Faculty of Biology
Register of People
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Fakultät Biologie, Molekularbiologie I
Address
Universitätsstr. 2
45141 Essen
45141 Essen
Room
S03 V04 F44
Phone
Fax
E-Mail
Functions
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Professor/in, Molekularbiologie I
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Vorsitzender, Prüfungsausschuss für Medizinische Biologie
Current lectures
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2024 SS
- Zell- und Molekularbiologie
- Applied Molecular Biology
- Protein Engineering und Funktionalisierung
- (Einführung in die) Molekularbiologie (LA Ba und Bio B.Sc.); Einführung in die molekulare Zellbiologie (MolBio Bachelor)
- Übung Molekulare Zellbiologie für Molekularbiologen
- (Einführung in die) Molekularbiologie
- Group/Lab Meeting
- Molekularbiologie
- Struktur und Funktion (LA Ba) - Anmeldung mit mehreren Prioritäten
Past lectures (max. 10)
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2023 WS
- Allgemeine Methoden (Bachelor Bio)
- Molecular Cell Biology
- Allgemeine Methoden Praktikum (Bachelor Bio); Priorität für G1 oder G2
- Grundlagen der Biotechnologie (LA Ba); Platzvergabe: 3 Präferenzen angeben
- Zell- und Molekularbiologie
- Group/Lab Meeting
- ZJA91051 Molekulare Zellbiologie
- Molekulare Zellbiologie
- Allgemeine Methoden in der Molekularbiologie
- Anleitung zum wissenschaftlichen Arbeiten
The following publications are listed in the online university bibliography of the University of Duisburg-Essen. Further information may also be found on the person's personal web pages.
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Lysosomal damage sensing and lysophagy initiation by SPG20-ITCHIn: Molecular Cell (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substratesIn: Nature Communications Vol. 15 (2024) Nr. 1, 2459Online Full Text: dx.doi.org/ (Open Access)
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Structural basis of ubiquitin-independent PP1 complex disassembly by p97In: The EMBO Journal Vol. 42 (2023) Nr. 14, e113110Online Full Text: dx.doi.org/ (Open Access)
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Targeting of client proteins to the VCP/p97/Cdc48 unfolding machineIn: Frontiers in Molecular Biosciences Vol. 10 (2023) 1142989Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPaseIn: Nature Communications Vol. 14 (2023) Nr. 1, 3258Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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MAGED2 Is Required under Hypoxia for cAMP Signaling by Inhibiting MDM2-Dependent Endocytosis of G-Alpha-SIn: Cells Vol. 11 (2022) Nr. 16, 2546Online Full Text: dx.doi.org/ (Open Access)
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Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1In: Molecular Cell Vol. 82 (2022) Nr. 14, pp. 2633 - 2649.e7Online Full Text: dx.doi.org/ (Open Access)
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Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTNIn: The Journal of Biological Chemistry (JBC) Vol. 298 (2022) Nr. 6, 101976Online Full Text: dx.doi.org/ (Open Access)
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)In: Autophagy Vol. 17 (2021) Nr. 1, pp. 1 - 382Online Full Text: dx.doi.org/ (Open Access)
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Targeted substrate loop insertion by VCP/p97 during PP1 complex disassemblyIn: Nature Structural & Molecular Biology Vol. 28 (2021) Nr. 12, pp. 964 - 971Online Full Text: dx.doi.org/
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A pH-sensitive fluorescent protein sensor to follow the pathway of calcium phosphate nanoparticles into cellsIn: Acta Biomaterialia Vol. 111 (2020) pp. 406 - 417Online Full Text: dx.doi.org/
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Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain AdaptersIn: Journal of Molecular Biology (JMB) Vol. 432 (2020) Nr. 23, pp. 6061 - 6074Online Full Text: dx.doi.org/
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Regulation of lysosome integrity and lysophagy by the ubiquitin-conjugating enzyme UBE2QL1In: Autophagy Vol. 16 (2020) Nr. 1, pp. 179 - 180Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Repair or Lysophagy : Dealing with Damaged LysosomesIn: Journal of Molecular Biology (JMB) Vol. 432 (2020) Nr. 1, pp. 231 - 239Online Full Text: dx.doi.org/
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Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product FamilyIn: Chemistry - A European Journal Vol. 26 (2020) Nr. 39, pp. 8524 - 8531Online Full Text: dx.doi.org/ (Open Access)
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Structure of the PUB Domain from Ubiquitin Regulatory X Domain Protein 1 (UBXD1) and Its Interaction with the p97 AAA+ ATPaseIn: Biomolecules Vol. 9 (2019) Nr. 12, 876Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damageIn: EMBO Reports (2019) pp. e48014Online Full Text: dx.doi.org/ (Open Access)
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VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscleIn: Autophagy Vol. 15 (2019) Nr. 6, pp. 1082 - 1099Online Full Text: dx.doi.org/ (Open Access)
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A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPasesIn: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 6, pp. 1576 - 1580Online Full Text: dx.doi.org/
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AP-SWATH reveals direct involvement of VCP/ p97 in integrated stress response signaling through facilitating CReP/PPP1R15B degradationIn: Molecular and Cellular Proteomics (MCP) Vol. 17 (2018) Nr. 7, pp. 1295 - 1307Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme FormationIn: Molecular Cell Vol. 72 (2018) Nr. 4, pp. 766 - 777Online Full Text: dx.doi.org/ (Open Access)
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VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and SignalingIn: Molecular Cell Vol. 69 (2018) Nr. 2, pp. 182 - 194Online Full Text: dx.doi.org/ (Open Access)
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Delivery of the autofluorescent protein R-phycoerythrin by calcium phosphate nanoparticles into four different eukaryotic cell lines (HeLa, HEK293T, MG-63, MC3T3) : Highly efficient, but leading to endolysosomal proteolysis in HeLa and MC3T3 cellsIn: PLoS ONE Vol. 12 (2017) Nr. 6, pp. e0178260Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and LysophagyIn: Current Biology Vol. 27 (2017) Nr. 24, pp. R1330 - R1341Online Full Text: dx.doi.org/
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VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagyIn: The EMBO Journal Vol. 36 (2017) Nr. 2, pp. 135 - 150Online Full Text: dx.doi.org/ (Open Access)
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Molecular tweezers target a protein-protein interface and thereby modulate complex formationIn: Chemical Communications: ChemComm Vol. 52 (2016) Nr. 98, pp. 14141 - 14144Online Full Text: dx.doi.org/ (Open Access)
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VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break RepairIn: Molecular Cell Vol. 64 (2016) Nr. 1, pp. 189 - 198Online Full Text: dx.doi.org/ (Open Access)
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The N-terminal region of the ubiquitin regulatory X (UBX) domain-containing protein 1 (UBXD1) modulates interdomain communication within the valosin-containing protein p97In: The Journal of Biological Chemistry (JBC) Vol. 290 (2015) Nr. 49, pp. 29414 - 29427Online Full Text: dx.doi.org/ (Open Access)
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Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1In: The EMBO Journal Vol. 33 (2014) Nr. 22, pp. 2704 - 2720Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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The VCP/p97 system at a glance : connecting cellular function to disease pathogenesisIn: Journal of Cell Science Vol. 127 (2014) Nr. 18, pp. 3877 - 3883Online Full Text: dx.doi.org/
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The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradationIn: The FEBS Journal Vol. 281 (2014) Nr. Suppl. 1, pp. 82Online Full Text: dx.doi.org/
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The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradationIn: Cell Cycle Vol. 13 (2014) Nr. 6, pp. 919 - 927Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Coal mining meets chromatin research: Digging for mechanisms in epigenetic control of gene expression : Report from the 43rd Annual Meeting of the German Genetics Society on "Chromatin and Epigenetics" in Essen, GermanyIn: BioEssays Vol. 35 (2013) Nr. 2, pp. 141 - 144Online Full Text: dx.doi.org/
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The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora AIn: The Journal of Cell Biology (JCB) Vol. 201 (2013) Nr. 4, pp. 559 - 575Online Full Text: dx.doi.org/
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Ubiquitination of the n-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPaseIn: The Journal of Biological Chemistry (JBC) Vol. 288 (2013) Nr. 10, pp. 7363 - 7372Online Full Text: dx.doi.org/
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Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopyIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 109 (2012) pp. 1098 - 1103.Online Full Text: dx.doi.org/ (Open Access)
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Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin systemIn: Nature Cell Biology Vol. 14 (2012) Nr. 2, pp. 117 - 123Online Full Text: dx.doi.org/
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Expanding into new markets – VCP/p97 in endocytosis and autophagyIn: Journal of Structural Biology Vol. 179 (2012) Nr. 2, pp. 78 - 82Online Full Text: dx.doi.org/
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p97 complexes as signal integration hubsIn: BMC Biology (incorporating Journal of Biology) Vol. 10 (2012) pp. 48Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Cdc48/p97-Ufd1-Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells.In: Journal of Cell Science Vol. 124 (2011) Nr. 9, pp. 1571 - 1580Online Full Text: dx.doi.org/
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Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutationsIn: Nature Cell Biology Vol. 13 (2011) Nr. 9, pp. 1116 - 1123Online Full Text: dx.doi.org/
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The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaksIn: Nature Cell Biology Vol. 13 (2011) Nr. 11, pp. 1376 - 1382Online Full Text: dx.doi.org/
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A role for Cdc48/p97 and Aurora B in controlling chromatin condensation during exit from mitosisIn: Biochemistry and Cell Biology Vol. 88 (2010) Nr. 1, pp. 23 - 28Online Full Text: dx.doi.org/
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Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradationIn: The Journal of Cell Biology (JCB) Vol. 191 (2010) Nr. 3, pp. 615 - 629Online Full Text: dx.doi.org/
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Role(s) of Cdc48/p97 in mitosisIn: Biochemical Society Transactions Vol. 36 (2008) Nr. 1, pp. 126 - 130
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Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatinIn: Nature Vol. 450 (2007) Nr. 7173, pp. 1258
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Detailed structural insights into the p97-Npl4-Ufd1 interfaceIn: The Journal of Biological Chemistry (JBC) Vol. 282 (2007) Nr. 29, pp. 21361 - 21369
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NSF- and SNARE-mediated membrane fusion is required for nuclear envelope formation and completion of nuclear pore complex assembly in Xenopus laevis egg extractsIn: Journal of Cell Science Vol. 120 (2007) Nr. 16, pp. 2895 - 2903
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Structural insights into the p97-Ufd1-NpI4 complexIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 104 (2007) Nr. 2, pp. 467 - 472
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Golgi reassembly after mitosis : The AAA family meets the ubiquitin familyIn: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Vol. 1744 (2005) Nr. 2, pp. 108 - 119Online Full Text: dx.doi.org/ (Open Access)
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The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanismIn: The Journal of Biological Chemistry (JBC) Vol. 279 (2004) Nr. 48, pp. 49609 - 49616
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Ubiquitin Interactions of NZF Zinc FingersIn: The EMBO Journal Vol. 23 (2004) Nr. 7, pp. 1411 - 1421
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VCIP135 acts as a deubiquitinating enzyme during p97–p47-mediated reassembly of mitotic Golgi fragmentsIn: The Journal of Cell Biology (JCB) Vol. 164 (2004) Nr. 7, pp. 973 - 978
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Function of the p97–Ufd1–Npl4 complex in retrotranslocation from the ER to the cytosol : dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chainsIn: The Journal of Cell Biology (JCB) Vol. 162 (2003) Nr. 1, pp. 71 - 84Online Full Text: dx.doi.org/
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Structure and Ubiquitin Interactions of the Conserved Zinc Finger Domain of Npl4In: The Journal of Biological Chemistry (JBC) Vol. 278 (2003) pp. 20225 - 20234
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The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosisIn: Cell Vol. 115 (2003) Nr. 3, pp. 355 - 367
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Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1–Npl4In: The EMBO Journal Vol. 21 (2002) Nr. 21, pp. 5645 - 5652.
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Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assemblyIn: Nature Cell Biology Vol. 3 (2001) Nr. 12, pp. 1086 - 1091
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The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosolIn: Nature Vol. 414 (2001) pp. 652 - 656
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A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathwaysIn: The EMBO Journal Vol. 19 (2000) Nr. 10, pp. 2181 - 2192
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Structure of the AAA ATPase p97In: Molecular Cell Vol. 6 (2000) Nr. 6, pp. 1473 - 1484Online Full Text: dx.doi.org/
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The mouse p97 (CDC48) gene. Genomic structure, definition of transcriptional regulatory sequences, gene expression, and characterization of a pseudogene.In: The Journal of Biological Chemistry (JBC) Vol. 274 (1999) Nr. 15, pp. 10154 - 10162
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The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97In: FEBS Letters Vol. 437 (1998) Nr. 3, pp. 255 - 257