Zellschädigung durch Eisen und reaktive Sauerstoffspezies


Projektrelevante Publikationen:


Rauen U, Kettler-Thiel T, de Groot H, Korth H-G, Sustmann R.
Conversion of the synthetic catalase mimic precursor TAA-1 into the active catalase mimic in isolated hepatocytes.
Chem Biol Drug Des 73, 494-501 (2009)

Rauen U, Li T, Ioannidis I, de Groot H.
Nitric oxide increases toxicity of hydrogen peroxide against rat liver endothelial cells and hepatocytes by inhibition of hydrogen peroxide degradation.
Am J Physiol Cell Physiol 292, C1440-1449 (2007)

Rauen U, Li T, de Groot H.
Inhibitory and enhancing effects of NO on H2O2 toxicity: dependence on the concentrations of NO and H2O2.
Free Radic Res 41, 402-412 (2007)

Rauen U, Petrat F, Sustmann R, de Groot H.
Eisen und Zellschädigung. In: Hämochromatosen – Hämosiderosen.
Erhardt A, Häussinger D (Hrsg.).
Bremen, UNI-MED Verlag, 34-45 (2006)

Petrat F, Li T, Dehne N, de Groot H, Rauen U.
Sodium as the major mediator of NO-induced cell death in cultured hepatocytes.
Life Sci 79, 1606-1615 (2006)

Sturm B, Bistrich U, Schranzhofer M, Sarsero JP, Rauen U, Scheiber-Mojdehkar B, de Groot H, Ioannou P, Petrat F.
Friedreich´s ataxia, no changes in mitochondrial labile iron in human lymphoblasts and fibroblasts. A decrease in antioxidative capacity?
J Biol Chem 280, 6701-6708 (2005)

Rauen U, Petrat F, Sustmann R, de Groot H.
Iron-induced mitochondrial permeability transition in cultured hepatocytes.
J Hepatol 40, 607-615 (2004)

Dehne N, Li T, Petrat F, Rauen U, de Groot H.
Critical O2  and NO concentrations in NO-induced cell death in a rat liver sinusoidal endothelial cell line.
Biol Chem 385, 341-349 (2004)

Rauen U, Li T, Sustmann R, de Groot H.
Protection against iron- and hydrogen peroxide-dependent cell injuries by a novel synthetic iron catalase mimic and its precursor, the iron-free ligand.
Free Radic Biol Med 37, 1369-1383 (2004)

Petrat F, de Groot H, Sustmann R, Rauen U.
The chelatable iron pool in living cells: a methodically defined quantity.
Biol Chem 383, 489-502 (2002)

Dehne N, Rauen U, de Groot H, Lautermann J.
Involvement of the mitochondrial permeability transition in gentamicin ototoxicity.
Hear Res 169, 47-55 (2002)

Lehnen-Beyel I, de Groot H, Rauen U.
Enhancement of iron toxicity in L929 cells by D-glucose: accelerated (re-)reduction.
Biochem J 368, 517-526 (2002)

Petrat F, de Groot H, Rauen U.
Subcellular distribution of chelatable iron: A laser scanning microscopic study in isolated hepatocytes and liver endothelial cells.
Biochem J 356, 61-69 (2001)