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2024 WS
- Anatomie 1: Praktikum der Mikroskopischen Anatomie für Medizintechniker
- Anatomie 1: Vorlesung Propädeutik (Bewegungsapparat und Muskelmechanik) für Medizintechniker
- Anatomie 1: Begleitvorlesung zum Praktikum der Mikroskopischen Anatomie für Medizintechniker
- Reproduktionsbiologisches Seminar
- Anleitung zum wissenschaftlichen Arbeiten
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2024 SS
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2023 WS
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Host-derived CEACAM-laden vesicles engage enterotoxigenic Escherichia coli for elimination and toxin neutralizationIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 121 (2024) Nr. 38, e2410679121Online Volltext: dx.doi.org/ (Open Access)
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Insights into circulating CEACAM1 in insulin clearance and disease progression : Evidence from the Portuguese PREVADIAB2 studyIn: European Journal of Clinical Investigation Jg. 54 (2024) Nr. S2, Special Issue: CEACAM in Health and Disease, e14344Online Volltext: dx.doi.org/ (Open Access)
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Author Correction: Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesisIn: Nature Communications Jg. 14 (2023) Nr. 1, S. 2675Online Volltext: dx.doi.org/ (Open Access)
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Correction to: Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cellsIn: Cancer Gene Therapy Jg. 30 (2023) Nr. 6, 926Online Volltext: dx.doi.org/
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Forskolin versus cAMP-Induced Decidualization and Survival of Endometrial Stromal Cells of Endometriosis PatientsIn: Reproductive sciences Jg. 30 (2023) Nr. 9, S. 2680 - 2691Online Volltext: dx.doi.org/
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Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesisIn: Nature Communications Jg. 14 (2023) Nr. 1, 2275Online Volltext: dx.doi.org/ (Open Access)
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Loss of CEACAM1 in endothelial cells causes hepatic fibrosisIn: Metabolism Jg. 144 (2023) 155562Online Volltext: dx.doi.org/ (Open Access)
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Proof of Principle of Combining Fluorescence-Guided Surgery with Photoimmunotherapy to Improve the Outcome of Pancreatic Cancer Therapy in an Orthotopic Mouse ModelIn: Annals of Surgical Oncology Jg. 30 (2023) Nr. 1, S. 618 - 625Online Volltext: dx.doi.org/ (Open Access)
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Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cellsIn: Cancer Gene Therapy Jg. 29 (2022) Nr. 11, S. 1676 - 1685Online Volltext: dx.doi.org/
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Antibody ligation of CEACAM1, CEACAM3, and CEACAM6, differentially enhance the cytokine release of human neutrophils in responses to Candida albicansIn: Cellular Immunology Jg. 371 (2022) 104459Online Volltext: dx.doi.org/ (Open Access)
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CatSper and its CaM-like Ca²⁺ sensor EFCAB9 are necessary for the path chirality of spermIn: The FASEB Journal Jg. 36 (2022) Nr. 5, e22288Online Volltext: dx.doi.org/ (Open Access)
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MXene-Assisted Ablation of Cells with a Pulsed Near-Infrared LaserIn: ACS Applied Materials & Interfaces Jg. 14 (2022) Nr. 25, S. 28683 - 28696Online Volltext: dx.doi.org/
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A Novel Color-Coded Liver Metastasis Mouse Model to Distinguish Tumor and Adjacent Liver SegmentIn: Journal of Surgical Research Jg. 264 (2021) S. 327 - 333Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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A patient-derived orthotopic xenograft model of gastroesophageal-junction adenocarcinoma translated to the clinic by tumor-targeting fluorescent antibodies to carcinoembryonic-antigen-related cell-adhesion moleculesIn: In Vivo Jg. 35 (2021) Nr. 4, S. 1959 - 1963Online Volltext: dx.doi.org/ (Open Access)
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Bacterial protein domains with a novel Ig-like fold target human CEACAM receptorsIn: The EMBO Journal Jg. 40 (2021) Nr. 7, S. e106103Online Volltext: dx.doi.org/ (Open Access)
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Engagement of CEACAM1 by helicobacter pylori HopQ is important for the activation of non-canonical NF-κB in gastric epithelial cellsIn: Microorganisms Jg. 9 (2021) Nr. 8, 1748Online Volltext: dx.doi.org/ (Open Access)
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Evaluation of carcinoembryonic antigen-related cell adhesion molecule 1 blood serum levels in women at high risk for preeclampsiaIn: American Journal of Reproductive Immunology Jg. 85 (2021) Nr. 5, e13375Online Volltext: dx.doi.org/
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Fusobacterium nucleatum CbpF Mediates Inhibition of T Cell Function Through CEACAM1 ActivationIn: Frontiers in Cellular and Infection Microbiology Jg. 11 (2021) 692544Online Volltext: dx.doi.org/ (Open Access)
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Acinetobacter baumannii targets human carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) for invasion of pneumocytesIn: mSystems Jg. 5 (2020) Nr. 6, e00604-20Online Volltext: dx.doi.org/ (Open Access)
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Anti-carcinoembryonic antigen-related cell adhesion molecule antibody for fluorescence visualization of primary colon cancer and metastases in patient-derived orthotopic xenograft mouse modelsIn: OncoTarget Jg. 11 (2020) Nr. 4, S. 429 - 439Online Volltext: dx.doi.org/ (Open Access)
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CEACAM1 regulates CD8⁺ T cell immunity and protects from severe pathology during Citrobacter rodentium induced colitisIn: Gut Microbes Jg. 11 (2020) Nr. 6, S. 1790 - 1805Online Volltext: dx.doi.org/ (Open Access)
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CEACAMs serve as toxin-stimulated receptors for enterotoxigenic Escherichia coliIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 117 (2020) Nr. 46, S. 29055 - 29062Online Volltext: dx.doi.org/ (Open Access)
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Cysteine residues in Helicobacter pylori Adhesin HopQ are required for CEACAM–HopQ interaction and subsequent CagA translocationIn: Microorganisms Jg. 8 (2020) Nr. 4, 465Online Volltext: dx.doi.org/ (Open Access)
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Fluorophore-conjugated Helicobacter pylori recombinant membrane protein (HopQ) labels primary colon cancer and metastases in orthotopic mouse models by binding CEA-related cell adhesion moleculesIn: Translational Oncology Jg. 13 (2020) Nr. 12, S. 100857Online Volltext: dx.doi.org/ (Open Access)
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Type IV secretion of Helicobacter pylori CagA into oral epithelial cells is prevented by the absence of CEACAM receptor expressionIn: Gut Pathogens Jg. 12 (2020) Nr. 1, S. 25Online Volltext: dx.doi.org/ (Open Access)
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Expression of CEACAM1 or CEACAM5 in AZ-521 cells restores the type IV secretion deficiency for translocation of CagA by Helicobacter pyloriIn: Cellular Microbiology Jg. 21 (2019) Nr. 1, S. e12965Online Volltext: dx.doi.org/ (Open Access)
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Extracellular chromatin triggers release of soluble CEACAM8 upon activation of neutrophilsIn: Frontiers in Immunology Jg. 10 (2019) S. 1346Online Volltext: dx.doi.org/ (Open Access)
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Fusobacterium nucleatum supresses anti-tumor immunity by activating CEACAM1In: OncoImmunology Jg. 8 (2019) Nr. 6, e1581531Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Fusobacterium spp. target human CEACAM1 via the trimeric autotransporter adhesin CbpFIn: Journal of Oral Microbiology Jg. 11 (2019) Nr. 1, S. 1565043Online Volltext: dx.doi.org/ (Open Access)
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Size Matters: The Functional Role of the CEACAM1 Isoform Signature and Its Impact for NK Cell-Mediated Killing in MelanomaIn: Cancers Jg. 11 (2019) Nr. 3, S. 356Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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The Helicobacter pylori HopQ outermembrane protein inhibits immune cell activitiesIn: OncoImmunology Jg. 8 (2019) Nr. 4, e1553487Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Unaltered Fungal Burden and Lethality in Human CEACAM1-Transgenic Mice During Candida albicans Dissemination and Systemic InfectionIn: Frontiers in Microbiology Jg. 10 (2019) S. 2703Online Volltext: dx.doi.org/ (Open Access)
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CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infectionIn: Nature Communications Jg. 9 (2018) 2561Online Volltext: dx.doi.org/ (Open Access)
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Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in miceIn: Hepatology Jg. 68 (2018) Nr. 1, S. 200 - 214Online Volltext: dx.doi.org/
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Gene Therapy for Modulation of T-Cell-Mediated Immune Response Provoked by Corneal TransplantationIn: Human Gene Therapy Jg. 29 (2018) Nr. 4, S. 467 - 479Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMsIn: The EMBO Journal Jg. 37 (2018) Nr. 13,Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scalesIn: Journal of Extracellular Vesicles (JEV) Jg. 7 (2018) Nr. 1, S. 1528109Online Volltext: dx.doi.org/ (Open Access)
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The deregulation of miR-17/CCND1 axis during neuroendocrine transdifferentiation of LNCaP prostate cancer cellsIn: PLoS ONE Jg. 13 (2018) Nr. 7, e0200472Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Binding of Candida albicans to Human CEACAM1 and CEACAM6 Modulates the Inflammatory Response of Intestinal Epithelial CellsIn: mBio Jg. 8 (2017) Nr. 2, S. e02142 - 16Online Volltext: dx.doi.org/ (Open Access)
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Effects of the Mammalian Target of Rapamycin Inhibitor Everolimus on Hepatitis C Virus Replication In Vitro and In VivoIn: Transplantation Proceedings Jg. 49 (2017) Nr. 8, S. 1947 - 1955Online Volltext: dx.doi.org/
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Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMsIn: Nature Microbiology Jg. 2 (2017) 16189Online Volltext: dx.doi.org/ (Open Access)
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Poly (glycerol sebacate)-poly (ε-caprolactone) blend nanofibrous scaffold as intrinsic bio- and immunocompatible system for corneal repairIn: Acta Biomaterialia Jg. 50 (2017) S. 370 - 380Online Volltext: dx.doi.org/
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Soluble CEACAM1 and CEACAM6 are differently expressed in blood serum of pregnant women during normal pregnancyIn: American Journal of Reproductive Immunology Jg. 78 (2017) Nr. 4, S. e12700Online Volltext: dx.doi.org/
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Björn J. Öbrink : (1943-2015)In: Experimental Cell Research Jg. 341 (2016) Nr. 1, S. 75 - 76Online Volltext: dx.doi.org/
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Efficient and safe gene delivery to human corneal endothelium using magnetic nanoparticlesIn: Nanomedicine Jg. 11 (2016) Nr. 14, S. 1787 - 1800Online Volltext: dx.doi.org/
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Moraxella catarrhalis induces CEACAM3-Syk-CARD9-dependent activation of human granulocytesIn: Cellular Microbiology Jg. 18 (2016) Nr. 11, S. 1570 - 1582Online Volltext: dx.doi.org/ (Open Access)
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Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodiesIn: mAbs Jg. 8 (2016) Nr. 3, S. 491 - 500Online Volltext: dx.doi.org/ (Open Access)
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CEACAM1 induces B-cell survival and is essential for protective antiviral antibody productionIn: Nature Communications Jg. 6 (2015) 6217Online Volltext: dx.doi.org/ (Open Access)
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CEACAM1-3S drives melanoma cells into NK cell-mediated cytolysis and enhances patient survivalIn: Cancer Research Jg. 75 (2015) Nr. 9, S. 1897 - 1907Online Volltext: dx.doi.org/ (Open Access)
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CEACAM1-4L promotes anchorage-independent growth in melanomaIn: Frontiers in Oncology Jg. 5 (2015) 234Online Volltext: dx.doi.org/ (Open Access)
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EPHB4 tyrosine-kinase receptor expression and biological significance in soft tissue sarcomaIn: International Journal of Cancer Jg. 136 (2015) Nr. 8, S. 1781 - 1791Online Volltext: dx.doi.org/ (Open Access)
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Functional capacities of human igm memory b cells in early inflammatory responses and secondary germinal center reactionsIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 112 (2015) Nr. 6, S. E546 - E555Online Volltext: dx.doi.org/ (Open Access)
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MITF is a critical regulator of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in malignant melanomaIn: Pigment Cell and Melanoma Research Jg. 28 (2015) Nr. 6, S. 736 - 740Online Volltext: dx.doi.org/
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Moraxella catarrhalis induces an immune response in the murine lung that is independent of human CEACAM5 expression and long-term smoke exposureIn: American Journal of Physiology: Lung Cellular and Molecular Physiology Jg. 309 (2015) Nr. 3, S. L250 - L261Online Volltext: dx.doi.org/ (Open Access)
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Single nucleotide polymorphisms of the EpCAM-coding gene TACSTD1 in patients with ovarian cancer and their potential translational aspectsIn: Archives of Gynecology and Obstetrics Jg. 292 (2015) Nr. 6, S. 1367 - 1372Online Volltext: dx.doi.org/
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Dectin-1 Is Expressed in Human Lung and Mediates the Proinflammatory Immune Response to Nontypeable Haemophilus influenzaeIn: mBio Jg. 5 (2014) Nr. 5, S. e01492 - 14Online Volltext: dx.doi.org/ (Open Access)
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Eine neue Nanofaser-Matrix für den kornealen GewebeersatzIn: Klinische Monatsblätter für Augenheilkunde Jg. 231 (2014) Nr. 6, S. 626 - 630Online Volltext: dx.doi.org/
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Isoform-specific function of CEACAM1 during tumorigenesis : CEACAM1-3S, a novel prognostic biomarker in malignant melanomaIn: Experimental Dermatology Jg. 23 (2014) Nr. 3, S. E45Online Volltext: dx.doi.org/
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Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responsesIn: PLoS ONE Jg. 9 (2014) Nr. 4, S. e94106Online Volltext: dx.doi.org/ (Open Access)
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CEACAM1 Expression in Oligodendrocytes of the Developing Rat Brain Shows a Spatiotemporal Relation to Myelination and Is Altered in a Model of Encephalopathy of PrematurityIn: Developmental Neuroscience Jg. 35 (2013) Nr. 2-3, S. 226 - 240Online Volltext: dx.doi.org/
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Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae : Moraxella catarrhalis, TLR3, and type I and II interferonsIn: Respiratory Research Jg. 14 (2013) Nr. 1, S. 85Online Volltext: dx.doi.org/
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Influence of CEACAM expression in graft-versus-host disease after allogeneic transplantationIn: Bone Marrow Transplantation Jg. 48 (2013) Nr. Suppl. 2, S. S179 - S180
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Pregnancy-Specific Glycoproteins Bind Integrin αIIbβ3 and Inhibit the Platelet-Fibrinogen InteractionIn: PLoS ONE Jg. 8 (2013) Nr. 2, S. e57491Online Volltext: dx.doi.org/ (Open Access)
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Tumor and endothelial cell-derived microvesicles carry distinct CEACAMs and influence T-cell behaviorIn: PLoS ONE Jg. 8 (2013) Nr. 9, S. e74654Online Volltext: dx.doi.org/ (Open Access)
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A new tool for the transfection of corneal endothelial cells : calcium phosphate nanoparticlesIn: Acta Biomaterialia Jg. 8 (2012) Nr. 3, S. 1156 - 1163Online Volltext: dx.doi.org/
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Cold storage of rat hepatocyte suspensions for one week in a customized cold storage solution - preservation of cell attachment and metabolismIn: PLoS ONE Jg. 7 (2012) Nr. 7, S. e40444Online Volltext: dx.doi.org/ (Open Access)
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High insulin-like growth factor mRNA-binding protein 3 (IMP3) protein expression is associated with poor survival in muscle-invasive bladder cancerIn: BJU International (BJUI) Jg. 110 (2012) Nr. 6B, S. E308 - E317Online Volltext: dx.doi.org/ (Open Access)
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Influence of CEACAMs expression in graft-versus-host disease after allogeneic transplantationIn: Onkologie Jg. 35 (2012) Nr. Suppl. 6, S. 125
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Contrast-enhanced transrectal ultrasound (CE-TRUS) with cadence-contrast pulse sequence (CPS) technology for the identification of prostate cancerIn: Urologic Oncology: Seminars and Original Investigations Jg. 29 (2011) Nr. 3, S. 295 - 301Online Volltext: dx.doi.org/
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Urinary matrix metalloproteinase-7 level is associated with the presence of metastasis in bladder cancerIn: BJU International (BJUI) Jg. 107 (2011) Nr. 7, S. 1069 - 1073Online Volltext: dx.doi.org/
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870 Ceacam1 expression distinguishes indolent from lethal prostate cancerIn: European Urology Supplements Jg. 9 (2010) Nr. 2, S. 275Online Volltext: dx.doi.org/
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CEACAM1: a novel urinary marker for bladder cancer detection.In: European Urology Jg. 57 (2010) Nr. 4, S. 648 - 654Online Volltext: dx.doi.org/
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Deregulation of the CEACAM expression pattern causes undifferentiated cell growth in human lung adenocarcinoma cellsIn: PLoS ONE Jg. 5 (2010) Nr. 1, S. e8747Online Volltext: dx.doi.org/ (Open Access)
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Phosphoantigen-Stimulated γδ T Cells Suppress Natural Killer-Cell Responses to Missing-SelfIn: Cancer Immunology Research Jg. 10 (2022) Nr. 5, S. 558 - 570Online Volltext: dx.doi.org/ (Open Access)
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ASO Visual Abstract : Proof of Principle of Combining Fluorescence-Guided Surgery with Photoimmunotherapy to Improve the Outcome of Pancreatic Cancer Therapy in an Orthotopic Mouse ModelIn: Annals of Surgical Oncology Jg. 30 (2023) Nr. 1, S. 626 - 627Online Volltext: dx.doi.org/
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1384 Novel, immune agonistic CEACAM1/5 antibody (YB-200) demonstrates anti-tumor efficacy and significantly increases B-cell response in syngeneic liver Hepa1-6 tumor microenvironmentIn: Journal for ImmunoTherapy of Cancer Jg. 10 (2022) Nr. Suppl. 2,Online Volltext: dx.doi.org/ (Open Access)
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Fluorescence-guided Surgery and Adjuvant Photoimmunotherapy Using a Single Fluorescent Antibody Reduces the Frequency of Metastatic Recurrence in an Orthotopic Nude Mouse Model of Pancreatic Cancer
Society of Surgical Oncology SSO 2022 – International Conference on Surgical Cancer Care March; 9-12, 2022; Dallas, USA,In: Annals of Surgical Oncology Jg. 29 (2022) Nr. SUPPL 2, 2, SI, S. 347 - 348Online Volltext: dx.doi.org/ (Open Access) -
A Novel Imageable Patient-Derived Orthotopic Xenograft Model of Gastroesophageal Junction Adenocarcinoma Targeted with Fluorescent Antibodies to Carcinoembryonic Antigen-Related Cell Adhesion MoleculesIn: Annals of Surgical Oncology Jg. 28 (2021) Nr. Suppl. 1, S. 40
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Evaluation der CEACAM-1 Level im Serum von Schwangeren im ersten Trimester bei hohem Risiko für PräeklampsieIn: Geburtshilfe und Frauenheilkunde Jg. 80 (2020) Nr. 10, S. e151Online Volltext: dx.doi.org/
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Unaltered fungal burden and lethality in human CEACAM1-Transgenic mice during Candida albicans Dissemination and systemic infection
3rd International Symposium of the CRC/Transregio FungiNet, 16–18 September 2020, Digital, Germany,In: Mycoses Jg. 63 (2020) Nr. S1, Special Issue: Abstracts of the 54th Scientific Conference of the German speaking Mycological Society (DMykG) e. V., 3rd International Symposium of the CRC/Transregio FungiNet, 16–18 September 2020, Digital, Germany, S. 6Online Volltext: dx.doi.org/ (Open Access) -
Catch me if you can! : Novel immune escape mechanisms in melanoma metastases of the brain
45th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF) ; March 7‐10, 2018, Zürich,In: Experimental Dermatology Jg. 27 (2018) Nr. 3, S. e15Online Volltext: dx.doi.org/ (Open Access) -
Ceacam1 controls IL-2-dependent regulatory T cell induction in immune-mediated hepatitisIn: Journal of Hepatology Jg. 68 (2018) Nr. Suppl. 1, S. 448Online Volltext: dx.doi.org/
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CEACAM1 and CEACAM2 are expressed on oligodendrocytes of the developing mouse brainIn: European Journal of Pediatrics Jg. 175 (2016) Nr. 11, S. 1685 - 1685Online Volltext: dx.doi.org/
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Mechanistic analysis of CD3-driven T cell functions reveals a CD32a polymorphism associated with melanoma emergenceIn: Experimental Dermatology Jg. 24 (2015) Nr. 3, 42nd Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF), March 05-07, 2015, Ulm, Germany, S. E18 - E18Online Volltext: dx.doi.org/
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Functional Characterization and Clonal Composition of Human Post-germinal Center Memory B CellsIn: Scandinavian Journal of Immunology Jg. 80 (2014) Nr. 3: The 18th germinal centre conferenceUddevalla, SwedenSeptember 11–14, 2014, Abstracts, S. 233Online Volltext: dx.doi.org/
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Nanoparticles for delivery of therapeutical nucleic acids to corneal endotheliumIn: Acta Ophthalmologica Jg. 91 (2013) Nr. S252, Special Issue: Abstracts from the 2013 European Association for Vision and Eye Research Conference, 4234Online Volltext: dx.doi.org/
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Color-coded labeling of colon cancer liver metastasis and adjacent liver segment for image guided metastasectomy : a proof of concept review of clinical translatabilityIn: Molecular-Guided Surgery: Molecules, Devices, and Applications VIII / Molecules, Devices, and Applications VIII, 22-23 January 2022, San Francisco, California, United States & 20-24 February 2022, online / Gioux, Sylvain; Gibbs, Summer L.; Pogue, Brian W. (Hrsg.) 2022 1194306Online Volltext: dx.doi.org/
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Nanoengineered biomaterials for corneal regenerationIn: Nanoengineered biomaterials for regenerative medicine / Mozafari, Masoud; Rajadas, Jayakumar; Kaplan, David (Hrsg.) 2019, S. 379 - 415Online Volltext: dx.doi.org/
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Molekulare Mechanismen und funktionelle Bedeutung von CEACAM1 (Carcino Embryonic Antigen-related Cell Adhesion Molecule 1) als Ko-Rezeptor in immunologischen Prozessen(2011) CD-ROM
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Association between CEACAMs and hypoxia defines gastric cancer progression
AACR Annual Meeting 2021, April 10-15, 2021 and May 17-21, 2021, Philadelphia, PA, USA,In: Cancer Research Jg. 81 (2021) Nr. Suppl. 13, 1988Online Volltext: dx.doi.org/