ZMB Member Farnusch Kaschani

ZMB Member
Farnusch Kaschani

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portrait photo of ZMB member Farnusch Kaschani
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Dr. Farnusch Kaschani

Group Chemical Proteomics

Analytics Core Facility Essen (ACE)

Center of Medical Biotechnology (ZMB)
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

Research Overview

The Analytics Core Facility Essen (ACE) is a central facility of the Center of Medical Biotechnology (ZMB) and of the Faculty of Biology of the University Duisburg-Essen. It offers access to state-of-the-art mass spectrometry-based proteomics for internal and external users. The timely technical equipment of the ACE allows us to provide a wide variety of different “bottom-up” and “top-down” proteomics methods. Furthermore, we also develop innovative solutions for project-specific demands. The service comprises all aspects of mass spectrometry-based proteomics, starting from technical advice and project planning, sample preparation and analysis to data analysis, data management and interpretation of results. We are also listed in the RIsources Poral of the DFG (RI_00466).
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Selected Publications

    Journal articles

  • Day, Matthew; Tetik, Bilal; Parlak, Milena; Almeida-Hernández, Yasser; Räschle, Markus; Kaschani, Farnusch; Siegert, Heike; Marko, Anika; Sanchez-Garcia, Elsa; Kaiser, Markus; Barker, Isabel A.; Pearl, Laurence H.; Oliver, Antony W.; Boos, Dominik
    TopBP1 utilises a bipartite GINS binding mode to support genome replication
    In: Nature Communications Vol. 15 (2024) Nr. 1, 1797
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Hoi, David M.; Junker, Sabryna; Junk, Lukas; Schwechel, Kristin; Fischel, Katharina; Podlesainski, David; Hawkins, Paige M.E.; van Geelen, Lasse; Kaschani, Farnusch; Leodolter, Julia; Morreale, Francesca Ester; Kleine, Stefan; Guha, Somraj; Rumpel, Klaus; Schmiedel, Volker M.; Weinstabl, Harald; Meinhart, Anton; Payne, Richard J.; Kaiser, Markus; Hartl, Markus; Boehmelt, Guido; Kazmaier, Uli; Kalscheuer, Rainer; Clausen, Tim
    Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival
    In: Cell Vol. 186 (2023) Nr. 10, pp. 2176 - 2192.e22
    Online Full Text: dx.doi.org/ (Open Access)
  • Rüttermann, Maximilian; Koci, Michelle; Lill, Pascal; Geladas, Ermis Dionysios; Kaschani, Farnusch; Klink, Björn Udo; Erdmann, Ralf; Gatsogiannis, Christos
    Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate
    In: Nature Communications Vol. 14 (2023) Nr. 1, 5942
    Online Full Text: dx.doi.org/ (Open Access)
  • Blüggel, Mike; Kröning, Alexander; Kracht, Matthias; van den Boom, Johannes; Dabisch, Matthias; Göhring, Anna; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter; Meyer, Hemmo; Beuck, Christine
    The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase
    In: Nature Communications Vol. 14 (2023) Nr. 1, 3258
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander
    Persister state-directed transitioning and vulnerability in melanoma
    In: Nature Communications Vol. 13 (2022) Nr. 1, 3055
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Pöhler, Robert; Krahn, Jan; van den Boom, Johannes; Dobrynin, Grzegorz; Kaschani, Farnusch; Eggenweiler, Hans-Michael; Zenke, Frank T.; Kaiser, Markus; Meyer, Hemmo
    A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases
    In: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 6, pp. 1576 - 1580
    Online Full Text: dx.doi.org/
  • Ziemann, Sebastian; Van Der Linde, Karina; Lahrmann, Urs; Acar, Beyda; Kaschani, Farnusch; Colby, Tom; Kaiser, Markus; Ding, Yezhang; Schmelz, Eric; Huffaker, Alisa; Holton, Nicholas; Zipfel, Cyril; Doehlemann, Gunther
    An apoplastic peptide activates salicylic acid signalling in maize
    In: Nature Plants Vol. 4 (2018) Nr. 3, pp. 172 - 180
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Weith, Matthias; Seiler, Jonas; van den Boom, Johannes; Kracht, Matthias; Hülsmann, Julia; Primorac, Ivana; Del Pino Garcia, Javier; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Bollen, Mathieu; Meyer, Hemmo
    Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation
    In: Molecular Cell Vol. 72 (2018) Nr. 4, pp. 766 - 777
    Online Full Text: dx.doi.org/ (Open Access)
  • Zweerink, Susanne; Kallnik, Verena; Ninck, Sabrina; Nickel, Sabrina; Verheyen, Julia; Blum, Marcel; Wagner, Alexander; Feldmann, Ingo; Sickmann, Albert; Albers, Sonja-Verena; Bräsen, Christopher; Kaschani, Farnusch; Siebers, Bettina; Kaiser, Markus
    Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic Archaea
    In: Nature Communications Vol. 8 (2017) pp. 15352
    Online Full Text: dx.doi.org/ (Open Access)
  • van den Boom, Johannes; Wolf, Markus; Weimann, Lena; Schulze, Nina; Li, Fanghua; Kaschani, Farnusch; Riemer, Anne; Zierhut, Christian; Kaiser, Markus; Iliakis, George; Funabiki, Hironori; Meyer, Hemmo
    VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair
    In: Molecular Cell Vol. 64 (2016) Nr. 1, pp. 189 - 198
    Online Full Text: dx.doi.org/ (Open Access)
  • Poepsel, Simon; Sprengel, Andreas; Sacca, Barbara; Kaschani, Farnusch; Kaiser, Markus; Gatsogiannis, Christos; Raunser, Stefan; Clausen, Tim; Ehrmann, Michael
    Determinants of amyloid fibril degradation by the PDZ protease HTRA1
    In: Nature Chemical Biology Vol. 11 (2015) Nr. 11, pp. 862 - 869
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Oeljeklaus, Julian; Kaschani, Farnusch; Kaiser, Markus
    Streamlining chemical probe discovery : libraries of "fully functionalized" small molecules for phenotypic screening
    In: Angewandte Chemie International Edition Vol. 52 (2013) Nr. 5, pp. 1368 - 1370
    Online Full Text: dx.doi.org/
  • Kaschani, Farnusch; Clerc, Jérôme; Krahn, Daniel; Bier, David; Hong, Tram Ngoc; Ottmann, Christian; Niessen, Sherry; Colby, Tom; Van Der Hoorn, Renier A. L.; Kaiser, Markus; van der Hoorn, Renier A. L.
    Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenases
    In: Angewandte Chemie International Edition Vol. 51 (2012) Nr. 21, pp. 5230 - 5233
    Online Full Text: dx.doi.org/

Curriculum Vitae

Professional appointments  
Since 2013 Group leader “Chemical Proteomics”, University of Duisburg-Essen, Germany.

Head of Analytics Core Facility (ACE), University of Duisburg-Essen, Germany
2011–2012 Lab-manager and Senior Postdoc in the group of Prof. Kaiser at the University of Duisburg-Essen. Responsible for proteomics and target identification as well as laboratory management.
2006–2011 Senior Postdoc in the Plant Chemetics Lab of Dr. Renier van der Hoorn at the Max-Planck-Institute for Plant Breeding Research in Cologne.
Academic degrees  
2001 - 2005 PhD thesis at the Max-Planck-Institute for Plant Breeding Research in Cologne in the department of Prof. Heinz Saedler
1995 - 2000 Study of Chemistry at the Julius Maximilians-Universität Würzburg and at the Queensland University of Technology (QUT) in Brisbane, Australia.
Honours  
2012 Grant of the rectorate of the University Duisburg-Essen ("Rektoratsprogramm zur Förderung des wissenschaftlichen Nachwuchses", 01.08.2012 - 30.09.2013 25000€).

Poster Price of the International Biometals society for best Poster presented at the 8th International Symposium on Biometals in Brussels Belgium

Travel grant from the DAAD to attend the 8th International Symposium on Biometals in Brussels Belgium (15.-19.07.2012). The grant covered all travelling costs and registration fees.

2009 Travel grant from the DAAD to attend the IV International Symposium on Biochemistry and Molecular Biology, Havana, Cuba (12.-16.10.2009). The grant covered all travelling costs and registration fees.

Travel grant from the New Phytologist Trust to attend the 22th New Phytologist Symposium on Effectors in Plant-microbe interactions, Paris, France (13.-16.09.2009). The grant covered all travelling costs and registration fees.