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Fakultät Biologie, ZMB, Chemische Biologie
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Universitätsstr 2
45117 Essen
45117 Essen
Raum
S03 S02 A55
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Funktionen
- Prodekan/in, Dekanat Fakultät Biologie
- Professor/in, Chemische Biologie
Aktuelle Veranstaltungen
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2020 WS
- Molekulare Mikrobiologie und chemische Biologie (5.Sem. MedBio/Bio)
- Praktikum molekulare Mikrobiologie und chemische Biologie (MedBio/Bio)
- Molekularbiologie und Biochemie
- Einführung in die Medizinische Biologie
- Allgemeine Methoden (Bachelor Bio)
- Übung zur Biochemie
- Chemische Biologie für Molekularbiologen
- Allgemeine Methoden Praktikum (Bachelor Bio); Priorität für G1/G2 oder G3/4 angeben!
- Einführung in die Biochemie
- ZJA40149 Chemische Biologie für Molekularbiologen
- Verbrennungsmotoren
- ZJA40170 Einführung in die Biochemie VO
Vergangene Veranstaltungen (max. 10)
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2020 SS
- Molekulare Mikro- und Zellbiologie
- Praktikum zur Biochemie für Molekularbiologen
- Mikro- und Zell- und chemische Biologie
- Vorlesung und Chemie-Praktikum für Lehramtsstudierende
- Bioorganik
- Molekularbiologie und Biochemie
- Biochemie für Molekularbiologen
- Chemie für Biologen
- Bioorganische Chemie
- Mathematik F
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Accelerated trypsin autolysis by affinity polymer templatesIn: RSC Advances Jg. 10 (2020) Nr. 48, S. 28711 - 28719
ISSN: 2046-2069Online Volltext: dx.doi.org/ (Open Access) -
Accelerated trypsin autolysis by affinity polymer templatesIn: RSC Advances Jg. 10 (2020) Nr. 48, S. 28711 - 28719
ISSN: 2046-2069Online Volltext: dx.doi.org/ (Open Access) -
Activation by substoichiometric inhibitionIn: Proceedings of the National Academy of Sciences of the United States of America Jg. 117 (2020) Nr. 3, S. 1414 - 1418
ISSN: 1091-6490; 0027-8424Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
Discovering the RNA-binding proteome of plant leaves with an improved RNA interactome capture methodIn: Biomolecules: open access journal Jg. 10 (2020) Nr. 4, S. 661
ISSN: 2218-273XOnline Volltext: dx.doi.org/ (Open Access) -
From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins : the chemical biology of Ahp-cyclodepsipeptidesIn: Natural Product Reports Jg. 37 (2020) Nr. 2, S. 163 - 174
ISSN: 0265-0568; 1460-4752Online Volltext: dx.doi.org/ -
Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteriaIn: Applied Microbiology and Biotechnology Jg. 104 (2020) S. 5985 - 5998
ISSN: 1432-0614; 0175-7598; 0171-1741; 0340-2118Online Volltext: dx.doi.org/ -
Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain AdaptersIn: Journal of Molecular Biology: JMB Jg. 432 (2020) Nr. 23, S. 6061 - 6074
ISSN: 1089-8638; 0022-2836Online Volltext: dx.doi.org/ -
Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactionsIn: Nature Communications Jg. 11 (2020) Nr. 1, S. 3954
ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access) -
Targeting of parvulin interactors by diazirine mediated cross-linking discloses a cellular role of human Par14/17 in actin polymerizationIn: Biological Chemistry Jg. 401 (2020) Nr. 8, S. 955 - 968
ISSN: 1437-4315; 1431-6730Online Volltext: dx.doi.org/ (Open Access) -
Using proteomics for an insight into the performance of activated sludge in a lab-scale WWTPIn: International Biodeterioration & Biodegradation Jg. 149 (2020) S. 104934
ISSN: 0964-8305Online Volltext: dx.doi.org/ -
Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product FamilyIn: Chemistry: A European Journal Jg. 26 (2020) Nr. 39, S. 8524 - 8531
ISSN: 1521-3765; 0947-6539Online Volltext: dx.doi.org/ (Open Access) -
A homology-guided, genome-based proteome for improved proteomics in the alloploid Nicotiana benthamianaIn: BMC Genomics Jg. 20 (2019) Nr. 1, S. 722
ISSN: 1471-2164Online Volltext: dx.doi.org/ (Open Access) -
Activity-based proteomics reveals nine target proteases for the recombinant protein-stabilizing inhibitor S/CYS8 in Nicotiana benthamianaIn: Plant Biotechnology Journal Jg. 17 (2019) Nr. 8, S. 1670 - 1678
ISSN: 1467-7652; 1467-7644Online Volltext: dx.doi.org/ (Open Access) -
Cathepsin L regulates metabolic networks controlling rapid cell growth and proliferationIn: Molecular and Cellular Proteomics Jg. 18 (2019) Nr. 7, S. 1330 - 1344
ISSN: 1535-9476; 1535-9484Online Volltext: dx.doi.org/ (Open Access) -
Cathepsins Drive Anti-Inflammatory Activity by Regulating Autophagy and Mitochondrial Dynamics in Macrophage Foam CellsIn: Cellular Physiology and Biochemistry Jg. 53 (2019) Nr. 3, S. 550 - 572
ISSN: 1015-8987; 1421-9778Online Volltext: dx.doi.org/ (Open Access) -
Chemical Validation of DegS As a Target for the Development of Antibiotics with a Novel Mode of ActionIn: ChemMedChem Jg. 14 (2019) Nr. 11, S. 1074 - 1078
ISSN: 1860-7187; 1860-7179Online Volltext: dx.doi.org/ -
Dynamic hydrolase labelling as a marker for seed quality in Arabidopsis seedsIn: The Biochemical Journal Jg. 476 (2019) Nr. 5, S. 843 - 857
ISSN: 1470-8728Online Volltext: dx.doi.org/ (Open Access) -
Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptidesIn: Science Jg. 364 (2019) Nr. 6436, S. eaav0748
ISSN: 1095-9203; 0036-8075Online Volltext: dx.doi.org/ -
Metabolic reconstruction of the genome of candidate Desulfatiglans TRIP_1 and identification of key candidate enzymes for anaerobic phenanthrene degradationIn: Environmental Microbiology Jg. 21 (2019) Nr. 4, S. 1267 - 1286
ISSN: 1462-2912; 1462-2920Online Volltext: dx.doi.org/ (Open Access) -
Plant chemical genetics reveals colistin sulphate as a SA and NPR1-independent PR1 inducer functioning via a p38-like kinase pathwayIn: Scientific Reports Jg. 9 (2019) Nr. 1, S. 11196
ISSN: 2045-2322Online Volltext: dx.doi.org/ (Open Access) -
Proteases underground : Analysis of the maize root apoplast identifies organ specific papain-like cysteine protease activityIn: Frontiers in Plant Science Jg. 10 (2019)
ISSN: 1664-462XOnline Volltext: dx.doi.org/ (Open Access) -
Triazine probes target ascorbate peroxidases in plantsIn: Plant Physiology Jg. 180 (2019) Nr. 4, S. 1848 - 1859
ISSN: 1532-2548; 0032-0889Online Volltext: dx.doi.org/ -
A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPasesIn: Angewandte Chemie International Edition Jg. 57 (2018) Nr. 6, S. 1576 - 1580
ISSN: 1521-3773; 1433-7851; 0570-0833Online Volltext: dx.doi.org/ -
An apoplastic peptide activates salicylic acid signalling in maizeIn: Nature Plants Jg. 4 (2018) Nr. 3, S. 172 - 180
ISSN: 2055-0278; 2055-026XOnline Volltext: dx.doi.org/ Online Volltext (Open Access) -
Fermentative Spirochaetes mediate necromass recycling in anoxic hydrocarbon-contaminated habitatsIn: ISME Journal Jg. 12 (2018) Nr. 8, S. 2039 - 2050
ISSN: 1751-7370; 1751-7362Online Volltext: dx.doi.org/ (Open Access) -
HTRA1-Dependent Cell Cycle ProteomicsIn: Journal of Proteome Research Jg. 17 (2018) Nr. 8, S. 2679 - 2694
ISSN: 1535-3893; 1535-3907Online Volltext: dx.doi.org/ -
Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent ProbesIn: ACS Chemical Biology Jg. 13 (2018) Nr. 5, S. 1307 - 1312
ISSN: 1554-8937; 1554-8929Online Volltext: dx.doi.org/ -
Identification of the Natural Product RotihibinA as a TOR Kinase Signaling Inhibitor by Unbiased Transcriptional ProfilingIn: Chemistry: A European Journal Jg. 24 (2018) Nr. 48, S. 12500 - 12504
ISSN: 0947-6539; 1521-3765Online Volltext: dx.doi.org/ -
Low Protease Content in Medicago truncatula Cell Cultures Facilitates Recombinant Protein ProductionIn: Biotechnology Journal Jg. 13 (2018) Nr. 7, S. 1800050
ISSN: 1860-6768Online Volltext: dx.doi.org/ -
Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular “Lysine Wrapping” of Oligoethylene Glycol (OEG) Moieties in ProteinsIn: Chemistry: A European Journal (2018)
ISSN: 0947-6539; 1521-3765Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
Multiplex Fluorescent, Activity-Based Protein Profiling Identifies Active α-Glycosidases and Other Hydrolases in PlantsIn: Plant Physiology Jg. 177 (2018) Nr. 1, S. 24 - 37
ISSN: 1532-2548; 0032-0889Online Volltext: dx.doi.org/ -
Protease Activities Triggered by Ralstonia solanacearum Infection in Susceptible and Tolerant Tomato LinesIn: Molecular and Cellular Proteomics Jg. 17 (2018) Nr. 6, S. 1112 - 1125
ISSN: 1535-9484; 1535-9476Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
The transcriptome, extracellular proteome and active secretome of agroinfiltrated Nicotiana benthamiana uncover a large, diverse protease repertoireIn: Plant Biotechnology Journal Jg. 16 (2018) Nr. 5, S. 1068 - 1084
ISSN: 1467-7652; 1467-7644Online Volltext: dx.doi.org/ (Open Access) -
Three unrelated protease inhibitors enhance accumulation of pharmaceutical recombinant proteins in Nicotiana benthamianaIn: Plant Biotechnology Journal Jg. 16 (2018) Nr. 10, S. 1797 - 1810
ISSN: 1467-7652; 1467-7644Online Volltext: dx.doi.org/ (Open Access) -
Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme FormationIn: Molecular Cell Jg. 72 (2018) Nr. 4, S. 766 - 777
ISSN: 1097-2765; 1097-4164Online Volltext: dx.doi.org/ (Open Access) -
Utilities for Mass Spectrometry Analysis of Proteins (UMSAP) : Fast post-processing of mass spectrometry dataIn: Rapid Communications in Mass Spectrometry Jg. 32 (2018) Nr. 19, S. 1659 - 1667
ISSN: 1097-0231; 0951-4198Online Volltext: dx.doi.org/ -
Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic ArchaeaIn: Nature Communications Jg. 8 (2017) S. 15352
ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access) -
Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expressionIn: Antioxidants and Redox Signaling Jg. 26 (2017) Nr. 11, S. 563 - 582
ISSN: 1523-0864; 1557-7716Online Volltext: dx.doi.org/ (Open Access) -
Proteasome activity profiling uncovers alteration of catalytic β2 and β5 subunits of the stress-induced proteasome during salinity stress in tomato rootsIn: Frontiers in Plant Science Jg. 8 (2017) S. 107
ISSN: 1664-462XOnline Volltext: dx.doi.org/ (Open Access) -
Quantitative proteomics reveals ecophysiological effects of light and silver stress on the mixotrophic protist Poterioochromonas malhamensisIn: PLoS ONE Jg. 12 (2017) Nr. 1, S. e0168183
ISSN: 1932-6203Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
Small Molecules from Deep within the GutIn: ChemBioChem Jg. 18 (2017) Nr. 11, S. 967 - 968
ISSN: 1439-4227; 1439-7633Online Volltext: dx.doi.org/ -
Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infectionsIn: The Plant Journal Jg. 90 (2017) Nr. 2, S. 418 - 430
ISSN: 1365-313X; 0960-7412Online Volltext: dx.doi.org/ -
Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease InhibitorsIn: Angewandte Chemie International Edition Jg. 56 (2017) Nr. 29, Special Issue: 100th Anniversary of the Royal Australian Chemical Institute, S. 8555 - 8558
ISSN: 1521-3773; 1433-7851Online Volltext: dx.doi.org/ -
The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian ClockIn: ACS Chemical Biology Jg. 12 (2017) Nr. 6, S. 1466 - 1471
ISSN: 1554-8937; 1554-8929Online Volltext: dx.doi.org/ (Open Access) -
Turning-ON ProteasomesIn: Cell Chemical Biology Jg. 24 (2017) Nr. 6, S. 653 - 655
ISSN: 2451-9456Online Volltext: dx.doi.org/ -
A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosisIn: Chemical Science Jg. 7 (2016) S. 1322 - 1337
ISSN: 2041-6539; 2041-6520Online Volltext: dx.doi.org/ (Open Access) -
Capture of endogenously biotinylated proteins from Pseudomonas aeruginosa displays unexpected downregulation of LiuD upon iron nutritionIn: Bioorganic and Medicinal Chemistry Jg. 24 (2016) Nr. 15, S. 3330 - 3335
ISSN: 1464-3391; 0968-0896Online Volltext: dx.doi.org/ -
VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break RepairIn: Molecular Cell Jg. 64 (2016) Nr. 1, S. 189 - 198
ISSN: 1097-4164; 1097-2765Online Volltext: dx.doi.org/ (Open Access) -
Chemical proteomics versus LeishmaniasisIn: Chemistry and Biology Jg. 22 (2015) Nr. 3, S. 309 - 310
ISSN: 1879-1301; 1074-5521Online Volltext: dx.doi.org/ (Open Access) -
Chemoproteomic Evaluation of the Polyacetylene Callyspongynic AcidIn: Chemistry: A European Journal Jg. 21 (2015) Nr. 30, S. 10721 - 10728
ISSN: 0947-6539; 1521-3765Online Volltext: dx.doi.org/ (Open Access) -
Determinants of amyloid fibril degradation by the PDZ protease HTRA1In: Nature Chemical Biology Jg. 11 (2015) Nr. 11, S. 862 - 869
ISSN: 1552-4450; 1552-4469Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
Functional divergence of two secreted immune proteases of tomatoIn: Current Biology Jg. 25 (2015) Nr. 17, S. 2300 - 2306
ISSN: 1879-0445; 0960-9822Online Volltext: dx.doi.org/ (Open Access) -
Identification of human telomerase assembly inhibitors enabled by a novel method to produce hTERTIn: Nucleic Acids Research Jg. 43 (2015) Nr. 15, art. no. e99
ISSN: 1362-4962; 0301-5610; 0305-1048Online Volltext: dx.doi.org/ (Open Access) -
Subfamily-specific fluorescent probes for cysteine proteases display dynamic protease activities during seed germinationIn: Plant Physiology Jg. 168 (2015) Nr. 4, S. 1462 - 1475
ISSN: 0032-0889Online Volltext: dx.doi.org/ -
Synthesis of a hexahydropyrrolo indole (HPI) compound libraryIn: Bioorganic and Medicinal Chemistry Jg. 23 (2015) Nr. 11, S. 2636 - 2645
ISSN: 1464-3391; 0968-0896Online Volltext: dx.doi.org/ -
A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thalianaIn: Nature Chemical Biology Jg. 10 (2014) Nr. 10, S. 830 - 836
ISSN: 1552-4469Online Volltext: dx.doi.org/ -
Building up a chemical proteomics network in Europe and beyondIn: ACS Chemical Biology Jg. 9 (2014) Nr. 8, S. 1647 - 1648
ISSN: 1554-8937; 1554-8929Online Volltext: dx.doi.org/ -
Peptidyl succinimidyl peptides as taspase 1 inhibitorsIn: ChemBioChem Jg. 15 (2014) Nr. 15, S. 2233 - 2237
ISSN: 1439-4227; 1439-7633Online Volltext: dx.doi.org/ -
Synthesis of the B-seco limonoid core scaffoldIn: Beilstein Journal of Organic Chemistry Jg. 10 (2014) S. 194 - 208
ISSN: 1860-5397; 2195-951XOnline Volltext: dx.doi.org/ (Open Access) -
A substrate-inspired probe monitors translocation, activation, and subcellular targeting of bacterial type III effector protease AvrPphBIn: Chemistry and Biology Jg. 20 (2013) Nr. 2, S. 168 - 176
ISSN: 1879-1301; 1074-5521Online Volltext: dx.doi.org/ -
Ahp cyclodepsipeptides: The impact of the ahp residue on the "Canonical Inhibition" of S1 serine proteasesIn: ChemBioChem Jg. 14 (2013) Nr. 11, S. 1301 - 1308
ISSN: 1439-4227; 1439-7633Online Volltext: dx.doi.org/ -
Case studies of the synthesis of bioactive cyclodepsipeptide natural productsIn: Molecules: A Journal of Synthetic Chemistry and Natural Product Chemistry Jg. 18 (2013) Nr. 2, S. 1337 - 1367
ISSN: 1420-3049Online Volltext: dx.doi.org/ (Open Access) -
Chemical proteomics with sulfonyl fluoride probes reveals selective labeling of functional tyrosines in glutathione transferasesIn: Chemistry and Biology Jg. 20 (2013) Nr. 4, S. 541 - 548
ISSN: 1879-1301; 1074-5521Online Volltext: dx.doi.org/ (Open Access) -
Diversity of allosteric regulation in proteasesIn: ACS Chemical Biology Jg. 8 (2013) Nr. 1, S. 19 - 26
ISSN: 1554-8937; 1554-8929Online Volltext: dx.doi.org/ -
Profiling protein kinases and other ATP binding proteins in arabidopsis using acyl-ATP probesIn: Molecular and Cellular Proteomics Jg. 12 (2013) Nr. 9, S. 2481 - 2496
ISSN: 1535-9476; 1535-9484Online Volltext: dx.doi.org/ -
Pseudomonas syringae pv. syringae Uses Proteasome Inhibitor Syringolin A to Colonize from Wound Infection SitesIn: PLoS Pathogens Jg. 9 (2013) Nr. 3, S. e1003281
ISSN: 1553-7374; 1553-7366Online Volltext: dx.doi.org/ (Open Access) -
Streamlining chemical probe discovery : libraries of "fully functionalized" small molecules for phenotypic screeningIn: Angewandte Chemie International Edition Jg. 52 (2013) Nr. 5, S. 1368 - 1370
ISSN: 1521-3773Online Volltext: dx.doi.org/ -
A para-nitrophenol phosphonate probe labels distinct serine hydrolases of ArabidopsisIn: Bioorganic and Medicinal Chemistry Jg. 20 (2012) Nr. 2, S. 601 - 606
ISSN: 1464-3391; 0968-0896Online Volltext: dx.doi.org/ -
Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cellsIn: Biochemistry Jg. 51 (2012) Nr. 34, S. 6880 - 6888
ISSN: 1520-4995; 0006-2960Online Volltext: dx.doi.org/ -
Allosteric inhibition of Taspase1's pathobiological activity by enforced dimerization in vivoIn: The FASEB Journal Jg. 26 (2012) Nr. 8, S. 3421 - 3429
ISSN: 0892-6638; 1530-6860Online Volltext: dx.doi.org/ -
Challenges in the syntheses of peptidic natural productsIn: Synthesis: Journal of Synthetic Organic Chemistry Jg. 44 (2012) Nr. 12, S. 1755 - 1777
ISSN: 0039-7881; 1437-210XOnline Volltext: dx.doi.org/ -
Chemical Biology Approaches Reveal Conserved Features of a C-Terminal Processing PDZ ProteaseIn: ChemBioChem Jg. 13 (2012) Nr. 3, S. 402 - 408
ISSN: 1439-4227; 1439-7633Online Volltext: dx.doi.org/ -
Development of a Solid-Phase Approach to the Natural Product Class of Ahp-Containing CyclodepsipeptidesIn: European Journal of Organic Chemistry (2012) Nr. 8, S. 1616 - 1625
ISSN: 1099-0690; 0075-4617; 0170-2041; 0365-5490; 0947-3440; 1434-193X; 1434-243XOnline Volltext: dx.doi.org/ -
Discovery of a potent and highly β1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketonesIn: Organic and Biomolecular Chemistry Jg. 10 (2012) Nr. 1, S. 181 - 194
ISSN: 1477-0539; 1477-0520Online Volltext: dx.doi.org/ -
E. coli LoiP (YggG), a metalloprotease hydrolyzing Phe–Phe bondsIn: Molecular BioSystems Jg. 8 (2012) Nr. 6, S. 1775 - 1782
ISSN: 1742-206XOnline Volltext: dx.doi.org/ Online Volltext -
Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregatesIn: Journal of Biological Chemistry Jg. 287 (2012) Nr. 25, S. 20931 - 20941
ISSN: 0021-9258; 1083-351XOnline Volltext: dx.doi.org/ -
Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenasesIn: Angewandte Chemie International Edition Jg. 51 (2012) Nr. 21, S. 5230 - 5233
ISSN: 1521-3773; 1433-7851Online Volltext: dx.doi.org/ -
In Silico Identification of an Interferon InhibitorIn: ChemMedChem Jg. 7 (2012) Nr. 4, S. 555 - 557
ISSN: 1860-7187; 1860-7179Online Volltext: dx.doi.org/ -
One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitorIn: Proceedings of the National Academy of Sciences of the United States of America Jg. 109 (2012) Nr. 45, S. 18367 - 18371
ISSN: 1091-6490; 0027-8424Online Volltext: dx.doi.org/ -
Probes for activity-based profiling of plant proteasesIn: Physiologia Plantarum Jg. 145 (2012) Nr. 1, Special Issue: Plant Proteases, S. 18 - 27
ISSN: 0031-9317; 1399-3054Online Volltext: dx.doi.org/ -
Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPPIn: Bioorganic and Medicinal Chemistry Jg. 20 (2012) Nr. 2, S. 597 - 600
ISSN: 1464-3391; 0968-0896Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
Small-molecule stabilization of protein-protein interactions : An underestimated concept in drug discovery?In: Angewandte Chemie International Edition Jg. 51 (2012) Nr. 9, S. 2012 - 2018
ISSN: 1521-3773; 1433-7851Online Volltext: dx.doi.org/ -
Sulfonyl Fluoride Analogues as Activity-Based Probes for Serine ProteasesIn: ChemBioChem Jg. 13 (2012) Nr. 16, S. 2327 - 2330
ISSN: 1439-4227; 1439-7633Online Volltext: dx.doi.org/ -
The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipainsIn: Chemistry and Biology Jg. 19 (2012) Nr. 12, S. 1546 - 1555
ISSN: 1074-5521Online Volltext: dx.doi.org/ -
The impact of plant-pathogen studies on medicinal drug discoveryIn: Chemical Society Reviews Jg. 41 (2012) Nr. 8, S. 3168 - 3178
ISSN: 1460-4744; 0306-0012Online Volltext: dx.doi.org/ -
Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesisIn: Organic Letters Jg. 13 (2011) Nr. 17, S. 4518 - 4521
ISSN: 1523-7052; 1523-7060Online Volltext: dx.doi.org/ -
HTRA proteases : regulated proteolysis in protein quality controlIn: Nature Reviews Molecular Cell Biology Jg. 12 (2011) Nr. 3, S. 152 - 162
ISSN: 1471-0072Online Volltext: dx.doi.org/ -
Macrocyclic Proteasome InhibitorsIn: Current Medicinal Chemistry Jg. 18 (2011) Nr. 33, S. 5052 - 5060
ISSN: 0929-8673; 1875-533XOnline Volltext: dx.doi.org/ -
Mining the active proteome of Arabidopsis ThalianaIn: Frontiers in Plant Science Jg. 2 (2011)
ISSN: 1664-462XOnline Volltext: dx.doi.org/ (Open Access) -
Proteasome activity imaging and profiling characterizes bacterial effector Syringolin AIn: Plant Physiology Jg. 155 (2011) Nr. 1, S. 477 - 489
ISSN: 0032-0889; 1532-2548Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
Protein quality control in the bacterial periplasmIn: Annual Review of Microbiology Jg. 65 (2011) S. 149 - 168
ISSN: 1545-3251; 0066-4227Online Volltext: dx.doi.org/ -
Substrate induced remodeling of the active site regulates human HtrA1 activityIn: Nature Structural & Molecular Biology Jg. 18 (2011) S. 386 - 388
ISSN: 1545-9993Online Volltext: dx.doi.org/ -
Synthesis of the B-seco limonoid scaffoldIn: Chemical Communications Jg. 47 (2011) Nr. 23, S. 6545 - 6547
ISSN: 1364-548X; 0009-241X; 0022-4936; 1359-7345Online Volltext: dx.doi.org/ -
The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins)In: Natural Product Reports Jg. 28 (2011) Nr. 11, S. 1854 - 1867
ISSN: 0265-0568; 1460-4752Online Volltext: dx.doi.org/ -
The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity.In: Chemical Communications Jg. 47 (2011) Nr. 1, S. 385 - 387
ISSN: 1364-548X; 0009-241X; 0022-4936; 1359-7345Online Volltext: dx.doi.org/ -
The yeast three-hybrid system as an experimental platform to identify proteins interacting with small signaling molecules in plant cells : Potential and limitationsIn: Frontiers in Plant Science Jg. 2 (2011) Nr. DEC, S. 101
ISSN: 1664-462XOnline Volltext: dx.doi.org/ (Open Access) -
A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-PyronesIn: Angewandte Chemie International Edition Jg. 49 (2010) Nr. 21, S. 3666 - 3670
ISSN: 0570-0833; 1433-7851Online Volltext: dx.doi.org/ -
Activation Instead of Inhibition : Targeting Proenzymes for Small-Molecule InterventionIn: ChemBioChem Jg. 11 (2010) Nr. 5, S. 637 - 639
ISSN: 1439-4227; 1439-7633Online Volltext: dx.doi.org/ Online Volltext -
Convergent synthesis and biological evaluation of syringolin a and derivatives as eukaryotic 20S proteasome inhibitorsIn: European Journal of Organic Chemistry (2010) Nr. 21, S. 3991 - 4003
ISSN: 1099-0690; 0075-4617; 0170-2041; 0365-5490; 0947-3440; 1434-193X; 1434-243XOnline Volltext: dx.doi.org/ -
Conversion of a regulatory into a degradative proteaseIn: Journal of Molecular Biology Jg. 397 (2010) Nr. 4, S. 957 - 966
ISSN: 0022-2836; 1089-8638Online Volltext: dx.doi.org/ -
Determinants of structural and functional plasticity of a widely conserved protease chaperone complexIn: Nature Structural & Molecular Biology Jg. 17 (2010) Nr. 7, S. 837 - 843
ISSN: 1545-9993; 1545-9985Online Volltext: dx.doi.org/ -
Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras SignalingIn: Molecular and Cellular Biology Jg. 30 (2010) Nr. 19, S. 4698 - 4711
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LAP6/POLYKETIDE SYNTHASE A and LAP5/POLYKETIDE SYNTHASE B encode hydroxyalkyl α-pyrone synthases required for pollen development and sporopollenin biosynthesis in Arabidopsis thalianaIn: The Plant Cell Jg. 22 (2010) Nr. 12, S. 4045 - 4066
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N-Acylation during glidobactin biosynthesis by the tridomain nonribosomal peptide synthetase module GlbFIn: Chemistry and Biology Jg. 17 (2010) Nr. 10, S. 1077 - 1083
ISSN: 1879-1301; 1074-5521Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
Principles, implementation, and application of biology-oriented synthesis (BIOS).In: Biological Chemistry Jg. 391 (2010) Nr. 5, S. 491 - 497
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Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A.In: Chemical Communications (2010) Nr. 46, S. 8857 - 8859
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Syrbactin class proteasome inhibitor-induced apoptosis and autophagy occurs in association with p53 accumulation and Akt/PKB activation in neuroblastomaIn: Biochemical Pharmacology Jg. 80 (2010) Nr. 2, S. 170 - 178
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The first small-molecule inhibitor of 14-3-3s : Modulating the master regulatorIn: ChemBioChem Jg. 11 (2010) Nr. 15, S. 2085 - 2087
ISSN: 1439-4227; 1439-7633Online Volltext: dx.doi.org/ -
Biology-Oriented Combined Solid- and Solution-Phase Synthesis of a Macroline-Like Compound CollectionIn: Chemistry: A European Journal Jg. 15 (2009) Nr. 44, S. 11976 - 11984
ISSN: 0947-6539; 1521-3765Online Volltext: dx.doi.org/ -
Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using ‘click chemistry’.In: The Plant Journal Jg. 57 (2009) Nr. 2, S. 373 - 385
ISSN: 1365-313X -
Peptidic small molecule activators of the stress sensor DegSIn: Molecular BioSystems Jg. 5 (2009) Nr. 9, S. 980 - 985
ISSN: 1742-206XOnline Volltext: dx.doi.org/ -
Purification, crystallization and preliminary X-ray diffraction analysis of a plant subtilase.In: Acta crystallographica, Section F, Structural biology and crystallization communications online Jg. 65 (2009) Nr. 5, S. 522 - 525
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Selectivity profiling of DegP substrates and inhibitorsIn: Bioorganic and Medicinal Chemistry Jg. 17 (2009) Nr. 7, S. 2920 - 2924
ISSN: 0968-0896; 1464-3391Online Volltext: dx.doi.org/ -
Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3In: Proceedings of the National Academy of Sciences of the United States of America Jg. 106 (2009) Nr. 40, S. 17223 - 17228
ISSN: 1091-6490; 0027-8424Online Volltext: dx.doi.org/ -
Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coliIn: Research in Microbiology Jg. 160 (2009) Nr. 9, S. 660 - 666
ISSN: 0923-2508; 1769-7123Online Volltext: dx.doi.org/ -
Synthetic and structural studies on Syringolin A and B reveal critical determinants for selectivity and potency of proteasome inhibitionIn: Proceedings of the National Academy of Sciences of the United States of America Jg. 106 (2009) Nr. 16, S. 6507 - 6512
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Syringolin A selectively labels the 20S proteasome in murine EL4 and wildtype and bortezomib adapted leukemic cell linesIn: ChemBioChem Jg. 10 (2009) Nr. 16, S. 2638 - 2643
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The Ras pathway modulator Melophlin A targets dynaminsIn: Angewandte Chemie Jg. 121 (2009) Nr. 39, S. 7376 - 7381
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Traceless solid phase synthesis of natural product inspired cis-1,2-dehydrodecalinsIn: Chemical Communications (2009) Nr. 20, S. 2923 - 2925
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γ-Pyrone natural products – a privileged compound class provided by nature.In: Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines Jg. 17 (2009) Nr. 6, S. 2304 - 2309
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A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanismIn: Nature Jg. 452 (2008) S. 755 - 758
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Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality controlIn: Angewandte Chemie International Edition Jg. 47 (2008) Nr. 7, S. 1332 - 1334
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Allosteric regulation of proteasesIn: ChemBioChem Jg. 9 (2008) Nr. 18, S. 2920 - 2928
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Biology-inspired synthesis of compound librariesIn: Cellular and Molecular Life Sciences - CMLS Jg. 65 (2008) Nr. 7/8, S. 1186 - 1201
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Discovery of a New Class of Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B by Biology-Oriented SynthesisIn: Angewandte Chemie - International Edition Jg. 47 (2008) Nr. 32, S. 5973 - 5977
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Identification and characterization of a novel proteasome inhibitor with apoptotic properties in neuroblastoma.In: Proceedings : annual meeting of the American Association for Cancer Research. Jg. 49 (2008) S. 773
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Identification of CNG trinucleotide repeat ligands with a FRET melting assayIn: ChemBioChem Jg. 9 (2008) Nr. 8, S. 1229 - 1234
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On the molecular mechanism of hormone action: Hunting the jasmonate target(s)In: Current topics in phytochemistry Jg. 9 (2008) S. 1 - 16
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β-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.In: Nature chemical biology Jg. 4 (2008) Nr. 9, S. 557 - 563
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Fluorescence-based melting assays for studying quadruplex ligandsIn: Methods: A Companion to Methods in Enzymology Jg. 42 (2007) Nr. 2, S. 183 - 195
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Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS).In: Chemistry - An Asian Journal Jg. 2 (2007) Nr. 9, S. 1109 - 1126
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Aminoglycoside-quinacridine conjugates : Towards recognition of the P6.1 element of Telomerase RNA.In: ChemBioChem Jg. 7 (2006) Nr. 2, S. 321 - 329
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Neomycin-capped aromatic platforms : Quadruplex DNA recognition and telomerase inhibitionIn: Organic and Biomolecular Chemistry Jg. 4 (2006) Nr. 6, S. 1049 - 1057
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TMC-95-Based Inhibitor Design Provides Evidence for the Catalytic Versatility of the ProteasomeIn: Chemistry and Biology Jg. 13 (2006) Nr. 6, S. 607 - 614
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Toward Semisynthetic Lipoproteins by Convergent Strategies Based on Click and Ligation ChemistryIn: ChemBioChem Jg. 6 (2005) Nr. 4, S. 625 - 628
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Binding mode of TMC-95A analogues to eukaryotic 20S proteasomeIn: ChemBioChem Jg. 5 (2004) Nr. 9, S. 1256 - 1266
ISSN: 1439-4227; 1439-7633Online Volltext: dx.doi.org/ -
TMC-95A analogues with endocyclic biphenyl ether group as proteasome inhibitors.In: Chemistry & biodiversity : CB ; an official journal of the Center for the Study of Biological Complexity Jg. 1 (2004) Nr. 1, S. 161 - 173
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Synthesis of a TMC-95A ketomethylene analogue by cyclization via intramolecular Suzuki coupling.In: Organic Letters Jg. 5 (2003) Nr. 19, S. 3435 - 3437
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Navigation inside a protease: Substrate selection and product exit in the tricorn protease from Thermoplasma acidophilumIn: Journal of Molecular Biology Jg. 324 (2002) Nr. 5, S. 1041 - 1050
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Structural plasticity and non-covalent substrate binding in the GroEL apical domain: A study using electrospray ionisation mass spectrometry and fluorescence binding studiesIn: Journal of Biological Chemistry Jg. 277 (2002) Nr. 36, S. 33115 - 33126
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Structure-based prediction of cyclization propensities of linear precursorsIn: International Journal of Peptide Research and Therapeutics Jg. 9 (2002) Nr. 2/3, S. 65 - 70
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Synthesis of TMC-95A analogues. Structure-based prediction of cyclization propensities of linear precursorsIn: Letters in Peptide Science Jg. 9 (2002) Nr. 2-3, S. 65 - 70
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The Core Structure of TMC-95A Is a Promising Lead for Reversible Proteasome InhibitionIn: Angewandte Chemie - International Edition Jg. 41 (2002) Nr. 5, S. 780 - 783
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Editorial : When chemistry meets biology – Generating innovative concepts, methods and tools for scientific discovery in the plant sciencesIn: Frontiers in Plant Science Jg. 7 (2016) Nr. February, S. 76
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Methods in Molecular Biology, Vol. 575: Chemogenomics: Methods and Applications Edited by Edgar Jacoby, Humana Press, Totowa 2009, VIII+315 pp., ISBN 978‐1‐60761‐273‐5In: ChemBioChem Jg. 11 (2010) Nr. 4, S. 582 - 583
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Activity-based protein profiling with natural product-derived chemical probes in human cell lysatesIn: Activity-Based Proteomics: Methods and Protocols / Overkleeft, Herman S.; Florea, Bogdan I. (Hrsg.) 2017, S. 23 - 46
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The Identification of the Molecular Receptor of the Plant Hormone Abscisic AcidIn: Concepts and Case Studies in Chemical Biology / Waldmann, Herbert; Aerts, Hans; Janning, Petra (Hrsg.) 2014
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ProteolysisIn: Brenner's Encyclopedia of Genetics: Second Edition / Maloy, Stanley R.; Hughes, Kelly T. 2013, S. 501 - 503
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Small signaling molecules in the plant immune response : New tools for unraveling molecular mechanismsIn: Biology of plant-microbe interactions: Volume 7 / 14th International Congress on Molecular Plant-Microbe Interactions, Quebec, Canada, July 19-23, 2009 / Antoun, Hani; Avis, Tyler; Brisson, Louise; Prévost, Danielle; Trepanier, Martin (Hrsg.) 2010, S. 1 - 8
ISBN: 978-0-9654625-6-3 -
G-quadruplex ligands as tools for elucidating c-MYC transcriptional regulationIn: Chemical Biology: learning through case studies / Waldmann, Herbert (Hrsg.) 2009, S. 247 - 259
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Targeted protein degradation in live cellsIn: Chemical Biology. Learning through Case Studies / Waldmann, Herbert (Hrsg.) 2009, S. 121 - 133
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Customized fused aromatics for structural recognition of nucleic acids.In: Chemistry of Nucleic acids components 2005, S. 245 - 249
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Inhibition of yeast 20S proteasome by biaryl- and biaryl ether cross-bridged tripeptide derivatives as TMC-95A analogsIn: Peptides Biology and Chemistry / Liu, Ke-Liang; Tam, James P. (Hrsg.) 2005
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Click and ligation chemistry for the synthesis of GPI-anchored membrane proteinsIn: Peptides 2004 : bridges between disciplines ; proceedings of the Third International and Twenty-Eighth European Peptide Symposium, September 5 - 10, 2004, Prague, Czech Republic / Flegel, Martin (Hrsg.) 2004, S. 595 - 596
ISBN: 965-908-330-0 -
Structural determinants for 20S proteasome inhibition by TMC-95AIn: Peptides 2004 : bridges between disciplines ; proceedings of the Third International and Twenty-Eighth European Peptide Symposium, September 5 - 10, 2004, Prague, Czech Republic / Flegel, Martin (Hrsg.) 2004, S. 657 - 658
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Cyclic biphenyl ether tripeptides as proteasome inhibitorsIn: Peptide revolution: genomics, proteomics & therapeutics: 18th American Peptide Symposium, July 19 - 23, 2003, Boston, Massachusetts ; program and abstracts : (Biopolymers ; 71,3) / Chorev, Michael (Hrsg.) 2003, S. 348 - 349
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The Janus-faced role of KDM5B heterogeneity in melanoma : Differentiation as a situational driver of both growth arrest and drug-resistance(2020) 50 Seiten
Online Volltext: dx.doi.org/ (Open Access) -
Entwicklung chemischer Sonden zur Proteasenforschung(2009)
(Max Planck Institute of Molecular Physiology: Forschungsbericht)