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PD Dr. rer. nat. Annette Paschen

Funktionen

  • Privatdozent/in, Klinik für Dermatologie

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Crisan, Diana; Schatz, Susanne; Hainzl, Heidi; Zhao, Fang; Paschen, Annette; Crisan, Maria; Baican, Adrian; Scharffetter-Kochanek, Karin; Basu, Abhijit
    GSK3β activation is a key driver of resistance to Raf inhibition in BRAF mutant melanoma cells
    In: OncoTarget , Jg. 16 2025, S. 257 – 259
    DOI (Open Access)
  • Egea‐Rodriguez, Sara; Váraljai, Renáta; Nordmann, Thierry M.; Lubis, Restuan; Philip, Manuel; Rambow, Florian; Rösch, Alexander; Flaig, Michael; Horn, Susanne; Stoll, Raphael; Zhao, Fang; Paschen, Annette; Klebl, Bert; Hickson, Ian D.; Schadendorf, Dirk; Mann, Matthias; Helfrich, Iris
    RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma
    In: Clinical and Translational Medicine , Jg. 15 2025, Nr. 1, e70094
    DOI (Open Access)
  • Bernhardt, Melissa; Rech, Anne; Berthold, Marion; Lappe, Melina; Herbel, Jan-Niklas; Erhard, Florian; Paschen, Annette; Schilling, Bastian; Schlosser, Andreas
    SILAC-based quantification reveals modulation of the immunopeptidome in BRAF and MEK inhibitor sensitive and resistant melanoma cells
    In: Frontiers in Immunology , Jg. 15 2025, 1490821
    DOI (Open Access)
  • Stubenvoll, Antonia; Schmidt, Maria; Moeller, Johanna; Chango, Max Alexander Lingner; Schultz, Carolyn; Antoniadou, Olga; Loeffler-Wirth, Henry; Bernhart, Stephan; Große, Florian; Thier, Beatrice; Paschen, Annette; Anderegg, Ulf; Simon, Jan C.; Ziemer, Mirjana; Schoeder, Clara T.; Binder, Hans; Kunz, Manfred
    Single-cell transcriptomics and epigenomics point to CD58-CD2 interaction in controlling primary melanoma growth and immunity
    In: Cancer Communications , Jg. 45 2025, Nr. 4, S. 465 – 470
    DOI (Open Access)
  • Jansen, Philipp; Galetzka, Wolfgang; Thielmann, Carl Maximilian; Murali, Rajmohan; Zaremba-Montenari, Anne; Standl, Fabian; Lodde, Georg; Möller, Inga; Sucker, Antje; Paschen, Annette; Hadaschik, Eva; Ugurel, Selma; Zimmer, Lisa; Livingstone, Elisabeth; Schadendorf, Dirk; Stang, Andreas; Griewank, Klaus
    pTERT mutational status is associated with survival in stage IV melanoma patients receiving first-line immune therapy
    In: European Journal of Cancer (EJC) , Jg. 220 2025, 115337
    DOI (Open Access)
  • Pozniak, Joanna; Pedri, Dennis; Landeloos, Ewout; Van Herck, Yannick; Antoranz, Asier; Vanwynsberghe, Lukas; Nowosad, Ada; Roda, Niccolò; Makhzami, Samira; Bervoets, Greet; Maciel, Lucas Ferreira; Pulido-Vicuña, Carlos Ariel; Pollaris, Lotte; Seurinck, Ruth; Zhao, Fang; Flem-Karlsen, Karine; Damsky, William; Chen, Limin; Karagianni, Despoina; Cinque, Sonia; Kint, Sam; Vandereyken, Katy; Rombaut, Benjamin; Voet, Thierry; Vernaillen, Frank; Annaert, Wim; Lambrechts, Diether; Boecxstaens, Veerle; Saeys, Yvan; van den Oord, Joost; Bosisio, Francesca; Karras, Panagiotis; Shain, A. Hunter; Bosenberg, Marcus; Leucci, Eleonora; Paschen, Annette; Rambow, Florian; Bechter, Oliver; Marine, Jean-Christophe
    A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma
    In: Cell , Jg. 187 2024, Nr. 1, S. 166 – 183.e25
    DOI (Open Access)
  • Matull, Johanna; Placke, Jan-Malte; Lodde, Georg; Zaremba-Montenari, Anne; Utikal, Jochen; Terheyden, Patrick; Pföhler, Claudia; Herbst, Rudolf; Kreuter, Alexander; Welzel, Julia; Kretz, Julia; Möller, Inga; Sucker, Antje; Paschen, Annette; Livingstone, Elisabeth; Zimmer, Lisa; Hadaschik, Eva; Ugurel, Selma; Schadendorf, Dirk; Thielmann, Carl Maximilian; Griewank, Klaus
    Clinical and genetic characteristics of BAP1-mutated non-uveal and uveal melanoma
    In: Frontiers in Immunology , Jg. 15 2024, 1383125
    DOI (Open Access)
  • Lodde, Georg; Zhao, Fang; Herbst, Rudolf; Terheyden, Patrick; Utikal, Jochen; Pföhler, Claudia; Ulrich, Jens; Kreuter, Alexander; Mohr, Peter; Gutzmer, Ralf; Meier, Friedegund; Dippel, Edgar; Weichenthal, Michael; Jansen, Philipp; Kowall, Bernd; Galetzka, Wolfgang; Hörst, Fabian; Kleesiek, Jens; Hellwig, Birte; Rahnenführer, Jörg; Rajcsanyi, Luisa; Peters, Triinu; Hinney, Anke; Placke, Jan-Malte; Sucker, Antje; Paschen, Annette; Becker, Jürgen; Livingstone, Elisabeth; Zimmer, Lisa; Tasdogan, Alpaslan; Rösch, Alexander; Hadaschik, Eva; Schadendorf, Dirk; Griewank, Klaus; Ugurel, Selma
    Early versus late response to PD-1-based immunotherapy in metastatic melanoma
    In: European Journal of Cancer (EJC) , Jg. 210 2024, 114295
    DOI (Open Access)
  • Fischer, Kim Denise; Tiwari, Shashank; Thier, Beatrice; Qiu, Lin Christina; Lin, Tzu-Chen; Paschen, Annette; Imig, Jochen
    Long non-coding RNA GRASLND links melanoma differentiation and interferon-gamma response
    In: Frontiers in Molecular Biosciences , Jg. 11 2024, 1471100
    DOI (Open Access)
  • Schuler, Martin; Cuppens, Kristof; Plönes, Till; Wiesweg, Marcel; Du Pont, Bert; Hegedus, Balazs; Köster, Johannes; Mairinger, Fabian; Darwiche, Kaid; Paschen, Annette; Maes, Brigitte; Vanbockrijck, Michel; Lähnemann, David; Zhao, Fang; Hautzel, Hubertus; Theegarten, Dirk; Hartemink, Koen; Reis, Henning; Baas, Paul; Schramm, Alexander; Aigner, Clemens
    Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer : A randomized phase 2 trial
    In: Nature Medicine , Jg. 30 2024, Nr. 6, S. 1602 – 1611
    DOI (Open Access)
  • Uzuner, Hamdiye; Paschen, Annette; Schadendorf, Dirk; Köster, Johannes
    Orthanq: transparent and uncertainty-aware haplotype quantification with application in HLA-typing
    In: BMC Bioinformatics , Jg. 25 2024, Nr. 1, 240
    DOI (Open Access)
  • Jansen, Philipp; Galetzka, Wolfgang; Lodde, Georg; Standl, Fabian; Zaremba-Montenari, Anne; Herbst, Rudolf; Terheyden, Patrick; Utikal, Jochen; Pföhler, Claudia; Ulrich, Jens; Kreuter, Alexander; Mohr, Peter; Gutzmer, Ralf; Meier, Friedegund; Dippel, Edgar; Weichenthal, Michael; Placke, Jan-Malte; Landsberg, Jennifer; Möller, Inga; Sucker, Antje; Paschen, Annette; Hadaschik, Eva; Zimmer, Lisa; Livingstone, Elisabeth; Schadendorf, Dirk; Ugurel, Selma; Stang, Andreas; Griewank, Klaus
    Shortened progression free and overall survival to immune-checkpoint inhibitors in BRAF-, RAS- and NF1- (“Triple”) wild type melanomas
    In: European Journal of Cancer (EJC) , Jg. 208 2024, 114208
    DOI (Open Access)
  • Váraljai, Renáta; Zimmer, Lisa; Al-Matary, Yahya; Kaptein, Paulien; Albrecht, Lea J.; Shannan, Batool; Brase, Jan C.; Gusenleitner, Daniel; Amaral, Teresa; Wyss, Nina; Utikal, Jochen; Flatz, Lukas; Rambow, Florian; Reinhardt, Hans Christian; Dick, Jenny; Engel, Daniel R.; Horn, Susanne; Ugurel, Selma; Sondermann, Wiebke; Livingstone, Elisabeth; Sucker, Antje; Paschen, Annette; Zhao, Fang; Placke, Jan M.; Klose, Jasmin M.; Fendler, Wolfgang P.; Thommen, Daniela S.; Helfrich, Iris; Schadendorf, Dirk; Rösch, Alexander
    Author Correction: Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma
    In: Nature Cancer , Jg. 4 2023, Nr. 9, S. 1395
    DOI (Open Access)
  • Malyshkina, Anna; Brüggemann, Alicia; Paschen, Annette; Dittmer, Ulf
    Cytotoxic CD4⁺ T cells in chronic viral infections and cancer
    In: Frontiers in Immunology , Jg. 14 2023, 1271236
    DOI, Online Volltext (Open Access)
  • Philip, Manuel; Puppel, Sven Holger; Stiller, Mathias; Paschen, Annette; Rösch, Alexander; Zaremba, Anne; Schadendorf, Dirk; Horn, Susanne
    Database for queries of melanoma cohorts with molecular and clinical data
    In: Pigment Cell and Melanoma Research , Jg. 36 2023, Nr. 2, S. 252 – 258
    DOI (Open Access)
  • Stupia, Simone; Heeke, Christina; Brüggemann, Alicia; Zaremba-Montenari, Anne; Thier, Beatrice; Kretz, Julia; Sucker, Antje; Philip, Manuel; Zelinskyy, Gennadiy; Ferrone, Soldano; Rösch, Alexander; Horn, Susanne; Hadaschik, Eva; Schadendorf, Dirk; Trilling, Mirko; Dittmer, Ulf; Griewank, Klaus; Zhao, Fang; Paschen, Annette
    HLA class II loss and JAK1/2 deficiency coevolve in melanoma leading to CD4 T cell and IFNγ cross-resistance
    In: Clinical Cancer Research , Jg. 29 2023, Nr. 15, S. 2894 – 2907
    DOI
  • Váraljai, Renáta; Zimmer, Lisa; Al-Matary, Yahya; Kaptein, Paulien; Albrecht, Lea J.; Shannan, Batool; Brase, Jan C.; Gusenleitner, Daniel; Amaral, Teresa; Wyss, Nina; Utikal, Jochen; Flatz, Lukas; Rambow, Florian; Reinhardt, Hans Christian; Dick, Jenny; Engel, Daniel R.; Horn, Susanne; Ugurel, Selma; Sondermann, Wiebke; Livingstone, Elisabeth; Sucker, Antje; Paschen, Annette; Zhao, Fang; Placke, Jan-Malte; Klose, Jasmin M.; Fendler, Wolfgang; Thommen, Daniela S.; Helfrich, Iris; Schadendorf, Dirk; Rösch, Alexander
    Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma
    In: Nature Cancer , Jg. 4 2023, Nr. 9, S. 1292 – 1308
    DOI (Open Access)
  • López-Borrego, Silvia; Campos-Silva, Carmen; Sandúa, Amaia; Camino, Tamara; Téllez-Pérez, Lucía; Alegre, Estibaliz; Beneitez, Alexandra; Jara-Acevedo, Ricardo; Paschen, Annette; Pardo, María; González, Álvaro; Valés-Gómez, Mar
    MAPK inhibitors dynamically affect melanoma release of immune NKG2D-ligands, as soluble protein and extracellular vesicle-associated
    In: Frontiers in Cell and Developmental Biology , Jg. 10 2023, 1055288
    DOI (Open Access)
  • Cammann, Clemens; Kulla, Jonas; Wiebusch, Lüder; Walz, Christian; Zhao, Fang; Lowinus, Theresa; Topfstedt, Eylin; Mishra, Neha; Henklein, Petra; Bommhardt, Ursula; Bossaller, Lukas; Hagemeier, Christian; Schadendorf, Dirk; Schmidt, Boris; Paschen, Annette; Seifert, Ulrike
    Proteasome inhibition potentiates Kv1.3 potassium channel expression as therapeutic target in drug-sensitive and -resistant human melanoma cells
    In: Biomedicine & Pharmacotherapy , Jg. 168 2023, 115635
    DOI (Open Access)
  • Kropp, Korbinian N.; Fatho, Martina; Huduti, Enes; Faust, Marilena; Lübcke, Silke; Lennerz, Volker; Paschen, Annette; Theobald, Matthias; Wölfel, Thomas; Wölfel, Catherine
    Targeting the melanoma-associated antigen CSPG4 with HLA-C*07:01-restricted T-cell receptors
    In: Frontiers in Immunology , Jg. 14 2023, 1245559
    DOI (Open Access)
  • Immisch, Lena; Papafotiou, George; Gallarín Delgado, Nerea; Scheuplein, Vivian; Paschen, Annette; Blankenstein, Thomas; Willimsky, Gerald
    Targeting the recurrent Rac1P29S neoepitope in melanoma with heterologous high-affinity T cell receptors
    In: Frontiers in Immunology , Jg. 14 2023, 1119498
    DOI (Open Access)
  • Paschen, Annette; Melero, Ignacio; Ribas, Antoni
    Central Role of the Antigen-Presentation and Interferon-γ Pathways in Resistance to Immune Checkpoint Blockade
    In: Annual Review of Cancer Biology , Jg. 6 2022, S. 85 – 102
    DOI (Open Access)
  • Albrecht, Lea Jessica; Höwner, Anna; Griewank, Klaus; Lueong, Smiths S.; von Neuhoff, Nils; Horn, Peter; Sucker, Antje; Paschen, Annette; Livingstone, Elisabeth; Ugurel, Selma; Zimmer, Lisa; Horn, Susanne; Siveke, Jens; Schadendorf, Dirk; Váraljai, Renáta; Rösch, Alexander
    Circulating cell‐free messenger RNA enables non‐invasive pan‐tumour monitoring of melanoma therapy independent of the mutational genotype
    In: Clinical and Translational Medicine , Jg. 12 2022, Nr. 11, e1090
    DOI, Online Volltext (Open Access)
  • Thielmann, Carl Maximilian; Matull, Johanna; Roth, Sebastian; Placke, Jan-Malte; Chorti, Eleftheria; Zaremba, Anne; Lodde, Georg; Jansen, Philipp; Krefting, Frederik; Kretz, Julia; Möller, Inga; Sucker, Antje; Paschen, Annette; Livingstone, Elisabeth; Zimmer, Lisa; Ugurel, Selma; Schadendorf, Dirk; Hadaschik, Eva; Griewank, Klaus
    Genetic and Clinical Characteristics of ARID1A Mutated Melanoma Reveal High Tumor Mutational Load without Implications on Patient Survival
    In: Cancers , Jg. 14 2022, Nr. 9, 2090
    DOI, Online Volltext (Open Access)
  • Zaremba, Anne; Jansen, Philipp; Murali, Rajmohan; Mayakonda, Anand; Riedel, Anna; Krahl, Dieter; Burkhardt, Hans; John, Stefan; Géraud, Cyrill; Philip, Manuel; Kretz, Julia; Möller, Inga; Stadtler, Nadine; Sucker, Antje; Paschen, Annette; Ugurel, Selma; Zimmer, Lisa; Livingstone, Elisabeth; Horn, Susanne; Plass, Christoph; Schadendorf, Dirk; Hadaschik, Eva; Lutsik, Pavlo; Griewank, Klaus
    Genetic and Methylation Analysis of CTNNB1 in Benign and Malignant Melanocytic Lesions
    In: Cancers , Jg. 14 2022, Nr. 17, 4066
    DOI, Online Volltext (Open Access)
  • Zaremba-Montenari, Anne; Jansen, Philipp; Murali, Rajmohan; Mayakonda, Anand; Riedel, Anna; Philip, Manuel; Rose, Christian; Schaller, Jörg; Müller, Hansgeorg; Kutzner, Heinz; Möller, Inga; Stadtler, Nadine; Kretz, Julia; Sucker, Antje; Bankfalvi, Agnes; Livingstone, Elisabeth; Zimmer, Lisa; Horn, Susanne; Paschen, Annette; Plass, Christoph; Schadendorf, Dirk; Hadaschik, Eva; Lutsik, Pavlo; Griewank, Klaus
    Genetic and methylation profiles distinguish benign, malignant and spitzoid melanocytic tumors
    In: International Journal of Cancer , Jg. 151 2022, Nr. 9, S. 1542 – 1554
    DOI (Open Access)
  • Thier, Beatrice; Zhao, Fang; Stupia, Simone; Brüggemann, Alicia; Koch, Johannes; Schulze, Nina; Horn, Susanne; Coch, Christoph; Hartmann, Gunther; Sucker, Antje; Schadendorf, Dirk; Paschen, Annette
    Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicity
    In: Journal for ImmunoTherapy of Cancer , Jg. 10 2022, Nr. 6, e003863
    DOI (Open Access)
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander
    Persister state-directed transitioning and vulnerability in melanoma
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Nature Communications , Jg. 13 2022, Nr. 1, S. 35 – 36
    DOI, Online Volltext (Open Access)
  • Cheung, Phyllis F.; Yang, JiaJin; Fang, Rui; Borgers, Arianna; Krengel, Kirsten; Stoffel, Anne; Althoff, Kristina; Yip, Chi Wai; Siu, Elaine H. L.; Ng, Linda W. C.; Lang, Karl S.; Cham, Lamin B.; Engel, Daniel Robert; Soun, Camille; Cima, Igor; Scheffler, Björn; Striefler, Jana K.; Sinn, Marianne; Bahra, Marcus; Pelzer, Uwe; Oettle, Helmut; Markus, Peter; Smeets, Esther M. M.; Aarntzen, Erik H. J. G.; Savvatakis, Konstantinos; Liffers, Sven-Thorsten; Lueong, Smiths S.; Neander, Christian; Bazarna, Anna; Zhang, Xin; Paschen, Annette; Crawford, Howard C.; Chan, Anthony W. H.; Cheung, Siu Tim; Siveke, Jens
    Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression
    In: Nature Communications , Jg. 13 2022, Nr. 1, 156
    DOI (Open Access)
  • Thielmann, Carl Maximilian; Matull, Johanna; Zaremba, Anne; Murali, Rajmohan; Chorti, Eleftheria; Lodde, Georg; Jansen, Philipp; Herbst, Rudolf; Terheyden, Patrick; Utikal, Jochen; Pföhler, Claudia; Ulrich, Jens; Kreuter, Alexander; Mohr, Peter; Gutzmer, Ralf; Meier, Friedegund; Dippel, Edgar; Weichenthal, Michael; Kretz, Julia; Möller, Inga; Sucker, Antje; Paschen, Annette; Livingstone, Elisabeth; Zimmer, Lisa; Hadaschik, Eva; Ugurel, Selma; Schadendorf, Dirk; Griewank, Klaus G.
    TERT promoter mutations are associated with longer progression-free and overall survival in patients with BRAF-mutant melanoma receiving BRAF and MEK inhibitor therapy
    In: European Journal of Cancer (EJC) , Jg. 161 2022, S. 99 – 107
    DOI (Open Access)
  • Strobel, Sophia B.; Machiraju, Devayani; Hülsmeyer, Ingrid; Becker, Jürgen; Paschen, Annette; Jäger, Dirk; Wels, Winfried S.; Bachmann, Michael; Hassel, Jessica C.
    Expression of potential targets for cell-based therapies on melanoma cells
    In: Life , Jg. 11 2021, Nr. 4, S. 269
    DOI (Open Access)
  • Jansen, Philipp; Müller, Hansgeorg; Lodde, Georg C.; Zaremba, Anne; Möller, Inga; Sucker, Antje; Paschen, Annette; Esser, Stefan; Schaller, Jörg; Gunzer, Matthias; Standl, Fabian; Bauer, Sebastian; Schadendorf, Dirk; Mentzel, Thomas; Hadaschik, Eva; Griewank, Klaus G.
    GNA14, GNA11, and GNAQ Mutations Are Frequent in Benign but Not Malignant Cutaneous Vascular Tumors
    In: Frontiers in Genetics , Jg. 12 2021, 663272
    DOI, Online Volltext (Open Access)
  • Thier, Beatrice; Paschen, Annette
    Innate RIG-I signaling restores antigen presentation in tumors and overcomes T cell resistance
    In: Cell Stress: The Journal of the European Research Institute for Integrated Cellular Pathology , Jg. 5 2021, Nr. 2, S. 26 – 28
    DOI (Open Access)
  • Harbers, Franziska Noelle; Thier, Beatrice; Stupia, Simone; Zhu, Si; Schwamborn, Marion; Peller, Vicky; Chauvistré, Heike; Crivello, Pietro; Fleischhauer, Katharina; Rösch, Alexander; Sucker, Antje; Schadendorf, Dirk; Chen, Yong; Paschen, Annette; Zhao, Fang
    Melanoma Differentiation Trajectories Determine Sensitivity Toward Pre-Existing CD8⁺ Tumor-Infiltrating Lymphocytes
    In: Journal of Investigative Dermatology , Jg. 141 2021, Nr. 10, S. 2480 – 2489
    DOI (Open Access)
  • Zaremba, Anne; Lodde, Georg; Murali, Rajmohan; Philip, Manuel; Cosgarea, Ioana; Jansen, Philipp; Chorti, Eleftheria; Rose, Christian; Hemmerlein, Bernhard; Matull, Johanna; Thielmann, Carl Maximilian; Kretz, Julia; Möller, Inga; Sucker, Antje; Paschen, Annette; Livingstone, Elisabeth; Zimmer, Lisa; Horn, Susanne; Schadendorf, Dirk; Hadaschik, Eva; Griewank, Klaus
    Molecular pathology as a diagnostic aid in difficult-to-classify melanocytic tumours with spitzoid morphology
    In: European Journal of Cancer (EJC) , Jg. 148 2021, S. 340 – 347
    DOI (Open Access)
  • Thielmann, Carl Maximilian; Chorti, Eleftheria; Matull, Johanna; Murali, Rajmohan; Zaremba-Montenari, Anne; Lodde, Georg; Jansen, Philipp; Richter, Luisa; Kretz, Julia; Möller, Inga; Sucker, Antje; Herbst, Rudolf; Terheyden, Patrick; Utikal, Jochen; Pföhler, Claudia; Ulrich, Jens; Kreuter, Alexander; Mohr, Peter; Gutzmer, Ralf; Meier, Friedegund; Dippel, Edgar; Weichenthal, Michael; Paschen, Annette; Livingstone, Elisabeth; Zimmer, Lisa; Schadendorf, Dirk; Hadaschik, Eva; Ugurel, Selma; Griewank, Klaus
    NF1-mutated melanomas reveal distinct clinical characteristics depending on tumour origin and respond favourably to immune checkpoint inhibitors
    In: European Journal of Cancer (EJC) , Jg. 159 2021, S. 113 – 124
    DOI
  • Váraljai, Renáta; Elouali, S.; Lueong, Smiths S.; Wistuba-Hamprecht, Kilian; Seremet, Teofila C.; Siveke, Jens; Becker, Jürgen; Sucker, Antje; Paschen, Annette; Horn, Peter; Neyns, Bart; Weide, Benjamin M.; Schadendorf, Dirk; Rösch, Alexander
    The predictive and prognostic significance of cell-free DNA concentration in melanoma
    In: Journal of the European Academy of Dermatology and Venereology , Jg. 35 2021, Nr. 2, S. 387 – 395
    DOI (Open Access)
  • Bhat, Hilal; Zaun, Gregor; Hamdan, Thamer A.; Lang, Judith; Adomati, Tom; Schmitz, Rosa; Friedrich, Sarah-Kim; Bergerhausen, Michael; Cham, Lamin B.; Li, Fanghui; Ali, Murtaza; Zhou, Fan; Khairnar, Vishal; Duhan, Vikas; Brandenburg, Tim; Machlah, Yara Maria; Schiller, Maximilian; Berry, Arshia; Xu, Haifeng; Vollmer, Jörg; Häussinger, Dieter; Thier, Beatrice; Pandyra, Aleksandra A.; Schadendorf, Dirk; Paschen, Annette; Schuler, Martin; Lang, Philipp A.; Lang, Karl S.
    Arenavirus Induced CCL5 Expression Causes NK Cell-Mediated Melanoma Regression
    In: Frontiers in Immunology , Jg. 11 2020, S. 1849
    DOI, Online Volltext (Open Access)
  • Liu, David; Schilling, Bastian; Liu, Derek; Sucker, Antje; Livingstone, Elisabeth; Jerby-Arnon, Livnat; Zimmer, Lisa; Gutzmer, Ralf; Satzger, Imke; Loquai, Carmen; Grabbe, Stephan; Vokes, Natalie; Margolis, Claire A.; Conway, Jake; He, Meng Xiao; Elmarakeby, Haitham; Dietlein, Felix; Miao, Diana; Tracy, Adam; Gogas, Helen; Goldinger, Simone M.; Utikal, Jochen; Blank, Christian U.; Rauschenberg, Ricarda; von Bubnoff, Dagmar; Krackhardt, Angela; Weide, Benjamin; Haferkamp, Sebastian; Kiecker, Felix; Izar, Ben; Garraway, Levi; Regev, Aviv; Flaherty, Keith; Paschen, Annette; Van Allen, Eliezer M.; Schadendorf, Dirk
    Author Correction: Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
    In: Nature Medicine , Jg. 26 2020, Nr. 7, S. 1147
    DOI (Open Access)
  • David, Paul; Drabczyk-Pluta, Malgorzata; Pastille, Eva; Knuschke, Torben; Werner, Tanja; Honke, Nadine; Megger, Dominik A.; Akhmetzyanova, Ilseyar; Shaabani, Namir; Eyking-Singer, Annette; Cario, Elke; Kershaw, Olivia; Gruber, Achim D.; Tenbusch, Matthias; Dietze, Kirsten; Trilling, Mirko; Liu, Jia; Schadendorf, Dirk; Streeck, Hendrik; Lang, Karl S.; Xie, Youhua; Zimmer, Lisa; Sitek, Barbara; Paschen, Annette; Westendorf, Astrid; Dittmer, Ulf; Zelinskyy, Gennadiy
    Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology
    In: PLoS Pathogens , Jg. 16 2020, Nr. 3, e1008340
    DOI (Open Access)
  • Textoris-Taube, Kathrin; Cammann, Clemens; Henklein, Petra; Topfstedt, Eylin; Ebstein, Frédéric; Henze, Sarah; Liepe, Juliane; Zhao, Fang; Schadendorf, Dirk; Dahlmann, Burkhardt; Uckert, Wolfgang; Paschen, Annette; Mishto, Michele; Seifert, Ulrike
    ER-aminopeptidase 1 determines the processing and presentation of an immunotherapy-relevant melanoma epitope
    In: European Journal of Immunology , Jg. 50 2020, Nr. 2, S. 270 – 283
    DOI (Open Access)
  • Ugurel, Selma; Schadendorf, Dirk; Horny, K.; Sucker, Antje; Schramm, Sabine; Utikal, Jochen; Pföhler, Claudia; Herbst, Rudolf A.; Schilling, B.; Blank, Christian U.; Becker, Jürgen; Paschen, Annette; Zimmer, Lisa; Livingstone, Elisabeth; Horn, Peter; Rebmann, Vera
    Elevated baseline serum PD-1 or PD-L1 predicts poor outcome of PD-1 inhibition therapy in metastatic melanoma
    In: Annals of Oncology , Jg. 31 2020, Nr. 1, S. 144 – 152
    DOI (Open Access)
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  • Eberle, J.; Spangler, B.; Becker, J. C.; Heinemann, S. H.; Klein, C. A.; Kunz, M.; Kuphal, S.; Langer, P.; Mauch, C.; Meierjohann, S.; Paschen, Annette; Schadendorf, Dirk; Schartl, M.; Schittek, B.; Schönherr, R.; Tüting, T.; Zigrino, P.; Bosserhoff, A. K.
    Multicentre study on standardisation of melanoma cell culture : An initiative of the German Melanoma Research Network
    In: Pigment Cell and Melanoma Research , Jg. 23 2010, Nr. 2, S. 296 – 298
    DOI
  • Osen, W.; Soltek, S.; Song, M.; Leuchs, B.; Steitz, J.; Tüting, T.; Eichmüller, S. B.; Nguyen, X. D.; Schadendorf, Dirk; Paschen, Annette
    Screening of Human Tumor Antigens for CD4+ T Cell Epitopes by Combination of HLA-Transgenic Mice, Recombinant Adenovirus and Antigen Peptide Libraries
    In: PLoS ONE , Jg. 5 2010, Nr. 11, S. e14137
    DOI (Open Access)

    • Abstracts

  • Rodriguez, S. Egea; Varaljai, R.; Philip, M.; Rambow, F.; Rösch, Alexander; Zhao, F.; Paschen, Annette; Schadendorf, Dirk
    RECQL4-mediated Downregulation of MHC Class II promotes Immune Evasion and reduced Anti-PD-1 Response in Melanoma Patients
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 22 2024, Nr. Suppl. 4, S. 6
    DOI
  • Crisan, D.; Scharffetter-Kochanek, K.; Zhao, F.; Paschen, Annette; Schatz, S.; Hainz, H.; Crisan, M.; Basu, A.; Sindrilaru, A.
    GSK3-beta activation is a key driver of resistance to RAF inhibition in BRAF mutant melanoma cells
    In: Experimental Dermatology , Jg. 32 2023, Nr. 4, S. e30
  • Jansen, Philipp; Galetzka, W.; Lodde, Georg C.; Zaremba, Anne; Standl, F.; Landsberg, J.; Herbst, R.; Terheyden, P.; Utikal, J. S.; Pföhler, C.; Ulrich, J.; Placke, Jan-Malte; Kreuter, A.; Mohr, P.; Gutzmer, R.; Meier, F.; Dippel, E.; Weichenthal, M.; Möller, I.; Sucker, A.; Paschen, Annette; Hadaschik, Eva; Livingstone, Elisabeth; Zimmer, Lisa; Schadendorf, Dirk; Ugurel, Selma; Stang, Andreas; Griewank, Klaus
    Molekulare und klinische Charakterisierung von BRAF/NRAS/NF1-wt Melanomen
    33. Deutscher Hautkrebskongress (ADO-Jahrestagung) ; 06.–09. September 2023, Hamburg, Germany,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 21 2023, Nr. S4, Special Issue: Abstractband anlässlich des 33. Deutschen Hautkrebskongresses (ADO‐Jahrestagung) 06.–09. September 2023 Hamburg, S. 21
    DOI (Open Access)
  • Lodde, Georg C.; Zhao, F.; Galetzka, W.; Placke, Jan-Malte; Griewank, Klaus; Herbst, R.; Terheyden, P.; Utikal, J. S.; Pföhler, C.; Ulrich, J.; Kreuter, A.; Mohr, P.; Gutzmer, R.; Meier, F.; Dippel, E.; Weichenthal, M.; Sucker, A.; Paschen, Annette; Horn, S.; Jansen, Philipp; Becker, Jürgen C.; Livingstone, Elisabeth; Zimmer, Lisa; Hadaschik, Eva; Schadendorf, Dirk; Ugurel, Selma
    Untersuchung des klinischen Verlaufs von Melanompatienten mit einer Super-Response (CR/PR innerhalb von 3 Monaten) unter PD-1-basierter Immuncheckpoint-Inhibition : eine Subgruppen-Analyse der prospektiven multizentrischen Studie ADOREG
    33. Deutscher Hautkrebskongress (ADO-Jahrestagung) ; 06.–09. September 2023, Hamburg, Germany,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 21 2023, Nr. S4, Special Issue: Abstractband anlässlich des 33. Deutschen Hautkrebskongresses (ADO‐Jahrestagung) 06.–09. September 2023 Hamburg, S. 8 – 9
    DOI (Open Access)
  • Ramirez Valladolid, S.; Hinze, D.; Zhao, F.; Paschen, Annette; Hölzel, M.
    Using CRISPitope (CRISPR-assisted insertion of epitopes) to study T cell responses against human melanoma cells
    In: Experimental Dermatology 2023, S. e102
  • Placke, Jan-Malte; Bottek, J.; Váraljai, R.; Shannan, B.; Krisp, C.; Spangenberg, P.; Soun, C.; Hoffmann, F.; Zhao, F.; Paschen, Annette; Schlüter, H.; von Eggeling, F.; Helfrich, Iris; Rambow, F.; Schadendorf, Dirk; Engel, Daniel Robert; Rösch, Alexander
    Compartment-based proteomics of CD8high vs. CD8low melanoma regions reveals differential regulation of TOR signaling
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 20 2022, Nr. S3, S. 12
    DOI
  • Albrecht, L. J.; Höwner, A.; Griewank, Klaus; Lueong, S. S.; von Neuhoff, N.; Horn, Peter A.; Sucker, A.; Paschen, Annette; Livingstone, Elisabeth; Ugurel, Selma; Zimmer, Lisa; Horn, S.; Siveke, Jens T.; Schadendorf, Dirk; Váraljai, R.; Rösch, Alexander
    Im Plasma zirkulierende zellfreie mRNA ermöglicht die minimal-invasive und Genotyp-unabhängige Therapieüberwachung bei Patienten mit Melanom
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 20 2022, Nr. S3, S. 12 – 13
    DOI
  • Thier, B.; Such, L.; Peller, V.; Schwamborn, M.; Sucker, A.; Coch, C.; Schadendorf, Dirk; Griewank, Klaus; Trilling, Mirko; Zhao, F.; Paschen, Annette
    Interferon-independent enhancement of melanoma cell immunogenicity by RIG-I activation
    47th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF) Virtual, March 04‐06, 2021,
    In: Experimental Dermatology , Jg. 30 2021, Nr. 3, S. E78
  • Thier, B.; Zhao, F.; Horn, S.; Coch, C.; Hartmann, G.; Schadendorf, Dirk; Paschen, Annette
    Intratumoral Immunotherapy : RIG-I Agonists induce a dedifferentiated yet T-Cell-sensitive Melanoma Cell Phantotype
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 19 2021, Nr. Suppl. 4, S. 34
  • Zhao, F.; Peller, V.; Schwamborn, M.; Kwapik, S.; Sucker, A.; Ugurel, Selma; Schadendorf, Dirk; Paschen, Annette
    Profiling of tumor-infiltrating T cells for guidance of melanoma salvage therapy in immune-checkpoint-blockade resistant patients
    47th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF) Virtual, March 04‐06, 2021,
    In: Experimental Dermatology , Jg. 30 2021, Nr. 3, S. E52
    DOI
  • Thielmann, Carl Maximilian; Matull, J.; Zaremba, Anne; Chorti, E.; Lodde, Georg; Jansen, Philipp; Kretz, J.; Möller, I.; Sucker, A.; Paschen, Annette; Livingstone, Elisabeth; Zimmer, Lisa; Hadaschik, Eva; Ugurel, Selma; Schadendorf, Dirk; Griewank, Klaus
    TERT Promoter Mutations associated with longer progression-free and Overall Survival under BRAF/MEK Therapy
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 19 2021, Nr. Suppl. 4, S. 31
  • Zhao, F.; Harbers, Franziska; Thier, Beatrice; Stupia, Simone; Zhu, S.; Schwamborn, Marion; Peller, Vladimir; Chauvistre, Heike; Rösch, Alexander; Sucker, Antje; Schadendorf, Dirk; Paschen, Annette
    Distinct melanoma differentiation trajectories driven by MAPKi associate with activation of CD8+tumor-infiltrating lymphocytes
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 18 2020, Nr. Suppl. 2: Special Issue: Abstractband anlässlich des 30. Deutschen Hautkrebskongresses (ADO‐Jahrestagung) 09.–12. September 2020, S. FV17
    DOI (Open Access)
  • Thier, B.; Such, L.; Schwamborn, M.; Sucker, A.; Coch, C.; Schadendorf, Dirk; Griewank, Klaus; Trilling, Mirko; Zhao, F.; Paschen, Annette
    RIG-I activation enhances melanoma immunogenicity and improves anti-tumor T cell responses in combination with anti-PD-1 immune checkpoint blocking antibodies
    In: Journal for ImmunoTherapy of Cancer , Jg. 8 2020, Nr. Suppl. 2, S. A3
    DOI (Open Access)
  • Thier, Beatrice; Such, Lina; Sucker, Antje; Coch, Carla; Hartmann, G.; Schadendorf, Dirk; Griewank, Klaus; Trilling, Mirko; Zhao, F.; Paschen, Annette
    Tumorzell‐intrinsiche Aktivierung des Immunrezeptors RIG‐I in Kombination mit Immun‐Checkpoint‐Blockade verbessert anti‐Tumor T‐Zellantworten
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 18 2020, Nr. Suppl. 2: Special Issue: Abstractband anlässlich des 30. Deutschen Hautkrebskongresses (ADO‐Jahrestagung) 09.–12. September 2020, S. FV18
    DOI (Open Access)
  • Haupert, V.; Fatho, M.; Kulka, K.; Wölfel, C.; Paschen, Annette; Wehler, D.; Theobald, M.; Lennerz, V.; Wölfel, T.
    Impact of T cells transduced with an HLA-independent T-cell receptor (TCR) against the alpha chain of the GM-CSF receptor (CSF2RA) on hematopoietic progenitor cells
    Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, 11. - 14. Oktober 2019, Berlin, Germany,
    In: Oncology Research and Treatment , Jg. 42 2019, Nr. Supplement 4: Abstracts, S. 99
    DOI (Open Access)
  • Pieper, N.; Zaremba, Anne; Harbers, F. N.; Schwamborn, M.; Lübcke, S.; Schrörs, B.; Sucker, A.; Lennerz, V.; Wölfel, T.; Schadendorf, Dirk; Paschen, Annette; Zhao, F.
    Evolution of cross‐resistance to CD8+ T cells in the course of BRAF and MEK inhibitor treatment in BRAFV600E melanoma
    28. Deutschen Hautkrebskongresses (ADO‐Jahrestagung); 13.–15. September 2018; Stuttgart,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 16 2018, Nr. 6, S. 53
    DOI (Open Access)

    • Preprints

  • Wagner, Jessica; Feller, Konstantina; Schrenke, Nicole; Schulze, Nina; Paschen, Annette; Dehmelt, Leif; Nalbant, Perihan
    Optogenetic stimulation of Lbc GEF-mediated Rho activity dynamics promotes cell invasion
    2025
    DOI (Open Access)
  • Egetemaier, Stefanie; Chauvistré, Heike; Váraljai, Renáta; Hua, Yichao; Lueong, Smiths; Makhzami, Samira; Srinivas, Nalini; Forster, Jan; Ullrich, Vivien; Stupia, Simone; Schroeder, Valéria; Scharfenberg, Sarah; Hoewner, Anna; Shannan, Batool; Siveke, Jens; Baietti, Maria Francesca; Leucci, Eleonora; Marine, Jean-Christophe; Paschen, Annette; Scheffler, Björn; Engel, Daniel R.; Becker, Lisa; Nensa, Felix; Köster, Johannes; Grünwald, Barbara; Poepsel, Simon; Ninck, Sabrina; Kaschani, Farnusch; Schadendorf, Dirk; Becker, Jürgen; Tasdogan, Alpaslan; Rambow, Florian; Rösch, Alexander
    Redirecting resistance evolution in BRAFV600 melanoma by inhibition of the peroxiredoxin-thioredoxin system
    2025
    DOI (Open Access)

    • Beiträge in Sammelwerken und Tagungsbänden

  • Paschen, Annette; Schadendorf, Dirk
    The era of checkpoint inhibition : Lessons learned from melanoma
    In: Current Immunotherapeutic Strategies in Cancer / Theobald, Matthias (Hrsg.) 2020, S. 169 – 187
    DOI

    • Poster / Posterbeiträge

  • Zhao, F.; Thier, B.; Kwapik, S.; Laudage, M.; Griewank, Klaus; Nalbant, Perihan; Rambow, F.; Sucker, A.; Schadendorf, Dirk; Paschen, Annette
    Role of IFNγ-induced tumor-T cell equilibrium in melanoma latency
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 21 2023, Nr. S4, Special Issue: Abstractband anlässlich des 33. Deutschen Hautkrebskongresses (ADO‐Jahrestagung) 06.–09. September 2023 Hamburg, S. 34
    DOI (Open Access)
  • Zaremba, Anne; Jansen, Philipp; Murali, R.; Mayakonda, A.; Riedel, A.; Krahl, D.; Burkhardt, H.; John, S.; Géraud, C.; Philip, M.; Kretz, J.; Möller, I.; Stadtler, N.; Sucker, A.; Paschen, Annette; Ugurel, Selma; Zimmer, Lisa; Livingstone, Elisabeth; Horn, S.; Plass, C.; Schadendorf, Dirk; Hadaschik, Eva; Lutsik, P.; Griewank, Klaus
    Genetic and methylation analysis of CTNNB1 mutations in benign and malignant melanocytic lesions
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 20 2022, Nr. S3, S. 84
    DOI
  • Navarro Ocon, Alba; Cabo Zabala, Laura; Brinkmann, Berit; Lopez Sanchez, Alberto; Paschen, Annette; Garrido, Federico; Ruiz Cabello, Francisco; Aptsiauri, Natalia
    Liquid biopsy for the detection of HLA-I alterations in cancer
    Joint 35th European Immunogenetics and Histocompatibility Conference; May 17–20, 2022; Amsterdam, the Netherlands,
    In: HLA: Immune Response Genetics (Human Leukocyte Antigens) , Jg. 99 2022, Nr. 5, SI, S. 430
  • Jansen, P.; Zaremba, Anne; Philip, M.; Lodde, Georg; Livingstone, Elisabeth; Zimmer, Lisa; Ugurel, Selma; Paschen, Annette; Sucker, A.; Möller, I.; Landsberg, J.; Rose, C.; Emberger, M.; Schaller, J.; Plass, C.; Hadaschik, Eva; Schadendorf, Dirk; Mentzel, T.; Lutsik, P.; Griewank, Klaus
    Molekularpathologie und Methylierungsprofile als diagnostische Unterstützung zur Differenzierung von Klarzellsarkomen und melanozytären Tumoren
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 20 2022, Nr. S3, S. 88
    DOI
  • Chauvistre, H.; Shannan, B.; Daignault-Mill, S. M.; Ju, R. J.; Picard, D.; Egetemaier, S.; Váraljai, R.; Gibhardt, C. S.; Keminer, O.; Horn, S.; Remke, M.; Paschen, Annette; Becker, Jürgen C.; Helfrich, Iris; Gul, S.; Herlyn, M.; Bogeski, I.; Rodríguez-López, J. N.; Haass, N. K.; Schadendorf, Dirk; Rösch, Alexander
    Persister state-directed transitioning and vulnerability in melanoma
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 20 2022, Nr. S3, S. 35 – 36
    DOI