Project B05 investigates how metabolic rewiring of tumor-associated macrophages (TAM) drives early resistance to immune checkpoint inhibition in melanoma. Using spatial multi-omics, multiplex imaging, proteomics, and patient-derived melanoma models, the project aims to identify metabolic TAM states and cellular neighborhoods that shape anti-tumor immunity during the earliest phases of therapy response. By integrating clinical patient samples with functional experimental models, B05 seeks to uncover novel biomarkers and therapeutic targets to improve long-term immunotherapy outcomes in melanoma.

Project Leaders

Engel, Daniel Robert, Prof. Dr. rer. nat.

• http://www.immunodynamics.de/

Roesch, Alexander, Prof. Dr. med.

• https://www.uni-due.de/zmb/members/alexander-roesch.php