ZMB Member Markus Kaiser

ZMB Member
Markus Kaiser

Next ZMB-Member
portrait photo of ZMB member Markus Kaiser
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Prof. Dr. Markus Kaiser

Group

Chemical Biology

Center of Medical Biotechhnology
Faculty of Biology
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

Research Overview

The Kaiser group develops and uses chemical biology approaches to investigate diverse aspects of regulated proteolysis and to study the molecular mechanisms behind bioactive small molecule action. Our interests are however not limited to basic research; rather, we aim to capitalize on our scientific findings for drug discovery or other medicinal applications.
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Selected Publications

    Journal articles

  • Merdanovic, Melisa; Burston, Steven G.; Schmitz, Anna Laura; Köcher, Steffen; Knapp, Stefan; Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Activation by substoichiometric inhibition
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 117 (2020) Nr. 3, pp. 1414 - 1418
    ISSN: 1091-6490; 0027-8424
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Sijbesma, Eline; Visser, Emira; Plitzko, Kathrin; Thiel, Philipp; Milroy, Lech-Gustav; Kaiser, Markus; Brunsveld, Luc; Ottmann, Christian
    Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 3954
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Pöhler, Robert; Krahn, Jan; van den Boom, Johannes; Dobrynin, Grzegorz; Kaschani, Farnusch; Eggenweiler, Hans-Michael; Zenke, Frank T.; Kaiser, Markus; Meyer, Hemmo
    A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases
    In: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 6, pp. 1576 - 1580
    ISSN: 1521-3773; 1433-7851; 0570-0833
    Online Full Text: dx.doi.org/
  • Ziemann, Sebastian; Van Der Linde, Karina; Lahrmann, Urs; Acar, Beyda; Kaschani, Farnusch; Colby, Tom; Kaiser, Markus; Ding, Yezhang; Schmelz, Eric; Huffaker, Alisa; Holton, Nicholas; Zipfel, Cyril; Doehlemann, Gunther
    An apoplastic peptide activates salicylic acid signalling in maize
    In: Nature Plants Vol. 4 (2018) Nr. 3, pp. 172 - 180
    ISSN: 2055-0278; 2055-026X
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Weith, Matthias; Seiler, Jonas; van den Boom, Johannes; Kracht, Matthias; Hülsmann, Julia; Primorac, Ivana; Del Pino Garcia, Javier; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Bollen, Mathieu; Meyer, Hemmo
    Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation
    In: Molecular Cell Vol. 72 (2018) Nr. 4, pp. 766 - 777
    ISSN: 1097-2765; 1097-4164
    Online Full Text: dx.doi.org/ (Open Access)
  • Zweerink, Susanne; Kallnik, Verena; Ninck, Sabrina; Nickel, Sabrina; Verheyen, Julia; Blum, Marcel; Wagner, Alexander; Feldmann, Ingo; Sickmann, Albert; Albers, Sonja-Verena; Bräsen, Christopher; Kaschani, Farnusch; Siebers, Bettina; Kaiser, Markus
    Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic Archaea
    In: Nature Communications Vol. 8 (2017) pp. 15352
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Köcher, Steffen; Rey, Juliana; Bongard, Jens; Tiaden, André N.; Meltzer, Michael; Richards, Peter J.; Ehrmann, Michael; Kaiser, Markus
    Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease Inhibitors
    In: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 29, Special Issue: 100th Anniversary of the Royal Australian Chemical Institute, pp. 8555 - 8558
    ISSN: 1521-3773; 1433-7851
    Online Full Text: dx.doi.org/
  • van den Boom, Johannes; Wolf, Markus; Weimann, Lena; Schulze, Nina; Li, Fanghua; Kaschani, Farnusch; Riemer, Anne; Zierhut, Christian; Kaiser, Markus; Iliakis, George; Funabiki, Hironori; Meyer, Hemmo
    VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair
    In: Molecular Cell Vol. 64 (2016) Nr. 1, pp. 189 - 198
    ISSN: 1097-4164; 1097-2765
    Online Full Text: dx.doi.org/ (Open Access)
  • Poepsel, Simon; Sprengel, Andreas; Sacca, Barbara; Kaschani, Farnusch; Kaiser, Markus; Gatsogiannis, Christos; Raunser, Stefan; Clausen, Tim; Ehrmann, Michael
    Determinants of amyloid fibril degradation by the PDZ protease HTRA1
    In: Nature Chemical Biology Vol. 11 (2015) Nr. 11, pp. 862 - 869
    ISSN: 1552-4450; 1552-4469
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Meesters, Christian; Mönig, Timon; Oeljeklaus, Julian; Krahn, Daniel; Westfall, Corey S.; Hause, Bettina; Jez, Joseph M; Kaiser, Markus; Kombrink, Erich
    A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana
    In: Nature Chemical Biology Vol. 10 (2014) Nr. 10, pp. 830 - 836
    ISSN: 1552-4469
    Online Full Text: dx.doi.org/
  • Oeljeklaus, Julian; Kaschani, Farnusch; Kaiser, Markus
    Streamlining chemical probe discovery : libraries of "fully functionalized" small molecules for phenotypic screening
    In: Angewandte Chemie International Edition Vol. 52 (2013) Nr. 5, pp. 1368 - 1370
    ISSN: 1521-3773
    Online Full Text: dx.doi.org/
  • Kaschani, Farnusch; Clerc, Jérôme; Krahn, Daniel; Bier, David; Hong, Tram Ngoc; Ottmann, Christian; Niessen, Sherry; Colby, Tom; Van Der Hoorn, Renier A. L.; Kaiser, Markus; van der Hoorn, Renier A. L.
    Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenases
    In: Angewandte Chemie International Edition Vol. 51 (2012) Nr. 21, pp. 5230 - 5233
    ISSN: 1521-3773; 1433-7851
    Online Full Text: dx.doi.org/
  • Stein, Martin L.; Beck, Philipp; Kaiser, Markus; Dudler, Robert; Becker, Christian F. W.; Groll, Michael
    One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 109 (2012) Nr. 45, pp. 18367 - 18371
    ISSN: 1091-6490; 0027-8424
    Online Full Text: dx.doi.org/
  • Thiel, Philipp; Kaiser, Markus; Ottmann, Christian
    Small-molecule stabilization of protein-protein interactions : An underestimated concept in drug discovery?
    In: Angewandte Chemie International Edition Vol. 51 (2012) Nr. 9, pp. 2012 - 2018
    ISSN: 1521-3773; 1433-7851
    Online Full Text: dx.doi.org/
  • Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    HTRA proteases : regulated proteolysis in protein quality control
    In: Nature Reviews Molecular Cell Biology Vol. 12 (2011) Nr. 3, pp. 152 - 162
    ISSN: 1471-0072
    Online Full Text: dx.doi.org/
  • Wetzel, Stefan; Wilk, Wolfram; Chammaa, Samy; Sperl, Bianca; Roth, Anke G.; Yektaoglu, Aybike; Renner, Steffen; Berg, Thorsten; Arenz, Christoph; Giannis, Athanassios; Oprea, Tudor I.; Rauh, Daniel; Kaiser, Markus; Waldmann, Herbert
    A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones
    In: Angewandte Chemie International Edition Vol. 49 (2010) Nr. 21, pp. 3666 - 3670
    ISSN: 0570-0833; 1433-7851
    Online Full Text: dx.doi.org/
  • Ottmann, Christian; Rose, Rolf; Huttenlocher, Franziska; Cedzich, Anna; Hauske, Patrick; Kaiser, Markus; Huber, Robert; Schaller, Andreas
    Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 106 (2009) Nr. 40, pp. 17223 - 17228
    ISSN: 1091-6490; 0027-8424
    Online Full Text: dx.doi.org/
  • Clerc, Jérôme; Groll, Michael; Illich, Damir J.; Bachmann, André S.; Huber, Robert; Schellenberg, Barbara; Dudler, Robert; Kaiser, Markus
    Synthetic and structural studies on Syringolin A and B reveal critical determinants for selectivity and potency of proteasome inhibition
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 106 (2009) Nr. 16, pp. 6507 - 6512
    ISSN: 1091-6490; 0027-8424
    Online Full Text
  • Knoth, Tanja; Warburg, Karin; Katzka, Catherine; Rai, Amrita; Wolf, Alexander; Brockmeyer, Andreas; Janning, Petra; Reubold, Thomas F.; Eschenburg, Susanne; Manstein, Dietmar J.; Hübel, Katja; Kaiser, Markus; Waldmann, Herbert; Manstein, Dietmar J.
    The ras pathway modulator melophlin a targets dynamins
    In: Angewandte Chemie International Edition Vol. 48 (2009) Nr. 39, pp. 7240 - 7245
    ISSN: 1433-7851; 1521-3773; 0570-0833
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/
  • Groll, Michael; Schellenberg, Barbara; Bachmann, André S.; Archer, Crystal R.; Huber, Robert; Powell, Tracy K.; Lindow, Steven; Kaiser, Markus; Dudler, Robert
    A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
    In: Nature Vol. 452 (2008) pp. 755 - 758
    ISSN: 0028-0836; 1476-4687
    Online Full Text
  • Meltzer, Michael; Hasenbein, Sonja; Hauske, Patrick; Kucz, Nicolette; Merdanovic, Melisa; Grau, Sandra; Beil, Alexandra; Jones, Dafydd; Krojer, Tobias; Clausen, Tim; Ehrmann, Michael; Kaiser, Markus
    Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control
    In: Angewandte Chemie International Edition Vol. 47 (2008) Nr. 7, pp. 1332 - 1334
    ISSN: 0044-8249; 0932-2140
    Online Full Text: dx.doi.org/
  • Nören-Müller, Andrea; Wilk, Wolfram; Krishna, Saxena; Schwalbe, Harald; Kaiser, Markus; Waldmann, Herbert
    Discovery of a New Class of Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B by Biology-Oriented Synthesis
    In: Angewandte Chemie - International Edition Vol. 47 (2008) Nr. 32, pp. 5973 - 5977
    ISSN: 0044-8249; 0570-0833; 1433-7851
    Online Full Text
  • Wang, Zheming; Gu, Christian; Colby, Tom; Shindo, Takayuki; Balamurugan, Rengarajan; Waldmann, Herbert; Kaiser, Markus; van der Hoorn, Renier A.L.
    β-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.
    In: Nature chemical biology Vol. 4 (2008) Nr. 9, pp. 557 - 563
    ISSN: 1552-4450
    Online Full Text
  • Kaiser, Markus; Groll, Michael; Renner, Christian; Huber, Robert; Moroder, Luis
    The Core Structure of TMC-95A Is a Promising Lead for Reversible Proteasome Inhibition
    In: Angewandte Chemie - International Edition Vol. 41 (2002) Nr. 5, pp. 780 - 783
    ISSN: 0044-8249; 0570-0833; 1433-7851
    Online Full Text
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