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Dr. rer. nat. Katrin Becker-Flegler

UK-Essen

Anschrift
Hufelandstr. 55
45122 Essen
Telefon
723-1637
Telefax
723-5974
E-Mail
katrin.becker-flegler@uni-due.de

Funktionen

  • Gruppe der akademischen Mitarbeiterinnen und Mitarbeiter, Institut für Molekularbiologie (Tumorforschung)

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Zydek, Isabel; Thümmler, Laura; Beckmann, Nadine; Sehl, Carolin; Soddemann, Matthias; Grüneberg, Rabea; Elsner, Carina; Kamler, Markus; Dittmer, Ulf; Witzke, Oliver; Kadow, Stephanie; Gulbins, Erich; Becker, Katrin Anne; Krawczyk, Adalbert; Becker-Flegler, Katrin
    Amitriptyline potently neutralizes distinct SARS-CoV-2 variants including D614G, Omicron BA.5, and Omicron XBB.1
    In: Frontiers in Microbiology, Jg. 16, 2025, 1631947
    DOI, Online Volltext (Open Access)
  • Thümmler, Laura; Beckmann, Nadine; Sehl, Carolin; Soddemann, Matthias; Braß, Peer; Bormann, Maren; Brochhagen, Leonie; Elsner, Carina; Hoertel, Nicolas; Cougoule, Céline; Ciesek, Sandra; Widera, Marek; Dittmer, Ulf; Lindemann, Monika; Horn, Peter A.; Witzke, Oliver; Kadow, Stephanie; Kamler, Markus; Gulbins, Erich; Becker, Katrin Anne; Krawczyk, Adalbert
    Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 Variants
    In: Viruses, Jg. 16, 2024, Nr. 4, 545
    DOI (Open Access)
  • Wilson, Gregory C.; Patel, Sameer H.; Wang, Jiang; Xu, Kui; Turner, Kevin M.; Becker-Flegler, Katrin; Carpinteiro, Alexander; Szabo, Ildiko; Ahmad, Syed A.; Gulbins, Erich
    Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma
    In: Journal of Molecular Medicine, Jg. 101, 2023, Nr. 7, S. 891 – 903
    DOI (Open Access)
  • Hoertel, Nicolas; Rezaei, Katayoun; Sánchez-Rico, Marina; Delgado-Álvarez, Alfonso; Kornhuber, Johannes; Gulbins, Erich; Olfson, Mark; Ouazana-Vedrines, Charles; Carpinteiro, Alexander; Cougoule, Céline; Becker, Katrin Anne; Alvarado, Jesús M.; Limosin, Frédéric
    Medications Modulating the Acid Sphingomyelinase/Ceramide System and 28-Day Mortality among Patients with SARS-CoV-2: An Observational Study
    In: Pharmaceuticals, Jg. 16, 2023, Nr. 8, 1107
    DOI (Open Access)
  • Hoertel, Nicolas; Sánchez-Rico, Marina; de la Muela, Pedro; Abellán, Miriam; Blanco, Carlos; Leboyer, Marion; Cougoule, Céline; Gulbins, Erich; Kornhuber, Johannes; Carpinteiro, Alexander; Becker, Katrin Anne; Vernet, Raphaël; Beeker, Nathanaël; Neuraz, Antoine; Alvarado, Jesús M.; Herrera-Morueco, Juan José; Airagnes, Guillaume; Lemogne, Cédric; Limosin, Frédéric
    Risk of Death in Individuals Hospitalized for COVID-19 With and Without Psychiatric Disorders : An Observational Multicenter Study in France
    In: Biological Psychiatry Global Open Science, Jg. 3, 2023, Nr. 1, S. 56 – 67
    DOI (Open Access)
  • Patel, Sameer H.; Bachmann, Magdalena; Kadow, Stephanie; Wilson, Gregory C.; Abdel-Salam, Mostafa M. L.; Xu, Kui; Keitsch, Simone; Soddemann, Matthias; Wilker, Barbara; Becker, Katrin Anne; Carpinteiro, Alexander; Ahmad, Syed A.; Szabo, Ildiko; Gulbins, Erich
    Simultaneous targeting of mitochondrial Kv1.3 and lysosomal acid sphingomyelinase amplifies killing of pancreatic ductal adenocarcinoma cells in vitro and in vivo
    In: Journal of Molecular Medicine, Jg. 101, 2023, Nr. 3, S. 295 – 310
    DOI (Open Access)
  • Hoertel, Nicolas; Sánchez-Rico, Marina; Kornhuber, Johannes; Gulbins, Erich; Reiersen, Angela M.; Lenze, Eric J.; Fritz, Bradley A.; Jalali, Farid; Mills, Edward J.; Cougoule, Céline; Carpinteiro, Alexander; Mühle, Christiane; Becker, Katrin Anne; Boulware, David R.; Blanco, Carlos; Alvarado, Jesús M.; Strub-Wourgaft, Nathalie; Lemogne, Cédric; Limosin, Frédéric
    Antidepressant Use and Its Association with 28-Day Mortality in Inpatients with SARS-CoV-2 : Support for the FIASMA Model against COVID-19
    In: Journal of Clinical Medicine (JCM), Jg. 11, 2022, Nr. 19, 5882
    DOI (Open Access)
  • Carstens, Henning; Kalka, Katharina; Verhaegh, Rabea; Schumacher, Fabian; Soddemann, Matthias; Wilker, Barbara; Keitsch, Simone; Sehl, Carolin; Kleuser, Burkhard; Hübler, Michael; Rauen, Ursula; Becker, Anne Katrin; Koch, Achim; Gulbins, Erich; Kamler, Markus
    Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs
    In: PLoS ONE, Jg. 17, 2022, e0271620
    DOI (Open Access)
  • Hose, Matthias; Günther, Anne; Naser, Eyad; Schumacher, Fabian; Schönberger, Tina; Falkenstein, Julia; Papadamakis, Athanasios; Kleuser, Burkhard; Becker, Katrin Anne; Gulbins, Erich; Haimovitz-Friedman, Adriana; Buer, Jan; Westendorf, Astrid; Hansen, Wiebke
    Cell-intrinsic ceramides determine T cell function during melanoma progression
    In: eLife, Jg. 11, 2022, e83073
    DOI (Open Access)
  • Hoertel, Nicolas; Sánchez-Rico, Marina; Herrera-Morueco, Juan José; de la Muela, Pedro; Gulbins, Erich; Kornhuber, Johannes; Carpinteiro, Alexander; Becker-Flegler, Katrin; Cougoule, Céline; Limosin, Frédéric
    Comorbid medical conditions are a key factor to understand the relationship between psychiatric disorders and COVID-19-related mortality : Results from 49,089 COVID-19 inpatients
    In: Molecular Psychiatry, Jg. 27, 2022, Nr. 3, S. 1278 – 1280
    DOI (Open Access)
  • Becker, Katrin Anne; Verhaegh, Rabea; Verhasselt, Hedda-Luise; Keitsch, Simone; Soddemann, Matthias; Wilker, Barbara; Wilson, Gregory C.; Buer, Jan; Ahmad, Syed A.; Edwards, Michael J.; Gulbins, Erich
    Acid ceramidase rescues cystic fibrosis mice from pulmonary infections
    In: Infection and Immunity, Jg. 89, 2021, Nr. 2, S. e00677 – 20
    DOI (Open Access)
  • Beckmann, Nadine; Becker, Katrin Anne
    Ceramide and related molecules in viral infections
    In: International Journal of Molecular Sciences (IJMS), Jg. 22, 2021, Nr. 11
    DOI (Open Access)
  • Peruzzo, Roberta; Mattarei, Andrea; Azzolini, Michele; Becker-Flegler, Katrin Anne; Romio, Matteo; Rigoni, Giovanni; Carrer, Andrea; Biasutto, Lucia; Parrasia, Sofia; Kadow, Stephanie; Managò, Antonella; Urbani, Andrea; Rossa, Andrea; Semenzato, Gianpietro; Soriano, Maria Eugenia; Trentin, Livio; Ahmad, Syed; Edwards, Michael; Gulbins, Erich; Paradisi, Cristina; Zoratti, Mario; Leanza, Luigi; Szabò, Ildikò
    Corrigendum to: “Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family”
    In: Redox Biology, Jg. 45, 2021, 102036
    DOI (Open Access)
  • Becker, Katrin; Carpinteiro, Alexander; Hoffmann, Markus; Pöhlmann, Stefan; Kornhuber, Johannes; Gulbins, Erich
    Ex vivo assay to evaluate the efficacy of drugs targeting sphingolipids in preventing SARS-CoV-2 infection of nasal epithelial cells
    In: STAR Protocols, Jg. 2, 2021, Nr. 1, 100356
    DOI (Open Access)
  • Carpinteiro, Alexander; Gripp, Barbara; Hoffmann, Markus; Pöhlmann, Stefan; Hoertel, Nicolas; Edwards, Michael J.; Kamler, Markus; Kornhuber, Johannes; Becker, Katrin Anne; Gulbins, Erich
    Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells
    In: The Journal of Biological Chemistry (JBC), Jg. 296, 2021, 100701
    DOI (Open Access)
  • Váraljai, Renáta; Horn, Susanne; Sucker, Antje; Pierscianek, Daniela; Schmitt, Verena; Carpinteiro, Alexander; Becker, Katrin; Reifenberger, Julia; Rösch, Alexander; Felsberg, Joerg; Reifenberger, Guido; Sure, Ulrich; Schadendorf, Dirk; Helfrich, Iris
    Integrative genomic analyses of patient-matched intracranial and extracranial metastases reveal a novel brain-specific landscape of genetic variants in driver genes of malignant melanoma
    In: Cancers, Jg. 13, 2021, Nr. 4, S. 731
    DOI, Online Volltext (Open Access)
  • Gardner, Aaron Ions; Wu, Yuqing; Verhaegh, Rabea; Liu, Yongjie; Wilker, Barbara; Soddemann, Matthias; Keitsch, Simone; Edwards, Michael J.; Haq, Iram J.; Kamler, Markus; Becker, Katrin Anne; Brodlie, Malcolm; Gulbins, Erich
    Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis
    In: The Journal of Biological Chemistry (JBC), Jg. 296, 2021, 100650
    DOI (Open Access)
  • Hoertel, Nicolas; Sánchez-Rico, Marina; Cougoule, Céline; Gulbins, Erich; Kornhuber, Johannes; Carpinteiro, Alexander; Becker, Katrin Anne; Reiersen, Angela M.; Lenze, Eric J.; Seftel, David; Lemogne, Cédric; Limosin, Frédéric
    Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19 : Current evidence and potential mechanisms
    In: Molecular Psychiatry, Jg. 26, 2021, Nr. 12, S. 7098 – 7099
    DOI (Open Access)
  • Krones, David; Rühling, Marcel; Becker, Katrin Anne; Kunz, Tobias C.; Sehl, Carolin; Paprotka, Kerstin; Gulbins, Erich; Fraunholz, Martin
    Staphylococcus aureus α-Toxin Induces Acid Sphingomyelinase Release From a Human Endothelial Cell Line
    In: Frontiers in Microbiology, Jg. 12, 2021, 694489
    DOI (Open Access)
  • Lang, Judith; Bohn, Patrick; Bhat, Hilal; Jastrow, Holger; Walkenfort, Bernd; Cansiz, Feyza; Fink, Julian; Bauer, Michael; Olszewski, Dominik; Ramos-Nascimento, Ana; Duhan, Vikas; Friedrich, Sarah-Kim; Becker-Flegler, Katrin; Krawczyk, Adalbert; Edwards, Michael J.; Burchert, Andreas; Huber, Magdalena; Friebus-Kardash, Justa; Göthert, Joachim Rudolf; Hardt, Cornelia; Probst, Hans Christian; Schumacher, Fabian; Köhrer, Karl; Kleuser, Burkhard; Babiychuk, Eduard B.; Sodeik, Beate; Seibel, Jürgen; Greber, Urs F.; Lang, Philipp A.; Gulbins, Erich; Lang, Karl S.
    Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
    In: Nature Communications, Jg. 11, 2020, Nr. 1, S. 1338
    DOI, Online Volltext (Open Access)
  • Böll, Svenja; Ziemann, Sebastian; Ohl, Kim; Klemm, Patricia; Rieg, Annette D.; Gulbins, Erich; Becker, Katrin; Kamler, Markus; Wagner, Norbert; Uhlig, Stefan; Martin, Christian; Tenbrock, Klaus; Verjans, Eva
    Acid sphingomyelinase regulates TH2 cytokine release and bronchial asthma
    In: Allergy, Jg. 75, 2020, Nr. 3, S. 603 – 615
    DOI (Open Access)
  • Naser, Eyad; Kadow, Stephanie; Schumacher, Fabian; Mohamed, Zainelabdeen H.; Kappe, Christian; Hessler, Gabriele; Pollmeier, Barbara; Kleuser, Burkhard; Arenz, Christoph; Becker, Katrin Anne; Gulbins, Erich; Carpinteiro, Alexander
    Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro
    In: Journal of Lipid Research, Jg. 61, 2020, Nr. 6, S. 896 – 910
    DOI (Open Access)
  • Peruzzo, Roberta; Mattarei, Andrea; Azzolini, Michele; Becker-Flegler, Katrin; Romio, Matteo; Rigoni, Giovanni; Carrer, Andrea; Biasutto, Lucia; Parrasia, Sofia; Kadow, Stephanie; Managò, Antonella; Urbani, Andrea; Rossa, Andrea; Semenzato, Gianpietro; Soriano, Maria Eugenia; Trentin, Livio; Ahmad, Syed; Edwards, Michael; Gulbins, Erich; Paradisi, Cristina; Zoratti, Mario; Leanza, Luigi; Szabò, Ildikò
    Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family
    In: Redox Biology, Jg. 37, 2020, 101705
    DOI (Open Access)
  • Carpinteiro, Alexander; Edwards, Michael J.; Hoffmann, Markus; Kochs, Georg; Gripp, Barbara; Weigang, Sebastian; Adams, Constantin; Carpinteiro, Elisa; Gulbins, Anne; Keitsch, Simone; Sehl, Carolin; Soddemann, Matthias; Wilker, Barbara; Kamler, Markus; Bertsch, Thomas; Lang, Karl S.; Patel, Sameer; Wilson, Gregory C.; Walter, Silke; Hengel, Hartmut; Pöhlmann, Stefan; Lang, Philipp A.; Kornhuber, Johannes; Becker, Katrin; Ahmad, Syed A.; Fassbender, Klaus; Gulbins, Erich
    Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells
    In: Cell Reports Medicine, Jg. 1, 2020, Nr. 8, 100142
    DOI (Open Access)
  • Gardner, Aaron I.; Haq, Iram J.; Simpson, A. John; Becker, Katrin; Gallagher, John; Saint-Criq, Vinciane; Verdon, Bernard; Mavin, Emily; Trigg, Alexandra; Gray, Michael A.; Koulman, Albert; McDonnell, Melissa J.; Fisher, Andrew J.; Kramer, Elizabeth L.; Clancy, John P.; Ward, Christopher; Schuchman, Edward H.; Gulbins, Erich; Brodlie, Malcolm
    Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis
    In: American Journal of Respiratory and Critical Care Medicine (AJRCCM), Jg. 202, 2020, Nr. 8, S. 1133 – 1145
    DOI (Open Access)
  • Becker, Katrin; Uerschels, Anne-Kathrin; Goins, Laura; Doolen, Suzanne; McQuerry, Kristen J.; Bielawski, Jacek; Sure, Ulrich; Bieberich, Erhard; Taylor, Bradley K.; Gulbins, Erich; Spassieva, Stefka D.
    Role of 1-Deoxysphingolipids in docetaxel neurotoxicity
    In: Journal of Neurochemistry, Jg. 154, 2020, Nr. 6
    DOI, Online Volltext (Open Access)
  • Beck, Sascha; Sehl, Carolin; Voortmann, Sylvia; Verhasselt, Hedda Luise; Edwards, Michael J.; Buer, Jan; Hasenberg, Mike; Gulbins, Erich; Becker-Flegler, Katrin
    Sphingosine is able to prevent and eliminate Staphylococcus epidermidis biofilm formation on different orthopedic implant materials in vitro
    In: Journal of Molecular Medicine, Jg. 98, 2020, Nr. 2, S. 209 – 219
    DOI (Open Access)
  • Verhaegh, Rabea; Becker, Katrin Anne; Edwards, Michael J.; Gulbins, Erich
    Sphingosine kills bacteria by binding to cardiolipin
    In: The Journal of Biological Chemistry (JBC), Jg. 295, 2020, Nr. 22, S. 7686 – 7696
    DOI (Open Access)
  • Edwards, Michael J.; Becker, Katrin; Gripp, Barbara; Hoffmann, Markus; Keitsch, Simone; Wilker, Barbara; Soddemann, Matthias; Gulbins, Anne; Carpinteiro, Elisa; Patel, Sameer H.; Wilson, Gregory C.; Pöhlmann, Stefan; Walter, Silke; Fassbender, Klaus; Ahmad, Syed A.; Carpinteiro, Alexander; Gulbins, Erich
    Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2
    In: The Journal of Biological Chemistry (JBC), Jg. 295, 2020, Nr. 45, S. 15174 – 15182
    DOI (Open Access)
  • Beckmann, Nadine; Becker, Katrin Anne; Kadow, Stephanie; Schumacher, Fabian; Kramer, Melanie; Kühn, Claudine; Schulz-Schaeffer, Walter J.; Edwards, Michael J.; Kleuser, Burkhard; Gulbins, Erich; Carpinteiro, Alexander
    Acid sphingomyelinase deficiency ameliorates farber disease
    In: International Journal of Molecular Sciences (IJMS), Jg. 20, 2019, Nr. 24, S. 6253
    DOI (Open Access)
  • Carstens, Henning; Schumacher, Fabian; Keitsch, Simone; Kramer, Melanie; Kühn, Claudine; Sehl, Carolin; Soddemann, Matthias; Wilker, Barbara; Herrmann, Daniel; Swaidan, Ashraf; Kleuser, Burkhard; Verhaegh, Rabea; Hilken, Gero; Edwards, Michael J.; Dubicanac, Marko; Carpinteiro, Alexander; Wißmann, Andreas; Becker-Flegler, Katrin; Kamler, Markus; Gulbins, Erich
    Clinical development of sphingosine as anti-bacterial drug : Inhalation of sphingosine in mini pigs has no adverse side effects
    In: Cellular Physiology and Biochemistry, Jg. 53, 2019, Nr. 6, S. 1015 – 1028
    DOI (Open Access)
  • Bergermann, Tim; Born, Lukas; Ferguson, Fiona; Latkovic, Paula; Scheul, Alexandra; Sonnenschein, Nina; Leanza, Luigi; Keitsch, Simone; Sehl, Carolin; Wilker, Barbara; Edwards, Michael J.; Zoratti, Mario; Paradisi, Cristina; Kohnen, Markus; Szabo, Ildiko; Becker-Flegler, Katrin; Carpinteiro, Alexander
    Inhibition of PI-3-K and AKT Amplifies Kv1.3 Inhibitor-Induced Death of Human T Leukemia Cells
    In: Cellular Physiology and Biochemistry, Jg. 53, 2019, Nr. S1, S. 1 – 10
    DOI (Open Access)
  • Meiners, Jana; Palmieri, Vittoria; Klopfleisch, Robert; Ebel, Jana-Fabienne; Japtok, Lukasz; Schumacher, Fabian; Mohamud Yusuf, Ayan; Becker, Katrin A.; Zöller, Julia; Hose, Matthias; Kleuser, Burkhard; Hermann, Dirk M.; Kolesnick, Richard N.; Buer, Jan; Hansen, Wiebke; Westendorf, Astrid
    Intestinal acid sphingomyelinase protects from severe pathogen-driven colitis
    In: Frontiers in Immunology, Jg. 10, 2019, 1386
    DOI, Online Volltext (Open Access)
  • Walter, Silke; Gulbins, Erich; Halmer, Ramona; Jahromi, Neda Haghayegh; Becker-Flegler, Katrin; Schottek, Andrea; Blatti, Claudia; Davies, Laura; Schnoeder, Laura; Bertsch, Thomas; Engelhardt, Britta; Fassbender, Klaus
    Pharmacological Inhibition of Acid Sphingomyelinase Ameliorates Experimental Autoimmune Encephalomyelitis
    In: Neurosignals, Jg. 27, 2019, Nr. S1, S. 20 – 31
    DOI (Open Access)
  • Baduva, Käthe; Büchter, Lara; Kreyenkamp, Katja; Westphal, Linnea; Wilker, Barbara; Kohnen, Marcus; Schuchman, Edward H.; Edwards, Michael J.; Becker, Katrin Anne; Gulbins, Erich; Carpinteiro, Alexander
    Signalling Effects Induced by Acid Ceramidase in Human Epithelial Or Leukemic Cell Lines
    In: Cellular Physiology and Biochemistry, Jg. 52, 2019, Nr. 5, S. 1092 – 1102
    DOI (Open Access)
  • McElvaney, Oliver J.; Zaslona, Zbigniew; Becker-Flegler, Katrin; Palsson-McDermott, Eva M.; Boland, Fiona; Gunaratnam, Cedric; Gulbins, Erich; O'Neill, Luke A.; Reeves, Emer P.; McElvaney, Noel G.
    Specific inhibition of the NLRP3 inflammasome as an antiinflammatory strategy in cystic fibrosis
    In: American Journal of Respiratory and Critical Care Medicine (AJRCCM), Jg. 200, 2019, Nr. 11, S. 1381 – 1391
    DOI
  • Seitz, Aaron P.; Schumacher, Fabian; Baker, Jennifer; Soddemann, Matthias; Wilker, Barbara; Caldwell, Charles C.; Gobble, Ryan M.; Kamler, Markus; Becker-Flegler, Katrin; Beck, Sascha; Kleuser, Burkhard; Edwards, Michael J.; Gulbins, Erich
    Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia
    In: Journal of Molecular Medicine, Jg. 97, 2019, Nr. 8, S. 1195 – 1211
    DOI (Open Access)
  • Hose, Matthias; Günther, Anne; Abberger, Hanna; Begum, Salina; Korencak, Marek; Becker, Katrin A.; Buer, Jan; Westendorf, Astrid; Hansen, Wiebke
    T cell-specific overexpression of acid sphingomyelinase results in elevated T cell activation and reduced parasitemia during Plasmodium yoelii infection
    In: Frontiers in Immunology, Jg. 10, 2019, S. 1225
    DOI (Open Access)
  • Gulbins, Anne; Schumacher, Fabian; Becker, Katrin Anne; Wilker, Barbara; Soddemann, Matthias; Boldrin, Francesco; Müller, Christian P.; Edwards, Michael J.; Goodman, Michael; Caldwell, Charles C.; Kleuser, Burkhard; Kornhuber, Johannes; Szabo, Ildiko; Gulbins, Erich
    Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide
    In: Molecular Psychiatry, Jg. 23, 2018, Nr. 12, S. 2324 – 2346
    DOI (Open Access)
  • Gulbins, Anne; Schumacher, Fabian; Becker, Katrin Anne; Wilker, Barbara; Soddemann, Matthias; Boldrin, Francesco; Müller, Christian P.; Edwards, Michael J.; Goodman, Michael; Caldwell, Charles C.; Kleuser, Burkhard; Kornhuber, Johannes; Szabo, Ildiko; Gulbins, Erich
    Antidepressants regulate autophagy by targeting acid sphingomyelinase
    In: Molecular Psychiatry, Jg. 23, 2018, Nr. 12, S. 2251
    DOI
  • Becker-Flegler, Katrin; Halmer, Ramona; Davies, Laura; Henry, Brian D.; Ziobro-Henry, Regan; Decker, Yann; Liu, Yang; Gulbins, Erich; Fassbender, Klaus; Walter, Silke
    Blockade of experimental multiple sclerosis by inhibition of the acid sphingomyelinase/ceramide system
    In: Neurosignals, Jg. 25, 2018, Nr. 1, S. 88 – 97
    DOI (Open Access)
  • Carpinteiro, Alexander; Becker-Flegler, Katrin; Gulbins, Erich
    Highlight : Sphingolipids in infectious biology and immunology
    In: Biological Chemistry, Jg. 399, 2018, Nr. 10, S. 1113 – 1113
    DOI
  • Beckmann, Nadine; Kadow, Stephanie; Schumacher, Fabian; Göthert, Joachim Rudolf; Kesper, Stefanie; Draeger, Annette; Schulz-Schaeffer, Walter J.; Wang, Jiang; Becker, Jan U.; Kramer, Melanie; Kühn, Claudine; Kleuser, Burkhard; Becker-Flegler, Katrin; Gulbins, Erich; Carpinteiro, Alexander
    Pathological manifestations of Farber disease in a new mouse model
    In: Biological Chemistry, Jg. 399, 2018, Nr. 10, S. 1183 – 1202
    DOI, Online Volltext (Open Access)
  • Keitsch, Simone; Riethmüller, Joachim; Soddemann, Matthias; Sehl, Carolin; Wilker, Barbara; Edwards, Michael J.; Caldwell, Charles C.; Fraunholz, Martin; Gulbins, Erich; Becker-Flegler, Katrin
    Pulmonary infection of cystic fibrosis mice with Staphylococcus aureus requires expression of α-toxin
    In: Biological Chemistry, Jg. 399, 2018, Nr. 10, S. 1203 – 1213
    DOI
  • Becker-Flegler, Katrin; Riethmüller, Joachim; Seitz, Aaron P.; Gardner, Aaron; Boudreau, Ryan; Kamler, Markus; Kleuser, Burkhard; Schuchman, Edward; Caldwell, Charles C.; Edwards, Michael J.; Grassmé, Heike; Brodlie, Malcolm; Gulbins, Erich
    Sphingolipids as targets for inhalation treatment of cystic fibrosis
    In: Advanced Drug Delivery Reviews, Jg. 133, 2018, S. 66 – 75
    DOI
  • Becker-Flegler, Katrin; Fahsel, Björn; Kemper, Hannes; Mayeres, Joelina; Li, Cao; Wilker, Barbara; Keitsch, Simone; Soddemann, Matthias; Sehl, Carolin; Kohnen, Marcus; Edwards, Michael J.; Grassmé, Heike; Caldwell, Charles C.; Seitz, Aaron; Fraunholz, Martin; Gulbins, Erich
    Staphylococcus aureus alpha-toxin disrupts endothelial-cell tight junctions via acid sphingomyelinase and ceramide
    In: Infection and Immunity, Jg. 86, 2018, Nr. 1, S. e00606 – 17
    DOI, Online Volltext (Open Access)
  • Venturini, Elisa; Leanza, Luigi; Azzolini, Michele; Kadow, Stephanie; Mattarei, Andrea; Weller, Michael; Tabatabai, Ghazaleh; Edwards, Michael J.; Zoratti, Mario; Paradisi, Cristina; Szabò, Ildikò; Gulbins, Erich; Becker-Flegler, Katrin
    Targeting the potassium channel Kv1.3 kills glioblastoma cells
    In: Neurosignals, Jg. 25, 2018, Nr. 1, S. 26 – 38
    DOI (Open Access)
  • Chami, Marwan; Halmer, Ramona; Schnoeder, Laura; Becker, Katrin Anne; Meier, Carola; Fassbender, Klaus; Gulbins, Erich; Walter, Silke
    Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination
    In: PLoS ONE, Jg. 12, 2017, Nr. 6, S. e0178622
    DOI (Open Access)
  • Leanza, Luigi; Romio, Matteo; Becker-Flegler, Katrin; Azzolini, Michele; Trentin, Livio; Managò, Antonella; Venturini, Elisa; Zaccagnino, Angela; Mattarei, Andrea; Carraretto, Luca; Urbani, Andrea; Kadow, Stephanie; Biasutto, Lucia; Martini, Veronica; Severin, Filippo; Peruzzo, Roberta; Trimarco, Valentina; Egberts, Jan-Hendrik; Hauser, Charlotte; Visentin, Andrea; Semenzato, Gianpietro; Kalthoff, Holger; Zoratti, Mario; Gulbins, Erich; Paradisi, Cristina; Szabo, Ildiko
    Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivo
    In: Cancer Cell, Jg. 31, 2017, Nr. 4, S. 516 – 531.e10
    DOI (Open Access)
  • Kovacic, Barbara; Sehl, Carolin; Wilker, Barbara; Kamler, Markus; Becker, Katrin Anne; Gulbins, Erich
    Glucosylceramide Critically Contributes to the Host Defense of Cystic Fibrosis Lungs
    In: Cellular Physiology and Biochemistry, Jg. 41, 2017, Nr. 3, S. 1208 – 1218
    DOI (Open Access)
  • Becker-Flegler, Katrin; Beckmann, Nadine; Adams, Constantin; Hessler, Gabriele; Kramer, Melanie; Gulbins, Erich; Carpinteiro, Alexander
    Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in platelets
    In: Clinical and Experimental Metastasis, Jg. 34, 2017, Nr. 1, S. 25 – 35
    DOI
  • Becker-Flegler, Katrin; Li, Xiang; Seitz, Aaron; Steinmann, Jörg; Koch, Anne; Schuchman, Edward; Kamler, Markus; Edwards, Michael J.; Caldwell, Charles C.; Gulbins, Erich
    Neutrophils Kill Reactive Oxygen Species-Resistant Pseudomonas aeruginosa by Sphingosine
    In: Cellular Physiology and Biochemistry, Jg. 43, 2017, Nr. 4, S. 1603 – 1616
    DOI, Online Volltext (Open Access)
  • Beckmann, Nadine; Becker, Katrin Anne; Walter, Silke; Becker, Jan U.; Kramer, Melanie; Hessler, Gabriele; Weber, Stefanie; Göthert, Joachim Rudolf; Fassbender, Klaus; Gulbins, Erich; Carpinteiro, Alexander
    Regulation of Arthritis Severity by the Acid Sphingomyelinase
    In: Cellular Physiology and Biochemistry, Jg. 43, 2017, Nr. 4, S. 1460 – 1471
    DOI (Open Access)
  • Martin, Grace E.; Boudreau, Ryan M.; Couch, Caroline; Becker-Flegler, Katrin; Edwards, Michael J.; Caldwell, Charles C.; Gulbins, Erich; Seitz, Aaron
    Sphingosine's role in epithelial host defense : a natural antimicrobial and novel therapeutic
    In: Biochimie, Jg. 141, 2017, S. 91 – 96
    DOI
  • Ma, Jie; Gulbins, Erich; Edwards, Michael J.; Caldwell, Charles C.; Fraunholz, Martin; Becker-Flegler, Katrin
    Staphylococcus aureus α-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Ceramides
    In: Cellular Physiology and Biochemistry, Jg. 43, 2017, Nr. 6, S. 2170 – 2184
    DOI (Open Access)
  • Collenburg, Lena; Beyersdorf, Niklas; Wiese, Teresa; Arenz, Christoph; Saied, Essa M.; Becker-Flegler, Katrin; Schneider-Schaulies, Sibylle; Avota, Elita
    The activity of the neutral sphingomyelinase is important in T cell recruitment and directional migration
    In: Frontiers in Immunology, Jg. 8, 2017, S. 1007
    DOI (Open Access)
  • Grassmé, Heike; Henry, Brian; Ziobro, Regan; Becker, Katrin Anne; Riethmüller, Joachim; Gardner, Aaron; Seitz, Aaron P.; Steinmann, Jörg; Lang, Stephan; Ward, Christopher; Schuchman, Edward H.; Caldwell, Charles C.; Kamler, Markus; Edwards, Michael J.; Brodlie, Malcolm; Gulbins, Erich
    β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections
    In: Cell Host & Microbe, Jg. 21, 2017, Nr. 6, S. 707 – 718.e8
    DOI, Online Volltext (Open Access)
  • Hollmann, Claudia; Werner, Sandra; Avota, Elita; Reuter, Dajana; Japtok, Lukasz; Kleuser, Burkhard; Gulbins, Erich; Becker-Flegler, Katrin; Schneider-Schaulies, Jürgen; Beyersdorf, Niklas
    Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+ Conventional versus Foxp3+ Regulatory T Cells
    In: The Journal of Immunology (JI), Jg. 197, 2016, Nr. 8, S. 3130 – 3141
    DOI (Open Access)
  • Tavakoli Tabazavareh, Shaghayegh; Seitz, Aaron P.; Jernigan, Peter L.; Sehl, Carolin; Keitsch, Simone; Lang, Stephan; Kahl, Barbara C.; Edwards, Michael John Richard; Grassmé, Heike; Gulbins, Erich; Becker-Flegler, Katrin
    Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic Fibrosis
    In: Cellular Physiology and Biochemistry, Jg. 38, 2016, Nr. 6, S. 2094 – 2102
    DOI (Open Access)
  • Carpinteiro, Alexander; Beckmann, Nadine; Seitz, Aaron; Hessler, Gabriele; Wilker, Barbara; Soddemann, Matthias; Helfrich, Iris; Edelmann, Bärbel; Gulbins, Erich; Becker, Katrin Anne
    Role of Acid Sphingomyelinase-Induced Signaling in Melanoma Cells for Hematogenous Tumor Metastasis
    In: Cellular Physiology and Biochemistry, Jg. 38, 2016, Nr. 1, S. 1 – 14
    DOI (Open Access)
  • Gulbins, Erich; Walter, Silke; Becker-Flegler, Katrin; Halmer, Ramona; Liu, Yang; Reichel, Martin; Edwards, Michael J; Müller, Christian P; Fassbender, Klaus; Kornhuber, Johannes
    A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression
    In: Journal of Neurochemistry, Jg. 134, 2015, Nr. 2, S. 183 – 192
    DOI
  • Henry, Brian D; Babiychuk, Eduard B; Draeger, Annette; Kadioglu, Aras; Gulbins, Erich; Scherag, Andre; Wolfmeier, Heidi; Luginbühl, Miriam; Japtok, Lukasz; Kleuser, Burkhard; Steinmann, Jörg; Mühlemann, Kathrin; Edwards, Michael J; Ziobro, Regan; Bricio-Moreno, Laura; Gore, Suzanna; Becker-Flegler, Katrin; Neill, Daniel R
    Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice
    In: Nature Biotechnology, Jg. 33, 2015, Nr. 1, S. 81 – 88
    DOI
  • Hajj, Carla; Becker-Flegler, Katrin; Haimovitz-Friedman, Adriana
    Novel mechanisms of action of classical chemotherapeutic agents on sphingolipid pathways
    In: Biological Chemistry, Jg. 396, 2015, Nr. 6-7, S. 669 – 679
    DOI
  • Managò, Antonella; Becker-Flegler, Katrin; Carpinteiro, Alexander; Wilker, Barbara; Soddemann, Matthias; Seitz, Aaron P.; Edwards, Michael John Richard; Grassmé, Heike; Szabò, Ildikò M.; Gulbins, Erich
    Pseudomonas aeruginosa Pyocyanin Induces Neutrophil Death via Mitochondrial Reactive Oxygen Species and Mitochondrial Acid Sphingomyelinase
    In: Antioxidants and Redox Signaling, Jg. 22, 2015, Nr. 13, S. 1097 – 1110
    DOI (Open Access)
  • Carpinteiro, Alexander; Becker-Flegler, Katrin; Japtok, Lukasz; Hessler, Gabriele; Keitsch, Simone; Požgajovà, Miroslava; Schmid, Kurt Werner; Adams, Constantin; Müller, Stefan; Kleuser, Burkhard; Edwards, Michael J.; Grassmé, Heike; Helfrich, Iris; Gulbins, Erich
    Regulation of hematogenous tumor metastasis by acid sphingomyelinase
    In: EMBO Molecular Medicine, Jg. 7, 2015, Nr. 6, S. 714 – 734
    DOI (Open Access)
  • Beckmann, N.; Sharma, D.; Gulbins, Erich; Becker-Flegler, Katrin; Edelmann, Bärbel
    Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons
    In: Frontiers in Physiology, 2014, Nr. 5, S. 331
    DOI (Open Access)
  • Siegmann, Nanna; Worbs, David; Effinger, Frauke; Bormann, Tobias; Gebhardt, Madlen; Ulrich, Martina; Wermeling, Fredrik; Müller-Hermelink, Eva; Biedermann, Tilo; Tighe, Mike; Edwards, Michael J; Caldwell, Charles; Leadbetter, Elizabeth; Karlsson, Mikael C I; Becker-Flegler, Katrin; Gulbins, Erich; Döring, Gerd
    Invariant natural killer T (iNKT) cells prevent autoimmunity, but induce pulmonary inflammation in cystic fibrosis
    In: Cellular Physiology and Biochemistry, Jg. 34, 2014, Nr. 1, S. 56 – 70
    DOI (Open Access)
  • Grassmé, Heike; Carpinteiro, Alexander; Edwards, Michael J; Gulbins, Erich; Becker-Flegler, Katrin
    Regulation of the inflammasome by ceramide in cystic fibrosis lungs
    In: Cellular Physiology and Biochemistry, Jg. 34, 2014, Nr. 1, S. 45 – 55
    DOI (Open Access)
  • Gulbins, Erich; Palmada, Monica; Reichel, Martin; Lüth, Anja; Böhmer, Christoph; Amato, Davide; Müller, Christian P.; Tischbirek, Carsten H.; Groemer, Teja W.; Tabatabai, Ghazaleh; Becker-Flegler, Katrin; Tripal, Philipp; Staedtler, Sven; Ackermann, Teresa F.; Van Brederode, Johannes; Alzheimer, Christian; Weller, Michael; Lang, Undine E.; Kleuser, Burkhard; Grassmé, Heike; Kornhuber, Johannes
    Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs
    In: Nature Medicine, Jg. 19, 2013, Nr. 7, S. 934 – 938
    DOI
  • Leanza, L; Trentin, L; Becker-Flegler, Katrin; Frezzato, F; Zoratti, M; Semenzato, G; Gulbins, Erich; Szabo, I
    Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia
    In: Leukemia, Jg. 27, 2013, Nr. 8, S. 1782 – 1785
    DOI
  • Gramatzki, Dorothee; Herrmann, Caroline; Happold, Caroline; Becker, Katrin Anne; Gulbins, Erich; Weller, Michael; Tabatabai, Ghazaleh
    Glioma Cell Death Induced by Irradiation or Alkylating Agent Chemotherapy Is Independent of the Intrinsic Ceramide Pathway
    In: PLoS ONE, Jg. 8, 2013, Nr. 5, S. e63527
    DOI (Open Access)
  • Henry, Brian; Möller, Christina; Dimanche-Boitrel, Marie-Therese; Gulbins, Erich; Becker, Katrin Anne
    Targeting the ceramide system in cancer
    In: Cancer Letters, Jg. 332, 2013, Nr. 2, S. 286 – 294
    DOI
  • Grassmé, Heike; Becker, Katrin; Gulbins, Erich
    Wirkungsvolle Lipide : Sphingolipide, bakterielle Infektionen und zystische Fibrose
    In: Unikate: Berichte aus Forschung und Lehre, 2013, Nr. 44: Medizin: 50 Jahre Universitätsklinikum Essen, S. 22 – 31
    DOI, Online Volltext (Open Access)
  • Becker-Flegler, Katrin; Henry, Brian; Ziobro, Regan; Tümmler, Burkhard; Gulbins, Erich; Grassmé, Heike
    Role of CD95 in pulmonary inflammation and infection in cystic fibrosis
    In: Journal of Molecular Medicine, Jg. 90, 2012, Nr. 9, S. 1011 – 1023
    DOI
  • Becker-Flegler, Katrin; Henry, Brian; Ziobro, Regan; Riethmüller, Joachim; Gulbins, Erich
    Lipids in cystic fibrosis
    In: Expert Review of Respiratory Medicine, Jg. 5, 2011, Nr. 4, S. 527 – 535
    DOI
  • Braun, N.; Duebbers, A.; Kuester, P.; Ellemunter, H.; Heuer, E.; Sextro, W.; Junge, S.; Tuemmler, B.; Mellies, Uwe; Teschler, Helmut; Mainz, J. G.; Riethmueller, J.; Graepler-Mainka, U.; Koerner-Rettberg, C.; Ballmann, M.; Szczepanski, R.; Wald, A.; Wisbauer, M.; Adelsberger, D.; Staab, D.; Wollschlager, B.; Hammermann, J.; Peters, G.; Becker-Flegler, Katrin; Kahl, B. C.
    Molecular Analysis of Staphylococcus Aureus Isolates from an Ongoing Prospective Observational Longitudinal Multicenter Study Determining Staphylococcus Aureus Airway Colonization or Infection in Cystic Fibrosis Patients
    In: Pediatric Pulmonology, Jg. 34, 2011, S. 323 – 323
    DOI
  • Becker, Katrin Anne; Tümmler, Burkhard; Gulbins, Erich; Grassmé, Heike
    Accumulation of ceramide in the trachea and intestine of cystic fibrosis mice causes inflammation and cell death
    In: Biochemical and Biophysical Research Communications (BBRC), Jg. 403, 2010, Nr. 3-4, S. 368 – 374
    DOI
  • Becker-Flegler, Katrin; Riethmüller, Joachim; Lüth, Anja; Döring, Gerd; Kleuser, Burkhard; Gulbins, Erich
    Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis
    In: American Journal of Respiratory Cell and Molecular Biology, Jg. 42, 2010, Nr. 6, S. 716 – 724
    DOI
  • Grassmé, Heike; Becker-Flegler, Katrin; Zhang, Yang; Gulbins, Erich
    CFTR-dependent susceptibility of the cystic fibrosis-host to Pseudomonas aeruginosa
    In: International Journal of Medical Microbiology (IJMM), Jg. 300, 2010, Nr. 8, S. 578 – 583
    DOI
  • Becker, Katrin Anne; Grassmé, Heike; Zhang, Yang; Gulbins, Erich
    Ceramide in pseudomonas aeruginosa infections and cystic fibrosis
    In: Cellular Physiology and Biochemistry, Jg. 26, 2010, Nr. 1, S. 57 – 66
    DOI (Open Access)
  • Li, Xiang; Becker, Katrin Anne; Zhang, Yang
    Ceramide in redox signaling and cardiovascular diseases
    In: Cellular Physiology and Biochemistry, Jg. 26, 2010, Nr. 1, S. 41 – 48
    DOI (Open Access)
  • Becker, Katrin Anne; Riethmüller, Joachim; Zhang, Yang; Gulbins, Erich
    The Role of Sphingolipids and Ceramide in Pulmonary Inflammation in Cystic Fibrosis
    In: Open Respiratory Medicine Journal, Jg. 4, 2010, S. 39 – 47
    DOI

    • Abstracts

  • Hoertel, N.; Sanchez-Rico, Marina; Kornhuber, J.; Gulbins, Erich; Reiersen, A.; Lenze, E.; Fritz, B. A.; Jalali, F.; Mills, E.; Cougoule, C.; Carpinteiro, Alexander; Mühle, C.; Becker-Flegler, Katrin A.; Boulware, D. R.; Blanco, C.; Alvarado, J. M.; Strub-Wourgaft, N.; Lemogne, C.; Limosin, F.
    Antidepressant Use and Its Association with 28-Day Mortality in Inpatients with SARS-CoV-2 : Support for the FIASMA Model against COVID-19
    31st European Congress of Psychiatry, EPA 2023, 25-28 March 2023, Paris, France,
    In: European Psychiatry. Cambridge: Cambridge University Press, Jg. 66, 2023, Nr. S1, S. S118 – S119
    DOI (Open Access)
  • Becker, Katrin; Jaegers, J.; Fandrey, Joachim; Gulbins, Erich; Ferenz, Katja
    Development of sphingosine-coupled oxygen carriers as novel drugs for treating pneumonia
    98th Meeting of the German Physiological Society, 30 September ‐ 2 October 2019, Ulm, Germany,
    In: Acta Physiologica. Weinheim: Wiley-Blackwell, Jg. 227, 2019, Nr. S719, B 04-10
    Online Volltext

    • Beiträge in Sammelwerken und Tagungsbänden

  • Becker, Katrin; Gulbins, Erich
    Ceramide
    In: Encyclopedia of Cancer / Schwab, Manfred (Hrsg.). Berlin: Springer Berlin Heidelberg, 2014, S. 906 – 908
    DOI (Open Access)
  • Henry, Brian; Ziobro, Regan; Becker, Katrin Anne; Kolesnick, Richard; Gulbins, Erich
    Acid Sphingomyelinase
    In: Sphingolipids: Basic Science and Drug Development / Gulbins, Erich; Petrache, Irena. Heidelberg [u.a.]: Springer, 2013, S. 77 – 88
    DOI
  • Grassmé, Heike; Becker, Katrin Anne
    Bacterial infections and ceramide
    In: Sphingolipids in Disease / Gulbins, Erich; Petrache, Irina. Wien [u.a.]: Springer, 2013, S. 305 – 320
    DOI

    • Bücher/Sammelwerke/Tagungsbände

  • Becker-Flegler, Katrin
    Rolle vonSphingolipidenbei Entzündungen und Infektionen
    Duisburg ; Essen, 2017