Faculty of Biology

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Prof. Dr. Doris Hellerschmied-Jelinek

Biologie / Mechanistische Zellbiologie

Address
Universitätsstr 2
45117 Essen
Room
S05 T04 B30
Phone
+49 (0) 201 183 3120
E-Mail
doris.hellerschmied@uni-due.de
Website
https://www.uni-due.de/zmb/mechanistic-cell-biology/index.php

Functions

  • Professor/in, Mechanistische Zellbiologie

The following publications are listed in the online university bibliography of the University of Duisburg-Essen. Further information may also be found on the person's personal web pages.

    Journal articles

  • Sewald, Leonard; Molke, Niko; Tabak, Werner W. A.; Haak, Anette; Najdzion, Maja; Geiss-Friedlander, Ruth; Hellerschmied, Doris; Huber, Robert; Kaiser, Markus
    A Photocaged N-Phosphonopiperidinone as a Selective Photo-Cleavable DPP8/9 Inhibitor
    In: ChemBioChem, Vol. 26, 2025, Nr. 19, e202500558
    DOI (Open Access)
  • Brenner, Joel Cyrille; Zirden, Linda; Almeida-Hernandez, Yasser; Kaschani, Farnusch; Kaiser, Markus; Sanchez-Garcia, Elsa; Poepsel, Simon; Hellerschmied-Jelinek, Doris
    Conformational plasticity of a BiP-GRP94 chaperone complex
    In: Nature Structural & Molecular Biology, Vol. 32, 2025, Nr. 10, pp. 1947 – 1958
    DOI (Open Access)
  • Hagemeier, Birte; Ripkens, Kamilla; Schulze, Nina; Bluemke, Anika; Strzala, Michal; Koci, Michelle; Kaschani, Farnusch; Kaiser, Markus; Erkelenz, Michael; Schluecker, Sebastian; Merdanovic, Melisa; Poepsel, Simon; Hellerschmied, Doris; Burston, Steven G.; Ehrmann, Michael
    The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations
    In: The Journal of Biological Chemistry (JBC), Vol. 301, 2025, Nr. 10, 110729
    DOI, Online Full Text (Open Access)
  • Schillinger, Jasmin; Koci, Michelle; Bravo-Rodriguez, Kenny; Heilmann, Geronimo; Kaschani, Farnusch; Kaiser, Markus; Beuck, Christine; Luecke, Hartmut; Huber, Robert; Hellerschmied-Jelinek, Doris; Burston, Steven G.; Ehrmann, Michael
    High resolution analysis of proteolytic substrate processing
    In: The Journal of Biological Chemistry (JBC), Vol. 300, 2024, Nr. 11, 107812
    DOI, Online Full Text (Open Access)
  • Pol, Savina Abraham; Liljenberg, Sara; Barr, Jack; Simon, Gina; Wong-Dilworth, Luis; Paterson, Danielle L.; Berishvili, Vladimir P.; Bottanelli, Francesca; Kaschani, Farnusch; Kaiser, Markus; Pettersson, Mariell; Hellerschmied, Doris
    Induced degradation of SNAP-fusion proteins
    In: RSC Chemical Biology, Vol. 5, 2024, Nr. 12, pp. 1232 – 1247
    DOI (Open Access)
  • Buzuk, Lana; Hellerschmied-Jelinek, Doris
    Ubiquitin-mediated degradation at the Golgi apparatus
    In: Frontiers in Molecular Biosciences, Vol. 10, 2023, 1197921
    DOI, Online Full Text (Open Access)
  • Schillinger, Jasmin; Hellerschmied, Doris
    Zellen unter Stress : Entspannung mit Hilfe von Proteinen
    In: Unikate: Berichte aus Forschung und Lehre, 2021, Nr. 56, Heft "Junge Wilde" - Die nächste Generation
    DOI, Online Full Text (Open Access)
  • Hellerschmied, Doris; Lehner, Anita; Franicevic, Nina; Arnese, Renato; Johnson, Chloe; Vogel, Antonia; Meinhart, Anton; Kurzbauer, Robert; Deszcz, Luiza; Gazda, Linn; Geeves, Michael; Clausen, Tim
    Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin
    In: Nature Communications, Vol. 10, 2019, Nr. 1, 4781
    DOI (Open Access)
  • Hellerschmied, Doris; Serebrenik, Yevgeniy V.; Shao, Lin; Burslem, George M.; Crews, Craig M.
    Protein folding state-dependent sorting at the Golgi apparatus
    In: Molecular Biology of the Cell, Vol. 30, 2019, Nr. 17, pp. 2296 – 2308
    DOI (Open Access)
  • Serebrenik, Yevgeniy V.; Hellerschmied, Doris; Toure, Momar; López-Giráldez, Francesc; Brookner, Dennis; Crews, Craig M.
    Targeted protein unfolding uncovers a Golgi-specific transcriptional stress response
    In: Molecular Biology of the Cell, Vol. 29, 2018, Nr. 11, pp. 1284 – 1298
    DOI (Open Access)
  • Hellerschmied, Doris; Roessler, Max; Lehner, Anita; Gazda, Linn; Stejskal, Karel; Imre, Richard; Mechtler, Karl; Dammermann, Alexander; Clausen, Tim
    UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins
    In: Nature Communications, Vol. 9, 2018, Nr. 1, 484
    DOI (Open Access)
  • Lai, Ashton C.; Toure, Momar; Hellerschmied, Doris; Salami, Jemilat; Jaime-Figueroa, Saul; Ko, Eunhwa; Hines, John; Crews, Craig M.
    Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL
    In: Angewandte Chemie International Edition, Vol. 55, 2016, Nr. 2, pp. 807 – 810
    DOI
  • Schneider, Maren; Hellerschmied, Doris; Schubert, Tobias; Amlacher, Stefan; Vinayachandran, Vinesh; Reja, Rohit; Pugh, B. Franklin; Clausen, Tim; Köhler, Alwin
    The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression
    In: Cell, Vol. 162, 2015, Nr. 5, pp. 1016 – 1028
    DOI (Open Access)
  • Hellerschmied, Doris; Clausen, Tim
    Myosin chaperones
    In: Current Opinion in Structural Biology, Vol. 25, 2014, pp. 9 – 15
    DOI (Open Access)
  • Gazda, Linn; Pokrzywa, Wojciech; Hellerschmied, Doris; Löwe, Thomas; Forné, Ignasi; Mueller-Planitz, Felix; Hoppe, Thorsten; Clausen, Tim
    The Myosin Chaperone UNC-45 Is Organized in Tandem Modules to Support Myofilament Formation in C. elegans
    In: Cell, Vol. 152, 2013, Nr. 1-2, pp. 183 – 195
    DOI (Open Access)

    • Preprints

  • Blümke, Anika; Hagemeier, Birte; Ripkens, Kamilla; Schulze, Nina; Strzala, Michal; Koci, Michelle; Kaschani, Farnusch; Kaiser, Markus; Erkelenz, Michael; Schlücker, Sebastian; Merdanovic, Melisa; Poepsel, Simon; Hellerschmied-Jelinek, Doris; Burston, Steve; Ehrmann, Michael
    A non-autonomous protein quality control mechanism targeting tau aggregate propagation
    2024
    DOI (Open Access)

    • Book articles / Proceedings papers

  • Diamantino, Joao; Hellerschmied-Jelinek, Doris
    Cellular Principles of Targeted Protein Degradation
    In: Inducing Targeted Protein Degradation: from Chemical Biology to Drug Discovery and Clinical Applications / Cromm, Philipp (Eds.). Weinheim: Wiley, 2022, pp. 25 – 62
    DOI
  • Schillinger, Jasmin; Hellerschmied-Jelinek, Doris
    Targeted Protein Unfolding at the Golgi Apparatus
    In: Golgi: Methods and Protocols / Wang, Yanzhuang; Lupashin, Vladimir V.; Graham, Todd R. (Eds.). New York: Humana Press, 2022, pp. 645 – 659
    DOI