HIV Reservoir and Cure Research
ART transformed HIV into a manageable condition but spares latently infected cells that form long-lived reservoirs and fuel rebound. We use systems virology, CRISPR, and patient-derived models to define and target these reservoirs.
Inflammatory Circuits and Pyroptosis
Abortive HIV in tissue CD4⁺ T cells triggers inflammasome–caspase-1 pyroptosis, amplifying inflammation. We map extrinsic and host drivers in tonsil and cell-line models to guide targeted anti-inflammatory strategies.
Antivirals Discovery
From pan-antiviral candidates to delivery, we probe mechanisms, resistance, and host-dependent therapy failure with collaborative screens.
Immunometabolic Virology
Viruses reprogram cellular metabolism, while host metabolic state and microenvironment shape infection outcome. We use single-cell profiling, Seahorse/MS and CRISPR to map metabolic dependencies and identify therapeutic targets.
Cytoskeleton and Orthohantavirus Dynamics
Orthohantaviruses are zoonotic, tri-segmented negative-sense RNA viruses that can cause severe human disease. We map host–virus interfaces—including glycoprotein entry, cytoskeletal remodeling and P-body interactions—using interactomics, CRISPR and quantitative microscopy to identify host-directed antiviral targets.