Personensuche
Personensuche
Es wurde 1 Person gefunden.
Funktionen
-
Wissenschaftliche/r Mitarbeiter/in, Institut für Zellbiologie (Tumorforschung)
Aktuelle Veranstaltungen
Keine aktuellen Veranstaltungen.
Vergangene Veranstaltungen (max. 10)
Keine vergangenen Veranstaltungen.
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
-
Balancing barriers: Family, career, and gender equality in radiation oncology and radiation research : An interdisciplinary prospective survey among the young workforceIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics, 2025, in pressDOI (Open Access)
-
Targeting hypoxia-inducible factor-1 in a hypoxidative stress model protects retinal pigment epithelium cells from cell death and metabolic dysregulationIn: Cell Death Discovery, Jg. 11, 2025, Nr. 1, 380DOI (Open Access)
-
Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALSIn: Cells, Jg. 13, 2024, Nr. 12, 995DOI (Open Access)
-
German radiation oncology’s next generation : A web-based survey of young biologists, medical physicists, and physicians — from problems to solutionsIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics, Jg. 200, 2024, Nr. 12, S. 1005 – 1024DOI (Open Access)
-
Metabolic pathway-based subtypes associate glycan biosynthesis and treatment response in head and neck cancerIn: npj Precision Oncology, Jg. 8, 2024, Nr. 1, 116DOI (Open Access)
-
α-Ketoglutarate supplementation and NAD+ modulation enhance metabolic rewiring and radiosensitization in SLC25A1 inhibited cancer cellsIn: Cell Death Discovery, Jg. 10, 2024, Nr. 1, 27DOI, Online Volltext (Open Access)
-
A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in GlioblastomaIn: Clinical Cancer Research, Jg. 29, 2023, Nr. 2, S. 488 – 500DOI (Open Access)
-
Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1α under normoxiaIn: Cell Death Discovery, Jg. 9, 2023, Nr. 1, 398DOI, Online Volltext (Open Access)
-
The second PI(3,5)P₂binding site in the S0 helix of KCNQ1 stabilizes PIP₂-at the primary PI1 site with potential consequences on intermediate-to-open state transitionIn: Biological Chemistry, Jg. 404, 2023, Nr. 4, S. 241 – 254
-
Accumulation of oncometabolite D-2-Hydroxyglutarate by SLC25A1 inhibition: A metabolic strategy for induction of HR-ness and radiosensitivityIn: Cell Death and Disease, Jg. 13, 2022, Nr. 7, 641DOI, Online Volltext (Open Access)
-
Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reactionIn: Cell Death and Disease, Jg. 13, 2022, Nr. 7, 662DOI, Online Volltext (Open Access)
-
ROS scavengers decrease γH2ax spots in motor neuronal nuclei of ALS model mice in vitroIn: Frontiers in Cellular Neuroscience, Jg. 16, 2022, 963169DOI (Open Access)
-
Targeting AKT-Dependent Regulation of Antioxidant Defense Sensitizes AKT-E17K Expressing Cancer Cells to Ionizing RadiationIn: Frontiers in Oncology, Jg. 12, 2022, 920017DOI, Online Volltext (Open Access)
-
Adaptation to chronic-cycling hypoxia renders cancer cells resistant to mth1-inhibitor treatment which can be counteracted by glutathione depletionIn: Cells, Jg. 10, 2021, Nr. 11, 3040DOI, Online Volltext (Open Access)
-
Increased ROS-Dependent Fission of Mitochondria Causes Abnormal Morphology of the Cell Powerhouses in a Murine Model of Amyotrophic Lateral SclerosisIn: Oxidative Medicine and Cellular Longevity, Jg. 2021, 2021, 6924251DOI (Open Access)
-
Metabolic reprograming of antioxidant defense : A precision medicine perspective for radiotherapy of lung cancer?In: Biochemical Society Transactions, Jg. 49, 2021, Nr. 3, S. 1265 – 1277
-
Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdownIn: iScience, Jg. 24, 2021, Nr. 11, 103366DOI (Open Access)
-
A new twist in protein kinase b/akt signaling : Role of altered cancer cell metabolism in akt-mediated therapy resistanceIn: International Journal of Molecular Sciences (IJMS), Jg. 21, 2020, Nr. 22, S. 8563DOI, Online Volltext (Open Access)
-
Oncometabolites and the response to radiotherapyIn: Radiation Oncology, Jg. 15, 2020, S. 197DOI, Online Volltext (Open Access)
-
Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End JoiningIn: Cells, Jg. 9, 2020, Nr. 4, 889DOI, Online Volltext (Open Access)
-
Oxidative stress: the lowest common denominator of multiple diseasesIn: Neural Regeneration Research, Jg. 14, 2019, Nr. 2, S. 238 – 241DOI (Open Access)
-
Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV⁶⁰⁰E inhibition in melanomaIn: European Journal of Cancer (EJC), Jg. 109, 2019, S. 137 – 153
-
Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxiaIn: Cancer Letters, Jg. 439, 2018, S. 24 – 38
-
The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe HypoxiaIn: Frontiers in Oncology, Jg. 8, 2018, S. 170DOI, Online Volltext (Open Access)
-
Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxiaIn: Radiation Oncology, Jg. 11, 2016, Nr. 1, S. 75 – 87DOI, Online Volltext (Open Access)
-
Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling HypoxiaIn: Antioxidants and Redox Signaling, Jg. 25, 2016, Nr. 2, S. 89 – 107
-
The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 ChannelsIn: Cellular Physiology and Biochemistry, Jg. 40, 2016, Nr. 6, S. 1549 – 1558DOI (Open Access)
-
Chronic intermittent hypoxia triggers adaptive changes that promote protection against cell deathIn: European Journal of Cancer (EJC), Jg. 49, 2013, Nr. Suppl. 2, S. 101
-
Targeting hypoxia-inducible factor-1 in a hypoxidative stress model protects retinal pigment epithelium cells from cell death and metabolic dysregulation
Europhysiology 2025, 40th Congress of the International Union of Physiological Sciences, 11–14 September 2025, Frankfurt, Germany,In: Acta Physiologica. Weinheim: Wiley-Blackwell, Jg. 241, 2025, Nr. S735, S. 118DOI (Open Access) -
Defects in DNA Damage Response Reinforce Proton Beam Specific Radiosensitivity of Cancer Cells
29. Kongress der Deutschen Gesellschaft für Radioonkologie (DEGRO), 22. bis 24. Juni 2023, Kassel, Germany,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 199, 2023, Nr. Suppl. 1, S. S36 – S37DOI (Open Access) -
Cross-talk of radiotherapy-induced mitochondrial impairment and resulting metabolic reprogramming impact DNA DSB repair capacity
ESTRO 2022: Learning from every patient, 6-10 May 2022, Copenhagen,In: Radiotherapy and Oncology (The Green Journal). Amsterdam: Elsevier, Jg. 170, 2022, Nr. Supplement 1: ESTRO 2022, 6-10 May 2022, Copenhagen. Onsite in Copenhagen and Online, S. S307 -
KDM5B's role in creating radiation synthetic vulnerabilities and its effects on sequential therapy combinations
48th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF): Virtual, Innsbruck, 23-26 February 2022,In: Experimental Dermatology. Hoboken: Wiley, Jg. 31, 2022, Nr. 2, S. e9 – e10 -
Ensuring fuels for DNA repair : Analysis of irradiated cancer cells reveals mitochondrial shutdownIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 197, 2021, Nr. Suppl. 1, S. 200
-
Modeling common aspects of the metabolic response of cancer cells to ionizing radiation
AACR Annual Meeting 2021, April 10-15, 2021 and May 17-21, 2021, Philadelphia, PA, USA,In: Cancer Research. Philadelphia: American Association for Cancer Research (AACR), Jg. 81, 2021, Nr. Suppl. 13, 3065 -
The Role of KDM5B in the Development of radiation-synthetic Vulnerability and its Effect on sequential Therapy CombinationsIn: Journal der Deutschen Dermatologischen Gesellschaft (JDDG). Hoboken: Wiley-Blackwell - STM, Jg. 19, 2021, Nr. Suppl. 4, S. 74
-
The citrate carrier SLC25A1 acts as master regulator of metabolic reprogramming and offers an innovative strategy for metabolic induction of HRness and synthetic lethality approaches with radiotherapyIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 197, 2021, Nr. Suppl. 1, S. 48 – S49
-
Inhibition of the mitochondrial citrate carrier SLC25A1 induces a DNA repair defect and increases cancer cell radiosensitivity
26. Jahrestagung der Deutschen Gesellschaft für Radioonkologie (DEGRO) ; 24. - 28. Juni 2020, Wiesbaden, Germany,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 196, 2020, Nr. 1 Supplement: Abstracts DEGRO 2020, S. S184DOI (Open Access) -
Combined inhibition of GSH levels and sanitization of dNTPs is effective in eradicating cancer cells exposed to acute hypoxia or chronic cycling severe hypoxiaIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 194, 2018, Nr. Suppl. 1, S. 172DOI (Open Access)
-
Targeting of antioxidant-associated mitochondrial transport systems overcomes chronic-cycling hypoxia-induced radioresistance
33. Deutscher Krebskongress - Perspektiven verändern Krebs - Krebs verändert Perspektiven. Diagnose - Therapie - (Über-)Leben ; Berlin, 21.-24. Februar 2018,In: Oncology Research and Treatment. Basel: Karger, Jg. 41, 2018, Nr. Suppl. 1, S. 150DOI (Open Access) -
Targeting of the mitochondrial citrate carrier (SLC25A1) lowers antioxidant defense systems and increases radiosensitivity of hypoxic cancer cellsIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 194, 2018, Nr. Suppl. 1, S. 30DOI (Open Access)
-
Senescence-like responses in irradiated melanoma cellsIn: Journal der Deutschen Dermatologischen Gesellschaft (JDDG). Hoboken: Wiley-Blackwell - STM, Jg. 13, 2015, Nr. Suppl.2, S. 34
-
Chronic intermittent hypoxia triggers adaptive changes that promote protection against cell deathIn: European Journal of Cancer (EJC). Amsterdam: Elsevier, Jg. 50, 2014, Nr. Suppl. 5, S. 51
-
Dihydroartemisinin exerts context-dependent lethal effects in combination with ionizing radiation
19. Jahreskongress der Deutschen Gesellschaft für Radioonkologie; 9. bis 12. Mai 2013, Berlin,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 189, 2013, Nr. SUPPL. 1, S. 128 – 129 -
Identifizierung molekularer Mechanismen hypoxie-vermittelter Strahlenresistenz und neue Strategien zu deren pharmakologischer ModulationDuisburg, Essen, 2015DOI, Online Volltext (Open Access)
-
Metabolische Abhängigkeiten als molekulare Zielstruktur zur Überwindung der StrahlenresistenzDuisburg ; Essen, 2024
-
Inhibierung der AKT-abhängigen Regulation der antioxidant defense erhöht die Radiosensitivität von Krebszellen
28. Kongress der Deutschen Gesellschaft für Radioonkologie ; DEGRO 2022 ; 26. bis 28.05.2022, Stuttgart, Germany,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 198, 2022, Nr. Supplement 1, S. S157DOI (Open Access) -
The citrate carrier SLC25A1 acts as regulator of metabolic reprogramming offering an innovative strategy for synthetic lethality approaches with radiotherapy
28. Kongress der Deutschen Gesellschaft für Radioonkologie ; DEGRO 2022 ; 26. bis 28.05.2022, Stuttgart, Germany,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 198, 2022, Nr. Supplement 1, S. S152 – S153DOI (Open Access) -
Abstract PO-022: Inhibition of the citrate carrier SLC25A1 affects repair of radiation-induced DNA damage, increases radiosensitivity, and enhances lethality of IR in combination with DNA repair defects or DSB inhibitors
AACR Virtual Special Conference on Radiation Science and Medicine; March 2-3, 2021, Online,In: Clinical Cancer Research. Philadelphia: American Association for Cancer Research (AACR), Jg. 27, 2021, Nr. 8, Supplement, S. PO – 022DOI (Open Access)