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Institut für Virologie der Medizinischen Fakultät
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Virchowstr. 179 / Robert-Koch-Haus
45147 Essen
45147 Essen
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Stellv. Direktor/in, Institut für Virologie
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Universitätsprofessor/in, Institut für Virologie
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Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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A healthcare-associated outbreak of hepatitis C virus infections attributable to tampering injectable anaesthetic opioids, South Germany, 2017–2018In: Frontiers in Public Health, Jg. 13, 2025, 1589562DOI (Open Access)
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HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replicationIn: Journal of Hepatology, Jg. 82, 2025, Nr. 5, S. 805 – 815DOI (Open Access)
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SARS-CoV-2-Infection in People Addicted to Illegal Drugs : Is There a Protective Effect of Opioid Maintenance Treatment?In: Pharmacopsychiatry, Jg. 57, 2024, Nr. 5, S. 255 – 260
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Efficient Inactivation of Monkeypox Virus by World Health Organization : Recommended Hand Rub Formulations and AlcoholsIn: Emerging Infectious Diseases (EID), Jg. 29, 2023, Nr. 1, S. 189 – 192DOI (Open Access)
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Impaired humoral immunity to BQ.1.1 in convalescent and vaccinated patientsIn: Nature Communications, Jg. 14, 2023, Nr. 1, 2835DOI (Open Access)
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Sequence diversity of hepatitis D virus in MongoliaIn: Frontiers in Medicine, Jg. 10, 2023, 1108543DOI (Open Access)
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Stability and Inactivation of Monkeypox Virus on Inanimate SurfacesIn: The Journal of Infectious Diseases (JID), Jg. 228, 2023, Nr. 9, S. 1227 – 1230DOI (Open Access)
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HAMdetector : A Bayesian regression model that integrates information to detect HLA-associated mutationsIn: Bioinformatics, Jg. 38, 2022, Nr. 9, S. 2428 – 2436DOI (Open Access)
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Immune escape pathways from the HBV core₁₈₋₂₇ CD8 T cell response are driven by individual HLA class I allelesIn: Frontiers in Immunology, Jg. 13, 2022, 1045498DOI (Open Access)
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Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis CIn: JCI Insight, Jg. 7, 2022, Nr. 2, e155432DOI (Open Access)
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Analysis of the long-term impact on cellular immunity in COVID-19-recovered individuals reveals a profound nkt cell impairmentIn: mBio, Jg. 12, 2021, Nr. 2, S. e00085 – 21DOI (Open Access)
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Multicenter Performance Evaluation of Elecsys Anti-HBc II, Anti-HCV II, HIV combi PT, HBsAg II, and Syphilis ImmunoassaysIn: Clinical Laboratory, Jg. 67, 2021, Nr. 11, S. 2594 – 2599
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Corrigendum: TLR2 Expression in Peripheral CD4+ T Cells Promotes Th17 Response and Is Associated with Disease Aggravation of Hepatitis B Virus-Related Acute-On-Chronic Liver Failure (Frontiers in Immunology, (2017), 8, 10.3389/fimmu.2017.01609)In: Frontiers in Immunology, Jg. 11, 2020, S. 1566DOI (Open Access)
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Effective Activation of Human Antigen-Presenting Cells and Cytotoxic CD8+ T Cells by a Calcium Phosphate-Based Nanoparticle Vaccine Delivery SystemIn: Vaccines, Jg. 8, 2020, Nr. 1, 110DOI, Online Volltext (Open Access)
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Erfolg durch körpereigene "Krieger*innen" : Natürliche Killerzellen im Kampf gegen eine Hepatitis-C-Virus-InfektionIn: Unikate: Berichte aus Forschung und Lehre, 2020, Nr. 54: Medizin: Infektionskrankheiten - ein globales Problem, S. 38 – 47DOI, Online Volltext (Open Access)
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NKG2Cpos NK Cells Regulate the Expansion of Cytomegalovirus-Specific CD8 T CellsIn: The Journal of Immunology (JI), Jg. 204, 2020, Nr. 11, S. 2910 – 2917
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An mTor-based immunosuppression reduces the antiviral efficacy of NS3/4A and NS5A inhibitors for HCV genotype 1b treatment in vitroIn: Journal of Hepatology, Jg. 70, 2019, Nr. 1 Suppl., S. e829
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Clinical Outcome and Viral Genome Variability of Hepatitis B Virus–Induced Acute Liver FailureIn: Hepatology, Jg. 69, 2019, Nr. 3, S. 993 – 1003
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Differential escape of HCV from CD8⁺ T cell selection pressure between China and Germany depends on the presenting HLA class I moleculeIn: Journal of Viral Hepatitis, Jg. 26, 2019, Nr. 1, S. 73 – 82DOI (Open Access)
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MMP2/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearanceIn: Journal of Hepatology, Jg. 71, 2019, Nr. 4, S. 685 – 698
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Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8⁺ T Cells and Evolve at the Population LevelIn: Gastroenterology, Jg. 156, 2019, Nr. 6, S. 1820 – 1833DOI (Open Access)
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Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cellsIn: JCI Insight, Jg. 4, 2019, Nr. 17, e129856DOI (Open Access)
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SEC14L2, a lipid-binding protein, regulates HCV replication in culture with inter- and intra-genotype variationsIn: Journal of Hepatology, Jg. 70, 2019, Nr. 4, S. 603 – 614
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Viral escape contributes to the failure of hepatitis D virus-specific CD8+ T-cells and drives evolution of HDVIn: Journal of Hepatology, Jg. 70, 2019, Nr. Suppl. 1, S. e21
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A Single-Nucleotide Polymorphism Upstream of the HLA-C Locus Is Associated With an Anti-Hepatitis C Virus-Seronegative State in a High-Risk Exposed CohortIn: The Journal of Infectious Diseases (JID), Jg. 218, 2018, Nr. 12, S. 2016 – 2019DOI (Open Access)
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Amino acid substitutions within HLA-B*27- restricted T cell epitopes prevent recognition by hepatitis delta virus-specific CD8⁺ T cellsIn: Journal of Virology, Jg. 92, 2018, Nr. 13, e01891-17DOI, Online Volltext (Open Access)
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Assessing the risk of CMV reactivation and reconstitution of antiviral immune response post bone marrow transplantation by the QuantiFERON-CMV-assay and real time PCRIn: Journal of Clinical Virology, Jg. 99-100, 2018, S. 61 – 66DOI (Open Access)
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CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infectionIn: Nature Communications, Jg. 9, 2018, 2561DOI (Open Access)
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Outcome of a hepatitis B vaccination program for clients of a drug consumption facilityIn: Journal of Clinical Virology, Jg. 106, 2018, S. 28 – 32
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Role of BK polyomavirus (BKV) and torque teno virus (TTV) in liver transplant recipients with renal impairmentIn: Journal of Medical Microbiology, Jg. 67, 2018, Nr. 10, S. 1496 – 1508
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S3-Leitlinie „Prophylaxe, Diagnostik und Therapie der Hepatitis-C-Virus (HCV) -Infektion“ : AWMF-Register-Nr.: 021/012In: Zeitschrift für Gastroenterologie, Jg. 56, 2018, Nr. 7, S. 756 – 838DOI (Open Access)
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The influence of immunosuppressants on direct-acting antiviral therapy is dependent on the hepatitis C virus genotypeIn: Transplant Infectious Disease, Jg. 20, 2018, Nr. 1, S. e12803
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Effects of the Mammalian Target of Rapamycin Inhibitor Everolimus on Hepatitis C Virus Replication In Vitro and In VivoIn: Transplantation Proceedings, Jg. 49, 2017, Nr. 8, S. 1947 – 1955
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HLA-Bw4 80(T) and multiple HLA-Bw4 copies combined with KIR3DL1 associate with spontaneous clearance of HCV infection in people who inject drugsIn: Journal of Hepatology, Jg. 67, 2017, Nr. 3, S. 462 – 470DOI, Online Volltext (Open Access)
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Liver transplantation from HCV RNA-positive donors in the era of interferon-free HCV therapeutics : A re-examination of the situationIn: Minerva Gastroenterologica e Dietologica, Jg. 63, 2017, Nr. 1, S. 55 – 61
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Lymphocytes Negatively Regulate NK Cell Activity via Qa-1b following Viral InfectionIn: Cell Reports, Jg. 21, 2017, Nr. 9, S. 2528 – 2540DOI (Open Access)
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Pre-exposure prophylaxis failure with tenofovir disoproxilIn: AIDS, Jg. 31, 2017, Nr. 1, S. 176 – 177
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TLR2 Expression in Peripheral CD4+ T Cells Promotes Th17 Response and Is Associated with Disease Aggravation of Hepatitis B Virus-Related Acute-On-Chronic Liver FailureIn: Frontiers in Immunology, Jg. 8, 2017, S. 1609DOI (Open Access)
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Transplantation of Renal Allografts From Organ Donors Reactive for HCV Antibodies to HCV-Negative Recipients: Safety and Clinical OutcomeIn: Kidney International Reports, Jg. 2, 2017, Nr. 1, S. 53 – 59DOI (Open Access)
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Distinct Escape Pathway by Hepatitis C Virus Genotype 1a from a Dominant CD8+ T Cell Response by Selection of Altered Epitope ProcessingIn: Journal of Virology, Jg. 90, 2016, Nr. 1, S. 33 – 42DOI (Open Access)
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Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infectionIn: Nature Chemical Biology, Jg. 12, 2016, Nr. 12, S. 1037 – 1045
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SeqFeatR for the Discovery of Feature-Sequence AssociationsIn: PLoS ONE, Jg. 11, 2016, Nr. 1, S. e0146409DOI (Open Access)
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Treatment of fulminant acute Hepatitis B with nucles(t)id analogues is safe and does not lead to secondary chronification of Hepatitis BIn: Zeitschrift für Gastroenterologie, Jg. 54, 2016, Nr. 12, S. 1306 – 1311
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Acute hepatitis C virus infection induces anti-host cell receptor antibodies with virus-neutralizing propertiesIn: Hepatology, Jg. 62, 2015, Nr. 3, S. 726 – 736DOI (Open Access)
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Adaptation of the Hepatitis B Virus Core Protein to CD8+ T-Cell Selection PressureIn: Hepatology, Jg. 62, 2015, Nr. 1, S. 47 – 56DOI (Open Access)
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All-In-One : Advanced preparation of Human Parenchymal and Non-Parenchymal Liver CellsIn: PLoS ONE, Jg. 10, 2015, Nr. 9, S. e0138655DOI (Open Access)
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Daclatasvir, Simeprevir and Ribavirin as a Promising Interferon-Free Triple Regimen for HCV Recurrence after Liver TransplantIn: Digestion, Jg. 91, 2015, Nr. 4, S. 326 – 333
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Daily low-dose tacrolimus is a safe and effective immunosuppressive regimen during telaprevir-based triple therapy for hepatitis C virus recurrence after liver transplantIn: Transplantation, Jg. 99, 2015, Nr. 4, S. 841 – 847DOI (Open Access)
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Decades after recovery from hepatitis B and HBsAg clearance the CD8+ T cell response against HBV core is nearly undetectableIn: Journal of Hepatology, Jg. 63, 2015, Nr. 1, S. 13 – 19
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Hepatitis E Virus Infection as a Possible Cause of Acute Liver Failure in EuropeIn: Clinical Gastroenterology and Hepatology, Jg. 13, 2015, Nr. 10, S. 1836 – 1842.e2
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Indeterminate acute liver failure : it may be Hepatitis EIn: Journal of Viral Hepatitis, Jg. 22, 2015, Nr. Suppl. 2, S. 12
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Management of telaprevir-based triple therapy for hepatitis C virus recurrence post liver transplantIn: World Journal of Hepatology, Jg. 7, 2015, Nr. 9, S. 1287 – 1296
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Natural prevalence of resistance-associated variants in hepatitis C virus NS5A in genotype 3a-infected people who inject drugs in GermanyIn: Journal of Clinical Virology, Jg. 70, 2015, S. 43 – 45
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A patient with severe respiratory failure caused by novel human coronavirusIn: Infection - A Journal of Infectious Disease, Jg. 42, 2014, Nr. 1, S. 203 – 206DOI, Online Volltext (Open Access)
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Genetic heterogeneity of hepatitis C virus cell entry receptors seems to have no influence on selection of virus variantsIn: Virology Journal, Jg. 11, 2014, Nr. 1, 50DOI (Open Access)
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HLA-B*27 is protective against HCV genotype 1 and 3 and associated with targeting of distinct genotype-specific CD8(+) cell epitopesIn: Journal of Hepatology, Jg. 60, 2014, Nr. Suppl. 1, S. 140
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HLA-B*27 subtype specificity determines targeting and viral evolution of a hepatitis C virus-specific CD8+ T cell epitopeIn: Journal of Hepatology, Jg. 60, 2014, Nr. 1, S. 22 – 29
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Hepatitis C virus hypervariable region 1 variants presented on hepatitis B virus capsid-like particles induce cross-neutralizing antibodiesIn: PLoS ONE, Jg. 9, 2014, Nr. 7, S. e102235DOI (Open Access)
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Impact of sequence variation in a dominant HLA-A*02-restricted epitope in hepatitis C virus on priming and cross-reactivity of CD8+ T cellsIn: Journal of Virology, Jg. 88, 2014, Nr. 19, S. 11080 – 11090
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KIR2DL3+NKG2A− natural killer cells are associated with protection from productive hepatitis C virus infection in people who inject drugsIn: Journal of Hepatology, Jg. 61, 2014, Nr. 3, S. 475 – 481
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Characterization of the CD8+T-cell immune response to the hepatitis B virus in the chronic and immunologically controlled infectionIn: Journal of Viral Hepatitis, Jg. 20, 2013, Nr. Suppl. 3, S. 34
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Das überlistete Immunsystem : Viren tricksen das Immunsystem aus, um chronische Infektionen zu etablierenIn: Unikate: Berichte aus Forschung und Lehre, 2013, Nr. 44: Medizin : 50 Jahre Universitätsklinikum Essen, S. 32 – 41DOI, Online Volltext (Open Access)
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HCV-Reinfektion nach Lebertransplantation : Management und erste Ergebnisse mit der Telaprevir-basierten Triple-TherapieIn: Deutsche Medizinische Wochenschrift - DMW, Jg. 138, 2013, Nr. 36, S. 1759 – 1764
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Identification of proteins that mediate the pro-viral functions of the interferon stimulated gene 15 in hepatitis C virus replicationIn: Antiviral Research, Jg. 100, 2013, Nr. 3, S. 654 – 661
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Immune ecasion of hepatitis delta from CD8+ t cell immune responseIn: Journal of Hepatology, Jg. 58, 2013, Nr. Suppl. 1, S. S20
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Susceptibility to chronic hepatitis C virus infection is influenced by sequence differences in immunodominant CD8+ T cell epitopesIn: Journal of Hepatology, Jg. 58, 2013, Nr. 1, S. 24 – 30
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The Pepsi Project : HVC resistance screening and prediction of pi-containing therapy outcomeIn: Journal of Hepatology, Jg. 58, 2013, Nr. Suppl. 1, S. S489 – S490
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Assays for laboratory confirmation of novel human coronavirus (HCOV-EMC) infectionsIn: Eurosurveillance, Jg. 17, 2012, Nr. 49, S. 2 – 10DOI (Open Access)
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Escape from a dominant hla-b*15-restricted cd8+ t cell response against hepatitis c virus requires compensatory mutations outside the epitopeIn: Journal of Virology, Jg. 86, 2012, Nr. 2, S. 991 – 1000DOI, Online Volltext (Open Access)
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Interleukin 21 augments the hepatitis B virus-specific CD8+ T-cell response in vitro in patients coinfected with HIV-1In: AIDS, Jg. 26, 2012, Nr. 17, S. 2145 – 2153
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Prevalence of hepatitis e virus infection in pediatric solid organ transplant recipients : a single-center experienceIn: Pediatric Transplantation, Jg. 16, 2012, Nr. 7, S. 742 – 747
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Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population LevelIn: Journal of Virology, Jg. 85, 2011, Nr. 9, S. 4634
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CD8+ T-Cell Response Promotes Evolution of Hepatitis C Virus Nonstructural ProteinsIn: Gastroenterology, Jg. 140, 2011, Nr. 7, S. 2064 – 2073
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Characterization of CD8+ T-cell response in acute and resolved hepatitis A virus infectionIn: Journal of Hepatology, Jg. 54, 2011, Nr. 2, S. 201 – 208
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Hepatocyte apoptotic bodies encasing nonstructural HCV proteins amplify hepatic stellate cell activation : Implications for chronic hepatitis CIn: Journal of Viral Hepatitis, Jg. 18, 2011, Nr. 11, S. 760 – 767
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Reply to Colson and GerolamiIn: The Journal of Infectious Diseases (JID), Jg. 203, 2011, Nr. 9, S. 1342 – 1343DOI (Open Access)
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Spontaneous Control of HCV Is Associated With Expression of HLA-B*57 and Preservation of Targeted EpitopesIn: Gastroenterology, Jg. 140, 2011, Nr. 2, S. 686 – 696.e1
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The predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5Δ32 mutationIn: Journal of Hepatology, Jg. 55, 2011, Nr. 6, S. 1201 – 1206
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125 IL28B Polymorphism is associated with jaundice during acute HCV infection and is a strong predictor for spontaneous clearance in the prospective german anti-d cohortIn: Journal of Hepatology, Jg. 52, 2010, Nr. Suppl. 1, S. S56
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A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundiceIn: Gastroenterology, Jg. 139, 2010, Nr. 5, S. 1586 – 1592
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Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiationIn: PLoS Pathogens, Jg. 6, 2010, Nr. 6DOI (Open Access)
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Hepatitis C virus recombinants are rare even among intravenous drug usersIn: Journal of Medical Virology, Jg. 82, 2010, Nr. 2, S. 232 – 238
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Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitopeIn: Hepatology, Jg. 51, 2010, Nr. 1, S. 54 – 62
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The resistance mutation R155K in the NS3/4A protease of hepatitis C virus also leads the virus to escape from HLA-A*68-restricted CD8 T cellsIn: Antiviral Research, Jg. 87, 2010, Nr. 2, S. 272 – 275
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Escape from HLA-B*08-restricted CD8 T cells by hepatitis C virus is associated with fitness costsIn: Journal of Virology, Jg. 82, 2008, Nr. 23, S. 11803 – 11812DOI (Open Access)
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Das Lungenkrebsrisiko in der Hütten- und metallverarbeitenden Industrie - Ergebnisse einer Fall-Kontroll-Studie.In: Verhandlungen der Deutschen Gesellschaft für Arbeitsmedizin e.V., 1987, S. 407 – 411
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KIR3DL1 in Combination with HLA-BW4-80T is Associated with Superior Functionality of NK Cells and Spontaneous Immune Control of HCV Infection in People who Inject DrugsIn: Journal of Hepatology. Amsterdam; Copenhagen; Oxford: Elsevier, Jg. 64, 2016, Nr. 2, Suppl., S. S515
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All-in-one liver cell preparation : high quality of functional primary human hepatocytes, liver sinusoidal endothelial cells, Kupffer cells and hepatic stellate cellsIn: Hepatology. Hoboken: Wiley & Sons, Jg. 60, 2014, Nr. Suppl. 1, S. 814A
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Daclatasvir, Simeprevir and Ribavirin as a new IFN-free triple regimen for HCV recurrence after liver transplantation : First results of safety and efficacy in 6 patientsIn: Hepatology. Hoboken: Wiley & Sons, Jg. 60, 2014, Nr. Suppl. 1, S. 697ADOI (Open Access)
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Daclatasvir, Simeprevir and Ribavirin as a new IFN-free triple regimen for HCV recurrence after liver transplantation : First results of safety and efficacy in 6 patients
23rd Annual Meeting of the German Transplantation Society, Mannheim, Germany, 16–18 October 2014,In: Transplant International. Lausanne: Frontiers Media, Jg. 27, 2014, Nr. Suppl. 3, S. 19 -
Decades after recovery from acute hepatitis B virus (HBV) infection the CD8+T cell response against HBV core is nearly undetectableIn: Hepatology. Hoboken: Wiley & Sons, Jg. 60, 2014, Nr. Suppl. 1, S. 231A – 232ADOI (Open Access)
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HIV-infection during treatment of a chronic hepatitis B virus infection : implications for PrEP?In: Journal of the International AIDS Society. Hoboken: Wiley, Jg. 15, 2012, Nr. S4, S. P234
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Primary human hepatocytes inhibit expansion of virus-specific CD8+ T cells in vitroIn: Journal of Hepatology. Amsterdam; Copenhagen; Oxford: Elsevier, Jg. 56, 2012, Nr. Supplement 2, S. S318
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Transcriptional-metabolic reprogramming of HCV-infection from primary human hepatocytes co-cultures to clinical samplesIn: Journal of Hepatology. Amsterdam; Copenhagen; Oxford: Elsevier, Jg. 56, 2012, Nr. Supplement 2, S. S336
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Populational analysis reveals a link between complex viral escape from CD8+ T-Cell responses and protection in HCV infectionIn: Journal of Hepatology. Amsterdam; Copenhagen; Oxford: Elsevier, Jg. 54, 2011, Nr. Suppl. 1, S. S2
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703 Evidence for differential adaptation of Hepatitis C virus in populations with different HLA-class i-backgroundIn: Journal of Hepatology. Amsterdam; Copenhagen; Oxford: Elsevier, Jg. 52, 2010, Nr. Suppl. 1, S. S273
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Acute hepatitis a is associated with a multispecific CD8+ T cell response in HLA-A2 positive patients
45th annual meeting of the European Association for the Study of the Liver (EASL),In: Journal of Hepatology. Amsterdam; Copenhagen; Oxford: Elsevier, Jg. 52, 2010, Nr. Suppl. 1, S. S39 -
Methodik von Fall-Kontroll-Studien zur Aufdeckung kleinerer Risiken insbesondere in der Umweltepidemiologie. : Gemeinsamer Workshop der AG "Epidemiologie" der GMDS und des Medizinsichen Instituts für Umwelthygiene.In: Methodische Aspekte in der Umweltepidemiologie. / Wichmann, Heinz E. (Hrsg.). Düsseldorf: Springer-Verlag, 1986, S. 1 – 16
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Untersuchung der Interaktion zwischen der zellulären Immunantwort und der Evolution des Hepatis C VirusDuisburg, Essen, 2010
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Untersuchung der Interaktion der zellulären Immunantwort und der Evolution des Hepatitis C VirusDuisburg, Essen; Duisburg Essen, 2009