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Fakultät für Chemie
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S07 S00 C21
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Universitätsprofessor/in em./i.R., Organische Chemie
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2010 WS
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2009 WS
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Molecular Tweezers : Supramolecular Hosts with Broad-Spectrum Biological ApplicationsIn: Pharmacological Reviews Jg. 75 (2023) Nr. 2, S. 263 - 308ISSN: 1521-0081; 0031-6997Online Volltext: dx.doi.org/
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Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory VirusesIn: JACS Au Jg. 2 (2022) Nr. 9, S. 2187 - 2202ISSN: 2691-3704Online Volltext: dx.doi.org/ (Open Access)
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Correction to : The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic miceIn: Alzheimer's Research & Therapy Jg. 13 (2021) Nr. 1, S. 88ISSN: 1758-9193Online Volltext: dx.doi.org/ (Open Access)
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Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezersIn: Cell Chemical Biology Jg. 28 (2021) Nr. 9, S. 1310 - 1320.e5ISSN: 2451-9448; 2451-9456Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomesIn: Communications Biology Jg. 4 (2021) Nr. 1,ISSN: 2399-3642Online Volltext: dx.doi.org/ (Open Access)
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The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic miceIn: Alzheimer's Research & Therapy Jg. 13 (2021) Nr. 1, S. 6ISSN: 1758-9193Online Volltext: dx.doi.org/ (Open Access)
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CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s diseaseIn: Nature Communications Jg. 11 (2020) Nr. 1, S. 4885ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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Chirality sensing of terpenes, steroids, amino acids, peptides and drugs with acyclic cucurbit[: N] urils and molecular tweezersIn: Chemical Communications: ChemComm Jg. 56 (2020) Nr. 34, S. 4652 - 4655ISSN: 1364-548X; 1359-7345Online Volltext: dx.doi.org/ (Open Access)
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Different Inhibitors of Aβ42-Induced Toxicity Have Distinct Metal-Ion DependencyIn: ACS Chemical Neuroscience Jg. 11 (2020) Nr. 15, S. 2243 - 2255ISSN: 1948-7193Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Supramolecular Mechanism of Viral Envelope Disruption by Molecular TweezersIn: Journal of the American Chemical Society: JACS Jg. 142 (2020) Nr. 40, S. 17024 - 17038ISSN: 0002-7863; 1520-5126Online Volltext: dx.doi.org/ (Open Access)
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The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage DiseaseIn: Molecular Therapy Jg. 28 (2020) Nr. 4, S. 1167 - 1176ISSN: 1525-0024; 1525-0016Online Volltext: dx.doi.org/ (Open Access)
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Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential InhibitorsIn: ACS Chemical Biology Jg. 14 (2019) Nr. 6, S. 1363 - 1379ISSN: 1554-8937; 1554-8929Online Volltext: dx.doi.org/ (Open Access)
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Molecular lysine tweezers counteract aberrant protein aggregationIn: Frontiers in Chemistry Jg. 7 (2019)ISSN: 2296-2646Online Volltext: dx.doi.org/ (Open Access)
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Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly ModulatorIn: Journal of the American Society for Mass Spectrometry Jg. 30 (2019) Nr. 1, S. 16 - 23ISSN: 1879-1123; 1044-0305Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALSIn: The Journal of Biological Chemistry (JBC) Jg. 294 (2019) Nr. 10, S. 3501 - 3513ISSN: 0021-9258; 1083-351XOnline Volltext: dx.doi.org/ Online Volltext (Open Access)
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The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophyIn: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Jg. 1865 (2019) Nr. 11, S. 165513ISSN: 1879-260X; 0925-4439Online Volltext: dx.doi.org/ (Open Access)
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Molecular tweezers with additional recognition sitesIn: Chemistry - A European Journal Jg. 24 (2018) Nr. 44, S. 11332 - 11343ISSN: 0947-6539; 1521-3765Online Volltext: dx.doi.org/
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A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-SynucleinIn: Neurotherapeutics Jg. 14 (2017) Nr. 4, S. 1107 - 1119ISSN: 1878-7479; 1933-7213Online Volltext: dx.doi.org/
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Fritz Vögtle (1939-2017)In: Angewandte Chemie International Edition Jg. 56 (2017) Nr. 14, S. 3751 - 3752ISSN: 1521-3773; 1433-7851; 0570-0833Online Volltext: dx.doi.org/
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Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01In: Journal of the American Chemical Society: JACS Jg. 139 (2017) Nr. 16, S. 5640 - 5643ISSN: 0002-7863; 1520-5126Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Inhibition of Mutant αB Crystallin‐Induced Protein Aggregation by a Molecular TweezerIn: Journal of the American Heart Association Jg. 6 (2017) S. e006182ISSN: 2047-9980Online Volltext: dx.doi.org/ (Open Access)
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Molecular tweezers inhibit PARP-1 by a new mechanismIn: European Journal of Organic Chemistry (2017) Nr. 16, S. 2223 - 2229ISSN: 1099-0690; 0075-4617; 0170-2041; 0365-5490; 0947-3440; 1434-193X; 1434-243XOnline Volltext: dx.doi.org/
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Anthraphane : An Anthracene-Based, Propeller-Shaped D3h-Symmetric Hydrocarbon Cyclophane and Its Layered Single Crystal StructuresIn: The Journal of Organic Chemistry Jg. 81 (2016) Nr. 6, S. 2572 - 2580ISSN: 1520-6904; 0022-3263Online Volltext: dx.doi.org/
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Molecular tweezers for lysine and arginine : powerful inhibitors of pathologic protein aggregationIn: Chemical Communications: ChemComm Jg. 52 (2016) Nr. 76, S. 11318 - 11334ISSN: 1364-548X; 0009-241X; 0022-4936; 1359-7345Online Volltext: dx.doi.org/ (Open Access)
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Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish EmbryosIn: Environmental Health Perspectives Jg. 124 (2016) Nr. 11, S. 1766 - 1775ISSN: 0091-6765; 1552-9924Online Volltext: dx.doi.org/ (Open Access)
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Reducing synuclein accumulation improves neuronal survival after spinal cord injuryIn: Experimental Neurology Jg. 278 (2016) S. 105 - 115ISSN: 1090-2430; 0014-4886Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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A molecular tweezer antagonizes seminal amyloids and HIV infectionIn: eLife Jg. 4 (2015) Nr. 8, S. e05397ISSN: 2050-084XOnline Volltext: dx.doi.org/ (Open Access)
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Amyloid β-Protein Assembly : The Effect of Molecular Tweezers CLR01 and CLR03In: Journal of Physical Chemistry B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical Chemistry Jg. 119 (2015) Nr. 14, S. 4831 - 4841ISSN: 1520-6106; 1089-5647; 1520-5207Online Volltext: dx.doi.org/ (Open Access)
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Molecular tweezers inhibit islet amyloid polypeptide assembly and toxicity by a new mechanismIn: ACS Chemical Biology Jg. 10 (2015) Nr. 6, S. 1555 - 1569ISSN: 1554-8937; 1554-8929Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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The lys-specific molecular tweezer, CLR01, modulates aggregation of the mutant p53 DNA binding domain and inhibits its toxicityIn: Biochemistry Jg. 54 (2015) Nr. 24, S. 3729 - 3738ISSN: 1520-4995; 0006-2960Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Toxicity inhibitors protect lipid membranes from disruption by Aβ42In: ACS Chemical Neuroscience Jg. 6 (2015) Nr. 11, S. 1860 - 1869ISSN: 1948-7193Online Volltext: dx.doi.org/
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Molecular Basis for Preventing α-Synuclein Aggregation by a Molecular TweezerIn: The Journal of Biological Chemistry (JBC) Jg. 289 (2014) Nr. 5, S. 10727 - 10737ISSN: 0021-9258; 1083-351XOnline Volltext: dx.doi.org/
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Molecular Tweezers Targeting Transthyretin AmyloidosisIn: Neurotherapeutics Jg. 11 (2014) Nr. 2, S. 450 - 461ISSN: 1878-7479; 1933-7213Online Volltext: dx.doi.org/ (Open Access)
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Safety and pharmacological characterization of the molecular tweezer CLR01 – a broad-spectrum inhibitor of amyloid proteins’ toxicityIn: BMC Pharmacology and Toxicology Jg. 15 (2014) S. 23ISSN: 2050-6511; 1472-6904Online Volltext: dx.doi.org/ (Open Access)
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Aromatic interactions by molecular tweezers and clips in chemical and biological systemsIn: Accounts of Chemical Research Jg. 46 (2013) Nr. 4, S. 967 - 978ISSN: 0001-4842; 1520-4898Online Volltext: dx.doi.org/
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Ditopic arginine-aspartate binders recognize RGD loopsIn: European Journal of Organic Chemistry (2013) Nr. 6, S. 1080 - 1092ISSN: 1099-0690; 0075-4617; 0170-2041; 0365-5490; 0947-3440; 1434-193X; 1434-243XOnline Volltext: dx.doi.org/
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Linker effects on amino acid and peptide recognition by molecular tweezersIn: European Journal of Organic Chemistry (2013) Nr. 34, S. 7705 - 7714ISSN: 1099-0690; 0075-4617; 0170-2041; 0365-5490; 0947-3440; 1434-193X; 1434-243XOnline Volltext: dx.doi.org/
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Molecular Tweezers with Varying Anions : A Comparative StudyIn: The Journal of Organic Chemistry Jg. 78 (2013) Nr. 13, S. 6721 - 6734ISSN: 1520-6904; 0022-3263Online Volltext: dx.doi.org/
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Molecular tweezers modulate 14-3-3 protein–protein interactionsIn: Nature Chemistry Jg. 5 (2013) Nr. 3, S. 234 - 239ISSN: 1755-4349; 1755-4330Online Volltext: dx.doi.org/
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Polyglycerol-tagged molecular clips as receptors in protic solventsIn: European Journal of Organic Chemistry (2013) Nr. 2, S. 362 - 367ISSN: 1099-0690; 0075-4617; 0170-2041; 0365-5490; 0947-3440; 1434-193X; 1434-243XOnline Volltext: dx.doi.org/
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Synthesis of Shape-Persistent Macrocycles with Three 1,8-Diazaanthracene Units and Their Packing in the Single CrystalIn: Chemistry - A European Journal Jg. 19 (2013) Nr. 40, S. 13348 - 13354ISSN: 0947-6539; 1521-3765Online Volltext: dx.doi.org/
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A Novel "Molecular Tweezer" Inhibitor of α-Synuclein Neurotoxicity in Vitro and in VivoIn: Neurotherapeutics Jg. 9 (2012) Nr. 2, S. 464 - 476ISSN: 1878-7479; 1933-7213Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Comparison of Three Amyloid Assembly Inhibitors : The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01In: ACS Chemical Neuroscience Jg. 3 (2012) Nr. 6, S. 451 - 458ISSN: 1948-7193Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Diazapyrenium cored dendrimers : electron poor guests for a molecular clip hostIn: New Journal of Chemistry Jg. 36 (2012) Nr. 2, S. 354 - 359ISSN: 1369-9261; 1144-0546Online Volltext: dx.doi.org/
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Donor/acceptor-substituted chiral molecular clips - Synthesis and host-guest complex formationIn: European Journal of Organic Chemistry (2012) Nr. 18, S. 3385 - 3395ISSN: 1099-0690; 0075-4617; 0170-2041; 0365-5490; 0947-3440; 1434-193X; 1434-243XOnline Volltext: dx.doi.org/
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Erratum to: A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity In Vitro and In VivoIn: Neurotherapeutics Jg. 9 (2012) Nr. 2, S. 486ISSN: 1878-7479; 1933-7213Online Volltext: dx.doi.org/
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Protection of primary neurons and mouse brain from Alzheimer’s pathology by molecular tweezersIn: Brain: A Journal of Neurology Jg. 135 (2012) Nr. 12, S. 3735 - 3748ISSN: 0006-8950; 1460-2156Online Volltext: dx.doi.org/
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A molecular clip throws new light on the complexes formed by a family of cyclam-cored dendrimers with Zn(II) ions : Efficient energy transfer in the heteroleptic complexesIn: Dalton Transactions Jg. 40 (2011) Nr. 6, S. 1356 - 1364ISSN: 1477-9234; 1477-9226Online Volltext: dx.doi.org/
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Emanuel Vogel (1927-2011)In: Nachrichten aus der Chemie Jg. 59 (2011) Nr. 6, S. 655ISSN: 1439-9598; 1868-0054Online Volltext: dx.doi.org/
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Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteinsIn: Journal of the American Chemical Society: JACS Jg. 133 (2011) Nr. 42, S. 16958 - 16969ISSN: 0002-7863; 1520-5126Online Volltext: dx.doi.org/
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Non covalent inclusion of nucleosides and nucleotides in water-soluble molecular clipsIn: Heterocycles Jg. 82 (2011) Nr. 2, S. 1549 - 1566ISSN: 0385-5414; 1881-0942Online Volltext: dx.doi.org/
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[Obituary] William von Eggers DoeringIn: Angewandte Chemie International Edition Jg. 50 (2011) Nr. 13, S. 2885 - 2886ISSN: 1521-3773; 1433-7851; 0570-0833Online Volltext: dx.doi.org/
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A Light-Harvesting Antenna Resulting from the Self-Assembly of Five Luminescent Components : A Dendrimer, Two Clips, and Two Lanthanide IonsIn: Chemistry - A European Journal Jg. 16 (2010) Nr. 20, S. 6048 - 6055ISSN: 0947-6539; 1521-3765Online Volltext: dx.doi.org/
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Effect of molecular clips and tweezers on enzymatic reactions by binding coenzymes and basic amino acidsIn: Pure and Applied Chemistry Jg. 82 (2010) Nr. 4, S. 991 - 999ISSN: 0033-4545; 1365-3075Online Volltext: dx.doi.org/
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Intramolecular Electronic Interactions between Nonconjugated Arene and Quinone ChromophoresIn: Journal of the American Chemical Society: JACS Jg. 132 (2010) Nr. 25, S. 8581 - 8592ISSN: 0002-7863; 1520-5126Online Volltext: dx.doi.org/
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Metal ion driven formation of a light-harvesting antenna investigated by sensitized luminescence and fluorescence anisotropyIn: Chemical Communications: ChemComm Jg. 46 (2010) Nr. 20, S. 3571 - 3573ISSN: 1364-548X; 0009-241X; 0022-4936; 1359-7345Online Volltext: dx.doi.org/
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Structure of Molecular Tweezer Complexes in the Solid State : NMR Experiments, X-ray Investigations, and Quantum Chemical Calculations.In: Journal of the American Chemical Society: JACS Jg. 129 (2007) Nr. 5, S. 1293 - 1303ISSN: 0002-7863; 1520-5126Online Volltext: dx.doi.org/
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Dynamics in Host–Guest Complexes of Molecular Tweezers and ClipsIn: Chemistry - A European Journal Jg. 12 (2006) Nr. 6, S. 1629 - 1641ISSN: 0947-6539; 1521-3765Online Volltext: dx.doi.org/
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Molecular Tweezer and Clip in Aqueous Solution: Unexpected Self-Assembly, Powerful Host-Guest Complex Formation, Quantum Chemical 1H NMR Shift Calculation.In: Journal of the American Chemical Society: JACS Jg. 128 (2006) Nr. 14, S. 4831 - 4841ISSN: 0002-7863; 1520-5126Online Volltext: dx.doi.org/
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Nucleoside sensing.In: Sensors Jg. 6 (2006) Nr. 8, S. 860 - 873ISSN: 1424-8220Online Volltext: dx.doi.org/ (Open Access)
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A Molecular Tweezer for Lysine and ArginineIn: Journal of the American Chemical Society: JACS Jg. 127 (2005) Nr. 41, S. 14415 - 14421ISSN: 0002-7863; 1520-5126Online Volltext: dx.doi.org/
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Inclusion of Thiamine Diphosphate and S-Adenosylmethionine at Their Chemically Active SitesIn: The Journal of Organic Chemistry Jg. 70 (2005) Nr. 25, S. 10227 - 10237ISSN: 1520-6904; 0022-3263Online Volltext: dx.doi.org/
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Selective Complexation of N-Alkylpyridinium Salts : Binding of NAD+ in WaterIn: Chemistry - A European Journal Jg. 11 (2005) Nr. 2, S. 477 - 494ISSN: 0947-6539; 1521-3765Online Volltext: dx.doi.org/
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Effect of Substituents on the Complexation of Aromatic and Quinoid Substrates with Molecular Tweezers and ClipsIn: European Journal of Organic Chemistry (2004) Nr. 7, S. 1405 - 1423ISSN: 1099-0690; 0075-4617; 0170-2041; 0365-5490; 0947-3440; 1434-193X; 1434-243XOnline Volltext: dx.doi.org/
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Synthesis and Supramolecular Properties of Trimethylene-Bridged ClipsIn: Chemistry - A European Journal Jg. 9 (2003) Nr. 20, S. 5036 - 5047ISSN: 0947-6539; 1521-3765Online Volltext: dx.doi.org/
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Selective Complexation of N-Alkylpyridinium Salts : Recognition of NAD+ in WaterIn: Angewandte Chemie International Edition Jg. 41 (2002) Nr. 8, S. 1355 - 1358ISSN: 1521-3773; 1433-7851; 0570-0833Online Volltext: dx.doi.org/
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Molecular tweezers as synthetic receptors: molecular recognition of neutral and cationic aromatic substrates : A comparison between the supramolecular structures in crystal and in solutionIn: Journal of Physical Organic Chemistry Jg. 13 (2000) Nr. 10, S. 604 - 611ISSN: 0894-3230; 1099-1395Online Volltext: dx.doi.org/
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Molecular Tweezers as Synthetic Receptors : Molecular Recognition of Electron-Deficient Aromatic and Aliphatic SubstratesIn: Chemistry - A European Journal Jg. 5 (1999) Nr. 6, S. 1700 - 1707ISSN: 0947-6539; 1521-3765Online Volltext: dx.doi.org/
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Pressure-Induced Cycloadditions of Dicyanoacetylene to Strained Arenes : The Formation of Cyclooctatetraene, 9,10-Dihydronaphthalene, and Azulene Derivatives; A Degenerate [1,5] Sigmatropic Shift—Comparison between Theory and ExperimentIn: Chemistry - A European Journal Jg. 5 (1999) Nr. 7, S. 2119 - 2132ISSN: 0947-6539; 1521-3765Online Volltext: dx.doi.org/
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Structural Aspects of Cyclopropyl Homoconjugation : Experimental Studies and Ab Initio CalculationsIn: Liebigs Annalen/Recueil (1997) Nr. 7, S. 1429 - 1435ISSN: 0170-2041Online Volltext: dx.doi.org/
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Synthesis of sterically rigid macrocycles by the use of pressure-induced repetitive Diels-Alder reactionsIn: Liebigs Annalen/Recueil (1997) Nr. 3, S. 501 - 516ISSN: 0170-2041Online Volltext: dx.doi.org/
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Molecular Tweezers as Synthetic Receptors in Host—Guest Chemistry : Inclusion of Cyclohexane and Self-Assembly of Aliphatic Side ChainsIn: Angewandte Chemie International Edition Jg. 35 (1996) Nr. 10, S. 1130 - 1133ISSN: 1521-3773; 1433-7851; 0570-0833Online Volltext: dx.doi.org/
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PrefaceIn: High Pressure Chemistry: Synthetic, Mechanistic, and Supercritical Applications / Eldik, Rudi van; Klärner, Frank-Gerrit (Hrsg.) (2008) S. i - xviISBN: 9783527612628; 3527304045; 9783527304042Online Volltext: dx.doi.org/
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Molecular Tweezers and Clips that Modify Protein FunctionIn: Supramolecular Protein Chemistry: Assembly, Architecture and Application / Crowley, Peter B. (Hrsg.) 2021, S. 161 - 198ISBN: 978-1-78801-754-1; 978-1-78801-979-8; 978-1-78801-980-4 ISSN: 2041-7144; 1368-8642Online Volltext: dx.doi.org/
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Using molecular tweezers to remodel abnormal protein self-assembly and inhibit the toxicity of amyloidogenic proteinsIn: Peptide Self-Assembly: Methods and Protocols / Nilsson, Bradley L.; Doran, Todd M. (Hrsg.) 2018, S. 369 - 386ISBN: 978-1-4939-7809-0; 978-1-4939-7811-3Online Volltext: dx.doi.org/
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Molekulare Pinzetten und Klammernals: synthetische Rezeptoren : Molekulare Erkennung, Dynamik, Enzym-Mimetika
Die kleine Form, 14. Juli 2004, Essen,(2004) (Die kleine Form 2004)