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Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Amphisome plays a role in HBV production and release through the endosomal and autophagic pathwaysIn: Hepatology Communications , Jg. 9 2025, Nr. 4, e0654DOI (Open Access)
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Hepatitis B surface antigen expression impairs endoplasmic reticulum stress-related autophagic flux by decreasing LAMP2In: JHEP Reports , Jg. 6 2024, Nr. 4, 101012DOI, Online Volltext (Open Access)
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EGF receptor modulates HEV entry in human hepatocytesIn: Hepatology , Jg. 77 2023, Nr. 6, S. 2104 – 2117DOI (Open Access)
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Janus kinase-inhibition modulates hepatitis E virus infectionIn: Antiviral Research , Jg. 217 2023, 105690DOI (Open Access)
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Nuclear translocation of YAP drives BMI1-associated hepatocarcinogenesis in hepatitis B virus infectionIn: Liver International , Jg. 43 2023, Nr. 9, S. 2002 – 2016DOI (Open Access)
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Poly(I:C) Induces Distinct Liver Cell Type-Specific Responses in Hepatitis B Virus-Transgenic Mice In Vitro, but Fails to Induce These Signals In VivoIn: Viruses , Jg. 15 2023, Nr. 5, 1203DOI (Open Access)
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Retraction Note: Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathwayIn: Signal Transduction and Targeted Therapy , Jg. 8 2023, Nr. 1, 181DOI (Open Access)
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Tg1.4HBV-s-rec mice, a crossbred hepatitis B virus-transgenic model, develop mild hepatitisIn: Scientific Reports , Jg. 13 2023, Nr. 1, 22829DOI, Online Volltext (Open Access)
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A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy functionIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Jg. 119 2022, Nr. 34, e2202653119DOI (Open Access)
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Antiviral Toll-like Receptor Signaling in Non-Parenchymal Liver Cells Is Restricted to TLR3In: Viruses , Jg. 14 2022, Nr. 2, 218DOI (Open Access)
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Human hepatocyte-enriched miRNA-192-3p promotes HBV replication through inhibiting Akt/mTOR signalling by targeting ZNF143 in hepatic cell linesIn: Emerging Microbes & Infections , Jg. 11 2022, Nr. 1, S. 616 – 628DOI (Open Access)
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Interferon Alpha Induces Cellular Autophagy and Modulates Hepatitis B Virus ReplicationIn: Frontiers in Cellular and Infection Microbiology , Jg. 12 2022, 804011DOI, Online Volltext (Open Access)
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Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis CIn: JCI Insight , Jg. 7 2022, Nr. 2, e155432DOI (Open Access)
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Controversial: Early Innate Responses to Hepatitis B Virus Infection, an Explanation for Viral Persistence?In: Virologica Sinica , Jg. 36 2021, Nr. 1, S. 163 – 166DOI (Open Access)
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HBeAg induces liver sinusoidal endothelial cell activation to promote intrahepatic CD8 T cell immunity and HBV clearanceIn: Cellular & Molecular Immunology , Jg. 18 2021, Nr. 11, S. 2572 – 2574DOI (Open Access)
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Hepatitis B virus rigs the cellular metabolome to avoid innate immune recognitionIn: Nature Communications , Jg. 12 2021, Nr. 1, S. 98DOI (Open Access)
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Hippo Pathway Counter-Regulates Innate Immunity in Hepatitis B Virus InfectionIn: Frontiers in Immunology , Jg. 12 2021, 684424DOI, Online Volltext (Open Access)
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In Vivo Mouse Models for Hepatitis B Virus Infection and Their ApplicationIn: Frontiers in Immunology , Jg. 12 2021, 766534DOI, Online Volltext (Open Access)
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Initial hepatitis c virus infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- And antiviral elementsIn: Journal of Virology , Jg. 95 2021, Nr. 10, S. e00245 – 21DOI (Open Access)
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The impact of hepatitis B surface antigen on natural killer cells in patients with chronic hepatitis B virus infectionIn: Liver International , Jg. 41 2021, Nr. 9, S. 2046 – 2058DOI (Open Access)
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Transcriptome-wide analysis of human liver reveals age-related differences in the expression of select functional gene clusters and evidence for a ppp1r10-governed ‘aging cascade’In: Pharmaceutics , Jg. 13 2021, Nr. 12, 2009DOI (Open Access)
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9-PAHSA prevents mitochondrial dysfunction and increases the viability of steatotic hepatocytesIn: International Journal of Molecular Sciences (IJMS) , Jg. 21 2020, Nr. 21, S. 8279DOI, Online Volltext (Open Access)
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AMPK and Akt/mTOR signalling pathways participate in glucose-mediated regulation of hepatitis B virus replication and cellular autophagyIn: Cellular Microbiology , Jg. 22 2020, Nr. 2, S. e13131DOI (Open Access)
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Autoimmune hepatitis induction can occur in the liverIn: Liver International , Jg. 40 2020, Nr. 2, S. 377 – 381DOI (Open Access)
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C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelleIn: Journal of Hepatology , Jg. 73 2020, Nr. 3, S. 549 – 558DOI (Open Access)
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Hepatitis B Virus Particles Activate Toll-Like Receptor 2 Signaling Initially Upon Infection of Primary Human HepatocytesIn: Hepatology , Jg. 72 2020, Nr. 3, S. 829 – 844DOI (Open Access)
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Major Vault Protein Promotes Hepatocellular Carcinoma Through Targeting Interferon Regulatory Factor 2 and Decreasing p53 ActivityIn: Hepatology , Jg. 72 2020, Nr. 2, S. 518 – 534
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O-GlcNAcylation modulates HBV replication through regulating cellular autophagy at multiple levelsIn: The FASEB Journal , Jg. 34 2020, Nr. 11, S. 14473 – 14489DOI (Open Access)
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Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological ProcessesIn: Cells , Jg. 9 2020, Nr. 4, 1003DOI (Open Access)
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Recent advances in the discovery and development of TLR ligands as novel therapeutics for chronic HBV and HIV infectionsIn: Expert Opinion on Drug Discovery , Jg. 13 2018, Nr. 7, S. 661 – 670
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TLR2 stimulation strengthens intrahepatic myeloid-derived cell-mediated T cell tolerance through inducing kupffer cell expansion and IL-10 productionIn: The Journal of Immunology (JI) , Jg. 200 2018, Nr. 7, S. 2341 – 2351DOI (Open Access)
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Elevated expression of chemokine CXCL13 in chronic hepatitis B patients links to immune control during antiviral therapyIn: Frontiers in Immunology , Jg. 8 2017, S. 323DOI (Open Access)
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Hepatic expression of oncogenes Bmi1 and Dkk1 can be induced by treatment with hepatitis B virus particles or Lipopolysaccharide in vitro and is up-regulated in liver biopsies of patients with chronic HBV infectionIn: Journal of Hepatology , Jg. 66 2017, Nr. 1, S. S700
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Hepatic expression of oncogenes Bmi1 and Dkk1 is up-regulated in hepatitis B virus surface antigen–transgenic mice and can be induced by treatment with HBV particles or lipopolysaccharides in vitroIn: International Journal of Cancer , Jg. 141 2017, Nr. 2, S. 354 – 363
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Inducible Rubicon facilitates viral replication by antagonizing interferon productionIn: Cellular & Molecular Immunology , Jg. 14 2017, Nr. 7, S. 607 – 620DOI (Open Access)
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Nucleic acid-based polymers effective against hepatitis B Virus infection in patients don't harbor immunostimulatory properties in primary isolated liver cellsIn: Scientific Reports , Jg. 7 2017, S. 43838DOI (Open Access)
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Hepatic expression of proteasome subunit alpha type-6 is upregulated during viral hepatitis and putatively regulates the expression of ISG15 ubiquitin-like modifier, a proviral host gene in hepatitis C virus infectionIn: Journal of Viral Hepatitis , Jg. 23 2016, Nr. 5, S. 375 – 386
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Hepatitis B virus genome replication triggers toll-like receptor 3-dependent interferon responses in the absence of hepatitis B surface antigenIn: Scientific Reports , Jg. 6 2016, S. 24865DOI (Open Access)
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All-In-One : Advanced preparation of Human Parenchymal and Non-Parenchymal Liver CellsIn: PLoS ONE , Jg. 10 2015, Nr. 9, S. e0138655DOI (Open Access)
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Antiviral activity of human Kupffer cells, liver sinusoidal endothelial cells and hepatic stellate cells against Hepatitis C virus is restricted to toll-like receptor 3 stimulation and involves type I interferonsIn: Journal of Viral Hepatitis , Jg. 22 2015, Nr. S2, S. 71 – 72
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Antiviral activity of human non-parenchymal liver cells is restricted to toll-like receptor 3 and involves type I interferonsIn: Journal of Hepatology , Jg. 62 2015, Nr. Suppl. 2, S. 587
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Hepatic expression of proteasome subunit alpha type-6 is upregulated during viral hepatitis and putatively regulates the expression of proviral host genes in hepatitis C virus infectioIn: Journal of Viral Hepatitis , Jg. 22 2015, Nr. S 2, S. 71
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Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infectionIn: Journal of Hepatology , Jg. 62 2015, Nr. Suppl. 2, S. 583 – S583
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Set7 facilitates hepatitis C virus replication via enzymatic activity-dependent attenuation of the IFN-related pathwayIn: The Journal of Immunology (JI) , Jg. 194 2015, Nr. 6, S. 2757 – 2768DOI (Open Access)
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The hepatitis B virus (HBV) surface antigen (HBsAg) prevents hepadnaviral replication-dependent interferon responses, which are mediated by non-parenchymal liver cells in a HBV transgenic mouse modelIn: Journal of Viral Hepatitis , Jg. 22 2015, Nr. S2, S. 29 – 30
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The hepatitis B virus (HBV) surface antigen impedes hepadnaviral replication-dependent interferon responses in a HBV transgenic mouse modelIn: Journal of Hepatology , Jg. 62 2015, Nr. Suppl. 2, S. 286
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Therapeutic Antiviral Effect of the Nucleic Acid Polymer REP 2055 against Persistent Duck Hepatitis B Virus InfectionIn: PLoS ONE , Jg. 10 2015, Nr. 11, S. e0140909DOI (Open Access)
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Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitroIn: International Immunology , Jg. 26 2014, Nr. 1, S. 35 – 46
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Intrahepatic B-cell follicles of chronically hepatitis C virus-infected individuals lack signs of an ectopic germinal center reactionIn: European Journal of Immunology , Jg. 44 2014, Nr. 6, S. 1842 – 1850
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KIR2DL3+NKG2A− natural killer cells are associated with protection from productive hepatitis C virus infection in people who inject drugsIn: Journal of Hepatology , Jg. 61 2014, Nr. 3, S. 475 – 481
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Long-term stimulation of Toll-like receptor 3 in primary human hepatocytes leads to sensitization for antiviral responses induced by poly I : C treatmentIn: Journal of Viral Hepatitis , Jg. 21 2014, Nr. 7, S. 480 – 490
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MicroRNA-155 controls Toll-like receptor 3- and hepatitis C virus-induced immune responses in the liverIn: Journal of Viral Hepatitis , Jg. 21 2014, Nr. 2, S. 99 – 110
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Toll-like receptor 3-acivated non-parenchymal liver cells control hepadnaviral replication in HBV-transgenic mice lacking the surface antigen (HBsAg)In: Hepatology , Jg. 60 2014, Nr. Suppl. 1, S. 1022ADOI (Open Access)
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Toll-like receptor-mediated immune responses are attenuated in the presence of high levels of hepatitis B virus surface antigenIn: Journal of Viral Hepatitis , Jg. 21 2014, Nr. 12, S. 860 – 872
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B Cells in Chronically Hepatitis C Virus-Infected Individuals Lack a Virus-Induced Mutation Signature in the TP53, CTNNB1, and BCL6 GenesIn: Journal of Virology , Jg. 87 2013, Nr. 5, S. 2956 – 2962
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Identification of proteins that mediate the pro-viral functions of the interferon stimulated gene 15 in hepatitis C virus replicationIn: Antiviral Research , Jg. 100 2013, Nr. 3, S. 654 – 661
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Repetitive actication of toll-like receptor 3 in primary human hepatocytes leads to hyper-responsiveness to poly : in vitroIn: Journal of Hepatology , Jg. 58 2013, Nr. Suppl. 1, S. S144 – S145
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The pro-inflammatory response induced by toll-like receptor activation in vivo is not impaired in the liver of HBV-transgenic mice lacking HBsAgIn: Journal of Hepatology , Jg. 58 2013, Nr. Suppl. 1, S. 163
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Toll-like receptor 3 stimulated primary human non-parenchymal liver cells are potent suppressors of Hepatitis C virus replicationIn: Journal of Hepatology , Jg. 58 2013, Nr. Suppl. 1, S. S145
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Viral replication in HBV-transgenic mice lacking the HBsAg significantly induces interferon responsesIn: Journal of Hepatology , Jg. 58 2013, Nr. Suppl. 1, S. 163
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Activation by pathogen- and damage-associated molecular patterns regulates the expression of RANTES in primary hepatic stellate cellsIn: Hepatology , Jg. 56 2012, Nr. Suppl. 1, S. 767A
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Application of LNP01-formulated sirnas in vivo activates hepatic toll-like receptors via MYD88-dependent pathways which can be controlled by chemical ribose modificationsIn: Journal of Hepatology , Jg. 56 2012, Nr. Suppl. 2, S. 315
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ISG15 regulates signalling pathways that are involved in HCV replicationIn: Hepatology , Jg. 56 2012, Nr. Suppl. 1, S. 690A – 691A
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ISG15 suppression in hepatocytes, mediated by LNP01-formulated sirnas, leads to enhanced responsiveness to interferon in vivoIn: Journal of Hepatology , Jg. 56 2012, Nr. Suppl. 2, S. 315
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Preclinical development of TLR ligands as drugs for the treatment of chronic viral infectionsIn: Expert Opinion on Drug Discovery , Jg. 7 2012, Nr. 7, S. 597 – 611
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Role of Toll-like receptor 2 in the immune response against hepadnaviral infectionIn: Journal of Hepatology , Jg. 57 2012, Nr. 3, S. 522 – 528
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Toll-like receptor 3 activation of human hepatocytes induces an antiviral state against HCV which is mediated by IFN-lambda but not type I or -II interferonsIn: Hepatology , Jg. 56 2012, Nr. Suppl. 1, S. 285A
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Corticosteroids shift the Toll-like receptor response pattern of primary-isolated murine liver cells from an inflammatory to an anti-inflammatory stateIn: International Immunology , Jg. 23 2011, Nr. 9, S. 537 – 544
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Role of Toll-like receptors in liver health and diseaseIn: Clinical Science , Jg. 121 2011, Nr. 10, S. 415 – 426
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1176 Induction of unfavorable isgs in the liver of HCV patients is due to hyper-responsiveness to IFNS and does not correlate with local IL-28 expressionIn: Journal of Hepatology , Jg. 52 2010, Nr. Suppl. 1, S. S454 – S455
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445 The activation of the hepatic immune system by sirnas is differently controlled by chemical modifications and may involve endosomal toll-like receptorsIn: Journal of Hepatology , Jg. 52 2010, Nr. Suppl. 1, S. S180
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627 HBV suppresses TLR signaling and the crosstalk to the adaptive immune system in murine and human cellsIn: Journal of Hepatology , Jg. 52 2010, Nr. Suppl. 1, S. S246
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The interferon stimulated gene 15 functions as a proviral factor for the hepatitis C virus and as a regulator of the IFN responseIn: Gut , Jg. 59 2010, Nr. 8, S. 1111 – 1119
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Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specificIn: Immunology , Jg. 129 2010, Nr. 3, S. 363 – 374
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Evaluation of Hepatitis E Virus Infection during Jak Inhibitor Therapy in Autimmune Inflammatory Rheumatic DiseasesIn: Annals of the Rheumatic Diseases (ARD) , Jg. 81 2022, Nr. Suppl. 1, S. 1832
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Hepatitis B virus entry in primary human hepatocytes initiates toll-like receptor 2-dependent immune signalingIn: Journal of Hepatology , Jg. 68 2018, Nr. Suppl. 1, S. 793
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Hepatitis B virus activates toll-like receptor 2 signaling upon infection of primary human hepatocytesIn: Journal of Hepatology , Jg. 64 2016, Nr. 2, Suppl., S. S394
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Nucleic Acid-Based Polymers Effective against Hepatitis B Virus Infection in Patients Do Not Harbour Immune Stimulatory Properties in Primary Isolated Blood or Liver CellsIn: Journal of Hepatology , Jg. 64 2016, Nr. 2, Suppl., S. S395
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All-in-one liver cell preparation : high quality of functional primary human hepatocytes, liver sinusoidal endothelial cells, Kupffer cells and hepatic stellate cellsIn: Hepatology , Jg. 60 2014, Nr. Suppl. 1, S. 814A
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Hepatitis B virus surface antigen suppresses innate and adaptive immune responses of murine and human liver cellsIn: Journal of Hepatology , Jg. 56 2012, Nr. Supplement 2, S. S174
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Primary human hepatocytes inhibit expansion of virus-specific CD8+ T cells in vitroIn: Journal of Hepatology , Jg. 56 2012, Nr. Supplement 2, S. S318
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TLR-3 dependent immunological properties of liver cells are controlled by anti-inflammatory cytokines through modulation of MIR-155 expressionIn: Journal of Hepatology , Jg. 56 2012, Nr. Supplement 2, S. S302 – S303
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Toll-like receptor-activated human hepatocytes produce inflammatory cytokines and type III interferons, resulting in IFN-γ-mediated suppression of HCV in vitroIn: Journal of Hepatology , Jg. 56 2012, Nr. Suppl. 2, S. S56
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Activation of the Hepatic Immune System by application of Sirnas in Vivo can be controlled by Chemical Ribose Modifications of the Sirna Backbone
The 62nd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2011,In: Hepatology , Jg. 54 2011, Nr. Suppl. 1, S. 520A -
ISG15 and microrna-122 regulate hepatitis C virus replication independently
46th annual meeting of the European Association for the Study of the Liver ; Berlin, 30 March-3 April 2011,In: Journal of Hepatology , Jg. 54 2011, Nr. Suppl. 1, S. S124 -
Modulation of HBV replication by cell cycle and differentiation related micrornasIn: Journal of Hepatology , Jg. 54 2011, Nr. Suppl. 1, S. S448 – S449
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Sirna-Induced Supression of ISG15 in Vivo Leads to enhanced Responsiveness to Ebdogneous interferon in Hepatocytes
The 62nd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2011,In: Hepatology , Jg. 54 2011, Nr. Suppl. 1, S. 545A – 546A -
The non-specific activation of liver cells by therapeutically applicated sirnas is minimized by chemical ribose modificatons of the sirna backbone
46th annual meeting of the European Association for the Study of the Liver ; Berlin, 30 March-3 April 2011,In: Journal of Hepatology , Jg. 54 2011, Nr. Suppl. 1, S. S124 -
The toll-like receptor mediated production of interferons and immunomodulatory cytokines is not impaired in primary liver cells from HCV-positive patientsIn: Journal of Hepatology , Jg. 54 2011, Nr. Suppl. 1, S. S309
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446 HCV/TLR3- dependent innate and adaptive immune functions of non-parenchymal liver cells are controlled by interleukin-10 and transforming growth factor betaIn: Journal of Hepatology , Jg. 52 2010, Nr. Suppl. 1, S. S180
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Advanced Method for Isolation of Mouse Hepatocytes, Liver Sinusoidal Endothelial Cells, and Kupffer CellsIn: Hepatitis B Virus: Methods and Protocols / Guo, Haitao; Cuconati, Andrea (Hrsg.) 2017, S. 249 – 258
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Die Bedeutung hepatischer Interferon-Signaturen in der Immunabwehr des Hepatitis-C-VirusDuisburg ; Essen 2017
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Expression of hepatitis B surface antigen in vivo and in vitro induces endoplasmic reticulum stress, impairs autophagy and promotes proliferation
The International Liver Congress 2022 ; 22-26 June 2022, London, UK,In: Journal of Hepatology , Jg. 77 2022, Nr. Supplement 1: Abstracts of The International Liver CongressTM 2022, S. S643 – S644DOI (Open Access) -
Hepatitis B virus-replicating transgenic mice exhibit a functional but restricted responsiveness to exogenous Tlr3 and Rig-I stimuli
The International Liver Congress 2022 ; 22-26 June 2022, London, UK,In: Journal of Hepatology , Jg. 77 2022, Nr. Supplement 1: Abstracts of The International Liver CongressTM 2022, S. S264 – S265DOI (Open Access) -
Hippo inactivation drives BMI1-associated proliferative hepatocarcinogenesis in chronic hepatitis B virus infection
The International Liver Congress 2022 ; 22-26 June 2022, London, UK,In: Journal of Hepatology , Jg. 77 2022, Nr. Supplement 1: Abstracts of The International Liver CongressTM 2022, S. S642DOI (Open Access) -
Hepatitis B virus surface antigen expression determines hepatic immunity and Kupffer cell functions in HBV-transgenic miceIn: Journal of Hepatology , Jg. 75 2021, Nr. Suppl. 2, S. S706