P5: targeting extracellular vesicles

Signal transfer of RIC in patients undergoing coronary artery bypass grafting

​Remote Ischemic Conditioning (RIC)  by  brief  episodes  of  I/R  in  limbs  before  sustained  myocardial  I/R  is  a  non-invasive  strategy  protecting  the  myocardium from  irreversible  I/R  injury  in  patients  undergoing interventional  or  surgical coronary  revascularization.  

P5_1


Objectives

Gathering a more detailed understanding of RIC to optimize it application in clinical practice. Specific objectives are:

  • To identify RIC´s signal transduction from the periphery to the heart
  • To charactized RIC´s signaling within the myocardium (vasculature vs. cardiomyocytes)
  • To assess RIC´s impact on coronary vasomotion/coronary microvascular obstruction

​P5_2
RIC´s cardioprotective signal from the periphery to the heart

 

Principal Investigators

​Kleinbongard_Kamler

 

PhD & MD Candidates

M.Sc. Michelle Alff (PhD Candidate 1st PhD Cohort)

M.Sc. Johanna Albrecht (PhD Candidate 2nd Cohort)

Kevin Kurnikov (MD Candidate)

Jannick Haide (MD Candidate)

Xiyin Zhang (associated doctoral student)

 

If you are interested in joining this project, please see our available positions here.​

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