P6: targeting trained immunity

Trained immunity in cardiac cells

Immune activation and inflammation characterize repAMI. DAMPs can induce trained immunity in some non-immune cells through epigenetic, transcriptional and metabolic reprogramming. This primes cells for a stronger response to subsequent inflammatory triggers. Although, simulated I/R evokes epigenetic modifications in vitro, development of immune memory in cardiac cells in the setting of repAMI has not yet been reported.

 

Objectives

Therefore, the project aims for the dissection of mechanisms and consequences of transcriptional, metabolic and epigenetic remodeling in cardiac cells in repAMI. Specific objectives are:

  • RepAMI-triggered immune training of cardiac cells and the impact on post-infarct inflammation and resolution
  • Spatial and cellular context of immune remodeling
  • Validation of druggable candidates in translational models

​P6_1
MultiOmics and spatial imaging in cells and tissues
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​P6_2
Multiplex immunofluorescence analysis of repAMI​

 

Principal Investigators

​Siveke_Hendgen-Cotta

 

If you are interested in joining this project, please see our available positions here.​