B01 investigates how the dynamically evolving tumor microenvironment in melanoma shapes diverse cancer-associated fibroblast states that drive immune responsiveness and immediate resistance to immune checkpoint blockade within the DYNAMO Window. Using spatial multi-omics of longitudinal patient samples, B01 defines how stromal adaptation fuels early resistance, providing key insight into multicellular therapy adaptation.

Project Leaders

Becker, Jürgen C., MD, PhD

• https://dktk.dkfz.de/forschung/dktk-wissenschaftler/jurgen-becker

Cheung, Phyllis Fung-Yi, PhD

• https://dktk.dkfz.de/en/research/dktk-researchers/cheung-group