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PD Dr. rer. nat. Ruth Bröring

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Werner, Melanie; Schefczyk, Stefan; Trippler, Martin; Treckmann, Jürgen-Walter; Baba, Hideo Andreas; Gerken, Guido; Schlaak, Jörg Friedrich; Bröring, Ruth
    Antiviral Toll-like Receptor Signaling in Non-Parenchymal Liver Cells Is Restricted to TLR3
    In: Viruses Jg. 14 (2022) Nr. 2,
    ISSN: 1999-4915
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Fahong; Deng, Yingying; Zhang, Shenyan; Zhu, Beidi; Wang, Jun; Wang, Jinyu; Wang, Xueyu; Zhao, Zhenyu; Deng, Wanyu; Mao, Richeng; Shen, Zhongliang; Chen, Jieliang; Bröring, Ruth; Lin, Yong; Lu, Mengji; Zhang, Jiming
    Human hepatocyte-enriched miRNA-192-3p promotes HBV replication through inhibiting Akt/mTOR signalling by targeting ZNF143 in hepatic cell lines
    In: Emerging Microbes & Infections Jg. 11 (2022) Nr. 1, S. 616 - 628
    ISSN: 2222-1751
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Jia; Kemper, Thekla; Bröring, Ruth; Chen, Jieliang; Yuan, Zhenghong; Wang, Xueyu; Lu, Mengji
    Interferon Alpha Induces Cellular Autophagy and Modulates Hepatitis B Virus Replication
    In: Frontiers in Cellular and Infection Microbiology Jg. 12 (2022)
    ISSN: 2235-2988
    Online Volltext: dx.doi.org/ (Open Access)
  • Senff, Tina; Menne, Christopher; Cosmovici, Christine; Lewis-Ximenez, Lia Laura; Aneja, Jasneet; Bröring, Ruth; Kim, Arthur Y.; Westendorf, Astrid; Dittmer, Ulf; Scherbaum, Norbert; Lauer, Georg M.; Timm, Jörg
    Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C
    In: JCI Insight Jg. 7 (2022) Nr. 2,
    ISSN: 2379-3708
    Online Volltext: dx.doi.org/ (Open Access)
  • Bröring, Ruth; Luo, Xufeng; Liu, Jia; Lu, Mengji
    Controversial: Early Innate Responses to Hepatitis B Virus Infection, an Explanation for Viral Persistence?
    In: Virologica Sinica Jg. 36 (2021) Nr. 1, S. 163 - 166
    ISSN: 1995-820X; 1674-0769
    Online Volltext: dx.doi.org/ (Open Access)
  • Xie, Xiaohong; Luo, Jinzhuo; Bröring, Ruth; Zhu, Dan; Zhou, Wenqing; Lu, Mengji; Zheng, Xin; Dittmer, Ulf; Yang, Dongliang; Liu, Jia
    HBeAg induces liver sinusoidal endothelial cell activation to promote intrahepatic CD8 T cell immunity and HBV clearance
    In: Cellular & Molecular Immunology (2021)
    ISSN: 1672-7681; 2042-0226
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhou, Li; He, Rui; Fang, Peining; Li, Mengqi; Yu, Haisheng; Wang, Qiming; Yu, Yi; Wang, Fubing; Zhang, Yi; Chen, Aidong; Peng, Nanfang; Lin, Yong; Zhang, Rui; Trilling, Mirko; Bröring, Ruth; Lu, Mengji; Zhu, Ying; Liu, Shi
    Hepatitis B virus rigs the cellular metabolome to avoid innate immune recognition
    In: Nature Communications Jg. 12 (2021) Nr. 1, S. 98
    ISSN: 2041-1723
    Online Volltext: dx.doi.org/ (Open Access)
  • Luo, Xufeng; Zhang, Rui; Lu, Mengji; Liu, Shi; Baba, Hideo Andrea; Gerken, Guido; Wedemeyer, Heiner; Bröring, Ruth
    Hippo Pathway Counter-Regulates Innate Immunity in Hepatitis B Virus Infection
    In: Frontiers in Immunology Jg. 12 (2021)
    ISSN: 1664-3224
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Du, Yanqin; Bröring, Ruth; Li, Xiaoran; Zhang, Xiaoyong; Liu, Jia; Yang, Dongliang; Lu, Mengji
    In Vivo Mouse Models for Hepatitis B Virus Infection and Their Application
    In: Frontiers in Immunology Jg. 12 (2021)
    ISSN: 1664-3224
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Tegtmeyer, Birthe; Vieyres, Gabrielle; Todt, Daniel; Lauber, Chris; Ginkel, Corinne; Engelmann, Michael; Herrmann, Maike; Pfaller, Christian K.; Vondran, Florian W.R.; Bröring, Ruth; Vafadarnejad, Ehsan; Saliba, Antoine-Emmanuel; Puff, Christina; Baumgärtner, Wolfgang; Miskey, Csaba; Ivics, Zoltán; Steinmann, Eike; Pietschmann, Thomas; Brown, Richard J.P.
    Initial hepatitis c virus infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- And antiviral elements
    In: Journal of Virology Jg. 95 (2021) Nr. 10, S. e00245 - 21
    ISSN: 1098-5514; 0022-538X
    Online Volltext: dx.doi.org/ (Open Access)
  • Du, Yanqin; Anastasiou, Olympia E.; Strunz, Benedikt; Scheuten, Janina; Bremer, Birgit; Kraft, Anke; Kleinsimglinhaus, Karolina; Todt, Daniel; Bröring, Ruth; Hardtke-Wolenski, Matthias; Wu, Jun; Yang, Dongliang; Dittmer, Ulf; Lu, Mengji; Cornberg, Markus; Björkström, Niklas K.; Khera, Tanvi; Wedemeyer, Heiner
    The impact of hepatitis B surface antigen on natural killer cells in patients with chronic hepatitis B virus infection
    In: Liver International Jg. 41 (2021) Nr. 9, S. 2046 - 2058
    ISSN: 1478-3231; 0106-9543; 1600-0676; 1478-3223
    Online Volltext: dx.doi.org/ (Open Access)
  • Schreiter, Thomas; Gieseler, Robert K.; Vílchez-Vargas, Ramiro; Jauregui, Ruy; Sowa, Jan-Peter; Klein-Scory, Susanne; Bröring, Ruth; Croner, Roland S.; Treckmann, Jürgen-Walter; Link, Alexander; Canbay, Ali
    Transcriptome-wide analysis of human liver reveals age-related differences in the expression of select functional gene clusters and evidence for a ppp1r10-governed ‘aging cascade’
    In: Pharmaceutics Jg. 13 (2021) Nr. 12,
    ISSN: 1999-4923
    Online Volltext: dx.doi.org/ (Open Access)
  • Moreira, Adriana R. Schultz; Rüschenbaum, Sabrina; Schefczyk, Stefan; Hendgen-Cotta, Ulrike B.; Rassaf, Tienush; Bröring, Ruth; Hardtke-Wolenski, Matthias; Buitrago-Molina, Laura Elisa
    9-PAHSA prevents mitochondrial dysfunction and increases the viability of steatotic hepatocytes
    In: International Journal of Molecular Sciences (IJMS) Jg. 21 (2020) Nr. 21, S. 8279
    ISSN: 1422-0067; 1661-6596
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Wang, Xueyu; Lin, Yong; Kemper, Thekla; Chen, Jieliang; Yuan, Zhenghong; Liu, Shi; Zhu, Ying; Bröring, Ruth; Lu, Mengji
    AMPK and Akt/mTOR signalling pathways participate in glucose-mediated regulation of hepatitis B virus replication and cellular autophagy
    In: Cellular Microbiology Jg. 22 (2020) Nr. 2, S. e13131
    ISSN: 1462-5814; 1462-5822
    Online Volltext: dx.doi.org/ (Open Access)
  • Dywicki, Janine; Buitrago-Molina, Laura Elisa; Pietrek, Julia; Lieber, Maren; Bröring, Ruth; Khera, Tanvi; Schlue, Jerome; Manns, Michael P.; Wedemeyer, Heiner; Jaeckel, Elmar; Hardtke-Wolenski, Matthias
    Autoimmune hepatitis induction can occur in the liver
    In: Liver International: official journal of the International Association for the Study of the Liver Jg. 40 (2020) Nr. 2, S. 377 - 381
    ISSN: 1478-3231; 1478-3223
    Online Volltext: dx.doi.org/ (Open Access)
  • Kinast, Volker; Plociennikowska, Agnieszka; Anggakusuma; Bracht, Thilo; Todt, Daniel; Brown, Richard J.P.; Boldanova, Tujana; Zhang, Yudi; Brüggemann, Yannick; Friesland, Martina; Engelmann, Michael; Vieyres, Gabrielle; Bröring, Ruth; Vondran, Florian W.R.; Heim, Markus H.; Sitek, Barbara; Bartenschlager, Ralf; Pietschmann, Thomas; Steinmann, Eike
    C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle
    In: Journal of Hepatology Jg. 73 (2020) Nr. 3, S. 549 - 558
    ISSN: 1600-0641; 0168-8278
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhang, Zhenhua; Trippler, Martin; Real, Catherine I.; Werner, Melanie; Luo, Xufeng; Schefczyk, Stefan; Kemper, Thekla; Anastasiou, Olympia E.; Ladiges, Yvonne; Treckmann, Jürgen-Walter; Paul, Andreas; Baba, Hideo Andreas; Allweiss, Lena; Dandri, Maura; Gerken, Guido; Wedemeyer, Heiner; Schlaak, Jörg Friedrich; Lu, Mengji; Bröring, Ruth
    Hepatitis B Virus Particles Activate Toll-Like Receptor 2 Signaling Initially Upon Infection of Primary Human Hepatocytes
    In: Hepatology: official journal of the American Association for the Study of Liver Diseases Jg. 72 (2020) Nr. 3, S. 829 - 844
    ISSN: 1527-3350; 0270-9139
    Online Volltext: dx.doi.org/ (Open Access)
  • Yu, Haisheng; Li, Menqui; He, Rui; Fang, Peining; Wang, Qiming; Yi, Yu; Wang, Fubing; Zhou, Li; Zhang, Yi; Chen, Aidong; Peng, Nanfang; Liu, Dan; Trilling, Mirko; Bröring, Ruth; Wiemer, Erik A.C.; Lu, Mengji; Zhu, Ying; Liu, Shi
    Major Vault Protein Promotes Hepatocellular Carcinoma Through Targeting Interferon Regulatory Factor 2 and Decreasing p53 Activity
    In: Hepatology Jg. 72 (2020) Nr. 2, S. 518 - 534
    ISSN: 1527-3350; 0270-9139
    Online Volltext: dx.doi.org/
  • Wang, Xueyu; Lin, Yong; Liu, Shi; Zhu, Ying; Lu, Kefeng; Bröring, Ruth; Lu, Mengji
    O-GlcNAcylation modulates HBV replication through regulating cellular autophagy at multiple levels
    In: FASEB Journal Jg. 34 (2020) Nr. 11, S. 14473 - 14489
    ISSN: 1530-6860; 0892-6638
    Online Volltext: dx.doi.org/ (Open Access)
  • Bojkova, Denisa; Westhaus, Sandra; Costa, Rui; Timmer, Lejla; Funkenberg, Nora; Korencak, Marek; Streeck, Hendrik; Vondran, Florian; Bröring, Ruth; Heinrichs, Stefan; Lang, Karl S.; Ciesek, Sandra
    Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological Processes
    In: Cells Jg. 9 (2020) Nr. 4,
    ISSN: 2073-4409
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhang, Rui; Lin, Hao-Ming; Bröring, Ruth; Shi, Xiang-de; Yu, Xian-huan; Xu, Lei-bo; Wu, Wen-rui; Liu, Chao
    Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathway
    In: Signal Transduction and Targeted Therapy Jg. 4 (2019) Nr. 1, S. 54
    ISSN: 2059-3635
    Online Volltext: dx.doi.org/ (Open Access)
  • Du, Keye; Liu, Jia; Bröring, Ruth; Zhang, Xiaoyong; Yang, Dongliang; Dittmer, Ulf; Lu, Mengji
    Recent advances in the discovery and development of TLR ligands as novel therapeutics for chronic HBV and HIV infections
    In: Expert Opinion on Drug Discovery Jg. 13 (2018) Nr. 7, S. 661 - 670
    ISSN: 1746-045X; 1746-0441
    Online Volltext: dx.doi.org/
  • Liu, Jia; Yu, Qing; Wu, Weimin; Huang, Xuan; Bröring, Ruth; Werner, Melanie; Roggendorf, Michael; Yang, Dongliang; Lu, Mengji
    TLR2 stimulation strengthens intrahepatic myeloid-derived cell-mediated T cell tolerance through inducing kupffer cell expansion and IL-10 production
    In: Journal of Immunology Jg. 200 (2018) Nr. 7, S. 2341 - 2351
    ISSN: 1550-6606; 0022-1767
    Online Volltext: dx.doi.org/ (Open Access)
  • Liu, Chao; Huang, Xuan; Werner, Melanie; Bröring, Ruth; Ge, Jun; Li, Yongyin; Liao, Baolin; Sun, Jian; Peng, Jie; Lu, Mengji; Hou, Jinlin; Zhang, Xiaoyong
    Elevated expression of chemokine CXCL13 in chronic hepatitis B patients links to immune control during antiviral therapy
    In: Frontiers in Immunology Jg. 8 (2017) S. 323
    ISSN: 1664-3224
    Online Volltext: dx.doi.org/ (Open Access)
  • Liu, C.; Bröring, Ruth; Hideo, B.A.; Real, C.I.; Zhang, R.; Lu, Mengji; Gerken, Guido
    Hepatic expression of oncogenes Bmi1 and Dkk1 can be induced by treatment with hepatitis B virus particles or Lipopolysaccharide in vitro and is up-regulated in liver biopsies of patients with chronic HBV infection
    In: Journal of Hepatology Jg. 66 (2017) Nr. 1, S. S700
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/
  • Zhang, Ruiyong; Real, Catherine I.; Liu, Chao; Baba, Hideo Andreas; Gerken, Guido; Lu, Mengji; Bröring, Ruth
    Hepatic expression of oncogenes Bmi1 and Dkk1 is up-regulated in hepatitis B virus surface antigen–transgenic mice and can be induced by treatment with HBV particles or lipopolysaccharides in vitro
    In: International Journal of Cancer Jg. 141 (2017) Nr. 2, S. 354 - 363
    ISSN: 0020-7136; 1097-0215
    Online Volltext: dx.doi.org/
  • Wan, Yushun; Cao, Wei; Han, Tao; Ren, Sheng; Feng, Jian; Chen, TieLong; Wang, Jun; Bröring, Ruth; Lu, Mengji; Zhu, Ying
    Inducible Rubicon facilitates viral replication by antagonizing interferon production
    In: Cellular & Molecular Immunology Jg. 14 (2017) Nr. 7, S. 607 - 620
    ISSN: 1672-7681; 2042-0226
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Real, Catherine Isabell; Werner, Melanie; Paul, Andreas; Gerken, Guido; Schlaak, Jörg Friedrich; Vaillant, Andrew; Bröring, Ruth
    Nucleic acid-based polymers effective against hepatitis B Virus infection in patients don't harbor immunostimulatory properties in primary isolated liver cells
    In: Scientific Reports Jg. 7 (2017) S. 43838
    ISSN: 2045-2322
    Online Volltext: dx.doi.org/ (Open Access)
  • Bröring, Ruth; Trippler, Martin; Werner, Marc; Real, Catherine Isabell; Megger, Dominik A.; Bracht, Thilo; Schweinsberg, Vincent; Sitek, Barbara; Eisenacher, Martin; Meyer, Helmut Erich; Baba, Hideo Andreas; Weber, Frank; Hoffmann, Andreas-Claudius; Gerken, Guido; Schlaak, Jörg Friedrich
    Hepatic expression of proteasome subunit alpha type-6 is upregulated during viral hepatitis and putatively regulates the expression of ISG15 ubiquitin-like modifier, a proviral host gene in hepatitis C virus infection
    In: Journal of Viral Hepatitis Jg. 23 (2016) Nr. 5, S. 375 - 386
    ISSN: 1352-0504
    Online Volltext: dx.doi.org/
  • Real, Catherine Isabell; Bröring, Ruth; Schlaak, Jörg Friedrich; Gerken, Guido; Schirmbeck, Reinhold; Vornlocher, Hans-Peter; Dittmer, Ulf; Gibbert, Kathrin; John, Matthias Johannes; Ickenstein, Ludger Markus; Jahn-Hofmann, Kerstin; Deckert, Jochen; Hossbach, Markus; Trippler, Martin; Huang, Xuan; Lu, Mengji; Liu, Jia
    Hepatitis B virus genome replication triggers toll-like receptor 3-dependent interferon responses in the absence of hepatitis B surface antigen
    In: Scientific Reports Jg. 6 (2016) S. 24865
    ISSN: 2045-2322
    Online Volltext: dx.doi.org/ (Open Access)
  • Werner, Melanie; Driftmann, Sabrina; Kleinehr, Kathrin; Kaiser, Gernot Maximil; Mathé, Zotlan; Treckmann, Jürgen-Walter; Paul, Andreas; Skibbe, Kathrin; Timm, Jörg; Canbay, Aliekber; Gerken, Guido; Schlaak, Jörg Friedrich; Bröring, Ruth
    All-In-One : Advanced preparation of Human Parenchymal and Non-Parenchymal Liver Cells
    In: PLoS ONE Jg. 10 (2015) Nr. 9, S. e0138655
    ISSN: 1932-6203
    Online Volltext: dx.doi.org/ (Open Access)
  • Werner, M.; Driftmann, S.; Kleinehr, K.; Paul, Andreas; Gerken, Guido; Schlaak, Jörg Friedrich; Bröring, Ruth
    Antiviral activity of human Kupffer cells, liver sinusoidal endothelial cells and hepatic stellate cells against Hepatitis C virus is restricted to toll-like receptor 3 stimulation and involves type I interferons
    In: Journal of Viral Hepatitis Jg. 22 (2015) Nr. S2, S. 71 - 72
    ISSN: 1352-0504; 1365-2893
    Online Volltext: dx.doi.org/
  • Lutterbeck, M.; Driftmann, S.; Kleinehr, K.; Paul, A.; Gerken, Guido; Schlaak, Jörg Friedrich; Bröring, Ruth
    Antiviral activity of human non-parenchymal liver cells is restricted to toll-like receptor 3 and involves type I interferons
    In: Journal of Hepatology Jg. 62 (2015) Nr. Suppl. 2, S. 587
    ISSN: 0168-8278
    Online Volltext: dx.doi.org/
  • Bröring, Ruth; Trippler, M.; Werner, M.; Real, C. I.; Megger, D. A.; Bracht, T.; Schweinsberg, V.; Sitek, B.; Eisenacher, M.; Meyer, H. E.; Baba, Hideo Andreas; Weber, F.; Hoffmann, A. C.; Gerken, Guido; Schlaak, Jörg Friedrich
    Hepatic expression of proteasome subunit alpha type-6 is upregulated during viral hepatitis and putatively regulates the expression of proviral host genes in hepatitis C virus infectio
    In: Journal of Viral Hepatitis Jg. 22 (2015) Nr. S 2, S. 71
    ISSN: 1352-0504; 1365-2893
    Online Volltext: dx.doi.org/
  • Bröring, Ruth; Trippler, M.; Lutterbeck, M.; Real, C. I.; Megger, D. A.; Bracht, T.; Schweinsberg, V.; Sitek, B.; Eisenacher, M.; Meyer, H. E.; Baba, Hideo Andreas; Weber, F.; Hoffmann, A. C.; Gerken, Guido; Schlaak, Jörg Friedrich
    PROTEASOME SUBUNIT ALPHA TYPE-6 REGULATES THE EXPRESSION OF PROVIRAL HOST GENES IN HEPATITIS C VIRUS INFECTION
    In: Journal of Hepatology Jg. 62 (2015) Nr. Suppl. 2, S. 583 - S583
    ISSN: 0168-8278
    Online Volltext: dx.doi.org/
  • Han, Tao; Wan, Yushun; Wang, Jun; Zhao, Peng; Yuan, Yue; Wang, Li; She, Yinglong; Bröring, Ruth; Lu, Mengji; Ye, Linbai; Zhu, Ying
    Set7 facilitates hepatitis C virus replication via enzymatic activity-dependent attenuation of the IFN-related pathway
    In: Journal of Immunology Jg. 194 (2015) Nr. 6, S. 2757 - 2768
    ISSN: 0022-1767; 1048-3233; 1047-7381
    Online Volltext: dx.doi.org/ (Open Access)
  • Real, C. I.; Lu, M.; Hossbach, M.; Deckert, J.; Jahn-Hofmann, K.; Ickenstein, L. M.; John, M. M.; Trippler, M.; Gibbert, K.; Dittmer, Ulf; Vornlocher, H. P.; Schirmbeck, R.; Gerken, Guido; Schlaak, Jörg Friedrich; Bröring, Ruth
    The hepatitis B virus (HBV) surface antigen (HBsAg) prevents hepadnaviral replication-dependent interferon responses, which are mediated by non-parenchymal liver cells in a HBV transgenic mouse model
    In: Journal of Viral Hepatitis Jg. 22 (2015) Nr. S2, S. 29 - 30
    ISSN: 1352-0504; 1365-2893
    Online Volltext: dx.doi.org/
  • Real, C. I.; Lu, M.; Hossbach, M.; Deckert, J.; Jahn-Hofmann, K.; Ickenstein, L. M.; John, M. J.; Trippler, M.; Gibbert, K.; Dittmer, U.; Vornlocher, H. P.; Schirmbeck, R.; Gerken, Guido; Schlaak, Jörg Friedrich; Bröring, Ruth
    The hepatitis B virus (HBV) surface antigen impedes hepadnaviral replication-dependent interferon responses in a HBV transgenic mouse model
    In: Journal of Hepatology Jg. 62 (2015) Nr. Suppl. 2, S. 286
    ISSN: 0168-8278
    Online Volltext: dx.doi.org/
  • Noordeen, Faseeha; Jilbert, Allison R.; Vaillant, Andrew; Schlaak, Jörg Friedrich; Bröring, Ruth; Werner, Melanie; Finnie, John; Reaiche-Miller, Georget; Ajilian, Behzad B.; Qiao, Qiao; Grosse, Arend; Scougall, Catherine A.
    Therapeutic Antiviral Effect of the Nucleic Acid Polymer REP 2055 against Persistent Duck Hepatitis B Virus Infection
    In: PLoS ONE Jg. 10 (2015) Nr. 11, S. e0140909
    ISSN: 1932-6203
    Online Volltext: dx.doi.org/ (Open Access)
  • Bröring, Ruth; Real, Catherine; John, Matthias J.; Jahn-Hofmann, Kerstin; Ickenstein, Ludger M.; Kleinehr, Kathrin; Paul, Andreas; Sutter, Kathrin; Dittmer, Ulf; Gerken, Guido; Schlaak, Jörg Friedrich
    Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro
    In: International Immunology Jg. 26 (2014) Nr. 1, S. 35 - 46
    ISSN: 0953-8178; 1460-2377
    Online Volltext: dx.doi.org/
  • Tucci, Felicia A.; Bröring, Ruth; Lutterbeck, Melanie; Schlaak, Jörg Friedrich; Küppers, Ralf
    Intrahepatic B-cell follicles of chronically hepatitis C virus-infected individuals lack signs of an ectopic germinal center reaction
    In: European Journal of Immunology Jg. 44 (2014) Nr. 6, S. 1842 - 1850
    ISSN: 1521-4141
    Online Volltext: dx.doi.org/
  • Thoens, Christine; Berger, Christoph; Trippler, Martin; Siemann, Holger; Lutterbeck, M.; Bröring, Ruth; Schlaak, Jörg Friedrich; Heinemann, Falko M.; Heinold, Andreas; Nattermann, Jacob; Scherbaum, Norbert; Alter, Galit; Timm, Jörg
    KIR2DL3+NKG2A− natural killer cells are associated with protection from productive hepatitis C virus infection in people who inject drugs
    In: Journal of Hepatology Jg. 61 (2014) Nr. 3, S. 475 - 481
    ISSN: 1600-0641
    Online Volltext: dx.doi.org/
  • Bröring, Ruth; Lutterbeck, M.; Trippler, M.; Kleinehr, K.; Poggenpohl, L.; Paul, Andreas; Gerken, Guido; Schlaak, Jörg Friedrich
    Long-term stimulation of Toll-like receptor 3 in primary human hepatocytes leads to sensitization for antiviral responses induced by poly I : C treatment
    In: Journal of Viral Hepatitis Jg. 21 (2014) Nr. 7, S. 480 - 490
    ISSN: 1365-2893
    Online Volltext: dx.doi.org/
  • Jiang, M.; Bröring, Ruth; Trippler, M.; Wu, J.; Zhang, E.; Zhang, X.; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    MicroRNA-155 controls Toll-like receptor 3- and hepatitis C virus-induced immune responses in the liver
    In: Journal of Viral Hepatitis Jg. 21 (2014) Nr. 2, S. 99 - 110
    ISSN: 1352-0504; 1365-2893
    Online Volltext: dx.doi.org/
  • Real, C. I.; Lu, M. J.; Hossbach, M.; Jahn-Hofmann, K.; Ickenstein, L. M.; John, M. J.; Vornlocher, H. P.; Schirmbeck, R.; Lutterbeck, M.; Gibbert, K.; Dittmer, Ulf; Gerken, Guido; Schlaak, Jörg Friedrich; Bröring, Ruth
    Toll-like receptor 3-acivated non-parenchymal liver cells control hepadnaviral replication in HBV-transgenic mice lacking the surface antigen (HBsAg)
    In: Hepatology Jg. 60 (2014) Nr. Suppl. 1, S. 1022A
    ISSN: 0270-9139; 1527-3350
    Online Volltext: dx.doi.org/ (Open Access)
  • Jiang, M; Bröring, Ruth; Trippler, M; Poggenpohl, L; Fiedler, Melanie; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    Toll-like receptor-mediated immune responses are attenuated in the presence of high levels of hepatitis B virus surface antigen
    In: Journal of Viral Hepatitis Jg. 21 (2014) Nr. 12, S. 860 - 872
    ISSN: 1352-0504; 1365-2893
    Online Volltext: dx.doi.org/
  • Tucci, Felicia Anna; Bröring, Ruth; Johansson, Patricia; Schlaak, Jörg Friedrich; Küppers, Ralf
    B Cells in Chronically Hepatitis C Virus-Infected Individuals Lack a Virus-Induced Mutation Signature in the TP53, CTNNB1, and BCL6 Genes
    In: Journal of Virology Jg. 87 (2013) Nr. 5, S. 2956 - 2962
    ISSN: 1098-5514; 0022-538X
    Online Volltext: dx.doi.org/
  • Real, Catherine I.; Megger, Dominik A.; Sitek, Barbara; Jahn-Hofmann, Kerstin; Ickenstein, Ludger M.; John, Matthias J.; Walker, Andreas; Timm, Jörg; Kuhlmann, Katja; Eisenacher, Martin; Meyer, Helmut E.; Gerken, Guido; Bröring, Ruth; Schlaak, Jörg Friedrich
    Identification of proteins that mediate the pro-viral functions of the interferon stimulated gene 15 in hepatitis C virus replication
    In: Antiviral Research Jg. 100 (2013) Nr. 3, S. 654 - 661
    ISSN: 0166-3542; 1872-9096
    Online Volltext: dx.doi.org/
  • Gerken, Guido; Trippler, M.; Kleinehr, K.; Paul, Andreas; Bröring, Ruth; Schlaak, Jörg Friedrich; Lutterbeck, M.
    Repetitive actication of toll-like receptor 3 in primary human hepatocytes leads to hyper-responsiveness to poly : in vitro
    In: Journal of Hepatology Jg. 58 (2013) Nr. Suppl. 1, S. S144 - S145
    ISSN: 1600-0641
    Online Volltext: dx.doi.org/
  • Real, C. I.; Bröring, Ruth; Kleinehr, K.; Driftmann, S.; Schirmbeck, R.; Lu, M.; Gerken, Guido; Schlaak, Jörg Friedrich
    The pro-inflammatory response induced by toll-like receptor activation in vivo is not impaired in the liver of HBV-transgenic mice lacking HBsAg
    In: Journal of Hepatology Jg. 58 (2013) Nr. Suppl. 1, S. 163
    ISSN: 0168-8278
  • Paul, Andreas; Schlaak, Jörg Friedrich; Kleinehr, K.; Bröring, Ruth; Lutterbeck, M.; Guido, G.
    Toll-like receptor 3 stimulated primary human non-parenchymal liver cells are potent suppressors of Hepatitis C virus replication
    In: Journal of Hepatology Jg. 58 (2013) Nr. Suppl. 1, S. S145
    ISSN: 1600-0641
    Online Volltext: dx.doi.org/
  • Real, C. I.; Bröring, Ruth; Trippler, M.; Jahn-Hofmann, K.; Ickenstein, L.; John, M.; Kleinehr, K.; Driftmann, S.; Kemper, T.; Vornlocher, H. P.; Schirmbeck, R.; Lu, M.; Gerken, Guido; Schlaak, Jörg Friedrich
    Viral replication in HBV-transgenic mice lacking the HBsAg significantly induces interferon responses
    In: Journal of Hepatology Jg. 58 (2013) Nr. Suppl. 1, S. 163
    ISSN: 0168-8278
  • Wang, B.; Real, C. I.; Lutterbeck, M.; Bröring, Ruth; Gerken, Guido; Lu, M. J.; Schlaak, Jörg Friedrich
    Activation by pathogen- and damage-associated molecular patterns regulates the expression of RANTES in primary hepatic stellate cells
    In: Hepatology Jg. 56 (2012) Nr. Suppl. 1, S. 767A
    ISSN: 0270-9139; 1527-3350
  • Real, C. I.; Bröring, Ruth; Jahn-Hofmann, K.; Ickenstein, L.; John, M.; Kleinehr, K.; Gerken, Guido; Schlaak, Jörg Friedrich
    Application of LNP01-formulated sirnas in vivo activates hepatic toll-like receptors via MYD88-dependent pathways which can be controlled by chemical ribose modifications
    In: Journal of Hepatology Jg. 56 (2012) Nr. Suppl. 2, S. 315
    ISSN: 0168-8278
  • Real, C. I.; Bröring, Ruth; Megger, D.; Pankraz, O.; Sitek, B.; Kleinehr, K.; Gerken, Guido; Schlaak, Jörg Friedrich
    ISG15 regulates signalling pathways that are involved in HCV replication
    In: Hepatology Jg. 56 (2012) Nr. Suppl. 1, S. 690A - 691A
    ISSN: 0270-9139; 1527-3350
  • Real, C. I.; Bröring, Ruth; Jahn-Hofmann, K.; Ickenstein, L.; John, M.; Kleinehr, K.; Gerken, Guido; Schlaak, Jörg Friedrich
    ISG15 suppression in hepatocytes, mediated by LNP01-formulated sirnas, leads to enhanced responsiveness to interferon in vivo
    In: Journal of Hepatology Jg. 56 (2012) Nr. Suppl. 2, S. 315
    ISSN: 0168-8278
  • Zhang, Xiaoyong; Kraft, Anke; Bröring, Ruth; Schlaak, Jörg Friedrich; Dittmer, Ulf; Lu, Mengji
    Preclinical development of TLR ligands as drugs for the treatment of chronic viral infections
    In: Expert Opinion on Drug Discovery Jg. 7 (2012) Nr. 7, S. 597 - 611
    ISSN: 1746-045X; 1746-0441
    Online Volltext: dx.doi.org/
  • Zhang, Xiaoyong; Ma, Zhiyong; Liu, Hongyan; Liu, Jia; Meng, Zhongji; Bröring, Ruth; Yang, Dongliang; Schlaak, Jörg Friedrich; Roggendorf, Michael; Lu, Mengji
    Role of Toll-like receptor 2 in the immune response against hepadnaviral infection
    In: Journal of Hepatology Jg. 57 (2012) Nr. 3, S. 522 - 528
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/
  • Bröring, Ruth; Lutterbeck, M.; Kleinehr, K.; Paul, Andreas; Gerken, Guido; Schlaak, Jörg Friedrich
    Toll-like receptor 3 activation of human hepatocytes induces an antiviral state against HCV which is mediated by IFN-lambda but not type I or -II interferons
    In: Hepatology Jg. 56 (2012) Nr. Suppl. 1, S. 285A
    ISSN: 0270-9139; 1527-3350
  • Bröring, Ruth; Montag, Mario; Jiang, Min; Lu, Mengji; Sowa, Jan-Peter; Kleinehr, Kathrin; Gerken, Guido; Schlaak, Jörg Friedrich
    Corticosteroids shift the Toll-like receptor response pattern of primary-isolated murine liver cells from an inflammatory to an anti-inflammatory state
    In: International Immunology Jg. 23 (2011) Nr. 9, S. 537 - 544
    ISSN: 0953-8178; 1460-2377
    Online Volltext: dx.doi.org/
  • Bröring, Ruth; Lu, Mengji; Schlaak, Jörg Friedrich; Schlaak, Joerg F.
    Role of Toll-like receptors in liver health and disease
    In: Clinical Science Jg. 121 (2011) Nr. 10, S. 415 - 426
    ISSN: 1470-8736; 0143-5221; 0301-0538; 0143-5221; 0009-9287
    Online Volltext: dx.doi.org/
  • Trippler, M.; Bröring, Ruth; Poggenpohl, L.; Gerken, Guido; Schlaak, Jörg Friedrich
    1176 Induction of unfavorable isgs in the liver of HCV patients is due to hyper-responsiveness to IFNS and does not correlate with local IL-28 expression
    In: Journal of Hepatology Jg. 52 (2010) Nr. Suppl. 1, S. S454 - S455
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/
  • Bröring, Ruth; John, M.; Kleinehr, K.; Sowa, Jan-Peter; Bucchi, A.; Gerken, Guido; Schlaak, Jörg Friedrich
    445 The activation of the hepatic immune system by sirnas is differently controlled by chemical modifications and may involve endosomal toll-like receptors
    In: Journal of Hepatology Jg. 52 (2010) Nr. Suppl. 1, S. S180
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/
  • Jiang, M.; Trippler, M.; Bröring, Ruth; Poggenpohl, L.; Wu, J.; Roggendorf, Michael; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    627 HBV suppresses TLR signaling and the crosstalk to the adaptive immune system in murine and human cells
    In: Journal of Hepatology Jg. 52 (2010) Nr. Suppl. 1, S. S246
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/
  • Bröring, Ruth; Zhang, Xiaozhen; Kottilil, Shyam; Trippler, Martin; Jiang, Min; Lu, Mengji; Gerken, Guido; Schlaak, Jörg Friedrich
    The interferon stimulated gene 15 functions as a proviral factor for the hepatitis C virus and as a regulator of the IFN response
    In: Gut Jg. 59 (2010) Nr. 8, S. 1111 - 1119
    ISSN: 1468-3288; 0017-5749
    Online Volltext: dx.doi.org/
  • Wu, Jun; Meng, Zhongji; Jiang, Min; Zhang, Ejuan; Trippler, Martin; Bröring, Ruth; Bucchi, Agnes; Krux, Frank; Dittmer, Ulf; Yang, Dongliang; Roggendorf, Michael; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific
    In: Immunology Jg. 129 (2010) Nr. 3, S. 363 - 374
    ISSN: 1365-2567; 0019-2805
    Online Volltext: dx.doi.org/

    • Abstracts

  • Schefczyk, Stefan; Merz, Simon; Luo, Xufeng; Trippler, Martin; Hardtke-Wolenski, Matthias; Bröring, Ruth
    Hepatitis B virus surface antigen expression determines hepatic immunity and Kupffer cell functions in HBV-transgenic mice
    In: Journal of Hepatology Jg. 75 (2021) Nr. Suppl. 2, S. 294 - S803
    ISSN: 1600-0641; 0168-8278
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhenhua, Zhu; Trippler, Martin; Real, Catherine Isabell; Werner, Melanie; Kemper, Thekla; Baba, Hideo Andreas; Treckmann, Jürgen-Walter; Paul, A.; Gerken, Guido; Schlaak, Jörg Friedrich; Lu, Mengji; Bröring, Ruth
    Hepatitis B virus entry in primary human hepatocytes initiates toll-like receptor 2-dependent immune signaling
    In: Journal of Hepatology Jg. 68 (2018) Nr. Suppl. 1, S. 793
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/
  • Bröring, Ruth; Zhang, Z.; Trippler, M.; Real, C.; Werner, M.; Gerken, Guido; Schlaak, Jörg Friedrich; Lu, Mengji
    Hepatitis B virus activates toll-like receptor 2 signaling upon infection of primary human hepatocytes
    In: Journal of Hepatology / International Liver Congress ; EASL ; Barcelona, April 13-17, 2016 Jg. 64 (2016) Nr. 2, Suppl., S. S394
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/
  • Real, C.; Werner, M.; Paul, Andreas; Gerken, Guido; Schlaak, Jörg Friedrich; Vaillant, A.; Bröring, Ruth
    Nucleic Acid-Based Polymers Effective against Hepatitis B Virus Infection in Patients Do Not Harbour Immune Stimulatory Properties in Primary Isolated Blood or Liver Cells
    In: Journal of Hepatology / International Liver Congress ; EASL ; Barcelona, April 13-17, 2016 Jg. 64 (2016) Nr. 2, Suppl., S. S395
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/
  • Lutterbeck, M.; Real, C. I.; Skibbe, K.; Timm, Jörg; Paul, Andreas; Gerken, Guido; Schlaak, Jörg Friedrich; Bröring, Ruth
    All-in-one liver cell preparation : high quality of functional primary human hepatocytes, liver sinusoidal endothelial cells, Kupffer cells and hepatic stellate cells
    In: Hepatology Jg. 60 (2014) Nr. Suppl. 1, S. 814A
    ISSN: 0270-9139; 1527-3350
    Online Volltext: dx.doi.org/
  • Jiang, M.; Trippler, M.; Bröring, Ruth; Poggenpohl, L.; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    Hepatitis B virus surface antigen suppresses innate and adaptive immune responses of murine and human liver cells
    In: Journal of Hepatology / International Liver Congress™ ; Annual meeting of the European Association for the Study of the Liver ; 18-22 April 2012, Barcelona Jg. 56 (2012) Nr. Supplement 2, S. S174
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/
  • Ziegler, S.; Bröring, Ruth; Nahmias, Yaakov; Schlaak, Jörg Friedrich; Timm, Jörg
    Primary human hepatocytes inhibit expansion of virus-specific CD8+ T cells in vitro
    In: Journal of Hepatology / International Liver Congress™ ; Annual meeting of the European Association for the Study of the Liver ; 18-22 April 2012, Barcelona Jg. 56 (2012) Nr. Supplement 2, S. S318
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/
  • Jiang, M.; Trippler, M.; Bröring, Ruth; Wu, J.; Zhang, E.; Zhang, X.; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    TLR-3 dependent immunological properties of liver cells are controlled by anti-inflammatory cytokines through modulation of MIR-155 expression
    In: Journal of Hepatology / International Liver Congress™ ; Annual meeting of the European Association for the Study of the Liver ; 18-22 April 2012, Barcelona Jg. 56 (2012) Nr. Supplement 2, S. S302 - S303
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/
  • Bröring, Ruth; Lutterbeck, M.; Kleinehr, K.; Paul, Andreas; Gerken, Guido; Schlaak, Jörg Friedrich
    Toll-like receptor-activated human hepatocytes produce inflammatory cytokines and type III interferons, resulting in IFN-γ-mediated suppression of HCV in vitro
    In: Journal of Hepatology / International Liver Congress™ 2012 ; 47th annual meeting of the European Association for the Study of the Liver ; 18-22 April 2012, Barcelona Jg. 56 (2012) Nr. Suppl. 2, S. S56
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/
  • Real, Catherine; Bröring, Ruth; Ickenstein, Ludger M.; Jahn-Hofmann, Kerstin; John, Matthias J.; Kleinehr, Kathrin; Gerken, Guido; Schlaak, Jörg Friedrich;
    Activation of the Hepatic Immune System by application of Sirnas in Vivo can be controlled by Chemical Ribose Modifications of the Sirna Backbone
    The 62nd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2011,
    In: Hepatology Jg. 54 (2011) Nr. Suppl. 1, S. 520A
    ISSN: 0270-9139; 1527-3350
    Online Volltext: dx.doi.org/
  • Pankraz, Olessja; Bröring, Ruth; Trippler, M.; Gerken, Guido; Schlaak, Jörg Friedrich;
    ISG15 and microrna-122 regulate hepatitis C virus replication independently
    46th annual meeting of the European Association for the Study of the Liver ; Berlin, 30 March-3 April 2011,
    In: Journal of Hepatology Jg. 54 (2011) Nr. Suppl. 1, S. S124
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/
  • Zhang, X.; Ma, Z.; Wu, C.; Zhang, E.; Bröring, Ruth; Schlaak, Jörg Friedrich; Roggendorf, Michael; Lu, Mengji
    Modulation of HBV replication by cell cycle and differentiation related micrornas
    In: Journal of Hepatology / The International Liver Congress™ 2011 ; 46th annual meeting of the European Association for the Study of the Liver ; Berlin, 30 March-3 April 2011 Jg. 54 (2011) Nr. Suppl. 1, S. S448 - S449
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/
  • Real, Catherine; Bröring, Ruth; Ickenstein, Ludger M.; Jahn-Hofmann, Kerstin; John, Matthias J.; Kleinehr, Kathrin; Gerken, Guido; Schlaak, Jörg Friedrich;
    Sirna-Induced Supression of ISG15 in Vivo Leads to enhanced Responsiveness to Ebdogneous interferon in Hepatocytes
    The 62nd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2011,
    In: Hepatology Jg. 54 (2011) Nr. Suppl. 1, S. 545A - 546A
    ISSN: 0270-9139; 1527-3350
    Online Volltext: dx.doi.org/
  • Real, Catherine I.; Bröring, Ruth; Jahn-Hofmann, K.; Ickenstein, L.; John, M.; Kleinehr, K.; Schlaak, Jörg Friedrich; Gerken, Guido;
    The non-specific activation of liver cells by therapeutically applicated sirnas is minimized by chemical ribose modificatons of the sirna backbone
    46th annual meeting of the European Association for the Study of the Liver ; Berlin, 30 March-3 April 2011,
    In: Journal of Hepatology Jg. 54 (2011) Nr. Suppl. 1, S. S124
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/
  • Bröring, Ruth; Kleinehr, K.; Paul, Andreas; Gerken, Guido; Schlaak, Jörg Friedrich
    The toll-like receptor mediated production of interferons and immunomodulatory cytokines is not impaired in primary liver cells from HCV-positive patients
    In: Journal of Hepatology / The International Liver Congress™ 2011 ; 46th annual meeting of the European Association for the Study of the Liver ; Berlin, 30 March-3 April 2011 Jg. 54 (2011) Nr. Suppl. 1, S. S309
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/
  • Jiang, M.; Wu, J.; Zhang, E.; Meng, Z.; Trippler, M.; Bröring, Ruth; Roggendorf, Michael; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    446 HCV/TLR3- dependent innate and adaptive immune functions of non-parenchymal liver cells are controlled by interleukin-10 and transforming growth factor beta
    In: Journal of Hepatology Jg. 52 (2010) Nr. Suppl. 1, S. S180
    ISSN: 0168-8278; 1600-0641
    Online Volltext: dx.doi.org/

    • Beiträge in Sammelwerken und Tagungsbänden

  • Liu, Jia; Huang, Xuan; Werner, Melanie; Bröring, Ruth; Yang, Dongliang; Lu, Mengji
    Advanced Method for Isolation of Mouse Hepatocytes, Liver Sinusoidal Endothelial Cells, and Kupffer Cells
    In: Hepatitis B Virus: Methods and Protocols / Guo, Haitao; Cuconati, Andrea (Hrsg.) 2017, S. 249 - 258
    ISBN: 978-1-4939-6700-1
    Online Volltext: dx.doi.org/

    • Bücher/Sammelwerke/Tagungsbände

  • Bröring, Ruth
    Die Bedeutung hepatischer Interferon-Signaturen in der Immunabwehr des Hepatitis-C-Virus
    Duisburg ; Essen (2017) 1 CD-ROM