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Klinik für Endokrinologie am Universitätsklinikum Essen
Anschrift
Hufelandstraße 55
45122 Essen
45122 Essen
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Funktionen
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apl. Professor/in und Privatdozent/in, Klinik für Endokrinologie
Aktuelle Veranstaltungen
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SoSe 2025
- Pathophysiologie (WA)
- Wahlfach Klinische Endokrinologie und Diabetologie
- Neurochirurgisch-endokrinologische Konferenz / Endokrines Tumorzentrum am WTZ
- Wahlfach Molekulare Endokrinologie (*)
- Kolloquium Endokrinologie und Stoffwechsel (*)
- Innere Medizin Vorlesung, Teil 1 (WA)
- Kurs der allgemeinen klinischen Untersuchungen (PV)
- Endokrines Tumorzentrum am WTZ und ENETS-Center of Excellence
- Klinische Chemie, Laboratoriumsdiagnostik (WA)
- Differentialdiagnose Innere Krankheiten
- Blockpraktikum Innere Medizin (PV)
- Innere Medizin für Studierende im Praktischen Jahr (*)
- Wiss. Arbeiten, Klinik für Endokrinologie, Diabetologie und Stoffwechsel
- Klinische Visite Endokrinologie und Stoffwechsel
- Seminare für Doktoranden in der Endokrinologie und Diabetologie
Vergangene Veranstaltungen (max. 10)
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WiSe 2024
- Wahlfach Molekulare Endokrinologie (*)
- Wahlfach Klinische Endokrinologie und Diabetologie
- Neurochirurgisch-endokrinologische Konferenz / Endokrines Tumorzentrum am WTZ
- Kurs der allgemeinen klinischen Untersuchungen (PV)
- Endokrines Tumorzentrum am WTZ und ENETS-Center of Excellence
- Pathophysiologie (WA)
- Kolloquium Endokrinologie und Stoffwechsel (*)
- Seminare für Doktoranden in der Endokrinologie und Diabetologie
- Klinische Chemie, Laboratoriumsdiagnostik (WA)
- Differentialdiagnose Innere Krankheiten
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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msiFlow : automated workflows for reproducible and scalable multimodal mass spectrometry imaging and microscopy data analysisIn: Nature Communications , Jg. 16 2025, Nr. 1, 1065DOI (Open Access)
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Canonical and Noncanonical Contribution of Thyroid Hormone Receptor Isoforms Alpha and Beta to Cardiac Hypertrophy and Heart Rate in Male MiceIn: Thyroid , Jg. 34 2024, Nr. 6, S. 785 – 795DOI, Online Volltext (Open Access)
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Cardiac recovery from pressure overload is not altered by thyroid hormone status in old miceIn: Frontiers in Endocrinology , Jg. 15 2024, 1339741DOI (Open Access)
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Comparative Phenotyping of Mice Reveals Canonical and Noncanonical Physiological Functions of TRα and TRβIn: Endocrinology , Jg. 165 2024, Nr. 8, bqae067DOI (Open Access)
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Generation of THRB-GS(E125G_G126S) and THRB-KO human iPSC lines to study noncanonical thyroid hormone signallingIn: Stem Cell Research , Jg. 74 2024, 103275DOI (Open Access)
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Lack of canonical thyroid hormone receptor α signaling changes regulatory T cell phenotype in female miceIn: iScience , Jg. 27 2024, Nr. 8, 110547DOI (Open Access)
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Partial Resistance to Thyroid Hormone-Induced Tachycardia and Cardiac Hypertrophy in Mice Lacking Thyroid Hormone Receptor βIn: Thyroid , Jg. 34 2024, Nr. 6, S. 796 – 805DOI, Online Volltext (Open Access)
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Aktuelle Therapieansätze der endokrinen Orbitopathie - sind die zielgerichteten Therapien die Zukunft?In: Klinische Monatsblätter für Augenheilkunde , Jg. 241 2023, Nr. 1, S. 48 – 68
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Endokrine Orbitopathie : Aktueller Stand der medikamentösen TherapieIn: Laryngo-Rhino-Otologie , Jg. 102 2023, Nr. 3, S. 177 – 185
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Evolution of non-thyroidal illness syndrome in acute decompensation of liver cirrhosis and acute-on-chronic liver failureIn: Frontiers in Endocrinology , Jg. 14 2023, 1104388DOI (Open Access)
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Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profileIn: Frontiers in Immunology , Jg. 14 2023, 1192057DOI, Online Volltext (Open Access)
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Thyroid hormone receptor alpha modulates fibrogenesis in hepatic stellate cellsIn: Liver International 2023 , in pressDOI (Open Access)
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Thyroid hormones regulate Zfp423 expression in regionally distinct adipose depots through direct and cell-autonomous actionIn: Cell Reports , Jg. 42 2023, Nr. 2, 112088DOI (Open Access)
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Translational perspectives from TSHR, MCT8 and TRα researchIn: Nature Reviews Endocrinology , Jg. 19 2023, Nr. 2, S. 74 – 75
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Canonical Thyroid Hormone Receptor β Action Stimulates Hepatocyte Proliferation in Male MiceIn: Endocrinology , Jg. 163 2022, Nr. 3, bqac003DOI (Open Access)
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Cardioprotection by Hypothyroidism Is Not Mediated by Favorable Hemodynamics : Role of Canonical Thyroid Hormone Receptor Alpha SignalingIn: International Journal of Molecular Sciences (IJMS) , Jg. 23 2022, Nr. 21, 13340DOI, Online Volltext (Open Access)
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Cell-Specific Transport and Thyroid Hormone Receptor Isoform Selectivity Account for Hepatocyte-Targeted Thyromimetic Action of MGL-3196In: International Journal of Molecular Sciences (IJMS) , Jg. 23 2022, Nr. 22, 13714DOI, Online Volltext (Open Access)
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The interplay of thyroid hormones and the immune system : where we stand and why we need to know about itIn: European Journal of Endocrinology (EJE) , Jg. 168 2022, Nr. 5, S. R65 – R77DOI (Open Access)
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A Novel Double RET E768D/L790F Mutation Associated with a MEN2B-Like PhenotypeIn: Thyroid , Jg. 31 2021, Nr. 2, S. 327 – 329
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Age-dependent response to T4 overtreatment and recovery on systemic and organ levelIn: Journal of Molecular Endocrinology , Jg. 67 2021, Nr. 4, S. 161 – 172DOI (Open Access)
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Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism : A Consensus DocumentIn: Thyroid , Jg. 31 2021, Nr. 2, S. 156 – 182DOI (Open Access)
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Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus DocumentIn: European Thyroid Journal , Jg. 10 2021, Nr. 1, S. 10 – 38DOI (Open Access)
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Graves' orbitopathy : Current concepts for medical treatmentIn: Klinische Monatsblätter für Augenheilkunde , Jg. 238 2021, Nr. 1, S. 24 – 31
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Graves' orbitopathyIn: Deutsche Medizinische Wochenschrift - DMW , Jg. 146 2021, Nr. 20, S. 1344 – 1351
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Noncanonical Thyroid Hormone Receptor α Action Mediates Arterial VasodilationIn: Endocrinology , Jg. 162 2021, Nr. 7, bqab099DOI (Open Access)
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Predicting the Course of Graves’ Orbitopathy Using Serially Measured TSH-Receptor Autoantibodies by Automated Binding Immunoassays and the Functional BioassayIn: Hormone and Metabolic Research , Jg. 53 2021, Nr. 07, S. 435 – 443DOI (Open Access)
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Predicting the Relapse of Hyperthyroidism in Treated Graves’ Disease with Orbitopathy by Serial Measurements of TSH-Receptor AutoantibodiesIn: Hormone and Metabolic Research , Jg. 53 2021, Nr. 4, S. 235 – 244DOI (Open Access)
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Protective Effects of Thyroid Hormone Deprivation on Progression of Maladaptive Cardiac Hypertrophy and Heart FailureIn: Frontiers in Cardiovascular Medicine , Jg. 8 2021, 683522DOI, Online Volltext (Open Access)
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Asymmetry indicates more severe and active disease in Graves’ orbitopathy : results from a prospective cross-sectional multicentre studyIn: Journal of Endocrinological Investigation , Jg. 43 2020, Nr. 12, S. 1717 – 1722DOI (Open Access)
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Noncanonical Action of Thyroid Hormone Receptors α and βIn: Experimental and Clinical Endocrinology & Diabetes , Jg. 128 2020, Nr. 6-7, S. 383 – 387
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Aging alters phenotypic traits of thyroid dysfunction in male mice with divergent effects on complex systems but preserved thyroid hormone action in target organsIn: Journals of Gerontology Series A: Biological Sciences and Medical Sciences , Jg. 74 2019, Nr. 8, S. 1162 – 1169
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Aging is associated with low thyroid state and organ-specific sensitivity to thyroxineIn: Thyroid , Jg. 29 2019, Nr. 12, S. 1723 – 1733DOI (Open Access)
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Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in MiceIn: Thyroid , Jg. 29 2019, Nr. 10, S. 1438 – 1446DOI (Open Access)
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Low Free Triiodothyronine Is Associated with Advanced Fibrosis in Patients at High Risk for Nonalcoholic SteatohepatitisIn: Digestive Diseases and Sciences , Jg. 64 2019, Nr. 8, S. 2351 – 2358
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Thyroid Related Quality of Life in Elderly with Subclinical Hypothyroidism and Improvement on Levothyroxine is Distinct from that in Young Patients (TSAGE)In: Hormone and Metabolic Research , Jg. 51 2019, Nr. 9, S. 568 – 574
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Thyroxine promotes lung cancer growth in an orthotopic mouse modelIn: Endocrine-Related Cancer , Jg. 26 2019, Nr. 6, S. 565 – 574DOI (Open Access)
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Assessment and Management of Anti-Insulin Autoantibodies in Varying Presentations of Insulin Autoimmune SyndromeIn: The Journal of Clinical Endocrinology & Metabolism (JCEM) , Jg. 103 2018, Nr. 10, S. 3845 – 3855DOI (Open Access)
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Graves’ orbitopathy occurs sex-independently in an autoimmune hyperthyroid mouse modelIn: Scientific Reports , Jg. 8 2018, S. 13096DOI, Online Volltext (Open Access)
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Mycophenolate plus methylprednisolone versus methylprednisolone alone in active, moderate-to-severe Graves' orbitopathy (MINGO) : a randomised, observer-masked, multicentre trialIn: The Lancet Diabetes and Endocrinology , Jg. 6 2018, Nr. 4, S. 287 – 298
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A Novel Mutation in the TBG Gene Producing Partial Thyroxine-Binding Globulin Deficiency (Glencoe) Identified in 2 Families.In: European Thyroid Journal , Jg. 6 2017, Nr. 3, S. 138 – 142DOI (Open Access)
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Clinical Characterization of the Pheochromocytoma and Paraganglioma Susceptibility Genes SDHA, TMEM127, MAX, and SDHAF2 for Gene-Informed PreventionIn: JAMA Oncology , Jg. 3 2017, Nr. 9, S. 1204 – 1212DOI (Open Access)
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Differential regulation of monocarboxylate transporter 8 expression in thyroid cancer and hyperthyroidismIn: European Journal of Endocrinology (EJE) , Jg. 177 2017, Nr. 3, S. 243 – 250
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Fetal Exposure to High Maternal Thyroid Hormone Levels Causes Central Resistance to Thyroid Hormone in Adult Humans and MiceIn: The Journal of Clinical Endocrinology & Metabolism (JCEM) , Jg. 102 2017, Nr. 9, S. 3234 – 3240
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NGS based identification of mutational hotspots for targeted therapy in anaplastic thyroid carcinomaIn: OncoTarget , Jg. 8 2017, Nr. 26, S. 42613 – 42620DOI (Open Access)
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Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivoIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Jg. 114 2017, Nr. 52, S. E11323 – E11332
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Pituitary apoplexy – A single center retrospective study from the neurosurgical perspective and review of the literatureIn: Clinical Neurology and Neurosurgery , Jg. 163 2017, S. 39 – 45
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Plasma cortisol response cannot be classically conditioned in a taste-endocrine paradigm in humansIn: Psychopharmacology , Jg. 234 2017, Nr. 21, S. 3249 – 3257
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Salivary alpha-amylase and noradrenaline responses to corticotropin-releasing hormone administration in humansIn: Biological Psychology , Jg. 127 2017, S. 34 – 39
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Sex-specific phenotypes of hyperthyroidism and hypothyroidism in aged miceIn: Biology of Sex Differences , Jg. 8 2017, S. 38DOI (Open Access)
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Thyroid hormone signaling pathways : Time for a more precise nomenclatureIn: Endocrinology , Jg. 158 2017, Nr. 7, S. 2052 – 2057
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A 6-Base Pair in Frame Germline Deletion in Exon 7 Of RET Leads to Increased RET Phosphorylation, ERK Activation, and MEN2AIn: The Journal of Clinical Endocrinology & Metabolism (JCEM) , Jg. 101 2016, Nr. 3, S. 1016 – 1022DOI (Open Access)
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Efficacy of protocols for induction of chronic hyperthyroidism in male and female miceIn: Endocrine , Jg. 54 2016, Nr. 1, S. 47 – 54
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Sex-specific phenotypes of hyperthyroidism and hypothyroidism in miceIn: Biology of Sex Differences , Jg. 7 2016, Nr. 1, S. 36DOI (Open Access)
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Targeted next-generation sequencing for TP53, RAS, BRAF, ALK and NF1 mutations in anaplastic thyroid cancerIn: Endocrine , Jg. 54 2016, Nr. 3, S. 733 – 741
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The long N-terminus of the human monocarboxylate transporter 8 is a target of ubiquitin-dependent proteasomal degradation which regulates protein expression and oligomerization capacityIn: Molecular and Cellular Endocrinology , Jg. 434 2016, S. 278 – 287
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A novel mechanism of inherited TBG deficiency : mutation in a liverspecific enhancerIn: The Journal of Clinical Endocrinology & Metabolism (JCEM) , Jg. 100 2015, Nr. 1, S. E173 – E181
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Artificial Hyperparathyroidism : Think Twice Before Taking Your Blood SampleIn: The American Journal of Medicine , Jg. 128 2015, Nr. 12, S. 21 – 22
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Differences in Mouse Hepatic Thyroid Hormone Transporter Expression with Age and HyperthyroidismIn: European Thyroid Journal , Jg. 4 2015, Nr. Suppl 1, S. 81 – 86
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Higher Thyroid-Stimulating Hormone, Triiodothyronine and Thyroxine Values Are Associated with Better Outcome in Acute Liver FailureIn: PLoS ONE , Jg. 10 2015, Nr. 7, S. 0132189DOI (Open Access)
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Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutationsIn: Journal of Molecular Endocrinology , Jg. 54 2015, Nr. 1, S. 39 – 50DOI (Open Access)
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PREGO (presentation of Graves’ orbitopathy) study : changes in referral patterns to European Group On Graves’ Orbitopathy (EUGOGO) centres over the period from 2000 to 2012In: British Journal of Ophthalmology (BJO) , Jg. 99 2015, Nr. 11, S. 1531 – 1535
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Sex-Dependent Claudin-1 Expression in the Liver of Euthyroid and Hypothyroid MiceIn: European Thyroid Journal , Jg. 4 2015, Nr. Suppl 1, S. 67 – 73
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Successful treatment of type B insulin resistance with rituximabIn: The Journal of Clinical Endocrinology & Metabolism (JCEM) , Jg. 100 2015, Nr. 5, S. 1719 – 1722DOI (Open Access)
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The Effects of Thyroid Hormones on Gene Expression of Acyl-Coenzyme A Thioesterases in Adipose Tissue and Liver of MiceIn: European Thyroid Journal , Jg. 4 2015, Nr. Suppl 1, S. 59 – 66
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The impact of CLAUDIN-1 on follicular thyroid carcinoma aggressivenessIn: Endocrine-Related Cancer , Jg. 22 2015, Nr. 5, S. 819 – 830DOI (Open Access)
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Two Novel Mutations in the Serpina7 Gene Are Associated with Complete Deficiency of Thyroxine-Binding GlobulinIn: European Thyroid Journal , Jg. 4 2015, Nr. Suppl 1, S. 108 – 112
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A case of extreme insulin resistance due to high levels of insulin receptor autoantibodies (type B insulin resistance)In: Experimental and Clinical Endocrinology & Diabetes , Jg. 122 2014, Nr. 3, S. P001
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Aggressive treatment of a 51 year old patient with anaplastic thyroid cancer with over one year survivalIn: Experimental and Clinical Endocrinology & Diabetes , Jg. 122 2014, Nr. 3, S. P025
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Comparison of two protocols for induction of hyperthyroidism in miceIn: Experimental and Clinical Endocrinology & Diabetes , Jg. 122 2014, Nr. 3, S. P152
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Expression profiles of thyroid hormone transporters Mct10 and Lat2 within the different intestinal segments of young and aged wild-type miceIn: Experimental and Clinical Endocrinology & Diabetes , Jg. 122 2014, Nr. 3, S. P088
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In quest of oral thyroxine resistance - three case reports with assumed intestinal malabsorption of levothyroxineIn: Experimental and Clinical Endocrinology & Diabetes , Jg. 122 2014, Nr. 3, S. P090
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Investigation of potential effects on thyroglobulin processing enzymes and thyroid hormone transporters in thyroid glands of mice with induced hypo- or hyperthyroidismIn: Experimental and Clinical Endocrinology & Diabetes , Jg. 122 2014, Nr. 3, S. P150
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Long-term prognosis of patients with pediatric pheochromocytomaIn: Endocrine-Related Cancer , Jg. 21 2014, Nr. 1, S. 17 – 25DOI (Open Access)
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Protocols for induction of hypothyroidism in mice validated by gene expression in liver and heartIn: Experimental and Clinical Endocrinology & Diabetes , Jg. 122 2014, Nr. 3, S. P143
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Successful Treatment of a Patient with Extreme Insulin Resistance Due to High Levels of Insulin Receptor Autoantibodies (Type B Insulin Resistance) with RituximabIn: Endocrine Reviews , Jg. 35 2014, Nr. 3 Suppl.
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Diabetes insipidus as a rare cause of acute cognitive impairment in multiple sclerosisIn: Multiple Sclerosis Journal , Jg. 19 2013, Nr. 12, S. 1676 – 1678
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Diabetes insipidus as a rare cause of cognitive impairment in multiple sclerosisIn: Experimental and Clinical Endocrinology & Diabetes , Jg. 121 2013, S. P43
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Ectopic Cushing's syndrome caused by ACTH-secreting non-functioning pheochromocytomaIn: Experimental and Clinical Endocrinology & Diabetes , Jg. 121 2013, S. P32
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Prevalence of thyroid dysfunction and age dependency of TSH in a population-based study : Results from the Heinz Nixdorf Recall Study (HNR)In: Experimental and Clinical Endocrinology & Diabetes , Jg. 121 2013, Nr. 3, S. P16
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Thyroid hormone, thyroid hormone receptors, and cancer : a clinical perspectiveIn: Endocrine-Related Cancer , Jg. 20 2013, Nr. 2, S. R19 – R29
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Germline Mutations of theTMEM127Gene in Patients with Paraganglioma of Head and Neck and Extraadrenal Abdominal SitesIn: The Journal of Clinical Endocrinology & Metabolism (JCEM) , Jg. 96 2011, Nr. 8, S. E1279 – E1282
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Novel SDHD Gene Mutation (H102R) in a Patient With Metastatic Cervical Paraganglioma Effectively Treated by Peptide Receptor Radionuclide TherapyIn: Journal of Clinical Oncology (JCO) , Jg. 29 2011, Nr. 33
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Stanniocalcin 1 Induction by Thyroid Hormone Depends on Thyroid Hormone Receptor β and Phosphatidylinositol 3-kinase ActivationIn: Experimental and Clinical Endocrinology & Diabetes , Jg. 119 2011, Nr. 2, S. 81 – 85DOI (Open Access)
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Transcriptional regulation by nonclassical action of thyroid hormoneIn: Thyroid Research , Jg. 4 2011, Nr. Suppl. 1, S. 1 – 7DOI, Online Volltext (Open Access)
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Treatment of Advanced Medullary Thyroid Carcinoma with a Combination of Cyclophosphamide, Vincristine, and Dacarbazine : a Single-Center ExperienceIn: Experimental and Clinical Endocrinology & Diabetes , Jg. 119 2011, Nr. 9, S. 540 – 543
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Combined PER2 and CRY1 expression predicts outcome in chronic lymphocytic leukemiaIn: European Journal of Haematology , Jg. 83 2009, Nr. 4, S. 320 – 327
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Absence of cholesterol gallstone formation in male C57BL/6 mice by abrogation of hepatic thyroid hormone actionIn: Journal of Hepatology , Jg. 82 2025, S. 279
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Higher thyroid-stimulating hormone, triiodothyronine and thyroxine values are associated with better outcome in acute liver failureIn: Hepatology , Jg. 60 2014, Nr. Suppl. 1, S. 556A – 557A
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Molecular mechanisms of sex-dependent thyroid hormone action on target tissues
57th Symposium of the German Society of Endocrinology (DGE) ; 19th–22th March, 2014, Dresden, Germany,In: Experimental and Clinical Endocrinology & Diabetes , Jg. 122 2014, Nr. 3, S. P145 -
Principles of Hormone ActionIn: Williams Textbook of Endocrinology / Melmed, Shlomo; Auchus, Richard J.; Goldfine, Allison B.; Rosen, Clifford J.; Kopp, Peter A. (Hrsg.) 2025, S. 13.e4 – 42.e4
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Tier- und zellexperimentelle Untersuchungen zu Regulation, Transport und neuen Wirkungsmechanismen der SchilddrüsenhormoneDuisburg Essen 2008
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Low FT3 levels are associated with acute decompensation and acute-on-chronic liver failure
International Liver Congress 2022 ; 22-26 June 2022, London, UK,In: Journal of Hepatology , Jg. 77 2022, Nr. Supplement 1: Abstracts of The International Liver CongressTM 2022, S. S341DOI (Open Access) -
MCT 8 and LAT 2 expression in differentially functioning benign and malignant thyroid tumors
57th Symposium of the German Society of Endocrinology (DGE), 19th–22th March, 2014, Dresden, Germany,In: Experimental and Clinical Endocrinology & Diabetes , Jg. 122 2014, Nr. 3, P082