29.07.2025 - 21:56:01

ATXN3 Identified as Key Regulator of Lysosome Regeneration

ATXN3 Identified as Key Regulator of Lysosome Regeneration: The Meyer lab (A03) has collaborated with the Kaiser lab (B01) and the ICCE (Z02) on their latest paper "ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains". Published in The EMBO Journal, the findings reveal that the enzyme ATXN3 plays a crucial role in lysosome regeneration after damage. Researchers used CRISPR/Cas9-mediated gene knockout and live-cell imaging to show that ATXN3 is recruited after initial membrane repair to remove K48-K63–branched ubiquitin chains, a key step for restoring lysosomal function. Loss of ATXN3 disrupts lysophagy and lysosomal recovery, highlighting its importance in cellular homeostasis.