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Universitätsprofessor/in, Institut für Anatomie
Aktuelle Veranstaltungen
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WiSe 2025
- Seminar Anatomie (Neuroanatomie) (3.FS)
- Vorlesung Makroskopische Anatomie (1. FS) (Osteologie, passiver Bewegungsapparat, Propädeutik)
- Begleitvorlesung zum Seminar Anatomie (Neuroanatomie, 3. FS)
- Wahlfach: Entwicklungsbiologie des Nervensystems (3.FS)
- Modern Biomedicine/Beispiele biologischer Forschung (Teil 1)
- Retinopathien und Mechanismen der retinalen Proliferations- und Apoptosekontrolle
- Anleitung zum wissenschaftlichen Arbeiten
- Anatomie 1: Vorlesung Makroskopische Anatomie (Osteologie, passiver Bewegungsapparat) für Medizintechniker
Vergangene Veranstaltungen (max. 10)
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SoSe 2025
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WiSe 2024
- Begleitvorlesung zum Seminar Anatomie (Neuroanatomie, 3. FS)
- Wahlfach: Entwicklungsbiologie des Nervensystems (3.FS)
- Vorlesung Makroskopische Anatomie (1. FS) (Osteologie, passiver Bewegungsapparat, Propädeutik)
- Seminar Anatomie (Neuroanatomie) (3.FS)
- Retinopathien und Mechanismen der retinalen Proliferations- und Apoptosekontrolle
- Anleitung zum wissenschaftlichen Arbeiten
- Anatomie 1: Vorlesung Makroskopische Anatomie (Osteologie, passiver Bewegungsapparat) für Medizintechniker
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Tumor cells that resist neutrophil anticancer cytotoxicity acquire a prometastatic and innate immune escape phenotypeIn: Cellular & Molecular Immunology, Jg. 22, 2025, Nr. 5, S. 527 – 540DOI (Open Access)
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Fatty acid conjugated EPI-X4 derivatives with increased activity and in vivo stabilityIn: Journal of Controlled Release, Jg. 373, 2024, S. 583 – 598DOI (Open Access)
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Gastric Inhibitory Polypeptide Receptor (GIPR) Overexpression Reduces the Tumorigenic Potential of Retinoblastoma CellsIn: Cancers, Jg. 16, 2024, Nr. 9, 1656DOI, Online Volltext (Open Access)
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In vitro model of retinoblastoma derived tumor and stromal cells for tumor microenvironment (TME) studiesIn: Cell Death and Disease, Jg. 15, 2024, Nr. 12, 905DOI (Open Access)
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New retinoblastoma (RB) drug delivery approaches : anti-tumor effect of atrial natriuretic peptide (ANP)-conjugated hyaluronic-acid-coated gold nanoparticles for intraocular treatment of chemoresistant RBIn: Molecular Oncology, Jg. 18, 2024, Nr. 4, S. 832 – 849DOI, Online Volltext (Open Access)
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Role of Protein Tyrosine Phosphatase Receptor Type E (PTPRE) in Chemoresistant RetinoblastomaIn: International Journal of Molecular Sciences (IJMS), Jg. 25, 2024, Nr. 8, 4572DOI, Online Volltext (Open Access)
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α-Ketoglutarate supplementation and NAD+ modulation enhance metabolic rewiring and radiosensitization in SLC25A1 inhibited cancer cellsIn: Cell Death Discovery, Jg. 10, 2024, Nr. 1, 27DOI, Online Volltext (Open Access)
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Evaluation of the Effect of Photodynamic Therapy on CAM-Grown SarcomasIn: Bioengineering, Jg. 10, 2023, Nr. 4, 464DOI, Online Volltext (Open Access)
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Novel Function of Cancer Stem Cell Marker ALDH1A3 in Glioblastoma : Pro-Angiogenesis through Paracrine PAI-1 and IL-8In: Cancers, Jg. 15, 2023, Nr. 17, 4422DOI (Open Access)
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Trefoil Family Factor Peptide 1 : A New Biomarker in Liquid Biopsies of Retinoblastoma under TherapyIn: Cancers, Jg. 15, 2023, Nr. 19, 4828DOI, Online Volltext (Open Access)
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Tumor Suppressor Role of INPP4B in Chemoresistant RetinoblastomaIn: Journal of Oncology, 2023, 2270097DOI, Online Volltext (Open Access)
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5-ALA-mediated fluorescence of musculoskeletal tumors in a chick chorio-allantoic membrane model : Preclinical in vivo qualification analysis as a fluorescence-guided surgery agent in Orthopedic OncologyIn: Journal of Orthopaedic Surgery and Research, Jg. 17, 2022, Nr. 1, 34DOI, Online Volltext (Open Access)
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ADAM10 and ADAM17 : Novel Players in Retinoblastoma CarcinogenesisIn: International Journal of Molecular Sciences (IJMS), Jg. 23, 2022, Nr. 20, 12621DOI, Online Volltext (Open Access)
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Retinoblastoma Cell Growth 'In Vitro' and Tumor Formation 'In Ovo' : Influence of Different Culture ConditionsIn: Methods and Protocols, Jg. 5, 2022, Nr. 2, 21DOI, Online Volltext (Open Access)
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Role of L1CAM in retinoblastoma tumorigenesis : identification of novel therapeutic targetsIn: Molecular Oncology, Jg. 16, 2022, Nr. 4, S. 957 – 981DOI, Online Volltext (Open Access)
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TFF1 in Aqueous Humor : A Potential New Biomarker for RetinoblastomaIn: Cancers, Jg. 14, 2022, Nr. 3, 677DOI, Online Volltext (Open Access)
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Impact of RARα and miR-138 on retinoblastoma etoposide resistanceIn: Tumor Biology, Jg. 43, 2021, Nr. 1, S. 11 – 26DOI, Online Volltext (Open Access)
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Hyaluronic acid coating of gold nanoparticles for intraocular drug delivery : Evaluation of the surface properties and effect on their distributionIn: Experimental Eye Research, Jg. 198, 2020, 108151DOI (Open Access)
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Implementation of the chick chorioallantoic membrane (CAM) model in radiation biology and experimental radiation oncology researchIn: Cancers, Jg. 11, 2019, Nr. 10, S. 1499DOI, Online Volltext (Open Access)
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p53, miR-34a and EMP1 : Newly Identified Targets of TFF3 Signaling in Y79 Retinoblastoma CellsIn: International Journal of Molecular Sciences (IJMS), Jg. 20, 2019, Nr. 17, S. 4129DOI, Online Volltext (Open Access)
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Characterization of etoposide- and cisplatin-chemoresistant retinoblastoma cell linesIn: Oncology Reports, Jg. 39, 2018, Nr. 1, S. 160 – 172DOI (Open Access)
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Trefoil factor family 1 expression correlates with clinical outcome in petients withr retinoblastomaIn: Retina, Jg. 38, 2018, Nr. 12, S. 2422 – 2428
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Reduction of the tumorigenic potential of human retinoblastoma cell lines by TFF1 overexpression involves p53/caspase signaling and miR-18a regulationIn: International Journal of Cancer, Jg. 141, 2017, Nr. 3, S. 549 – 560
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Forced Trefoil Factor Family Peptide 3 (TFF3) Expression Reduces Growth, Viability, and Tumorigenicity of Human Retinoblastoma Cell LinesIn: PLoS ONE, Jg. 11, 2016, Nr. 9, 0163025DOI (Open Access)
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Additive effects of retinoic acid (RA) and bone morphogenetic protein 4 (BMP-4) apoptosis signaling in retinoblastoma cell linesIn: PLoS ONE, Jg. 10, 2015, Nr. 7, e0131467DOI (Open Access)
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Re-characterization of established human retinoblastoma cell linesIn: Histochemistry and Cell Biology, Jg. 143, 2015, Nr. 3, S. 325 – 338
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Trefoil factor family peptides : Friends or foes?In: Biomolecular Concepts, Jg. 6, 2015, Nr. 5-6, S. 343 – 359
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Epigenetic control of trefoil factor family (TFF) peptide expression in human retinoblastoma cell linesIn: Cellular Physiology and Biochemistry, Jg. 34, 2014, Nr. 3, S. 1001 – 1014DOI (Open Access)
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High trefoil factor 1 (TFF1) expression in human retinoblastoma cells correlates with low growth kinetics, increased cyclin-dependent kinase (CDK) inhibitor levels and a selective down-regulation of CDK6In: Histochemistry and Cell Biology, Jg. 139, 2013, Nr. 2, S. 323 – 338
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Loss at chromosome arm 16q in retinoblastoma : confirmation of the association with diffuse vitreous seeding and refinement of the recurrently deleted regionIn: Genes, Chromosomes and Cancer, Jg. 50, 2011, Nr. 5, S. 327 – 337
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Trefoil factor family peptide 2 acts pro-proliferative and pro-apoptotic in the murine retina.In: Histochemistry and Cell Biology, Jg. 135, 2011, Nr. 5, S. 461 – 473
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Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cellsIn: International Journal of Biological Sciences, Jg. 6, 2010, Nr. 7, S. 700 – 715DOI (Open Access)
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Chick ex ovo culture and ex ovo CAM assay : How it really worksIn: JoVE, 2010, Nr. 33, S. e1620DOI, Online Volltext (Open Access)
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In vivo-like Organotypic Murine Retinal Wholemount CultureIn: JoVE, 2010, Nr. 35, S. e1634DOI, Online Volltext (Open Access)
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The anemia of the newborn induces erythropoietin expression in the developing mouse retinaIn: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Jg. 299, 2010, Nr. 1, S. R111 – R118
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Recruitment and maintenance of tendon progenitors by TGFβ signaling are essential for tendon formationIn: Development / Company of Biologists, Jg. 136, 2009, Nr. 8, S. 1351 – 1361DOI, Online Volltext (Open Access)
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Transforming growth factor beta mediates apoptosis in the ganglion cell layer during all programmed cell death periods of the developing murine retinaIn: Neuroscience Research, Jg. 56, 2006, Nr. 2, S. 193 – 203
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Transforming growth factor β is required for differentiation of mouse mesencephalic progenitors into dopaminergic neurons in vitro and in vivo : Ectopic induction in dorsal mesencephalonIn: Stem Cells, Jg. 24, 2006, Nr. 9, S. 2120 – 2129DOI (Open Access)
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Transforming growth factor-β and bone morphogenetic proteins: Cooperative players in chick and murine programmed retinal cell deathIn: The Journal of Comparative Neurology, Jg. 495, 2006, Nr. 3, S. 263 – 278
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Balance of pro-apoptotic transforming growth factor-β and anti-apoptotic insulin effects in the control of cell death in the postnatal mouse retinaIn: European Journal of Neuroscience, Jg. 22, 2005, Nr. 1, S. 28 – 38
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Transforming growth factor-β (TGF-β) and programmed cell death in the vertebrate retinaIn: International Review of Cytology, Jg. 245, 2005, S. 17 – 43
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Isoform-specific role of transforming growth factor-β2 in the regulation of proliferation and differentiation of murine adrenal chromaffin cells in vivoIn: Journal of Neuroscience Research, Jg. 78, 2004, Nr. 4, S. 493 – 498
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Immunohistochemical evaluation of matrix molecules associated with wound healing following treatment with an enamel matrix protein derivative in humansIn: Clinical Oral Investigations, Jg. 7, 2003, Nr. 3, S. 167 – 174
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Reduced programmed cell death in the retina and defects in lens and cornea of Tgfβ2 –/– Tgfβ3 –/– double-deficient miceIn: Cell and Tissue Research, Jg. 313, 2003, Nr. 1, S. 1 – 10
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Transforming Growth Factor-βs Are Essential for the Development of Midbrain Dopaminergic NeuronsIn VitroandIn VivoIn: The Journal of Neuroscience, Jg. 23, 2003, Nr. 12, S. 5178 – 5186DOI (Open Access)
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Transforming growth factor beta mediated programmed cell death in tissue regeneration of the murine intestinal mucosa.In: Annals of Anatomy, Jg. 185, 2003, Nr. 4, S. 299 – 300
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Transforming growth factor-β and tumor necrosis factor-α cooperate to induce apoptosis in the oligodendroglial cell line OLI-neuIn: Journal of Neuroscience Research, Jg. 73, 2003, Nr. 3, S. 324 – 333
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Immunohistochemical evaluation of matrix molecules associated with wound healing following regenerative periodontal treatment in monkeysIn: Clinical Oral Investigations, Jg. 6, 2002, Nr. 3, S. 175 – 182
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TGF-β is required for programmed cell death in interdigital webs of the developing mouse limbIn: Mechanisms of Development, Jg. 113, 2002, Nr. 2, S. 111 – 120DOI (Open Access)
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Tgfβ2⁻/⁻Tgfβ3⁻/⁻ double knockout mice display severe midline fusion defects and early embryonic lethalityIn: Anatomy and Embryology, Jg. 206, 2002, Nr. 1-2, S. 73 – 83
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The role of transforming growth factor beta-2, beta-3 in mediating apoptosis in the murine intestinal mucosaIn: Gastroenterology, Jg. 122, 2002, Nr. 5, S. 1364 – 1375
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Transforming growth factor-beta 2 heterozygous mutant mice exhibit Cowper's gland hyperplasia and cystic dilations of the gland ducts (Cowper's syringoceles)In: Journal of Anatomy, Jg. 201, 2002, Nr. 2, S. 173 – 183DOI, Online Volltext (Open Access)
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Transforming growth factor-β induced cell death in the developing chick retina is mediated via activation of c-jun N-terminal kinase and downregulation of the anti-apoptotic protein Bcl-XLIn: Neuroscience Letters, Jg. 330, 2002, Nr. 3, S. 239 – 242
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TGF-beta modulates programmed cell death in the retina of the developing chick embryo.In: Development, Jg. 128, 2001, Nr. 11, S. 1933 – 1942
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Embryonic and larval development in the caecilian Ichthyophis kohtaoensis (Amphibia, gymnophiona) : a staging tableIn: Journal of morphology, Jg. 243, 2000, Nr. 1, S. 3 – 34
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Reduction of endogenous transforming growth factors β prevents ontogenetic neuron deathIn: Nature Neuroscience, Jg. 3, 2000, Nr. 11, S. 1085 – 1090
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Targeted mutations of transforming growth factor-β genes reveal important roles in mouse development and adult homeostasisIn: EJB: the FEBS Journal, Jg. 267, 2000, Nr. 24, S. 6982 – 6988
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Serotonergic neurons and processes in the adult and developing retina of Ichthyophis kohtaoensis (Amphibia; Gymnophiona)In: Anatomy and Embryology, Jg. 199, 1999, Nr. 1, S. 35 – 43
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A double-label analysis demonstrating the partial coexistence of tyrosine hydroxylase and GABA in retinal neurons of Ichthyophis kohtaoensis (Amphibia; Gymnophiona)In: Cell and Tissue Research, Jg. 294, 1998, Nr. 2, S. 387 – 390
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Colocalization of serotonin and GABA in retinal neurons of Ichthyophis kohtaoensis (amphibia; Gymnophiona)In: Anatomy and embryology, Jg. 197, 1998, Nr. 1, S. 69 – 75
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Development and organization of the retinal dopaminergic system of Ichthyophis kohtaoensis (Amphibia; Gymnophiona)In: Cell and Tissue Research, Jg. 289, 1997, Nr. 2, S. 265 – 274
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Correlation of neurotrophin expression and survival-promoting capacities with different programmed cell death periods in the developing murine retinaIn: Neuroanatomy Research Advances / Callaghan, Brandon R.; Flynn, Cian E. (Hrsg.): Nova Science Publishers, 2010, S. 93 – 120
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How to deal with (cross)-resistant retinoblastoma cells
114. Jahrestagung / 33. Arbeitstagung der Anatomischen Gesellschaft, Würzburg, 25.-27.09.2019,Würzburg, 2019