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Prof. em Dr. rer. nat. Frank-Gerrit Klärner

Fakultät für Chemie

Raum
S07 S00 C21
Telefon
+49(0)201/183-2087
Telefax
+49(0)201/183-4252
E-Mail
frank.klaerner@uni-essen.de
Webseite
http://www.orgchem.uni-essen.de/ak-klaerner/ak_klaerner.htm

Funktionen

  • Universitätsprofessor/in em./i.R., Organische Chemie

Aktuelle Veranstaltungen

Keine aktuellen Veranstaltungen.

Vergangene Veranstaltungen (max. 10)

Keine vergangenen Veranstaltungen.

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Lantz, Carter; Lopez, Jaybree; Goring, Andrew K.; Zenaidee, Muhammad A.; Biggs, Karl; Whitelegge, Julian P.; Ogorzalek Loo, Rachel R.; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal; Loo, Joseph A.
    Characterization of Molecular Tweezer Binding on α-Synuclein with Native Top-Down Mass Spectrometry and Ion Mobility-Mass Spectrometry Reveals a Mechanism for Aggregation Inhibition
    In: Journal of the American Society for Mass Spectrometry (JASMS) Jg. 34 (2023) Nr. 12, S. 2739 - 2747
    Online Volltext: dx.doi.org/
  • Shahpasand-Kroner, Hedieh; Siddique, Ibrar; Malik, Ravinder; Linares, Gabriel R.; Ivanova, Magdalena I.; Ichida, Justin; Weil, Tatjana; Müunch, Jan; Sanchez-Garcia, Elsa; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal; Münch, Jan
    Molecular Tweezers : Supramolecular Hosts with Broad-Spectrum Biological Applications
    In: Pharmacological Reviews Jg. 75 (2023) Nr. 2, S. 263 - 308
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Weil, Tatjana; Kirupakaran, Abbna; Le, My-Hue; Rebmann, Philipp; Mieres-Perez, Joel; Issmail, Leila; Conzelmann, Carina; Müller, Janis A.; Rauch, Lena; Gilg, Andrea; Wettstein, Lukas; Groß, Rüdiger; Read, Clarissa; Bergner, Tim; Pålsson, Sandra Axberg; Uhlig, Nadja; Eberlein, Valentina; Wöll, Heike; Klärner, Frank-Gerrit; Stenger, Steffen; Kümmerer, Beate M.; Streeck, Hendrik; Fois, Giorgio; Frick, Manfred; Braubach, Peter; Spetz, Anna-Lena; Grunwald, Thomas; Shorter, James; Sanchez-Garcia, Elsa; Schrader, Thomas; Münch, Jan
    Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses
    In: JACS Au Jg. 2 (2022) Nr. 9, S. 2187 - 2202
    Online Volltext: dx.doi.org/ (Open Access)
  • Di, Jing; Siddique, Ibrar; Li, Zizheng; Malki, Ghattas; Hornung, Simon; Dutta, Suman; Hurst, Ian; Ishaaya, Ella; Wang, Austin; Tu, Sally; Boghos, Ani; Ericsson, Ida; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal
    Correction to : The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice
    In: Alzheimer's Research & Therapy Jg. 13 (2021) Nr. 1, S. 88
    Online Volltext: dx.doi.org/ (Open Access)
  • Malishev, Ravit; Salinas, Nir; Gibson, James; Eden, Angela Bailey; Mieres-Perez, Joel; Ruiz-Blanco, Yasser B.; Malka, Orit; Kolusheva, Sofiya; Klärner, Frank-Gerrit; Schrader, Thomas; Sánchez-García, Elsa; Wang, Chunyu; Landau, Meytal; Bitan, Gal; Jelinek, Raz
    Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers
    In: Cell Chemical Biology Jg. 28 (2021) Nr. 9, S. 1310 - 1320.e5
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Li, Zizheng; Siddique, Ibrar; Hadrovic, Inesa; Kirupakaran, Abbna; Li, Jiwen; Zhang, Ye; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal
    Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
    In: Communications Biology Jg. 4 (2021) Nr. 1, 1076
    Online Volltext: dx.doi.org/ (Open Access)
  • Di, Jing; Siddique, Ibrar; Li, Zizheng; Malki, Ghattas; Hornung, Simon; Dutta, Suman; Hurst, Ian; Ishaaya, Ella; Wang, Austin; Tu, Sally; Boghos, Ani; Ericsson, Ida; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal
    The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice
    In: Alzheimer's Research & Therapy Jg. 13 (2021) Nr. 1, S. 6
    Online Volltext: dx.doi.org/ (Open Access)
  • Bengoa-Vergniory, Nora; Faggiani, Emilie; Ramos-Gonzalez, Paula; Kirkiz, Ecem; Connor-Robson, Natalie; Brown, Liam V.; Siddique, Ibrar; Li, Zizheng; Vingill, Siv; Cioroch, Milena; Cavaliere, Fabio; Threlfell, Sarah; Roberts, Bradley; Schrader, Thomas; Klärner, Frank-Gerrit; Cragg, Stephanie; Dehay, Benjamin; Bitan, Gal; Matute, Carlos; Bezard, Erwan; Wade-Martins, Richard
    CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease
    In: Nature Communications Jg. 11 (2020) Nr. 1, S. 4885
    Online Volltext: dx.doi.org/ (Open Access)
  • Prabodh, Amrutha; Bauer, Daniel; Kubik, Stefan; Rebmann, Philipp; Klärner, Frank-Gerrit; Schrader, Thomas; Delarue Bizzini, Lorenzo; Mayor, Marcel; Biedermann, Frank
    Chirality sensing of terpenes, steroids, amino acids, peptides and drugs with acyclic cucurbit[: N] urils and molecular tweezers
    In: Chemical Communications: ChemComm Jg. 56 (2020) Nr. 34, S. 4652 - 4655
    Online Volltext: dx.doi.org/ (Open Access)
  • Mason, Ashley J.; Hurst, Ian; Malik, Ravinder; Siddique, Ibrar; Solomonov, Inna; Sagi, Irit; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal
    Different Inhibitors of Aβ42-Induced Toxicity Have Distinct Metal-Ion Dependency
    In: ACS Chemical Neuroscience Jg. 11 (2020) Nr. 15, S. 2243 - 2255
    Online Volltext: dx.doi.org/ (Open Access)
  • Weil, Tatjana; Groß, Rüdiger; Röcker, Annika; Bravo-Rodriguez, Kenny; Heid, Christian; Sowislok, Andrea; Le, My-Hue; Erwin, Nelli; Dwivedi, Mridula; Bart, Stephen M.; Bates, Paul; Wettstein, Lukas; Müller, Janis A.; Harms, Mirja; Sparrer, Konstantin; Ruiz-Blanco, Yasser B.; Stürzel, Christina M.; von Einem, Jens; Lippold, Sina; Read, Clarissa; Walther, Paul; Hebel, Marco; Kreppel, Florian; Klärner, Frank-Gerrit; Bitan, Gal; Ehrmann, Michael; Weil, Tanja; Winter, Roland; Schrader, Thomas; Shorter, James; Sánchez-García, Elsa; Münch, Jan
    Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers
    In: Journal of the American Chemical Society: JACS Jg. 142 (2020) Nr. 40, S. 17024 - 17038
    Online Volltext: dx.doi.org/ (Open Access)
  • Monaco, Antonio; Maffia, Veronica; Sorrentino, Nicolina Cristina; Sambri, Irene; Ezhova, Yulia; Giuliano, Teresa; Cacace, Vincenzo; Nusco, Edoardo; De Risi, Maria; De Leonibus, Elvira; Schrader, Thomas; Klärner, Frank-Gerrit; Bitan, Gal; Fraldi, Alessandro
    The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease
    In: Molecular Therapy Jg. 28 (2020) Nr. 4, S. 1167 - 1176
    Online Volltext: dx.doi.org/ (Open Access)
  • Despres, Clément; Di, Jing; Cantrelle, François-Xavier; Li, Zizheng; Huvent, Isabelle; Chambraud, Béatrice; Zhao, Jing; Chen, Jianle; Chen, Shiguo; Lippens, Guy; Zhang, Fuming; Linhardt, Robert; Wang, Chunyu; Klärner, Frank-Gerrit; Schrader, Thomas; Landrieu, Isabelle; Bitan, Gal; Smet-Nocca, Caroline
    Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors
    In: ACS Chemical Biology Jg. 14 (2019) Nr. 6, S. 1363 - 1379
    Online Volltext: dx.doi.org/ (Open Access)
  • Hadrovic, Inesa; Rebmann, Philipp; Klärner, Frank-Gerrit; Bitan, Gal; Schrader, Thomas
    Molecular lysine tweezers counteract aberrant protein aggregation
    In: Frontiers in Chemistry Jg. 7 (2019) 657
    Online Volltext: dx.doi.org/ (Open Access)
  • Nshanian, Michael; Lantz, Carter; Wongkongkathep, Piriya; Schrader, Thomas; Klärner, Frank-Gerrit; Blümke, Anika; Despres, Clément; Ehrmann, Michael; Smet-Nocca, Caroline; Bitan, Gal; Loo, Joseph A.
    Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator
    In: Journal of the American Society for Mass Spectrometry (JASMS) Jg. 30 (2019) Nr. 1, S. 16 - 23
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Malik, Ravinder; Meng, Helen; Wongkongkathep, Piriya; Corrales, Christian I.; Sepanj, Niki; Atlasi, Ryan S.; Klärner, Frank-Gerrit; Schrader, Thomas; Spencer, Melissa J.; Loo, Joseph A.; Wiedau, Martina; Bitan, Gal
    The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS
    In: The Journal of Biological Chemistry (JBC) Jg. 294 (2019) Nr. 10, S. 3501 - 3513
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Herrera-Vaquero, Marcos; Bouquio, Danielle; Kallab, Martin; Biggs, Karl; Nair, Gayatri; Ochoa, Jessica; Heras-Garvin, Antonio; Heid, Christian; Hadrovic, Inesa; Poewe, Werner; Wenning, Gregor K.; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal; Stefanova, Nadia
    The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy
    In: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Jg. 1865 (2019) Nr. 11, 165513
    Online Volltext: dx.doi.org/ (Open Access)
  • Heid, Christian; Sowislok, Andrea; Schaller, Torsten; Niemeyer, Felix; Klärner, Frank-Gerrit; Schrader, Thomas
    Molecular tweezers with additional recognition sites
    In: Chemistry - A European Journal Jg. 24 (2018) Nr. 44, S. 11332 - 11343
    Online Volltext: dx.doi.org/
  • Richter, Franziska; Subramaniam, Sudhakar R.; Magen, Iddo; Lee, Patrick; Hayes, Jane; Attar, Aida; Zhu, Chunni; Franich, Nicholas R.; Bove, Nicholas; De La Rosa, Krystal; Kwong, Jacky; Klärner, Frank-Gerrit; Schrader, Thomas; Chesselet, Marie-Françoise; Bitan, Gal
    A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein
    In: Neurotherapeutics Jg. 14 (2017) Nr. 4, S. 1107 - 1119
    Online Volltext: dx.doi.org/
  • Klärner, Frank-Gerrit
    Fritz Vögtle (1939-2017)
    In: Angewandte Chemie International Edition Jg. 56 (2017) Nr. 14, S. 3751 - 3752
    Online Volltext: dx.doi.org/
  • Vöpel, Tobias; Bravo-Rodriguez, Kenny; Mittal, Sumit; Vachharajani, Shivang; Gnutt, David; Sharma, Abhishek; Steinhof, Anne; Fatoba, Oluwaseun; Ellrichmann, Gisa; Nshanian, Michael; Heid, Christian; Loo, Joseph A.; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal; Wanker, Erich E.; Ebbinghaus, Simon; Sánchez-García, Elsa
    Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01
    In: Journal of the American Chemical Society: JACS Jg. 139 (2017) Nr. 16, S. 5640 - 5643
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Xu, Na; Bitan, Gal; Schrader, Thomas; Klärner, Frank-Gerrit; Osinska, Hanna; Robbins, Jeffrey
    Inhibition of Mutant αB Crystallin‐Induced Protein Aggregation by a Molecular Tweezer
    In: Journal of the American Heart Association Jg. 6 (2017) S. e006182
    Online Volltext: dx.doi.org/ (Open Access)
  • Wilch, Constanze; Talbiersky, Peter; Berchner-Pfannschmidt, Utta; Schaller, Torsten; Kirsch, Michael; Klärner, Frank-Gerrit; Schrader, Thomas
    Molecular tweezers inhibit PARP-1 by a new mechanism
    In: European Journal of Organic Chemistry (2017) Nr. 16, S. 2223 - 2229
    Online Volltext: dx.doi.org/
  • Servalli, Marco; Wörle, Michael; Trapp, Nils; Klärner, Frank-Gerrit
    Anthraphane : An Anthracene-Based, Propeller-Shaped D3h-Symmetric Hydrocarbon Cyclophane and Its Layered Single Crystal Structures
    In: The Journal of Organic Chemistry Jg. 81 (2016) Nr. 6, S. 2572 - 2580
    Online Volltext: dx.doi.org/
  • Schrader, Thomas; Bitan, Gal; Klärner, Frank-Gerrit
    Molecular tweezers for lysine and arginine : powerful inhibitors of pathologic protein aggregation
    In: Chemical Communications: ChemComm Jg. 52 (2016) Nr. 76, S. 11318 - 11334
    Online Volltext: dx.doi.org/ (Open Access)
  • Lulla, Aaron; Bronstein, Jeff M.; Sagasti, Alvaro; Schrader, Thomas; Klärner, Frank-Gerrit; Yamashiro, Chase; Stahl, Mark C.; O’Donnell, Kelley; Nguyen, Binh; Barnhill, Lisa; Ivanova, Magdalena I.
    Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos
    In: Environmental Health Perspectives Jg. 124 (2016) Nr. 11, S. 1766 - 1775
    Online Volltext: dx.doi.org/ (Open Access)
  • Fogerson, Stephanie M.; Morgan, Jennifer R.; Bitan, Gal; Schrader, Thomas; Klärner, Frank-Gerrit; Banks, Susan M.L.; Roychaudhuri, Robin; Allen, Scott R.; Busch, David J.; van Brummen, Alexandra J.
    Reducing synuclein accumulation improves neuronal survival after spinal cord injury
    In: Experimental Neurology Jg. 278 (2016) S. 105 - 115
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Lump, Edina; Castellano, Laura M.; Meier, Christoph; Seeliger, Janine; Erwin, Nelli; Sperlich, Benjamin; Stürzel, Christina M.; Usmani, Shariq; Hammond, Rebecca M.; Einem, Jens von; Gerold, Gisa; Kreppel, Florian; Bravo-Rodriguez, Kenny; Pietschmann, Thomas; Holmes, Veronica M.; Palesch, David; Zirafi, Onofrio; Weissman, Drew; Sowislok, Andrea; Wettig, Burkhard; Heid, Christian; Kirchhoff, Frank; Weil, Tanja; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal; Sánchez-García, Elsa; Winter, Roland; Shorter, James; Munch, Jan
    A molecular tweezer antagonizes seminal amyloids and HIV infection
    In: eLife Jg. 4 (2015) Nr. 8, S. e05397
    Online Volltext: dx.doi.org/ (Open Access)
  • Zheng, Xueyun; Bowers, Michael T.; Bitan, Gal; Schrader, Thomas; Klärner, Frank-Gerrit; Liu, Deyu
    Amyloid β-Protein Assembly : The Effect of Molecular Tweezers CLR01 and CLR03
    In: Journal of Physical Chemistry B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical Chemistry Jg. 119 (2015) Nr. 14, S. 4831 - 4841
    Online Volltext: dx.doi.org/ (Open Access)
  • Lopes, Dahabada H. J.; Attar, Aida; Nair, Gayatri; Hayden, Eric Y.; Du, Zhenming; McDaniel, Kirsten; Dutt, Som; Bandmann, Heinz; Bravo-Rodriguez, Kenny; Mittal, Sumit; Klärner, Frank-Gerrit; Wang, Chunyu; Sánchez-García, Elsa; Schrader, Thomas; Bitan, Gal
    Molecular tweezers inhibit islet amyloid polypeptide assembly and toxicity by a new mechanism
    In: ACS Chemical Biology Jg. 10 (2015) Nr. 6, S. 1555 - 1569
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Herzog, Gal; Shmueli, Merav D.; Levy, Limor; Engel, Liat; Gazit, Ehud; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal; Segal, Daniel
    The lys-specific molecular tweezer, CLR01, modulates aggregation of the mutant p53 DNA binding domain and inhibits its toxicity
    In: Biochemistry Jg. 54 (2015) Nr. 24, S. 3729 - 3738
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Malishev, Ravit; Jelinek, Raz; Bitan, Gal; Schrader, Thomas; Klärner, Frank-Gerrit; Levi-Kalisman, Yael; Kolusheva, Sofiya; Nandi, Sukhendu
    Toxicity inhibitors protect lipid membranes from disruption by Aβ42
    In: ACS Chemical Neuroscience Jg. 6 (2015) Nr. 11, S. 1860 - 1869
    Online Volltext: dx.doi.org/
  • Acharya, Srabasti; Lapidus, Lisa J.; Bitan, Gal; Loo, Joseph A.; Schrader, Thomas; Klärner, Frank-Gerrit; Attar, Aida; Ivanova, Magdalena I.; Wongkongkathep, Piriya; Safaie, Brian M.
    Molecular Basis for Preventing α-Synuclein Aggregation by a Molecular Tweezer
    In: The Journal of Biological Chemistry (JBC) Jg. 289 (2014) Nr. 5, S. 10727 - 10737
    Online Volltext: dx.doi.org/
  • Ferreira, Nelson; Pereira-Henriques, Alda; Attar, Aida; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal; Gales, Luís; Saraiva, Maria João; Almeida, Maria Rosário
    Molecular Tweezers Targeting Transthyretin Amyloidosis
    In: Neurotherapeutics Jg. 11 (2014) Nr. 2, S. 450 - 461
    Online Volltext: dx.doi.org/ (Open Access)
  • Attar, Aida; Bitan, Gal; Schrader, Thomas; Klärner, Frank-Gerrit; Coco Chan, Wai-Ting
    Safety and pharmacological characterization of the molecular tweezer CLR01 – a broad-spectrum inhibitor of amyloid proteins’ toxicity
    In: BMC Pharmacology and Toxicology Jg. 15 (2014) S. 23
    Online Volltext: dx.doi.org/ (Open Access)
  • Klärner, Frank-Gerrit; Schrader, Thomas
    Aromatic interactions by molecular tweezers and clips in chemical and biological systems
    In: Accounts of Chemical Research Jg. 46 (2013) Nr. 4, S. 967 - 978
    Online Volltext: dx.doi.org/
  • Gersthagen, Thomas; Hofmann, Johannes; Klärner, Frank-Gerrit; Schmuck, Carsten; Schrader, Thomas
    Ditopic arginine-aspartate binders recognize RGD loops
    In: European Journal of Organic Chemistry (2013) Nr. 6, S. 1080 - 1092
    Online Volltext: dx.doi.org/
  • Dutt, Som; Wilch, Constanze; Gersthagen, Thomas; Wölper, Christoph; Sowislok, Andrea; Klärner, Frank-Gerrit; Schrader, Thomas
    Linker effects on amino acid and peptide recognition by molecular tweezers
    In: European Journal of Organic Chemistry (2013) Nr. 34, S. 7705 - 7714
    Online Volltext: dx.doi.org/
  • Dutt, Som; Schrader, Thomas; Klärner, Frank-Gerrit; Ochsenfeld, Christian; Sánchez-García, Elsa; Hanni, Matti; Bravo-Rodriguez, Kenny; Talbiersky, Peter; Gersthagen, Thomas; Wilch, Constanze
    Molecular Tweezers with Varying Anions : A Comparative Study
    In: The Journal of Organic Chemistry Jg. 78 (2013) Nr. 13, S. 6721 - 6734
    Online Volltext: dx.doi.org/
  • Bier, David; Ottmann, Christian; Schrader, Thomas; Sánchez-García, Elsa; Klärner, Frank-Gerrit; Wilch, Constanze; Dutt, Som; Ramirez-Anguita, Juan Manuel; Bartels, Maria; Bravo-Rodriguez, Kenny; Rose, Rolf
    Molecular tweezers modulate 14-3-3 protein–protein interactions
    In: Nature Chemistry Jg. 5 (2013) Nr. 3, S. 234 - 239
    Online Volltext: dx.doi.org/
  • Zieringer, Maximilian; Casas Cartagena, Marçal; Burakowska, Ewelina; Taktikos, Johannes; Neuthe, Katja; Bandmann, Heinz; Klärner, Frank-Gerrit; Haag, Rainer
    Polyglycerol-tagged molecular clips as receptors in protic solvents
    In: European Journal of Organic Chemistry (2013) Nr. 2, S. 362 - 367
    Online Volltext: dx.doi.org/
  • Li, Ming; Schlüter, Dieter; Sakamoto, Junji; Klärner, Frank-Gerrit
    Synthesis of Shape-Persistent Macrocycles with Three 1,8-Diazaanthracene Units and Their Packing in the Single Crystal
    In: Chemistry - A European Journal Jg. 19 (2013) Nr. 40, S. 13348 - 13354
    Online Volltext: dx.doi.org/
  • Prabhudesai, Shubhangi; Sinha, Sharmistha; Attar, Aida; Kotagiri, Aswani; Fitzmaurice, Arthur G.; Lakshmanan, Ravi; Ivanova, Magdalena I.; Loo, Joseph A.; Klärner, Frank-Gerrit; Schrader, Thomas; Stahl, Mark; Bitan, Gal; Bronstein, Jeff M.
    A Novel "Molecular Tweezer" Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo
    In: Neurotherapeutics Jg. 9 (2012) Nr. 2, S. 464 - 476
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Sinha, Sharmistha; Bitan, Gal; Wang, Chunyu; Schrader, Thomas; Klärner, Frank-Gerrit; Maiti, Panchanan; Du, Zhenming
    Comparison of Three Amyloid Assembly Inhibitors : The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01
    In: ACS Chemical Neuroscience Jg. 3 (2012) Nr. 6, S. 451 - 458
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Bergamini, Giacomo; Molloy, Jennifer K.; Fermi, Andrea; Ceroni, Paola; Klärner, Frank-Gerrit; Hahn, Uwe
    Diazapyrenium cored dendrimers : electron poor guests for a molecular clip host
    In: New Journal of Chemistry Jg. 36 (2012) Nr. 2, S. 354 - 359
    Online Volltext: dx.doi.org/
  • Klärner, Frank-Gerrit; Madenci, Süreyya; Kuchenbrandt, Mireia Campañá; Bläser, Dieter; Boese, Roland; Fukuhara, Gaku; Inoue, Yoshihisa
    Donor/acceptor-substituted chiral molecular clips - Synthesis and host-guest complex formation
    In: European Journal of Organic Chemistry (2012) Nr. 18, S. 3385 - 3395
    Online Volltext: dx.doi.org/
  • Prabhudesai, Shubhangi; Bitan, Gal; Stahl, Mark; Klärner, Frank-Gerrit; Loo, Joseph A.; Ivanova, Magdalena I.; Lakshmanan, Rajeswari; Fitzmaurice, Arthur G.; Schrader, Thomas; Kotagiri, Aswani; Attar, Aida; Sinha, Sharmistha
    Erratum to: A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity In Vitro and In Vivo
    In: Neurotherapeutics Jg. 9 (2012) Nr. 2, S. 486
    Online Volltext: dx.doi.org/
  • Attar, Aida; Bitan, Gal; Grassi, Claudio; Schrader, Thomas; Klärner, Frank-Gerrit; Straudinger, Jeffrey L.; Tan, Miao; Gale, Greg D.; Lichti-Kaiser, Kristin; Hayes, Jane; Liu, Tingyu; Maiti, Panchanan; Riccardi, Elisa; Ripoli, Christian
    Protection of primary neurons and mouse brain from Alzheimer’s pathology by molecular tweezers
    In: Brain: A Journal of Neurology Jg. 135 (2012) Nr. 12, S. 3735 - 3748
    Online Volltext: dx.doi.org/
  • Branchi, Barbara; Klärner, Frank-Gerrit; Vögtle, Fritz; Doddi, Giancarlo; Alvino, Antonello; Ceroni, Paola; Fiandro, Luca; Bergamini, Giacomo
    A molecular clip throws new light on the complexes formed by a family of cyclam-cored dendrimers with Zn(II) ions : Efficient energy transfer in the heteroleptic complexes
    In: Dalton Transactions Jg. 40 (2011) Nr. 6, S. 1356 - 1364
    Online Volltext: dx.doi.org/
  • Altenbach, Hans-Josef; Müllen, Klaus; Klärner, Frank-Gerrit; Brinkler, Udo H.
    Emanuel Vogel (1927-2011)
    In: Nachrichten aus der Chemie Jg. 59 (2011) Nr. 6, S. 655
    Online Volltext: dx.doi.org/
  • Sinha, Sharmistha; Lopes, Dahabada H. J.; Du, Zhenming; Pang, Eric S.; Shanmugam, Akila; Lomakin, Aleksey; Talbiersky, Peter; Tennstaedt, Annette; McDaniel, Kirsten; Bakshi, Reena; Kuo, Pei-Yi; Ehrmann, Michael; Benedek, George B.; Loo, Joseph A.; Klärner, Frank-Gerrit; Schrader, Thomas; Wang, Chunyu; Bitan, Gal
    Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins
    In: Journal of the American Chemical Society: JACS Jg. 133 (2011) Nr. 42, S. 16958 - 16969
    Online Volltext: dx.doi.org/
  • Bastkowski, Frank; Polkowska, Jolanta; Schrader, Thomas; Klärner, Frank-Gerrit
    Non covalent inclusion of nucleosides and nucleotides in water-soluble molecular clips
    In: Heterocycles Jg. 82 (2011) Nr. 2, S. 1549 - 1566
    Online Volltext: dx.doi.org/
  • Klärner, Frank-Gerrit
    [Obituary] William von Eggers Doering
    In: Angewandte Chemie International Edition Jg. 50 (2011) Nr. 13, S. 2885 - 2886
    Online Volltext: dx.doi.org/
  • Branchi, Barbara; Vögtle, Fritz; Klärner, Frank-Gerrit; Balzani, Vincenzo; Ceroni, Paola
    A Light-Harvesting Antenna Resulting from the Self-Assembly of Five Luminescent Components : A Dendrimer, Two Clips, and Two Lanthanide Ions
    In: Chemistry - A European Journal Jg. 16 (2010) Nr. 20, S. 6048 - 6055
    Online Volltext: dx.doi.org/
  • Klärner, Frank-Gerrit; Kirsch, Michael; de Groot, Herbert; Schaller, Torsten; Campana Kuchenbrandt, Mireia; Talbiersky, Peter; Bastkoswki, Frank; Polkowska, Jolanta; Schrader, Thomas
    Effect of molecular clips and tweezers on enzymatic reactions by binding coenzymes and basic amino acids
    In: Pure and Applied Chemistry Jg. 82 (2010) Nr. 4, S. 991 - 999
    Online Volltext: dx.doi.org/
  • Jansen, Georg; Bläser, Dieter; Boese, Roland; Klärner, Frank-Gerrit; Kahlert, Björn
    Intramolecular Electronic Interactions between Nonconjugated Arene and Quinone Chromophores
    In: Journal of the American Chemical Society: JACS Jg. 132 (2010) Nr. 25, S. 8581 - 8592
    Online Volltext: dx.doi.org/
  • Branchi, Barbara; Klärner, Frank-Gerrit; Vögtle, Fritz; Ceroni, Paola; Fiandro, Luca; Bergamini, Giacomo
    Metal ion driven formation of a light-harvesting antenna investigated by sensitized luminescence and fluorescence anisotropy
    In: Chemical Communications: ChemComm Jg. 46 (2010) Nr. 20, S. 3571 - 3573
    Online Volltext: dx.doi.org/
  • Schaller, Torsten; Buechele, Uta P.; Klärner, Frank-Gerrit; Blaeser, Dieter; Boese, Roland; Brown, Steven P.; Spiess, Hans Wolfgang; Koziol, Felix; Kussmann, Joerg; Ochsenfeld, Christian
    Structure of Molecular Tweezer Complexes in the Solid State : NMR Experiments, X-ray Investigations, and Quantum Chemical Calculations.
    In: Journal of the American Chemical Society: JACS Jg. 129 (2007) Nr. 5, S. 1293 - 1303
    Online Volltext: dx.doi.org/
  • Lobert, Matthias; Bandmann, Heinz; Burkert, Ulrich; Buchele, Uta P.; Podsadlowski, Viola; Klärner, Frank-Gerrit
    Dynamics in Host–Guest Complexes of Molecular Tweezers and Clips
    In: Chemistry - A European Journal Jg. 12 (2006) Nr. 6, S. 1629 - 1641
    Online Volltext: dx.doi.org/
  • Klärner, Frank-Gerrit; Kahlert, Bjoern; Nellesen, Anke; Zienau, Jan; Ochsenfeld, Christian; Schrader, Thomas
    Molecular Tweezer and Clip in Aqueous Solution: Unexpected Self-Assembly, Powerful Host-Guest Complex Formation, Quantum Chemical 1H NMR Shift Calculation.
    In: Journal of the American Chemical Society: JACS Jg. 128 (2006) Nr. 14, S. 4831 - 4841
    Online Volltext: dx.doi.org/
  • Fokkens, Michael; Klärner, Frank-Gerrit; Schrader, Thomas
    Nucleoside sensing.
    In: Sensors Jg. 6 (2006) Nr. 8, S. 860 - 873
    Online Volltext: dx.doi.org/ (Open Access)
  • Fokkens, Michael; Schrader, Thomas; Klärner, Frank-Gerrit
    A Molecular Tweezer for Lysine and Arginine
    In: Journal of the American Chemical Society: JACS Jg. 127 (2005) Nr. 41, S. 14415 - 14421
    Online Volltext: dx.doi.org/
  • Schrader, Thomas; Fokkens, Michael; Klärner, Frank-Gerrit; Polkowska, Jolanta; Bastkowski, Frank
    Inclusion of Thiamine Diphosphate and S-Adenosylmethionine at Their Chemically Active Sites
    In: The Journal of Organic Chemistry Jg. 70 (2005) Nr. 25, S. 10227 - 10237
    Online Volltext: dx.doi.org/
  • Fokkens, Michael; Jasper, Christian; Schrader, Thomas; Koziol, Felix; Ochsenfeld, Christian; Polkowska, Jolanta; Lobert, Matthias; Kahlert, Bjoern; Klärner, Frank-Gerrit
    Selective Complexation of N-Alkylpyridinium Salts : Binding of NAD+ in Water
    In: Chemistry - A European Journal Jg. 11 (2005) Nr. 2, S. 477 - 494
    Online Volltext: dx.doi.org/
  • Klärner, Frank-Gerrit; Polkowska, Jolanta; Panitzky, Jens; Seelbach, Uta P.; Burkert, Ulrich; Kamieth, Markus; Baumann, Michael; Wigger, Arne E.; Boese, Roland; Blaeser, Dieter
    Effect of Substituents on the Complexation of Aromatic and Quinoid Substrates with Molecular Tweezers and Clips
    In: European Journal of Organic Chemistry (2004) Nr. 7, S. 1405 - 1423
    Online Volltext: dx.doi.org/
  • Klärner, Frank-Gerrit; Lobert, Matthias; Naatz, Ulf; Bandmann, Heinz; Boese, Roland
    Synthesis and Supramolecular Properties of Trimethylene-Bridged Clips
    In: Chemistry - A European Journal Jg. 9 (2003) Nr. 20, S. 5036 - 5047
    Online Volltext: dx.doi.org/
  • Jasper, Christian; Schrader, Thomas; Panitzky, Jens; Klärner, Frank-Gerrit
    Selective Complexation of N-Alkylpyridinium Salts : Recognition of NAD+ in Water
    In: Angewandte Chemie International Edition Jg. 41 (2002) Nr. 8, S. 1355 - 1358
    Online Volltext: dx.doi.org/
  • Klärner, Frank-Gerrit; Burkert, Ulrich; Kamieth, Markus; Boese, Roland
    Molecular tweezers as synthetic receptors: molecular recognition of neutral and cationic aromatic substrates : A comparison between the supramolecular structures in crystal and in solution
    In: Journal of Physical Organic Chemistry Jg. 13 (2000) Nr. 10, S. 604 - 611
    Online Volltext: dx.doi.org/
  • Klärner, Frank-Gerrit; Burkert, Ulrich; Kamieth, Markus; Boese, Roland; Benet-Buchholz, Jordi
    Molecular Tweezers as Synthetic Receptors : Molecular Recognition of Electron-Deficient Aromatic and Aliphatic Substrates
    In: Chemistry - A European Journal Jg. 5 (1999) Nr. 6, S. 1700 - 1707
    Online Volltext: dx.doi.org/
  • Klärner, Frank-Gerrit; Ehrhardt, Ralf; Bandmann, Heinz; Boese, Roland; Blaser, Dieter; Houk, K.n.; Beno, Brett R.
    Pressure-Induced Cycloadditions of Dicyanoacetylene to Strained Arenes : The Formation of Cyclooctatetraene, 9,10-Dihydronaphthalene, and Azulene Derivatives; A Degenerate [1,5] Sigmatropic Shift—Comparison between Theory and Experiment
    In: Chemistry - A European Journal Jg. 5 (1999) Nr. 7, S. 2119 - 2132
    Online Volltext: dx.doi.org/
  • Haumann, Thomas; Benet-Buchholz, Jordi; Klärner, Frank-Gerrit; Boese, Roland
    Structural Aspects of Cyclopropyl Homoconjugation : Experimental Studies and Ab Initio Calculations
    In: Liebigs Annalen/Recueil (1997) Nr. 7, S. 1429 - 1435
    Online Volltext: dx.doi.org/
  • Benkhoff, Johannes; Boese, Roland; Klärner, Frank-Gerrit
    Synthesis of sterically rigid macrocycles by the use of pressure-induced repetitive Diels-Alder reactions
    In: Liebigs Annalen/Recueil (1997) Nr. 3, S. 501 - 516
    Online Volltext: dx.doi.org/
  • Klärner, Frank-Gerrit; Benkhoff, Johannes; Boese, Roland; Burkett, Ulrich; Kamieth, Markus; Naatz, Ulf
    Molecular Tweezers as Synthetic Receptors in Host—Guest Chemistry : Inclusion of Cyclohexane and Self-Assembly of Aliphatic Side Chains
    In: Angewandte Chemie International Edition Jg. 35 (1996) Nr. 10, S. 1130 - 1133
    Online Volltext: dx.doi.org/

    • Vorworte / Nachworte

  • van Eldik, Rudi; Klärner, Frank-Gerrit
    Preface
    In: High Pressure Chemistry: Synthetic, Mechanistic, and Supercritical Applications / Eldik, Rudi van; Klärner, Frank-Gerrit (Hrsg.) (2008) S. i - xvi
    Online Volltext: dx.doi.org/

    • Beiträge in Sammelwerken und Tagungsbänden

  • Alavijeh, Nahid S.; Kirupakaran, Abbna; Klärner, Frank-Gerrit; Schrader, Thomas
    Molecular Tweezers and Clips that Modify Protein Function
    In: Supramolecular Protein Chemistry: Assembly, Architecture and Application / Crowley, Peter B. (Hrsg.) 2021, S. 161 - 198
    Online Volltext: dx.doi.org/
  • Malik, Ravinder; Di, Jing; Nair, Gayatri; Attar, Aida; Taylor, Karen; Teng, Edmond; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal
    Using molecular tweezers to remodel abnormal protein self-assembly and inhibit the toxicity of amyloidogenic proteins
    In: Peptide Self-Assembly: Methods and Protocols / Nilsson, Bradley L.; Doran, Todd M. (Hrsg.) 2018, S. 369 - 386
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)

    • Vorträge

  • Klärner, Frank-Gerrit;
    Molekulare Pinzetten und Klammernals: synthetische Rezeptoren : Molekulare Erkennung, Dynamik, Enzym-Mimetika
    Die kleine Form, 14. Juli 2004, Essen,
    In: Die kleine Form 2004 (2004)
    Online Volltext