ZMB Member Markus Kaiser

ZMB Member
Markus Kaiser

Next ZMB-Member
portrait photo of ZMB member Markus Kaiser
© UDE//Bettina Engel-Albustin

Prof. Dr. Markus Kaiser

Group

Chemical Biology

Center of Medical Biotechnology (ZMB)
Faculty of Biology
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

Research Overview

The Kaiser group develops and uses chemical biology approaches to investigate diverse aspects of regulated proteolysis and to study the molecular mechanisms behind bioactive small molecule action. Our interests are however not limited to basic research; rather, we aim to capitalize on our scientific findings for drug discovery or other medicinal applications.
Read more

Press Releases

Selected Publications

    Journal articles

  • Katz, Liora S.; Visser, Emira J.; Plitzko, Kathrin F.; Pennings, Marloes A. M.; Cossar, Peter J.; Tse, Isabelle L.; Kaiser, Markus; Brunsveld, Luc; Ottmann, Christian; Scott, Donald K.
    Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity
    In: Nature Communications , Vol. 16 2025, Nr. 1, 2110
    DOI (Open Access)
  • Sewald, Leonard; Tabak, Werner W. A.; Fehr, Lorenz; Zolg, Samuel; Najdzion, Maja; Verhoef, Carlo J. A.; Podlesainski, David; Geiss-Friedlander, Ruth; Lammens, Alfred; Kaschani, Farnusch; Hellerschmied, Doris; Huber, Robert; Kaiser, Markus
    Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors
    In: Nature Communications , Vol. 16 2025, Nr. 1, 3208
    DOI (Open Access)
  • Chen, Changlong; Buscaill, Pierre; Sanguankiattichai, Nattapong; Huang, Jie; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A. L.
    Extracellular plant subtilases dampen cold-shock peptide elicitor levels
    In: Nature Plants , Vol. 10 2024, Nr. 11, pp. 1749 – 1760
    DOI (Open Access)
  • Beaufort, Nathalie; Ingendahl, Linda; Merdanovic, Melisa; Schmidt, Andree; Podlesainski, David; Richter, Tim; Neumann, Thorben; Kuszner, Michael; Vetter, Ingrid R.; Stege, Patricia; Burston, Steven G.; Filipovic, Anto; Ruiz-Blanco, Yasser B.; Bravo Rodriguez, Kenny; Mieres-Perez, Joel; Beuck, Christine; Uebel, Stephan; Zobawa, Monika; Schillinger, Jasmin; Malik, Rainer; Todorov-Völgyi, Katalin; Rey, Juliana; Roberti, Annabell; Hagemeier, Birte; Wefers, Benedikt; Müller, Stephan A.; Wurst, Wolfgang; Sanchez-Garcia, Elsa; Zimmermann, Alexander; Hu, Xiao-Yu; Clausen, Tim; Huber, Robert; Lichtenthaler, Stefan F.; Schmuck, Carsten; Giese, Michael; Kaiser, Markus; Ehrmann, Michael; Dichgans, Martin
    Rational correction of pathogenic conformational defects in HTRA1
    In: Nature Communications , Vol. 15 2024, Nr. 1, 5944
    DOI (Open Access)
  • Buscaill, Pierre; Sanguankiattichai, Nattapong; Kaschani, Farnusch; Huang, Jie; Mooney, Brian C.; Li, Yuge; Lyu, Joy; Sueldo, Daniela; Kaiser, Markus; van der Hoorn, Renier A. L.
    Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast
    In: Nature Communications , Vol. 15 2024, Nr. 1, 10431
    DOI (Open Access)
  • Day, Matthew; Tetik, Bilal; Parlak, Milena; Almeida-Hernández, Yasser; Räschle, Markus; Kaschani, Farnusch; Siegert, Heike; Marko, Anika; Sanchez-Garcia, Elsa; Kaiser, Markus; Barker, Isabel A.; Pearl, Laurence H.; Oliver, Antony W.; Boos, Dominik
    TopBP1 utilises a bipartite GINS binding mode to support genome replication
    In: Nature Communications , Vol. 15 2024, Nr. 1, 1797
    DOI, Online Full Text (Open Access)
  • Hoi, David M.; Junker, Sabryna; Junk, Lukas; Schwechel, Kristin; Fischel, Katharina; Podlesainski, David; Hawkins, Paige M.E.; van Geelen, Lasse; Kaschani, Farnusch; Leodolter, Julia; Morreale, Francesca Ester; Kleine, Stefan; Guha, Somraj; Rumpel, Klaus; Schmiedel, Volker M.; Weinstabl, Harald; Meinhart, Anton; Payne, Richard J.; Kaiser, Markus; Hartl, Markus; Boehmelt, Guido; Kazmaier, Uli; Kalscheuer, Rainer; Clausen, Tim
    Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival
    In: Cell , Vol. 186 2023, Nr. 10, pp. 2176 – 2192.e22
    DOI (Open Access)
  • Blüggel, Mike; Kröning, Alexander; Kracht, Matthias; van den Boom, Johannes; Dabisch, Matthias; Göhring, Anna; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter; Meyer, Hemmo; Beuck, Christine
    The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase
    In: Nature Communications , Vol. 14 2023, Nr. 1, 3258
    DOI, Online Full Text (Open Access)
  • Morreale, Francesca E.; Kleine, Stefan; Leodolter, Julia; Junker, Sabryna; Hoi, David M.; Ovchinnikov, Stepan; Okun, Anastasia; Kley, Juliane; Kurzbauer, Robert; Junk, Lukas; Guha, Somraj; Podlesainski, David; Kazmaier, Uli; Boehmelt, Guido; Weinstabl, Harald; Rumpel, Klaus; Schmiedel, Volker M.; Hartl, Markus; Haselbach, David; Meinhart, Anton; Kaiser, Markus; Clausen, Tim
    BacPROTACs mediate targeted protein degradation in bacteria
    In: Cell , Vol. 185 2022, Nr. 13, pp. 2338 – 2353.e18
    DOI (Open Access)
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander
    Persister state-directed transitioning and vulnerability in melanoma
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Nature Communications , Vol. 13 2022, Nr. 1, pp. 35 – 36
    DOI, Online Full Text (Open Access)
  • Sijbesma, Eline; Visser, Emira; Plitzko, Kathrin; Thiel, Philipp; Milroy, Lech-Gustav; Kaiser, Markus; Brunsveld, Luc; Ottmann, Christian
    Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions
    In: Nature Communications , Vol. 11 2020, Nr. 1, pp. 3954
    DOI (Open Access)
  • Ziemann, Sebastian; Van Der Linde, Karina; Lahrmann, Urs; Acar, Beyda; Kaschani, Farnusch; Colby, Tom; Kaiser, Markus; Ding, Yezhang; Schmelz, Eric; Huffaker, Alisa; Holton, Nicholas; Zipfel, Cyril; Doehlemann, Gunther
    An apoplastic peptide activates salicylic acid signalling in maize
    In: Nature Plants , Vol. 4 2018, Nr. 3, pp. 172 – 180
    DOI (Open Access)
  • Weith, Matthias; Seiler, Jonas; van den Boom, Johannes; Kracht, Matthias; Hülsmann, Julia; Primorac, Ivana; Del Pino Garcia, Javier; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Bollen, Mathieu; Meyer, Hemmo
    Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation
    In: Molecular Cell , Vol. 72 2018, Nr. 4, pp. 766 – 777
    DOI (Open Access)
  • Zweerink, Susanne; Kallnik, Verena; Ninck, Sabrina; Nickel, Sabrina; Verheyen, Julia; Blum, Marcel; Wagner, Alexander; Feldmann, Ingo; Sickmann, Albert; Albers, Sonja-Verena; Bräsen, Christopher; Kaschani, Farnusch; Siebers, Bettina; Kaiser, Markus
    Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic Archaea
    In: Nature Communications , Vol. 8 2017, pp. 15352
    DOI (Open Access)
  • van den Boom, Johannes; Wolf, Markus; Weimann, Lena; Schulze, Nina; Li, Fanghua; Kaschani, Farnusch; Riemer, Anne; Zierhut, Christian; Kaiser, Markus; Iliakis, George; Funabiki, Hironori; Meyer, Hemmo
    VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair
    In: Molecular Cell , Vol. 64 2016, Nr. 1, pp. 189 – 198
    DOI (Open Access)
  • Poepsel, Simon; Sprengel, Andreas; Sacca, Barbara; Kaschani, Farnusch; Kaiser, Markus; Gatsogiannis, Christos; Raunser, Stefan; Clausen, Tim; Ehrmann, Michael
    Determinants of amyloid fibril degradation by the PDZ protease HTRA1
    In: Nature Chemical Biology , Vol. 11 2015, Nr. 11, pp. 862 – 869
    DOI (Open Access)
  • Meesters, Christian; Mönig, Timon; Oeljeklaus, Julian; Krahn, Daniel; Westfall, Corey S.; Hause, Bettina; Jez, Joseph M; Kaiser, Markus; Kombrink, Erich
    A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana
    In: Nature Chemical Biology , Vol. 10 2014, Nr. 10, pp. 830 – 836
    DOI
  • Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    HTRA proteases : regulated proteolysis in protein quality control
    In: Nature Reviews Molecular Cell Biology , Vol. 12 2011, Nr. 3, pp. 152 – 162
    DOI
  • Groll, Michael; Schellenberg, Barbara; Bachmann, André S.; Archer, Crystal R.; Huber, Robert; Powell, Tracy K.; Lindow, Steven; Kaiser, Markus; Dudler, Robert
    A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
    In: Nature , Vol. 452 2008, pp. 755 – 758
  • Wang, Zheming; Gu, Christian; Colby, Tom; Shindo, Takayuki; Balamurugan, Rengarajan; Waldmann, Herbert; Kaiser, Markus; van der Hoorn, Renier A.L.
    β-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.
    In: Nature Chemical Biology , Vol. 4 2008, Nr. 9, pp. 557 – 563
Read more