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PD Dr. rer. nat. Ruth Bröring

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Li, Jia; Kemper, Thekla; Bröring, Ruth; Lin, Yong; Wang, Xueyu; Lu, Mengji
    Amphisome plays a role in HBV production and release through the endosomal and autophagic pathways
    In: Hepatology Communications , Jg. 9 2025, Nr. 4, e0654
    DOI (Open Access)
  • Liang, Yaojie; Luo, Xufeng; Schefczyk, Stefan; Muungani, Lorraine T.; Deng, Hui; Wang, Baoju; Baba, Hideo Andreas; Lu, Mengji; Wedemeyer, Heiner; Schmidt, Hartmut; Bröring, Ruth
    Hepatitis B surface antigen expression impairs endoplasmic reticulum stress-related autophagic flux by decreasing LAMP2
    In: JHEP Reports , Jg. 6 2024, Nr. 4, 101012
    DOI, Online Volltext (Open Access)
  • Schrader, Jil A.; Burkard, Thomas L.; Brüggemann, Yannick; Gömer, André; Meister, Toni L.; Fu, Rebecca M.; Mehnert, Ann-Kathrin; Dao Thi, Viet L.; Behrendt, Patrick; Durantel, David; Bröring, Ruth; Vondran, Florian W R; Todt, Daniel; Kinast, Volker; Steinmann, Eike
    EGF receptor modulates HEV entry in human hepatocytes
    In: Hepatology , Jg. 77 2023, Nr. 6, S. 2104 – 2117
    DOI (Open Access)
  • Kinast, Volker; Andreica, Ioana; Ahrenstorf, Gerrit; Gömer, André; Elsner, Carina; Schlienkamp, Sarah; Schrader, Jil Alexandra; Klöhn, Mara; Ulrich, Rainer G.; Bröring, Ruth; Vondran, Florian W.R.; Todt, Daniel; Behrendt, Patrick; Dittmer, Ulf; Hamprecht, Axel; Witte, Torsten; Baraliakos, Xenofon; Steinmann, Eike
    Janus kinase-inhibition modulates hepatitis E virus infection
    In: Antiviral Research , Jg. 217 2023, 105690
    DOI (Open Access)
  • Luo, Xufeng; Zhang, Rui; Schefczyk, Stefan; Liang, Yaojie; Lin, Shu S.; Liu, Shi; Baba, Hideo Andreas; Lange, Christian M.; Wedemeyer, Heiner; Lu, Mengji; Bröring, Ruth
    Nuclear translocation of YAP drives BMI1-associated hepatocarcinogenesis in hepatitis B virus infection
    In: Liver International , Jg. 43 2023, Nr. 9, S. 2002 – 2016
    DOI (Open Access)
  • Schefczyk, Stefan; Luo, Xufeng; Liang, Yaojie; Trippler, Martin; Lu, Mengji; Wedemeyer, Heiner; Schmidt, Hartmut; Bröring, Ruth
    Poly(I:C) Induces Distinct Liver Cell Type-Specific Responses in Hepatitis B Virus-Transgenic Mice In Vitro, but Fails to Induce These Signals In Vivo
    In: Viruses , Jg. 15 2023, Nr. 5, 1203
    DOI (Open Access)
  • Zhang, Ruiyong; Lin, Hao-Ming; Bröring, Ruth; Shi, Xiang-de; Yu, Xian-Huan; Xu, Lei-Bo; Wu, Wen-Rui; Liu, Chao
    Retraction Note: Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathway
    In: Signal Transduction and Targeted Therapy , Jg. 8 2023, Nr. 1, 181
    DOI (Open Access)
  • Schefczyk, Stefan; Luo, Xufeng; Liang, Yaojie; Hasenberg, Mike; Walkenfort, Bernd; Trippler, Martin; Schuhenn, Jonas; Sutter, Kathrin; Lu, Mengji; Wedemeyer, Heiner; Schmidt, Hartmut H.; Broering, Ruth
    Tg1.4HBV-s-rec mice, a crossbred hepatitis B virus-transgenic model, develop mild hepatitis
    In: Scientific Reports , Jg. 13 2023, Nr. 1, 22829
    DOI, Online Volltext (Open Access)
  • Meister, Toni Luise; Brüggemann, Yannick; Nocke, Maximilian K.; Ulrich, Rainer G.; Schuhenn, Jonas; Sutter, Kathrin; Gömer, André; Bader, Verian; Winklhofer, Konstanze F.; Bröring, Ruth; Verhoye, Lieven; Meuleman, Philip; Vondran, Florian W. R.; Camuzet, Charline; Cocquerel, Laurence; Todt, Daniel; Steinmann, Eike
    A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Jg. 119 2022, Nr. 34, e2202653119
    DOI (Open Access)
  • Werner, Melanie; Schefczyk, Stefan; Trippler, Martin; Treckmann, Jürgen-Walter; Baba, Hideo Andreas; Gerken, Guido; Schlaak, Jörg Friedrich; Bröring, Ruth
    Antiviral Toll-like Receptor Signaling in Non-Parenchymal Liver Cells Is Restricted to TLR3
    In: Viruses , Jg. 14 2022, Nr. 2, 218
    DOI (Open Access)
  • Li, Fahong; Deng, Yingying; Zhang, Shenyan; Zhu, Beidi; Wang, Jun; Wang, Jinyu; Wang, Xueyu; Zhao, Zhenyu; Deng, Wanyu; Mao, Richeng; Shen, Zhongliang; Chen, Jieliang; Bröring, Ruth; Lin, Yong; Lu, Mengji; Zhang, Jiming
    Human hepatocyte-enriched miRNA-192-3p promotes HBV replication through inhibiting Akt/mTOR signalling by targeting ZNF143 in hepatic cell lines
    In: Emerging Microbes & Infections , Jg. 11 2022, Nr. 1, S. 616 – 628
    DOI (Open Access)
  • Li, Jia; Kemper, Thekla; Bröring, Ruth; Chen, Jieliang; Yuan, Zhenghong; Wang, Xueyu; Lu, Mengji
    Interferon Alpha Induces Cellular Autophagy and Modulates Hepatitis B Virus Replication
    In: Frontiers in Cellular and Infection Microbiology , Jg. 12 2022, 804011
    DOI, Online Volltext (Open Access)
  • Senff, Tina; Menne, Christopher; Cosmovici, Christine; Lewis-Ximenez, Lia Laura; Aneja, Jasneet; Bröring, Ruth; Kim, Arthur Y.; Westendorf, Astrid; Dittmer, Ulf; Scherbaum, Norbert; Lauer, Georg M.; Timm, Jörg
    Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C
    In: JCI Insight , Jg. 7 2022, Nr. 2, e155432
    DOI (Open Access)
  • Bröring, Ruth; Luo, Xufeng; Liu, Jia; Lu, Mengji
    Controversial: Early Innate Responses to Hepatitis B Virus Infection, an Explanation for Viral Persistence?
    In: Virologica Sinica , Jg. 36 2021, Nr. 1, S. 163 – 166
    DOI (Open Access)
  • Xie, Xiaohong; Luo, Jinzhuo; Bröring, Ruth; Zhu, Dan; Zhou, Wenqing; Lu, Mengji; Zheng, Xin; Dittmer, Ulf; Yang, Dongliang; Liu, Jia
    HBeAg induces liver sinusoidal endothelial cell activation to promote intrahepatic CD8 T cell immunity and HBV clearance
    In: Cellular & Molecular Immunology , Jg. 18 2021, Nr. 11, S. 2572 – 2574
    DOI (Open Access)
  • Zhou, Li; He, Rui; Fang, Peining; Li, Mengqi; Yu, Haisheng; Wang, Qiming; Yu, Yi; Wang, Fubing; Zhang, Yi; Chen, Aidong; Peng, Nanfang; Lin, Yong; Zhang, Rui; Trilling, Mirko; Bröring, Ruth; Lu, Mengji; Zhu, Ying; Liu, Shi
    Hepatitis B virus rigs the cellular metabolome to avoid innate immune recognition
    In: Nature Communications , Jg. 12 2021, Nr. 1, S. 98
    DOI (Open Access)
  • Luo, Xufeng; Zhang, Rui; Lu, Mengji; Liu, Shi; Baba, Hideo Andrea; Gerken, Guido; Wedemeyer, Heiner; Bröring, Ruth
    Hippo Pathway Counter-Regulates Innate Immunity in Hepatitis B Virus Infection
    In: Frontiers in Immunology , Jg. 12 2021, 684424
    DOI, Online Volltext (Open Access)
  • Du, Yanqin; Bröring, Ruth; Li, Xiaoran; Zhang, Xiaoyong; Liu, Jia; Yang, Dongliang; Lu, Mengji
    In Vivo Mouse Models for Hepatitis B Virus Infection and Their Application
    In: Frontiers in Immunology , Jg. 12 2021, 766534
    DOI, Online Volltext (Open Access)
  • Tegtmeyer, Birthe; Vieyres, Gabrielle; Todt, Daniel; Lauber, Chris; Ginkel, Corinne; Engelmann, Michael; Herrmann, Maike; Pfaller, Christian K.; Vondran, Florian W.R.; Bröring, Ruth; Vafadarnejad, Ehsan; Saliba, Antoine-Emmanuel; Puff, Christina; Baumgärtner, Wolfgang; Miskey, Csaba; Ivics, Zoltán; Steinmann, Eike; Pietschmann, Thomas; Brown, Richard J.P.
    Initial hepatitis c virus infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- And antiviral elements
    In: Journal of Virology , Jg. 95 2021, Nr. 10, S. e00245 – 21
    DOI (Open Access)
  • Du, Yanqin; Anastasiou, Olympia E.; Strunz, Benedikt; Scheuten, Janina; Bremer, Birgit; Kraft, Anke; Kleinsimglinhaus, Karolina; Todt, Daniel; Bröring, Ruth; Hardtke-Wolenski, Matthias; Wu, Jun; Yang, Dongliang; Dittmer, Ulf; Lu, Mengji; Cornberg, Markus; Björkström, Niklas K.; Khera, Tanvi; Wedemeyer, Heiner
    The impact of hepatitis B surface antigen on natural killer cells in patients with chronic hepatitis B virus infection
    In: Liver International , Jg. 41 2021, Nr. 9, S. 2046 – 2058
    DOI (Open Access)
  • Schreiter, Thomas; Gieseler, Robert K.; Vílchez-Vargas, Ramiro; Jauregui, Ruy; Sowa, Jan-Peter; Klein-Scory, Susanne; Bröring, Ruth; Croner, Roland S.; Treckmann, Jürgen-Walter; Link, Alexander; Canbay, Ali
    Transcriptome-wide analysis of human liver reveals age-related differences in the expression of select functional gene clusters and evidence for a ppp1r10-governed ‘aging cascade’
    In: Pharmaceutics , Jg. 13 2021, Nr. 12, 2009
    DOI (Open Access)
  • Moreira, Adriana R. Schultz; Rüschenbaum, Sabrina; Schefczyk, Stefan; Hendgen-Cotta, Ulrike B.; Rassaf, Tienush; Bröring, Ruth; Hardtke-Wolenski, Matthias; Buitrago-Molina, Laura Elisa
    9-PAHSA prevents mitochondrial dysfunction and increases the viability of steatotic hepatocytes
    In: International Journal of Molecular Sciences (IJMS) , Jg. 21 2020, Nr. 21, S. 8279
    DOI, Online Volltext (Open Access)
  • Wang, Xueyu; Lin, Yong; Kemper, Thekla; Chen, Jieliang; Yuan, Zhenghong; Liu, Shi; Zhu, Ying; Bröring, Ruth; Lu, Mengji
    AMPK and Akt/mTOR signalling pathways participate in glucose-mediated regulation of hepatitis B virus replication and cellular autophagy
    In: Cellular Microbiology , Jg. 22 2020, Nr. 2, S. e13131
    DOI (Open Access)
  • Dywicki, Janine; Buitrago-Molina, Laura Elisa; Pietrek, Julia; Lieber, Maren; Bröring, Ruth; Khera, Tanvi; Schlue, Jerome; Manns, Michael P.; Wedemeyer, Heiner; Jaeckel, Elmar; Hardtke-Wolenski, Matthias
    Autoimmune hepatitis induction can occur in the liver
    In: Liver International , Jg. 40 2020, Nr. 2, S. 377 – 381
    DOI (Open Access)
  • Kinast, Volker; Plociennikowska, Agnieszka; Anggakusuma; Bracht, Thilo; Todt, Daniel; Brown, Richard J.P.; Boldanova, Tujana; Zhang, Yudi; Brüggemann, Yannick; Friesland, Martina; Engelmann, Michael; Vieyres, Gabrielle; Bröring, Ruth; Vondran, Florian W.R.; Heim, Markus H.; Sitek, Barbara; Bartenschlager, Ralf; Pietschmann, Thomas; Steinmann, Eike
    C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle
    In: Journal of Hepatology , Jg. 73 2020, Nr. 3, S. 549 – 558
    DOI (Open Access)
  • Zhang, Zhenhua; Trippler, Martin; Real, Catherine I.; Werner, Melanie; Luo, Xufeng; Schefczyk, Stefan; Kemper, Thekla; Anastasiou, Olympia E.; Ladiges, Yvonne; Treckmann, Jürgen-Walter; Paul, Andreas; Baba, Hideo Andreas; Allweiss, Lena; Dandri, Maura; Gerken, Guido; Wedemeyer, Heiner; Schlaak, Jörg Friedrich; Lu, Mengji; Bröring, Ruth
    Hepatitis B Virus Particles Activate Toll-Like Receptor 2 Signaling Initially Upon Infection of Primary Human Hepatocytes
    In: Hepatology , Jg. 72 2020, Nr. 3, S. 829 – 844
    DOI (Open Access)
  • Yu, Haisheng; Li, Menqui; He, Rui; Fang, Peining; Wang, Qiming; Yi, Yu; Wang, Fubing; Zhou, Li; Zhang, Yi; Chen, Aidong; Peng, Nanfang; Liu, Dan; Trilling, Mirko; Bröring, Ruth; Wiemer, Erik A.C.; Lu, Mengji; Zhu, Ying; Liu, Shi
    Major Vault Protein Promotes Hepatocellular Carcinoma Through Targeting Interferon Regulatory Factor 2 and Decreasing p53 Activity
    In: Hepatology , Jg. 72 2020, Nr. 2, S. 518 – 534
    DOI
  • Wang, Xueyu; Lin, Yong; Liu, Shi; Zhu, Ying; Lu, Kefeng; Bröring, Ruth; Lu, Mengji
    O-GlcNAcylation modulates HBV replication through regulating cellular autophagy at multiple levels
    In: The FASEB Journal , Jg. 34 2020, Nr. 11, S. 14473 – 14489
    DOI (Open Access)
  • Bojkova, Denisa; Westhaus, Sandra; Costa, Rui; Timmer, Lejla; Funkenberg, Nora; Korencak, Marek; Streeck, Hendrik; Vondran, Florian; Bröring, Ruth; Heinrichs, Stefan; Lang, Karl S.; Ciesek, Sandra
    Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological Processes
    In: Cells , Jg. 9 2020, Nr. 4, 1003
    DOI (Open Access)
  • Du, Keye; Liu, Jia; Bröring, Ruth; Zhang, Xiaoyong; Yang, Dongliang; Dittmer, Ulf; Lu, Mengji
    Recent advances in the discovery and development of TLR ligands as novel therapeutics for chronic HBV and HIV infections
    In: Expert Opinion on Drug Discovery , Jg. 13 2018, Nr. 7, S. 661 – 670
    DOI
  • Liu, Jia; Yu, Qing; Wu, Weimin; Huang, Xuan; Bröring, Ruth; Werner, Melanie; Roggendorf, Michael; Yang, Dongliang; Lu, Mengji
    TLR2 stimulation strengthens intrahepatic myeloid-derived cell-mediated T cell tolerance through inducing kupffer cell expansion and IL-10 production
    In: The Journal of Immunology (JI) , Jg. 200 2018, Nr. 7, S. 2341 – 2351
    DOI (Open Access)
  • Liu, Chao; Huang, Xuan; Werner, Melanie; Bröring, Ruth; Ge, Jun; Li, Yongyin; Liao, Baolin; Sun, Jian; Peng, Jie; Lu, Mengji; Hou, Jinlin; Zhang, Xiaoyong
    Elevated expression of chemokine CXCL13 in chronic hepatitis B patients links to immune control during antiviral therapy
    In: Frontiers in Immunology , Jg. 8 2017, S. 323
    DOI (Open Access)
  • Liu, C.; Bröring, Ruth; Hideo, B.A.; Real, C.I.; Zhang, R.; Lu, Mengji; Gerken, Guido
    Hepatic expression of oncogenes Bmi1 and Dkk1 can be induced by treatment with hepatitis B virus particles or Lipopolysaccharide in vitro and is up-regulated in liver biopsies of patients with chronic HBV infection
    In: Journal of Hepatology , Jg. 66 2017, Nr. 1, S. S700
    DOI
  • Zhang, Ruiyong; Real, Catherine I.; Liu, Chao; Baba, Hideo Andreas; Gerken, Guido; Lu, Mengji; Bröring, Ruth
    Hepatic expression of oncogenes Bmi1 and Dkk1 is up-regulated in hepatitis B virus surface antigen–transgenic mice and can be induced by treatment with HBV particles or lipopolysaccharides in vitro
    In: International Journal of Cancer , Jg. 141 2017, Nr. 2, S. 354 – 363
    DOI
  • Wan, Yushun; Cao, Wei; Han, Tao; Ren, Sheng; Feng, Jian; Chen, TieLong; Wang, Jun; Bröring, Ruth; Lu, Mengji; Zhu, Ying
    Inducible Rubicon facilitates viral replication by antagonizing interferon production
    In: Cellular & Molecular Immunology , Jg. 14 2017, Nr. 7, S. 607 – 620
    DOI (Open Access)
  • Real, Catherine Isabell; Werner, Melanie; Paul, Andreas; Gerken, Guido; Schlaak, Jörg Friedrich; Vaillant, Andrew; Bröring, Ruth
    Nucleic acid-based polymers effective against hepatitis B Virus infection in patients don't harbor immunostimulatory properties in primary isolated liver cells
    In: Scientific Reports , Jg. 7 2017, S. 43838
    DOI (Open Access)
  • Bröring, Ruth; Trippler, Martin; Werner, Marc; Real, Catherine Isabell; Megger, Dominik A.; Bracht, Thilo; Schweinsberg, Vincent; Sitek, Barbara; Eisenacher, Martin; Meyer, Helmut Erich; Baba, Hideo Andreas; Weber, Frank; Hoffmann, Andreas-Claudius; Gerken, Guido; Schlaak, Jörg Friedrich
    Hepatic expression of proteasome subunit alpha type-6 is upregulated during viral hepatitis and putatively regulates the expression of ISG15 ubiquitin-like modifier, a proviral host gene in hepatitis C virus infection
    In: Journal of Viral Hepatitis , Jg. 23 2016, Nr. 5, S. 375 – 386
    DOI
  • Real, Catherine Isabell; Bröring, Ruth; Schlaak, Jörg Friedrich; Gerken, Guido; Schirmbeck, Reinhold; Vornlocher, Hans-Peter; Dittmer, Ulf; Gibbert, Kathrin; John, Matthias Johannes; Ickenstein, Ludger Markus; Jahn-Hofmann, Kerstin; Deckert, Jochen; Hossbach, Markus; Trippler, Martin; Huang, Xuan; Lu, Mengji; Liu, Jia
    Hepatitis B virus genome replication triggers toll-like receptor 3-dependent interferon responses in the absence of hepatitis B surface antigen
    In: Scientific Reports , Jg. 6 2016, S. 24865
    DOI (Open Access)
  • Werner, Melanie; Driftmann, Sabrina; Kleinehr, Kathrin; Kaiser, Gernot Maximil; Mathe, Zoltan; Treckmann, Jürgen-Walter; Paul, Andreas; Skibbe, Kathrin; Timm, Jörg; Canbay, Aliekber; Gerken, Guido; Schlaak, Jörg Friedrich; Bröring, Ruth
    All-In-One : Advanced preparation of Human Parenchymal and Non-Parenchymal Liver Cells
    In: PLoS ONE , Jg. 10 2015, Nr. 9, S. e0138655
    DOI (Open Access)
  • Werner, M.; Driftmann, S.; Kleinehr, K.; Paul, Andreas; Gerken, Guido; Schlaak, Jörg Friedrich; Bröring, Ruth
    Antiviral activity of human Kupffer cells, liver sinusoidal endothelial cells and hepatic stellate cells against Hepatitis C virus is restricted to toll-like receptor 3 stimulation and involves type I interferons
    In: Journal of Viral Hepatitis , Jg. 22 2015, Nr. S2, S. 71 – 72
    DOI
  • Lutterbeck, M.; Driftmann, S.; Kleinehr, K.; Paul, A.; Gerken, Guido; Schlaak, Jörg Friedrich; Bröring, Ruth
    Antiviral activity of human non-parenchymal liver cells is restricted to toll-like receptor 3 and involves type I interferons
    In: Journal of Hepatology , Jg. 62 2015, Nr. Suppl. 2, S. 587
    DOI
  • Bröring, Ruth; Trippler, M.; Werner, M.; Real, C. I.; Megger, D. A.; Bracht, T.; Schweinsberg, V.; Sitek, B.; Eisenacher, M.; Meyer, H. E.; Baba, Hideo Andreas; Weber, F.; Hoffmann, A. C.; Gerken, Guido; Schlaak, Jörg Friedrich
    Hepatic expression of proteasome subunit alpha type-6 is upregulated during viral hepatitis and putatively regulates the expression of proviral host genes in hepatitis C virus infectio
    In: Journal of Viral Hepatitis , Jg. 22 2015, Nr. S 2, S. 71
    DOI
  • Bröring, Ruth; Trippler, M.; Lutterbeck, M.; Real, C. I.; Megger, D. A.; Bracht, T.; Schweinsberg, V.; Sitek, B.; Eisenacher, M.; Meyer, H. E.; Baba, Hideo Andreas; Weber, F.; Hoffmann, A. C.; Gerken, Guido; Schlaak, Jörg Friedrich
    Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection
    In: Journal of Hepatology , Jg. 62 2015, Nr. Suppl. 2, S. 583 – S583
    DOI
  • Han, Tao; Wan, Yushun; Wang, Jun; Zhao, Peng; Yuan, Yue; Wang, Li; She, Yinglong; Bröring, Ruth; Lu, Mengji; Ye, Linbai; Zhu, Ying
    Set7 facilitates hepatitis C virus replication via enzymatic activity-dependent attenuation of the IFN-related pathway
    In: The Journal of Immunology (JI) , Jg. 194 2015, Nr. 6, S. 2757 – 2768
    DOI (Open Access)
  • Real, C. I.; Lu, M.; Hossbach, M.; Deckert, J.; Jahn-Hofmann, K.; Ickenstein, L. M.; John, M. M.; Trippler, M.; Gibbert, K.; Dittmer, Ulf; Vornlocher, H. P.; Schirmbeck, R.; Gerken, Guido; Schlaak, Jörg Friedrich; Bröring, Ruth
    The hepatitis B virus (HBV) surface antigen (HBsAg) prevents hepadnaviral replication-dependent interferon responses, which are mediated by non-parenchymal liver cells in a HBV transgenic mouse model
    In: Journal of Viral Hepatitis , Jg. 22 2015, Nr. S2, S. 29 – 30
    DOI
  • Real, C. I.; Lu, M.; Hossbach, M.; Deckert, J.; Jahn-Hofmann, K.; Ickenstein, L. M.; John, M. J.; Trippler, M.; Gibbert, K.; Dittmer, U.; Vornlocher, H. P.; Schirmbeck, R.; Gerken, Guido; Schlaak, Jörg Friedrich; Bröring, Ruth
    The hepatitis B virus (HBV) surface antigen impedes hepadnaviral replication-dependent interferon responses in a HBV transgenic mouse model
    In: Journal of Hepatology , Jg. 62 2015, Nr. Suppl. 2, S. 286
    DOI
  • Noordeen, Faseeha; Jilbert, Allison R.; Vaillant, Andrew; Schlaak, Jörg Friedrich; Bröring, Ruth; Werner, Melanie; Finnie, John; Reaiche-Miller, Georget; Ajilian, Behzad B.; Qiao, Qiao; Grosse, Arend; Scougall, Catherine A.
    Therapeutic Antiviral Effect of the Nucleic Acid Polymer REP 2055 against Persistent Duck Hepatitis B Virus Infection
    In: PLoS ONE , Jg. 10 2015, Nr. 11, S. e0140909
    DOI (Open Access)
  • Bröring, Ruth; Real, Catherine; John, Matthias J.; Jahn-Hofmann, Kerstin; Ickenstein, Ludger M.; Kleinehr, Kathrin; Paul, Andreas; Sutter, Kathrin; Dittmer, Ulf; Gerken, Guido; Schlaak, Jörg Friedrich
    Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro
    In: International Immunology , Jg. 26 2014, Nr. 1, S. 35 – 46
    DOI
  • Tucci, Felicia A.; Bröring, Ruth; Lutterbeck, Melanie; Schlaak, Jörg Friedrich; Küppers, Ralf
    Intrahepatic B-cell follicles of chronically hepatitis C virus-infected individuals lack signs of an ectopic germinal center reaction
    In: European Journal of Immunology , Jg. 44 2014, Nr. 6, S. 1842 – 1850
    DOI
  • Thoens, Christine; Berger, Christoph; Trippler, Martin; Siemann, Holger; Lutterbeck, M.; Bröring, Ruth; Schlaak, Jörg Friedrich; Heinemann, Falko M.; Heinold, Andreas; Nattermann, Jacob; Scherbaum, Norbert; Alter, Galit; Timm, Jörg
    KIR2DL3+NKG2A− natural killer cells are associated with protection from productive hepatitis C virus infection in people who inject drugs
    In: Journal of Hepatology , Jg. 61 2014, Nr. 3, S. 475 – 481
    DOI
  • Bröring, Ruth; Lutterbeck, M.; Trippler, M.; Kleinehr, K.; Poggenpohl, L.; Paul, Andreas; Gerken, Guido; Schlaak, Jörg Friedrich
    Long-term stimulation of Toll-like receptor 3 in primary human hepatocytes leads to sensitization for antiviral responses induced by poly I : C treatment
    In: Journal of Viral Hepatitis , Jg. 21 2014, Nr. 7, S. 480 – 490
    DOI
  • Jiang, M.; Bröring, Ruth; Trippler, M.; Wu, J.; Zhang, E.; Zhang, X.; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    MicroRNA-155 controls Toll-like receptor 3- and hepatitis C virus-induced immune responses in the liver
    In: Journal of Viral Hepatitis , Jg. 21 2014, Nr. 2, S. 99 – 110
    DOI
  • Real, C. I.; Lu, M. J.; Hossbach, M.; Jahn-Hofmann, K.; Ickenstein, L. M.; John, M. J.; Vornlocher, H. P.; Schirmbeck, R.; Lutterbeck, M.; Gibbert, K.; Dittmer, Ulf; Gerken, Guido; Schlaak, Jörg Friedrich; Bröring, Ruth
    Toll-like receptor 3-acivated non-parenchymal liver cells control hepadnaviral replication in HBV-transgenic mice lacking the surface antigen (HBsAg)
    In: Hepatology , Jg. 60 2014, Nr. Suppl. 1, S. 1022A
    DOI (Open Access)
  • Jiang, M; Bröring, Ruth; Trippler, M; Poggenpohl, L; Fiedler, Melanie; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    Toll-like receptor-mediated immune responses are attenuated in the presence of high levels of hepatitis B virus surface antigen
    In: Journal of Viral Hepatitis , Jg. 21 2014, Nr. 12, S. 860 – 872
    DOI
  • Tucci, Felicia Anna; Bröring, Ruth; Johansson, Patricia; Schlaak, Jörg Friedrich; Küppers, Ralf
    B Cells in Chronically Hepatitis C Virus-Infected Individuals Lack a Virus-Induced Mutation Signature in the TP53, CTNNB1, and BCL6 Genes
    In: Journal of Virology , Jg. 87 2013, Nr. 5, S. 2956 – 2962
    DOI
  • Real, Catherine I.; Megger, Dominik A.; Sitek, Barbara; Jahn-Hofmann, Kerstin; Ickenstein, Ludger M.; John, Matthias J.; Walker, Andreas; Timm, Jörg; Kuhlmann, Katja; Eisenacher, Martin; Meyer, Helmut E.; Gerken, Guido; Bröring, Ruth; Schlaak, Jörg Friedrich
    Identification of proteins that mediate the pro-viral functions of the interferon stimulated gene 15 in hepatitis C virus replication
    In: Antiviral Research , Jg. 100 2013, Nr. 3, S. 654 – 661
    DOI
  • Gerken, Guido; Trippler, M.; Kleinehr, K.; Paul, Andreas; Bröring, Ruth; Schlaak, Jörg Friedrich; Lutterbeck, M.
    Repetitive actication of toll-like receptor 3 in primary human hepatocytes leads to hyper-responsiveness to poly : in vitro
    In: Journal of Hepatology , Jg. 58 2013, Nr. Suppl. 1, S. S144 – S145
    DOI
  • Real, C. I.; Bröring, Ruth; Kleinehr, K.; Driftmann, S.; Schirmbeck, R.; Lu, M.; Gerken, Guido; Schlaak, Jörg Friedrich
    The pro-inflammatory response induced by toll-like receptor activation in vivo is not impaired in the liver of HBV-transgenic mice lacking HBsAg
    In: Journal of Hepatology , Jg. 58 2013, Nr. Suppl. 1, S. 163
  • Paul, Andreas; Schlaak, Jörg Friedrich; Kleinehr, K.; Bröring, Ruth; Lutterbeck, M.; Guido, G.
    Toll-like receptor 3 stimulated primary human non-parenchymal liver cells are potent suppressors of Hepatitis C virus replication
    In: Journal of Hepatology , Jg. 58 2013, Nr. Suppl. 1, S. S145
    DOI
  • Real, C. I.; Bröring, Ruth; Trippler, M.; Jahn-Hofmann, K.; Ickenstein, L.; John, M.; Kleinehr, K.; Driftmann, S.; Kemper, T.; Vornlocher, H. P.; Schirmbeck, R.; Lu, M.; Gerken, Guido; Schlaak, Jörg Friedrich
    Viral replication in HBV-transgenic mice lacking the HBsAg significantly induces interferon responses
    In: Journal of Hepatology , Jg. 58 2013, Nr. Suppl. 1, S. 163
  • Wang, B.; Real, C. I.; Lutterbeck, M.; Bröring, Ruth; Gerken, Guido; Lu, M. J.; Schlaak, Jörg Friedrich
    Activation by pathogen- and damage-associated molecular patterns regulates the expression of RANTES in primary hepatic stellate cells
    In: Hepatology , Jg. 56 2012, Nr. Suppl. 1, S. 767A
  • Real, C. I.; Bröring, Ruth; Jahn-Hofmann, K.; Ickenstein, L.; John, M.; Kleinehr, K.; Gerken, Guido; Schlaak, Jörg Friedrich
    Application of LNP01-formulated sirnas in vivo activates hepatic toll-like receptors via MYD88-dependent pathways which can be controlled by chemical ribose modifications
    In: Journal of Hepatology , Jg. 56 2012, Nr. Suppl. 2, S. 315
  • Real, C. I.; Bröring, Ruth; Megger, D.; Pankraz, O.; Sitek, B.; Kleinehr, K.; Gerken, Guido; Schlaak, Jörg Friedrich
    ISG15 regulates signalling pathways that are involved in HCV replication
    In: Hepatology , Jg. 56 2012, Nr. Suppl. 1, S. 690A – 691A
  • Real, C. I.; Bröring, Ruth; Jahn-Hofmann, K.; Ickenstein, L.; John, M.; Kleinehr, K.; Gerken, Guido; Schlaak, Jörg Friedrich
    ISG15 suppression in hepatocytes, mediated by LNP01-formulated sirnas, leads to enhanced responsiveness to interferon in vivo
    In: Journal of Hepatology , Jg. 56 2012, Nr. Suppl. 2, S. 315
  • Zhang, Xiaoyong; Kraft, Anke; Bröring, Ruth; Schlaak, Jörg Friedrich; Dittmer, Ulf; Lu, Mengji
    Preclinical development of TLR ligands as drugs for the treatment of chronic viral infections
    In: Expert Opinion on Drug Discovery , Jg. 7 2012, Nr. 7, S. 597 – 611
    DOI
  • Zhang, Xiaoyong; Ma, Zhiyong; Liu, Hongyan; Liu, Jia; Meng, Zhongji; Bröring, Ruth; Yang, Dongliang; Schlaak, Jörg Friedrich; Roggendorf, Michael; Lu, Mengji
    Role of Toll-like receptor 2 in the immune response against hepadnaviral infection
    In: Journal of Hepatology , Jg. 57 2012, Nr. 3, S. 522 – 528
    DOI
  • Bröring, Ruth; Lutterbeck, M.; Kleinehr, K.; Paul, Andreas; Gerken, Guido; Schlaak, Jörg Friedrich
    Toll-like receptor 3 activation of human hepatocytes induces an antiviral state against HCV which is mediated by IFN-lambda but not type I or -II interferons
    In: Hepatology , Jg. 56 2012, Nr. Suppl. 1, S. 285A
  • Bröring, Ruth; Montag, Mario; Jiang, Min; Lu, Mengji; Sowa, Jan-Peter; Kleinehr, Kathrin; Gerken, Guido; Schlaak, Jörg Friedrich
    Corticosteroids shift the Toll-like receptor response pattern of primary-isolated murine liver cells from an inflammatory to an anti-inflammatory state
    In: International Immunology , Jg. 23 2011, Nr. 9, S. 537 – 544
    DOI
  • Bröring, Ruth; Lu, Mengji; Schlaak, Jörg Friedrich; Schlaak, Joerg F.
    Role of Toll-like receptors in liver health and disease
    In: Clinical Science , Jg. 121 2011, Nr. 10, S. 415 – 426
    DOI
  • Trippler, M.; Bröring, Ruth; Poggenpohl, L.; Gerken, Guido; Schlaak, Jörg Friedrich
    1176 Induction of unfavorable isgs in the liver of HCV patients is due to hyper-responsiveness to IFNS and does not correlate with local IL-28 expression
    In: Journal of Hepatology , Jg. 52 2010, Nr. Suppl. 1, S. S454 – S455
    DOI
  • Bröring, Ruth; John, M.; Kleinehr, K.; Sowa, Jan-Peter; Bucchi, A.; Gerken, Guido; Schlaak, Jörg Friedrich
    445 The activation of the hepatic immune system by sirnas is differently controlled by chemical modifications and may involve endosomal toll-like receptors
    In: Journal of Hepatology , Jg. 52 2010, Nr. Suppl. 1, S. S180
    DOI
  • Jiang, M.; Trippler, M.; Bröring, Ruth; Poggenpohl, L.; Wu, J.; Roggendorf, Michael; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    627 HBV suppresses TLR signaling and the crosstalk to the adaptive immune system in murine and human cells
    In: Journal of Hepatology , Jg. 52 2010, Nr. Suppl. 1, S. S246
    DOI
  • Bröring, Ruth; Zhang, Xiaozhen; Kottilil, Shyam; Trippler, Martin; Jiang, Min; Lu, Mengji; Gerken, Guido; Schlaak, Jörg Friedrich
    The interferon stimulated gene 15 functions as a proviral factor for the hepatitis C virus and as a regulator of the IFN response
    In: Gut , Jg. 59 2010, Nr. 8, S. 1111 – 1119
    DOI
  • Wu, Jun; Meng, Zhongji; Jiang, Min; Zhang, Ejuan; Trippler, Martin; Bröring, Ruth; Bucchi, Agnes; Krux, Frank; Dittmer, Ulf; Yang, Dongliang; Roggendorf, Michael; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific
    In: Immunology , Jg. 129 2010, Nr. 3, S. 363 – 374
    DOI

    • Abstracts

  • Andreica, I.; Volker, K.; Elsner, C.; Bröring, Ruth; Vondran, F.; Behrendt, P.; Dittmer, Ulf; Steinmann, E.; Baraliakos, X.
    Evaluation of Hepatitis E Virus Infection during Jak Inhibitor Therapy in Autimmune Inflammatory Rheumatic Diseases
    In: Annals of the Rheumatic Diseases (ARD) , Jg. 81 2022, Nr. Suppl. 1, S. 1832
    DOI
  • Zhenhua, Zhu; Trippler, Martin; Real, Catherine Isabell; Werner, Melanie; Kemper, Thekla; Baba, Hideo Andreas; Treckmann, Jürgen-Walter; Paul, A.; Gerken, Guido; Schlaak, Jörg Friedrich; Lu, Mengji; Bröring, Ruth
    Hepatitis B virus entry in primary human hepatocytes initiates toll-like receptor 2-dependent immune signaling
    In: Journal of Hepatology , Jg. 68 2018, Nr. Suppl. 1, S. 793
    DOI
  • Bröring, Ruth; Zhang, Z.; Trippler, M.; Real, C.; Werner, M.; Gerken, Guido; Schlaak, Jörg Friedrich; Lu, Mengji
    Hepatitis B virus activates toll-like receptor 2 signaling upon infection of primary human hepatocytes
    In: Journal of Hepatology , Jg. 64 2016, Nr. 2, Suppl., S. S394
    DOI
  • Real, C.; Werner, M.; Paul, Andreas; Gerken, Guido; Schlaak, Jörg Friedrich; Vaillant, A.; Bröring, Ruth
    Nucleic Acid-Based Polymers Effective against Hepatitis B Virus Infection in Patients Do Not Harbour Immune Stimulatory Properties in Primary Isolated Blood or Liver Cells
    In: Journal of Hepatology , Jg. 64 2016, Nr. 2, Suppl., S. S395
    DOI
  • Lutterbeck, M.; Real, C. I.; Skibbe, K.; Timm, Jörg; Paul, Andreas; Gerken, Guido; Schlaak, Jörg Friedrich; Bröring, Ruth
    All-in-one liver cell preparation : high quality of functional primary human hepatocytes, liver sinusoidal endothelial cells, Kupffer cells and hepatic stellate cells
    In: Hepatology , Jg. 60 2014, Nr. Suppl. 1, S. 814A
    DOI
  • Jiang, M.; Trippler, M.; Bröring, Ruth; Poggenpohl, L.; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    Hepatitis B virus surface antigen suppresses innate and adaptive immune responses of murine and human liver cells
    In: Journal of Hepatology , Jg. 56 2012, Nr. Supplement 2, S. S174
    DOI
  • Ziegler, S.; Bröring, Ruth; Nahmias, Yaakov; Schlaak, Jörg Friedrich; Timm, Jörg
    Primary human hepatocytes inhibit expansion of virus-specific CD8+ T cells in vitro
    In: Journal of Hepatology , Jg. 56 2012, Nr. Supplement 2, S. S318
    DOI
  • Jiang, M.; Trippler, M.; Bröring, Ruth; Wu, J.; Zhang, E.; Zhang, X.; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    TLR-3 dependent immunological properties of liver cells are controlled by anti-inflammatory cytokines through modulation of MIR-155 expression
    In: Journal of Hepatology , Jg. 56 2012, Nr. Supplement 2, S. S302 – S303
    DOI
  • Bröring, Ruth; Lutterbeck, M.; Kleinehr, K.; Paul, Andreas; Gerken, Guido; Schlaak, Jörg Friedrich
    Toll-like receptor-activated human hepatocytes produce inflammatory cytokines and type III interferons, resulting in IFN-γ-mediated suppression of HCV in vitro
    In: Journal of Hepatology , Jg. 56 2012, Nr. Suppl. 2, S. S56
    DOI
  • Real, Catherine; Bröring, Ruth; Ickenstein, Ludger M.; Jahn-Hofmann, Kerstin; John, Matthias J.; Kleinehr, Kathrin; Gerken, Guido; Schlaak, Jörg Friedrich
    Activation of the Hepatic Immune System by application of Sirnas in Vivo can be controlled by Chemical Ribose Modifications of the Sirna Backbone
    The 62nd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2011,
    In: Hepatology , Jg. 54 2011, Nr. Suppl. 1, S. 520A
    DOI
  • Pankraz, Olessja; Bröring, Ruth; Trippler, M.; Gerken, Guido; Schlaak, Jörg Friedrich
    ISG15 and microrna-122 regulate hepatitis C virus replication independently
    46th annual meeting of the European Association for the Study of the Liver ; Berlin, 30 March-3 April 2011,
    In: Journal of Hepatology , Jg. 54 2011, Nr. Suppl. 1, S. S124
    DOI
  • Zhang, X.; Ma, Z.; Wu, C.; Zhang, E.; Bröring, Ruth; Schlaak, Jörg Friedrich; Roggendorf, Michael; Lu, Mengji
    Modulation of HBV replication by cell cycle and differentiation related micrornas
    In: Journal of Hepatology , Jg. 54 2011, Nr. Suppl. 1, S. S448 – S449
    DOI
  • Real, Catherine; Bröring, Ruth; Ickenstein, Ludger M.; Jahn-Hofmann, Kerstin; John, Matthias J.; Kleinehr, Kathrin; Gerken, Guido; Schlaak, Jörg Friedrich
    Sirna-Induced Supression of ISG15 in Vivo Leads to enhanced Responsiveness to Ebdogneous interferon in Hepatocytes
    The 62nd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2011,
    In: Hepatology , Jg. 54 2011, Nr. Suppl. 1, S. 545A – 546A
    DOI
  • Real, Catherine I.; Bröring, Ruth; Jahn-Hofmann, K.; Ickenstein, L.; John, M.; Kleinehr, K.; Schlaak, Jörg Friedrich; Gerken, Guido
    The non-specific activation of liver cells by therapeutically applicated sirnas is minimized by chemical ribose modificatons of the sirna backbone
    46th annual meeting of the European Association for the Study of the Liver ; Berlin, 30 March-3 April 2011,
    In: Journal of Hepatology , Jg. 54 2011, Nr. Suppl. 1, S. S124
    DOI
  • Bröring, Ruth; Kleinehr, K.; Paul, Andreas; Gerken, Guido; Schlaak, Jörg Friedrich
    The toll-like receptor mediated production of interferons and immunomodulatory cytokines is not impaired in primary liver cells from HCV-positive patients
    In: Journal of Hepatology , Jg. 54 2011, Nr. Suppl. 1, S. S309
    DOI
  • Jiang, M.; Wu, J.; Zhang, E.; Meng, Z.; Trippler, M.; Bröring, Ruth; Roggendorf, Michael; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    446 HCV/TLR3- dependent innate and adaptive immune functions of non-parenchymal liver cells are controlled by interleukin-10 and transforming growth factor beta
    In: Journal of Hepatology , Jg. 52 2010, Nr. Suppl. 1, S. S180
    DOI

    • Beiträge in Sammelwerken und Tagungsbänden

  • Liu, Jia; Huang, Xuan; Werner, Melanie; Bröring, Ruth; Yang, Dongliang; Lu, Mengji
    Advanced Method for Isolation of Mouse Hepatocytes, Liver Sinusoidal Endothelial Cells, and Kupffer Cells
    In: Hepatitis B Virus: Methods and Protocols / Guo, Haitao; Cuconati, Andrea (Hrsg.) 2017, S. 249 – 258
    DOI

    • Bücher/Sammelwerke/Tagungsbände

  • Bröring, Ruth
    Die Bedeutung hepatischer Interferon-Signaturen in der Immunabwehr des Hepatitis-C-Virus
    Duisburg ; Essen 2017

    • Poster / Posterbeiträge

  • Liang, Yaojie; Luo, Xufeng; Schefczyk, Stefan; Baba, Hideo; Lu, Mengji; Bröring, Ruth
    Expression of hepatitis B surface antigen in vivo and in vitro induces endoplasmic reticulum stress, impairs autophagy and promotes proliferation
    The International Liver Congress 2022 ; 22-26 June 2022, London, UK,
    In: Journal of Hepatology , Jg. 77 2022, Nr. Supplement 1: Abstracts of The International Liver CongressTM 2022, S. S643 – S644
    DOI (Open Access)
  • Schefczyk, Stefan; Luo, Xufeng; Liang, Yaojie; Hasenberg, Mike; Walkenfort, Bernd; Trippler, Martin; Lu, Mengji; Wedemeyer, Heiner; Schmidt, Hartmut; Bröring, Ruth
    Hepatitis B virus-replicating transgenic mice exhibit a functional but restricted responsiveness to exogenous Tlr3 and Rig-I stimuli
    The International Liver Congress 2022 ; 22-26 June 2022, London, UK,
    In: Journal of Hepatology , Jg. 77 2022, Nr. Supplement 1: Abstracts of The International Liver CongressTM 2022, S. S264 – S265
    DOI (Open Access)
  • Luo, Xufeng; Zhang, Rui; Liang, Yaojie; Schefczyk, Stefan; Liu, Shi; Baba, Hideo; Lange, Christian; Wedemeyer, Heiner; Lu, Mengji; Bröring, Ruth
    Hippo inactivation drives BMI1-associated proliferative hepatocarcinogenesis in chronic hepatitis B virus infection
    The International Liver Congress 2022 ; 22-26 June 2022, London, UK,
    In: Journal of Hepatology , Jg. 77 2022, Nr. Supplement 1: Abstracts of The International Liver CongressTM 2022, S. S642
    DOI (Open Access)
  • Schefczyk, Stefan; Merz, Simon; Luo, Xufeng; Trippler, Martin; Hardtke-Wolenski, Matthias; Bröring, Ruth
    Hepatitis B virus surface antigen expression determines hepatic immunity and Kupffer cell functions in HBV-transgenic mice
    In: Journal of Hepatology , Jg. 75 2021, Nr. Suppl. 2, S. S706
    DOI