P2: targeting cardiac macrophages

Targeting cardiac tissue-resident and monocyte-derived macrophages

Tissue-resident cardiac macrophages (MΦ) play essential roles in tissue repair, regeneration, and fibrosis in response to repAMI. However, inflammatory-recruited monocyte and MΦ populations are not well defined yet. Moreover, it is unclear which influence the microenvironment exerts on cell polarization and function. Niche-specific infiltration of different MΦ population profiles is also being investigated from the perspective of the impact of the MΦ migration inhibitory factor (MIF).

 

Objectives

  • Which MΦ populations are recruited to which inflammatory niches?
  • What are the individual underlying recruitment and polarization mechanisms?
  • How do the individual MΦ populations and their modulation via MIF affect tissue repair mechanisms in repAMI?
  • How does the fibroblast-like phenotype-switch affect MΦ-dependent repair mechanisms after repAMI?

​P2_1
Niche-specific MΦ subsets in repAMI
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Principal Investigators

​Grueneboom_Totzeck​

 

PhD & MD Candidates

M.Sc. Nora Pauly (PhD Candidate 1st PhD Cohort)

M.Sc. Franziska Sackel (PhD Candidate 2nd PhD Cohort)

Elizaveta Turshatova (MD Candidate)

 

If you are interested in joining this project, please see our available here.

This project is located at the Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. in Dortmund.​

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