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Ivelina Spassova

Funktionen

  • Mitarbeiter/-in AG Prof. Dr. med. J. Becker, Klinik für Dermatologie

Aktuelle Veranstaltungen

Keine aktuellen Veranstaltungen.

Vergangene Veranstaltungen (max. 10)

Keine vergangenen Veranstaltungen.

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Srinivas, Nalini; Spassova, Ivelina; Lei, Kuan Cheok; Gao, Jiwei; Pino, María José; Giglio, Giovanni; Kitanovski, Simo; Dalkoohi, Mazdak; Livingstone, Elisabeth; Leiter, Ulrike; Mohr, Peter; Gambichler, Thilo; Stoffels, Ingo; Ugurel, Selma; Cheung, Phyllis Fung-Yi; Engblom, Camilla; Lui, Weng-Onn; Becker, Jürgen Christian
    Tertiary lymphoid structures in Merkel cell carcinoma facilitate naïve and central memory T-cell infiltration linked to immunotherapy response
    In: Journal for ImmunoTherapy of Cancer, Jg. 13, 2025, Nr. 9, S. e012224
    DOI (Open Access)
  • Lei, Kuan Cheok; Srinivas, Nalini; Chandra, Mitalee; Kervarrec, Thibault; Coyaud, Etienne; Spassova, Ivelina; Peiffer, Lukas; Houben, Roland; Shuda, Masahiro; Hoffmann, Daniel; Schrama, David; Becker, Jürgen
    Merkel cell polyomavirus pan-T antigen knockdown reduces cancer cell stemness and promotes neural differentiation independent of RB1
    In: Journal of Medical Virology, Jg. 96, 2024, Nr. 7, e29789
    DOI (Open Access)
  • DeTemple, Viola K.; Ritter, Cathrin; Srinivas, Nalini; Spassova, Ivelina; Gambichler, Thilo; Hüning, Svea; Gräger, Nikolai; Gutzmer, Ralf; Bröcker, Eva-Bettina; Ugurel, Selma; Schrama, David; Becker, Jürgen
    Short- and long-term immunosuppressive effects of melanoma influence the prognostic value of the sentinel lymph node status
    In: European Journal of Cancer (EJC), Jg. 212, 2024, 115054
    DOI (Open Access)
  • Srinivas, Nalini; Peiffer, Lukas; Horny, Kai; Lei, Kuan Cheok; Buus, Terkild B.; Kubat, Linda; Luo, Meng; Yin, Menghong; Spassova, Ivelina; Sucker, Antje; Farahpour, Farnoush; Kehrmann, Jan; Ugurel, Selma; Livingstone, Elisabeth; Gambichler, Thilo; Ødum, Niels; Becker, Jürgen C.
    Single-cell RNA and T-cell receptor sequencing unveil mycosis fungoides heterogeneity and a possible gene signature
    In: Frontiers in Oncology, Jg. 14, 2024, 1408614
    DOI (Open Access)
  • Schaper-Gerhardt, Katrin; Gutzmer, Ralf; Angela, Yenny; Zimmer, Lisa; Livingstone, Elisabeth; Schadendorf, Dirk; Hassel, Jessica C.; Weishaupt, Carsten; Remes, Bernhard; Kubat, Linda; Spassova, Ivelina; Becker, Jürgen
    The RANKL inhibitor denosumab in combination with dual checkpoint inhibition is associated with increased CXCL-13 serum concentrations
    In: European Journal of Cancer (EJC), Jg. 202, 2024, 113984
    DOI (Open Access)
  • Horny, Kai; Sproll, Christoph; Peiffer, Lukas; Furtmann, Frauke; Gerhardt, Patricia; Gravemeyer, Jan; Stoecklein, Nikolas H.; Spassova, Ivelina; Becker, Jürgen
    Mesenchymal–epithelial transition in lymph node metastases of oral squamous cell carcinoma is accompanied by ZEB1 expression
    In: Journal of Translational Medicine, Jg. 21, 2023, Nr. 1, 267
    DOI (Open Access)
  • Peiffer, Lukas; Gambichler, Thilo; Buus, Terkild B.; Horny, Kai; Gravemeyer, Jan; Furtmann, Frauke; Spassova, Ivelina; Kubat, Linda; Susok, Laura; Stranzenbach, René; Srinivas, Nalini; Ødum, Niels; Becker, Jürgen
    Phenotypic plasticity of malignant T cells in blood and skin of a Sézary syndrome patient revealed by single cell transcriptomics
    In: Frontiers in Oncology, Jg. 13, 2023, 1090592
    DOI (Open Access)
  • Spassova, Ivelina; Ugurel, Selma; Kubat, Linda; Zimmer, Lisa; Terheyden, Patrick; Mohr, Annalena; Björn Andtback, Hannah; Villabona, Lisa; Leiter, Ulrike; Eigentler, Thomas; Loquai, Carmen; Hassel, Jessica C.; Gambichler, Thilo; Haferkamp, Sebastian; Mohr, Peter; Pfoehler, Claudia; Heinzerling, Lucie; Gutzmer, Ralf; Utikal, Jochen S.; Horny, Kai; Schildhaus, Hans-Ulrich; Habermann, Daniel; Hoffmann, Daniel; Schadendorf, Dirk; Becker, Jürgen
    Clinical and molecular characteristics associated with response to therapeutic PD-1/PD-L1 inhibition in advanced Merkel cell carcinoma
    In: Journal for ImmunoTherapy of Cancer, Jg. 10, 2022, Nr. 1, e003198
    DOI, Online Volltext (Open Access)
  • Gravemeyer, Jan; Spassova, Ivelina; Verhaegen, Monique E.; Dlugosz, Andrzej A.; Hoffmann, Daniel; Lange, Anja; Becker, Jürgen
    DNA-methylation patterns imply a common cellular origin of virus- and UV-associated Merkel cell carcinoma
    In: Oncogene, Jg. 41, 2022, Nr. 1, S. 37 – 45
    DOI (Open Access)
  • Pfeiffer, Lukas; Farahpour, Farnoush; Sriram, Ashwin; Spassova, Ivelina; Hoffmann, Daniel; Kubat, Linda; Stoitzner, Patrizia; Gambichler, Thilo; Sucker, Antje; Ugurel, Selma; Schadendorf, Dirk; Becker, Jürgen C.
    BRAF and MEK inhibition in melanoma patients enables reprogramming of tumor infiltrating lymphocytes
    In: Cancer Immunology, Immunotherapy, Jg. 70, 2021, Nr. 6, S. 1635 – 1647
    DOI (Open Access)
  • Gravemeyer, Jan; Lange, Anja; Ritter, Cathrin; Spassova, Ivelina; Song, Lina; Picard, Daniel; Remke, Marc; Horny, Kai; Sriram, Ashwin; Gambichler, Thilo; Schadendorf, Dirk; Hoffmann, Daniel; Becker, Jürgen
    Classical and Variant Merkel Cell Carcinoma Cell Lines Display Different Degrees of Neuroendocrine Differentiation and Epithelial-Mesenchymal Transition
    In: Journal of Investigative Dermatology, Jg. 141, 2021, Nr. 7, S. 1675 – 1686.e4
    DOI (Open Access)
  • Fan, Kaiji; Spassova, Ivelina; Gravemeyer, Jan; Ritter, Cathrin; Horny, Kai; Lange, Anja; Gambichler, Thilo; Ødum, Niels; Schrama, David; Schadendorf, Dirk; Ugurel, Selma; Becker, Jürgen
    Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53
    In: Oncogene, Jg. 40, 2021, Nr. 5, S. 980 – 996
    DOI (Open Access)
  • Song, Lina; Bretz, Anne Catherine; Gravemeyer, Jan; Spassova, Ivelina; Muminova, Shakhlo; Gambichler, Thilo; Sriram, Ashwin; Ferrone, Soldano; Becker, Jürgen
    The HDAC Inhibitor Domatinostat Promotes Cell-Cycle Arrest, Induces Apoptosis, and Increases Immunogenicity of Merkel Cell Carcinoma Cells
    In: Journal of Investigative Dermatology, Jg. 141, 2021, Nr. 4, S. 903 – 912.e4
    DOI (Open Access)
  • Hillen, Lisa M.; Geybels, Milan S.; Spassova, Ivelina; Becker, Jürgen; Gambichler, Thilo; Garmyn, Marjan; Hausen, Axel zur; Oord, Joost van den; Winnepenninckx, Véronique
    A digital mRNA expression signature to classify challenging Spitzoid melanocytic neoplasms
    In: FEBS Open Bio, Jg. 10, 2020, Nr. 7, S. 1326 – 1341
    DOI (Open Access)
  • Spassova, Ivelina; Ugurel, Selma; Terheyden, Patrick; Sucker, Antje; Hassel, Jessica C.; Ritter, Cathrin; Kubat, Linda; Habermann, Daniel; Farahpour, Farnoush; Saeedghalati, Mohammadkarim; Peiffer, Lukas; Kumar, Rajiv; Schrama, David; Hoffmann, Daniel; Schadendorf, Dirk; Becker, Jürgen C.
    Predominance of Central Memory T Cells with High T-Cell Receptor Repertoire Diversity is Associated with Response to PD-1/PD-L1 Inhibition in Merkel Cell Carcinoma
    In: Clinical Cancer Research, Jg. 26, 2020, Nr. 9, S. 2257 – 2267
    DOI (Open Access)
  • Farah, Maya; Reuben, Alexandre; Spassova, Ivelina; Yang, Richard K.; Kubat, Linda; Nagarajan, Priyadharsini; Ning, Jing; Li, Wen; Aung, Phyu P.; Curry, Jonathan L.; Torres-Cabala, Carlos A.; Hudgens, Courtney W.; Ugurel, Selma; Schadendorf, Dirk; Gumbs, Curtis; Little, Latasha D.; Futreal, Andrew; Wistuba, Ignacio I.; Prieto, Victor G.; Wang, Linghua; Wong, Michael K.; Wargo, Jennifer A.; Becker, Jürgen; Tetzlaff, Michael T.
    T-Cell Repertoire in Combination with T-Cell Density Predicts Clinical Outcomes in Patients with Merkel Cell Carcinoma
    In: Journal of Investigative Dermatology, Jg. 140, 2020, Nr. 11, S. 2146 – 2156.e4
    DOI (Open Access)
  • Chen, I-Peng; Bender, Marc; Spassova, Ivelina; Henning, Stefan; Kubat, Linda; Fan, Kaiji; Degenhardt, Sarah; Mhamdi-Ghodbani, Mouna; Sriram, Ashwin; Volkmer, Beate; Boukamp, Petra; Becker, Jürgen; Greinert, Rüdiger
    UV-type specific alteration of miRNA expression and its association with tumor progression and metastasis in SCC cell lines
    In: Journal of Cancer Research and Clinical Oncology, Jg. 146, 2020, Nr. 12, S. 3215 – 3231
    DOI
  • Ugurel, Selma; Spassova, Ivelina; Wohlfarth, Jonas; Drusio, Christina; Cherouny, Angela; Melior, Anita; Sucker, Antje; Zimmer, Lisa; Ritter, Cathrin; Schadendorf, Dirk; Becker, Jürgen
    MHC class-I downregulation in PD-1/PD-L1 inhibitor refractory Merkel cell carcinoma and its potential reversal by histone deacetylase inhibition : a case series
    In: Cancer Immunology, Immunotherapy, Jg. 68, 2019, Nr. 6, S. 983 – 990
    DOI, Online Volltext (Open Access)
  • Bhat, Vishwanath Kumble; Bernhart, Eva; Plastira, Ioanna; Fan, Kaiji; Ghaffari-Tabrizi-Wizsy, Nassim; Wadsack, Christian; Rechberger, Gerald; Eichmann, Thomas; Asslaber, Martin; Spassova, Ivelina; Verhaegen, Monique E.; Malle, Ernst; Becker, Jürgen; Sattler, Wolfgang
    Pharmacological inhibition of serine palmitoyl transferase and sphingosine kinase-1/-2 inhibits Merkel Cell Carcinoma cell proliferation
    In: Journal of Investigative Dermatology, Jg. 139, 2019, Nr. 4, S. 807 – 817
    DOI (Open Access)
  • Hillen, Lisa M.; Geybels, Milan S.; Rennspiess, Dorit; Spassova, Ivelina; Ritter, Cathrin; Becker, Jürgen; Garmyn, Marjan; Zur Hausen, Axel; Van Den Oord, Joost; Winnepenninckx, Véronique
    Molecular profiling of Spitz nevi identified by digital RNA counting
    In: Melanoma Research, Jg. 28, 2018, Nr. 6, S. 510 – 520
    DOI (Open Access)

    • Abstracts

  • Peiffer, Likas; Lindahl, Lise M.; Kubat, Linda; Spassova, Ivelina; Gravemeyer, Jan; Litman, Thomas; Willserslev-Olsen, A.; Woetmann, A.; Iversen, Line; Odum, Niels; Becker, Jürgen
    Das reaktive Infiltrat beim kutanen T-Zell-Lymphom ist höchst unbeständig und zeigt keine der typischen Merkmale von Antigenspezifität
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG). Hoboken: Wiley-Blackwell - STM, Jg. 18, 2020, Nr. Suppl. 2: Special Issue: Abstractband anlässlich des 30. Deutschen Hautkrebskongresses (ADO‐Jahrestagung) 09.–12. September 2020, S. FV10
    DOI (Open Access)
  • Spassova, Ivelina; Ugurel, Selma; Zimmer, Lisa; Schadendorf, Dirk; Terheyden, Patrick; Andtback, H. B.; Villabona, Luis; Leiter-Stoeppke, Ulrike; Eigentler, Thomas K.; Loquai, Carmen; Hassel, Jessica C.; Gambichler, Thilo; Haferkamp, Sebastian; Mohr, Peter; Pfoehler, Claudia; Heinzerling, L.; Horny, Kai; Habermann, Dirk; Hoffmann, D.; Becker, Jürgen
    Immun‐Checkpoint‐Blockade beim Merkelzellkarzinom : Klinische und molekulare Biomarker‐Analyse
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG). Hoboken: Wiley-Blackwell - STM, Jg. 18, 2020, Nr. Suppl. 2: Special Issue: Abstractband anlässlich des 30. Deutschen Hautkrebskongresses (ADO‐Jahrestagung) 09.–12. September 2020, S. FV22
    DOI (Open Access)
  • Spassova, Ivelina; Ugurel, Selma; Kubat, L.; Terheyden, P.; Hassel, J.; Schadendorf, Dirk; Becker, Jürgen
    Biomarkers of response to PD‐1 inhibition in Merkel cell carcinoma
    28. Deutschen Hautkrebskongresses (ADO‐Jahrestagung); 13.–15. September 2018; Stuttgart,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG). Hoboken: Wiley-Blackwell - STM, Jg. 16, 2018, Nr. S6, S. 5
    DOI (Open Access)
  • Peiffer, L.; Lindahl, L. M.; Kubat, L.; Spassova, Ivelina; Gravemeyer, J.; Willerslev‐Olsen, A.; Woetmann, A.; Iversen, L.; Ritter, Cathrin; Ødum, N.; Becker, Jürgen
    Eine Dysbakterie auf der Haut von Mycosis fungoides Patienten beeinflusst die Progression der Krankheit durch Polarisierung des reaktiven Infiltrates
    Konferenz 28. Deutschen Hautkrebskongresses (ADO‐Jahrestagung); 13.–15. September 2018; Stuttgart,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG). Hoboken: Wiley-Blackwell - STM, Jg. 16, 2018, Nr. S6, S. 4 – 5
    DOI (Open Access)
  • Gravemeyer, J.; Lange, A.; Wülbeck, Corinna; Melior, Anita; Spassova, Ivelina; Gambichler, T.; Ritter, Cathrin; Becker, Jürgen
    Epigenetisches Profiling unterscheidet variante MCC‐Zelllinien von klassischen MCC‐ als auch SCC‐Zellinien
    28. Deutschen Hautkrebskongresses (ADO‐Jahrestagung); 13.–15. September 2018; Stuttgart,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG). Hoboken: Wiley-Blackwell - STM, Jg. 16, 2018, Nr. S6, S. 23 – 24
    DOI (Open Access)

    • Dissertation

  • Spassova, Ivelina
    Prognostic and predictive biomarkers in Merkel cell carcinoma
    Duisburg, Essen, 2020
    DOI, Online Volltext (Open Access)