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Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Metzenmacher, Martin; Kopp, Hans-Georg; Griesinger, Frank; Reinmuth, Niels; Sebastian, Martin; Serke, Monika; Waller, Cornelius Florian; Thomas, Michael; Eggert, Jochen; Schmid-Bindert, Gerald; Hoiczyk, Mathias; Christoph, Daniel; Kimmich, Martin; Deuß, Burkhard; Seifert, Stephanie; Held, Swantje; Schuler, Martin; Herold, Thomas; Breitenbücher, Frank; Eberhardt, Wilfried
    A randomized, multicenter phase II study comparing efficacy, safety and tolerability of two dosing regimens of cisplatin and pemetrexed in patients with advanced or metastatic non-small-cell lung cancer
    In: Therapeutic Advances in Medical Oncology Jg. 13 (2021)
  • Welt, Anja; Wiesweg, Marcel; Theurer, Sarah; Abenhardt, Wolfgang; Groschek, Matthias; Müller, Lothar; Schröder, Jan; Tewes, Mitra; Chiabudini, Marco; Potthoff, Karin; Bankfalvi, Agnes; Marschner, Norbert; Schuler, Martin; Breitenbücher, Frank
    Buparlisib in combination with tamoxifen in pretreated patients with hormone receptor-positive, HER2-negative advanced breast cancer molecularly stratified for PIK3CA mutations and loss of PTEN expression
    In: Cancer Medicine Jg. 9 (2020) Nr. 13, S. 4527 - 4539
  • Nothdurft, Silke; Thumser-Henner, Clotilde; Breitenbücher, Frank; Okimoto, Ross A.; Dorsch, Madeleine; Opitz, Christiane A.; Sadik, Ahmed; Esser, Charlotte; Hölzel, Michael; Asthana, Saurabh; Forster, Jan; Beisser, Daniela; Kalmbach, Sophie; Grüner, Barbara M.; Bivona, Trever G.; Schramm, Alexander; Schuler, Martin
    Functional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis
    In: Oncogenesis Jg. 9 (2020) Nr. 11, S. 102
  • Oezkan, Filiz; Herold, Thomas; Darwiche, Kaid; Eberhardt, Wilfried; Worm, Karl; Christoph, Daniel; Wiesweg, Marcel; Freitag, Lutz; Schmid, Kurt Werner; Theegarten, Dirk; Hager, Thomas; Koenig, Michael J.; He, Kai; Taube, Christian; Schuler, Martin; Breitenbücher, Frank
    Rapid and Highly Sensitive Detection of Therapeutically Relevant Oncogenic Driver Mutations in EBUS-TBNA Specimens From Patients With Lung Adenocarcinoma
    In: Clinical Lung Cancer Jg. 19 (2018) Nr. 6, S. e879 - e884
  • Breitenbücher, Frank; Von Pawel, Joachim; Sebastian, Martin; Kortsik, Cornelius; Ting, Saskia; Kasper, Stefan; Wohlschläger, Jeremias; Worm, Karl; Morresi-Hauf, Alicia; Schad, Arno; Westerwick, Daniela; Wehler, Beatrice; Werner, Martin; Munzert, Gerd; Gaschler-Markefski, Birgit; Schmid, Kurt Werner; Schuler, Martin
    Comprehensive biomarker analyses in patients with advanced or metastatic non-small cell lung cancer prospectively treated with the polo-like Kinase 1 Inhibitor BI2536
    In: Oncology Research and Treatment Jg. 40 (2017) Nr. 7-8, S. 435 - 439
  • Wieczorek, Sarah A.; Breitenbücher, Frank; Soni, Aashish; Paul-Konietzko, Katja; Ziegler, Sophie; Sak, Ali; Iliakis, George; Schuler, Martin
    Deregulated BCL-2 family proteins impact on repair of DNA double-strand breaks and are targets to overcome radioresistance in lung cancer
    In: Journal of Cancer Research and Clinical Oncology Jg. 143 (2017) Nr. 9, S. 1733 - 1744
  • Okimoto, Ross A; Breitenbücher, Frank; Olivas, Victor R; Wu, Wei; Gini, Beatrice; Hofree, Matan; Asthana, Saurabh; Hrustanovic, Gorjan; Flanagan, Jennifer; Tulpule, Asmin; Blakely, Collin M; Haringsma, Henry J; Simmons, Andrew D; Gowen, Kyle; Suh, James; Miller, Vincent A; Ali, Siraj; Schuler, Martin; Bivona, Trever G.
    Inactivation of Capicua drives cancer metastasis
    In: Nature Genetics Jg. 49 (2017) Nr. 1, S. 87 - 96
  • Kasper, Stefan; Reis, Henning; Ziegler, Sophie; Nothdurft, Silke; Mueller, Andre; Goetz, Moritz; Wiesweg, Marcel; Phasue, Jeannette; Ting, Saskia; Wieczorek, Sarah; Even, Anna; Worm, Karl; Pogorzelski, Michael; Breitenbuecher, Sandra; Meiler, Johannes; Paul, Andreas; Trarbach, Tanja; Schmid, Kurt Werner; Breitenbücher, Frank; Schuler, Martin
    Molecular dissection of effector mechanisms of RAS-mediated resistance to anti-EGFR antibody therapy
    In: OncoTarget Jg. 8 (2017) Nr. 28, S. 45898 - 45917
  • Oezkan, Filiz; Herold, Thomas; Darwiche, Kaid; Eberhardt, Wilfried; Christoph, Daniel; Worm, Karl; Freitag, Lutz; Schmid, Kurt Werner; Hager, Thomas; Breitenbücher, Frank; Schuler, Martin
    Rapid and Highly Sensitive EGFRdelEx19 and KRAS Exon 2 Mutation Detection in EBUS-TBNA Specimen of Lung Adenocarcinoma
    In: Journal of Thoracic Oncology Jg. 12 (2017) Nr. Suppl. 1, S. S1201 - S1201
  • Köhler, Jens; Schuler, Martin; Gauler, Thomas; Nöpel-Dünnebacke, Stefanie; Ahrens, Maike; Hoffmann, Andreas-Claudius; Kasper, Stefan; Nensa, Felix; Gomez, Benedikt; Hahnemann, Maria; Breitenbücher, Frank; Cheufou, Danjouma; Özkan, Filiz; Darwiche, Kaid; Hoiczyk, Mathias; Reis, Henning; Welter, Stefan; Eberhardt, Wilfried; Eisenacher, Martin; Teschler, Helmut; Stamatis, Georgios; Schmiegel, Wolff; Hahn, Stephan Albrecht; Baraniskin, Alexander
    Circulating U2 small nuclear RNA fragments as a diagnostic and prognostic biomarker in lung cancer patients
    In: Journal of Cancer Research and Clinical Oncology Jg. 142 (2016) Nr. 4, S. 795 - 805
  • Breitenbücher, Frank; Schuler, Martin; Markova, Boyka
    Alternative tumor suppressor mechanisms in lung carcinomas - modulation of senescence by growth factor-induced signaling
    In: Cancer Research Jg. 75 (2015) Nr. 15 Suppl., S. 1033
  • Ullrich, Nico; Löffek, Stefanie; Horn, Susanne; Ennen, Marie; Sánchez‐del‐Campo, Luis; Zhao, Fang; Breitenbücher, Frank; Davidson, Irwin; Singer, Bernhard B.; Schadendorf, Dirk; Goding, Colin R.; Helfrich, Iris
    MITF is a critical regulator of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in malignant melanoma
    In: Pigment Cell and Melanoma Research Jg. 28 (2015) Nr. 6, S. 736 - 740
  • Pogorzelski, M.; Ting, Saskia; Gauler, Thomas; Breitenbücher, Frank; Vossebein, I.; Hoffarth, S.; Markowetz, J.; Lang, Stephan; Bergmann, Christoph; Brandau, Sven; Abu-Jawad, J.; Schmid, Kurt Werner; Schuler, Martin; Kasper, Stefan
    Molecular dissection of the impact of frequent genetic alterations on the response of head and neck cancers to anti-epidermal growth factor receptor-directed therapies
    In: Oral Oncology Jg. 51 (2015) Nr. 5, S. e39
  • Bauer, Sebastian; Herold, Thomas; Mühlenberg, Thomas; Reis, Anna-Carina; Falkenhorst, Johanna; Backs, Miriam; Ketzer, Julia; Breitenbücher, Frank; Schuler, Martin; Grunewald, Susanne
    Plasma sequencing to detect a multitude of secondary KIT resistance mutations in metastatic gastrointestinal stromal tumors (GIST)
    In: Journal of Clinical Oncology (JCO) Jg. 33 (2015) Nr. 15_suppl, S. 10518
  • Hoffmann, Gesine; Breitenbücher, Frank; Schuler, Martin; Ehrenhofer-Murray, Ann
    A Novel Sirtuin 2 (SIRT2) Inhibitor with p53-dependent Pro-apoptotic Activity in Non-small Cell Lung Cancer
    In: The Journal of Biological Chemistry (JBC) Jg. 289 (2014) Nr. 8, S. 5208 - 5216
  • Breitenbücher, Frank; Hoffarth, Sandra; Worm, Karl; Cortes-Incio, Diana; Gauler, Thomas; Köhler, Jens; Herold, Thomas; Kurt Werner, Schmid; Freitag, Lutz; Kasper, Stefan; Schuler, Martin
    Development of a Highly Sensitive and Specific Method for Detection of Circulating Tumor Cells Harboring Somatic Mutations in Non-Small-Cell Lung Cancer Patients
    In: PLoS ONE Jg. 9 (2014) Nr. 1, S. e85350
  • Göbel, C.; Breitenbücher, Frank; Kalkavan, H.; Hähnel, Patricia S.; Kasper, Stefan; Hoffarth, Christian; Merches, Katja; Schild, Hans-Jörg; Lang, Karl S.; Schuler, Martin
    Functional expression cloning identifies COX-2 as a suppressor of antigen-specific cancer immunity
    In: Cell Death and Disease Jg. 5 (2014) Nr. 12, 1568
  • Pogorzelski, M-; Ting, Saskia; Gauler, Thomas; Breitenbücher, Frank; Vossebein, I.; Hoffarth, S.; Markowetz, J.; Lang, S.; Bergmann, Christoph; Brandau, Sven; Abu Jawad, Jehad; Schmid, Kurt Werner; Schuler, Martin; Kasper, Stefan
    Impact of human papilloma virus infection on the response of head and neck cancers to anti-epidermal growth factor receptor antibody therapy
    In: Cell Death and Disease Jg. 5 (2014) Nr. 2, e1091
  • Simon, Susanne; Grabellus, Florian; Ferrera, Loretta; Galietta, Luis; Schwindenhammer, Benjamin; Mühlenberg, Thomas; Täger, Georg; Eilers, Grant; Treckmann, Jürgen-Walter; Breitenbücher, Frank; Schuler, Martin; Taguchi, Takahiro; Fletcher, Jonathan A.; Bauer, Sebastian
    DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
    In: Cancer Research Jg. 73 (2013) Nr. 12, S. 3661 - 3670
  • Wiesweg, Marcel; Ting, Saskia; Reis, Henning; Worm, Karl; Kasper, Stefan; Tewes, Mitra; Welt, Anja; Richly, Heike; Meiler, Johannes; Bauer, Sebastian; Hense, Jörg; Gauler, Thomas; Köhler, Jens; Eberhardt, Wilfried; Darwiche, Kaid; Freitag, Lutz; Stamatis, Georgios; Breitenbücher, Frank; Wohlschläger, Jeremias; Theegarten, Dirk; Derks, Cordula; Cortes-Incio, Diana; Linden, Gabriele; Skottky, Silke; Lütkes, Peter; Dechene, Alexander; Paul, Andreas; Markus, Peter; Schmid, Kurt Werner; Schuler, Martin
    Feasibility of preemptive biomarker profiling for personalised early clinical drug development at a Comprehensive Cancer Center
    In: European Journal of Cancer (EJC) Jg. 49 (2013) Nr. 15, S. 3076 - 3082
  • Kasper, Stefan; Breitenbücher, Frank; Reis, Henning; Brandau, Sven; Worm, K.; Köhler, J.; Paul, Andreas; Trarbach, Tanja; Schmid, Kurt Werner; Schuler, Martin
    Oncogenic RAS simultaneously protects against anti-EGFR antibody-dependent cellular cytotoxicity and EGFR signaling blockade
    In: Oncogene Jg. 32 (2013) Nr. 23, S. 2873 - 2881
  • Molzan, M.; Kasper, Stefan; Röglin, L.; Skwarczynska, M.; Sassa, T.; Inoue, T.; Breitenbücher, Frank; Ohkanda, J.; Kato, N.; Schuler, Martin; Ottmann, C.
    Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers
    In: ACS Chemical Biology Jg. 8 (2013) Nr. 9, S. 1869 - 1875
  • Kohler, J.; Worm, K.; Gauler, Thomas; Hoiczyk, M.; Theegarten, Dirk; Eberhardt, Wilfried; Hense, Jörg; Breitenbücher, Frank; Schmid, Kurt Werner; Schuler, Martin
    Impact of EGFR mutation status on clinical benefit from BIBW 2992 in patients (PTS) with advanced non-small lung cancer (NSCLC) progressing after chemotherapy (CTX) and erlotinib (E) or gefitinib (G) - a single center experience
    In: Annals of Oncology Jg. 23 (2012) Nr. Suppl. 9, S. 437 - 438
  • Meiler, Johannes; Guyot, M.; Hoffarth, S.; Wesarg, E.; Höhn, Y.; Breitenbücher, Frank; Schuler, Martin
    Individual dose and scheduling determine the efficacy of combining cytotoxic anticancer agents with a kinase inhibitor in non-small-cell lung cancer
    In: Journal of Cancer Research and Clinical Oncology Jg. 138 (2012) Nr. 8, S. 1385 - 1394
  • Markova, Boyka; Hähnel, Patricia S.; Kasper, Stefan; Herbertz, Stephan; Schuler, Martin; Breitenbücher, Frank
    Pharmacologic inhibition of mTOR antagonizes the cytotoxic activity of pemetrexed in non-small cell lung cancer
    In: Journal of Cancer Research and Clinical Oncology Jg. 138 (2012) Nr. 4, S. 545 - 554
  • Kasper, Stefan; Breitenbücher, Frank; Heidel, F.; Hoffarth, S.; Markova, B.; Schuler, Martin; Fischer, T.
    Targeting MCL-1 sensitizes FLT3-ITD-positive leukemias to cytotoxic therapies
    In: Blood Cancer Journal Jg. 2 (2012) Nr. 3, S. e60
  • Kasper, Stefan; Reis, Henning; Breitenbücher, Frank; Markowetz, J.; Pogorzelski, M.; Trarbach, Tanja; Worm, K.; Schmid, Kurt Werner; Schuler, Martin
    Targeting the anti-apoptotic protein BCL-XL to overcome RAS mediated resistance to anti-EGFR antibody therapy in colorectal cancer
    In: Onkologie Jg. 35 (2012) Nr. Suppl. 6, S. 253
  • Wiesweg, Marcel; Kasper, Stefan; Wohlschläger, Jeremias; Ting, Saskia; Skottky, S.; Worm, K.; Derks, C.; Tewes, Mitra; Breitenbücher, Frank; Gauler, Thomas; Eberhardt, Wilfried; Ahrens, M.; Hoiczyk, M.; Meiler, Johannes; Hense, Jörg; Welt, Anja; Theegarten, Dirk; Freitag, Lutz; Kimmig, Rainer; Schmid, Kurt Werner; Schuler, Martin
    VVTZ-Tumorprofil - First results of a preemptive biomarker profiling program in relation to personalized clinical drug development at a large German Comprehensive Cancer Center
    In: Onkologie Jg. 35 (2012) Nr. Suppl. 6, S. 204 - 204
  • Köhler, Jens; Hoffmann, Andreas-Claudius; Breitenbücher, Frank
    Zug um Zug : Tumorzellen in Schach halten – Moderne Konzepte zur Behandlung des Lungenkarzinoms
    In: Unikate: Berichte aus Forschung und Lehre (2012) Nr. 42: Translationale Krebsforschung: Auf dem Weg zu neuen Therapien, S. 90 - 97
  • Christoph, DanielC; Kasper, Stefan; Gauler, ThomasC; Breitenbücher, Frank; Engelhard, Marianne; Theegarten, Dirk; Pöttgen, Christoph; Hepp, Rodrigo; Peglow, Anja; Loewendick, Heike; Hirsch, FredR; Schuler, Martin; Eberhardt, Wilfried; Wohlschläger, Jeremias
    Evaluation of Betav-Tubulin expression as novel predictive biomarker for clinical benefit from treatment with taxanes in non-small cell lung cancer
    In: Journal of Thoracic Oncology Jg. 6 (2011) Nr. Suppl. 6, S. 1078
  • Becker, Silvan; Markova, Boyka; Wiewrodt, Rainer; Hoffarth, Sandra; Hähnel, Patricia S.; Pleiner, Sina; Schmidt, Lars Hennig; Breitenbücher, Frank; Schuler, Martin
    Functional and Clinical Characterization of the Putative Tumor Suppressor WWOX in Non-small Cell Lung Cancer
    In: Journal of Thoracic Oncology Jg. 6 (2011) Nr. 12, S. 1976 - 1983
  • Breitenbücher, Frank; Hoffarth, S.; Gauler, Thomas; Stergar, S. L.; Kasper, Stefan; Kohler, J.; Worm, K.; Marten, A.; Schmid, Kurt Werner; Schuler, Martin
    Highly sensitive detection of somatic epidermal growth factor receptor (EGFR) gene mutations in circulating tumor cells (CTC) from patients with non-small cell lung cancer treated with cisplatin/pemetrexed or afatinib
    In: Journal of Thoracic Oncology Jg. 6 (2011) Nr. Suppl. 6, S. S956 - S957
  • Kasper, Stefan; Breitenbücher, Frank; Even, A.; Pogorzelski, M.; Hoffarth, S.; Stergar, S. L.; Trarbach, Tanja; Schuler, Martin
    Pharmacological Inhibition of NF-k and PLK-1 to the Opening of the RAS-mediated Resistance to anti-EGFR Antibody therapies in Colorectal cancer *
    In: Der Internist Jg. 52 (2011) Nr. 6, S. 726 - 726
  • Schuler, Martin; Breitenbücher, Frank; Trarbach, Tanja; Brandau, Sven; Schmid, Kurt Werner; Kasper, Stefan
    Simultaneous protection against anti-EGFR antibody-dependent cellular cytotoxicity and EGFR-signaling blockade by oncogenic RAS
    In: Journal of Clinical Oncology (JCO) Jg. 29 (2011) Nr. Suppl. 4, S. 440
  • Köhler, Jens; Breitenbücher, Frank; Schuler, Martin
    Individualisierte Therapie für Patienten mit fortgeschrittenen Lungenkarzinomen
    In: TumorDiagnostik & Therapie Jg. 31 (2010) Nr. 2, S. 79 - 87
  • Markova, Boyka A.; Albers, Corinna; Breitenbücher, Frank; Melo, Junia V.; Brümmendorf, Tim H.; Heidel, Florian H.; Lipka, Daniel B.; Duyster, Justus; Huber, Christopher H.; Fischer, Thomas
    Novel pathway in Bcr-Abl signal transduction involves Akt-independent, PLC-γ1-driven activation of mTOR/p70S6-kinase pathway
    In: Oncogene Jg. 29 (2010) Nr. 5, S. 739 - 751
  • Breitenbücher, Frank; Schnittger, Susanne; Grundler, Rebekka; Markova, Boyka; Carius, Birgit; Brecht, Alexandra; Duyster, Justus; Haferlach, Torsten; Huber, Christoph; Fischer, Thomas
    Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor
    In: Blood Jg. 113 (2009) Nr. 17, S. 4074 - 4077
  • Abstracts

  • Nothdurft, S.; Breitenbücher, Frank; Okimoto, R.; Bivona, T.; Grüner, Barbara M.; Hoelzel, M.; Forster, J.; Kalmbach, S.; Schramm, Alexander; Schuler, Martin
    MA17.07 Identification of AHR as a Novel Regulator of Lung Cancer Metastasis
    In: Journal of Thoracic Oncology Jg. 14 (2019) Nr. 10, Supplement, S. S319
  • Köhler, Johannes; Schuler, Martin; Gauler, Thomas; Nopel-Dunnebacke, S.; Hoffmann, Andreas-Claudius; Kasper, Stefan; Nensa, Felix; Gomez, Benedikt; Hahnemann, M.; Breitenbücher, Frank; Cheufou, D.; Ozkan, F.; Darwiche, Kaid; Hoiczyk, M.; Welter, Stefan; Eberhardt, Wilfried; Teschler, Helmut; Stamatis, Georgios; Hahn, S. A.; Baraniskin, A.;
    Circulating U2 small nuclear RNA fragments as a diagnostic and prognostic biomarker in lung cancer patients
    Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, 10.-14. Oktober 2014, Hamburg,
    In: Oncology Research and Treatment Jg. 37 (2014) Nr. Suppl. 5, S. 226 - 227
  • Gauler, Thomas; Pogorzelski, M.; Ting, Saskia; Breitenbücher, Frank; Vossebein, I.; Hoffarth, S.; Lang, Stephan; Bergmann, Christoph; Abu Jawad, Jehad; Markowetz, J.; Schmid, Kurt Werner; Schuler, Martin; Kasper, Stefan;
    Impact of human papilloma virus infection on the response of head and neck cancers (HNSCC) to anti-epidermal growth factor receptor (EGFR) antibody therapy
    31. Deutscher Krebskongress iKON - intelligente Konzepte in der Onkologie, 19.-22. Februar 2014, Berlin,
    In: Oncology Research and Treatment Jg. 37 (2014) Nr. Suppl. 1, S. 76
  • Kasper, Stefan; Breitenbücher, Frank; Markowetz, J.; Reis, Henning; Ting, Saskia; Worm, K.; Meiler, Johannes; Schmid, Kurt Werner; Trarbach, Tanja; Schuler, Martin;
    Molecular dissection of effector mechanisms of RAS-induced resistance to monoclonal anti-EGFR antibodies
    Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie, 18.-22. Oktober 2013, Wien, Österreich,
    In: Onkologie Jg. 36 (2013) Nr. Suppl. 7, S. 116 - 117
  • Simon, Susanne; Fererra, Loretta; Galietta, Luis; Grabellus, Florian; Breitenbücher, Frank; Schuler, Martin; Fletcher, Jonathan; Bauer, Sebastian
    Functional characterization of DOG1 in Gastrointestinal Stromal Tumors (GIST)
    In: Cancer Research Jg. 72 (2012) Nr. 8, Suppl., S. 1824
  • Falkenhorst, Johanna; Mühlenberg, Thomas; Simon, Susanne; Ecken, Sonja; Henze, Jörn; Grabellus, Florian; Breitenbücher, Frank; Schuler, Martin; Fletcher, Jonathan A.; Bauer, Sebastian
    Inhibitors of apoptosis (IAPs) in gastrointestinal stromal tumors
    In: Cancer Research Jg. 72 (2012) Nr. 8, Suppl., S. 3855 - 3855
  • Markova, B.; Hahnel, P. S.; Herbertz, S.; Schuler, Martin; Breitenbücher, Frank
    Influence of Everolimus and Pemetrexed on Thymidylate Synthase expression as well as on Proliferation and survival of non-small cell ling Cancer Cells
    In: Journal of Thoracic Oncology Jg. 5 (2010) Nr. Suppl. 1, S. S56 - S57