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Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Implanted Carbon Nanotubes Harvest Electrical Energy from Heartbeat for Medical ImplantsIn: Advanced Materials Jg. 36 (2024) Nr. 32, 2313688Online Volltext: dx.doi.org/ (Open Access)
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Regional wall motion abnormalities on focused transthoracic echocardiography in patients presenting with acute chest pain : a predefined post hoc analysis of the prospective single-centre observational EPIC-ACS studyIn: BMJ Open Jg. 14 (2024) Nr. 9, e085677Online Volltext: dx.doi.org/ (Open Access)
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BNP and NT-proBNP Thresholds for the Assessment of Prognosis in Patients Without Heart FailureIn: JACC: Advances Jg. 2 (2023) Nr. 10, 100688Online Volltext: dx.doi.org/ (Open Access)
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Central extracorporeal circulatory life support (cECLS) in selected patients with critical cardiogenic shockIn: Frontiers in Cardiovascular Medicine Jg. 10 (2023) 1142953Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Epicardial adipose tissue and obstructive coronary artery disease in acute chest pain : The EPIC-ACS studyIn: European Heart Journal Open Jg. 3 (2023) Nr. 3, oead041Online Volltext: dx.doi.org/ (Open Access)
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Virtual reality-assisted distraction during transcatheter aortic valve implantation under local anaesthesia : A randomised studyIn: International Journal of Cardiology Jg. 387 (2023) 131130Online Volltext: dx.doi.org/
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Defining the optimal revascularization strategy during protected high-risk procedures with ImpellaIn: European Heart Journal Supplements Jg. 24 (2022) Nr. Supplement J, S. J25 - J29Online Volltext: dx.doi.org/ (Open Access)
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Diagnostic accuracy of coronary computed tomography angiography-derived fractional flow reserve (CT-FFR) in patients before liver transplantation using CT-FFR machine learning algorithmIn: European Radiology Jg. 32 (2022) Nr. 12, S. 8761 - 8768Online Volltext: dx.doi.org/ (Open Access)
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Embolic Protection with the TriGuard 3 System in Nonagenarian Patients Undergoing Transcatheter Aortic Valve Replacement for Severe Aortic StenosisIn: Journal of Clinical Medicine (JCM) Jg. 11 (2022) Nr. 7, 2003Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Epicardial fat and incident heart failure with preserved ejection fraction in patients with coronary artery diseaseIn: International Journal of Cardiology Jg. 357 (2022) S. 140 - 145Online Volltext: dx.doi.org/
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Standardized pre-procedural clinical workup for protected percutaneous coronary interventionIn: European Heart Journal Supplements Jg. 24 (2022) Nr. Supplement J, S. J11 - J16Online Volltext: dx.doi.org/ (Open Access)
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The Transaxillary Approach via Prosthetic Conduit for Transcatheter Aortic Valve Replacement With the New-Generation Balloon-Expandable Valves in Patients With Severe Peripheral Artery DiseaseIn: Frontiers in Cardiovascular Medicine Jg. 8 (2022) 795263Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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What is known in pre-, peri-, and post-procedural anticoagulation in micro-axial flow pump protected percutaneous coronary intervention?In: European Heart Journal Supplements Jg. 24 (2022) Nr. Supplement J, S. J17 - J24Online Volltext: dx.doi.org/ (Open Access)
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Assessment of coronary artery disease during hospitalization for cancer treatmentIn: Clinical Research in Cardiology Jg. 110 (2021) Nr. 2, S. 200 - 210Online Volltext: dx.doi.org/ (Open Access)
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Epicardial adipose tissue differentiates in patients with and without coronary microvascular dysfunctionIn: International Journal of Obesity Jg. 45 (2021) Nr. 9, S. 2058 - 2063Online Volltext: dx.doi.org/ (Open Access)
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Implications of alterations in pre-test probability in the 2019 update of ESC guidelines for chronic coronary syndromes on diagnostic accuracy of pharmacological stress-echocardiography : A retrospective cohort studyIn: Journal of Cardiovascular Imaging Jg. 29 (2021) Nr. 2, S. 160 - 165Online Volltext: dx.doi.org/ (Open Access)
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Utilization of IVUS improves all-cause mortality in patients undergoing invasive coronary angiography : IVUS-utilization and long-term survivalIn: Atherosclerosis Plus Jg. 43 (2021) S. 10 - 17Online Volltext: dx.doi.org/ (Open Access)
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Anemia increases long-term mortality in patients undergoing conventional coronary angiography – the ECAT registry
ESC Congress 2020 – The Digital Experience 29 August – 1 September 2020,In: European Heart Journal Jg. 41 (2020) Nr. Supplement_2, S. 1508Online Volltext: dx.doi.org/ -
Association of echocardiographic measures of left ventricular diastolic dysfunction and hypertrophy with presence of coronary microvascular dysfunctionIn: International Journal of Cardiology (IJC) Heart & Vasculature Jg. 27 (2020) S. 100493Online Volltext: dx.doi.org/ (Open Access)
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Global longitudinal strain is associated with better outcomes in transcatheter aortic valve replacementIn: BMC Cardiovascular Disorders Jg. 20 (2020) Nr. 1, 267Online Volltext: dx.doi.org/ (Open Access)
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Impact of Bioprosthetic Choice on Mortality After Transfemoral Transcatheter Aortic Valve Implantation in Patients With Reduced Versus Preserved Left-Ventricular Ejection FractionIn: The American Journal of Cardiology Jg. 125 (2020) Nr. 10, S. 1550 - 1557Online Volltext: dx.doi.org/
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Impact of Diabetes Mellitus on Outcomes after High-Risk Interventional Coronary ProceduresIn: Journal of Clinical Medicine (JCM) Jg. 9 (2020) Nr. 11, 3414Online Volltext: dx.doi.org/ (Open Access)
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Impact of left-ventricular end-diastolic pressure as a predictor of periprocedural hemodynamic deterioration in patients undergoing Impella supported high-risk percutaneous coronary interventionsIn: International Journal of Cardiology (IJC) Heart & Vasculature Jg. 26 (2020) S. 100445Online Volltext: dx.doi.org/ (Open Access)
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Safety and efficacy of a novel algorithm to guide decision-making in high-risk interventional coronary proceduresIn: International Journal of Cardiology Jg. 299 (2020) S. 87 - 92Online Volltext: dx.doi.org/
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Six months follow-up of protected high-risk percutaneous coronary intervention with the microaxial Impella pump : results from the German Impella registryIn: Coronary Artery Disease Jg. 31 (2020) Nr. 3, S. 237 - 242Online Volltext: dx.doi.org/
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Treatment patterns of lipid-lowering therapy in patients with coronary artery disease aged above and below 75 Years : A retrospective cross-sectional study of 1500 patients in a tertiary care referral center in GermanyIn: Drugs & Aging Jg. 37 (2020) Nr. 7, S. 521 - 527Online Volltext: dx.doi.org/ (Open Access)
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Troponins and Natriuretic Peptides in Cardio-Oncology Patients—Data From the ECoR RegistryIn: Frontiers in Pharmacology Jg. 11 (2020) S. 740Online Volltext: dx.doi.org/ (Open Access)
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Troponins and brain natriuretic peptides for the prediction of cardiotoxicity in cancer patients : a meta-analysisIn: European Journal of Heart Failure Jg. 22 (2020) Nr. 2, S. 350 - 361Online Volltext: dx.doi.org/ (Open Access)
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Access site complications following Impella-supported high-risk percutaneous coronary interventionsIn: Scientific Reports Jg. 9 (2019) Nr. 1, S. 17844Online Volltext: dx.doi.org/ (Open Access)
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Disconcordance between ESC prevention guidelines and observed lipid profiles in patients with known coronary artery diseaseIn: International Journal of Cardiology (IJC) Heart & Vasculature Jg. 22 (2019) S. 73 - 77Online Volltext: dx.doi.org/ (Open Access)
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Impact of baseline left ventricular ejection fraction on outcome after transfemoral transcatheter aortic valve implantation in patients with and without low-gradient aortic stenosisIn: Echocardiography Jg. 36 (2019) Nr. 1, S. 28 - 37Online Volltext: dx.doi.org/
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Correction: Expertenkonsensus zum praktischen Einsatz von Herzkreislaufunterstützungssystemen bei Hochrisiko-KoronarinterventionenIn: Der Kardiologe Jg. 12 (2018) Nr. 1, S. 83Online Volltext: dx.doi.org/ (Open Access)
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Indication and short-term clinical outcomes of high-risk percutaneous coronary intervention with microaxial Impella® pump : results from the German Impella® registryIn: Clinical Research in Cardiology Jg. 107 (2018) Nr. 8, S. 653 - 657Online Volltext: dx.doi.org/
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Expertenkonsensus zum praktischen Einsatz von Herzkreislaufunterstützungssystemen bei Hochrisiko‑KoronarinterventionenIn: Der Kardiologe Jg. 11 (2017) Nr. 6, S. 460 - 472Online Volltext: dx.doi.org/ (Open Access)
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Impact of liver indicators on clinical outcome in patients undergoing transcatheter aortic valve implantationIn: The Annals of Thoracic Surgery Jg. 104 (2017) Nr. 4, S. 1357 - 1364Online Volltext: dx.doi.org/
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No protection of heart, kidneys and brain by remote ischemic preconditioning before transfemoral transcatheter aortic valve implantation : Interim-analysis of a randomized single-blinded, placebo-controlled, single-center trialIn: International Journal of Cardiology Jg. 231 (2017) S. 248 - 254Online Volltext: dx.doi.org/
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Transfemoral transcatheter aortic valve implantation in patients with end-stage renal disease and kidney transplant recipientsIn: Scientific Reports Jg. 7 (2017) Nr. 1, 14397Online Volltext: dx.doi.org/ (Open Access)
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Protected percutaneous coronary intervention - a new road for success in treating complex patientsIn: Advances in Interventional Cardiology Jg. 12 (2016) Nr. 3, S. 200 - 202Online Volltext: dx.doi.org/ (Open Access)
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Quantification and characterisation of released plaque material during bioresorbable vascular scaffold implantation into right coronary artery lesions by multimodality intracoronary imagingIn: EuroIntervention Jg. 12 (2016) Nr. 12, S. 1481 - 1489Online Volltext: dx.doi.org/ (Open Access)
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Risk Assessment of Patients Undergoing Transfemoral Aortic Valve Implantation upon Admission for Post-Interventional Intensive Care and Surveillance : Implications on Short- and Midterm OutcomesIn: PLoS ONE Jg. 11 (2016) Nr. 11, e0167072Online Volltext: dx.doi.org/ (Open Access)
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Conventional aortic valve replacement or transcatheter aortic valve implantation in patients with previous cardiac surgeryIn: Journal of Cardiology Jg. 66 (2015) Nr. 4, S. 292 - 297Online Volltext: dx.doi.org/ (Open Access)
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How should i treat a significant and inoperable left main coronary atherosclerotic disease (LMCAD) in the setting of a severely depressed left ventricular systolic function and severe aorto-iliac atherosclerotic disease?In: EuroIntervention Jg. 11 (2015) Nr. 5, S. 605 - 608Online Volltext: dx.doi.org/
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Intraaortic protection from embolization in patients undergoing transaortic transcatheter aortic valve implantationIn: The Annals of Thoracic Surgery Jg. 100 (2015) Nr. 2, S. 686 - 691Online Volltext: dx.doi.org/
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Low incidence of paravalvular leakage with the balloon-expandable sapien 3 transcatheter heart valveIn: The Annals of Thoracic Surgery Jg. 100 (2015) Nr. 3, S. 819 - 825Online Volltext: dx.doi.org/
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Outcome in TAVI patients with symptomatic aortic stenosis not fulfilling PARTNER study inclusion criteriaIn: Catheterization and Cardiovascular Interventions Jg. 86 (2015) Nr. 6, S. 1097 - 1104Online Volltext: dx.doi.org/
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Rebuttal : Should the distal landing zone be assessed in thoracic endovascular aortic repair?In: Catheterization and Cardiovascular Interventions Jg. 85 (2015) Nr. 5, S. 934 - 935Online Volltext: dx.doi.org/
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Thoracic aortic aneurysm expansion due to late distal stent graft-induced new entryIn: Catheterization and Cardiovascular Interventions Jg. 85 (2015) Nr. 2, S. E43 - E53Online Volltext: dx.doi.org/
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Tools & Techniques - clinical : percutaneous catheter-based left ventricular support using the Impella CPIn: EuroIntervention Jg. 10 (2015) Nr. 10, S. 1247 - 1249Online Volltext: dx.doi.org/
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A novel calcium scoring system accurately predicts likelihood and location of post-TAVI paravalvular leakIn: Journal of Cardiovascular Surgery Jg. 55 (2014) Nr. 3, S. 423 - 433
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Comparison Between Different Risk Scoring Algorithms on Isolated Conventional or Transcatheter Aortic Valve ReplacementIn: The Annals of Thoracic Surgery Jg. 97 (2014) Nr. 3, S. 796 - 802Online Volltext: dx.doi.org/
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Transapical Transcatheter Aortic Valve for Severe Aortic Regurgitation : Expanding the LimitsIn: JACC Cardiovascular Interventions Jg. 7 (2014) Nr. 10, S. 1159 - 1167Online Volltext: dx.doi.org/ (Open Access)
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A New self-expandable transcatheter aortic valve for transapical implantation : Feasibility in acute and chronic animal experimentsIn: Scandinavian Cardiovascular Journal Jg. 47 (2013) Nr. 3, S. 145 - 153Online Volltext: dx.doi.org/
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Correction: Preparatory Balloon Aortic Valvuloplasty During Transcatheter Aortic Valve Implantation for Improved Valve SizingIn: JACC Cardiovascular Interventions Jg. 6 (2013) Nr. 10, S. 1110Online Volltext: dx.doi.org/
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Elevated plasma B-type natriuretic peptide level predicts 30-day and 1-year mortality after transapical but not transfemoral transcatheter aortic valve implantationIn: European Heart Journal Jg. 34 (2013) Nr. Suppl. 1, S. 399
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Hemodynamic assessment of paravalvular aortic regurgitation after TAVI : Estimated myocardial supply-demand ratio and cardiovascular mortalityIn: American Journal of Physiology: Heart and Circulatory Physiology Jg. 304 (2013) Nr. 7, S. H1023 - H1028Online Volltext: dx.doi.org/ (Open Access)
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Incidence, outcome and correlates of residual paravalvular aortic regurgitation after transcatheter aortic valve implantation and importance of haemodynamic assessmentIn: EuroIntervention Jg. 8 (2013) Nr. 12, S. 1398 - 1406Online Volltext: dx.doi.org/
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Incidence, predictors, origin and prevention of early and late neurological events after transcatheter aortic valve implantation (TAVI) : a comprehensive review of current dataIn: Journal of Thrombosis and Thrombolysis Jg. 35 (2013) Nr. 4, S. 436 - 449Online Volltext: dx.doi.org/
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Preparatory balloon aortic valvuloplasty during transcatheter aortic valve implantation for improved valve sizingIn: JACC Cardiovascular Interventions Jg. 6 (2013) Nr. 9, S. 965 - 971Online Volltext: dx.doi.org/ (Open Access)
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Response to Letters Regarding Article, "Cerebral Embolization During Transcatheter Aortic Valve Implantation: A Transcranial Doppler Study"In: Circulation Jg. 127 (2013) Nr. 18, S. e591 - e592Online Volltext: dx.doi.org/
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Risk factors for thrombus formation on the amplatzer cardiac plug after left atrial appendage occlusionIn: JACC Cardiovascular Interventions Jg. 6 (2013) Nr. 6, S. 606 - 613Online Volltext: dx.doi.org/
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Suture-mediated arterial access site closure after transfemoral aortic valve implantationIn: Catheterization and Cardiovascular Interventions Jg. 81 (2013) Nr. 2, S. E139 - E150Online Volltext: dx.doi.org/
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Cerebral embolization during transcatheter aortic valve implantation : A transcranial doppler studyIn: Circulation Jg. 126 (2012) Nr. 10, S. 1245 - 1255Online Volltext: dx.doi.org/
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Effect of Transfemoral Aortic Valve Implantation on Plasma Brain Natriuretic Peptide Levels and Its Predictive Value for 30-day and 1-year survivalIn: Journal of the American College of Cardiology Jg. 60 (2012) Nr. Suppl. 17, S. B238
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Effect of transfemoral aortic valve implantaion (TF-AVI) for severe aortic stenosis on plasma brain natriuretic peptide (BNP) levels : predictive value for 30-days and 1-year survivalIn: European Heart Journal Jg. 33 (2012) Nr. Suppl. 1, S. 716 - 717
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Follow-up of patients with permanent pacemaker implantation after transcatheter aortic valve implantation : Is there still need for pacing?In: Medizinische Klinik - Intensivmedizin und Notfallmedizin Jg. 107 (2012) Nr. 4, S. 328 - 329
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Hemodynamic assessment of residual paravalvular aortic regurgitation after TAVI : impact of pressure difference (Diastolic Aortic Pressure-LVEDP) and myocardial supply-demand ratio on survivalIn: European Heart Journal Jg. 33 (2012) Nr. Suppl. 1, S. 194
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Relation of Aortic Regurgitation (AR) to Plasma Brain Natriuretic Peptide (BNP) evolution after Transfemoral Aortic Valve Implantation (TAVI) for Severe Aortic Stenosis (AS)In: European Heart Journal Jg. 33 (2012) Nr. Suppl. 1, S. 716
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Results of Transfemoral Aortic Valve Implantation (TF-TAVI) performed by External Cardiologists in Collaboration with an Experienced Multidisciplinary Heart Team at a Specialized CenterIn: Journal of the American College of Cardiology Jg. 60 (2012) Nr. Suppl. 17, S. B253Online Volltext: dx.doi.org/
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Results of transfemoral TAVI in Partner-like Patients - A comparison with Real-World PatientsIn: Journal of the American College of Cardiology Jg. 60 (2012) Nr. Suppl. 17, S. B252Online Volltext: dx.doi.org/
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Transcatheter Aortic Valve Implantation (TAVI) : a 5-Year single-center experienceIn: European Heart Journal Jg. 33 (2012) Nr. Suppl. 1, S. 967
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Transient Increase in Pressure Gradients After Termination of Dual Antiplatelet Therapy in a Patient After Transfemoral Aortic Valve ImplantationIn: Circulation: Cardiovascular Interventions Jg. 5 (2012) Nr. 2, S. 318 - 320Online Volltext: dx.doi.org/
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Silent and apparent cerebral ischemia after percutaneous transfemoral aortic valve implantation : A diffusion-weighted magnetic resonance imaging studyIn: Circulation Jg. 121 (2010) Nr. 7, S. 870 - 878Online Volltext: dx.doi.org/
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Mechanical Circulatory Support Using Impella 5.5 for Patients Presented with Ischemic Heart Disease and Severely Impaired Left Ventricular Function Undergoing Coronary Artery Bypass Surgery : A Three-Year Single Centre ExperienceIn: The Journal of Heart and Lung Transplantation Jg. 42 (2023) Nr. 4, S. S406 - S406
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Screening for occult transthyretin amyloidosis in patients with degenerative aortic stenosis and amyloid red-flagsIn: European Journal of Heart Failure Jg. 25 (2023) Nr. Suppl. 2, S. 359 - 359
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BNP/ NT-pro BNP thresholds for the assessment of the prognosis in patients without heart failureIn: European Heart Journal Jg. 42 (2021) Nr. Supplement_1, ehab724.2504Online Volltext: dx.doi.org/ (Open Access)
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Epicardial adipose tissue and culprit lesions in acute chest pain : The EPIC-ACS studyIn: European Heart Journal Jg. 42 (2021) Nr. Supplement_1, ehab724.1169Online Volltext: dx.doi.org/ (Open Access)
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Positive family history of premature coronary artery disease and long-term mortality in patients undergoing conventional coronary angiography : The ECAD registryIn: European Heart Journal Jg. 42 (2021) Nr. Supplement_1, ehab724.2459Online Volltext: dx.doi.org/ (Open Access)
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Regional wall motion abnormalities predict culprit lesions in patients presenting with acute chest painIn: European Heart Journal Jg. 42 (2021) Nr. Supplement_1, ehab724.1398Online Volltext: dx.doi.org/ (Open Access)
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Very low high-density lipoprotein-cholesterol and long-term mortalityIn: European Heart Journal Jg. 42 (2021) Nr. Supplement_1, ehab724.2572Online Volltext: dx.doi.org/ (Open Access)
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Higher BNP/NT-proBNP levels stratify prognosis in patients with coronary artery disease but without heart failure
ESC Congress 2020 – The Digital Experience 29 August – 1 September 2020,In: European Heart Journal Jg. 41 (2020) Nr. Supplement_2, S. 1335Online Volltext: dx.doi.org/ -
P5377Disconcordance between ESC prevention guidelines and observed lipid profiles in patients with known coronary artery disease
ESC Congress 2018 25 - 29 August Munich, Germany,In: European Heart Journal Jg. 39 (2018) Nr. suppl_1, S. 1102Online Volltext: dx.doi.org/ -
Quantification and characterization of released plaque material during implantation of bioabsorbable vascular scaffolds into right coronary artery lesions - a multimodality intracoronary imaging study
Twenty-Seventh Annual Transcatheter Cardiovascular Therapeutics Symposium, October 11-15, 2015, San Francisco, CA, USA,In: Journal of the American College of Cardiology (JACC) Jg. 66 (2015) Nr. 15, Supplement, S. B145Online Volltext: dx.doi.org/ (Open Access) -
Coronary Microcirculation during Transfemoral Transcatheter Aortic Valve Implantation
Twenty-Sixth Annual Symposium Transcatheter Cardiovascular Therapeutics (TCT), TCT2014, 13-17 September 2014, Washington, DC, USA,In: Journal of the American College of Cardiology (JACC) Jg. 64 (2014) Nr. 11, Supplement, S. B210 - B211Online Volltext: dx.doi.org/ (Open Access) -
Coronary Microembolization during Transfemoral Transcatheter Aortic Valve Implantation : An Intracoronary Doppler Study
Twenty-Sixth Annual Symposium Transcatheter Cardiovascular Therapeutics (TCT), TCT2014, 13-17 September 2014, Washington, DC, USA,In: Journal of the American College of Cardiology (JACC) Jg. 64 (2014) Nr. 11, Supplement, S. B226Online Volltext: dx.doi.org/ (Open Access) -
Mobile aortic valve deposits - a risk factor for periprocedural stroke during transfemoral TAVI?
ESC Congress 2014, Barcelona, Spain, 30 August – 3 September 2014,In: European Heart Journal Jg. 35 (2014) Nr. Suppl. 1, S. 891Online Volltext: dx.doi.org/ -
Leveraging Preparatory Balloon Aortic Valvuloplasty (BAV) During TAVI for Improved Valve Sizing : A simple way to reduce Paravalvular Aortic Regurgitation (PAR)?!In: Journal of the American College of Cardiology / Transcatheter Cardiovascular Therapeutics Twenty-Fourth Annual Symposium (TCT); 22-26 October 2012; Miami, USA Jg. 60 (2012) S. B252Online Volltext: dx.doi.org/ (Open Access)
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TCT-874 Hemodynamic Assessment of Residual Paravalvular Aortic Regurgitation (PAR) after TAVI : Impact of Myocardial Supply-Demand Ratio (DPTI:SPTI) on SurvivalIn: Journal of the American College of Cardiology / Transcatheter Cardiovascular Therapeutics Twenty-Fourth Annual Symposium (TCT); 22-26 October 2012; Miami, USA Jg. 60 (2012) Nr. 17, Supplement, S. B253Online Volltext: dx.doi.org/ (Open Access)
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"Periprozeduales Management bei kardialen Hochrisiko-Interventionen"Duisburg ; Essen (2020) 1 CD-ROM
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TCT-776: Outcome of Residual Paravalvular Aortic Regurgitation (PAR) After Transfemoral Aortic Valve Implantation (TAVI) And Importance of Hemodynamic Assessment [Posterabstract]
TCT 2011 - Transcatheter Cardiovascular Therapeutics 23rd Annual Scientific Symposium, 7-11 November 2011, San Francisco, USA,In: Journal of the American College of Cardiology (JACC) Jg. 58 (2011) Nr. 20 Supplement, S. B206 - B207Online Volltext: dx.doi.org/ (Open Access) -
Transient increase in pressure gradient after TAVI : A question of dual antiplatelet therapy?
TCT 2011 - Transcatheter Cardiovascular Therapeutics 23rd Annual Scientific Symposium, 7-11 November 2011, San Francisco, USA,In: Journal of the American College of Cardiology (JACC) Jg. 58 (2011) Nr. 20 Supplement, S. B211Online Volltext: dx.doi.org/