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Dr. rer. nat. Iris Helfrich

Funktionen

  • Wiss. Mitarbeiterinnen/Mitarbeiter, Klinik für Dermatologie

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Mughal, Sadaf S.; Reiss, Yvonne; Felsberg, Jörg; Meyer, Lasse; Macas, Jadranka; Schlue, Silja; Starzetz, Tatjana; Köhrer, Karl; Fehm, Tanja; Müller, Volkmar; Lamszus, Katrin; Schadendorf, Dirk; Helfrich, Iris; Wikman, Harriet; Berghoff, Anna; Brors, Benedikt; Plate, Karl H.; Reifenberger, Guido
    Identification and characterization of tertiary lymphoid structures in brain metastases
    In: Acta Neuropathologica Communications, Jg. 13, 2025, Nr. 1, 91
    DOI (Open Access)
  • Egea‐Rodriguez, Sara; Váraljai, Renáta; Nordmann, Thierry M.; Lubis, Restuan; Philip, Manuel; Rambow, Florian; Rösch, Alexander; Flaig, Michael; Horn, Susanne; Stoll, Raphael; Zhao, Fang; Paschen, Annette; Klebl, Bert; Hickson, Ian D.; Schadendorf, Dirk; Mann, Matthias; Helfrich, Iris
    RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma
    In: Clinical and Translational Medicine, Jg. 15, 2025, Nr. 1, e70094
    DOI (Open Access)
  • Placke, Jan-Malte; Bottek, Jenny; Váraljai, Renata; Shannan, Batool; Scharfenberg, Sarah; Krisp, Christoph; Spangenberg, Philippa; Soun, Camille; Siemes, Devon; Borgards, Lars; Hoffmann, Franziska; Zhao, Fang; Paschen, Anette; Schlueter, Hartmut; von Eggeling, Ferdinand; Helfrich, Iris; Rambow, Florian; Ugurel, Selma; Tasdogan, Alpaslan; Schadendorf, Dirk; Engel, Daniel Robert; Rösch, Alexander
    Spatial proteomics reveals sirtuin 1 to be a determinant of T-cell infiltration in human melanoma
    In: British Journal of Dermatology: BJD, Jg. 192, 2025, Nr. 3, S. 481 – 491
    DOI
  • Wever, Mark J A; Scommegna, Francesca R.; Egea-Rodriguez, Sara; Dehghani-Tafti, Saba; Brandao-Neto, Jose; Poisson, Jean-François; Helfrich, Iris; Antson, Alfred A.; Rodeschini, Vincent; Bax, Ben; Roche, Didier; Sanders, Cyril M.
    Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1
    In: Nucleic Acids Research, Jg. 52, 2024, Nr. 20, S. 12616 – 12632
    DOI (Open Access)
  • Messmer, Julia M.; Thommek, Calvin; Piechutta, Manuel; Venkataramani, Varun; Wehner, Rebekka; Westphal, Dana; Schubert, Marc; Mayer, Chanté D.; Effern, Maike; Berghoff, Anna S.; Hinze, Daniel; Helfrich, Iris; Schadendorf, Dirk; Wick, Wolfgang; Hölzel, Michael; Karreman, Matthia A.; Winkler, Frank
    T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels
    In: Immunity, Jg. 57, 2024, Nr. 11, S. 2688 – 2703.e11
    DOI (Open Access)
  • Karreman, Matthia A.; Bauer, Alexander T.; Solecki, Gergely; Berghoff, Anna S.; Mayer, Chanté D; Frey, Katharina; Hebach, Nils; Feinauer, Manuel J.; Schieber, Nicole L.; Tehranian, Cedric; Mercier, Luc; Singhal, Mahak; Venkataramani, Varun; Schubert, Marc C.; Hinze, Daniel; Hölzel, Michael; Helfrich, Iris; Schadendorf, Dirk; Schneider, Stefan W.; Westphal, Dana; Augustin, Hellmut G.; Goetz, Jacky G.; Schwab, Yannick; Wick, Wolfgang; Winkler, Frank
    Active Remodeling of Capillary Endothelium via Cancer Cell-Derived MMP9 Promotes Metastatic Brain Colonization
    In: Cancer Research, Jg. 83, 2023, Nr. 8, S. 1299 – 1314
    DOI (Open Access)
  • Váraljai, Renáta; Zimmer, Lisa; Al-Matary, Yahya; Kaptein, Paulien; Albrecht, Lea J.; Shannan, Batool; Brase, Jan C.; Gusenleitner, Daniel; Amaral, Teresa; Wyss, Nina; Utikal, Jochen; Flatz, Lukas; Rambow, Florian; Reinhardt, Hans Christian; Dick, Jenny; Engel, Daniel R.; Horn, Susanne; Ugurel, Selma; Sondermann, Wiebke; Livingstone, Elisabeth; Sucker, Antje; Paschen, Annette; Zhao, Fang; Placke, Jan M.; Klose, Jasmin M.; Fendler, Wolfgang P.; Thommen, Daniela S.; Helfrich, Iris; Schadendorf, Dirk; Rösch, Alexander
    Author Correction: Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma
    In: Nature Cancer, Jg. 4, 2023, Nr. 9, S. 1395
    DOI (Open Access)
  • Cibir, Zülal; Hassel, Jacqueline; Sonneck, Justin; Kowitz, Lennart; Beer, Alexander; Kraus, Andreas; Hallekamp, Gabriel; Rosenkranz, Martin; Raffelberg, Pascal; Olfen, Sven; Smilowski, Kamil; Burkard, Roman; Helfrich, Iris; Tuz, Ali Ata; Singh, Vikramjeet; Ghosh, Susmita; Sickmann, Albert; Klebl, Anne-Kathrin; Eickhoff, Jan Eike; Klebl, Bert; Seidl, Karsten; Chen, Jianxu; Grabmaier, Anton; Viga, Reinhard; Gunzer, Matthias
    ComplexEye : a multi-lens array microscope for high-throughput embedded immune cell migration analysis
    In: Nature Communications, Jg. 14, 2023, Nr. 1, 8103
    DOI, Online Volltext (Open Access)
  • Martins Nascentes Melo, Luiza; Herrera-Rios, Dayana; Hinze, Daniel; Löffek, Stefanie; Oezel, Irem; Turiello, Roberta; Klein, Juliane; Leonardelli, Sonia; Westedt, Isa-Vanessa; Al-Matary, Yahya; Egea-Rodriguez, Sara; Brenzel, Alexandra; Bau, Maja; Sucker, Antje; Hadaschik, Eva; Wirsdörfer, Florian; Hanenberg, Helmut; Uhlenbrock, Niklas; Rauh, Daniel; Poźniak, Joanna; Rambow, Florian; Marine, Jean-Christophe; Effern, Maike; Glodde, Nicole; Schadendorf, Dirk; Jablonska, Jadwiga; Hölzel, Michael; Helfrich, Iris
    Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma
    In: Journal for ImmunoTherapy of Cancer, Jg. 11, 2023, Nr. 4, e004150
    DOI (Open Access)
  • Váraljai, Renáta; Zimmer, Lisa; Al-Matary, Yahya; Kaptein, Paulien; Albrecht, Lea J.; Shannan, Batool; Brase, Jan C.; Gusenleitner, Daniel; Amaral, Teresa; Wyss, Nina; Utikal, Jochen; Flatz, Lukas; Rambow, Florian; Reinhardt, Hans Christian; Dick, Jenny; Engel, Daniel R.; Horn, Susanne; Ugurel, Selma; Sondermann, Wiebke; Livingstone, Elisabeth; Sucker, Antje; Paschen, Annette; Zhao, Fang; Placke, Jan-Malte; Klose, Jasmin M.; Fendler, Wolfgang; Thommen, Daniela S.; Helfrich, Iris; Schadendorf, Dirk; Rösch, Alexander
    Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma
    In: Nature Cancer, Jg. 4, 2023, Nr. 9, S. 1292 – 1308
    DOI (Open Access)
  • Spangenberg, Philippa; Hagemann, Nina; Squire, Anthony; Förster, Nils; Krauß, Sascha D.; Qi, Yachao; Yusuf, Ayan Mohamud; Wang, Jing; Grüneboom, Anika; Kowitz, Lennart; Korste, Sebastian; Totzeck, Matthias; Cibir, Zülal; Tuz, Ali Ata; Singh, Vikramjeet; Siemes, Devon; Struensee, Laura; Engel, Daniel R.; Ludewig, Peter; Nascentes Melo, Luiza Martins; Helfrich, Iris; Chen, Jianxu; Gunzer, Matthias; Hermann, Dirk M.; Mosig, Axel
    Rapid and fully automated blood vasculature analysis in 3D light-sheet image volumes of different organs
    In: Cell Reports Methods, Jg. 3, 2023, Nr. 3, 100436
    DOI (Open Access)
  • Franklin, Cindy; Mohr, Peter; Bluhm, Leonie; Grimmelmann, Imke; Gutzmer, Ralf; Meier, Friedegund; Garzarolli, Marlene; Weichenthal, Michael; Pfoehler, Claudia; Herbst, Rudolf; Terheyden, Patrick; Utikal, Jochen; Ulrich, Jens; Debus, Dirk; Haferkamp, Sebastian; Kaatz, Martin; Forschner, Andrea; Leiter, Ulrike; Nashan, Dorothee; Kreuter, Alexander; Sachse, Michael; Welzel, Julia; Heinzerling, Lucie; Meiss, Frank; Weishaupt, Carsten; Gambichler, Thilo; Weyandt, Gerhard; Dippel, Edgar; Schatton, Kerstin; Celik, Eren; Trommer, Maike; Helfrich, Iris; Rösch, Alexander; Zimmer, Lisa; Livingstone, Elisabeth; Schadendorf, Dirk; Horn, Susanne; Ugurel, Selma
    Impact of radiotherapy and sequencing of systemic therapy on survival outcomes in melanoma patients with previously untreated brain metastasis : a multicenter DeCOG study on 450 patients from the prospective skin cancer registry ADOREG
    In: Journal for ImmunoTherapy of Cancer, Jg. 10, 2022, Nr. 6, e004509
    DOI (Open Access)
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander
    Persister state-directed transitioning and vulnerability in melanoma
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Nature Communications, Jg. 13, 2022, Nr. 1, S. 35 – 36
    DOI, Online Volltext (Open Access)
  • Bordbari, Sharareh; Mörchen, Britta; Pylaeva, Ekaterina; Siakaeva, Elena; Spyra, Ilona; Domnich, Maksim; Droege, Freya; Kanaan, Oliver; Lang, Karl S.; Schadendorf, Dirk; Lang, Stephan; Helfrich, Iris; Jablonska, Jadwiga
    SIRT1‐mediated deacetylation of FOXO3a transcription factor supports pro‐angiogenic activity of interferon‐deficient tumor‐associated neutrophils
    In: International Journal of Cancer, Jg. 150, 2022, Nr. 7, S. 1198 – 1211
    DOI (Open Access)
  • Michel, Lars; Helfrich, Iris; Hendgen-Cotta, Ulrike Barbara; Mincu, Raluca-Ileana; Korste, Sebastian; Mrotzek, Simone Maria; Spomer, Armin; Odersky, Andrea; Rischpler, Christoph; Herrmann, Ken; Umutlu, Lale; Coman, Cristina; Ahrends, Robert; Sickmann, Albert; Löffek, Stefanie; Livingstone, Elisabeth; Ugurel, Selma; Zimmer, Lisa; Gunzer, Matthias; Schadendorf, Dirk; Totzeck, Matthias; Rassaf, Tienush
    Targeting early stages of cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapy
    In: European Heart Journal, Jg. 43, 2022, Nr. 4, S. 316 – 329
    DOI
  • Váraljai, Renáta; Horn, Susanne; Sucker, Antje; Pierscianek, Daniela; Schmitt, Verena; Carpinteiro, Alexander; Becker, Katrin; Reifenberger, Julia; Rösch, Alexander; Felsberg, Joerg; Reifenberger, Guido; Sure, Ulrich; Schadendorf, Dirk; Helfrich, Iris
    Integrative genomic analyses of patient-matched intracranial and extracranial metastases reveal a novel brain-specific landscape of genetic variants in driver genes of malignant melanoma
    In: Cancers, Jg. 13, 2021, Nr. 4, S. 731
    DOI, Online Volltext (Open Access)
  • Saadati, Fariba; Moritz, Juliane; Berner, Julia; Freund, Eric; Miebach, Lea; Helfrich, Iris; Stoffels, Ingo; Emmert, Steffen; Bekeschus, Sander
    Patient-derived human basal and cutaneous squamous cell carcinoma tissues display apoptosis and immunomodulation following gas plasma exposure with a certified argon jet
    In: International Journal of Molecular Sciences (IJMS), Jg. 22, 2021, Nr. 21, 11446
    DOI (Open Access)
  • Franz, Matthias; Mörchen, Britta; Degenhart, Carsten; Gülden, Daniel; Shkura, Oleksandr; Wolters, Dirk; Koch, Uwe; Klebl, Bert; Stoll, Raphael; Helfrich, Iris; Scherkenbeck, Jürgen
    Sequence‐Selective Covalent CaaX‐Box Receptors Prevent Farnesylation of Oncogenic Ras Proteins and Impact MAPK/PI3 K Signaling
    In: ChemMedChem, Jg. 16, 2021, Nr. 16, S. 2504 – 2514
    DOI (Open Access)
  • Bekeschus, Sander; Moritz, Juliane; Helfrich, Iris; Boeckmann, Lars; Weltmann, Klaus-Dieter; Emmert, Steffen; Metelmann, Hans-Robert; Stoffels, Ingo; von Woedtke, Thomas
    Ex vivo exposure of human melanoma tissue to cold physical plasma elicits apoptosis and modulates inflammation
    In: Applied Sciences, Jg. 10, 2020, Nr. 6, S. 1971
    DOI (Open Access)
  • Herrera-Rios, Dayana; Mughal, Sadaf S.; Teuber-Hanselmann, Sarah; Pierscianek, Daniela; Sucker, Antje; Jansen, Philipp; Schimming, Tobias; Klode, Joachim; Reifenberger, Julia; Felsberg, Jörg; Keyvani, Kathy; Brors, Benedikt; Sure, Ulrich; Reifenberger, Guido; Schadendorf, Dirk; Helfrich, Iris
    Macrophages/microglia represent the major source of indolamine 2,3-dioxygenase expression in melanoma metastases of the brain
    In: Frontiers in Immunology, Jg. 11, 2020, Article-No: 120
    DOI, Online Volltext (Open Access)
  • Helfrich, Iris; Singer, Bernhard B.
    Size Matters: The Functional Role of the CEACAM1 Isoform Signature and Its Impact for NK Cell-Mediated Killing in Melanoma
    In: Cancers, Jg. 11, 2019, Nr. 3, S. 356
    DOI, Online Volltext (Open Access)
  • Mörchen, Britta; Shkura, Oleksandr; Stoll, Raphael; Helfrich, Iris
    Targeting the “undruggable” RAS - new strategies - new hope?
    In: Cancer Drug Resistance, Jg. 2, 2019, Nr. 3, S. 813 – 826
    DOI (Open Access)
  • Schöpel, Miriam; Shkura, Oleksandr; Seidel, Jana; Kock, Klaus; Zhong, Xueyin; Löffek, Stefanie; Helfrich, Iris; Bachmann, Hagen Sjard; Scherkenbeck, Jürgen; Herrmann, Christian; Stoll, Raphael
    Allosteric Activation of GDP-Bound Ras Isoforms by Bisphenol Derivative Plasticisers
    In: International Journal of Molecular Sciences (IJMS), Jg. 19, 2018, Nr. 4, S. 1133
    DOI (Open Access)
  • Klein, Johanna C.; Moses, Katrin; Zelinskyy, Gennadiy; Sody, Simon; Buer, Jan; Lang, Stephan; Helfrich, Iris; Dittmer, Ulf; Kirschning, Carsten Jürgen; Brandau, Sven
    Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth
    In: Nature Communications, Jg. 8, 2017, S. 14600
    DOI (Open Access)
  • Kalkavan, Halime; Sharma, Piyush; Kasper, Stefan; Helfrich, Iris; Pandyra, Aleksandra A.; Gassa, Asmae; Virchow, Isabel; Flatz, Lukas; Brandenburg, Tim; Namineni, Sukumar; Heikenwalder, Mathias; Höchst, Bastian; Knolle, Percy A.; Wollmann, Guido; Von Laer, Dorothee; Drexler, Ingo; Rathbun, Jessica; Cannon, Paula M.; Scheu, Stefanie; Bauer, Jens; Chauhan, Jagat; Häussinger, Dieter; Willimsky, Gerald; Löhning, Max; Schadendorf, Dirk; Brandau, Sven; Schuler, Martin; Lang, Philipp A.; Lang, Karl S.
    Spatiotemporally restricted arenavirus replication induces immune surveillance and type i interferon-dependent tumour regression
    In: Nature Communications, Jg. 8, 2017, S. 14447
    DOI (Open Access)
  • Rösch, Alexander; Paschen, Annette; Landsberg, Jenny; Helfrich, Iris; Becker, Jürgen; Schadendorf, Dirk
    Phenotypic tumour cell plasticity as a resistance mechanism and therapeutic target in melanoma
    In: European Journal of Cancer (EJC), Jg. 59, 2016, S. 109 – 112
    DOI
  • Carpinteiro, Alexander; Beckmann, Nadine; Seitz, Aaron; Hessler, Gabriele; Wilker, Barbara; Soddemann, Matthias; Helfrich, Iris; Edelmann, Bärbel; Gulbins, Erich; Becker, Katrin Anne
    Role of Acid Sphingomyelinase-Induced Signaling in Melanoma Cells for Hematogenous Tumor Metastasis
    In: Cellular Physiology and Biochemistry, Jg. 38, 2016, Nr. 1, S. 1 – 14
    DOI (Open Access)
  • Klose, Ralph; Krzywinska, Ewelina; Castells, Magali; Gotthardt, Dagmar; Putz, Eva Maria; Kantari-Mimoun, Chahrazade; Chikdene, Naima; Meinecke, Anna-Katharina; Schrödter, Katrin; Helfrich, Iris; Fandrey, Joachim; Sexl, Veronika; Stockmann, Christian
    Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia
    In: Nature Communications, Jg. 7, 2016, S. 12528
    DOI (Open Access)
  • Löffek, Stefanie; Franzke, Claus-Werner; Helfrich, Iris
    Tension in Cancer
    In: International Journal of Molecular Sciences (IJMS), Jg. 17, 2016, Nr. 11, S. 1910
    DOI, Online Volltext (Open Access)
  • Ullrich, Nico; Heinemann, Anja; Nilewski, Elena; Scheffrahn, Inka; Klode, Joachim; Scherag, Andre; Schadendorf, Dirk; Singer, Bernhard B.; Helfrich, Iris
    CEACAM1-3S drives melanoma cells into NK cell-mediated cytolysis and enhances patient survival
    In: Cancer Research, Jg. 75, 2015, Nr. 9, S. 1897 – 1907
    DOI (Open Access)
  • Löffek, Stefanie; Ullrich, Nico; Görgens, André; Murke, Florian; Eilebrecht, Mara; Menne, Christopher; Giebel, Bernd; Schadendorf, Dirk; Singer, Bernhard B.; Helfrich, Iris
    CEACAM1-4L promotes anchorage-independent growth in melanoma
    In: Frontiers in Oncology, Jg. 5, 2015, 234
    DOI (Open Access)
  • Stoffels, Ingo; Morscher, S.; Helfrich, Iris; Hillen, Uwe; Lehy, J.; Burton, N.; Pöppel, Thorsten; Gunzer, Matthias; Schadendorf, Dirk; Klode, Joachim
    Clinical application of noninvasive and nonradioactive determination of microscopic lymph node tumor status by multispectral optoacoustic imaging
    In: Journal of Nuclear Medicine (JNM), Jg. 56, 2015, Nr. Suppl. 3, S. 40
    Online Volltext
  • Stoffels, Ingo; Morscher, S.; Helfrich, Iris; Hillen, Uwe; Lehy, J.; Burton, N. C.; Poppel, T.; Rösch, Alexander; Griewank, Klaus; Schadendorf, Dirk; Gunzer, Matthias; Klode, Joachim
    Die multispektraloptoakustische Tomographie (MSOT) zur nichtinvasiven Diagnostik des Schildwächterlymphknotens bei Patienten mit malignem Melanom
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG), Jg. 13, 2015, Nr. 12, S. 1323
    DOI
  • Ullrich, Nico; Löffek, Stefanie; Horn, Susanne; Ennen, Marie; Sánchez‐del‐Campo, Luis; Zhao, Fang; Breitenbücher, Frank; Davidson, Irwin; Singer, Bernhard B.; Schadendorf, Dirk; Goding, Colin R.; Helfrich, Iris
    MITF is a critical regulator of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in malignant melanoma
    In: Pigment Cell and Melanoma Research, Jg. 28, 2015, Nr. 6, S. 736 – 740
    DOI
  • Stoffels, Ingo; Morscher, Stefan; Helfrich, Iris; Hillen, Uwe; Leyh, Julia; Burton, Neal C.; Sardella, Thomas C.P.; Claussen, Jing; Pöppel, Thorsten; Bachmann, Hagen Sjard; Rösch, Alexander; Griewank, Klaus; Schadendorf, Dirk; Gunzer, Matthias; Klode, Joachim
    Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging
    In: Immunotherapy, Jg. 7, 2015, Nr. 317, S. 317ra199
    DOI
  • Carpinteiro, Alexander; Becker-Flegler, Katrin; Japtok, Lukasz; Hessler, Gabriele; Keitsch, Simone; Požgajovà, Miroslava; Schmid, Kurt Werner; Adams, Constantin; Müller, Stefan; Kleuser, Burkhard; Edwards, Michael J.; Grassmé, Heike; Helfrich, Iris; Gulbins, Erich
    Regulation of hematogenous tumor metastasis by acid sphingomyelinase
    In: EMBO Molecular Medicine, Jg. 7, 2015, Nr. 6, S. 714 – 734
    DOI (Open Access)
  • Stoffels, Ingo; Gunzer, Matthias; Leyh, J.; Hillen, Uwe; Helfrich, Iris; Schadendorf, Dirk; Klode, Joachim
    Die Photooptoakustische Tomographie zur nicht invasiven und nicht radioaktiven Bestimmung des Schildwachterlymphknotenstatus bei Melanompatienten
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG), Jg. 12, 2014, Nr. Suppl. 3, S. 5 – 6
    DOI
  • Ullrich, N.; Heinemann, A.; Nilewsk, E.; Scherag, Andre; Schadendorf, Dirk; Singer, Bernhard B.; Helfrich, Iris
    Isoform-specific function of CEACAM1 during tumorigenesis : CEACAM1-3S, a novel prognostic biomarker in malignant melanoma
    In: Experimental Dermatology, Jg. 23, 2014, Nr. 3, S. E45
    DOI
  • Helfrich, Iris; Ullrich, Nico; Zigrino, Paola; Schadendorf, Dirk
    Primary tumor versus metastasis : new experimental models for studies on cancer cell homing and metastasis in melanoma
    In: Pigment Cell and Melanoma Research, Jg. 27, 2014, Nr. 2, S. 309 – 316
    DOI
  • Stockmann, Christian; Schadendorf, Dirk; Klose, Ralph; Helfrich, Iris
    The impact of the immune system on tumor : angiogenesis and vascular remodeling
    In: Frontiers in Oncology, Jg. 4, 2014, S. 69
    DOI (Open Access)
  • Bald, Tobias; Quast, Thomas; Landsberg, Jennifer; Rogava, Meri; Glodde, Nicole; Lopez-Ramos, Dorys; Kohlmeyer, Judith; Riesenberg, Stefanie; van den Boorn-Konijnenberg, Debby; Hömig-Hölzel, Cornelia; Reuten, Raphael; Schadow, Benjamin; Weighardt, Heike; Wenzel, Daniela; Helfrich, Iris; Schadendorf, Dirk; Bloch, Wilhelm; Bianchi, Marco E; Lugassy, Claire; Barnhill, Raymond L; Koch, Manuel; Fleischmann, Bernd K; Förster, Irmgard; Kastenmüller, Wolfgang; Kolanus, Waldemar; Hölzel, Michael; Gaffal, Evelyn; Tüting, Thomas
    Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma
    In: Nature, Jg. 507, 2014, Nr. 7490, S. 109 – 113
    DOI
  • Zechariah, Anil; Jin, Fengyan; Hagemann, Nina; Döppner, Thorsten R.; ElAli, Ayman; Helfrich, Iris; Mies, Günter; Hermann, Dirk M.
    Hyperlipidemia attenuates vascular endothelial growth factor-induced angiogenesis, impairs cerebral blood flow, and disturbs stroke recovery via decreased pericyte coverage of brain endothelial cells
    In: Arteriosclerosis, Thrombosis, and Vascular Biology, Jg. 33, 2013, Nr. 7, S. 1561 – 1567
    DOI
  • Hutzler, Marina; Helfrich, Iris; Schadendorf, Dirk; Buer, Jan; Hansen, Wiebke
    Neuropilin-1 is a key mediator of VEGF-dependent Treg migration to tumors
    In: International Journal of Molecular Medicine, Jg. 32, 2013, Nr. Suppl. 1, S. S36
  • Zechariah, Anil; ElAli, Ayman; Döppner, Thorsten R.; Jin, Fengyan; Hasan, Mohammad R.; Helfrich, Iris; Mies, Günter; Hermann, Dirk M.
    Vascular endothelial growth factor promotes pericyte coverage of brain capillaries, improves cerebral blood flow during subsequent focal cerebral ischemia, and preserves the metabolic penumbra
    In: Stroke, Jg. 44, 2013, Nr. 6, S. 1690 – 1697
    DOI
  • Meinecke, Anna-Katharina; Nagy, Nadine; D'Amico Lago, Gabriela; Kirmse, Santina; Klose, Ralph; Schrödter, Katrin; Zimmermann, Annika; Helfrich, Iris; Rundqvist, Helene; Theegarten, Dirk; Anhenn, Olaf; Orian-Rousseau, Véronique; Johnson, Randall S.; Alitalo, Kari; Fischer, Jens W.; Fandrey, Joachim; Stockmann, Christian
    Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis
    In: Blood, Jg. 119, 2012, Nr. 24, S. 5931 – 5942
    DOI
  • Hansen, Wiebke; Hutzler, Marina; Abel, Simone; Alter, Christina; Stockmann, Christian; Kliche, Stefanie; Albert, Juliane; Sparwasser, Tim; Sakaguchi, Shimon; Westendorf, Astrid; Schadendorf, Dirk; Buer, Jan; Helfrich, Iris
    Neuropilin 1 deficiency on CD4⁺Foxp3⁺ regulatory T cells impairs mouse melanoma growth
    In: Journal of Experimental Medicine (JEM), Jg. 209, 2012, Nr. 11, S. 2001 – 2016
    DOI (Open Access)
  • Stockmann, Christian; Kirmse, Santina; Helfrich, Iris; Weidemann, Alexander; Takeda, Norihiko; Doedens, Andrew; Johnson, Randall S.
    A wound size-dependent effect of myeloid cell-derived vascular endothelial growth factor on wound healing
    In: Journal of Investigative Dermatology, Jg. 131, 2011, Nr. 3, S. 797 – 801
    DOI (Open Access)
  • Helfrich, Iris; Schadendorf, Dirk
    Blood vessel maturation, vascular phenotype and angiogenic potential in malignant melanoma : One step forward for overcoming anti-angiogenic drug resistance?
    In: Molecular Oncology, Jg. 5, 2011, Nr. 2, S. 137 – 149
    DOI
  • Testori, Julia; Schweighofer, Bernhard; Helfrich, Iris; Sturtzel, Caterina; Lipnik, Karoline; Gesierich, Sabine; Nasarre, Patrick; Hofer-Warbinek, Renate; Bilban, Martin; Augustin, Hellmut G.; Hofer, Erhard
    The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cells
    In: Blood, Jg. 117, 2011, Nr. 9, S. 2735 – 2744
    DOI, Online Volltext (Open Access)
  • Helfrich, Iris; Scheffrahn, Inka; Bartling, Soenke; Weis, Joachim; von Felbert, Verena; Middleton, Mark; Kato, Masahi; Ergün, Süleyman; Schadendorf, Dirk
    Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma
    In: Journal of Experimental Medicine (JEM), Jg. 207, 2010, Nr. 3, S. 491 – 503
    DOI (Open Access)

    • Abstracts

  • Janicot, Michel; Rupalla, Katrin; Schmidt, Alexej; Helfrich, Iris; Singer, Bernhard B.
    1384 Novel, immune agonistic CEACAM1/5 antibody (YB-200) demonstrates anti-tumor efficacy and significantly increases B-cell response in syngeneic liver Hepa1-6 tumor microenvironment
    In: Journal for ImmunoTherapy of Cancer. London: BMJ, Jg. 10, 2022, Nr. Suppl. 2
    DOI (Open Access)
  • Placke, Jan-Malte; Bottek, J.; Váraljai, R.; Shannan, B.; Krisp, C.; Spangenberg, P.; Soun, C.; Hoffmann, F.; Zhao, F.; Paschen, Annette; Schlüter, H.; von Eggeling, F.; Helfrich, Iris; Rambow, F.; Schadendorf, Dirk; Engel, Daniel Robert; Rösch, Alexander
    Compartment-based proteomics of CD8high vs. CD8low melanoma regions reveals differential regulation of TOR signaling
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG). Hoboken: Wiley-Blackwell - STM, Jg. 20, 2022, Nr. S3, S. 12
    DOI
  • Michel, Lars; Hendgen-Cotta, Ulrike B.; Mincu, Raluca I.; Helfrich, Iris; Korste, S; Mrotzek, Simone; Rischpler, C; Herrmann, Ken; Ugurel, Selma; Zimmer, Lisa; Coman, C; Ahrends, R; Schadendorf, Dirk; Rassaf, Tienush; Totzeck, Matthias
    Preclinical and clinical assessment of immune checkpoint inhibitor-associated left ventricular dysfunction
    ESC Congress 2020 – The Digital Experience 29 August – 1 September 2020,
    In: European Heart Journal. Oxford: Oxford University Press (OUP), Jg. 41, 2020, Nr. Supplement_2, S. 3260
    DOI (Open Access)
  • Michel, Lars; Hendgen-Cotta, Ulrike B.; Mincu, Raluca I.; Helfrich, Iris; Korste, S; Mrotzek, Simone; Schadendorf, Dirk; Rassaf, Tienush; Totzeck, Matthias
    Tumor necrosis factor alpha blockade prevents immune checkpoint inhibitor therapy-related cardiotoxicity
    ESC Congress 2020 – The Digital Experience 29 August – 1 September 2020,
    In: European Heart Journal. Oxford: Oxford University Press (OUP), Jg. 41, 2020, Nr. Supplement_2, S. 3250
    DOI (Open Access)
  • Herrera-Rios, D.; Schmitt, V.; Herz, Josephine; Hinze, D.; Pierscianek, Daniela; Kato, M.; Felsberg, J.; Singer, Bernhard B.; Sure, Ulrich; Reifenberger, Guido; Schadendorf, Dirk; Holzel, M.; Helfrich, Iris
    Catch me if you can! : Novel immune escape mechanisms in melanoma metastases of the brain
    45th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF) ; March 7‐10, 2018, Zürich,
    In: Experimental Dermatology. Hoboken: Wiley, Jg. 27, 2018, Nr. 3, S. e15
    DOI (Open Access)
  • Michel, L; Hendgen-Cotta, Ulrike B.; Helfrich, Iris; Rassaf, Tienush; Totzeck, Matthias
    P6552 C57BL/6 programmed death 1 deficient mice show myocardial antibody deposits but preserved functional integrity of the cardiovascular system
    ESC Congress 2018 25 - 29 August Munich, Germany,
    In: European Heart Journal. Oxford: Oxford University Press (OUP), Jg. 39, 2018, Nr. suppl_1, S. 1399
    DOI
  • Löffek, S.; Horn, S.; Dujardin, P.; Hölzel, M.; Schadendorf, Dirk; Helfrich, Iris
    Potential role of TGF-beta signaling in immune-checkpoint-therapy-induced resistance in malignant melanoma
    45th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF) ; March 7‐10, 2018, Zürich,
    In: Experimental Dermatology. Hoboken: Wiley, Jg. 27, 2018, Nr. 3, S. e63 – e64
    DOI (Open Access)
  • Helfrich, Iris; Hansen, Wiebke; Hutzler, Marina; Sakaguchi, S.; Albert, J.; Stockmann, C.; Buer, Jan; Schadendorf, Dirk
    Neuropilin-1 Deficiency on CD4+Foxp3+Regulatory T Cells Modulates Tumor Angiogenesis and Impaires Tumor Growth in Melanoma
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG). Hoboken: Wiley-Blackwell - STM, Jg. 11, 2013, Nr. Suppl. S7, S. 30
    DOI
  • Buer, Jan; Hutzler, Marina; Helfrich, Iris; Schadendorf, Dirk; Hansen, Wiebke
    Neuropilin-1 mediates infiltration of regulatory T cells into tumors favoring immune escape
    In: European Journal of Immunology. Hoboken: Wiley, Jg. 190, 2013, S. P2063

    • Poster / Posterbeiträge

  • Chauvistre, H.; Shannan, B.; Daignault-Mill, S. M.; Ju, R. J.; Picard, D.; Egetemaier, S.; Váraljai, R.; Gibhardt, C. S.; Keminer, O.; Horn, S.; Remke, M.; Paschen, Annette; Becker, Jürgen C.; Helfrich, Iris; Gul, S.; Herlyn, M.; Bogeski, I.; Rodríguez-López, J. N.; Haass, N. K.; Schadendorf, Dirk; Rösch, Alexander
    Persister state-directed transitioning and vulnerability in melanoma
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG). Hoboken: Wiley-Blackwell - STM, Jg. 20, 2022, Nr. S3, S. 35 – 36
    DOI