ZMB Member Markus Kaiser
ZMB Member
Markus Kaiser
Next ZMB-Member
Prof. Dr. Markus Kaiser
Group
Chemical BiologyCenter of Medical Biotechhnology
Faculty of Biology
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen
- +49 201 183 4980
- Website
- Selected Publications
- Publication Metrics
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- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
The Kaiser group develops and uses chemical biology approaches to investigate diverse aspects of regulated proteolysis and to study the molecular mechanisms behind bioactive small molecule action. Our interests are however not limited to basic research; rather, we aim to capitalize on our scientific findings for drug discovery or other medicinal applications.
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Selected Publications
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Activation by substoichiometric inhibitionIn: Proceedings of the National Academy of Sciences of the United States of America Vol. 117 (2020) Nr. 3, pp. 1414 - 1418
ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactionsIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 3954
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPasesIn: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 6, pp. 1576 - 1580
ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/ -
An apoplastic peptide activates salicylic acid signalling in maizeIn: Nature Plants Vol. 4 (2018) Nr. 3, pp. 172 - 180
ISSN: 2055-0278; 2055-026XOnline Full Text: dx.doi.org/ Online Full Text (Open Access) -
Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme FormationIn: Molecular Cell Vol. 72 (2018) Nr. 4, pp. 766 - 777
ISSN: 1097-2765; 1097-4164Online Full Text: dx.doi.org/ (Open Access) -
Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic ArchaeaIn: Nature Communications Vol. 8 (2017) pp. 15352
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease InhibitorsIn: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 29, Special Issue: 100th Anniversary of the Royal Australian Chemical Institute, pp. 8555 - 8558
ISSN: 1521-3773; 1433-7851Online Full Text: dx.doi.org/ -
VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break RepairIn: Molecular Cell Vol. 64 (2016) Nr. 1, pp. 189 - 198
ISSN: 1097-4164; 1097-2765Online Full Text: dx.doi.org/ (Open Access) -
Determinants of amyloid fibril degradation by the PDZ protease HTRA1In: Nature Chemical Biology Vol. 11 (2015) Nr. 11, pp. 862 - 869
ISSN: 1552-4450; 1552-4469Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thalianaIn: Nature Chemical Biology Vol. 10 (2014) Nr. 10, pp. 830 - 836
ISSN: 1552-4469Online Full Text: dx.doi.org/ -
Streamlining chemical probe discovery : libraries of "fully functionalized" small molecules for phenotypic screeningIn: Angewandte Chemie International Edition Vol. 52 (2013) Nr. 5, pp. 1368 - 1370
ISSN: 1521-3773Online Full Text: dx.doi.org/ -
Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenasesIn: Angewandte Chemie International Edition Vol. 51 (2012) Nr. 21, pp. 5230 - 5233
ISSN: 1521-3773; 1433-7851Online Full Text: dx.doi.org/ -
One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitorIn: Proceedings of the National Academy of Sciences of the United States of America Vol. 109 (2012) Nr. 45, pp. 18367 - 18371
ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/ -
Small-molecule stabilization of protein-protein interactions : An underestimated concept in drug discovery?In: Angewandte Chemie International Edition Vol. 51 (2012) Nr. 9, pp. 2012 - 2018
ISSN: 1521-3773; 1433-7851Online Full Text: dx.doi.org/ -
HTRA proteases : regulated proteolysis in protein quality controlIn: Nature Reviews Molecular Cell Biology Vol. 12 (2011) Nr. 3, pp. 152 - 162
ISSN: 1471-0072Online Full Text: dx.doi.org/ -
A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-PyronesIn: Angewandte Chemie International Edition Vol. 49 (2010) Nr. 21, pp. 3666 - 3670
ISSN: 0570-0833; 1433-7851Online Full Text: dx.doi.org/ -
Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3In: Proceedings of the National Academy of Sciences of the United States of America Vol. 106 (2009) Nr. 40, pp. 17223 - 17228
ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/ -
Synthetic and structural studies on Syringolin A and B reveal critical determinants for selectivity and potency of proteasome inhibitionIn: Proceedings of the National Academy of Sciences of the United States of America Vol. 106 (2009) Nr. 16, pp. 6507 - 6512
ISSN: 1091-6490; 0027-8424 -
A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanismIn: Nature Vol. 452 (2008) pp. 755 - 758
ISSN: 0028-0836; 1476-4687 -
Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality controlIn: Angewandte Chemie International Edition Vol. 47 (2008) Nr. 7, pp. 1332 - 1334
ISSN: 0044-8249; 0932-2140Online Full Text: dx.doi.org/ -
Discovery of a New Class of Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B by Biology-Oriented SynthesisIn: Angewandte Chemie - International Edition Vol. 47 (2008) Nr. 32, pp. 5973 - 5977
ISSN: 0044-8249; 0570-0833; 1433-7851 -
β-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.In: Nature chemical biology Vol. 4 (2008) Nr. 9, pp. 557 - 563
ISSN: 1552-4450 -
The Core Structure of TMC-95A Is a Promising Lead for Reversible Proteasome InhibitionIn: Angewandte Chemie - International Edition Vol. 41 (2002) Nr. 5, pp. 780 - 783
ISSN: 0044-8249; 0570-0833; 1433-7851