Our 4D approach combines multidimensional chromatography with ion mobility–mass spectrometry (IM–MS), enabling the separation of >1,000 components per hour based on functional groups, size, and mass—allowing analysis of tens of thousands of analytes in a single sample.

Single-cell Metabolomics for Cancer Research

To tackle the data complexity, we use software-assisted workflows (Python/R), particularly in metabolomic and lipidomic cancer research. Together with national and international partners, we study tumor cell metastasis and chemotherapy resistance, supported by a single-cell ion source for metabolomic analysis at the cellular level.

IM–MS Solutions to Distinguish Isomers

A key challenge is distinguishing structural isomers (e.g., glucose vs. fructose). Since chromatographic preseparation isn’t feasible in single-cell experiments, we advance IM–MS coupling: IMS separates ions by size-to-charge ratio, while MS separates by mass-to-charge ratio, overcoming limitations for isobaric compounds.

Universal Ion Sources for all Analyte Types

Additionally, we develop novel ion sources to efficiently ionize diverse analytes—regardless of polarity, size, or thermal stability—aiming for a universal "all-rounder" solution.

Sustainable Chemistry

Our work also addresses future challenges, such as CO₂-to-kerosene conversion (with industry partners) and recycled feedstocks, providing analytical foundations for sustainable chemistry.