ZMB Member Karl Sebastian Lang

ZMB Member
Karl Sebastian Lang

Next ZMB-Member
portrait photo of ZMB member Karl Sebastian Lang
© Lang

Prof. Dr. Karl Sebastian Lang

Director of:

Institute of Immunology

University Hospital Essen
Hufelandstr. 55
45122 Essen

Research Overview

The group of Prof. Lang studies molecular and cellular immunological mechanisms which can influence the outcome of human disease. This includes immunopathology occurring during autoimmune disease, infectious disease, tumor disease and transplantation. Mainly immunological models are used for these studies.

The following models are currently used:

  • Lmphocytic choriomeningitis virus (LCMV)
  • Vesicular stomatitis Virus (VSV)
  • Listeria monocytogenes
  • RIP-GP model (Autoimmune diabetes)
  • B16 melanoma model
Read more

Selected Publications

    Journal articles

  • Liu, Wei; Stachura, Paweł; Xu, Haifeng C.; Váraljai, Renáta; Shinde, Prashant; Ganesh, Nikkitha Umesh; Mack, Matthias; Van Lierop, Anke; Huang, Anfei; Sundaram, Balamurugan; Lang, Karl S.; Picard, Daniel; Fischer, Ute; Remke, Marc; Homey, Bernhard; Rösch, Alexander; Häussinger, Dieter; Lang, Philipp A.; Borkhardt, Arndt; Pandyra, Aleksandra A.; Stachura, Pawel; Umesh Ganesh, Nikkitha
    BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment
    In: Cancer Research Vol. 82 (2022) Nr. 2, pp. 264 - 277
    Online Full Text: dx.doi.org/ (Open Access)
  • Cheung, Phyllis F.; Yang, JiaJin; Fang, Rui; Borgers, Arianna; Krengel, Kirsten; Stoffel, Anne; Althoff, Kristina; Yip, Chi Wai; Siu, Elaine H. L.; Ng, Linda W. C.; Lang, Karl S.; Cham, Lamin B.; Engel, Daniel Robert; Soun, Camille; Cima, Igor; Scheffler, Björn; Striefler, Jana K.; Sinn, Marianne; Bahra, Marcus; Pelzer, Uwe; Oettle, Helmut; Markus, Peter; Smeets, Esther M. M.; Aarntzen, Erik H. J. G.; Savvatakis, Konstantinos; Liffers, Sven-Thorsten; Lueong, Smiths S.; Neander, Christian; Bazarna, Anna; Zhang, Xin; Paschen, Annette; Crawford, Howard C.; Chan, Anthony W. H.; Cheung, Siu Tim; Siveke, Jens
    Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression
    In: Nature Communications Vol. 13 (2022) Nr. 1, 156
    Online Full Text: dx.doi.org/ (Open Access)
  • Cappello, Sabrina; Sung, Hsu-Min; Ickes, Christian; Gibhardt, Christine S.; Vultur, Adina; Bhat, Hilal; Hu, Zhongwen; Brafford, Patricia; Denger, Andreas; Stejerean-Todoran, Ioana; Köhn, Rixa-Mareike; Lorenz, Verena; Künzel, Nicolas; Salinas, Gabriela; Stanisz, Hedwig; Legler, Tobias; Rehling, Peter; Schön, Michael P.; Lang, Karl S.; Helms, Volkhard; Herlyn, Meenhard; Hoth, Markus; Kummerow, Carsten; Bogeski, Ivan
    Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies
    In: Cancer Research Vol. 81 (2021) Nr. 21, pp. 5540 - 5554
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Namineni, Sukumar; O'Connor, Tracy; Faure-Dupuy, Suzanne; Johansen, Pål; Riedl, Tobias; Liu, Kaijing; Xu, Haifeng; Singh, Indrabahadur; Shinde, Prashant; Li, Fanghui; Pandyra, Aleksandra; Sharma, Piyush; Ringelhan, Marc; Muschaweckh, Andreas; Borst, Katharina; Blank, Patrick; Lampl, Sandra; Neuhaus, Katharina; Durantel, David; Farhat, Rayan; Weber, Achim; Lenggenhager, Daniela; Kündig, Thomas M.; Staeheli, Peter; Protzer, Ulrike; Wohlleber, Dirk; Holzmann, Bernhard; Binder, Marco; Breuhahn, Kai; Assmus, Lisa Mareike; Nattermann, Jacob; Abdullah, Zeinab; Rolland, Maude; Dejardin, Emmanuel; Lang, Philipp A.; Lang, Karl S.; Karin, Michael; Lucifora, Julie; Kalinke, Ulrich; Knolle, Percy A.; Heikenwalder, Mathias
    A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control
    In: Journal of Hepatology Vol. 72 (2020) Nr. 5, pp. 960 - 975
    Online Full Text: dx.doi.org/ (Open Access)
  • Zhuang, Yuan; Xu, Haifeng C.; Shinde, Prashant V.; Warfsmann, Jens; Vasilevska, Jelena; Sundaram, Balamurugan; Behnke, Kristina; Huang, Jun; Hoell, Jessica I.; Borkhardt, Arndt; Pfeffer, Klaus; Taha, Mohamed S.; Herebian, Diran; Mayatepek, Ertan; Brenner, Dirk; Ahmadian, Mohammad Reza; Keitel, Verena; Wieczorek, Dagmar; Häussinger, Dieter; Pandyra, Aleksandra A.; Lang, Karl S.; Lang, Philipp A.
    Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury
    In: Gut Vol. 69 (2020) Nr. 1, pp. 133 - 145
    Online Full Text: dx.doi.org/ (Open Access)
  • Beyer, Marc; Abdullah, Zeinab; Chemnitz, Jens M.; Maisel, Daniela; Sander, Jil; Lehmann, Clara; Thabet, Yasser; Shinde, Prashant V.; Schmidleithner, Lisa; Köhne, Maren; Trebicka, Jonel; Schierwagen, Robert; Hofmann, Andrea; Popov, Alexey; Lang, Karl S.; Oxenius, Annette; Buch, Thorsten; Kurts, Christian; Heikenwalder, Mathias; Fätkenheuer, Gerd; Lang, Philipp A.; Hartmann, Pia; Knolle, Percy A.; Schultze, Joachim L.
    Publisher Correction: Tumor-necrosis factor impairs CD4⁺ T cell–mediated immunological control in chronic viral infection
    In: Nature Immunology Vol. 21 (2020) Nr. 9, pp. 1135
    Online Full Text: dx.doi.org/ (Open Access)
  • Behnke, Kristina; Zhuang, Yuan; Xu, Haifeng C.; Sundaram, Balamurugan; Reich, Maria; Shinde, Prashant V.; Huang, Jun; Modares, Nastaran Fazel; Tumanov, Alexei V.; Polz, Robin; Scheller, Jürgen; Ware, Carl F.; Pfeffer, Klaus; Keitel, Verena; Häussinger, Dieter; Pandyra, Aleksandra A.; Lang, Karl S.; Lang, Philipp A.
    Reply [Letter to the Editor: Characterization of CD169+ Macrophages in Liver Regeneration: Tissue Distribution and Fate?]
    In: Hepatology Vol. 70 (2019) Nr. 3, pp. 1074 - 1075
    Online Full Text: dx.doi.org/ (Open Access)
  • Behnke, Kristina; Zhuang, Yuan; Xu, Haifeng C.; Sundaram, Balamurugan; Reich, Maria; Shinde, Prashant V.; Huang, Jun; Modares, Nastaran Fazel; Tumanov, Alexei V.; Polz, Robin; Scheller, Jürgen; Ware, Carl F.; Pfeffer, Klaus; Keitel, Verena; Häussinger, Dieter; Pandyra, Aleksandra A.; Lang, Karl S.; Lang, Philipp A.
    B Cell-Mediated Maintenance of Cluster of Differentiation 169–Positive Cells Is Critical for Liver Regeneration
    In: Hepatology Vol. 68 (2018) Nr. 6, pp. 2348 - 2361
    Online Full Text: dx.doi.org/ (Open Access)
  • Khairnar, Vishal; Duhan, Vikas; Patil, Ashwini M.; Zhou, Fan; Bhat, Hilal; Thoens, Christine; Sharma, Piyush; Adomati, Tom; Friendrich, Sarah-Kim; Bezgovsek, Judith; Dreesen, Janine D.; Wennemuth, Gunther; Westendorf, Astrid; Zelinskyy, Gennadiy; Dittmer, Ulf; Hardt, Cornelia; Timm, Jörg; Göthert, Joachim Rudolf; Lang, Philipp A.; Singer, Bernhard B.; Lang, Karl S.
    CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infection
    In: Nature Communications Vol. 9 (2018) 2561
    Online Full Text: dx.doi.org/ (Open Access)
  • Horst, Andrea Kristina; Wegscheid, Claudia; Schaefers, Christoph; Schiller, Birgit; Neumann, Katrin; Lunemann, Sebastian; Langeneckert, Annika E; Oldhafer, Karl J; Weiler-Normann, Christina; Lang, Karl S.; Singer, Bernhard B.; Altfeld, Marcus; Diehl, Linda; Tiegs, Gisa
    Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice
    In: Hepatology Vol. 68 (2018) Nr. 1, pp. 200 - 214
    Online Full Text: dx.doi.org/
  • Kalkavan, Halime; Sharma, Piyush; Kasper, Stefan; Helfrich, Iris; Pandyra, Aleksandra A.; Gassa, Asmae; Virchow, Isabel; Flatz, Lukas; Brandenburg, Tim; Namineni, Sukumar; Heikenwalder, Mathias; Höchst, Bastian; Knolle, Percy A.; Wollmann, Guido; Von Laer, Dorothee; Drexler, Ingo; Rathbun, Jessica; Cannon, Paula M.; Scheu, Stefanie; Bauer, Jens; Chauhan, Jagat; Häussinger, Dieter; Willimsky, Gerald; Löhning, Max; Schadendorf, Dirk; Brandau, Sven; Schuler, Martin; Lang, Philipp A.; Lang, Karl S.
    Spatiotemporally restricted arenavirus replication induces immune surveillance and type i interferon-dependent tumour regression
    In: Nature Communications Vol. 8 (2017) pp. 14447
    Online Full Text: dx.doi.org/ (Open Access)
  • Beyer, Marc; Abdullah, Zeinab; Chemnitz, Jens M; Maisel, Daniela; Sander, Jil; Lehmann, Clara; Thabet, Yasser; Shinde, Prashant V; Schmidleithner, Lisa; Köhne, Maren; Trebicka, Jonel; Schierwagen, Robert; Hofmann, Andrea; Popov, Alexey; Lang, Karl S.; Oxenius, Annette; Buch, Thorsten; Kurts, Christian; Heikenwalder, Mathias; Fätkenheuer, Gerd; Lang, Philipp A; Hartmann, Pia; Knolle, Percy A; Schultze, Joachim L
    Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection
    In: Nature Immunology Vol. 17 (2016) Nr. 5, pp. 593 - 603
    Online Full Text: dx.doi.org/
  • Khairnar, Vishal; Duhan, Vikas; Lang, Karl S.
    CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production
    In: Nature Communications (2015) Nr. 6, pp. 6217
    Online Full Text: dx.doi.org/ (Open Access)
  • Lang, Elisabeth; Gatidis, Sergios; Freise, Noemi F; Bock, Hans; Kubitz, Ralf; Lauermann, Christian; Orth, Hans Martin; Klindt, Caroline; Schuier, Maximilian; Keitel, Verena; Reich, Maria; Liu, Guilai; Schmidt, Sebastian; Xu, Haifeng C; Qadri, Syed M; Herebian, Diran; Pandyra, Aleksandra A; Mayatepek, Ertan; Gulbins, Erich; Lang, Florian; Häussinger, Dieter; Lang, Karl S.; Föller, Michael; Lang, Philipp A
    Conjugated Bilirubin Triggers Anemia by Inducing Erythrocyte Death
    In: Hepatology Vol. 61 (2015) Nr. 1, pp. 275 - 284
    Online Full Text: dx.doi.org/ (Open Access)
  • Pandyra, Aleksandra; Mullen, Peter J.; Kalkat, Manpreet; Yu, Rosemary; Pong, Janice T.; Li, Zhihua; Trudel, Suzanne; Lang, Karl S.; Minden, Marc D.; Schimmer, Aaron D.; Penn, Linda
    Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop
    In: Cancer Research Vol. 74 (2014) Nr. 17, pp. 4772 - 4782
    Online Full Text: dx.doi.org/
  • Nguyen, X. H.; Fattakhova, G.; Lang, P. A.; Lang, Karl S.; Adam, D.; Föger, N.; Lee, K. H.
    Antiapoptotic function of Toso (Faim3) in death receptor signaling
    In: Blood Vol. 119 (2012) Nr. 7, pp. 1790 - 1791
    Online Full Text: dx.doi.org/
  • Recher, Mike; Burns, Siobhan O.; De La Fuente, Miguel A.; Volpi, Stefano; Dahlberg, Carin; Walter, Jolan E.; Moffitt, Kristin; Mathew, Divij; Honke, Nadine; Lang, Philipp A.; Patrizi, Laura; Falet, Hervé; Keszei, Marton; Mizui, Masayuki; Csizmadia, Eva; Candotti, Fabio; Nadeau, Kari; Bouma, Gerben; Delmonte, Ottavia M.; Frugoni, Francesco; Ferraz Fomin, Angela B.; Buchbinder, David; Lundequist, Emma Maria; Massaad, Michel J.; Tsokos, George C.; Hartwig, John; Manis, John; Terhorst, Cox; Geha, Raif S.; Snapper, Scott; Lang, Karl S.; Malley, Richard; Westerberg, Lisa; Thrasher, Adrian J.; Notarangelo, Luigi D.
    B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice
    In: Blood Vol. 119 (2012) Nr. 12, pp. 2819 - 2828
    Online Full Text: dx.doi.org/
  • Honke, Nadine; Shaabani, Namir; Cadeddu, Giuseppe; Sorg, Ursula R.; Zhang, Dong-Er; Trilling, Mirko; Klingel, Karin; Sauter, Martina; Kandolf, Reinhard; Gailus, Nicole; Van Rooijen, Nico; Burkart, Christoph; Baldus, Stephan E.; Grusdat, Melanie; Löhning, Max; Hengel, Hartmut; Pfeffer, Klaus; Tanaka, Masato; Häussinger, Dieter; Recher, Mike; Lang, Philipp A.; Lang, Karl S.
    Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus
    In: Nature Immunology Vol. 13 (2012) Nr. 1, pp. 51 - 57
    Online Full Text: dx.doi.org/
  • McIlwain, David R.; Lang, Philipp A.; Maretzky, Thorsten; Hamada, Koichi; Ohishi, Kazuhito; Maney, Sathish Kumar; Berger, Thorsten; Murthy, Aditya; Duncan, Gordon; Xu, Haifeng C.; Lang, Karl S.; Häussinger, Dieter; Wakeham, Andrew; Itie-Youten, Annick; Khokha, Rama; Ohashi, Pamela S.; Blobel, Carl P.; Mak, Tak W.
    iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS
    In: Science Vol. 335 (2012) Nr. 6065, pp. 229 - 232
    Online Full Text: dx.doi.org/
  • Pellegrini, M.; Calzascia, T.; Toe, J. G.; Preston, S. P.; Lin, A. E.; Elford, A. R.; Shahinian, A.; Lang, P. A.; Lang, Karl S.; Morre, M.; Assouline, B.; Lahl, K.; Sparwasser, T.; Tedder, T. F.; Paik, J. H.; DePinho, R. A.; Basta, S.; Ohashi, P. S.; Mak, T. W.
    IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology
    In: Cell Vol. 144 (2011) Nr. 4, pp. 601 - 613
    Online Full Text: dx.doi.org/ (Open Access)
  • Nguyen, X. H.; Lang, P. A.; Lang, Karl S.; Adam, D.; Fattakhova, G.; Föger, N.; Kamal, M. A.; Prilla, P.; Mathieu, S.; Wagner, C.; Mak, T.; Chan, A. C.; Lee, K. H.
    Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination
    In: Blood Vol. 118 (2011) Nr. 3, pp. 598 - 608
    Online Full Text: dx.doi.org/