ZMB Member Markus Kaiser
ZMB Member
Markus Kaiser
Next ZMB-Member
Prof. Dr. Markus Kaiser
Group
Chemical BiologyCenter of Medical Biotechnology (ZMB)
Faculty of Biology
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen
- +49 201 183 4980
- Website
- Selected Publications
- Publication Metrics
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- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
The Kaiser group develops and uses chemical biology approaches to investigate diverse aspects of regulated proteolysis and to study the molecular mechanisms behind bioactive small molecule action. Our interests are however not limited to basic research; rather, we aim to capitalize on our scientific findings for drug discovery or other medicinal applications.
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Selected Publications
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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survivalIn: Cell Vol. 186 (2023) Nr. 10, pp. 2176 - 2192.e22ISSN: 0092-8674; 1097-4172Online Full Text: dx.doi.org/ (Open Access)
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The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPaseIn: Nature Communications Vol. 14 (2023) Nr. 1,ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access)
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BacPROTACs mediate targeted protein degradation in bacteriaIn: Cell Vol. 185 (2022) Nr. 13, pp. 2338 - 2353.e18ISSN: 0092-8674; 1097-4172Online Full Text: dx.doi.org/ (Open Access)
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Chemoproteomics‐Enabled Identification of 4‐Oxo‐β‐Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9In: Angewandte Chemie International Edition Vol. 61 (2022) Nr. 47,ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/ (Open Access)
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Persister state-directed transitioning and vulnerability in melanomaIn: Nature Communications Vol. 13 (2022) Nr. 1,ISSN: 2041-1723Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactionsIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 3954ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access)
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A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPasesIn: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 6, pp. 1576 - 1580ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/
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An apoplastic peptide activates salicylic acid signalling in maizeIn: Nature Plants Vol. 4 (2018) Nr. 3, pp. 172 - 180ISSN: 2055-0278; 2055-026XOnline Full Text: dx.doi.org/ Online Full Text (Open Access)
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Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme FormationIn: Molecular Cell Vol. 72 (2018) Nr. 4, pp. 766 - 777ISSN: 1097-2765; 1097-4164Online Full Text: dx.doi.org/ (Open Access)
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Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic ArchaeaIn: Nature Communications Vol. 8 (2017) pp. 15352ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access)
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Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease InhibitorsIn: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 29, Special Issue: 100th Anniversary of the Royal Australian Chemical Institute, pp. 8555 - 8558ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/
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VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break RepairIn: Molecular Cell Vol. 64 (2016) Nr. 1, pp. 189 - 198ISSN: 1097-2765; 1097-4164Online Full Text: dx.doi.org/ (Open Access)
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Determinants of amyloid fibril degradation by the PDZ protease HTRA1In: Nature Chemical Biology Vol. 11 (2015) Nr. 11, pp. 862 - 869ISSN: 1552-4469; 1552-4450Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thalianaIn: Nature Chemical Biology Vol. 10 (2014) Nr. 10, pp. 830 - 836ISSN: 1552-4469; 1552-4450Online Full Text: dx.doi.org/
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Streamlining chemical probe discovery : libraries of "fully functionalized" small molecules for phenotypic screeningIn: Angewandte Chemie International Edition Vol. 52 (2013) Nr. 5, pp. 1368 - 1370ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/
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Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenasesIn: Angewandte Chemie International Edition Vol. 51 (2012) Nr. 21, pp. 5230 - 5233ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/
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Small-molecule stabilization of protein-protein interactions : An underestimated concept in drug discovery?In: Angewandte Chemie International Edition Vol. 51 (2012) Nr. 9, pp. 2012 - 2018ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/
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HTRA proteases : regulated proteolysis in protein quality controlIn: Nature Reviews Molecular Cell Biology Vol. 12 (2011) Nr. 3, pp. 152 - 162ISSN: 1471-0072Online Full Text: dx.doi.org/
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A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-PyronesIn: Angewandte Chemie International Edition Vol. 49 (2010) Nr. 21, pp. 3666 - 3670ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/
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The ras pathway modulator melophlin a targets dynaminsIn: Angewandte Chemie International Edition Vol. 48 (2009) Nr. 39, pp. 7240 - 7245ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/
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A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanismIn: Nature Vol. 452 (2008) pp. 755 - 758ISSN: 0028-0836; 1476-4687
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Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality controlIn: Angewandte Chemie International Edition Vol. 47 (2008) Nr. 7, pp. 1332 - 1334ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/
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Discovery of a New Class of Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B by Biology-Oriented SynthesisIn: Angewandte Chemie International Edition Vol. 47 (2008) Nr. 32, pp. 5973 - 5977ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/
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β-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.In: Nature Chemical Biology Vol. 4 (2008) Nr. 9, pp. 557 - 563ISSN: 1552-4469; 1552-4450
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The Core Structure of TMC-95A Is a Promising Lead for Reversible Proteasome InhibitionIn: Angewandte Chemie International Edition Vol. 41 (2002) Nr. 5, pp. 780 - 783ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/