P5: targeting extracellular vesicles

Signal transfer of RIC in patients undergoing coronary artery bypass grafting

​Remote Ischemic Conditioning (RIC)  by  brief  episodes  of  I/R  in  limbs  before  sustained  myocardial  I/R  is  a  non-invasive  strategy  protecting  the  myocardium from  irreversible  I/R  injury  in  patients  undergoing interventional  or  surgical coronary  revascularization.  

P5_1


Objectives

Gathering a more detailed understanding of RIC to optimize it application in clinical practice. Specific objectives are:

  • To identify RIC´s signal transduction from the periphery to the heart
  • To charactized RIC´s signaling within the myocardium (vasculature vs. cardiomyocytes)
  • To assess RIC´s impact on coronary vasomotion/coronary microvascular obstruction

P5_2
RIC´s cardioprotective signal from the periphery to the heart

 

Principal Investigators

Kleinbongard_Kamler

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