; Schumacher, Karl; Huang, Alan; Quadt, Cornelia; Rugo, Hope S.
    Alpelisib Plus Fulvestrant in PIK3CA -Altered and PIK3CA -Wild-Type Estrogen Receptor-Positive Advanced Breast Cancer : A Phase 1b Clinical Trial
    In: JAMA Oncology Vol. 5 (2019) Nr. 2, pp. e184475
    ISSN: 2374-2445; 2374-2437
  • Lindahl, Lise M.; Willerslev-Olsen, Andreas; Gjerdrum, Lise M.R.; Nielsen, Pia R.; Blümel, Edda; Rittig, Anne H.; Celis, Pamela; Herpers, Bjorn; Becker, Jürgen; Stausbøl-Grøn, Birgitte; Wasik, Mariusz A.; Gluud, Maria; Fredholm, Simon; Buus, Terkild B.; Johansen, Claus; Nastasi, Claudia; Peiffer, Lukas; Kubat, Linda; Bzorek, Michael; Eriksen, Jens O.; Krejsgaard, Thorbjørn; Bonefeld, Charlotte M.; Geisler, Carsten; Mustelin, Tomas; Langhoff, Erik; Givskov, Michael; Woetmann, Anders; Kilian, Mogens; Litman, Thomas; Iversen, Lars; Odum, Niels
    Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma
    In: Blood Vol. 134 (2019) Nr. 13, pp. 1072 - 1083
    ISSN: 1528-0020; 0006-4971
  • Siemer, Svenja; Westmeier, Dana; Barz, Matthias; Eckrich, Jonas; Wünsch, Désirée; Seckert, Christof; Thyssen, Christian; Schilling, Oliver; Hasenberg, Mike; Pang, Chengfan; Docter, Dominic; Knauer, Shirley K.; Stauber, Roland H.; Strieth, Sebastian
    Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing : Implications for the design of improved nanoantibiotics
    In: Biomaterials Vol. 192 (2019) pp. 551 - 559
    ISSN: 0142-9612; 1878-5905
  • Mai, Elias K.; Hielscher, Thomas; Bertsch, Uta; Schlenzka, Jana; Salwender, Hans J.; Munder, Markus; Gerecke, Christian; Dührsen, Ulrich; Brossart, Peter; Neben, Kai; Hillengass, Jens; Raab, Marc S.; Merz, Maximilian; Baertsch, Marc-Andrea; Jauch, Anna; Hose, Dirk; Martin, Hans; Lindemann, Hans-Walter; Blau, Igor W.; Scheid, Christof; Weisel, Katja C.; Goldschmidt, Hartmut
    Bortezomib-based induction therapy with high or low-dose dexamethasone in newly diagnosed, transplant-eligible multiple myeloma
    In: Leukemia Vol. 33 (2019) Nr. 7, pp. 258 - 261
    ISSN: 0887-6924; 1476-5551
  • Dmitrieva-Posocco, Oxana; Dzutsev, Amiran; Posocco, David F.; Hou, Vivianty; Yuan, Wuxing; Thovarai, Vishal; Mufazalov, Ilgiz A.; Gunzer, Matthias; Shilovskiy, Igor P.; Khaitov, Musa R.; Trinchieri, Giorgio; Waisman, Ari; Grivennikov, Sergei I.
    Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer
    In: Immunity Vol. 50 (2019) Nr. 1, pp. 166 - 180.e7
    ISSN: 1097-4180; 1074-7613
  • Syeda, Mahrukh M; WIGGINS, JENNIFER M; Corless, Broderick; Long, Georgina V.; Flaherty, Keith; Schadendorf, Dirk; Nathan, Paul D.; Robert, Caroline; Ribas, Antoni; Davies, Michael A.; Grob, Jean Jacques; Gasal, Eduard; Squires, Matthew; Marker, Mahtab; Brase, Jan C.; Polsky, David
    Circulating tumor DNA (ctDNA) kinetics to predict survival in patients (pts) with unresectable or metastatic melanoma treated with dabrafenib (D) or D + trametinib (T)
    In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15_suppl, pp. 9510
    ISSN: 0732-183X; 1527-7755
  • Merz, Simon F.; Korste, Sebastian; Bornemann, Lea; Michel, Lars; Stock, Pia; Squire, Anthony; Soun, Camille; Engel, Daniel Robert; Detzer, Julia; Lörchner, Holger; Hermann, Dirk M.; Kamler, Markus; Klode, Joachim; Hendgen-Cotta, Ulrike B.; Rassaf, Tienush; Gunzer, Matthias; Totzeck, Matthias
    Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2312
    ISSN: 2041-1723
  • Smith, Nikaïa; Rodero, Mathieu P.; Bekaddour, Nassima; Bondet, Vincent; Ruiz-Blanco, Yasser B.; Harms, Mirja; Mayer, Benjamin; Badder-Meunier, Brigitte; Quartier, Pierre; Bodemer, Christine; Baudouin, Véronique; Dieudonné, Yannick; Kirchhoff, Frank; Sanchez-Garcia, Elsa; Charbit1, Bruno; Leboulanger, Nicolas; Jahrsdörfer, Bernd; Richard, Yolande; Korganow, Anne-Sophie; Münch, Jan; Nisole, Sébastien; Duffy, Darragh; Herbeuval, Jean-Philippe
    Control of TLR7-mediated type i IFN signaling in pDCs through CXCR4 engagement - A new target for lupus treatment
    In: Science Advances Vol. 5 (2019) Nr. 7, pp. eaav9019
    ISSN: 2375-2548
  • Quambusch, Lena; Landel, Ina; Depta, Laura; Weisner, Jörn; Uhlenbrock, Niklas; Müller, Matthias P.; Glanemann, Franziska; Althoff, Kristina; Siveke, Jens; Rauh, Daniel
    Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity
    In: Angewandte Chemie International Edition Vol. 58 (2019) Nr. 52, pp. 18823 - 18829
    ISSN: 1433-7851; 1521-3773
  • Rubio, Ignacio; Osuchowski, Marcin F; Shankar-Hari, Manu; Skirecki, Tomasz; Winkler, Martin Sebastian; Lachmann, Gunnar; La Rosée, Paul; Monneret, Guillaume; Venet, Fabienne; Bauer, Michael; Brunkhorst, Frank M; Kox, Matthijs; Cavaillon, Jean-Marc; Uhle, Florian; Weigand, Markus A; Flohe, Stefanie; Wiersinga, W Joost; Martin-Fernandez, Marta; Almansa, Raquel; Martin-Loeches, Ignacio; Torres, Antoni; Giamarellos-Bourboulis, Evangelos J; Girardis, Massimo; Cossarizza, Andrea; Netea, Mihai G; van der Poll, Tom; Scherag, Andre; Meisel, Christian; Schefold, Joerg C; Bermejo-Martín, Jesús F
    Current gaps in sepsis immunology: new opportunities for translational research
    In: The Lancet Infectious Diseases Vol. 19 (2019) Nr. 12, pp. e422 - e436
    ISSN: 1474-4457; 1473-3099
  • Vokes, Natalie; Margolis, Claire; Liu, David; Schilling, Bastian; Schadendorf, Dirk; Van Allen, Eliezer Mendel
    Distinct immunogenomic properties of melanomas with stable disease as best response to immune checkpoint blockade (ICB)
    In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 15_Suppl, pp. 2515 - 2515
    ISSN: 0732-183X; 1527-7755
  • Kurtz, David M.; Esfahani, Mohammad S.; Scherer, Florian; Soo, Joanne; Jin, Michael C.; Liu, Chih Long; Newman, Aaron M.; Dührsen, Ulrich; Hüttmann, Andreas; Casasnovas, Olivier; Westin, Jason R.; Ritgen, Matthais; Böttcher, Sebastian; Langerak, Anton W.; Roschewski, Mark; Wilson, Wyndham H.; Gaidano, Gianluca; Rossi, Davide; Bahlo, Jasmin; Hallek, Michael; Tibshirani, Robert; Diehn, Maximilian; Alizadeh, Ash A.
    Dynamic Risk Profiling Using Serial Tumor Biomarkers for Personalized Outcome Prediction
    In: Cell Vol. 178 (2019) Nr. 3, pp. 699 - 713.e19
    ISSN: 0092-8674; 1097-4172
  • Jackstadt, Rene; van Hooff, Sander R.; Leach, Joshua D.; Cortes-Lavaud, Xabier; Lohuis, Jeroen O.; Ridgway, Rachel A.; Wouters, Valérie M.; Roper, Jatin; Kendall, Timothy J.; Roxburgh, Campbell S.; Horgan, Paul G.; Nixon, Colin; Nourse, Craig; Gunzer, Matthias; Clark, William; Hedley, Ann; Yilmaz, Omer H.; Rashid, Mamunur; Bailey, Peter; Biankin, Andrew V.; Campbell, Andrew D.; Adams, David J.; Barry, Simon T.; Steele, Colin W.; Medema, Jan Paul; Sansom, Owen J.
    Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis
    In: Cancer Cell Vol. 36 (2019) Nr. 3, pp. 319 - 336.e7
    ISSN: 1535-6108
  • Lebbé, Celeste; Meyer, Nicolas; Mortier, Laurent; Marquez-Rodas, Ivan; Robert, Caroline; Rutkowski, Piotr; Menzies, Alexander M.; Eigentler, Thomas; Ascierto, Paolo A.; Smylie, Michael; Schadendorf, Dirk; Ajaz, Mazhar; Svane, Inge Marie; Gonzalez, Rene; Rollin, Linda; Lord-Bessen, Jennifer; Saci, Abdel; Grigoryeva, Elena; Pigozzo, Jacopo
    Evaluation of Two Dosing Regimens for Nivolumab in Combination With Ipilimumab in Patients With Advanced Melanoma : Results From the Phase IIIb/IV CheckMate 511 Trial
    In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 11, pp. 867 - 875
    ISSN: 0732-183X; 1527-7755
  • Silvestre-Roig, Carlos; Braster, Quinte; Wichapong, Kanin; Lee, Ernest Y.; Teulon, Jean Marie; Berrebeh, Nihel; Winter, Janine; Adrover, José M.; Santos, Giancarlo Santiago; Froese, Alexander; Lemnitzer, Patricia; Ortega-Gómez, Almudena; Chevre, Raphael; Marschner, Julian; Schumski, Ariane; Winter, Carla; Perez-Olivares, Laura; Pan, Chang; Paulin, Nicole; Schoufour, Tom; Hartwig, Helene; González-Ramos, Silvia; Kamp, Frits; Megens, Remco T. A.; Mowen, Kerri A.; Gunzer, Matthias; Maegdefessel, Lars; Hackeng, Tilman; Lutgens, Esther; Daemen, Mat; von Blume, Julia; Anders, Hans-Joachim; Nikolaev, Viacheslav O.; Pellequer, Jean-Luc; Weber, Christian; Hidalgo, Andrés; Nicolaes, Gerry A. F.; Wong, Gerard C. L.; Soehnlein, Oliver
    Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death
    In: Nature Vol. 569 (2019) Nr. 7755, pp. 236 - 240
    ISSN: 0028-0836; 1476-4687
  • Stepanova, Tatyana; Haefeli, Walter-Emil; Dittmer, Ulf; Ciesek, Sandra; Bremer, Birgit; Dandri, Maura; Burhenne, Jürgen; Voronkova, Natalia; Wedemeyer, Heiner; Alexandrov, Alexander; Urban, Stephan; Allweiss, Lena; Bogomolov, Pavel O.; Schöneweis, Katrin; Chulanov, Vladimir
    Final results of a multicenter, open-label phase 2 clinical trial (MYR203) to assess safety and efficacy of myrcludex B in cwith PEG-interferon Alpha 2a in patients with chronic HBV/HDV co-infection
    In: Journal of Hepatology Vol. 70 (2019) Nr. 1 Suppl., pp. e81
    ISSN: 0168-8278
  • Larkin, James; Chiarion-Sileni, Vanna; Gonzalez, Rene; Grob, Jean-Jacques; Rutkowski, Piotr; Lao, Christopher D.; Cowey, C Lance; Schadendorf, Dirk; Wagstaff, John; Dummer, Reinhard; Ferrucci, Pier F.; Smylie, Michael; Hogg, David; Hill, Andrew; Márquez-Rodas, Ivan; Haanen, John; Guidoboni, Massimo; Maio, Michele; Schöffski, Patrick; Carlino, Matteo S.; Lebbé, Céleste; McArthur, Grant; Ascierto, Paolo A.; Daniels, Gregory A.; Long, Georgina V.; Bastholt, Lars; Rizzo, Jasmine I.; Balogh, Agnes; Moshyk, Andriy; Hodi, F Stephen; Wolchok, Jedd D.
    Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
    In: The New England Journal of Medicine Vol. 381 (2019) Nr. 16, pp. 1535 - 1546
    ISSN: 1533-4406
  • Robert, C.; Grob, J.J.; Stroyakovskiy, D.; Karaszewska, B.; Hauschild, A.; Levchenko, E.; Chiarion Sileni, V.; Schachter, J.; Garbe, C.; Bondarenko, I.; Gogas, H.; Mandalá, M.; Haanen, J.B.A.G.; Lebbé, C.; MacKiewicz, A.; Rutkowski, P.; Nathan, P.D.; Ribas, A.; Davies, M.A.; Flaherty, K.T.; Burgess, P.; Tan, M.; Gasal, E.; Voi, M.; Schadendorf, Dirk; Long, G.V.; Grob, Jean J.; Haanen, John B.A.G.; Nathan, Paul D.; Davies, Michael A.; Flaherty, Keith T.; Long, Georgina V.
    Five-year outcomes with dabrafenib plus trametinib in metastatic melanoma
    In: The New England Journal of Medicine Vol. 381 (2019) Nr. 7, pp. 626 - 636
    ISSN: 1533-4406; 0028-4793
  • Dittmer, Ulf; Sutter, Kathrin; Kassiotis, George; Zelinskyy, Gennadiy; Bánki, Zoltán; Stoiber, Heribert; Santiago, Mario L.; Hasenkrug, Kim J.
    Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity
    In: FEMS Microbiology Reviews Vol. 43 (2019) Nr. 5, pp. 435 - 456
    ISSN: 1574-6976; 0168-6445
  • Watson, Hunna J.; Hinney, Anke; Giuranna, Johanna; Hebebrand, Johannes
    Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
    In: Nature Genetics Vol. 51 (2019) Nr. 8, pp. 1207 - 1214
    ISSN: 1061-4036; 1546-1718
  • Cheng, Shifeng; Xian, Wenfei; Fu, Yuan; Marin, Birger; Keller, Jean; Wu, Tian; Sun, Wenjing; Li, Xiuli; Xu, Yan; Zhang, Yu; Wittek, Sebastian; Reder, Tanja; Günther, Gerd; Gontcharov, Andrey; Wang, Sibo; Li, Linzhou; Liu, Xin; Wang, Jian; Yang, Huanming; Xu, Xun; Delaux, Pierre-Marc; Melkonian, Barbara; Wong, Gane Ka-Shu; Melkonian, Michael
    Genomes of Subaerial Zygnematophyceae Provide Insights into Land Plant Evolution
    In: Cell Vol. 179 (2019) Nr. 5, pp. 1057 - 1067.e14
    ISSN: 0092-8674; 0092-8674
  • Peters, Triinu; Hebebrand, Johannes; Hinney, Anke; Scherag, Andre; Depienne, C.
    Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms Across Eight Psychiatric Disorders
    In: Cell Vol. 179 (2019) Nr. 7, pp. 1469 - 1482.e11.
    ISSN: 0092-8674; 1097-4172
  • López, Cristina; Kleinheinz, Kortine; Aukema, Sietse M.; Rohde, Marius; Bernhart, Stephan H.; Hübschmann, Daniel; Wagener, Rabea; Toprak, Umut H.; Raimondi, Francesco; Kreuz, Markus; Waszak, Sebastian M.; Huang, Zhiqin; Sieverling, Lina; Paramasivam, Nagarajan; Seufert, Julian; Sungalee, Stephanie; Russell, Robert B.; Bausinger, Julia; Kretzmer, Helene; Ammerpohl, Ole; Bergmann, Anke K.; Binder, Hans; Borkhardt, Arndt; Brors, Benedikt; Claviez, Alexander; Doose, Gero; Feuerbach, Lars; Haake, Andrea; Hansmann, Martin-Leo; Hoell, Jessica; Hummel, Michael; Korbel, Jan O.; Lawerenz, Chris; Lenze, Dido; Radlwimmer, Bernhard; Richter, Julia; Rosenstiel, Philip; Rosenwald, Andreas; Schilhabel, Markus B.; Stein, Harald; Stilgenbauer, Stephan; Stadler, Peter F.; Szczepanowski, Monika; Weniger, Marc; Zapatka, Marc; Eils, Roland; Lichter, Peter; Loeffler, Markus; Möller, Peter; Trümper, Lorenz; Klapper, Wolfram; Wagner, Susanne; Richter, Gesine; Eils, Jürgen; Kerssemakers, Jules; Jaeger-Schmidt, Christina; Scholz, Ingrid; Borst, Christoph; Braulke, Friederike; Dreyling, Martin; Eberth, Sonja; Einsele, Hermann; Frickhofen, Norbert; Haas, Siegfried; Karsch, Dennis; Klepl, Nicole; Kneba, Michael; Lisfeld, Jasmin; Mantovani-Löffler, Luisa; Ott, German; Stadler, Christina; Staib, Peter; Zenz, Thorsten; Kube, Dieter; Kostezka, Ulrike; Binder, Vera; Leich, Ellen; Nagel, Inga; Pischimariov, Jordan; Schreiber, Stefan; Vater, Inga; Hopp, Lydia; Langenberger, David; Rosolowski, Maciej; Hoffmann, Steve; Küppers, Ralf; Burkhardt, Birgit; Schlesner, Matthias; Siebert, Reiner
    Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1459
    ISSN: 2041-1723
  • Buscaill, Pierre; Chandrasekar, Balakumaran; Sanguankiattichai, Nattapong; Kourelis, Jiorgos; Kaschani, Farnusch; Thomas, Emma L.; Morimoto, Kyoko; Kaiser, Markus; Preston, Gail M.; Ichinose, Yuki; Van Der Hoorn, Renier A.L.
    Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptides
    In: Science Vol. 364 (2019) Nr. 6436, pp. eaav0748
    ISSN: 1095-9203; 0036-8075
  • Emmons, Michael F.; Faião-Flores, Fernanda; Sharma, Ritin; Thapa, Ram; Messina, Jane L.; Becker, Jürgen; Schadendorf, Dirk; Seto, Edward; Sondak, Vernon K.; Koomen, John M.; Chen, Yian A.; Lau, Eric K.; Wan, Lixin; Licht, Jonathan D.; Smalley, Keiran S. M.
    HDAC8 regulates a stress response pathway in melanoma to mediate escape from BRAF inhibitor therapy
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    Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation
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    Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
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    MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma
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    MMP2/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearance
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    Machine learning-based predictors for immune checkpoint inhibitor therapy of non-small-cell lung cancer
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    Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing
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    Melanoma extracellular vesicles generate immunosuppressive myeloid cells by upregulating PD-L1 via TLR4 signaling
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    Microglial cell loss after ischemic stroke favors brain neutrophil accumulation
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    Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin
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    Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8⁺ T Cells and Evolve at the Population Level
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    Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF melanoma (PACMEL) : a multicentre, open-label, randomised, controlled phase II trial
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    Patient-reported outcomes in patients with resected, high-risk melanoma with BRAFV600E or BRAFV600K mutations treated with adjuvant dabrafenib plus trametinib (COMBI-AD) : a randomised, placebo-controlled, phase 3 trial
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    Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4) : a randomised, phase 2/3 trial
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    Positron Emission Tomography-Guided Treatment in Early-Stage Favorable Hodgkin Lymphoma : Final Results of the International, Randomized Phase III HD16 Trial by the German Hodgkin Study Group
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    Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer
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  • Schadendorf, Dirk; Melanoma GWAS Consortium
    Publisher Correction : Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
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    Publisher Correction: Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response
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    Publisher Correction: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
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    Quality of life (QoL) and symptom burden in patients (pts) with advanced melanoma during the treatment-free interval (TFI) after discontinuation of nivolumab (NIVO) or NIVO plus ipilimumab (IPI)
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    Randomized phase III trial of ibrutinib and rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in non–germinal center B-cell diffuse large B-cell lymphoma
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    Rapid, Quantitative, and Ultrasensitive Point-of-Care Testing : A Portable SERS Reader for Lateral Flow Assays in Clinical Chemistry
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    Reply to E. Hindié and K.R. Hess
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    Reply to J. Wang et al
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    Rogaratinib in patients with advanced cancers selected by FGFR mRNA expression : a phase 1 dose-escalation and dose-expansion study
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    Salvage therapy after failure from anti-PD-1 single agent treatment : A Study by the German ADOReg melanoma registry
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    Sites of high local frustration in DNA origami
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    Survival Outcomes in Patients with Previously Untreated BRAF Wild-Type Advanced Melanoma Treated with Nivolumab Therapy : Three-Year Follow-up of a Randomized Phase 3 Trial
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    The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban
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    The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage
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  • Schadendorf, Dirk; Livingstone, Elisabeth; Zimmer, Lisa
    Treatment in metastatic melanoma : Time to re-think
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    Understanding HDV and HBsAg kinetics during nucleic acid polymer REP 2139 mono-therapy in HBeAg-negative chronic HBV/HDV co-infected patients via mathematical modeling
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    Unstable TTTTA/TTTCA expansions in MARCH6 are associated with Familial Adult Myoclonic Epilepsy type 3
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    Viral escape contributes to the failure of hepatitis D virus-specific CD8+ T-cells and drives evolution of HDV
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    Weightlifting unmasks high-risk coronary anomaly
    In: European Heart Journal Vol. 40 (2019) Nr. 1, pp. 72
    ISSN: 0195-668X; 1522-9645
  • Sahin, Ugur; Tureci, Özlem; Manikhas, Georgy M.; Lordick, Florian; Rusyn, Andriy; Vynnychenko, Ihor; Dudov, Assen; Bazin, Igor; Bondarenko, Igor; Melichar, Bohuslav; Dhaene, Karl; Wiechen, Kai; Maurus, Daniel; Schuler, Martin; Al-Batran, Salah-Eddin
    Zolbetuximab combined with EOX as first-line therapy in advanced CLDN18.2+ gastric (G) and gastroesophageal junction (GEJ) adenocarcinoma : Updated results from the FAST trial.
    In: Journal of Clinical Oncology Vol. 37 (2019) Nr. 4_Suppl, pp. 16
    ISSN: 0732-183X; 1527-7755
  • Varaljai, R.; Wistuba-Hamprecht, K.; Seremet, T.; Diaz, JMS; Nsengimana, J.; Sucker, A.; Griewank, Klaus; Horn, Peter; von Neuhoff, N.; Shannan, B.; Chauvistre, H.; Vogel, FCE; Horn, S.; Becker, J. C.; Newton-Bishop, J.; Stang, Andreas; Neyns, B.; Weide, B.; Schadendorf, Dirk; Rösch, Alexander
    ctDNA as a noninvasive monitoring tool in metastatic melanoma
    In: Journal of Clinical Oncology Vol. 37 (2019) Nr. Suppl. 15, pp. 9548
    ISSN: 0732-183X; 1527-7755
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    Journal articles

  • Jerby-Arnon, Livnat; Shah, Parin; Cuoco, Michael S.; Rodman, Christopher; Su, Mei-Ju; Melms, Johannes C.; Leeson, Rachel; Kanodia, Abhay; Mei, Shaolin; Lin, Jia-Ren; Wang, Shu; Rabasha, Bokang; Liu, David; Zhang, Gao; Margolais, Claire; Ashenberg, Orr; Ott, Patrick A.; Buchbinder, Elizabeth I.; Haq, Rizwan; Hodi, F. Stephen; Boland, Genevieve M.; Sullivan, Ryan J.; Frederick, Dennie T.; Miao, Benchun; Moll, Tabea; Flaherty, Keith T.; Herlyn, Meenhard; Jenkins, Russell W.; Thummalapalli, Rohit; Kowalczyk, Monika S.; Cañadas, Israel; Schilling, Bastian; Cartwright, Adam N.R.; Luoma, Adrienne M.; Malu, Shruti; Hwu, Patrick; Bernatchez, Chantale; Forget, Marie-Andrée; Barbie, David A.; Shalek, Alex K.; Tirosh, Itay; Sorger, Peter K.; Wucherpfennig, Kai; Van Allen, Eliezer M.; Schadendorf, Dirk; Johnson, Bruce E.; Rotem, Asaf; Rozenblatt-Rosen, Orit; Garraway, Levi A.; Yoon, Charles H.; Izar, Benjamin; Regev, Aviv
    A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
    In: Cell Vol. 175 (2018) Nr. 4, pp. 984 - 997.e24
    ISSN: 1097-4172; 0092-8674
  • Pöhler, Robert; Krahn, Jan; van den Boom, Johannes; Dobrynin, Grzegorz; Kaschani, Farnusch; Eggenweiler, Hans-Michael; Zenke, Frank T.; Kaiser, Markus; Meyer, Hemmo
    A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases
    In: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 6, pp. 1576 - 1580
    ISSN: 1521-3773; 1433-7851; 0570-0833
  • Horsthemke, Bernhard
    A critical view on transgenerational epigenetic inheritance in humans
    In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 2973
    ISSN: 2041-1723
  • Díaz-Carballo, David; Saka, Sahitya; Klein, Jacqueline; Rennkamp, Tobias; Acikelli, Ali H.; Malak, Sascha; Jastrow, Holger; Wennemuth, Gunther; Tempfer, Clemens; Schmitz, Inge; Tannapfel, Andrea; Strumberg, Dirk
    A distinct oncogenerative multinucleated cancer cell serves as a source of stemness and tumor heterogeneity
    In: Cancer Research Vol. 78 (2018) Nr. 9, pp. 2318 - 2331
    ISSN: 0008-5472; 1538-7445
  • Ackermann, Sandra; Cartolano, Maria; Hero, Barbara; Welte, Anne; Kahlert, Yvonne; Roderwieser, Andrea; Bartenhagen, Christoph; Walter, Esther; Gecht, Judith; Kerschke, Laura; Volland, Ruth; Menon, Roopika; Heuckmann, Johannes M.; Gartlgruber, Moritz; Hartlieb, Sabine; Henrich, Kai-Oliver; Okonechnikov, Konstantin; Altmüller, Janine; Nürnberg, Peter; Lefever, Steve; De Wilde, Bram; Sand, Frederik; Ikram, Fakhera; Rosswog, Carolina; Fischer, Janina; Theissen, Jessica; Hertwig, Falk; Singhi, Aatur D.; Simon, Thorsten; Vogel, Wenzel; Perner, Sven; Krug, Barbara; Schmidt, Matthias; Rahmann, Sven; Achter, Viktor; Lang, Ulrich; Vokuhl, Christian; Ortmann, Monika; Büttner, Reinhard; Eggert, Angelika; Speleman, Frank; O’Sullivan, Roderick J.; Thomas, Roman K.; Berthold, Frank; Vandesompele, Jo; Schramm, Alexander; Westermann, Frank; Schulte, Johannes; Peifer, Martin; Fischer, Matthias
    A mechanistic classification of clinical phenotypes in neuroblastoma
    In: Science Vol. 362 (2018) Nr. 6419, pp. 1165 - 1170
    ISSN: 1095-9203; 0036-8075
  • Grob, Jean Jacques; Garbe, Claus; Ascierto, Paolo; Larkin, James; Dummer, Reinhard; Schadendorf, Dirk
    Adjuvant melanoma therapy with new drugs : should physicians continue to focus on metastatic disease or use it earlier in primary melanoma?
    In: The Lancet Oncology Vol. 19 (2018) Nr. 12, pp. e720 - e725
    ISSN: 1470-2045; 1474-5488
  • Eggermont, Alexander M.M.; Blank, Christian U.; Mandala, Mario; Long, Georgina V.; Atkinson, Victoria; Dalle, Stéphane; Haydon, Andrew; Lichinitser, Mikhail; Khattak, Adnan; Carlino, Matteo S.; Sandhu, Shahneen; Larkin, James; Puig, Susana; Ascierto, Paolo A.; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Maio, Michele; Van Den Eertwegh, Alfonsus J. M.; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; Lorigan, Paul; Ibrahim, Nageatte; Marreaud, Sandrine; Van Akkooi, Alexander C. J.; Suciu, Stefan; Robert, Caroline
    Adjuvant pembrolizumab versus placebo in resected stage III melanoma
    In: The New England Journal of Medicine Vol. 378 (2018) Nr. 19, pp. 1789 - 1801
    ISSN: 1533-4406; 0028-4793
  • Maio, Michele; Lewis, Karl; Demidov, Lev; Mandalà, Mario; Bondarenko, Igor; Ascierto, Paolo A; Herbert, Christopher; Mackiewicz, Andrzej; Rutkowski, Piotr; Guminski, Alexander; Goodman, Grant R; Simmons, Brian; Ye, Chenglin; Yan, Yibing; Schadendorf, Dirk; BRIM8 Investigators
    Adjuvant vemurafenib in resected, BRAF mutation-positive melanoma (BRIM8) : a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial
    In: The Lancet Oncology Vol. 19 (2018) Nr. 4, pp. 510 - 520
    ISSN: 1470-2045; 1474-5488
  • Atkinson, Victoria G.; Hauschild, Axel; Santinami, Mario; Mandala, Mario; Chiarion Sileni, Vanna; Larkin, James M. G.; Nyakas, Marta S.; Dutriaux, Caroline; Haydon, Andrew M. M.; Mortier, Laurent; Robert, Caroline; Schachter, Jacob M.; Schadendorf, Dirk; Feng, X.; Jong, Egbert de; Mookerjee, Bijoyesh P.; Kefford, Rick F.; Dummer, Reinhard G.; Kirkwood, John M.; Long, Georgina V.
    Adverse events (AEs) over time in patients (pts) treated with adjuvant dabrafenib plus trametinib (D + T) or placebo (Pbo) in the COMBI-AD trial
    In: Annals of Oncology: official journal of the European Society for Medical Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii446
    ISSN: 0923-7534; 1569-8041
  • Kugel, Curtis H.; Douglass, Stephen M.; Webster, Marie R.; Kaur, Amanpreet; Liu, Qin; Yin, Xiangfan; Weiss, Sarah A.; Darvishian, Farbod; Al-Rohil, Rami N.; Ndoye, Abibatou; Behera, Reeti; Alicea, Gretchen M.; Ecker, Brett L.; Fane, Mitchell; Allegrezza, Michael J.; Svoronos, Nikolaos; Kumar, Vinit; Wang, Daniel Y.; Somasundaram, Rajasekharan; Hu-Lieskovan, Siwen; Ozgun, Alpaslan; Herlyn, Meenhard; Conejo-Garcia, Jose R.; Gabrilovich, Dmitry; Stone, Erica L.; Nowicki, Theodore S.; Sosman, Jeffrey; Rai, Rajat; Carlino, Matteo S.; Long, Georgina V.; Marais, Richard; Ribas, Antoni; Eroglu, Zeynep; Davies, Michael A.; Schilling, Bastian; Schadendorf, Dirk; Xu, Wei; Amaravadi, Ravi K.; Menzies, Alexander M.; McQuade, Jennifer L.; Johnson, Douglas B.; Osman, Iman; Weeraratna, Ashani T.
    Age correlates with response to anti-PD1, reflecting age-related differences in intratumoral effector and regulatory T-Cell populations
    In: Clinical Cancer Research Vol. 24 (2018) Nr. 21, pp. 5347 - 5356
    ISSN: 1078-0432; 1557-3265
  • Lollies, Anna; Hartmann, Sylvia; Schneider, Markus; Bracht, Thilo; Weiß, A.L.; Arnolds, Judith; Klein-Hitpaß, Ludger; Sitek, Barbara; Hansmann, Martin Leo; Küppers, Ralf; Weniger, Marc
    An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma
    In: Leukemia Vol. 32 (2018) Nr. 1, pp. 92 - 101
    ISSN: 0887-6924; 1476-5551
  • Gulbins, Anne; Schumacher, Fabian; Becker, Katrin Anne; Wilker, Barbara; Soddemann, Matthias; Boldrin, Francesco; Müller, Christian P.; Edwards, Michael J.; Goodman, Michael; Caldwell, Charles C.; Kleuser, Burkhard; Kornhuber, Johannes; Szabo, Ildiko; Gulbins, Erich
    Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide
    In: Molecular Psychiatry Vol. 23 (2018) pp. 2324 - 2346
    ISSN: 1476-5578; 1359-4184
  • Gulbins, Anne; Schumacher, Fabian; Becker, Katrin Anne; Wilker, Barbara; Soddemann, Matthias; Boldrin, Francesco; Müller, Christian P.; Edwards, Michael J.; Goodman, Michael; Caldwell, Charles C.; Kleuser, Burkhard; Kornhuber, Johannes; Szabo, Ildiko; Gulbins, Erich
    Antidepressants regulate autophagy by targeting acid sphingomyelinase
    In: Molecular Psychiatry Vol. 23 (2018) Nr. 12, pp. 2251
    ISSN: 1359-4184; 1476-5578
  • McQuade, Jennifer L; Daniel, Carrie R; Hess, Kenneth R; Mak, Carmen; Wang, Daniel Y; Rai, Rajat R; Park, John J; Haydu, Lauren E; Spencer, Christine; Wongchenko, Matthew; Lane, Stephen; Lee, Dung-Yang; Kaper, Mathilde; McKean, Meredith; Beckermann, Kathryn E; Rubinstein, Samuel M; Rooney, Isabelle; Musib, Luna; Budha, Nageshwar; Hsu, Jessie; Nowicki, Theodore S; Avila, Alexandre; Haas, Tomas; Puligandla, Maneka; Lee, Sandra; Fang, Shenying; Wargo, Jennifer A; Gershenwald, Jeffrey E; Lee, Jeffrey E; Hwu, Patrick; Chapman, Paul B; Sosman, Jeffrey A; Schadendorf, Dirk; Grob, Jean-Jacques; Flaherty, Keith T; Walker, Dana; Yan, Yibing; McKenna, Edward; Legos, Jeffrey J; Carlino, Matteo S; Ribas, Antoni; Kirkwood, John M; Long, Georgina V; Johnson, Douglas B; Menzies, Alexander M; Davies, Michael A
    Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy : a retrospective, multicohort analysis
    In: The Lancet Oncology Vol. 19 (2018) Nr. 3, pp. 310 - 322
    ISSN: 1470-2045
  • Gröbner, Susanne N; Worst, Barbara C; Weischenfeldt, Joachim; Buchhalter, Ivo; Kleinheinz, Kortine; Rudneva, Vasilisa A; Johann, Pascal D; Balasubramanian, Gnana Prakash; Segura-Wang, Maia; Brabetz, Sebastian; Bender, Sebastian; Hutter, Barbara; Sturm, Dominik; Pfaff, Elke; Hübschmann, Daniel; Zipprich, Gideon; Heinold, Michael; Eils, Jürgen; Lawerenz, Christian; Erkek, Serap; Lambo, Sander; Waszak, Sebastian; Blattmann, Claudia; Borkhardt, Arndt; Kuhlen, Michaela; Eggert, Angelika; Fulda, Simone; Gessler, Manfred; Wegert, Jenny; Kappler, Roland; Baumhoer, Daniel; Burdach, Stefan; Kirschner-Schwabe, Renate; Kontny, Udo; Kulozik, Andreas E; Lohmann, Dietmar; Hettmer, Simone; Eckert, Cornelia; Bielack, Stefan; Nathrath, Michaela; Niemeyer, Charlotte; Richter, Günther H; Schulte, Johannes; Siebert, Reiner; Westermann, Frank; Molenaar, Jan J; Vassal, Gilles; Witt, Hendrik; Burkhardt, Birgit; Kratz, Christian P; Witt, Olaf; van Tilburg, Cornelis M; Kramm, Christof M; Fleischhack, Gudrun; Dirksen, Uta; Rutkowski, Stefan; Frühwald, Michael; von Hoff, Katja; Wolf, Stephan; Klingebiel, Thomas; Koscielniak, Ewa; Landgraf, Pablo; Koster, Jan; Resnick, Adam C; Zhang, Jinghui; Liu, Yanling; Zhou, Xin; Waanders, Angela J; Zwijnenburg, Danny A; Raman, Pichai; Brors, Benedikt; Weber, Ursula D; Northcott, Paul A; Pajtler, Kristian; Kool, Marcel; Piro, Rosario M; Korbel, Jan O; Schlesner, Matthias; Eils, Roland; Jones, David T W; Lichter, Peter; Chavez, Lukas; Zapatka, Marc; Pfister, Stefan M; ICGC PedBrain-Seq Project; ICGC MMML-Seq Project
    Author Correction : The landscape of genomic alterations across childhood cancers
    In: Nature Vol. 559 (2018) Nr. 7714, pp. E10
    ISSN: 0028-0836; 1476-4687
  • Tucci, Felicia A.; Kitanovski, Simo; Johansson, Patricia; Klein-Hitpaß, Ludger; Kahraman, Alisan; Dürig, Jan; Hoffmann, Daniel; Küppers, Ralf
    Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individuals
    In: Blood Vol. 131 (2018) Nr. 5, pp. 546 - 557
    ISSN: 1528-0020; 0006-4971
  • Goldschmidt, H.; Lokhorst, H.M.; Mai, E.K.; Van Der Holt, B.; Blau, I.W.; Zweegman, S.; Weisel, K.C.; Vellenga, E.; Pfreundschuh, M.; Kersten, M.J.; Scheid, C.; Croockewit, S.; Raymakers, R.; Hose, D.; Potamianou, A.; Jauch, A.; Hillengass, J.; Stevens-Kroef, M.; Raab, M.S.; Broijl, A.; Lindemann, H.W.; Bos, G.M.J.; Brossart, P.; Van Marwijk Kooy, M.; Ypma, P.; Dührsen, Ulrich; Schaafsma, R.M.; Bertsch, U.; Hielscher, T.; Jarari, Le; Salwender, H.J.; Sonneveld, P.
    Bortezomib before and after high-dose therapy in myeloma : Long-term results from the phase III HOVON-65/GMMG-HD4 trial
    In: Leukemia Vol. 32 (2018) Nr. 2, pp. 383 - 390
    ISSN: 1476-5551; 0887-6924
  • Khairnar, Vishal; Duhan, Vikas; Patil, Ashwini M.; Zhou, Fan; Bhat, Hilal; Thoens, Christine; Sharma, Piyush; Adomati, Tom; Friendrich, Sarah-Kim; Bezgovsek, Judith; Dreesen, Janine D.; Wennemuth, Gunther; Westendorf, Astrid; Zelinskyy, Gennadiy; Dittmer, Ulf; Hardt, Cornelia; Timm, Jörg; Göthert, Joachim Rudolf; Lang, Philipp A.; Singer, Bernhard B.; Lang, Karl S.
    CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infection
    In: Nature Communications Vol. 9 (2018) pp. 2561
    ISSN: 2041-1723
  • Shukla, Sachet A.; Bachireddy, Pavan; Schilling, Bastian; Galonska, Christina; Zhan, Qian; Bango, Clyde; Langer, Rupert; Lee, Patrick C.; Gusenleitner, Daniel; Keskin, Derin B.; Babadi, Mehrtash; Mohammad, Arman; Gnirke, Andreas; Clement, Kendell; Cartun, Zachary J.; Van Allen, Eliezer M.; Miao, Diana; Huang, Ying; Snyder, Alexandra; Merghoub, Taha; Wolchok, Jedd D.; Garraway, Levi A.; Meissner, Alexander; Weber, Jeffrey S.; Hacohen, Nir; Neuberg, Donna; Potts, Patrick R.; Murphy, George F.; Lian, Christine G.; Schadendorf, Dirk; Hodi, F. Stephen; Wu, Catherine J.
    Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade
    In: Cell Vol. 173 (2018) Nr. 3, pp. 624 - 633.e8
    ISSN: 1097-4172; 0092-8674
  • Trusch, Franziska; Loebach, Lars; Wawra, Stephan; Durward, Elaine; Wuensch, Andreas; Iberahim, Nurul Aqilah; De Bruijn, Irene; MacKenzie, Kevin; Willems, Ariane; Toloczko, Aleksandra; Diéguez-Uribeondo, Javier; Rasmussen, Tim; Schrader, Thomas; Bayer, Peter; Secombes, Chris J.; Van West, Pieter
    Cell entry of a host-targeting protein of oomycetes requires gp96
    In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 2347
    ISSN: 2041-1723
  • Fan, Kaiji; Ritter, Cathrin; Nghiem, Paul; Blom, Astrid; Verhaegen, Monique E.; Dlugosz, Andrzej; Ødum, Niels; Woetmann, Anders; Tothill, Richard W.; Hicks, Rodney J.; Sand, Michael; Schrama, David; Schadendorf, Dirk; Ugurel, Selma; Becker, Jürgen C.
    Circulating cell-free miR-375 as surrogate marker of tumor burden in Merkel cell carcinoma
    In: Clinical Cancer Research Vol. 24 (2018) Nr. 23, pp. 5873 - 5882
    ISSN: 1078-0432; 1557-3265
  • Kurtz, David M.; Scherer, Florian; Jin, Michael C.; Soo, Joanne; Craig, Alexander F.M.; Esfahani, Mohammad Shahrokh; Chabon, Jacob J.; Stehr, Henning; Liu, Chih Long; Tibshirani, Robert; Maeda, Lauren S.; Gupta, Neel K.; Khodadoust, Michael S.; Advani, Ranjana H.; Levy, Ronald; Newman, Aaron M.; Dührsen, Ulrich; Hüttmann, Andreas; Meignan, Michel; Casasnovas, René-Olivier; Westin, Jason R.; Roschewski, Mark; Wilson, Wyndham H.; Gaidano, Gianluca; Rossi, Davide; Diehn, Maximilian; Alizadeh, Ash A.
    Circulating tumor DNA measurements as early outcome predictors in diffuse large B-Cell lymphoma
    In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 28, pp. 2845 - 2853
    ISSN: 0732-183X; 1527-7755
  • Lang, Stephan; Bruderek, Kirsten; Kaspar, Cordelia; Höing, Benedikt; Kanaan, Oliver; Dominas, Nina; Hussain, Timon; Droege, Freya; Eyth, Christian; Hadaschik, Boris; Brandau, Sven
    Clinical Relevance and Suppressive Capacity of Human Myeloid-Derived Suppressor Cell Subsets
    In: Clinical Cancer Research Vol. 24 (2018) Nr. 19, pp. 4834 - 4844
    ISSN: 1078-0432; 1557-3265
  • ter Veer, Emil; van Rijssen, L. Bengt; Besselink, Marc G.; Mali, Rosa M. A.; Berlin, Jordan D.; Boeck, Stefan; Bonnetain, Franck; Chau, Ian; Conroy, Thierry; Van Cutsem, Eric; Deplanque, Gael; Friess, Helmut; Glimelius, Bengt; Goldstein, David; Herrmann, Richard; Labianca, Roberto; Van Laethem, Jean-Luc; Macarulla, Teresa; van der Meer, Jonathan H. M.; Neoptolemos, John P.; Okusaka, Takuji; O'Reilly, Eileen M.; Pelzer, Uwe; Philip, Philip A.; van der Poel, Marcel J.; Reni, Michele; Scheithauer, Werner; Siveke, Jens; Verslype, Chris; Busch, Olivier R.; Wilmink, Johanna W.; van Oijen, Martijn G. H.; van Laarhoven, Hanneke W. M.
    Consensus statement on mandatory measurements in pancreatic cancer trials (COMM-PACT) for systemic treatment of unresectable disease
    In: The Lancet Oncology Vol. 19 (2018) Nr. 3, pp. e151 - e160
    ISSN: 1470-2045; 1474-5488
  • Huckins, L.M.; Hatzikotoulas, K.; Southam, L.; Thornton, L.M.; Steinberg, J.; Aguilera-McKay, F.; Treasure, J.; Schmidt, U.; Gunasinghe, C.; Romero, A.; Curtis, C.; Rhodes, D.; Moens, J.; Kalsi, G.; Dempster, D.; Leung, R.; Keohane, A.; Burghardt, R.; Ehrlich, S.; Hebebrand, Johannes; Hinney, Anke; Ludolph, A.; Walton, E.; Deloukas, P.; Hofman, A.; Palotie, A.; Palta, P.; van Rooij, F.J.A.; Stirrups, K.; Adan, R.; Boni, C.; Cone, R.; Dedoussis, G.; van Furth, E.; Gonidakis, F.; Gorwood, P.; Hudson, J.; Kaprio, J.; Kas, M.; Keski-Rahonen, A.; Kiezebrink, K.; Knudsen, G-P; Maj, M.; Monteleone, A.M.; Monteleone, P.; Raevuori, A.H.; Reichborn-Kjennerud, T.; Tozzi, F.; Tsitsika, A.; van Elburg, A.; Collier, D.A.; Sullivan, P.F.; Breen, G.; Bulik, C.M.; Zeggini, E.
    Correction: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
    In: Molecular Psychiatry Vol. 23 (2018) Nr. 9, pp. 1
    ISSN: 1476-5578; 1359-4184
  • Gharun, Kourosh; Senges, Julia; Seidl, Maximilian; Lösslein, Anne; Kolter, Julia; Lohrmann, Florens; Fliegauf, Manfred; Elgizouli, Magdeldin; Alber, Marco; Vavra, Martina; Schachtrup, Kristina; Illert, Anna L; Gilleron, Martine; Kirschning, Carsten Jürgen; Triantafyllopoulou, Antigoni; Henneke, Philipp
    Corrigendum: Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells
    In: EMBO Reports Vol. 19 (2018) Nr. 12, pp. e47190
    ISSN: 1469-221X; 1469-3178
  • Küppers, Ralf; Stevenson, Freda K.
    Critical influences on the pathogenesis of follicular lymphoma
    In: Blood Vol. 131 (2018) Nr. 21, pp. 2297 - 2306
    ISSN: 1528-0020; 0006-4971
  • Capper, David; Jones, David T. W.; Sill, Martin; Hovestadt, Volker; Schrimpf, Daniel; Sturm, Dominik; Koelsche, Christian; Sahm, Felix; Chavez, Lukas; Reuss, David E.; Kratz, Annekathrin; Wefers, Annika K.; Huang, Kristin; Pajtler, Kristian; Schweizer, Leonille; Stichel, Damian; Olar, Adriana; Engel, Nils W.; Lindenberg, Kerstin; Harter, Patrick N.; Braczynski, Anne K.; Plate, Karl H.; Dohmen, Hildegard; Garvalov, Boyan K.; Coras, Roland; Hölsken, Annett; Hewer, Ekkehard; Bewerunge-Hudler, Melanie; Schick, Matthias; Fischer, Roger; Beschorner, Rudi; Schittenhelm, Jens; Staszewski, Ori; Wani, Khalida; Varlet, Pascale; Pages, Melanie; Temming, Petra; Lohmann, Dietmar; Selt, Florian; Witt, Hendrik; Milde, Till; Witt, Olaf; Aronica, Eleonora; Giangaspero, Felice; Rushing, Elisabeth; Scheurlen, Wolfram; Geisenberger, Christoph; Rodriguez, Fausto J.; Becker, Albert; Preusser, Matthias; Haberler, Christine; Bjerkvig, Rolf; Cryan, Jane; Farrell, Michael; Deckert, Martina; Hench, Jürgen; Frank, Stephan; Serrano, Jonathan; Kannan, Kasthuri; Tsirigos, Aristotelis; Brück, Wolfgang; Hofer, Silvia; Brehmer, Stefanie; Seiz-Rosenhagen, Marcel; Hänggi, Daniel; Hans, Volkmar; Rozsnoki, Stephanie; Hansford, Jordan R.; Kohlhof, Patricia; Kristensen, Bjarne W.; Lechner, Matt; Lopes, Beatriz; Mawrin, Christian; Ketter, Ralf; Kulozik, Andreas; Khatib, Ziad; Heppner, Frank; Koch, Arend; Jouvet, Anne; Keohane, Catherine; Mühleisen, Helmut; Mueller, Wolf; Pohl, Ute; Prinz, Marco; Benner, Axel; Zapatka, Marc; Gottardo, Nicholas G.; Driever, Pablo Hernáiz; Kramm, Christof M.; Müller, Hermann L.; Rutkowski, Stefan; Von Hoff, Katja; Frühwald, Michael C.; Gnekow, Astrid; Fleischhack, Gudrun; Tippelt, Stephan; Calaminus, Gabriele; Monoranu, Camelia-Maria; Perry, Arie; Jones, Chris; Jacques, Thomas S.; Radlwimmer, Bernhard; Gessi, Marco; Pietsch, Torsten; Schramm, Johannes; Schackert, Gabriele; Westphal, Manfred; Reifenberger, Guido; Wesseling, Pieter; Weller, Michael; Collins, Vincent Peter; Blümcke, Ingmar; Bendszus, Martin; Debus, Jürgen; Huang, Annie; Jabado, Nada; Northcott, Paul A.; Paulus, Werner; Gajjar, Amar; Robinson, Giles W.; Taylor, Michael D.; Jaunmuktane, Zane; Ryzhova, Marina; Platten, Michael; Unterberg, Andreas; Wick, Wolfgang; Karajannis, Matthias A.; Mittelbronn, Michel; Acker, Till; Hartmann, Christian; Aldape, Kenneth; Schüller, Ulrich; Buslei, Rolf; Lichter, Peter; Kool, Marcel; Herold-Mende, Christel; Ellison, David W.; Hasselblatt, Martin; Snuderl, Matija; Brandner, Sebastian; Korshunov, Andrey; Von Deimling, Andreas; Pfister, Stefan M.
    DNA methylation-based classification of central nervous system tumours
    In: Nature Vol. 555 (2018) Nr. 7697, pp. 469 - 474
    ISSN: 0028-0836; 1476-4687
  • Lee, K.; Bodoky, Gyorgy; Blanc, Jean Frédéric; Siveke, Jens; Macarulla Mercade, T.; Wang-Gillam, Andrew; Chen, L.; Mirakhur, Beloo; Chen, Jie; Jong, Floris A. de
    Decreased appetite (DA) at baseline impacts prognosis in the NAPOLI-1 phase 3 study in metastatic pancreatic ductal adenocarcinoma (mPDAC)
    In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 5, pp. v42 - v43
    ISSN: 0923-7534; 1569-8041
  • Bogner, Simon; Schmid, Kurt Werner; Metzenmacher, Martin; Hager, Thomas; Herrmann, Ken; Walter, Robert; Hegedues, Balazs; Herold, Thomas; Eberhardt, Wilfried; Reis, Henning; Goetz, Moritz; Mairinger, Fabian Dominik; Wiesweg, Marcel; Darwiche, Kaid; Aigner, Clemens; Schuler, Martin
    Development of predictors for PD-1/PD-L1-directed therapy of non-small cell lung cancer (NSCLC) by gene expression profiling of small diagnostic biopsies (DBX)
    In: Journal of Clinical Oncology Vol. 36 (2018) Nr. 15 Suppl., pp. e15121
    ISSN: 0732-183X; 1527-7755
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    Longer Follow-Up Confirms Relapse-Free Survival Benefit With Adjuvant Dabrafenib Plus Trametinib in Patients With Resected BRAF V600–Mutant Stage III Melanoma
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    Mycophenolate plus methylprednisolone versus methylprednisolone alone in active, moderate-to-severe Graves' orbitopathy (MINGO) : a randomised, observer-masked, multicentre trial
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    Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067) : 4-year outcomes of a multicentre, randomised, phase 3 trial
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    Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia
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    Overall survival at 4 years of follow-up in a phase III trial of nivolumab plus ipilimumab combination therapy in advanced melanoma (CheckMate 067)
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    Overall survival in patients with BRAF-mutant melanoma receiving encorafenib plus binimetinib versus vemurafenib or encorafenib (COLUMBUS) : a multicentre, open-label, randomised, phase 3 trial
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    Overall survival in patients with advanced melanoma who received nivolumab versus investigator's choice chemotherapy in CheckMate 037 : A Randomized, Controlled, Open-Label Phase III Trial
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    PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma
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    PD-L1 and CD8 expression and association with outcomes in patients (pts) with BRAF V600E/K–mutant metastatic melanoma (MM) who received dabrafenib + trametinib (D+T) in the randomized phase 3 COMBI-v study.
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    Phosphatidylinositol 3-kinase a–selective inhibition with alpelisib (BYL719) in PIK3CA-altered solid tumors : Results from the first-in-human study
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    Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin Lymphomas (PETAL) : A Multicenter, Randomized Phase III Trial
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    Prognostic value of baseline biliary stents on outcomes in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) in the NAPOLI-1 trial
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    Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80.
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    Rogaratinib treatment of patients with advanced urothelial carcinomas prescreened for tumor FGFR mRNA expression.
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