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Fakultät Biologie, ZMB, Chemische Biologie
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Universitätsstr 2
45117 Essen
45117 Essen
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S03 S02 A55
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Professor/in, Chemische Biologie
Aktuelle Veranstaltungen
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SoSe 2025
- Praktikum zur Biochemie für Molekularbiologen
- Vorlesung Chemie für Lehramtsstudierende
- Mikro- und Zell- und chemische Biologie
- Praktikum Chemie für Lehramtsstudierende
- Biochemie für Molekularbiologen
- Molekularbiologie und Biochemie
- Bioorganik
- Mikro- und Zell- und chemische Biologie
- ZIA90221 Bioorganische Chemie
- Biochemie
- Klausur Einführung in die Biochemie ZJA40170
Vergangene Veranstaltungen (max. 10)
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WiSe 2024
- Einführung in die Medizinische Biologie
- Übung zur Biochemie
- Einführung in die Biochemie
- Modern Biomedicine/Beispiele biologischer Forschung (Teil 1)
- Molekulare Mikrobiologie und chemische Biologie (5.Sem. MedBio/Bio)
- Chemische Biologie für Molekularbiologen
- Allgemeine Methoden (Bachelor Bio)
- Nachrichtentechnik (alt: Signalübertragung und Modulation)
- Chemische Biologie
- Einführung in die Biochemie
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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An unusual glycerol-3-phosphate dehydrogenase in Sulfolobus acidocaldarius elucidates the diversity of glycerol metabolism across ArchaeaIn: Communications Biology , Jg. 8 2025, Nr. 1, 539DOI (Open Access)
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Bacterial pathogen deploys the iminosugar glycosyrin to manipulate plant glycobiologyIn: Science , Jg. 388 2025, Nr. 6744, S. 297 – 303
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Lack of AtMC1 catalytic activity triggers autoimmunity dependent on NLR stabilityIn: EMBO Reports 2025 , in pressDOI (Open Access)
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Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicityIn: Nature Communications , Jg. 16 2025, Nr. 1, 2110DOI (Open Access)
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Small Molecule-Induced Alterations of Protein Polyubiquitination Revealed by Mass-Spectrometric Ubiquitome AnalysisIn: Angewandte Chemie International Edition 2025 , in pressDOI (Open Access)
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Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitorsIn: Nature Communications , Jg. 16 2025, Nr. 1, 3208DOI (Open Access)
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The Actin‐Binding Prolyl‐Isomerase Par17 Sustains Its Substrate Selectivity by Interdomain AllosteryIn: Proteins: Structure, Function and Genetics 2025 , in pressDOI (Open Access)
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The CAPE1 peptide confers resistance against bacterial wilt in tomatoIn: Journal of Experimental Botany (JEB) 2025 , in pressDOI (Open Access)
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A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathwayIn: Nature Nanotechnology , Jg. 19 2024, Nr. 10, S. 1521 – 1531DOI (Open Access)
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Activity-based proteomics uncovers suppressed hydrolases and a neo-functionalised antibacterial enzyme at the plant–pathogen interfaceIn: New Phytologist , Jg. 241 2024, Nr. 1, S. 394 – 408DOI (Open Access)
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Bioengineering of syrbactin megasynthetases for immunoproteasome inhibitor productionIn: Chem , Jg. 10 2024, Nr. 10, S. 3212 – 3223DOI (Open Access)
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Characterization of 2-phenanthroate:CoA ligase from the sulfate-reducing, phenanthrene-degrading enrichment culture TRIPIn: Applied and Environmental Microbiology , Jg. 90 2024, Nr. 10, e0129624DOI (Open Access)
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Differences in the Synovial Fluid Proteome of Septic and Aseptic Implant FailureIn: Antibiotics , Jg. 13 2024, Nr. 4, 346DOI, Online Volltext (Open Access)
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Discovery of active mouse, plant and fungal cytochrome P450s in endogenous proteomes and upon expression in plantaIn: Scientific Reports , Jg. 14 2024, Nr. 1, 10091DOI (Open Access)
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Environmental activity-based protein profiling for function-driven enzyme discovery from natural communitiesIn: Environmental Microbiomes , Jg. 19 2024, Nr. 1, 36DOI, Online Volltext (Open Access)
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Extracellular plant subtilases dampen cold-shock peptide elicitor levelsIn: Nature Plants , Jg. 10 2024, Nr. 11, S. 1749 – 1760DOI (Open Access)
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Factors governing attachment of Rhizobium leguminosarum to legume roots at acid, neutral, and alkaline pHsIn: mSystems , Jg. 9 2024, Nr. 9, e0042224DOI (Open Access)
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Glutathione Transferase Photoaffinity Labeling Displays GST Induction by Safeners and Pathogen InfectionIn: Plant and Cell Physiology , Jg. 65 2024, Nr. 1, S. 128 – 141DOI (Open Access)
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High resolution analysis of proteolytic substrate processingIn: The Journal of Biological Chemistry (JBC) , Jg. 300 2024, Nr. 11, 107812DOI (Open Access)
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Induced degradation of SNAP-fusion proteinsIn: RSC Chemical Biology , Jg. 5 2024, Nr. 12, S. 1232 – 1247DOI (Open Access)
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Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptorIn: Current Biology , Jg. 34 2024, Nr. 11, S. 2279 – 2293.e6DOI (Open Access)
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Rational correction of pathogenic conformational defects in HTRA1In: Nature Communications , Jg. 15 2024, Nr. 1, 5944DOI (Open Access)
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Structure function analysis of ADP-dependent cyanobacterial phosphofructokinase reveals new phylogenetic grouping in the PFK-A familyIn: The Journal of Biological Chemistry (JBC) , Jg. 300 2024, Nr. 11, 107868DOI (Open Access)
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Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplastIn: Nature Communications , Jg. 15 2024, Nr. 1, 10431DOI (Open Access)
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The anti-tubercular callyaerins target the Mycobacterium tuberculosis-specific non-essential membrane protein Rv2113In: Cell Chemical Biology , Jg. 31 2024, Nr. 10, S. 1755 – 1771.e73DOI (Open Access)
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The proteome of Nicotiana benthamiana is shaped by extensive protein processingIn: New Phytologist , Jg. 243 2024, Nr. 3, S. 1034 – 1049DOI (Open Access)
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TopBP1 utilises a bipartite GINS binding mode to support genome replicationIn: Nature Communications , Jg. 15 2024, Nr. 1, 1797DOI, Online Volltext (Open Access)
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10q26 – The enigma in age-related macular degenerationIn: Progress in Retinal and Eye Research , Jg. 96 2023, 101154DOI (Open Access)
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Chemoproteomics Reveals the Pan-HER Kinase Inhibitor Neratinib To Target an Arabidopsis Epoxide Hydrolase Related to Phytohormone SignalingIn: ACS Chemical Biology , Jg. 18 2023, Nr. 5, S. 1076 – 1088
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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survivalIn: Cell , Jg. 186 2023, Nr. 10, S. 2176 – 2192.e22DOI (Open Access)
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Enhanced late blight resistance by engineering an EpiC2B-insensitive immune proteaseIn: Plant Biotechnology Journal , Jg. 22 2023, Nr. 2, S. 284 – 286DOI (Open Access)
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Facile Multicomponent Synthesis of Oxazolidinones from Primary Amines and Cesium (Hydrogen)CarbonateIn: European Journal of Organic Chemistry , Jg. 26 2023, Nr. 27, e202300135DOI (Open Access)
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IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilizationIn: Cell Chemical Biology , Jg. 30 2023, Nr. 6, S. 573 – 590.e6DOI (Open Access)
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The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPaseIn: Nature Communications , Jg. 14 2023, Nr. 1, 3258DOI, Online Volltext (Open Access)
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The root pathogen Aphanomyces euteiches secretes modular proteases in pea apoplast during host infectionIn: Frontiers in Plant Science (FPLS) , Jg. 14 2023, 1140101DOI (Open Access)
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Activity-Based Protein Profiling for the Identification of Novel Carbohydrate-Active Enzymes Involved in Xylan Degradation in the Hyperthermophilic Euryarchaeon Thermococcus sp. Strain 2319x1EIn: Frontiers in Microbiology , Jg. 12 2022, 734039DOI, Online Volltext (Open Access)
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BacPROTACs mediate targeted protein degradation in bacteriaIn: Cell , Jg. 185 2022, Nr. 13, S. 2338 – 2353.e18DOI (Open Access)
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Chemoproteomics‐Enabled Identification of 4‐Oxo‐β‐Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9In: Angewandte Chemie International Edition , Jg. 61 2022, Nr. 47, e202210498DOI (Open Access)
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Erratum: Author Correction: Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling (Communications biology (2022) 5 1 (1254))In: Communications Biology , Jg. 5 2022, Nr. 1, S. 1319DOI (Open Access)
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Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profilingIn: Communications Biology , Jg. 5 2022, Nr. 1, 1254DOI, Online Volltext (Open Access)
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Persister state-directed transitioning and vulnerability in melanoma
32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,In: Nature Communications , Jg. 13 2022, Nr. 1, S. 35 – 36DOI, Online Volltext (Open Access) -
Article leaf apoplast of field-grown potato analyzed by quantitative proteomics and activity-based protein profilingIn: International Journal of Molecular Sciences (IJMS) , Jg. 22 2021, Nr. 21, 12033DOI (Open Access)
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Correction to : Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteriaIn: Applied Microbiology and Biotechnology , Jg. 105 2021, Nr. 14-15, S. 6119 – 6119DOI (Open Access)
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Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasisIn: Cell Reports , Jg. 37 2021, Nr. 8, 110056DOI, Online Volltext (Open Access)
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Targeted substrate loop insertion by VCP/p97 during PP1 complex disassemblyIn: Nature Structural & Molecular Biology , Jg. 28 2021, Nr. 12, S. 964 – 971
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The chemical compound ‘Heatin’ stimulates hypocotyl elongation and interferes with the Arabidopsis NIT1-subfamily of nitrilasesIn: The Plant Journal , Jg. 106 2021, Nr. 6, S. 1523 – 1540DOI (Open Access)
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Accelerated trypsin autolysis by affinity polymer templatesIn: RSC Advances , Jg. 10 2020, Nr. 48, S. 28711 – 28719DOI (Open Access)
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Accelerated trypsin autolysis by affinity polymer templatesIn: RSC Advances , Jg. 10 2020, Nr. 48, S. 28711 – 28719DOI (Open Access)
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Activation by substoichiometric inhibitionIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Jg. 117 2020, Nr. 3, S. 1414 – 1418DOI (Open Access)
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Discovering the RNA-binding proteome of plant leaves with an improved RNA interactome capture methodIn: Biomolecules , Jg. 10 2020, Nr. 4, 661DOI (Open Access)
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From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins : the chemical biology of Ahp-cyclodepsipeptidesIn: Natural Product Reports , Jg. 37 2020, Nr. 2, S. 163 – 174
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Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteriaIn: Applied Microbiology and Biotechnology , Jg. 104 2020, Nr. 13, S. 5985 – 5998DOI (Open Access)
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Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain AdaptersIn: Journal of Molecular Biology (JMB) , Jg. 432 2020, Nr. 23, S. 6061 – 6074
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Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactionsIn: Nature Communications , Jg. 11 2020, Nr. 1, S. 3954DOI (Open Access)
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Targeting of parvulin interactors by diazirine mediated cross-linking discloses a cellular role of human Par14/17 in actin polymerizationIn: Biological Chemistry , Jg. 401 2020, Nr. 8, S. 955 – 968DOI (Open Access)
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Using proteomics for an insight into the performance of activated sludge in a lab-scale WWTPIn: International Biodeterioration & Biodegradation , Jg. 149 2020, S. 104934
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Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product FamilyIn: Chemistry - A European Journal , Jg. 26 2020, Nr. 39, S. 8524 – 8531DOI (Open Access)
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A homology-guided, genome-based proteome for improved proteomics in the alloploid Nicotiana benthamianaIn: BMC Genomics , Jg. 20 2019, Nr. 1, S. 722DOI (Open Access)
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Activity-based proteomics reveals nine target proteases for the recombinant protein-stabilizing inhibitor S/CYS8 in Nicotiana benthamianaIn: Plant Biotechnology Journal , Jg. 17 2019, Nr. 8, S. 1670 – 1678DOI (Open Access)
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Cathepsin L regulates metabolic networks controlling rapid cell growth and proliferationIn: Molecular and Cellular Proteomics (MCP) , Jg. 18 2019, Nr. 7, S. 1330 – 1344DOI (Open Access)
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Cathepsins Drive Anti-Inflammatory Activity by Regulating Autophagy and Mitochondrial Dynamics in Macrophage Foam CellsIn: Cellular Physiology and Biochemistry , Jg. 53 2019, Nr. 3, S. 550 – 572DOI (Open Access)
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Chemical Validation of DegS As a Target for the Development of Antibiotics with a Novel Mode of ActionIn: ChemMedChem , Jg. 14 2019, Nr. 11, S. 1074 – 1078
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Dynamic hydrolase labelling as a marker for seed quality in Arabidopsis seedsIn: Biochemical Journal , Jg. 476 2019, Nr. 5, S. 843 – 857DOI (Open Access)
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Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptidesIn: Science , Jg. 364 2019, Nr. 6436, eaav0748DOI (Open Access)
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Metabolic reconstruction of the genome of candidate Desulfatiglans TRIP_1 and identification of key candidate enzymes for anaerobic phenanthrene degradationIn: Environmental Microbiology , Jg. 21 2019, Nr. 4, S. 1267 – 1286DOI (Open Access)
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Plant chemical genetics reveals colistin sulphate as a SA and NPR1-independent PR1 inducer functioning via a p38-like kinase pathwayIn: Scientific Reports , Jg. 9 2019, Nr. 1, S. 11196DOI (Open Access)
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Proteases underground : Analysis of the maize root apoplast identifies organ specific papain-like cysteine protease activityIn: Frontiers in Plant Science (FPLS) , Jg. 10 2019DOI (Open Access)
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Triazine probes target ascorbate peroxidases in plantsIn: Plant Physiology , Jg. 180 2019, Nr. 4, S. 1848 – 1859DOI (Open Access)
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A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPasesIn: Angewandte Chemie International Edition , Jg. 57 2018, Nr. 6, S. 1576 – 1580
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An apoplastic peptide activates salicylic acid signalling in maizeIn: Nature Plants , Jg. 4 2018, Nr. 3, S. 172 – 180DOI (Open Access)
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Fermentative Spirochaetes mediate necromass recycling in anoxic hydrocarbon-contaminated habitatsIn: ISME Journal , Jg. 12 2018, Nr. 8, S. 2039 – 2050DOI (Open Access)
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HTRA1-Dependent Cell Cycle ProteomicsIn: Journal of Proteome Research , Jg. 17 2018, Nr. 8, S. 2679 – 2694
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Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent ProbesIn: ACS Chemical Biology , Jg. 13 2018, Nr. 5, S. 1307 – 1312
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Identification of the Natural Product RotihibinA as a TOR Kinase Signaling Inhibitor by Unbiased Transcriptional ProfilingIn: Chemistry - A European Journal , Jg. 24 2018, Nr. 48, S. 12500 – 12504
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Low Protease Content in Medicago truncatula Cell Cultures Facilitates Recombinant Protein ProductionIn: Biotechnology Journal , Jg. 13 2018, Nr. 7, 1800050
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Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular “Lysine Wrapping” of Oligoethylene Glycol (OEG) Moieties in ProteinsIn: Chemistry - A European Journal 2018DOI (Open Access)
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Multiplex Fluorescent, Activity-Based Protein Profiling Identifies Active α-Glycosidases and Other Hydrolases in PlantsIn: Plant Physiology , Jg. 177 2018, Nr. 1, S. 24 – 37DOI (Open Access)
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Protease Activities Triggered by Ralstonia solanacearum Infection in Susceptible and Tolerant Tomato LinesIn: Molecular and Cellular Proteomics (MCP) , Jg. 17 2018, Nr. 6, S. 1112 – 1125DOI (Open Access)
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The transcriptome, extracellular proteome and active secretome of agroinfiltrated Nicotiana benthamiana uncover a large, diverse protease repertoireIn: Plant Biotechnology Journal , Jg. 16 2018, Nr. 5, S. 1068 – 1084DOI (Open Access)
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Three unrelated protease inhibitors enhance accumulation of pharmaceutical recombinant proteins in Nicotiana benthamianaIn: Plant Biotechnology Journal , Jg. 16 2018, Nr. 10, S. 1797 – 1810DOI (Open Access)
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Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme FormationIn: Molecular Cell , Jg. 72 2018, Nr. 4, S. 766 – 777DOI (Open Access)
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Utilities for Mass Spectrometry Analysis of Proteins (UMSAP) : Fast post-processing of mass spectrometry dataIn: Rapid Communications in Mass Spectrometry , Jg. 32 2018, Nr. 19, S. 1659 – 1667
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Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic ArchaeaIn: Nature Communications , Jg. 8 2017, S. 15352DOI (Open Access)
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Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expressionIn: Antioxidants and Redox Signaling , Jg. 26 2017, Nr. 11, S. 563 – 582DOI (Open Access)
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Proteasome activity profiling uncovers alteration of catalytic β2 and β5 subunits of the stress-induced proteasome during salinity stress in tomato rootsIn: Frontiers in Plant Science (FPLS) , Jg. 8 2017, 107DOI (Open Access)
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Quantitative proteomics reveals ecophysiological effects of light and silver stress on the mixotrophic protist Poterioochromonas malhamensisIn: PLoS ONE , Jg. 12 2017, Nr. 1, S. e0168183DOI (Open Access)
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Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infectionsIn: The Plant Journal , Jg. 90 2017, Nr. 2, S. 418 – 430
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Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease InhibitorsIn: Angewandte Chemie International Edition , Jg. 56 2017, Nr. 29, Special Issue: 100th Anniversary of the Royal Australian Chemical Institute, S. 8555 – 8558
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The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian ClockIn: ACS Chemical Biology , Jg. 12 2017, Nr. 6, S. 1466 – 1471DOI (Open Access)
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A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosisIn: Chemical Science , Jg. 7 2016, S. 1322 – 1337DOI (Open Access)
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Capture of endogenously biotinylated proteins from Pseudomonas aeruginosa displays unexpected downregulation of LiuD upon iron nutritionIn: Bioorganic and Medicinal Chemistry , Jg. 24 2016, Nr. 15, S. 3330 – 3335
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VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break RepairIn: Molecular Cell , Jg. 64 2016, Nr. 1, S. 189 – 198DOI (Open Access)
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Chemical proteomics versus LeishmaniasisIn: Chemistry and Biology , Jg. 22 2015, Nr. 3, S. 309 – 310DOI (Open Access)
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Chemoproteomic Evaluation of the Polyacetylene Callyspongynic AcidIn: Chemistry - A European Journal , Jg. 21 2015, Nr. 30, S. 10721 – 10728DOI (Open Access)
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Determinants of amyloid fibril degradation by the PDZ protease HTRA1In: Nature Chemical Biology , Jg. 11 2015, Nr. 11, S. 862 – 869DOI (Open Access)
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Functional divergence of two secreted immune proteases of tomatoIn: Current Biology , Jg. 25 2015, Nr. 17, S. 2300 – 2306DOI (Open Access)
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Identification of human telomerase assembly inhibitors enabled by a novel method to produce hTERTIn: Nucleic Acids Research , Jg. 43 2015, Nr. 15 , art. no. e99DOI (Open Access)
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Subfamily-specific fluorescent probes for cysteine proteases display dynamic protease activities during seed germinationIn: Plant Physiology , Jg. 168 2015, Nr. 4, S. 1462 – 1475
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Synthesis of a hexahydropyrrolo indole (HPI) compound libraryIn: Bioorganic and Medicinal Chemistry , Jg. 23 2015, Nr. 11, S. 2636 – 2645
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A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thalianaIn: Nature Chemical Biology , Jg. 10 2014, Nr. 10, S. 830 – 836
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Building up a chemical proteomics network in Europe and beyondIn: ACS Chemical Biology , Jg. 9 2014, Nr. 8, S. 1647 – 1648
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Peptidyl succinimidyl peptides as taspase 1 inhibitorsIn: ChemBioChem , Jg. 15 2014, Nr. 15, S. 2233 – 2237
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Synthesis of the B-seco limonoid core scaffoldIn: Beilstein Journal of Organic Chemistry , Jg. 10 2014, S. 194 – 208DOI (Open Access)
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A substrate-inspired probe monitors translocation, activation, and subcellular targeting of bacterial type III effector protease AvrPphBIn: Chemistry and Biology , Jg. 20 2013, Nr. 2, S. 168 – 176
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Ahp cyclodepsipeptides: The impact of the ahp residue on the "Canonical Inhibition" of S1 serine proteasesIn: ChemBioChem , Jg. 14 2013, Nr. 11, S. 1301 – 1308
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Case studies of the synthesis of bioactive cyclodepsipeptide natural productsIn: Molecules: A Journal of Synthetic Chemistry and Natural Product Chemistry , Jg. 18 2013, Nr. 2, S. 1337 – 1367DOI (Open Access)
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Chemical proteomics with sulfonyl fluoride probes reveals selective labeling of functional tyrosines in glutathione transferasesIn: Chemistry and Biology , Jg. 20 2013, Nr. 4, S. 541 – 548DOI (Open Access)
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Diversity of allosteric regulation in proteasesIn: ACS Chemical Biology , Jg. 8 2013, Nr. 1, S. 19 – 26
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Profiling protein kinases and other ATP binding proteins in arabidopsis using acyl-ATP probesIn: Molecular and Cellular Proteomics (MCP) , Jg. 12 2013, Nr. 9, S. 2481 – 2496
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Pseudomonas syringae pv. syringae Uses Proteasome Inhibitor Syringolin A to Colonize from Wound Infection SitesIn: PLoS Pathogens , Jg. 9 2013, Nr. 3, S. e1003281DOI (Open Access)
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Streamlining chemical probe discovery : libraries of "fully functionalized" small molecules for phenotypic screeningIn: Angewandte Chemie International Edition , Jg. 52 2013, Nr. 5, S. 1368 – 1370
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A para-nitrophenol phosphonate probe labels distinct serine hydrolases of ArabidopsisIn: Bioorganic and Medicinal Chemistry , Jg. 20 2012, Nr. 2, S. 601 – 606
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Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cellsIn: Biochemistry , Jg. 51 2012, Nr. 34, S. 6880 – 6888
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Allosteric inhibition of Taspase1's pathobiological activity by enforced dimerization in vivoIn: The FASEB Journal , Jg. 26 2012, Nr. 8, S. 3421 – 3429
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Challenges in the syntheses of peptidic natural productsIn: Synthesis: Journal of Synthetic Organic Chemistry , Jg. 44 2012, Nr. 12, S. 1755 – 1777
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Chemical Biology Approaches Reveal Conserved Features of a C-Terminal Processing PDZ ProteaseIn: ChemBioChem , Jg. 13 2012, Nr. 3, S. 402 – 408
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Development of a Solid-Phase Approach to the Natural Product Class of Ahp-Containing CyclodepsipeptidesIn: European Journal of Organic Chemistry 2012, Nr. 8, S. 1616 – 1625
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Discovery of a potent and highly β1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketonesIn: Organic and Biomolecular Chemistry , Jg. 10 2012, Nr. 1, S. 181 – 194
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E. coli LoiP (YggG), a metalloprotease hydrolyzing Phe–Phe bondsIn: Molecular BioSystems , Jg. 8 2012, Nr. 6, S. 1775 – 1782
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Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregatesIn: The Journal of Biological Chemistry (JBC) , Jg. 287 2012, Nr. 25, S. 20931 – 20941
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Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenasesIn: Angewandte Chemie International Edition , Jg. 51 2012, Nr. 21, S. 5230 – 5233
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In Silico Identification of an Interferon InhibitorIn: ChemMedChem , Jg. 7 2012, Nr. 4, S. 555 – 557
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One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitorIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Jg. 109 2012, Nr. 45, S. 18367 – 18371
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Probes for activity-based profiling of plant proteasesIn: Physiologia Plantarum , Jg. 145 2012, Nr. 1, Special Issue: Plant Proteases, S. 18 – 27
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Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPPIn: Bioorganic and Medicinal Chemistry , Jg. 20 2012, Nr. 2, S. 597 – 600DOI (Open Access)
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Small-molecule stabilization of protein-protein interactions : An underestimated concept in drug discovery?In: Angewandte Chemie International Edition , Jg. 51 2012, Nr. 9, S. 2012 – 2018
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Sulfonyl Fluoride Analogues as Activity-Based Probes for Serine ProteasesIn: ChemBioChem , Jg. 13 2012, Nr. 16, S. 2327 – 2330
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The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipainsIn: Chemistry and Biology , Jg. 19 2012, Nr. 12, S. 1546 – 1555
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The impact of plant-pathogen studies on medicinal drug discoveryIn: Chemical Society Reviews , Jg. 41 2012, Nr. 8, S. 3168 – 3178
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Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesisIn: Organic Letters , Jg. 13 2011, Nr. 17, S. 4518 – 4521
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HTRA proteases : regulated proteolysis in protein quality controlIn: Nature Reviews Molecular Cell Biology , Jg. 12 2011, Nr. 3, S. 152 – 162
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Macrocyclic Proteasome InhibitorsIn: Current Medicinal Chemistry , Jg. 18 2011, Nr. 33, S. 5052 – 5060
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Mining the active proteome of Arabidopsis ThalianaIn: Frontiers in Plant Science (FPLS) , Jg. 2 2011, 89DOI (Open Access)
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Proteasome activity imaging and profiling characterizes bacterial effector Syringolin AIn: Plant Physiology , Jg. 155 2011, Nr. 1, S. 477 – 489DOI (Open Access)
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Protein quality control in the bacterial periplasmIn: Annual Review of Microbiology , Jg. 65 2011, S. 149 – 168
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Substrate induced remodeling of the active site regulates human HtrA1 activityIn: Nature Structural & Molecular Biology , Jg. 18 2011, S. 386 – 388
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Synthesis of the B-seco limonoid scaffoldIn: Chemical Communications: ChemComm , Jg. 47 2011, Nr. 23, S. 6545 – 6547
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The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins)In: Natural Product Reports , Jg. 28 2011, Nr. 11, S. 1854 – 1867
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The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity.In: Chemical Communications: ChemComm , Jg. 47 2011, Nr. 1, S. 385 – 387
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The yeast three-hybrid system as an experimental platform to identify proteins interacting with small signaling molecules in plant cells : Potential and limitationsIn: Frontiers in Plant Science (FPLS) , Jg. 2 2011, Nr. DEC, 101DOI (Open Access)
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A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-PyronesIn: Angewandte Chemie International Edition , Jg. 49 2010, Nr. 21, S. 3666 – 3670
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Activation Instead of Inhibition : Targeting Proenzymes for Small-Molecule InterventionIn: ChemBioChem , Jg. 11 2010, Nr. 5, S. 637 – 639
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Convergent synthesis and biological evaluation of syringolin a and derivatives as eukaryotic 20S proteasome inhibitorsIn: European Journal of Organic Chemistry 2010, Nr. 21, S. 3991 – 4003
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Conversion of a regulatory into a degradative proteaseIn: Journal of Molecular Biology (JMB) , Jg. 397 2010, Nr. 4, S. 957 – 966
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Determinants of structural and functional plasticity of a widely conserved protease chaperone complexIn: Nature Structural & Molecular Biology , Jg. 17 2010, Nr. 7, S. 837 – 843
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Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras SignalingIn: Molecular and Cellular Biology (MCB) , Jg. 30 2010, Nr. 19, S. 4698 – 4711
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LAP6/POLYKETIDE SYNTHASE A and LAP5/POLYKETIDE SYNTHASE B encode hydroxyalkyl α-pyrone synthases required for pollen development and sporopollenin biosynthesis in Arabidopsis thalianaIn: The Plant Cell , Jg. 22 2010, Nr. 12, S. 4045 – 4066DOI (Open Access)
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N-Acylation during glidobactin biosynthesis by the tridomain nonribosomal peptide synthetase module GlbFIn: Chemistry and Biology , Jg. 17 2010, Nr. 10, S. 1077 – 1083DOI (Open Access)
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Principles, implementation, and application of biology-oriented synthesis (BIOS).In: Biological Chemistry , Jg. 391 2010, Nr. 5, S. 491 – 497
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Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide AIn: Chemical Communications: ChemComm 2010, Nr. 46, S. 8857 – 8859
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Syrbactin class proteasome inhibitor-induced apoptosis and autophagy occurs in association with p53 accumulation and Akt/PKB activation in neuroblastomaIn: Biochemical Pharmacology , Jg. 80 2010, Nr. 2, S. 170 – 178
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The first small-molecule inhibitor of 14-3-3s : Modulating the master regulatorIn: ChemBioChem , Jg. 11 2010, Nr. 15, S. 2085 – 2087
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Biology-Oriented Combined Solid- and Solution-Phase Synthesis of a Macroline-Like Compound CollectionIn: Chemistry - A European Journal , Jg. 15 2009, Nr. 44, S. 11976 – 11984
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Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using ‘click chemistry’.In: The Plant Journal , Jg. 57 2009, Nr. 2, S. 373 – 385
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Peptidic small molecule activators of the stress sensor DegSIn: Molecular BioSystems , Jg. 5 2009, Nr. 9, S. 980 – 985
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Purification, crystallization and preliminary X-ray diffraction analysis of a plant subtilase.In: Acta crystallographica, Section F, Structural biology and crystallization communications online , Jg. 65 2009, Nr. 5, S. 522 – 525
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Selectivity profiling of DegP substrates and inhibitorsIn: Bioorganic and Medicinal Chemistry , Jg. 17 2009, Nr. 7, S. 2920 – 2924
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Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Jg. 106 2009, Nr. 40, S. 17223 – 17228
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Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coliIn: Research in Microbiology , Jg. 160 2009, Nr. 9, S. 660 – 666
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Synthetic and structural studies on Syringolin A and B reveal critical determinants for selectivity and potency of proteasome inhibitionIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Jg. 106 2009, Nr. 16, S. 6507 – 6512
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Syringolin A selectively labels the 20S proteasome in murine EL4 and wildtype and bortezomib adapted leukemic cell linesIn: ChemBioChem , Jg. 10 2009, Nr. 16, S. 2638 – 2643
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The ras pathway modulator melophlin a targets dynaminsIn: Angewandte Chemie International Edition , Jg. 48 2009, Nr. 39, S. 7240 – 7245
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Traceless solid phase synthesis of natural product inspired cis-1,2-dehydrodecalinsIn: Chemical Communications: ChemComm 2009, Nr. 20, S. 2923 – 2925
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γ-Pyrone natural products – a privileged compound class provided by nature.In: Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines , Jg. 17 2009, Nr. 6, S. 2304 – 2309
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A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanismIn: Nature , Jg. 452 2008, S. 755 – 758
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Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality controlIn: Angewandte Chemie International Edition , Jg. 47 2008, Nr. 7, S. 1332 – 1334
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Biology-inspired synthesis of compound librariesIn: Cellular and Molecular Life Sciences - CMLS , Jg. 65 2008, Nr. 7/8, S. 1186 – 1201
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Discovery of a New Class of Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B by Biology-Oriented SynthesisIn: Angewandte Chemie International Edition , Jg. 47 2008, Nr. 32, S. 5973 – 5977
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Identification and characterization of a novel proteasome inhibitor with apoptotic properties in neuroblastoma.In: Proceedings : annual meeting of the American Association for Cancer Research. , Jg. 49 2008, S. 773
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Identification of CNG trinucleotide repeat ligands with a FRET melting assayIn: ChemBioChem , Jg. 9 2008, Nr. 8, S. 1229 – 1234
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On the molecular mechanism of hormone action: Hunting the jasmonate target(s)In: Current topics in phytochemistry , Jg. 9 2008, S. 1 – 16
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β-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.In: Nature Chemical Biology , Jg. 4 2008, Nr. 9, S. 557 – 563
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Fluorescence-based melting assays for studying quadruplex ligandsIn: Methods: A Companion to Methods in Enzymology , Jg. 42 2007, Nr. 2, S. 183 – 195
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Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS).In: Chemistry: An Asian Journal , Jg. 2 2007, Nr. 9, S. 1109 – 1126
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Aminoglycoside-quinacridine conjugates : Towards recognition of the P6.1 element of Telomerase RNA.In: ChemBioChem , Jg. 7 2006, Nr. 2, S. 321 – 329
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Neomycin-capped aromatic platforms : Quadruplex DNA recognition and telomerase inhibitionIn: Organic and Biomolecular Chemistry , Jg. 4 2006, Nr. 6, S. 1049 – 1057
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TMC-95-Based Inhibitor Design Provides Evidence for the Catalytic Versatility of the ProteasomeIn: Chemistry and Biology , Jg. 13 2006, Nr. 6, S. 607 – 614
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Toward Semisynthetic Lipoproteins by Convergent Strategies Based on Click and Ligation ChemistryIn: ChemBioChem , Jg. 6 2005, Nr. 4, S. 625 – 628
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Binding mode of TMC-95A analogues to eukaryotic 20S proteasomeIn: ChemBioChem , Jg. 5 2004, Nr. 9, S. 1256 – 1266
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TMC-95A analogues with endocyclic biphenyl ether group as proteasome inhibitors.In: Chemistry & biodiversity : CB ; an official journal of the Center for the Study of Biological Complexity , Jg. 1 2004, Nr. 1, S. 161 – 173
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Synthesis of a TMC-95A ketomethylene analogue by cyclization via intramolecular Suzuki coupling.In: Organic Letters , Jg. 5 2003, Nr. 19, S. 3435 – 3437
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Navigation inside a protease: Substrate selection and product exit in the tricorn protease from Thermoplasma acidophilumIn: Journal of Molecular Biology (JMB) , Jg. 324 2002, Nr. 5, S. 1041 – 1050
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Structural plasticity and non-covalent substrate binding in the GroEL apical domain: A study using electrospray ionisation mass spectrometry and fluorescence binding studiesIn: The Journal of Biological Chemistry (JBC) , Jg. 277 2002, Nr. 36, S. 33115 – 33126
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Structure-based prediction of cyclization propensities of linear precursorsIn: International Journal of Peptide Research and Therapeutics , Jg. 9 2002, Nr. 2/3, S. 65 – 70
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Synthesis of TMC-95A analogues. Structure-based prediction of cyclization propensities of linear precursorsIn: Letters in Peptide Science , Jg. 9 2002, Nr. 2-3, S. 65 – 70
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The Core Structure of TMC-95A Is a Promising Lead for Reversible Proteasome InhibitionIn: Angewandte Chemie International Edition , Jg. 41 2002, Nr. 5, S. 780 – 783
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Editorial : When chemistry meets biology – Generating innovative concepts, methods and tools for scientific discovery in the plant sciencesIn: Frontiers in Plant Science (FPLS) , Jg. 7 2016, Nr. February, 76DOI (Open Access)
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Methods in Molecular Biology, Vol. 575: Chemogenomics: Methods and Applications Edited by Edgar Jacoby, Humana Press, Totowa 2009, VIII+315 pp., ISBN 978‐1‐60761‐273‐5In: ChemBioChem , Jg. 11 2010, Nr. 4, S. 582 – 583
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ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains2025DOI (Open Access)
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A non-autonomous protein quality control mechanism targeting tau aggregate propagation2024DOI (Open Access)
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Glycerol degradation in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius involves an unusual glycerol-3-phosphate dehydrogenase2024DOI (Open Access)
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Activity-based protein profiling with natural product-derived chemical probes in human cell lysatesIn: Activity-Based Proteomics: Methods and Protocols / Overkleeft, Herman S.; Florea, Bogdan I. (Hrsg.) 2017, S. 23 – 46
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The Identification of the Molecular Receptor of the Plant Hormone Abscisic AcidIn: Concepts and Case Studies in Chemical Biology / Waldmann, Herbert; Aerts, Hans; Janning, Petra (Hrsg.) 2014
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ProteolysisIn: Brenner's Encyclopedia of Genetics: Second Edition / Maloy, Stanley R.; Hughes, Kelly T. 2013, S. 501 – 503
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Small signaling molecules in the plant immune response : New tools for unraveling molecular mechanismsIn: Biology of plant-microbe interactions: Volume 7 / 14th International Congress on Molecular Plant-Microbe Interactions, Quebec, Canada, July 19-23, 2009 / Antoun, Hani; Avis, Tyler; Brisson, Louise; Prévost, Danielle; Trepanier, Martin (Hrsg.) 2010, S. 1 – 8
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G-quadruplex ligands as tools for elucidating c-MYC transcriptional regulationIn: Chemical Biology: learning through case studies / Waldmann, Herbert (Hrsg.) 2009, S. 247 – 259
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Targeted protein degradation in live cellsIn: Chemical Biology. Learning through Case Studies / Waldmann, Herbert (Hrsg.) 2009, S. 121 – 133
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Customized fused aromatics for structural recognition of nucleic acids.In: Chemistry of Nucleic acids components 2005, S. 245 – 249
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Inhibition of yeast 20S proteasome by biaryl- and biaryl ether cross-bridged tripeptide derivatives as TMC-95A analogsIn: Peptides Biology and Chemistry / Liu, Ke-Liang; Tam, James P. (Hrsg.) 2005
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Click and ligation chemistry for the synthesis of GPI-anchored membrane proteinsIn: Peptides 2004 : bridges between disciplines ; proceedings of the Third International and Twenty-Eighth European Peptide Symposium, September 5 - 10, 2004, Prague, Czech Republic / Flegel, Martin (Hrsg.) 2004, S. 595 – 596
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Structural determinants for 20S proteasome inhibition by TMC-95AIn: Peptides 2004 : bridges between disciplines ; proceedings of the Third International and Twenty-Eighth European Peptide Symposium, September 5 - 10, 2004, Prague, Czech Republic / Flegel, Martin (Hrsg.) 2004, S. 657 – 658
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Cyclic biphenyl ether tripeptides as proteasome inhibitorsIn: Peptide revolution: genomics, proteomics & therapeutics: 18th American Peptide Symposium, July 19 - 23, 2003, Boston, Massachusetts ; program and abstracts : (Biopolymers ; 71,3) / Chorev, Michael (Hrsg.) 2003, S. 348 – 349
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Entwicklung chemischer Sonden zur Proteasenforschung2009 (Max Planck Institute of Molecular Physiology: Forschungsbericht)