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Funktionen

  • Wissenschaftliche/r Mitarbeiter/in, Institut für Zellbiologie (Tumorforschung)

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Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Trommer, Maike; Grohmann, Maximilian; Fabian, Alexander; Ehret, Felix; Hess, Julia; Rückert, Michael; Matschke, Johann; Stefanowicz, Sarah; Rühle, Alexander; Ferdinandus, Simone; Merten, Ricarda; Besserer, Angela; Schmidt, Livia; Sperk, Elena; Depardon, Alina; Putz, Florian; Petersen, Cordula; Haderlein, Marlen; Schröder, Annemarie; Weissmann, Thomas; Deloch, Lisa
    Balancing barriers: Family, career, and gender equality in radiation oncology and radiation research : An interdisciplinary prospective survey among the young workforce
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics, 2025, in press
  • Schubert, Annika; Lobo Barbosa da Silva, Maria Eduarda; Ambrock, Tabea; Terosian, Orbel; Malyshkina, Anna; Padberg, Claudia; Larafa, Safa; Matschke, Johann; Fandrey, Joachim; Henning, Yoshiyuki
    Targeting hypoxia-inducible factor-1 in a hypoxidative stress model protects retinal pigment epithelium cells from cell death and metabolic dysregulation
    In: Cell Death Discovery, Jg. 11, 2025, Nr. 1, 380
  • Cihankaya, Hilal; Bader, Verian; Winklhofer, Konstanze F.; Vorgerd, Matthias; Matschke, Johann; Stahlke, Sarah; Theiss, Carsten; Matschke, Veronika
    Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS
    In: Cells, Jg. 13, 2024, Nr. 12, 995
  • Weissmann, Thomas; Deloch, Lisa; Grohmann, Maximilian; Trommer, Maike; Fabian, Alexander; Ehret, Felix; Stefanowicz, Sarah; Rühle, Alexander; Lettmaier, Sebastian; Putz, Florian; Shariff, Maya; Wegen, Simone; Matschke, Johann; Sperk, Elena; Schröder, Annemarie
    German radiation oncology’s next generation : A web-based survey of young biologists, medical physicists, and physicians — from problems to solutions
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics, Jg. 200, 2024, Nr. 12, S. 1005 – 1024
  • Dankó, Benedek; Hess, Julia; Unger, Kristian; Samaga, Daniel; Walz, Christoph; Walch, Axel; Sun, Na; Baumeister, Philipp; Zeng, Peter Y. F.; Walter, Franziska; Marschner, Sebastian; Späth, Richard; Gires, Olivier; Herkommer, Timm; Dazeh, Ramin; Matos, Thaina; Kreutzer, Lisa; Matschke, Johann; Eul, Katharina; Klauschen, Frederick; Pflugradt, Ulrike; Canis, Martin; Ganswindt, Ute; Mymryk, Joe S.; Wollenberg, Barbara; Nichols, Anthony C.; Belka, Claus; Zitzelsberger, Horst; Lauber, Kirsten; Selmansberger, Martin
    Metabolic pathway-based subtypes associate glycan biosynthesis and treatment response in head and neck cancer
    In: npj Precision Oncology, Jg. 8, 2024, Nr. 1, 116
  • Xiang, Kexu; Kunin, Mikhail; Larafa, Safa; Busch, Maike; Dünker, Nicole; Jendrossek, Verena; Matschke, Johann
    α-Ketoglutarate supplementation and NAD+ modulation enhance metabolic rewiring and radiosensitization in SLC25A1 inhibited cancer cells
    In: Cell Death Discovery, Jg. 10, 2024, Nr. 1, 27
  • Kebir, Sied; Ullrich, Vivien; Berger, Pia; Dobersalske, Celia; Langer, Sarah; Rauschenbach, Laurèl; Trageser, Daniel; Till, Andreas; Lorbeer, Franziska K.; Wieland, Anja; Wilhelm-Buchstab, Timo; Ahmad, Ashar; Fröhlich, Holger; Cima, Igor; Prasad, Shruthi; Matschke, Johann; Jendrossek, Verena; Remke, Marc; Grüner, Barbara M.; Rösch, Alexander; Siveke, Jens T.; Herold-Mende, Christel; Blau, Tobias; Keyvani, Kathy; van Landeghem, Frank K H; Pietsch, Torsten; Felsberg, Jörg; Reifenberger, Guido; Weller, Michael; Sure, Ulrich; Brüstle, Oliver; Simon, Matthias; Glas, Martin; Scheffler, Björn
    A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
    In: Clinical Cancer Research, Jg. 29, 2023, Nr. 2, S. 488 – 500
  • Henning, Yoshiyuki; Willbrand, Katrin; Larafa, Safa; Weißenberg, Gesa; Matschke, Veronika; Theiss, Carsten; Görtz, Gina-Eva; Matschke, Johann
    Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1α under normoxia
    In: Cell Death Discovery, Jg. 9, 2023, Nr. 1, 398
  • Dellin, Maurice; Rohrbeck, Ina; Asrani, Purva; Schreiber, Julian A.; Ritter, Nadine; Glorius, Frank; Wünsch, Bernhard; Budde, Thomas; Temme, Louisa; Strünker, Timo; Stallmeyer, Birgit; Tüttelmann, Frank; Meuth, Sven G.; Spehr, Marc; Matschke, Johann; Steinbicker, Andrea; Gatsogiannis, Christos; Stoll, Raphael; Strutz-Seebohm, Nathalie; Seebohm, Guiscard
    The second PI(3,5)P₂binding site in the S0 helix of KCNQ1 stabilizes PIP₂-at the primary PI1 site with potential consequences on intermediate-to-open state transition
    In: Biological Chemistry, Jg. 404, 2023, Nr. 4, S. 241 – 254
  • Xiang, Kexu; Kalthoff, Christian; Münch, Corinna; Jendrossek, Verena; Matschke, Johann
    Accumulation of oncometabolite D-2-Hydroxyglutarate by SLC25A1 inhibition: A metabolic strategy for induction of HR-ness and radiosensitivity
    In: Cell Death and Disease, Jg. 13, 2022, Nr. 7, 641
  • Henning, Yoshiyuki; Blind, Ursula Sarah; Larafa, Safa; Matschke, Johann; Fandrey, Joachim
    Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction
    In: Cell Death and Disease, Jg. 13, 2022, Nr. 7, 662
  • Junghans, Maya; John, Felix; Cihankaya, Hilal; Schliebs, Daniel; Winklhofer, Konstanze F.; Bader, Verian; Matschke, Johann; Theiss, Carsten; Matschke, Veronika
    ROS scavengers decrease γH2ax spots in motor neuronal nuclei of ALS model mice in vitro
    In: Frontiers in Cellular Neuroscience, Jg. 16, 2022, 963169
  • Goetting, Isabell; Larafa, Safa; Eul, Katharina; Kunin, Mikhail; Jakob, Burkhard; Matschke, Johann; Jendrossek, Verena
    Targeting AKT-Dependent Regulation of Antioxidant Defense Sensitizes AKT-E17K Expressing Cancer Cells to Ionizing Radiation
    In: Frontiers in Oncology, Jg. 12, 2022, 920017
  • Hansel, Christine; Hlouschek, Julian; Xiang, Kexu; Melnikova, Margarita; Thomale, Jürgen; Helleday, Thomas; Jendrossek, Verena; Matschke, Johann
    Adaptation to chronic-cycling hypoxia renders cancer cells resistant to mth1-inhibitor treatment which can be counteracted by glutathione depletion
    In: Cells, Jg. 10, 2021, Nr. 11, 3040
  • Stein, Jan; Walkenfort, Bernd; Cihankaya, Hilal; Hasenberg, Mike; Bader, Verian; Winklhofer, Konstanze F.; Röderer, Pascal; Matschke, Johann; Theiss, Carsten; Matschke, Veronika
    Increased ROS-Dependent Fission of Mitochondria Causes Abnormal Morphology of the Cell Powerhouses in a Murine Model of Amyotrophic Lateral Sclerosis
    In: Oxidative Medicine and Cellular Longevity, Jg. 2021, 2021, 6924251
  • Matschke, Johann; Larafa, Safa; Jendrossek, Verena
    Metabolic reprograming of antioxidant defense : A precision medicine perspective for radiotherapy of lung cancer?
    In: Biochemical Society Transactions, Jg. 49, 2021, Nr. 3, S. 1265 – 1277
  • Krysztofiak, Adam; Szymonowicz, Klaudia; Hlouschek, Julian; Xiang, Kexu; Waterkamp, Christoph; Larafa, Safa; Goetting, Isabell; Vega-Rubin-de-Celis, Silvia; Theiss, Carsten; Matschke, Veronika; Hoffmann, Daniel; Jendrossek, Verena; Matschke, Johann
    Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown
    In: iScience, Jg. 24, 2021, Nr. 11, 103366
  • Götting, Isabell; Jendrossek, Verena; Matschke, Johann
    A new twist in protein kinase b/akt signaling : Role of altered cancer cell metabolism in akt-mediated therapy resistance
    In: International Journal of Molecular Sciences (IJMS), Jg. 21, 2020, Nr. 22, S. 8563
  • Xiang, Kexu; Jendrossek, Verena; Matschke, Johann
    Oncometabolites and the response to radiotherapy
    In: Radiation Oncology, Jg. 15, 2020, S. 197
  • Szymonowicz, Klaudia; Krysztofiak, Adam; van der Linden, Jansje; Kern, Ajvar; Deycmar, Simon; Oeck, Sebastian; Squire, Anthony; Koska, Benjamin; Hlouschek, Julian; Vüllings, Melanie; Neander, Christian; Siveke, Jens T.; Matschke, Johann; Pruschy, Martin; Timmermann, Beate; Jendrossek, Verena
    Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining
    In: Cells, Jg. 9, 2020, Nr. 4, 889
  • Matschke, Veronika; Theiss, Carsten; Matschke, Johann
    Oxidative stress: the lowest common denominator of multiple diseases
    In: Neural Regeneration Research, Jg. 14, 2019, Nr. 2, S. 238 – 241
  • Shannan, B.; Matschke, Johann; Chauvistré, Heike; Vogel, F.; Klein, Diana; Meier, Friedegund; Westphal, Dana; Bruns, Johannes; Rauschenberg, Ricarda; Utikal, Jochen; Forschner, Andrea; Berking, Carola; Terheyden, Patrick; Dabrowski, Evelyn; Gutzmer, Ralf; Rafei-Shamsabadi, David Ali; Meiss, Frank; Heinzerling, Lucie M.; Zimmer, Lisa; Livingstone, Elisabeth; Váraljai, Renáta; Hoewner, A.; Horn, Susanne; Klode, Joachim; Stuschke, Martin; Scheffler, Björn; Marchetto, Aruna; Sannino, Giuseppina; Grünewald, Thomas Georg Philipp; Schadendorf, Dirk; Jendrossek, Verena; Rösch, Alexander
    Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV⁶⁰⁰E inhibition in melanoma
    In: European Journal of Cancer (EJC), Jg. 109, 2019, S. 137 – 153
  • Hlouschek, Julian; Ritter, Violetta; Wirsdörfer, Florian; Klein, Diana; Jendrossek, Verena; Matschke, Johann
    Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia
    In: Cancer Letters, Jg. 439, 2018, S. 24 – 38
  • Hlouschek, Julian; Hansel, Christine; Jendrossek, Verena; Matschke, Johann
    The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia
    In: Frontiers in Oncology, Jg. 8, 2018, S. 170
  • Matschke, Johann; Wiebeck, Elisa; Hurst, Sebastian; Rudner, Justine; Jendrossek, Verena
    Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia
    In: Radiation Oncology, Jg. 11, 2016, Nr. 1, S. 75 – 87
  • Matschke, Johann; Riffkin, Helena; Klein, Diana; Handrick, René; Lüdemann, Lutz; Metzen, Eric; Shlomi, Tomer; Stuschke, Martin; Jendrossek, Verena
    Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia
    In: Antioxidants and Redox Signaling, Jg. 25, 2016, Nr. 2, S. 89 – 107
  • Matschke, Veronika; Piccini, Ilaria; Schubert, Janina; Wrobel, Eva; Lang, Florian; Matschke, Johann; Amedonu, Elsie; Meuth, Sven G; Strünker, Timo; Strutz-Seebohm, Nathalie; Greber, Boris; Scherkenbeck, Jürgen; Seebohm, Guiscard
    The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels
    In: Cellular Physiology and Biochemistry, Jg. 40, 2016, Nr. 6, S. 1549 – 1558
  • Matschke, Johann; Riffkin, H.; Handrick, R.; Klein-Hitpaß, Ludger; Jendrossek, Verena
    Chronic intermittent hypoxia triggers adaptive changes that promote protection against cell death
    In: European Journal of Cancer (EJC), Jg. 49, 2013, Nr. Suppl. 2, S. 101
  • Abstracts

  • Schubert, Annika; Lobo Barbosa da Silva, Maria E.; Ambrock, Tabea; Terosian, Orbel; Malyshkina, Anna; Padberg, Claudia; Larafa, Safa; Matschke, Johann; Fandrey, Joachim; Henning, Yoshiyuki
    Targeting hypoxia-inducible factor-1 in a hypoxidative stress model protects retinal pigment epithelium cells from cell death and metabolic dysregulation
    Europhysiology 2025, 40th Congress of the International Union of Physiological Sciences, 11–14 September 2025, Frankfurt, Germany,
    In: Acta Physiologica. Weinheim: Wiley-Blackwell, Jg. 241, 2025, Nr. S735, S. 118
  • Hessenow, Razan; Behrends, Carina; Xixi, Lin; Mladenov, Emil; Matschke, Johann; Aashish, Soni; Stuschke, Martin; Iliakis, George; Jendrossek, Verena; Timmermann, Beate
    Defects in DNA Damage Response Reinforce Proton Beam Specific Radiosensitivity of Cancer Cells
    29. Kongress der Deutschen Gesellschaft für Radioonkologie (DEGRO), 22. bis 24. Juni 2023, Kassel, Germany,
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 199, 2023, Nr. Suppl. 1, S. S36 – S37
  • Matschke, Johann
    Cross-talk of radiotherapy-induced mitochondrial impairment and resulting metabolic reprogramming impact DNA DSB repair capacity
    ESTRO 2022: Learning from every patient, 6-10 May 2022, Copenhagen,
    In: Radiotherapy and Oncology (The Green Journal). Amsterdam: Elsevier, Jg. 170, 2022, Nr. Supplement 1: ESTRO 2022, 6-10 May 2022, Copenhagen. Onsite in Copenhagen and Online, S. S307
  • Shannan, B.; Matschke, Johann; Larafa, S.; Schadendorf, Dirk; Jendrossek, Verena; Rösch, Alexander
    KDM5B's role in creating radiation synthetic vulnerabilities and its effects on sequential therapy combinations
    48th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF): Virtual, Innsbruck, 23-26 February 2022,
    In: Experimental Dermatology. Hoboken: Wiley, Jg. 31, 2022, Nr. 2, S. e9 – e10
  • Krysztofiak, A.; Szymonomicz, K.; Hlouschek, J.; Xiang, K.; Waterkamp, C.; Larafa, S.; Goetting, I.; Vega-Rubin-de-Celis, S.; Theiss, C.; Matschke, V.; Hoffmann, Daniel; Jendrossek, Verena; Matschke, Johann
    Ensuring fuels for DNA repair : Analysis of irradiated cancer cells reveals mitochondrial shutdown
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 197, 2021, Nr. Suppl. 1, S. 200
  • Krysztofiak, Adam; Szymonowicz, Klaudia A.; Hlouschek, Julian; Waterkamp, Christoph; Xiang, Kexu; Hoffmann, Daniel; Jendrossek, Verena; Matschke, Johann
    Modeling common aspects of the metabolic response of cancer cells to ionizing radiation
    AACR Annual Meeting 2021, April 10-15, 2021 and May 17-21, 2021, Philadelphia, PA, USA,
    In: Cancer Research. Philadelphia: American Association for Cancer Research (AACR), Jg. 81, 2021, Nr. Suppl. 13, 3065
  • Shannan, B.; Matschke, Johann; Jendrossek, Verena; Rösch, Alexander
    The Role of KDM5B in the Development of radiation-synthetic Vulnerability and its Effect on sequential Therapy Combinations
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG). Hoboken: Wiley-Blackwell - STM, Jg. 19, 2021, Nr. Suppl. 4, S. 74
  • Xiang, K.; Kalthoff, C.; Münch, C.; Hlouschek, J.; Jendrossek, Verena; Matschke, Johann
    The citrate carrier SLC25A1 acts as master regulator of metabolic reprogramming and offers an innovative strategy for metabolic induction of HRness and synthetic lethality approaches with radiotherapy
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 197, 2021, Nr. Suppl. 1, S. 48 – S49
  • Kalthoff, C.; Hlouschek, Julian; Koska, Benjamin; Vuellings, Manon; Timmermann, Beate; Jendrossek, Verena; Matschke, Johann
    Inhibition of the mitochondrial citrate carrier SLC25A1 induces a DNA repair defect and increases cancer cell radiosensitivity
    26. Jahrestagung der Deutschen Gesellschaft für Radioonkologie (DEGRO) ; 24. - 28. Juni 2020, Wiesbaden, Germany,
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 196, 2020, Nr. 1 Supplement: Abstracts DEGRO 2020, S. S184
  • Hansel, C.; Hlouschek, J.; Helleday, T.; Jendrossek, Verena; Matschke, Johann
    Combined inhibition of GSH levels and sanitization of dNTPs is effective in eradicating cancer cells exposed to acute hypoxia or chronic cycling severe hypoxia
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 194, 2018, Nr. Suppl. 1, S. 172
  • Hlouschek, J.; Hansel, C.; Riffkin, H.; Jendrossek, Verena; Matschke, Johann
    Targeting of antioxidant-associated mitochondrial transport systems overcomes chronic-cycling hypoxia-induced radioresistance
    33. Deutscher Krebskongress - Perspektiven verändern Krebs - Krebs verändert Perspektiven. Diagnose - Therapie - (Über-)Leben ; Berlin, 21.-24. Februar 2018,
    In: Oncology Research and Treatment. Basel: Karger, Jg. 41, 2018, Nr. Suppl. 1, S. 150
  • Hlouschek, J.; Hansel, C.; Jendrossek, Verena; Matschke, Johann
    Targeting of the mitochondrial citrate carrier (SLC25A1) lowers antioxidant defense systems and increases radiosensitivity of hypoxic cancer cells
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 194, 2018, Nr. Suppl. 1, S. 30
  • Shannan, B.; Matschke, Johann; Hoewner, A.; Jendrossek, Verena; Schadendorf, Dirk; Rösch, Alexander
    Senescence-like responses in irradiated melanoma cells
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG). Hoboken: Wiley-Blackwell - STM, Jg. 13, 2015, Nr. Suppl.2, S. 34
  • Matschke, Johann; Riffkin, H.; Handrick, R.; Klein-Hitpaß, Ludger; Jendrossek, Verena
    Chronic intermittent hypoxia triggers adaptive changes that promote protection against cell death
    In: European Journal of Cancer (EJC). Amsterdam: Elsevier, Jg. 50, 2014, Nr. Suppl. 5, S. 51
  • Ontikatze, T.; Matschke, Johann; Grimm, F.; Brost, R.; Moscariello, M.; Iliakis, George; Jendrossek, Verena
    Dihydroartemisinin exerts context-dependent lethal effects in combination with ionizing radiation
    19. Jahreskongress der Deutschen Gesellschaft für Radioonkologie; 9. bis 12. Mai 2013, Berlin,
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 189, 2013, Nr. SUPPL. 1, S. 128 – 129
  • Dissertation

  • Matschke, Johann
    Identifizierung molekularer Mechanismen hypoxie-vermittelter Strahlenresistenz und neue Strategien zu deren pharmakologischer Modulation
    Duisburg, Essen, 2015
  • Habilitation

  • Matschke, Johann
    Metabolische Abhängigkeiten als molekulare Zielstruktur zur Überwindung der Strahlenresistenz
    Duisburg ; Essen, 2024
  • Poster / Posterbeiträge

  • Goetting, I.; Larafa, S.; Eul, K.; Kunin, M.; Jakob, B.; Matschke, Johann; Jendrossek, Verena
    Inhibierung der AKT-abhängigen Regulation der antioxidant defense erhöht die Radiosensitivität von Krebszellen
    28. Kongress der Deutschen Gesellschaft für Radioonkologie ; DEGRO 2022 ; 26. bis 28.05.2022, Stuttgart, Germany,
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 198, 2022, Nr. Supplement 1, S. S157
  • Xiang, K.; Kalthoff, C.; Jendrossek, Verena; Matschke, Johann
    The citrate carrier SLC25A1 acts as regulator of metabolic reprogramming offering an innovative strategy for synthetic lethality approaches with radiotherapy
    28. Kongress der Deutschen Gesellschaft für Radioonkologie ; DEGRO 2022 ; 26. bis 28.05.2022, Stuttgart, Germany,
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 198, 2022, Nr. Supplement 1, S. S152 – S153
  • Kalthoff, Christian; Xiang, Kexu; Muench, Corinna; Hlouschek, Julian; Jendrossek, Verena; Matschke, Johann
    Abstract PO-022: Inhibition of the citrate carrier SLC25A1 affects repair of radiation-induced DNA damage, increases radiosensitivity, and enhances lethality of IR in combination with DNA repair defects or DSB inhibitors
    AACR Virtual Special Conference on Radiation Science and Medicine; March 2-3, 2021, Online,
    In: Clinical Cancer Research. Philadelphia: American Association for Cancer Research (AACR), Jg. 27, 2021, Nr. 8, Supplement, S. PO – 022