If you are interested in joining this project, please see our available positions at:
https://www.uni-due.de/grk2989/opportunities.php

Dysfunctional cardiomyocyte mitochondria contribute to cardiac remodeling and left ventricular dysfunction in repAMI. Hallmarks are perturbations in substrate flux toward mitochondria, substrate utilization, and mitochondrial oxidative metabolism. Defective mitochondrial clearance in cardiomyocytes results in the accumulation of waste mitochondria and cell death. The underlying mechanisms are not fully understood, but suggest a reciprocal signaling between macrophages and cardiomyocytes affecting removal of damaged mitochondria.

To provide new insights into the mechanisms of mitochondrial remodeling and how defects in mitochondrial clearance in cardiomyocytes contribute to the final injury in repAMI. The particular objectives are:

• Spatial and temporal energetic and metabolic remodeling of cardiomyocytes
• Perturbations in substrate flux toward mitochondria, substrate utilization, and mitochondrial oxidative metabolism
• Mechanisms and regulation of cardiomyocyte mitochondrial removal 

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Spatial metabolomics and 3D imaging pipeline for mitochondrial damage
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Mitochondrial clearance in human tissue
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Principal Investigators

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