Publikationen AG Rauen


1. Gröger M, Dinger J, Kiehntopf M, Peters FT, Rauen U, Mosig AS.
Preservation of cell structure, metabolism, and biotransformation activity of liver-on-chip organ models by hypothermic storage.
Adv Healthcare Mater 7, doi: 10.1002/adhm.201700616 (2018)

2. Pless-Petig G, Rauen U.
Serum-free cryopreservation of primary rat hepatocytes in a modified cold storage solution – Improvement of cell attachment and function.
Biopreserv Biobank (im Druck)

3. Lautenschläger I, Pless-Petig G, Middel P, de Groot H, Rauen U, Stojanovic T.
Cold-storage injury to rat small-bowel transplants – beneficial effect of a modified HTK solution.
Transplantation (im Druck)

4. Helfritz FA, Bojkova D, Wanders V, Kuklinski N, Westhaus S, von Horn C, Rauen U, Gallinat A, Baba HA, Skyschally A, Swoboda S, Kinast V, Steinmann E, Heusch G, Minor T, Meuleman P, Paul A, Ciesek S.
Methylene blue treatment of grafts during cold ischemia time reduces the risk of HCV transmission.
J Infect Dis (im Druck)

5. Pless-Petig G, Knoop S, Rauen U.
Serum- and albumin-free cryopreservation of endothelial monolayers with a new solution.
Organogenesis (im Druck)



1. Bienholz A, Walter B, Pless-Petig G, Guberina H, Kribben A, Witzke O, Rauen U.
Characterization of injury in isolated rat proximal tubules during cold incubation and rewarming.
PLoS One 12, e0180553 (2017)

2. Bienholz A, Pang RM, Guberina H, Rauen U, Witzke O, Wilde B, Petrat F, Feldkamp T, Kribben A.
Resveratrol does not protect from ischemia-induced acute kidney injury in an in vitro rat model.
Kidney Blood Press Res 42, 1090-1103 (2017)

3. Pless-Petig G, Walter B, Bienholz A, Rauen U.
Mitochondrial impairment as a key factor for the lack of attachment after cold storage of hepatocyte suspensions.
Cell Transplant 26, 1855-67 (2017)



1. Hoyer DP, Mathé Z, Gallinat A, Canbay A, Treckmann J, Rauen U, Paul A, Minor T.
Controlled oxygenated rewarming of cold stored livers prior transplantation: First clinical application of a new concept.
Transplantation 100, 147-52 (2016)



1. Minor T, Paul A, Efferz P, Wohlschlaeger J, Rauen U, Gallinat A.
Kidney transplantation after oxygenated machine perfusion preservation with Custodiol-N solution.
Transpl Int 28, 1102-8 (2015)



1. Hoyer DP, Gallinat A, Swoboda S, Wohlschläger J, Rauen U, Paul A, Minor T.
Influence of oxygen concentration during hypothermic machine perfusion on porcine kidneys from donation after circulatory death.
Transplantation 98, 944-50 (2014)

2. Hoyer DP, Gallinat A, Swoboda S, Wohlschläger J, Rauen U, Paul A, Minor T.
Subnormothermic machine perfusion for preservation of porcine kidneys in a donation after circulatory death model.
Transpl Int 27, 1097-106 (2014)


1. Sydor S, Gu Y, Schlattjan M, Bechmann LP, Rauen U, Best J, Paul A, Baba HA, Sowa JP, Gerken G, Canbay A.
Steatosis does not impair liver regeneration after partial hepatectomy.
Lab Invest 93, 20-30 (2013)

2. Gallinat A, Lüer B, Swoboda S, Rauen U, Paul A, Minor T.
Use of the new preservation solution Custodiol-N supplemented with dextran for hypothermic machine perfusion of the kidney. Cryobiology 66, 131-5 (2013)

3. Hagemann S, Wohlschlaeger J, Bertram S, Levkau B, Musacchio A, Conway EM, Moellmann D, Kneiseler G, Pless-Petig G, Lorenz K, Sitek B, Baba HA.
Loss of Survivin influences liver regeneration and is associated with impaired Aurora B function.
Cell Death Differ 20, 834-44 (2013)



1. Pless G, Sauer IM, Rauen U.
Improvement of the cold storage of isolated human hepatocytes.
Cell Transplant 21, 23-37 (2012)

2. Pizanis N, Petrov A, Heckmann J, Wiswedel I, Wohlschläger J, de Groot H, Jakob H, Rauen U, Kamler M.
A new preservation solution for lung transplantation. Evaluation in a porcine transplantation model.
J Heart Lung Transplant 31, 310-7 (2012)

3. Vandana S, Sustmann R, Rauen U, Stöhr C.
FNOCT as a fluorescent probe for in vivo localization of nitric oxide distribution in tobacco roots.
Plant Physiol Biochem 59, 80-9 (2012)

4. Türk TR, Su S, Rauen U, Feldkamp T, de Groot H, Kribben A, Witzke O.
Reduction of chronic graft injury with a new HTK-based preservation solution in a murine heart transplantation model.
Cryobiology 64, 273-8 (2012)

5. Pless-Petig G, Singer BB, Rauen U.
Cold storage of rat hepatocyte suspensions for one week in a customized
cold storage solution — preservation of cell attachment and metabolism.
PLoS One 7 (7), e40444 (2012)

6. Pless-Petig G, Metzenmacher M, Türk TR, Rauen U.
Aggravation of cold-induced injury in Vero-B4 cells by RPMI 1640 medium —
Identification of the responsible medium components.
BMC Biotechnol 12, 73 (2012)

7. Liu Q, Bruns H, Schultze D, Xue Y, Zorn M, Flechtenmacher C, Straub BK, Rauen U, Schemmer P.
HTK-N, a modified HTK solution, decreases preservation injury in a model of microsteatotic rat liver transplantation.
Langenbecks Arch Surg 397, 1323-31 (2012)



1. Wu K, Türk TR, Rauen U, Su S, Feldkamp T, de Groot H, Wiswedel I, Baba HA, Kribben A, Witzke O.
Prolonged cold storage using a new histidine-tryptophan-ketoglutarate-based preservation solution in isogeneic cardiac mouse grafts.
Eur Heart J 32, 509-516 (2011)

2. Garbe S, Zatschler B, Müller B, Dietrich P, Ebner A, Rauen U, Matschke K, Deussen A.
Preservation of human artery function following prolonged cold storage with a new solution.
J Vasc Surg 53, 1057-1064 (2011)

3. Fingas CD, Wu S, Gu Y, Wohlschlaeger J, Scherag A, Dahmen U, Paul A, de Groot H, Rauen U.
Assessment of a chloride-poor vs. a chloride-containing modified HTK solution in a rat liver transplantation model.
Liver Transplantation 17, 650-660 (2011)

4. Wille T, Gonder S, Thiermann H, Seeger T, Rauen U, Worek F.
Evaluation of functional and structural alterations in muscle tissue after short-term cold storage in a new tissue preservation solution.
Cells Tissues Organs 194, 501-509 (2011)

5. Pizanis N, Gillner S, Kamler M, de Groot H, Jakob H, Rauen U.
Cold-induced injury to lung epithelial cells can be inhibited by iron chelators - implications for lung preservation.
Eur J Cardiothorac Surg 40, 948-955 (2011)



1. Benko T, Frede S, Gu Y, Best J, Baba HA, Schlaak JF, de Groot H, Fandrey J, Rauen U.
Glycine pretreatment ameliorates liver injury after partial hepatectomy in the rat.
J Invest Surg 23, 12-20 (2010)

2. Stegemann J, Hirner A, Rauen U, Minor T.
Use of a new modified HTK solution for machine preservation of marginal liver grafts.
J Surg Res 160, 155-162 (2010)

3. Düppe PM, Talbierski PM, Hornig FS, Rauen U, Korth HG, Wille T, Boese R, Omlor T, de Groot H, Sustmann R. 
Pyrene-based fluorescent nitric oxide cheletropic traps (FNOCTs) for the detection of nitric oxide (NO) in cell cultures and tissues.
Chemistry 16, 11121-11132 (2010)

4. Wille T, Rauen U.
Eine neue Lösung zur kalten Lagerung von Blutgefäßen.
Gefäßchirurgie 15, 442-447 (2010)

5. Heuer M, Reinhardt R, Kneiseler G, Würzinger P, Zou X, Hua F, Jian F, Paul A, Kaiser GM.
Liver transplantation in swine without venovenous bypass.
Eur Surg Res 45, 20-25 (2010)



1. Stegemann J,  Hirner A, Rauen U, Minor T.
Gaseous oxygen persufflation of oxygenated machine perfusion with Custodiol-N for long-term preservation of ischemic rat livers?
Cryobiology 58, 45-51 (2009)

2. Wu S, Wohlschlaeger J, de Groot H, Rauen U.
Evaluation of a modified HTK solution containing the new iron chelator LK 614 in an isolated rat liver perfusion model.
J Invest Surg 22, 340-347 (2009)

3. Rauen U, Kettler-Thiel T, de Groot H, Korth HG, Sustmann R.
Conversion of the synthetic catalase mimic precursor TAA-1 into the active catalase mimic in isolated hepatocytes.
Chem Biol Drug Des 73, 494-501 (2009)

4. Bramey T, Freitag P, Fandrey J, Rauen U, Pamp K, Erhard J, Frede S, de Groot H, Petrat F.
No evidence for protective erythropoietin alpha signalling in rat hepatocytes.
BMC Gastroenterology 9, 26 (2009)

5. Zatschler B, Dieterich P, Müller B, Kasper M, Rauen U, Deussen A.
Improved vessel preservation after 4 days cold storage. Experimental study in rat arteries.
J Vasc Surg 50, 397-406 (2009)



1. Rauen U, de Groot H.
Inherent toxicity of organ preservation solutions to cultured hepatocytes.
Cryobiology 56, 88-92 (2008)

2. Wille T, de Groot H, Rauen U.
Improvement of the cold storage of blood vessels with a vascular preservation solution. Study in porcine aortic segments.
J Vasc Surg 47, 422-31 (2008)

3. Wusteman M, Rauen U, Simmonds J, Hunds N, Pegg DE.
Reduction of cryoprotectant toxicity in cells in suspension by use of a sodium-free vehicle solution.
Cryobiology 56, 72-9 (2008)

4. Bahde R, Palmes D, Gemsa O, Minin E, Stratmann U, de Groot H, Rauen U, Spiegel HU.
Attenuated cold storage injury of rat livers using a modified HTK solution.
J Surg Res 146, 49-56 (2008)

5. Knoop S, de Groot H, Rauen U.
Little evidence for a major role of Ca2+ in cold-induced injury of liver cells.
Cryobiology 56, 103-13 (2008)

6. Radovits T, Lin LN, Zotkina J, Koch A, Rauen U, Köhler G, Karck M, Szabó G.
Endothelial dysfunction after long-term cold storage in HTK organ preservation solutions: effects of iron chelators and N-alpha-acetyl-L-histidine.
J Heart Lung Transplant. 27, 208-16 (2008)

7. Pamp K,  Kerkweg U, Korth HG, Homann F, Rauen U, Sustmann R, de Groot H, Petrat F.
Enzymatic reduction of labile iron by organelles of the rat liver. Superior role of an NADH-dependent activity in the outer mitochondrial membrane. Biochimie 90, 1591-601 (2008)

8. Sowa JP, Best J, Benko T, Bockhorn M, Gu Y, Niehues EM, Bucchi A, Benedetto-Castro EM, Gerken G, Rauen U, Schlaak JF.
Extent of liver resection modulates the activation of transcription factors and the production of cytokines involved in liver regeneration.
World J Gastroenterol 14, 7093-7100 (2008)

9. Bockhorn M, Fingas C, Rauen U, Canbay A, Frey U, Shen SY, Wohlschläger J, Sotiropoulos G, Broelsch C, Schlaak J.
Erythropoietin treatment improves liver regeneration and survival in rat models of extended liver resection and living donor liver transplantation.
Transplantation 86, 1578-85 (2008)



1. Rauen U, Springer A, Weisheit D, Petrat F, Korth HG, de Groot H, Sustmann R.
Asessment of chelatable mitochondrial iron using mitochondria-selective fluorescent iron indicators with different iron-binding affinity.
Chembiochem. 8, 341-352 (2007)

2. Rauen U, Kerkweg U, de Groot H.
Iron-dependent vs. iron-independent cold-induced injury to cultured rat hepatocytes: a comparative study in physiological media and organ preservation solutions.
Cryobiology 54, 77-86 (2007)

3. Rauen U, Klempt S, de Groot H.
Histidine-induced injury to cultured liver cells, effects of histidine derivatives and of iron chelators.
Cell. Mol. Life Sci. 64, 192-205 (2007)

4. Lange R, Rauen U, Janßen H, Erhard J, de Groot H.
Temporary heterotopic auxiliary liver transplantation with arterialization of the portal vein as treatment of acute liver failure.
Transpl. Int. 20, 473-474 (2007)

5. Rauen U, Li T, Ioannidis I, de Groot H.
Nitric oxide increases toxicity of hydrogen peroxide against rat liver endothelial cells and hepatocytes by inhibition of hydrogen peroxide degradation.
Am. J. Physiol. Cell Physiol. 292, C1440-C1449 (2007)

6. Rauen U, Li T, de Groot H.
Inhibitory and enhancing effects of NO on H2O2 toxicity: dependence on the concentrations of NO and H2O2.
Free Radic. Res. 41, 402-412 (2007)

7. Schröder C, Heintz A, Pexa A, Rauen U, Deussen A.
Preclinical evaluation of coronary vascular function after cardioplegia with HTK and different antioxidant additives.
Eur. J. Cardiothorac. Surg. 31, 822-827 (2007)

8. de Groot H, Rauen U.
Ischemia-reperfusion injury: processes in pathogenetic networks: a review.
Transplant. Proc. 39, 481-484 (2007)