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Honorarprofessor/in, Mikrobiologie I
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Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Interactions with multiple inner kinetochore proteins determine mitotic localization of FACTIn: The Journal of Cell Biology (JCB) , Jg. 224 2025, Nr. 5, e202412042DOI (Open Access)
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Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complexIn: Nature Communications , Jg. 16 2025, Nr. 1, 4823DOI (Open Access)
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A validation strategy to assess the role of phase separation as a determinant of macromolecular localizationIn: Molecular Cell , Jg. 84 2024, Nr. 9, S. 1783 – 1801.e7DOI (Open Access)
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Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptorIn: Current Biology , Jg. 34 2024, Nr. 11, S. 2279 – 2293.e6DOI (Open Access)
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Protocol for validating liquid-liquid phase separation as a driver of membraneless organelle assembly in vitro and human cellsIn: STAR Protocols , Jg. 5 2024, Nr. 4, 103410DOI (Open Access)
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Regulation of minimal spindle midzone organization by mitotic kinasesIn: Nature Communications , Jg. 15 2024, Nr. 1, 9213DOI (Open Access)
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Role of protein kinase PLK1 in the epigenetic maintenance of centromeresIn: Science , Jg. 385 2024, Nr. 6713, S. 1091 – 1097
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Structure of the human KMN complex and implications for regulation of its assemblyIn: Nature Structural & Molecular Biology , Jg. 31 2024, Nr. 6, S. 861 – 873DOI (Open Access)
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Thirty years of structural changesIn: Nature Structural & Molecular Biology , Jg. 31 2024, Nr. 1, S. 4 – 5
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RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore coronaIn: The EMBO Journal , Jg. 42 2023, Nr. 24, e114838DOI (Open Access)
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Stable kinetochore-microtubule attachment requires loop-dependent Ndc80-Ndc80 bindingIn: The EMBO Journal , Jg. 42 2023, Nr. 13, e112504DOI (Open Access)
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The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint ComplexIn: Nature Communications , Jg. 14 2023, Nr. 1, 1529DOI (Open Access)
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Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and DynactinIn: The Journal of Cell Biology (JCB) , Jg. 221 2022, Nr. 11, e202206131DOI (Open Access)
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JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transportIn: The Journal of Cell Biology (JCB) , Jg. 221 2022, Nr. 8, e202110057DOI (Open Access)
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On the role of phase separation in the biogenesis of membraneless compartmentsIn: The EMBO Journal , Jg. 41 2022, Nr. 5, e109952DOI (Open Access)
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Phosphorylation tunes elongation propensity and cohesiveness of INCENP's intrinsically disordered region : Phosphorylation of INCENP disordered regionIn: Journal of Molecular Biology (JMB) , Jg. 434 2022, Nr. 1, 167387
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Reconstitution and use of highly active human CDK1 : Cyclin-B:CKS1 complexesIn: Protein Science , Jg. 31 2022, Nr. 2, S. 528 – 537DOI (Open Access)
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Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochoresIn: The EMBO Journal , Jg. 41 2022, Nr. 9, e110411DOI (Open Access)
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Structure of the human inner kinetochore CCAN complex and its significance for human centromere organizationIn: Molecular Cell , Jg. 82 2022, Nr. 11, S. 2113 – 2131.e8DOI (Open Access)
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Assembly principles and stoichiometry of a complete human kinetochore moduleIn: Science Advances , Jg. 7 2021, Nr. 27, eabg1037DOI (Open Access)
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BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in MitosisIn: Molecular Cell , Jg. 81 2021, Nr. 1, S. 67 – 87.e9DOI (Open Access)
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CDC20 assists its catalytic incorporation in the mitotic checkpoint complexIn: Science , Jg. 371 2021, Nr. 6524, S. 67 – 71
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Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilizationIn: Science Advances , Jg. 7 2021, Nr. 3, S. eabc8590DOI (Open Access)
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Targeted substrate loop insertion by VCP/p97 during PP1 complex disassemblyIn: Nature Structural & Molecular Biology , Jg. 28 2021, Nr. 12, S. 964 – 971
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Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biologyIn: eLife , Jg. 8 2019, S. e48287DOI (Open Access)
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Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensingIn: Nature Communications , Jg. 10 2019, Nr. 1, S. 4046DOI (Open Access)
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Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-couplingIn: eLife , Jg. 8 2019, S. e49539DOI (Open Access)
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Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosisIn: Nature Cell Biology , Jg. 20 2018, S. 800 – 810DOI (Open Access)
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Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80.In: Molecular Cell , Jg. 71 2018, Nr. 6, S. 923 – 939.e10DOI (Open Access)
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Simplified Protocol for Cross-linking Mass Spectrometry Using the MS-Cleavable Cross-linker DSBU with Efficient Cross-link IdentificationIn: Analytical Chemistry , Jg. 90 2018, Nr. 18, S. 10990 – 10999
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The kinetochore proteins CENP-E and CENP-F directly and specifically interact with distinct BUB mitotic checkpoint Ser/Thr kinasesIn: The Journal of Biological Chemistry (JBC) , Jg. 293 2018, Nr. 26, S. 10084 – 10101DOI (Open Access)
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Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme FormationIn: Molecular Cell , Jg. 72 2018, Nr. 4, S. 766 – 777DOI (Open Access)
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A molecular view of kinetochore assembly and functionIn: Biology , Jg. 6 2017, Nr. 1, S. 5DOI (Open Access)
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Basis of catalytic assembly of the mitotic checkpoint complexIn: Nature , Jg. 542 2017, Nr. 7642, S. 498 – 502DOI (Open Access)
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BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint SignalingIn: Current Biology , Jg. 27 2017, Nr. 19, S. 2915 – 2927.e7DOI (Open Access)
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CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loadingIn: eLife , Jg. 6 2017, S. e23352DOI (Open Access)
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Decoding the centromeric nucleosome through CENP-NIn: eLife , Jg. 6 2017, S. e33442DOI (Open Access)
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Structure of the RZZ complex and molecular basis of its interaction with SpindlyIn: The Journal of Cell Biology (JCB) , Jg. 216 2017, Nr. 4, S. 961 – 981DOI (Open Access)
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The greatest kinetochore show on earthIn: EMBO Reports , Jg. 18 2017, Nr. 9, S. 1473 – 1475DOI (Open Access)
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Insights from biochemical reconstitution into the architecture of human kinetochoresIn: Nature , Jg. 537 2016, Nr. 7619, S. 249 – 253
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Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogasterIn: Open Biology , Jg. 6 2016, Nr. 2, 150236DOI (Open Access)
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Microtubules : 50 years on from the discovery of tubulinIn: Nature Reviews Molecular Cell Biology , Jg. 17 2016, Nr. 5, S. 322 – 328DOI (Open Access)
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Molecular basis of outer kinetochore assembly on CENP-TIn: eLife , Jg. 5 2016, S. e21007DOI (Open Access)
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Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and AstrinIn: Nature Communications , Jg. 7 2016, S. 11407DOI (Open Access)
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Progress in the structural and functional characterization of kinetochoresIn: Current Opinion in Structural Biology , Jg. 37 2016, S. 152 – 163DOI (Open Access)
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Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpointIn: Biology Open: BiO , Jg. 5 2016, Nr. 1, S. 11 – 19DOI (Open Access)
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Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human KinetochoresIn: Cell , Jg. 167 2016, Nr. 4, S. 1028 – 1040.e15DOI (Open Access)
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A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpointIn: eLife , Jg. 4 2015, S. e05269DOI (Open Access)
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CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochoresIn: The Journal of Cell Biology (JCB) , Jg. 210 2015, Nr. 1, S. 11 – 22DOI (Open Access)
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Closing the Mad2 cycle : chromosome separation is regulated by a cycle that involves a protein undergoing an unusual topological conversionIn: eLife , Jg. 4 2015, S. e08283DOI (Open Access)
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Complex assembly, crystallization and preliminary x-ray crystallographic analysis of the human Rod-Zwilch-ZW10 (RZZ) complexIn: Acta Crystallographica Section F: Structural Biology and Crystallization Communications , Jg. 71 2015, Nr. 4, S. 438 – 442DOI (Open Access)
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DNA-directed assembly of capture tools for constitutional studies of large protein complexesIn: Small , Jg. 11 2015, Nr. 22, S. 2669 – 2674
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HJURP involvement in De Novo CenH3CENP-A and CENP-C recruitmentIn: Cell Reports , Jg. 11 2015, Nr. 1, S. 22 – 32DOI (Open Access)
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Role of intrinsic and extrinsic factors in the regulation of the mitotic checkpoint kinase Bub1In: PLoS ONE , Jg. 10 2015, Nr. 12, S. 0144673DOI (Open Access)
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The (phospho) needle in the (MELT) haystackIn: Molecular Cell , Jg. 57 2015, Nr. 5, S. 765 – 766DOI (Open Access)
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The Aurora B kinase in chromosome bi-orientation and spindle checkpoint signalingIn: Frontiers in Oncology , Jg. 5 2015, S. 225DOI (Open Access)
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The Molecular Biology of Spindle Assembly Checkpoint Signaling DynamicsIn: Current Biology , Jg. 25 2015, Nr. 20, S. R1002 – R1018DOI (Open Access)
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HORMA domains at the heart of meiotic chromosome dynamicsIn: Developmental Cell , Jg. 31 2014, Nr. 4, S. 389 – 391DOI (Open Access)
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Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1In: The EMBO Journal , Jg. 33 2014, Nr. 22, S. 2704 – 2720DOI (Open Access)
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KI motifs of human Knl1 enhance assembly of comprehensive spindle checkpoint complexes around MELT repeatsIn: Current Biology , Jg. 24 2014, Nr. 1, S. 29 – 39DOI (Open Access)
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Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore OrganizationIn: Molecular Cell , Jg. 53 2014, Nr. 4, S. 591 – 605DOI (Open Access)
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The pseudo GTPase CENP-M drives human kinetochore assemblyIn: eLife , Jg. 3 2014, S. e02978DOI (Open Access)
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Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signalingIn: eLife , Jg. 2 2013, S. e01030DOI (Open Access)
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Esperanto for histones : CENP-A, not CenH3, is the centromeric histone H3 variantIn: Chromosome Research , Jg. 21 2013, Nr. 2, S. 101 – 106
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Loss of survivin influences liver regeneration and is associated with impaired aurora B functionIn: Cell Death and Differentiation , Jg. 20 2013, Nr. 6, S. 834 – 844
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Panta rhei : the APC/C at steady stateIn: The Journal of Cell Biology (JCB) , Jg. 201 2013, Nr. 2, S. 177 – 189
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The spindle-assembly checkpoint and the beauty of self-destruction : ErratumIn: Nature Structural & Molecular Biology , Jg. 20 2013, Nr. 2, S. 244
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A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora BIn: The Journal of Cell Biology (JCB) , Jg. 199 2012, Nr. 2, S. 269 – 284
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Crystal structure of human Aurora B in complex with INCENP and VX-680In: Journal of Medicinal Chemistry , Jg. 55 2012, Nr. 17, S. 7841 – 7848DOI (Open Access)
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Role of the Mad2 dimerization interface in the spindle assembly checkpoint independent of kinetochoresIn: Current Biology , Jg. 22 2012, Nr. 20, S. 1900 – 1908
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Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screenIn: ACS Chemical Biology , Jg. 7 2012, Nr. 1, S. 185 – 196
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Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interactionIn: The Journal of Cell Biology (JCB) , Jg. 196 2012, Nr. 4, S. 451 – 467
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Structural organization of the kinetochore-microtubule interfaceIn: Current Opinion in Cell Biology , Jg. 24 2012, Nr. 1, S. 48 – 56
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The spindle-assembly checkpoint and the beauty of self-destructionIn: Nature Structural & Molecular Biology , Jg. 19 2012, Nr. 11, S. 1059 – 1061
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A general framework for inhibitor resistance in protein kinasesIn: Chemistry and Biology , Jg. 18 2011, Nr. 8, S. 966 – 975
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A general framework for inhibitor resistance in protein kinases : ErratumIn: Chemistry and Biology , Jg. 18 2011, Nr. 10, S. 1341
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Abnormal kinetochore-generated pulling forces from expressing a n-terminally modified Hec1In: PLoS ONE , Jg. 6 2011, Nr. 1, S. e16307DOI (Open Access)
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Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochoreIn: Current Biology , Jg. 21 2011, Nr. 5, S. 391 – 398
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Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correctionIn: The EMBO Journal , Jg. 30 2011, Nr. 8, S. 1508 – 1519
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Investigating a macromolecular complex : the toolkit of methodsIn: Journal of Structural Biology , Jg. 175 2011, Nr. 2, S. 106 – 112
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Spatial exclusivity combined with positive and negative selection of phosphorylation motifs Is the basis for context-dependent mitotic signalingIn: Science Signaling , Jg. 4 2011, Nr. 179 , 1-15, art. no. ra42
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Spindle assembly checkpoint : the third decadeIn: Philosophical Transactions of the Royal Society B: Biological Sciences , Jg. 366 2011, Nr. 1584, S. 3595 – 3604
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Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongationIn: EMBO Reports , Jg. 12 2011, Nr. 4, S. 342 – 349
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The Ndc80 loop region facilitates formation of kinetochore attachment to the dynamic microtubule plus endIn: Current Biology , Jg. 21 2011, Nr. 3, S. 207 – 213
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Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversineIn: The Journal of Cell Biology (JCB) , Jg. 190 2010, Nr. 1, S. 73 – 87
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Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machineryIn: Structure , Jg. 18 2010, Nr. 5, S. 616 – 626
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Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complexIn: The Journal of Cell Biology (JCB) , Jg. 190 2010, Nr. 1, S. 25 – 34
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The MIS12 complex is a protein interaction hub for outer kinetochore assemblyIn: The Journal of Cell Biology (JCB) , Jg. 190 2010, Nr. 5, S. 835 – 852
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Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organizationIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Jg. 106 2009, Nr. 48, S. 20204 – 20209
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Sister chromatid tension and the spindle assembly checkpointIn: Current Opinion in Cell Biology , Jg. 21 2009, Nr. 6, S. 785 – 795
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The Aurora B kinase activity is required for the maintenance of the differentiated state of murine myoblastsIn: Cell death and differentiation , Jg. 16 2009, Nr. 2, S. 321 – 330
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The life and miracles of kinetochoresIn: The EMBO Journal , Jg. 28 2009, Nr. 17, S. 2511 – 2531
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Discovery of selective aminothiazole aurora kinase inhibitorsIn: ACS Chemical Biology , Jg. 3 2008, Nr. 3, S. 180 – 192
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Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complexIn: Cell , Jg. 133 2008, Nr. 3, S. 427 – 439
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MAD contortions : conformational dimerization boosts spindle checkpoint signalingIn: Current opinion in structural biology , Jg. 17 2007, Nr. 6, S. 716 – 725
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PLK1 inhibitors : setting the mitotic death trapIn: Current biology , Jg. 17 2007, Nr. 8, S. R280 – R283
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The Mad2 conformational dimer : structure and implications for the spindle assembly checkpointIn: Cell , Jg. 131 2007, Nr. 4, S. 730 – 743
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The Ndc80 complex : hub of kinetochore activityIn: FEBS Letters , Jg. 581 2007, Nr. 15, S. 2862 – 2869
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The spindle-assembly checkpoint in space and timeIn: Nature reviews : molecular cell biology , Jg. 8 2007, Nr. 5, S. 379 – 393
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The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephalyIn: Structure , Jg. 15 2007, Nr. 11, S. 1467 – 1481
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Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiaeIn: The Journal of Cell Biology (JCB) , Jg. 174 2006, Nr. 1, S. 39 – 51
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Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitinIn: Cell , Jg. 124 2006, Nr. 6, S. 1183 – 1195
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Determinants of conformational dimerization of Mad2 and its inhibition by p31cometIn: The EMBO Journal , Jg. 25 2006, Nr. 6, S. 1273 – 1284
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In vitro FRAP identifies the minimal requirements for Mad2 kinetochore dynamicsIn: Current biology , Jg. 16 2006, Nr. 8, S. 755 – 766
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Kinetochore microtubule dynamics and attachment stability are regulated by Hec1In: Cell , Jg. 127 2006, Nr. 5, S. 969 – 982
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Architecture of the human Ndc80-Hec1 complex, a critical constituent of the outer kinetochoreIn: The Journal of Biological Chemistry (JBC) , Jg. 280 2005, Nr. 32, S. 29088 – 29095
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Explaining the oligomerization properties of the spindle assembly checkpoint protein Mad2In: Philosophical transactions of the Royal Society : series B, biological sciences , Jg. 360 2005, Nr. 1455, S. 637 – 648
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Mechanism of Aurora B activation by INCENP and inhibition by HesperadinIn: Molecular cell , Jg. 18 2005, Nr. 3, S. 379 – 391
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The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpointIn: Current biology , Jg. 15 2005, Nr. 3, S. 214 – 225
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Crystal structure of the tetrameric Mad1-Mad2 core complex : implications of 'safety belt' binding mechanism for the spindle checkpointIn: The EMBO Journal , Jg. 21 2002, Nr. 10, S. 2496 – 2506
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The spindle checkpoint : structural insights into dynamic signallingIn: Nature reviews : molecular cell biology , Jg. 3 2002, Nr. 10, S. 731 – 741
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Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochoresIn: The EMBO Journal , Jg. 20 2001, Nr. 23, S. 6648 – 6659
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Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for spindle checkpointIn: The EMBO Journal , Jg. 20 2001, Nr. 22, S. 6371 – 6382
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Structure and regulation of the CDK5-p25nck5a complexIn: Molecular cell , Jg. 8 2001, Nr. 3, S. 657 – 669
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A mutation in the pleckstrin homology (PH) domain of the FGD1 gene in an Italian family with faciogenital dysplasia (Aarskog-Scott syndrome)In: FEBS Letters , Jg. 478 2000, Nr. 3, S. 216 – 220
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SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55In: The EMBO Journal , Jg. 19 2000, Nr. 12, S. 2889 – 2899
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Functional organization of clathrin in coats : combining electron cryomicroscopy and x-ray crystallographyIn: Molecular cell , Jg. 3 1999, Nr. 6, S. 761 – 770
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Atomic structure of clathrin : a β propeller terminal domain joins an α zigzag linkerIn: Cell , Jg. 95 1998, Nr. 4, S. 563 – 573
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Crystal structure of the breakpoint cluster region homology domain from phosphoinositide 3-kinase p85 alpha subunitIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Jg. 93 1996, Nr. 25, S. 14373 – 14378
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Structure and function of the SH3 domainIn: Progress in biophysics and molecular biology , Jg. 61 1994, Nr. 3, S. 283 – 297
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Crystal structure of the SH3 domain in human Fyn : comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrinIn: The EMBO Journal , Jg. 12 1993, Nr. 7, S. 2617 – 2624
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Crystallization and preliminary x-ray analysis of the periplasmic fragment of CyoA-a subunit of the Escherichia coli cytochrome o complexIn: Journal of Molecular Biology (JMB) , Jg. 229 1993, Nr. 3, S. 794 – 796
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The PH domain : a common piece in the structural pathcwork of signalling proteinsIn: Trends in biochemical sciences , Jg. 18 1993, Nr. 9, S. 343 – 348
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Crystal structure of a Src-homology 3 (SH3) domainIn: Nature , Jg. 359 1992, Nr. 6398, S. 851 – 855
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Cell cycle, differentiation and disease : editorial overviewIn: Current Opinion in Cell Biology , Jg. 25 2013, Nr. 6, S. 673 – 675
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Ipl1-controlled attachment maturation regulates Mps1 association with its kinetochore receptor2023DOI (Open Access)