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Fakultät Biologie, Molekularbiologie I
Anschrift
Universitätsstr. 2
45141 Essen
45141 Essen
Raum
S03 V04 F44
Telefon
Telefax
E-Mail
Funktionen
- Professor/in, Molekularbiologie I
- Vorsitzender, Prüfungsausschuss für Medizinische Biologie
Aktuelle Veranstaltungen
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2021 SS
- Zell- und Molekularbiologie
- (Einführung in die) Molekularbiologie
- (Einführung in die) Molekularbiologie (LA Ba und Bio B.Sc.); Einführung in die molekulare Zellbiologie (MolBio Bachelor)
- Übung Molekulare Zellbiologie für Molekularbiologen
- Struktur und Funktion (LA Ba) - Anmeldung mit mehreren Prioritäten
- (LPLUS-Präsenz) Molekulare Zellbiologie
Vergangene Veranstaltungen (max. 10)
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2020 WS
- Molecular Cell Biology
- Biome - für PhD Studenten
- Allgemeine Methoden Praktikum (Bachelor Bio); Priorität für G1/G2 oder G3/4 angeben!
- Molekulare Zellbiologie
- Allgemeine Methoden (Bachelor Bio)
- Zell- und Molekularbiologie
- Grundlagen der Biotechnologie (LA Ba); Platzvergabe: 3 Präferenzen angeben
- Anleitung zum wissenschaftlichen Arbeiten
- (LPLUS-Homeoffice) Molekulare Zellbiologie
- 2020 SS
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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A pH-sensitive fluorescent protein sensor to follow the pathway of calcium phosphate nanoparticles into cellsIn: Acta Biomaterialia Jg. 111 (2020) S. 406 - 417
ISSN: 1878-7568; 1742-7061Online Volltext: dx.doi.org/ -
Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain AdaptersIn: Journal of Molecular Biology: JMB Jg. 432 (2020) Nr. 23, S. 6061 - 6074
ISSN: 1089-8638; 0022-2836Online Volltext: dx.doi.org/ -
Regulation of lysosome integrity and lysophagy by the ubiquitin-conjugating enzyme UBE2QL1In: Autophagy Jg. 16 (2020) Nr. 1, S. 179 - 180
ISSN: 1554-8627; 1554-8635Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
Repair or Lysophagy : Dealing with Damaged LysosomesIn: Journal of Molecular Biology Jg. 432 (2020) Nr. 1, S. 231 - 239
ISSN: 1089-8638; 0022-2836Online Volltext: dx.doi.org/ -
Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product FamilyIn: Chemistry: A European Journal Jg. 26 (2020) Nr. 39, S. 8524 - 8531
ISSN: 1521-3765; 0947-6539Online Volltext: dx.doi.org/ (Open Access) -
Structure of the PUB Domain from Ubiquitin Regulatory X Domain Protein 1 (UBXD1) and Its Interaction with the p97 AAA+ ATPaseIn: Biomolecules Jg. 9 (2019) Nr. 12, S. 876
ISSN: 2218-273XOnline Volltext: dx.doi.org/ Online Volltext (Open Access) -
The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damageIn: EMBO Reports (2019) S. e48014
ISSN: 1469-3178; 1469-221XOnline Volltext: dx.doi.org/ (Open Access) -
VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscleIn: Autophagy Jg. 15 (2019) Nr. 6, S. 1082 - 1099
ISSN: 1554-8635; 1554-8627Online Volltext: dx.doi.org/ -
A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPasesIn: Angewandte Chemie International Edition Jg. 57 (2018) Nr. 6, S. 1576 - 1580
ISSN: 1521-3773; 1433-7851; 0570-0833Online Volltext: dx.doi.org/ -
AP-SWATH reveals direct involvement of VCP/ p97 in integrated stress response signaling through facilitating CReP/PPP1R15B degradationIn: Molecular and Cellular Proteomics Jg. 17 (2018) Nr. 7, S. 1295 - 1307
ISSN: 1535-9484; 1535-9476Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme FormationIn: Molecular Cell Jg. 72 (2018) Nr. 4, S. 766 - 777
ISSN: 1097-2765; 1097-4164Online Volltext: dx.doi.org/ (Open Access) -
VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and SignalingIn: Molecular Cell Jg. 69 (2018) Nr. 2, S. 182 - 194
ISSN: 1097-4164; 1097-2765Online Volltext: dx.doi.org/ (Open Access) -
Delivery of the autofluorescent protein R-phycoerythrin by calcium phosphate nanoparticles into four different eukaryotic cell lines (HeLa, HEK293T, MG-63, MC3T3) : Highly efficient, but leading to endolysosomal proteolysis in HeLa and MC3T3 cellsIn: PLoS ONE Jg. 12 (2017) Nr. 6, S. e0178260
ISSN: 1932-6203Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and LysophagyIn: Current Biology Jg. 27 (2017) Nr. 24, S. R1330 - R1341
ISSN: 0960-9822; 1879-0445Online Volltext: dx.doi.org/ -
VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagyIn: The EMBO Journal Jg. 36 (2017) Nr. 2, S. 135 - 150
ISSN: 1460-2075; 0261-4189Online Volltext: dx.doi.org/ (Open Access) -
Molecular tweezers target a protein-protein interface and thereby modulate complex formationIn: Chemical Communications Jg. 52 (2016) Nr. 98, S. 14141 - 14144
ISSN: 1364-548X; 0009-241X; 0022-4936; 1359-7345Online Volltext: dx.doi.org/ (Open Access) -
VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break RepairIn: Molecular Cell Jg. 64 (2016) Nr. 1, S. 189 - 198
ISSN: 1097-4164; 1097-2765Online Volltext: dx.doi.org/ (Open Access) -
The N-terminal region of the ubiquitin regulatory X (UBX) domain-containing protein 1 (UBXD1) modulates interdomain communication within the valosin-containing protein p97In: Journal of Biological Chemistry Jg. 290 (2015) Nr. 49, S. 29414 - 29427
ISSN: 0021-9258; 1083-351XOnline Volltext: dx.doi.org/ (Open Access) -
Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1In: The EMBO Journal Jg. 33 (2014) Nr. 22, S. 2704 - 2720
ISSN: 0261-4189; 1460-2075Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
The VCP/p97 system at a glance : connecting cellular function to disease pathogenesisIn: Journal of Cell Science Jg. 127 (2014) Nr. 18, S. 3877 - 3883
ISSN: 0021-9533; 1477-9137; 0370-2952Online Volltext: dx.doi.org/ -
The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradationIn: The FEBS Journal Jg. 281 (2014) Nr. Suppl. 1, S. 82
ISSN: 1742-4658; 1742-464XOnline Volltext: dx.doi.org/ -
The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradationIn: Cell Cycle Jg. 13 (2014) Nr. 6, S. 919 - 927
ISSN: 1551-4005Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
Coal mining meets chromatin research: Digging for mechanisms in epigenetic control of gene expression : Report from the 43rd Annual Meeting of the German Genetics Society on "Chromatin and Epigenetics" in Essen, GermanyIn: BioEssays Jg. 35 (2013) Nr. 2, S. 141 - 144
ISSN: 0265-9247; 1521-1878Online Volltext: dx.doi.org/ -
The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora AIn: The Journal of Cell Biology Jg. 201 (2013) Nr. 4, S. 559 - 575
ISSN: 1540-8140; 0021-9525Online Volltext: dx.doi.org/ -
Ubiquitination of the n-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPaseIn: Journal of Biological Chemistry Jg. 288 (2013) Nr. 10, S. 7363 - 7372
ISSN: 0021-9258; 1083-351XOnline Volltext: dx.doi.org/ -
Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopyIn: Proceedings of the National Academy of Sciences of the United States of America Jg. 109 (2012) S. 1098 - 1103.
ISSN: 1091-6490; 0027-8424Online Volltext: dx.doi.org/ (Open Access) -
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin systemIn: Nature Cell Biology Jg. 14 (2012) Nr. 2, S. 117 - 123
ISSN: 1465-7392Online Volltext: dx.doi.org/ -
Expanding into new markets – VCP/p97 in endocytosis and autophagyIn: Journal of Structural Biology Jg. 179 (2012) Nr. 2, S. 78 - 82
ISSN: 1095-8657; 1047-8477Online Volltext: dx.doi.org/ -
p97 complexes as signal integration hubsIn: BMC Biology (incorporating Journal of Biology) Jg. 10 (2012) S. 48
ISSN: 1741-7007Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
Cdc48/p97-Ufd1-Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells.In: Journal of Cell Science Jg. 124 (2011) Nr. 9, S. 1571 - 1580
ISSN: 0021-9533; 1477-9137; 0370-2952Online Volltext: dx.doi.org/ -
Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutationsIn: Nature Cell Biology Jg. 13 (2011) Nr. 9, S. 1116 - 1123
ISSN: 1465-7392Online Volltext: dx.doi.org/ -
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaksIn: Nature Cell Biology Jg. 13 (2011) Nr. 11, S. 1376 - 1382
ISSN: 1465-7392Online Volltext: dx.doi.org/ -
A role for Cdc48/p97 and Aurora B in controlling chromatin condensation during exit from mitosisIn: Biochemistry and cell biology Jg. 88 (2010) Nr. 1, S. 23 - 28
ISSN: 0829-8211; 0714-7511; 0008-4018; 1208-6002Online Volltext: dx.doi.org/ -
Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradationIn: The Journal of Cell Biology Jg. 191 (2010) Nr. 3, S. 615 - 629
ISSN: 1540-8140; 0021-9525Online Volltext: dx.doi.org/ -
Role(s) of Cdc48/p97 in mitosisIn: Biochemical Society Transactions Jg. 36 (2008) Nr. 1, S. 126 - 130
ISSN: 0300-5127; 1470-8752 -
Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatinIn: Nature Jg. 450 (2007) Nr. 7173, S. 1258
ISSN: 0028-0836; 1476-4687 -
Detailed structural insights into the p97-Npl4-Ufd1 interfaceIn: Journal of Biological Chemistry Jg. 282 (2007) Nr. 29, S. 21361 - 21369
ISSN: 0021-9258; 1083-351X -
NSF- and SNARE-mediated membrane fusion is required for nuclear envelope formation and completion of nuclear pore complex assembly in Xenopus laevis egg extractsIn: Journal of Cell Science Jg. 120 (2007) Nr. 16, S. 2895 - 2903
ISSN: 0021-9533; 1477-9137; 0370-2952 -
Structural insights into the p97-Ufd1-NpI4 complexIn: Proceedings of the National Academy of Sciences of the United States of America Jg. 104 (2007) Nr. 2, S. 467 - 472
ISSN: 1091-6490; 0027-8424 -
Golgi reassembly after mitosis : The AAA family meets the ubiquitin familyIn: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Jg. 1744 (2005) Nr. 2, S. 108 - 119
ISSN: 1879-2596; 0167-4889Online Volltext: dx.doi.org/ (Open Access) -
The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanismIn: Journal of Biological Chemistry Jg. 279 (2004) Nr. 48, S. 49609 - 49616
ISSN: 0021-9258; 1083-351X -
Ubiquitin Interactions of NZF Zinc FingersIn: EMBO Journal Jg. 23 (2004) Nr. 7, S. 1411 - 1421
ISSN: 0261-4189 -
VCIP135 acts as a deubiquitinating enzyme during p97–p47-mediated reassembly of mitotic Golgi fragmentsIn: Journal of Cell Biology Jg. 164 (2004) Nr. 7, S. 973 - 978
ISSN: 0021-9525 -
Function of the p97–Ufd1–Npl4 complex in retrotranslocation from the ER to the cytosol : dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chainsIn: The Journal of Cell Biology Jg. 162 (2003) Nr. 1, S. 71 - 84
ISSN: 0021-9525Online Volltext: dx.doi.org/ -
Structure and Ubiquitin Interactions of the Conserved Zinc Finger Domain of Npl4In: Journal of Biological Chemistry Jg. 278 (2003) S. 20225 - 20234
ISSN: 0021-9258; 1083-351X -
The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosisIn: Cell Jg. 115 (2003) Nr. 3, S. 355 - 367
ISSN: 0092-8674 -
Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1–Npl4In: EMBO Journal Jg. 21 (2002) Nr. 21, S. 5645 - 5652.
ISSN: 0261-4189 -
Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assemblyIn: Nature Cell Biology Jg. 3 (2001) Nr. 12, S. 1086 - 1091
ISSN: 1465-7392 -
The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosolIn: Nature Jg. 414 (2001) S. 652 - 656
ISSN: 0028-0836; 1476-4687 -
A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathwaysIn: EMBO Journal Jg. 19 (2000) Nr. 10, S. 2181 - 2192
ISSN: 0261-4189 -
Structure of the AAA ATPase p97In: Molecular Cell Jg. 6 (2000) Nr. 6, S. 1473 - 1484
ISSN: 1097-2765 -
The mouse p97 (CDC48) gene. Genomic structure, definition of transcriptional regulatory sequences, gene expression, and characterization of a pseudogene.In: Journal of Biological Chemistry Jg. 274 (1999) Nr. 15, S. 10154 - 10162
ISSN: 0021-9258; 1083-351X -
The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97In: FEBS Letters Jg. 437 (1998) Nr. 3, S. 255 - 257
ISSN: 0014-5793; 1873-3468