P2: targeting cardiac macrophages

Targeting cardiac tissue-resident and monocyte-derived macrophages

Tissue-resident cardiac macrophages (MΦ) play essential roles in tissue repair, regeneration, and fibrosis in response to repAMI. However, inflammatory-recruited monocyte and MΦ populations are not well defined yet. Moreover, it is unclear which influence the microenvironment exerts on cell polarization and function. Niche-specific infiltration of different MΦ population profiles is also being investigated from the perspective of the impact of the MΦ migration inhibitory factor (MIF).

 

Objectives

  • Which MΦ populations are recruited to which inflammatory niches?
  • What are the individual underlying recruitment and polarization mechanisms?
  • How do the individual MΦ populations and their modulation via MIF affect tissue repair mechanisms in repAMI?
  • How does the fibroblast-like phenotype-switch affect MΦ-dependent repair mechanisms after repAMI?

​P2_1
Niche-specific MΦ subsets in repAMI
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Principal Investigators

​Grueneboom_Totzeck​

 

This project is located at the Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. in Dortmund.​

If you are interested in joining this project, please see our available here.