Publications
Selected Publications
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Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochoreIn: The EMBO Journal Vol. 40 (2021) Nr. 18,ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/ (Open Access)
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Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeastIn: The EMBO Journal Vol. 39 (2020) Nr. 14, pp. e102938ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Molecular basis for inner kinetochore configuration through RWD domain–peptide interactionsIn: The EMBO Journal Vol. 36 (2017) Nr. 23, pp. 3458 - 3482ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/ (Open Access)
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A Force-Induced Directional Switch of a Molecular Motor Enables Parallel Microtubule Bundle FormationIn: Cell Vol. 167 (2016) Nr. 2, pp. 539 - 552.e14ISSN: 0092-8674; 1097-4172Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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BiGBac enables rapid gene assembly for the expression of large multisubunit protein complexesIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 113 (2016) Nr. 19, pp. E2564 - E2569ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/ (Open Access)
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CCAN Assembly Configures Composite Binding Interfaces to Promote Cross-Linking of Ndc80 Complexes at the KinetochoreIn: Current Biology Vol. 26 (2016) Nr. 17, pp. 2370 - 2378ISSN: 1879-0445; 0960-9822Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptorsIn: The EMBO Journal Vol. 32 (2013) Nr. 3, pp. 409 - 423ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/
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CENP-T proteins are conserved centromere receptors of the Ndc80 complexIn: Nature Cell Biology Vol. 14 (2012) Nr. 6, pp. 604 - 613ISSN: 1476-4679; 1097-6256Online Full Text: dx.doi.org/
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Spatiotemporal regulation of Ipl1/Aurora activity by direct Cdk1 phosphorylationIn: Current Biology Vol. 22 (2012) Nr. 9, pp. 787 - 793ISSN: 1879-0445; 0960-9822Online Full Text: dx.doi.org/
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A blueprint for kinetochores - new insights into the molecular mechanics of cell divisionIn: Nature reviews. Molecular cell biology Vol. 12 (2011) Nr. 7, pp. 407 - 412ISSN: 1471-0080Online Full Text: dx.doi.org/
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A Dam1-based artificial kinetochore is sufficient to promote chromosome segregation in budding yeastIn: Nature Cell Biology Vol. 11 (2009) Nr. 9, pp. 1109 - 1115ISSN: 1476-4679; 1097-6256Online Full Text: dx.doi.org/
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Different assemblies of the DAM1 complex follow shortening microtubules by distinct mechanismsIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 105 (2008) Nr. 19, pp. 6918 - 6923ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/
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The Dam1 ring binds microtubules strongly enough to be a processive as well as energy-efficient coupler for chromosome motionIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 105 (2008) Nr. 40, pp. 15423 - 15428ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/
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Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanismsIn: Nature Structural & Molecular Biology Vol. 14 (2007) Nr. 8, pp. 721 - 726ISSN: 1545-9993; 1545-9985; 1072-8368Online Full Text: dx.doi.org/
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Structures and functions of yeast kinetochore complexesIn: Annual Review of Biochemistry Vol. 76 (2007) pp. 563 - 591ISSN: 1545-4509Online Full Text: dx.doi.org/
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The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule endsIn: Nature Vol. 440 (2006) Nr. 7083, pp. 565 - 569ISSN: 0028-0836; 1476-4687Online Full Text: dx.doi.org/
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Formation of a dynamic kinetochore-microtubule interface through assembly of the Dam1 ring complexIn: Molecular Cell Vol. 17 (2005) Nr. 2, pp. 277 - 290ISSN: 1097-2765; 1097-4164Online Full Text: dx.doi.org/
Journal articles
All Publications
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Multivalent Molecular Tweezers Disrupt the Essential NDC80 Interaction with MicrotubulesIn: Journal of the American Chemical Society: JACS Vol. 145 (2023) Nr. 28, pp. 15251 - 15264ISSN: 0002-7863; 1520-5126Online Full Text: dx.doi.org/
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Systematic analysis of microtubule plus-end networks defines EB-cargo complexes critical for mitosis in budding yeastIn: Molecular Biology of the Cell Vol. 34 (2023) Nr. 5,ISSN: 1059-1524; 1939-4586; 1044-2030Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Cdc4 phospho-degrons allow differential regulation of ame1ceⁿp⁻u protein stability across the cell cycleIn: eLife Vol. 10 (2021)ISSN: 2050-084XOnline Full Text: dx.doi.org/ (Open Access)
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Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochoreIn: The EMBO Journal Vol. 40 (2021) Nr. 18,ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/ (Open Access)
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Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeastIn: The EMBO Journal Vol. 39 (2020) Nr. 14, pp. e102938ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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The EB1-Kinesin-14 complex is required for efficient metaphase spindle assembly and kinetochore bi-orientationIn: The Journal of Cell Biology (JCB) Vol. 219 (2020) Nr. 12,ISSN: 1540-8140; 0021-9525Online Full Text: dx.doi.org/ (Open Access)
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Molecular basis for inner kinetochore configuration through RWD domain–peptide interactionsIn: The EMBO Journal Vol. 36 (2017) Nr. 23, pp. 3458 - 3482ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/ (Open Access)
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Structural differences between yeast and mammalian microtubules revealed by cryo-EMIn: The Journal of Cell Biology (JCB) Vol. 216 (2017) Nr. 9, pp. 2669 - 2677ISSN: 1540-8140; 0021-9525Online Full Text: dx.doi.org/ (Open Access)
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TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2In: The Journal of Cell Biology (JCB) Vol. 216 (2017) Nr. 11, pp. 3471 - 3484ISSN: 1540-8140; 0021-9525Online Full Text: dx.doi.org/ (Open Access)
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A Force-Induced Directional Switch of a Molecular Motor Enables Parallel Microtubule Bundle FormationIn: Cell Vol. 167 (2016) Nr. 2, pp. 539 - 552.e14ISSN: 0092-8674; 1097-4172Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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BiGBac enables rapid gene assembly for the expression of large multisubunit protein complexesIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 113 (2016) Nr. 19, pp. E2564 - E2569ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/ (Open Access)
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CCAN Assembly Configures Composite Binding Interfaces to Promote Cross-Linking of Ndc80 Complexes at the KinetochoreIn: Current Biology Vol. 26 (2016) Nr. 17, pp. 2370 - 2378ISSN: 1879-0445; 0960-9822Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Non-catalytic motor domains enable processive movement and functional diversification of the kinesin-14 Kar3In: eLife Vol. 4 (2015) pp. e04489ISSN: 2050-084XOnline Full Text: dx.doi.org/ (Open Access)
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A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-AIn: The Journal of Cell Biology (JCB) Vol. 206 (2014) Nr. 4, pp. 506 - 524ISSN: 1540-8140; 0021-9525Online Full Text: dx.doi.org/ (Open Access)
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“Uno, nessuno e centomila” : the different faces of the budding yeast kinetochoreIn: Chromosoma Vol. 123 (2014) Nr. 5, pp. 447 - 457ISSN: 1432-0886; 0009-5915Online Full Text: dx.doi.org/
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A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptorsIn: The EMBO Journal Vol. 32 (2013) Nr. 3, pp. 409 - 423ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/
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Esperanto for histones : CENP-A, not CenH3, is the centromeric histone H3 variantIn: Chromosome Research Vol. 21 (2013) Nr. 2, pp. 101 - 106ISSN: 1573-6849; 0967-3849Online Full Text: dx.doi.org/
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Molecular requirements for the formation of a kinetochore–microtubule interface by Dam1 and Ndc80 complexesIn: The Journal of Cell Biology (JCB) Vol. 200 (2013) Nr. 1, pp. 21 - 30ISSN: 1540-8140; 0021-9525Online Full Text: dx.doi.org/
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CENP-T proteins are conserved centromere receptors of the Ndc80 complexIn: Nature Cell Biology Vol. 14 (2012) Nr. 6, pp. 604 - 613ISSN: 1476-4679; 1097-6256Online Full Text: dx.doi.org/
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Family matters: structural and functional conservation of centromere-associated proteins from yeast to humansIn: Trends in Cell Biology Vol. 23 (2012) Nr. 6, pp. 260 - 269ISSN: 1879-3088; 0962-8924Online Full Text: dx.doi.org/
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Spatiotemporal regulation of Ipl1/Aurora activity by direct Cdk1 phosphorylationIn: Current Biology Vol. 22 (2012) Nr. 9, pp. 787 - 793ISSN: 1879-0445; 0960-9822Online Full Text: dx.doi.org/
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A blueprint for kinetochores - new insights into the molecular mechanics of cell divisionIn: Nature reviews. Molecular cell biology Vol. 12 (2011) Nr. 7, pp. 407 - 412ISSN: 1471-0080Online Full Text: dx.doi.org/
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Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complexIn: Journal of Molecular Biology (JMB) Vol. 405 (2011) Nr. 2, pp. 548 - 559ISSN: 1089-8638; 0022-2836Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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The Dam1 complex confers microtubule plus end–tracking activity to the Ndc80 kinetochore complexIn: The Journal of Cell Biology (JCB) Vol. 189 (2010) Nr. 4, pp. 641 - 649ISSN: 1540-8140; 0021-9525Online Full Text: dx.doi.org/
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A Dam1-based artificial kinetochore is sufficient to promote chromosome segregation in budding yeastIn: Nature Cell Biology Vol. 11 (2009) Nr. 9, pp. 1109 - 1115ISSN: 1476-4679; 1097-6256Online Full Text: dx.doi.org/
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Phosphoregulation of the budding yeast EB1 homologue Bim1p by Aurora/Ipl1pIn: The Journal of Cell Biology (JCB) Vol. 186 (2009) Nr. 3, pp. 379 - 391ISSN: 1540-8140; 0021-9525Online Full Text: dx.doi.org/
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Architecture and flexibility of the yeast Ndc80 kinetochore complexIn: Journal of Molecular Biology (JMB) Vol. 383 (2008) Nr. 4, pp. 894 - 903ISSN: 1089-8638; 0022-2836Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Different assemblies of the DAM1 complex follow shortening microtubules by distinct mechanismsIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 105 (2008) Nr. 19, pp. 6918 - 6923ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/
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The Dam1 ring binds microtubules strongly enough to be a processive as well as energy-efficient coupler for chromosome motionIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 105 (2008) Nr. 40, pp. 15423 - 15428ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/
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A protein interaction map of the mitotic spindleIn: Molecular Biology of the Cell (MBoC) Vol. 18 (2007) Nr. 10, pp. 3800 - 3809ISSN: 1939-4586Online Full Text: dx.doi.org/
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Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanismsIn: Nature Structural & Molecular Biology Vol. 14 (2007) Nr. 8, pp. 721 - 726ISSN: 1545-9993; 1545-9985; 1072-8368Online Full Text: dx.doi.org/
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Structures and functions of yeast kinetochore complexesIn: Annual Review of Biochemistry Vol. 76 (2007) pp. 563 - 591ISSN: 1545-4509Online Full Text: dx.doi.org/
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The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule endsIn: Nature Vol. 440 (2006) Nr. 7083, pp. 565 - 569ISSN: 0028-0836; 1476-4687Online Full Text: dx.doi.org/
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Formation of a dynamic kinetochore-microtubule interface through assembly of the Dam1 ring complexIn: Molecular Cell Vol. 17 (2005) Nr. 2, pp. 277 - 290ISSN: 1097-2765; 1097-4164Online Full Text: dx.doi.org/
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Architecture of the budding yeast kinetochore reveals a conserved molecular coreIn: The Journal of Cell Biology (JCB) Vol. 163 (2003) Nr. 2, pp. 215 - 222ISSN: 1540-8140; 0021-9525Online Full Text: dx.doi.org/