Project C02 is the central biobank hub of the CRC and aims to develop a platform for automated molecular hypothesis validation and generation. The project will connect patient-derived tumor and blood samples at baseline and early on-therapy to mechanistic questions across datasets. Through integrated clinical annotation and automated data analysis workflows, C02 provides a clinically grounded and computationally standardized basis for uncovering and validating immediate therapy-adaptation, supporting all key goals of DYNAMO and ultimately identifying complex biomarkers.

Project Leaders

Köster, Johannes, Prof. Dr. rer. nat.

• https://koesterlab.github.io/

Schadendorf, Dirk, Prof. Dr. med.

• https://www.uni-due.de/zmb/members/dirk-schadendorf.php