ZMB Member Farnusch Kaschani

ZMB Member
Farnusch Kaschani

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portrait photo of ZMB member Farnusch Kaschani
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Dr. Farnusch Kaschani

Group Chemical Proteomics

Analytics Core Facility Essen (ACE)

Center of Medical Biotechnology (ZMB)
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

Research Overview

The Analytics Core Facility Essen (ACE) is a central facility of the Center of Medical Biotechnology (ZMB) and of the Faculty of Biology of the University Duisburg-Essen. It offers access to state-of-the-art mass spectrometry-based proteomics for internal and external users. The timely technical equipment of the ACE allows us to provide a wide variety of different “bottom-up” and “top-down” proteomics methods. Furthermore, we also develop innovative solutions for project-specific demands. The service comprises all aspects of mass spectrometry-based proteomics, starting from technical advice and project planning, sample preparation and analysis to data analysis, data management and interpretation of results. We are also listed in the RIsources Poral of the DFG (RI_00466).
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Selected Publications

    Journal articles

  • Schmerling, Christian; Schroeder, Carsten; Zhou, Xiaoxiao; Bost, Jan; Waßmer, Bianca; Ninck, Sabrina; Busche, Tobias; Montero, Lidia; Kaschani, Farnusch; Schmitz, Oliver J.; Kalinowski, Jörn; Kaiser, Markus; Albers, Sonja-Verena; Bräsen, Christopher; Siebers, Bettina
    An unusual glycerol-3-phosphate dehydrogenase in Sulfolobus acidocaldarius elucidates the diversity of glycerol metabolism across Archaea
    In: Communications Biology Vol. 8 (2025) Nr. 1, 539
    Online Full Text: dx.doi.org/ (Open Access)
  • Salguero-Linares, Jose; Armengot, Laia; Ayet, Joel; Ruiz-Solaní, Nerea; Saile, Svenja C; Salas-Gómez, Marta; Fernandez, Esperanza; Denolf, Lode; Navarrete, Fernando; Krumbach, Jenna; Kaiser, Markus; Stael, Simon; Van Breusegem, Frank; Gevaert, Kris; Kaschani, Farnusch; Petersen, Morten; El Kasmi, Farid; Valls, Marc; Coll, Núria S
    Lack of AtMC1 catalytic activity triggers autoimmunity dependent on NLR stability
    In: EMBO Reports (2025) in press
    Online Full Text: dx.doi.org/ (Open Access)
  • Sewald, Leonard; Tabak, Werner W. A.; Fehr, Lorenz; Zolg, Samuel; Najdzion, Maja; Verhoef, Carlo J. A.; Podlesainski, David; Geiss-Friedlander, Ruth; Lammens, Alfred; Kaschani, Farnusch; Hellerschmied, Doris; Huber, Robert; Kaiser, Markus
    Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors
    In: Nature Communications Vol. 16 (2025) Nr. 1, 3208
    Online Full Text: dx.doi.org/ (Open Access)
  • Sternberg, Anna; Borger, Jennifer Lynne; Thies, Mathilda; Matena, Anja; Blüggel, Mike; Kamba, Bianca; Beuck, Christine; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter
    The Actin‐Binding Prolyl‐Isomerase Par17 Sustains Its Substrate Selectivity by Interdomain Allostery
    In: Proteins: Structure, Function and Genetics (2025) in press
    Online Full Text: dx.doi.org/ (Open Access)
  • Sueldo, Daniela J.; Godson, Alice; Kaschani, Farnusch; Krahn, Daniel; Kessenbrock, Till; Buscaill, Pierre; Schofield, Christopher J.; Kaiser, Markus; van der Hoorn, Renier A. L.
    Activity-based proteomics uncovers suppressed hydrolases and a neo-functionalised antibacterial enzyme at the plant–pathogen interface
    In: New Phytologist Vol. 241 (2024) Nr. 1, pp. 394 - 408
    Online Full Text: dx.doi.org/ (Open Access)
  • Kaplieva-Dudek, I.; Samak, Nadia; Bormann, Jenny; Kaschani, Farnusch; Kaiser, Markus; Meckenstock, Rainer
    Characterization of 2-phenanthroate:CoA ligase from the sulfate-reducing, phenanthrene-degrading enrichment culture TRIP
    In: Applied and Environmental Microbiology Vol. 90 (2024) Nr. 10, e0129624
    Online Full Text: dx.doi.org/ (Open Access)
  • Sowislok, Andrea; Busch, André; Kaschani, Farnusch; Kaiser, Markus; Jäger, Marcus
    Differences in the Synovial Fluid Proteome of Septic and Aseptic Implant Failure
    In: Antibiotics Vol. 13 (2024) Nr. 4, 346
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Font-Farre, Maria; Brown, Daniel; Toth, Reka; Mahadevan, Chidambareswaren; Brazier-Hicks, Melissa; Morimoto, Kyoko; Kaschani, Farnusch; Sinclair, John; Dale, Richard; Hall, Samantha; Morris, Melloney; Kaiser, Markus; Wright, Aaron T.; Burton, Jonathan; van der Hoorn, Renier A. L.
    Discovery of active mouse, plant and fungal cytochrome P450s in endogenous proteomes and upon expression in planta
    In: Scientific Reports Vol. 14 (2024) Nr. 1, 10091
    Online Full Text: dx.doi.org/ (Open Access)
  • Ninck, Sabrina; Klaus, Thomas; Kochetkova, Tatiana V.; Esser, Sarah P.; Sewald, Leonard; Kaschani, Farnusch; Bräsen, Christopher; Probst, Alexander J.; Kublanov, Ilya V.; Siebers, Bettina; Kaiser, Markus
    Environmental activity-based protein profiling for function-driven enzyme discovery from natural communities
    In: Environmental Microbiomes Vol. 19 (2024) Nr. 1, 36
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Chen, Changlong; Buscaill, Pierre; Sanguankiattichai, Nattapong; Huang, Jie; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A. L.
    Extracellular plant subtilases dampen cold-shock peptide elicitor levels
    In: Nature Plants Vol. 10 (2024) Nr. 11, pp. 1749 - 1760
    Online Full Text: dx.doi.org/ (Open Access)
  • Parsons, Jack D.; Cocker, Clare R.; East, Alison K.; Wheatley, Rachel M.; Ramachandran, Vinoy K.; Kaschani, Farnusch; Kaiser, Markus; Poole, Philip S.
    Factors governing attachment of Rhizobium leguminosarum to legume roots at acid, neutral, and alkaline pHs
    In: mSystems Vol. 9 (2024) Nr. 9, e0042224
    Online Full Text: dx.doi.org/ (Open Access)
  • Font Farre, Maria; Brown, Daniel; König, Maurice; Killinger, Brian J.; Kaschani, Farnusch; Kaiser, Markus; Wright, Aaron T.; Burton, Jonathan; van der Hoorn, Renier A.L.
    Glutathione Transferase Photoaffinity Labeling Displays GST Induction by Safeners and Pathogen Infection
    In: Plant and Cell Physiology Vol. 65 (2024) Nr. 1, pp. 128 - 141
    Online Full Text: dx.doi.org/ (Open Access)
  • Schillinger, Jasmin; Koci, Michelle; Bravo-Rodriguez, Kenny; Heilmann, Geronimo; Kaschani, Farnusch; Kaiser, Markus; Beuck, Christine; Luecke, Hartmut; Huber, Robert; Hellerschmied-Jelinek, Doris; Burston, Steven G.; Ehrmann, Michael
    High resolution analysis of proteolytic substrate processing
    In: The Journal of Biological Chemistry (JBC) Vol. 300 (2024) Nr. 11, 107812
    Online Full Text: dx.doi.org/ (Open Access)
  • Pol, Savina Abraham; Liljenberg, Sara; Barr, Jack; Simon, Gina; Wong-Dilworth, Luis; Paterson, Danielle L.; Berishvili, Vladimir P.; Bottanelli, Francesca; Kaschani, Farnusch; Kaiser, Markus; Pettersson, Mariell; Hellerschmied, Doris
    Induced degradation of SNAP-fusion proteins
    In: RSC Chemical Biology Vol. 5 (2024) Nr. 12, pp. 1232 - 1247
    Online Full Text: dx.doi.org/ (Open Access)
  • Pleuger, Richard; Cozma, Christian; Hohoff, Simone; Denkhaus, Christian; Dudziak, Alexander; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Vetter, Ingrid R.; Westermann, Stefan
    Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor
    In: Current Biology Vol. 34 (2024) Nr. 11, pp. 2279 - 2293.e6
    Online Full Text: dx.doi.org/ (Open Access)
  • Buscaill, Pierre; Sanguankiattichai, Nattapong; Kaschani, Farnusch; Huang, Jie; Mooney, Brian C.; Li, Yuge; Lyu, Joy; Sueldo, Daniela; Kaiser, Markus; van der Hoorn, Renier A. L.
    Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast
    In: Nature Communications Vol. 15 (2024) Nr. 1, 10431
    Online Full Text: dx.doi.org/ (Open Access)
  • Podlesainski, David; Adeniyi, Emmanuel T.; Gröner, Yvonne; Schulz, Florian; Krisilia, Violetta; Rehberg, Nidja; Richter, Tim; Sehr, Daria; Xie, Huzhuyue; Simons, Viktor E.; Kiffe-Delf, Anna-Lene; Kaschani, Farnusch; Ioerger, Thomas R.; Kaiser, Markus; Kalscheuer, Rainer
    The anti-tubercular callyaerins target the Mycobacterium tuberculosis-specific non-essential membrane protein Rv2113
    In: Cell Chemical Biology Vol. 31 (2024) Nr. 10, pp. 1755 - 1771.e73
    Online Full Text: dx.doi.org/ (Open Access)
  • Zheng, Kaijie; Lyu, Joy C.; Thomas, Emma L.; Schuster, Mariana; Sanguankiattichai, Nattapong; Ninck, Sabrina; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A. L.
    The proteome of Nicotiana benthamiana is shaped by extensive protein processing
    In: New Phytologist Vol. 243 (2024) Nr. 3, pp. 1034 - 1049
    Online Full Text: dx.doi.org/ (Open Access)
  • Day, Matthew; Tetik, Bilal; Parlak, Milena; Almeida-Hernández, Yasser; Räschle, Markus; Kaschani, Farnusch; Siegert, Heike; Marko, Anika; Sanchez-Garcia, Elsa; Kaiser, Markus; Barker, Isabel A.; Pearl, Laurence H.; Oliver, Antony W.; Boos, Dominik
    TopBP1 utilises a bipartite GINS binding mode to support genome replication
    In: Nature Communications Vol. 15 (2024) Nr. 1, 1797
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Ninck, Sabrina; Halder, Vivek; Krahn, Jan; Beisser, Daniela; Resch, Sarah; Dodds, Isobel; Scholtysik, René; Bormann, Jenny; Sewald, Leonard; Gupta, Mainak D.; Heilmann, Geronimo; Bhandari, Deepak D.; Morimoto, Kyoko; Buscaill, Pierre; Hause, Bettina; van der Hoorn, Renier A. L.; Kaschani, Farnusch; Kaiser, Markus
    Chemoproteomics Reveals the Pan-HER Kinase Inhibitor Neratinib To Target an Arabidopsis Epoxide Hydrolase Related to Phytohormone Signaling
    In: ACS Chemical Biology Vol. 18 (2023) Nr. 5, pp. 1076 - 1088
    Online Full Text: dx.doi.org/
  • Hoi, David M.; Junker, Sabryna; Junk, Lukas; Schwechel, Kristin; Fischel, Katharina; Podlesainski, David; Hawkins, Paige M.E.; van Geelen, Lasse; Kaschani, Farnusch; Leodolter, Julia; Morreale, Francesca Ester; Kleine, Stefan; Guha, Somraj; Rumpel, Klaus; Schmiedel, Volker M.; Weinstabl, Harald; Meinhart, Anton; Payne, Richard J.; Kaiser, Markus; Hartl, Markus; Boehmelt, Guido; Kazmaier, Uli; Kalscheuer, Rainer; Clausen, Tim
    Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival
    In: Cell Vol. 186 (2023) Nr. 10, pp. 2176 - 2192.e22
    Online Full Text: dx.doi.org/ (Open Access)
  • Andlovic, Blaž; Heilmann, Geronimo; Ninck, Sabrina; Andrei, Sebastian A.; Centorrino, Federica; Higuchi, Yusuke; Kato, Nobuo; Brunsveld, Luc; Arkin, Michelle; Menninger, Sascha; Choidas, Axel; Wolf, Alexander; Klebl, Bert; Kaschani, Farnusch; Kaiser, Markus; Eickhoff, Jan; Ottmann, Christian
    IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization
    In: Cell Chemical Biology Vol. 30 (2023) Nr. 6, pp. 573 - 590.e6
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Rüttermann, Maximilian; Koci, Michelle; Lill, Pascal; Geladas, Ermis Dionysios; Kaschani, Farnusch; Klink, Björn Udo; Erdmann, Ralf; Gatsogiannis, Christos
    Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate
    In: Nature Communications Vol. 14 (2023) Nr. 1, 5942
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Oelschläger, Lisa; Stahl, Paul; Kaschani, Farnusch; Stauber, Roland H.; Knauer, Shirley K.; Hensel, Astrid
    Taspase1 facilitates Topoisomerase IIβ-mediated DNA double-strand breaks driving estrogen-induced transcription
    In: Cells Vol. 2023 (2023) Nr. 12, 363
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Blüggel, Mike; Kröning, Alexander; Kracht, Matthias; van den Boom, Johannes; Dabisch, Matthias; Göhring, Anna; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter; Meyer, Hemmo; Beuck, Christine
    The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase
    In: Nature Communications Vol. 14 (2023) Nr. 1, 3258
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Kiselev, Andrei; Camborde, Laurent; Carballo, Laura Ossorio; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A. L.; Gaulin, Elodie
    The root pathogen Aphanomyces euteiches secretes modular proteases in pea apoplast during host infection
    In: Frontiers in Plant Science (FPLS) Vol. 14 (2023) 1140101
    Online Full Text: dx.doi.org/ (Open Access)
  • Klaus, Thomas; Ninck, Sabrina; Albersmeier, Andreas; Busche, Tobias; Wibberg, Daniel; Jiang, Jianbing; Elcheninov, Alexander G.; Zayulina, Kseniya S.; Kaschani, Farnusch; Bräsen, Christopher; Overkleeft, Herman S.; Kalinowski, Jörn; Kublanov, Ilya V.; Kaiser, Markus; Siebers, Bettina
    Activity-Based Protein Profiling for the Identification of Novel Carbohydrate-Active Enzymes Involved in Xylan Degradation in the Hyperthermophilic Euryarchaeon Thermococcus sp. Strain 2319x1E
    In: Frontiers in Microbiology Vol. 12 (2022) 734039
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Schmerling, Christian; Sewald, Leonard; Heilmann, Geronimo; Witfeld, Frederick; Begerow, Dominik; Jensen, Kenneth; Bräsen, Christopher; Kaschani, Farnusch; Overkleeft, Herman S.; Siebers, Bettina; Kaiser, Markus
    Erratum: Author Correction: Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling (Communications biology (2022) 5 1 (1254))
    In: Communications Biology Vol. 5 (2022) Nr. 1, pp. 1319
    Online Full Text: dx.doi.org/ (Open Access)
  • Schmerling, Christian; Sewald, Leonard; Heilmann, Geronimo; Witfeld, Frederick; Begerow, Dominik; Jensen, Kenneth; Bräsen, Christopher; Kaschani, Farnusch; Overkleeft, Herman S.; Siebers, Bettina; Kaiser, Markus
    Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling
    In: Communications Biology Vol. 5 (2022) Nr. 1, 1254
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander;
    Persister state-directed transitioning and vulnerability in melanoma
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Nature Communications Vol. 13 (2022) Nr. 1, pp. 35 - 36
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Abreha, Kibrom B.; Alexandersson, Erik; Resjö, Svante; Lankinen, Åsa; Sueldo, Daniela; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A. L.; Levander, Fredrik; Andreasson, Erik
    Article leaf apoplast of field-grown potato analyzed by quantitative proteomics and activity-based protein profiling
    In: International Journal of Molecular Sciences (IJMS) Vol. 22 (2021) Nr. 21, 12033
    Online Full Text: dx.doi.org/ (Open Access)
  • van Geelen, Lasse; Kaschani, Farnusch; Sazzadeh, Shabnam S.; Adeniyi, Emmanuel T.; Meier, Dieter; Proksch, Peter; Pfeffer, Klaus; Kaiser, Markus; Ioerger, Thomas R.; Kalscheuer, Rainer
    Correction to : Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteria
    In: Applied Microbiology and Biotechnology Vol. 105 (2021) Nr. 14-15, pp. 6119 - 6119
    Online Full Text: dx.doi.org/ (Open Access)
  • Dorsch, Madeleine; Kowalczyk, Manuela; Planque, Mélanie; Heilmann, Geronimo; Urban, Sebastian; Dujardin, Philip; Forster, Jan; Ueffing, Kristina; Nothdurft, Silke; Oeck, Sebastian; Paul, Annika; Liffers, Sven T.; Kaschani, Farnusch; Kaiser, Markus; Schramm, Alexander; Siveke, Jens; Winslow, Monte M.; Fendt, Sarah-Maria; Nalbant, Perihan; Grüner, Barbara M.
    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
    In: Cell Reports Vol. 37 (2021) Nr. 8, 110056
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • van den Boom, Johannes; Kück, Anja; Kravic, Bojana; Müschenborn, Helen; Giesing, Maike; Pan, Dongqing; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Meyer, Hemmo
    Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly
    In: Nature Structural & Molecular Biology Vol. 28 (2021) Nr. 12, pp. 964 - 971
    Online Full Text: dx.doi.org/
  • van der Woude, Lennard; Piotrowski, Markus; Klaasse, Gruson; Paulus, Judith K.; Krahn, Daniel; Ninck, Sabrina; Kaschani, Farnusch; Kaiser, Markus; Novák, Ondřej; Ljung, Karin; Bulder, Suzanne; van Verk, Marcel; Snoek, Basten L.; Fiers, Martijn; Martin, Nathaniel I.; van der Hoorn, Renier A. L.; Robert, Stéphanie; Smeekens, Sjef; van Zanten, Martijn
    The chemical compound ‘Heatin’ stimulates hypocotyl elongation and interferes with the Arabidopsis NIT1-subfamily of nitrilases
    In: The Plant Journal Vol. 106 (2021) Nr. 6, pp. 1523 - 1540
    Online Full Text: dx.doi.org/ (Open Access)
  • Smolin, Daniel; Tötsch, Niklas; Grad, Jean-Noël; Linders, Jürgen; Kaschani, Farnusch; Kaiser, Markus; Kirsch, Michael; Hoffmann, Daniel; Schrader, Thomas
    Accelerated trypsin autolysis by affinity polymer templates
    In: RSC Advances Vol. 10 (2020) Nr. 48, pp. 28711 - 28719
    Online Full Text: dx.doi.org/ (Open Access)
  • Smolin, Daniel; Tötsch, Niklas; Grad, Jean-Noël; Linders, Jürgen; Kaschani, Farnusch; Kaiser, Markus; Kirsch, Michael; Hoffmann, Daniel; Schrader, Thomas
    Accelerated trypsin autolysis by affinity polymer templates
    In: RSC Advances Vol. 10 (2020) Nr. 48, pp. 28711 - 28719
    Online Full Text: dx.doi.org/ (Open Access)
  • Bach-Pages, Marcel; Homma, Felix; Kourelis, Jiorgos; Kaschani, Farnusch; Mohammed, Shabaz; Kaiser, Markus; van der Hoorn, Renier A. L.; Castello, Alfredo; Preston, Gail M.
    Discovering the RNA-binding proteome of plant leaves with an improved RNA interactome capture method
    In: Biomolecules Vol. 10 (2020) Nr. 4, 661
    Online Full Text: dx.doi.org/ (Open Access)
  • van Geelen, Lasse; Kaschani, Farnusch; Sazzadeh, Shabnam S.; Adeniyi, Emmanuel T.; Meier, Dieter; Proksch, Peter; Pfeffer, Klaus; Kaiser, Markus; Ioerger, Thomas R.; Kalscheuer, Rainer
    Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteria
    In: Applied Microbiology and Biotechnology Vol. 104 (2020) Nr. 13, pp. 5985 - 5998
    Online Full Text: dx.doi.org/ (Open Access)
  • Kracht, Matthias; van den Boom, Johannes; Seiler, Jonas; Kröning, Alexander; Kaschani, Farnusch; Kaiser, Markus; Meyer, Hemmo
    Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain Adapters
    In: Journal of Molecular Biology (JMB) Vol. 432 (2020) Nr. 23, pp. 6061 - 6074
    Online Full Text: dx.doi.org/
  • Göhring, Anna; Michin, Irina; Gerdes, Tina; Schulze, Nina; Blüggel, Mike; Rehic, Edisa; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter
    Targeting of parvulin interactors by diazirine mediated cross-linking discloses a cellular role of human Par14/17 in actin polymerization
    In: Biological Chemistry Vol. 401 (2020) Nr. 8, pp. 955 - 968
    Online Full Text: dx.doi.org/ (Open Access)
  • Azizan, Asma; Kaschani, Farnusch; Barinas, Hellen; Blaskowski, Svenja; Kaiser, Markus; Denecke, Martin
    Using proteomics for an insight into the performance of activated sludge in a lab-scale WWTP
    In: International Biodeterioration & Biodegradation Vol. 149 (2020) pp. 104934
    Online Full Text: dx.doi.org/
  • Krahn, Daniel; Heilmann, Geronimo; Vogel, Felix C. E.; Papadopoulos, Chrisovalantis; Zweerink, Susanne; Kaschani, Farnusch; Meyer, Hemmo; Rösch, Alexander; Kaiser, Markus
    Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family
    In: Chemistry - A European Journal Vol. 26 (2020) Nr. 39, pp. 8524 - 8531
    Online Full Text: dx.doi.org/ (Open Access)
  • Kourelis, Jiorgos; Kaschani, Farnusch; Grosse-Holz, Friederike M.; Homma, Felix; Kaiser, Markus; van der Hoorn, Renier A. L.
    A homology-guided, genome-based proteome for improved proteomics in the alloploid Nicotiana benthamiana
    In: BMC Genomics Vol. 20 (2019) Nr. 1, pp. 722
    Online Full Text: dx.doi.org/ (Open Access)
  • Jutras, Philippe V.; Grosse-Holz, Friederike; Kaschani, Farnusch; Kaiser, Markus; Michaud, Dominique; Hoorn, Renier A. L. van der
    Activity-based proteomics reveals nine target proteases for the recombinant protein-stabilizing inhibitor S/CYS8 in Nicotiana benthamiana
    In: Plant Biotechnology Journal Vol. 17 (2019) Nr. 8, pp. 1670 - 1678
    Online Full Text: dx.doi.org/ (Open Access)
  • Weiss-Sadan, Tommy; Itzhak, Gal; Kaschani, Farnusch; Yu, Zhanru; Mahameed, Mohamed; Anaki, Adi; Ben-Nun, Yael; Merquiol, Emmanuelle; Tirosh, Boaz; Kessler, Benedikt; Kaiser, Markus; Blum, Galia
    Cathepsin L regulates metabolic networks controlling rapid cell growth and proliferation
    In: Molecular and Cellular Proteomics (MCP) Vol. 18 (2019) Nr. 7, pp. 1330 - 1344
    Online Full Text: dx.doi.org/ (Open Access)
  • Weiss-Sadan, Tommy; Maimoun, David; Oelschlagel, Diana; Kaschani, Farnusch; Misiak, Danny; Gaikwad, Hanmant; Ben-Nun, Yael; Merquiol, Emmanuelle; Anaki, Adi; Tsvirkun, Darya; Kaiser, Markus; Michl, Patrick; Gotsman, Israel; Blum, Galia
    Cathepsins Drive Anti-Inflammatory Activity by Regulating Autophagy and Mitochondrial Dynamics in Macrophage Foam Cells
    In: Cellular Physiology and Biochemistry Vol. 53 (2019) Nr. 3, pp. 550 - 572
    Online Full Text: dx.doi.org/ (Open Access)
  • Viñegra de la Torre, Natanael; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A L; Soppe, Wim J J; Misas Villamil, Johana C.
    Dynamic hydrolase labelling as a marker for seed quality in Arabidopsis seeds
    In: Biochemical Journal Vol. 476 (2019) Nr. 5, pp. 843 - 857
    Online Full Text: dx.doi.org/ (Open Access)
  • Buscaill, Pierre; Chandrasekar, Balakumaran; Sanguankiattichai, Nattapong; Kourelis, Jiorgos; Kaschani, Farnusch; Thomas, Emma L.; Morimoto, Kyoko; Kaiser, Markus; Preston, Gail M.; Ichinose, Yuki; Van Der Hoorn, Renier A.L.
    Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptides
    In: Science Vol. 364 (2019) Nr. 6436, eaav0748
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Kraiselburd, Ivana; Brüls, Thomas; Heilmann, Geronimo; Kaschani, Farnusch; Kaiser, Markus; Meckenstock, Rainer
    Metabolic reconstruction of the genome of candidate Desulfatiglans TRIP_1 and identification of key candidate enzymes for anaerobic phenanthrene degradation
    In: Environmental Microbiology Vol. 21 (2019) Nr. 4, pp. 1267 - 1286
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Halder, Vivek; Suliman, Mohamed N S; Kaschani, Farnusch; Kaiser, Markus
    Plant chemical genetics reveals colistin sulphate as a SA and NPR1-independent PR1 inducer functioning via a p38-like kinase pathway
    In: Scientific Reports Vol. 9 (2019) Nr. 1, pp. 11196
    Online Full Text: dx.doi.org/ (Open Access)
  • Schulze Hüynck, Jan; Kaschani, Farnusch; van der Linde, Karina; Ziemann, Sebastian; Müller, André N.; Colby, Thomas; Kaiser, Markus; Misas Villamil, Johana C.; Doehlemann, Gunther
    Proteases underground : Analysis of the maize root apoplast identifies organ specific papain-like cysteine protease activity
    In: Frontiers in Plant Science (FPLS) Vol. 10 (2019)
    Online Full Text: dx.doi.org/ (Open Access)
  • Morimoto, Kyoko; Cole, Kyle S.; Kourelis, Jiorgos; Witt, Collin H.; Brown, Daniel; Krahn, Daniel; Stegmann, Monika; Kaschani, Farnusch; Kaiser, Markus; Burton, Jonathan; Mohammed, Shabaz; Yamaguchi-Shinozaki, Kazuko; Weerapana, Eranthie; van der Hoorn, Renier A. L.
    Triazine probes target ascorbate peroxidases in plants
    In: Plant Physiology Vol. 180 (2019) Nr. 4, pp. 1848 - 1859
    Online Full Text: dx.doi.org/ (Open Access)
  • Pöhler, Robert; Krahn, Jan; van den Boom, Johannes; Dobrynin, Grzegorz; Kaschani, Farnusch; Eggenweiler, Hans-Michael; Zenke, Frank T.; Kaiser, Markus; Meyer, Hemmo
    A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases
    In: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 6, pp. 1576 - 1580
    Online Full Text: dx.doi.org/
  • Ziemann, Sebastian; Van Der Linde, Karina; Lahrmann, Urs; Acar, Beyda; Kaschani, Farnusch; Colby, Tom; Kaiser, Markus; Ding, Yezhang; Schmelz, Eric; Huffaker, Alisa; Holton, Nicholas; Zipfel, Cyril; Doehlemann, Gunther
    An apoplastic peptide activates salicylic acid signalling in maize
    In: Nature Plants Vol. 4 (2018) Nr. 3, pp. 172 - 180
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Dong, Xiyang; Greening, Chris; Brüls, Thomas; Conrad, Ralf; Guo, Kun; Blaskowski, Svenja; Kaschani, Farnusch; Kaiser, Markus; Abu Laban, Nidal; Meckenstock, Rainer
    Fermentative Spirochaetes mediate necromass recycling in anoxic hydrocarbon-contaminated habitats
    In: ISME Journal Vol. 12 (2018) Nr. 8, pp. 2039 - 2050
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Schillinger, Jasmin; Severin, Katharina; Kaschani, Farnusch; Kaiser, Markus; Ehrmann, Michael
    HTRA1-Dependent Cell Cycle Proteomics
    In: Journal of Proteome Research Vol. 17 (2018) Nr. 8, pp. 2679 - 2694
    Online Full Text: dx.doi.org/
  • Bongard, Jens; Lorenz, Marian; Vetter, Ingrid R.; Stege, Patricia; Porfetye, Arthur T.; Schmitz, Anna Laura; Kaschani, Farnusch; Wolf, Alex; Koch, Uwe; Nussbaumer, Peter; Klebl, Bert; Kaiser, Markus; Ehrmann, Michael
    Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent Probes
    In: ACS Chemical Biology Vol. 13 (2018) Nr. 5, pp. 1307 - 1312
    Online Full Text: dx.doi.org/
  • Halder, Vivek; Oeljeklaus, Julian; Heilmann, Geronimo; Krahn, Jan; Liu, Yanlin; Xiong, Yan; Schlicht, Markus; Schillinger, Jasmin; Kracher, Barbara; Ehrmann, Michael; Kombrink, Erich; Kaschani, Farnusch; Kaiser, Markus
    Identification of the Natural Product RotihibinA as a TOR Kinase Signaling Inhibitor by Unbiased Transcriptional Profiling
    In: Chemistry - A European Journal Vol. 24 (2018) Nr. 48, pp. 12500 - 12504
    Online Full Text: dx.doi.org/
  • Santos, Rita B.; Chandrasekar, Balakumaran; Mandal, Manoj K.; Kaschani, Farnusch; Kaiser, Markus; Both, Leonard; van der Hoorn, Renier A. L.; Schiermeyer, Andreas; Abranches, Rita
    Low Protease Content in Medicago truncatula Cell Cultures Facilitates Recombinant Protein Production
    In: Biotechnology Journal Vol. 13 (2018) Nr. 7, 1800050
    Online Full Text: dx.doi.org/
  • Husaini, Amjad M; Morimoto, Kyoko; Chandrasekar, Balakumaran; Kelly, Steven; Kaschani, Farnusch; Palmero, Daniel; Jiang, Jianbing; Kaiser, Markus; Ahrazem, Oussama; Overkleeft, Hermen S; van der Hoorn, Renier A L
    Multiplex Fluorescent, Activity-Based Protein Profiling Identifies Active α-Glycosidases and Other Hydrolases in Plants
    In: Plant Physiology Vol. 177 (2018) Nr. 1, pp. 24 - 37
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Planas-Marquès, Marc; Bernardo-Faura, Martí; Paulus, Judith; Kaschani, Farnusch; Kaiser, Markus; Valls, Marc; Van Der Hoorn, Renier A. L.; Coll, Núria S.
    Protease Activities Triggered by Ralstonia solanacearum Infection in Susceptible and Tolerant Tomato Lines
    In: Molecular and Cellular Proteomics (MCP) Vol. 17 (2018) Nr. 6, pp. 1112 - 1125
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Grosse-Holz, Friederike; Kelly, Steven; Blaskowski, Svenja; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A.L.
    The transcriptome, extracellular proteome and active secretome of agroinfiltrated Nicotiana benthamiana uncover a large, diverse protease repertoire
    In: Plant Biotechnology Journal Vol. 16 (2018) Nr. 5, pp. 1068 - 1084
    Online Full Text: dx.doi.org/ (Open Access)
  • Grosse-Holz, Friederike; Madeira, Luisa; Zahid, Muhammad Awais; Songer, Molly; Kourelis, Jiorgos; Fesenko, Mary; Ninck, Sabrina; Kaschani, Farnusch; Kaiser, Markus; van der Hoorn, Renier A.L.
    Three unrelated protease inhibitors enhance accumulation of pharmaceutical recombinant proteins in Nicotiana benthamiana
    In: Plant Biotechnology Journal Vol. 16 (2018) Nr. 10, pp. 1797 - 1810
    Online Full Text: dx.doi.org/ (Open Access)
  • Weith, Matthias; Seiler, Jonas; van den Boom, Johannes; Kracht, Matthias; Hülsmann, Julia; Primorac, Ivana; Del Pino Garcia, Javier; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Bollen, Mathieu; Meyer, Hemmo
    Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation
    In: Molecular Cell Vol. 72 (2018) Nr. 4, pp. 766 - 777
    Online Full Text: dx.doi.org/ (Open Access)
  • Bravo-Rodriguez, Kenny; Hagemeier, Birte; Drescher, Lea; Lorenz, Marian; Rey, Juliana; Meltzer, Michael; Kaschani, Farnusch; Kaiser, Markus; Ehrmann, Michael
    Utilities for Mass Spectrometry Analysis of Proteins (UMSAP) : Fast post-processing of mass spectrometry data
    In: Rapid Communications in Mass Spectrometry Vol. 32 (2018) Nr. 19, pp. 1659 - 1667
    Online Full Text: dx.doi.org/
  • Zweerink, Susanne; Kallnik, Verena; Ninck, Sabrina; Nickel, Sabrina; Verheyen, Julia; Blum, Marcel; Wagner, Alexander; Feldmann, Ingo; Sickmann, Albert; Albers, Sonja-Verena; Bräsen, Christopher; Kaschani, Farnusch; Siebers, Bettina; Kaiser, Markus
    Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic Archaea
    In: Nature Communications Vol. 8 (2017) pp. 15352
    Online Full Text: dx.doi.org/ (Open Access)
  • Klein, Diana; Steens, Jennifer; Wiesemann, Alina; Schulz, Florian; Kaschani, Farnusch; Röck, Katharina; Yamaguchi, Masahiro; Wirsdörfer, Florian; Kaiser, Markus; Fischer, Jens W.; Stuschke, Martin; Jendrossek, Verena
    Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expression
    In: Antioxidants and Redox Signaling Vol. 26 (2017) Nr. 11, pp. 563 - 582
    Online Full Text: dx.doi.org/ (Open Access)
  • Kovács, Judit; Poór, Péter; Kaschani, Farnusch; Chandrasekar, Balakumaran; Hong, Tram N.; Misas-Villamil, Johana C.; Xin, Bo T.; Kaiser, Markus; Overkleeft, Herman S.; Tari, Irma; van der Hoorn, Renier A. L.
    Proteasome activity profiling uncovers alteration of catalytic β2 and β5 subunits of the stress-induced proteasome during salinity stress in tomato roots
    In: Frontiers in Plant Science (FPLS) Vol. 8 (2017) 107
    Online Full Text: dx.doi.org/ (Open Access)
  • Beisser, Daniela; Kaschani, Farnusch; Graupner, Nadine; Großmann, Lars; Jensen, Manfred; Ninck, Sabrina; Schulz, Florian; Rahmann, Sven; Boenigk, Jens; Kaiser, Markus
    Quantitative proteomics reveals ecophysiological effects of light and silver stress on the mixotrophic protist Poterioochromonas malhamensis
    In: PLoS ONE Vol. 12 (2017) Nr. 1, pp. e0168183
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Misas-Villamil, Johana C.; van der Burgh, Aranka M.; Grosse-Holz, Friederike; Bach-Pages, Marcel; Kovács, Judit; Kaschani, Farnusch; Schilasky, Sören; Emon, Asif E.K.; Ruben, Mark; Kaiser, Markus; Overkleeft, Hermen S.; van der Hoorn, Renier A.L.
    Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections
    In: The Plant Journal Vol. 90 (2017) Nr. 2, pp. 418 - 430
    Online Full Text: dx.doi.org/
  • De Montaigu, Amaury; Oeljeklaus, Julian; Krahn, Jan; Suliman, Mohamed N.S.; Halder, Vivek; De Ansorena, Elisa; Nickel, Sabrina; Schlicht, Markus; Plíhal, Ondřej; Kubiasová, Karolina; Radová, Lenka; Kracher, Barbara; Tóth, Réka; Kaschani, Farnusch; Coupland, George; Kombrink, Erich; Kaiser, Markus
    The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock
    In: ACS Chemical Biology Vol. 12 (2017) Nr. 6, pp. 1466 - 1471
    Online Full Text: dx.doi.org/ (Open Access)
  • Krahn, Jan; Kaschani, Farnusch; Kaiser, Markus
    Turning-ON Proteasomes
    In: Cell Chemical Biology Vol. 24 (2017) Nr. 6, pp. 653 - 655
    Online Full Text: dx.doi.org/
  • Shaulov-Rotem, Yulia; Merquiol, Emmanuelle; Weiss-Sadan, Tommy; Moshel, Ofra; Salpeter, Seth; Shabat, Doron; Kaschani, Farnusch; Kaiser, Markus; Blum, Galia
    A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosis
    In: Chemical Science Vol. 7 (2016) pp. 1322 - 1337
    Online Full Text: dx.doi.org/ (Open Access)
  • Kaschani, Farnusch; Wei, Quing; Dingemans, Jozef; van der Hoorn, Renier A.L.; Cornelis, Pierre; Kaiser, Markus
    Capture of endogenously biotinylated proteins from Pseudomonas aeruginosa displays unexpected downregulation of LiuD upon iron nutrition
    In: Bioorganic and Medicinal Chemistry Vol. 24 (2016) Nr. 15, pp. 3330 - 3335
    Online Full Text: dx.doi.org/
  • Shindo, Takayuki; Kaschani, Farnusch; Yang, Fan; Kovács, Judit; Tian, Fang; Kourelis, Jiorgos; Hong, Tram Ngoc; Colby, Tom; Shabab, Mohammed; Chawla, Rohini; Kumari, Selva; Ilyas, Muhammad; Hörger, Anja C.; Alfano, James R.; van der Hoorn, Renier A. L.
    Screen of Non-annotated Small Secreted Proteins of Pseudomonas syringae Reveals a Virulence Factor That Inhibits Tomato Immune Proteases
    In: PLoS Pathogens Vol. 12 (2016) Nr. 9, pp. 1005874
    Online Full Text: dx.doi.org/ (Open Access)
  • van den Boom, Johannes; Wolf, Markus; Weimann, Lena; Schulze, Nina; Li, Fanghua; Kaschani, Farnusch; Riemer, Anne; Zierhut, Christian; Kaiser, Markus; Iliakis, George; Funabiki, Hironori; Meyer, Hemmo
    VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair
    In: Molecular Cell Vol. 64 (2016) Nr. 1, pp. 189 - 198
    Online Full Text: dx.doi.org/ (Open Access)
  • Ehrmann, Michael; Kaschani, Farnusch; Kaiser, Markus
    Chemical proteomics versus Leishmaniasis
    In: Chemistry and Biology Vol. 22 (2015) Nr. 3, pp. 309 - 310
    Online Full Text: dx.doi.org/ (Open Access)
  • Nickel, Sabrina; Serwa, Remigiusz A.; Kaschani, Farnusch; Ninck, Sabrina; Zweerink, Susanne; Tate, Edward W.; Kaiser, Markus
    Chemoproteomic Evaluation of the Polyacetylene Callyspongynic Acid
    In: Chemistry - A European Journal Vol. 21 (2015) Nr. 30, pp. 10721 - 10728
    Online Full Text: dx.doi.org/ (Open Access)
  • Poepsel, Simon; Sprengel, Andreas; Sacca, Barbara; Kaschani, Farnusch; Kaiser, Markus; Gatsogiannis, Christos; Raunser, Stefan; Clausen, Tim; Ehrmann, Michael
    Determinants of amyloid fibril degradation by the PDZ protease HTRA1
    In: Nature Chemical Biology Vol. 11 (2015) Nr. 11, pp. 862 - 869
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Ilyas, Muhammad; Hörger, Anja C.; Bozkurt, Tolga O.; Burg, Harrold A. van den; Kaschani, Farnusch; Kaiser, Markus; Belhaj, Khaoula; Smoker, Matthew; Joosten, Matthieu H. A. J.; Kamoun, Sophien; Hoorn, Renier A. L. van der
    Functional divergence of two secreted immune proteases of tomato
    In: Current Biology Vol. 25 (2015) Nr. 17, pp. 2300 - 2306
    Online Full Text: dx.doi.org/ (Open Access)