B04 investigates how melanoma cell states and oncogenic signaling shape NK-cell recruitment and functional plasticity within the DYNAMO Window, the early treatment phase during which innate immunity critically influences therapeutic outcome. Using spatial and single-cell profiling, lineage tracing, and preclinical models, it defines how tumor-intrinsic programs rewire NK-cell effector states and feedback circuits, advancing DYNAMO’s goal to integrate immediate tumor–immune dynamics driving resistance.

Project Leaders

Grüner, Barbara M., Prof. Dr. rer. nat.

• https://tumorforschung.uk-essen.de/forschung/zellplastizitaet-metastasierung/

Bald, Tobias, Prof. Dr. rer. nat.

• https://ieo.uni-bonn.de/